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WTS Database
The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title | Pub Year Sort ascending | Author | SearchLink |
|---|---|---|---|
| Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis | 2013 | * Biological Sciences Department, Faculty of Pharmaceutical Sciences. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Medical mycology
Periodical, Abbrev.
Med.Mycol.
Pub Date Free Form
Oct
Volume
51
Issue
7
Start Page
673
Other Pages
682
Notes
JID: 9815835; 0 (Antifungal Agents); 0 (Flavones); 0 (Ointments); 0 (Plant Extracts); 2013/06/13 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1460-2709; 1369-3786
Accession Number
PMID: 23758104
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.3109/13693786.2013.795294 [doi]
Output Language
Unknown(0)
PMID
23758104
Abstract
The purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
de Freitas Araujo,M.G., Pacifico,M., Vilegas,W., Dos Santos,L.C., Icely,P.A., Miro,M.S., Scarpa,M.V., Bauab,T.M., Sotomayor,C.E.
Original/Translated Title
URL
Date of Electronic
20130613
PMCID
Editors
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| Cigarette smoking and quit attempts among injection drug users in Tijuana, Mexico | 2013 | Joint Doctoral Program in Public Health (Global Health), San Diego State University/University of California San Diego, San Diego, CA; | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Dec
Volume
15
Issue
12
Start Page
2060
Other Pages
2068
Notes
LR: 20150423; GR: 1R36DA033152/DA/NIDA NIH HHS/United States; GR: D43 TW008633/TW/FIC NIH HHS/United States; GR: R36 DA033152/DA/NIDA NIH HHS/United States; GR: R37 DA019829/DA/NIDA NIH HHS/United States; GR: R37DA019829/DA/NIDA NIH HHS/United States; GR:
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 23873979
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1093/ntr/ntt099 [doi]
Output Language
Unknown(0)
PMID
23873979
Abstract
INTRODUCTION: Injection drug use and cigarette smoking are major global health concerns. Limited data exist regarding cigarette smoking behavior and quit attempts among injection drug users (IDUs) in low- and middle-income countries to inform the development of cigarette smoking interventions. We conducted a cross-sectional study to describe cigarette smoking behavior and quit attempts among IDUs in Tijuana, Mexico. METHODS: IDUs were recruited through community outreach and administered in-person interviews. Multivariable Poisson regression models were constructed to determine prevalence ratios (PRs) for quit attempts. RESULTS: Of the 670 participants interviewed, 601 (89.7%) were current smokers. Of these, median number of cigarettes smoked daily was 10; 190 (31.6%) contemplated quitting smoking in the next 6 months; 132 (22.0%) had previously quit for >/=1 year; and 124 (20.6%) had made a recent quit attempt (lasting >/=1 day during the previous 6 months). In multivariable analysis, recent quit attempts were positively associated with average monthly income (>/=3,500 pesos [US$280] vs.
Descriptors
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Database
Publisher
Data Source
Authors
Shin,S.S., Moreno,P.G., Rao,S., Garfein,R.S., Novotny,T.E., Strathdee,S.A.
Original/Translated Title
URL
Date of Electronic
20130719
PMCID
PMC3819980
Editors
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| The independent effects of second hand smoke exposure and maternal body mass index on the anthropometric measurements of the newborn | 2013 | Sheikh Bahamdan Research Chair of Evidence-based Healthcare and Knowledge translation, College of Medicine, King Saud University, P,O Box 102799, Riyadh 11685, Kingdom of Saudi Arabia. umlena@yahoo.com. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC public health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
9-Nov
Volume
13
Issue
Start Page
1058
Other Pages
2458-13-1058
Notes
LR: 20150422; JID: 100968562; 0 (Tobacco Smoke Pollution); OID: NLM: PMC4226006; 2013/07/12 [received]; 2013/11/07 [accepted]; 2013/11/09 [aheadofprint]; epublish
Place of Publication
England
ISSN/ISBN
1471-2458; 1471-2458
Accession Number
PMID: 24209496
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1186/1471-2458-13-1058 [doi]
Output Language
Unknown(0)
PMID
24209496
Abstract
BACKGROUND: Exposure to tobacco smoke during pregnancy, whether as active smoking or by exposure to secondhand smoke (SHS), is associated with adverse pregnancy outcomes including low birth weight (LBW) and small for gestational age infants due to the effect of tobacco on the anthropometric measurements of the newborn. This effect might be masked by maternal obesity as it increases fetal weight. The objectives of this study were to estimate the independent effects of maternal exposure to SHS and maternal body mass index (BMI) on the anthropometric measurements and on the prevalence of macrosomia and LBW among term infants. METHODS: Data were collected from women in the postnatal ward following delivery. Participants were stratified into six groups based on the BMI (underweight /=30 kg/m(2)) and the SHS exposure status (exposed and non- exposed), to examine the independent effects of BMI and SHS on infants' anthropometry. Multiple regression analysis was used to explore the independent associations between the six groups and the risk of delivering a macrosomic or LBW infant. RESULTS: Infants of women exposed to SHS had significantly reduced anthropometric measurements compared to infants of unexposed women. The odds of delivering a macrosomic baby increased to 9-fold for women with BMI of >/=30 kg/m(2) compared to non-obese women; odds ratio (OR) 9.18, 95% Confidence Interval (CI) (1.01, 9.37); p = 0.04, this risk was attenuated to 1.5-fold in women exposed to SHS, OR 1.53, 95% CI (1.19, 12.1); p
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Wahabi,H.A., Mandil,A.A., Alzeidan,R.A., Bahnassy,A.A., Fayed,A.A.
