Highlights
Until the 30 October 2026, the WHO Quality Assurance Mechanism for Modified Mosquito Production (QAM), a proposed regulatory mechanism designed to address the growing needs for quality assessments and manufacturing site audits of Modified Mosquito Products which may be intended for use in public health programmes, is open for public consultation. The purpose of the QAM is to establish an independent assessment by WHO of MMPs and their manufacturing facilities to support Member States and other UN bodies.
Submit comments by email to pqvectorcontrol@who.int, using the subject line “Comments on Proposed QAM Pilot documents – [Insert organization name].”
List of Compliant Vector Control Active Ingredients
Beginning in March 2026, sent Letters of Agreement (LoA) to 48 manufacturers of VCAIs to formalize the procedures for WHO Assessment of Vector Control Active Ingredients. The Overview of the WHO Assessment of Vector Control Active Ingredient Products (“VCAI Procedures”) which apply to the active ingredient source materials, intended for use in the formulation of public health pesticides, submitted by manufacturers to demonstrate compliance with WHO -recommended quality standards and therefore acceptable for use in the formulation of Vector Control Products (VCP) which have been or are proposed to be evaluated by WHO for the purpose of prequalification. To ensure the inclusion of VCAIs in the list of VCAIs confirmed to comply with WHO specifications, WHO/PQT requested the agreement to be signed and returned to pqvectorcontrol@who.int.
Only those VCAIs for which the LoA has been signed and returned will be considered as acceptable sources for use in the formulation of prequalified VCPs.
The List of Compliant Vector Control Active Ingredients has been published.
As of October 2026, there are 87 VCAIs listed across 37 different active ingredients.
ePQS Portal
With the successful first year of the ePQS Portal, we continue to encourage all VCP applicants to register as portal users. Information about the ePQS portal and the ePQS User Registration Form can be found here:
As of 30 May 2026, all applications for new products and changes must be submitted through the ePQS portal.
Prequalification pipeline
All products that have been accepted for PQT/VCP assessment can be found on the pipeline page.
PQT/VC Ref Number | Product name | Product type | Applicant | AI/Synergist |
P-13707 | Natular DT Mini | Larvicide | Clarke International | Under Assessment |
P-14014 | EON Net 2 | ITN | Sambhv Lifescience Pvt. Ltd | Under Assessment |
P-13655 | EON Net | ITN | Sambhv Lifescience Pvt. Ltd | Under Assessment |
P-13814 | Yahe Dual | ITN | Fujian Yamei Industry & Trade Co. Ltd | Under Assessment |
P-14258 | EvaDualNet | ITN | STS Agricon Private Limited | Under Assessment |
P-14464 | DuraDualNet | ITN | Shobikaa Impex Private Limited | Under Assessment |
P-14614 | Avatar Dual | ITN | Sambhv Lifescience Pvt. Ltd | Under Assessment |
P-14611 | Terminator Dual | ITN | Brijwasi Plastic Pvt. Ltd. | Under Assessment |
P-14600 | Barcelo | Larvicide | Envu (Environmental Science U.S. LLC) | Under Assessment |
Target timelines for assessment and listing decision(s) are 365 WHO days from the date of acceptance for assessment. WHO days are defined as those days in which the product dossier is with WHO for assessment, i.e., does not include manufacturer time to respond to Requests for Information.
Recently published documents
Manuals/guidance documents
The following documents have been developed and are being published for the purpose of a 60-day public comment period prior to the launch of the proposed pilot – Quality Assurance Mechanism for Modified Mosquito Production:
Procedures for the Pilot of the WHO programme for Quality Assurance of Modified Mosquito Production
More information at: Pilot – Quality Assurance Mechanism for Modified Mosquito Production | WHO - Prequalification of Medical Products (IVDs, Medicines, Vaccines and Immunization Devices, Vector Control)
Reports
The report on the Technical Consultation for Gender Mainstreaming in Vector Control Product Regulation has been published on the VCP prequalification website
https://extranet.who.int/prequal/vector-control-products/technical-consultations
Advice to Manufacturer Series (AMS) Documents
Supporting templates for the Preparation of supporting statistical files for submission in product dossiers have been published.
Checklists for chemistry raw data submission (excel spreadsheets) (September 2026)
Template ITN chemical analysis BQC (September 2026)
Template ITN chemical analysis regeneration study (September 2026)
Template ITN chemical analysis wash resistance study (September 2026)
Template ITN chemical analysis semi field study (September 2026)
Specifications and WHOPARs
The specification for Permethrin (40 60 cis trans isomer ratio) has been updated with the evaluation report 331/2026 related to the extension of the existing WHO Permethrin (40 60 cis trans isomer ratio) TC specification to encompass the technical material produced by Bharat Rasayan Limited.
The specification for Pyriproxyfen has been updated with the evaluation report 715/2026 related to the extension of the existing WHO Pyriproxyfen TC specification to encompass the technical material produced by Hemani Industries Ltd.
The specification for S-Methoprene has been updated for correction of detected typos:
- The name to be expressed just as common name S-methoprene
- The 940 g/kg was referring to the S-methoprene content and not the total. Hence, the 97% clause (clause 2.3) has been removed.
- The S-methoprene identity (clause 2.1) is defined by the combined use of the method published in CIPAC Handbook M and of the stereospecific method for S-methoprene, available as pre-published method at CIPAC website.
- The S-methoprene content (clause 2.2) is defined by the two methods in brackets (414/TC/M/3, CIPAC Handbook M, p. 116, 2006 and 1026/TC/(M)/3, CIPAC/5359) with a footnote regarding the sequence of the methods: the determination of S-methoprene content relies on the combined use of the chemical purity method published in CIPAC Handbook M and of the stereospecific method for S-methoprene available as pre-published method at CIPAC website (determine first the total methoprene, and then the chiral method for the quantification of the S stereoisomer , given that the trial for the first method only determined the ratios in the total and not the quantification of S-methoprene, which was determined in the second method).
- Part 2 - FAO/WHO EVALUATION REPORT 1026/2025 changes to be consistent with the changes in Part 1 - specification.