Original/Translated Title
URL
Date of Electronic
20131109
PMCID
PMC4226006
Editors
|
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| Clinical features of patients with infections caused by Candida guilliermondii and Candida fermentati and antifungal susceptibility of the isolates at a medical centre in Taiwan, 2001-10 | 2013 | Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Journal of antimicrobial chemotherapy
Periodical, Abbrev.
J.Antimicrob.Chemother.
Pub Date Free Form
Nov
Volume
68
Issue
11
Start Page
2632
Other Pages
2635
Notes
JID: 7513617; 0 (Antifungal Agents); OTO: NOTNLM; 2013/06/13 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1460-2091; 0305-7453
Accession Number
PMID: 23766486
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/jac/dkt214 [doi]
Output Language
Unknown(0)
PMID
23766486
Abstract
OBJECTIVES: This study was intended to analyse the clinical characteristics and outcomes of patients with infections due to Candida guilliermondii complex and evaluate in vitro susceptibilities of the isolates. METHODS: We searched the Mycology Database of the National Taiwan University Hospital and identified patients with infections due to C. guilliermondii complex from 2001 to 2010. Isolates were identified to species level by two yeast identification systems and restriction fragment length polymorphism of the riboflavin synthetase gene. MICs of nine antifungal agents were determined using the Sensititre YeastOne system (Trek Diagnostic Systems) and were interpreted by breakpoints (BPs) for three echinocandins and epidemiological cut-off values (ECVs) for the other agents. RESULTS: Fifty-two patients with infections due to C. guilliermondii complex were evaluated. The majority (90%, n = 47) of the isolates were C. guilliermondii, followed by Candida fermentati (10%, n = 5). Among them, 42 (81%) were isolated from blood cultures. Among the 52 patients, 27 (52%) had underlying malignancy and 15 (29%) had undergone abdominal surgery. The 30 day mortality rates among patients with C. guilliermondii and C. fermentati infections were 45% and 60%, respectively. Among C. guilliermondii isolates, 98%, 100% and 98% were susceptible to caspofungin, micafungin and anidulafungin, respectively, by BPs. Nearly all (96%-100%) C. guilliermondii isolates belonged to wild-type for the other agents by ECVs. All five C. fermentati were susceptible to three echinocandins and belonged to wild-type for the other agents. CONCLUSIONS: The currently used antifungal agents exhibited good in vitro activities against C. guilliermondii complex isolates.
Descriptors
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Book Title
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Publisher
Data Source
Authors
Chen,C.Y., Huang,S.Y., Tang,J.L., Tsay,W., Yao,M., Ko,B.S., Chou,W.C., Tien,H.F., Hsueh,P.R.
Original/Translated Title
URL
Date of Electronic
20130613
PMCID
Editors
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| Parental smoking patterns and their association with wheezing in children | 2013 | Universidade de Sao Paulo, Hospital das Clinicas, Instituto da Crianca, Faculdade de Medicina, Sao Paulo, SP, Brazil. schvartsman@einstein.br | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Clinics (Sao Paulo, Brazil)
Periodical, Abbrev.
Clinics (Sao.Paulo)
Pub Date Free Form
Jul
Volume
68
Issue
7
Start Page
934
Other Pages
939
Notes
LR: 20151119; JID: 101244734; 0 (Tobacco Smoke Pollution); K5161X06LL (Cotinine); OID: NLM: PMC3714778; 2013/02/17 [received]; 2013/03/10 [accepted]; ppublish
Place of Publication
Brazil
ISSN/ISBN
1980-5322; 1807-5932
Accession Number
PMID: 23917656
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.6061/clinics/2013(07)08 [doi]
Output Language
Unknown(0)
PMID
23917656
Abstract
OBJECTIVE: To investigate parental smoking patterns and their association with wheezing in children. METHODS: We performed a case-control study that included 105 children between 6 and 23 months of age who were divided into two groups: cases (children with 3 previous episodes of wheezing) and controls (healthy children without wheezing). The children's exposure to cigarette smoking was estimated using a questionnaire completed by the mothers and by the children's urinary cotinine levels. RESULTS: Based on both the questionnaire results and cotinine levels, exposure to cigarette smoking was higher in the households of cases in which the incidence of maternal smoking was significantly higher than that of paternal smoking. Children in this group were more affected by maternal smoking and by the total number of cigarettes smoked inside the house. Additionally, the questionnaire results indicated that the risk of wheezing was dose dependent. The presence of allergic components, such as atopic dermatitis and siblings with allergic rhinitis and asthma, greatly increased the odds ratio when wheezing was associated with cotinine levels. CONCLUSION: Children exposed to tobacco smoke have an increased risk of developing wheezing syndrome. This risk increases in association with the number of cigarettes smoked inside the house and the presence of other allergic components in the family.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Schvartsman,C., Farhat,S.C., Schvartsman,S., Saldiva,P.H.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC3714778
Editors
|
|||
| Hookah, cigarette, and marijuana use: a prospective study of smoking behaviors among first-year college women | 2013 | Department of Psychology, Syracuse University, Syracuse, NY, USA. rlfielde@syr.edu | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Addictive Behaviors
Periodical, Abbrev.
Addict.Behav.
Pub Date Free Form
Nov
Volume
38
Issue
11
Start Page
2729
Other Pages
2735
Notes
LR: 20150423; CI: (c) 2013; GR: R21 AA018257/AA/NIAAA NIH HHS/United States; GR: R21-AA018257/AA/NIAAA NIH HHS/United States; JID: 7603486; NIHMS508125; OID: NLM: NIHMS508125; OID: NLM: PMC3773209; OTO: NOTNLM; 2013/02/10 [received]; 2013/06/13 [revised];
Place of Publication
England
ISSN/ISBN
1873-6327; 0306-4603
Accession Number
PMID: 23934004
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1016/j.addbeh.2013.07.006 [doi]
Output Language
Unknown(0)
PMID
23934004
Abstract
Better understanding of the temporal sequence of hookah, cigarette, and marijuana use will help to inform smoking prevention efforts. To address this gap in the literature, we assessed all three of these smoking behaviors in a sample of 424 first-year college women. Using a longitudinal design, we investigated whether hookah use predicts initiating/resuming cigarette and/or initiating marijuana use, and whether cigarette and/or marijuana use predicts initiating hookah use. Participants (67% White, M age = 18.1 years) completed nine monthly surveys. The initial (i.e., baseline) survey assessed demographics, sensation-seeking, impulsivity, and pre-college substance use. Follow-up surveys assessed past-month substance use; outcomes were initiating/resuming cigarette use, initiating marijuana use, and initiating hookah use during the first year of college. We controlled for sensation-seeking, impulsivity, binge drinking, and other smoking behaviors in our multivariate logistic regression models. The results showed that (a) pre-college hookah use predicted initiating/resuming cigarette use; (b) pre-college marijuana use predicted initiation of hookah tobacco smoking; and (c) pre-college cigarette use predicted neither hookah nor marijuana initiation. The findings highlight the co-occurrence of smoking behaviors as well as the need for bundling preventive interventions so that they address hookah, cigarette, and marijuana use.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Fielder,R.L., Carey,K.B., Carey,M.P.
Original/Translated Title
URL
Date of Electronic
20130720
PMCID
PMC3773209
Editors
|
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| Cigarette and waterpipe smoking associated knowledge and behaviour among medical students in Lebanon | 2013 | College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, National Guard Health Affairs, King Abdulaziz Medical City, Riyadh, Saudi Arabia. jradiho@ngha.med.sa | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
Periodical, Abbrev.
East.Mediterr.Health J.
Pub Date Free Form
Oct
Volume
19
Issue
10
Start Page
861
Other Pages
868
Notes
JID: 9608387; ppublish
Place of Publication
Egypt
ISSN/ISBN
1020-3397; 1020-3397
Accession Number
PMID: 24313150
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
24313150
Abstract
As future physicians capable of controlling tobacco dependence in the population, medical students are considered a main target for tobacco control interventions. This cross-sectional study reported on the prevalence of tobacco use (cigarettes and waterpipes) and associated knowledge and behaviour among 6th-year medical students in 2009-2010 from 6 medical schools in Lebanon. The self-administered questionnaire based on the Global Health Professional Survey (GHPSS) core questions also enquired about training in tobacco cessation approaches. All enrolled students were asked to participate; the response rate was 191/354 (54.3%). The prevalence of tobacco use was 26.3% for cigarettes and 29.5% for waterpipes. Smoking waterpipes was the only significant predictor for cigarette smoking and there was no difference by sex and socioeconomic status. A minority reported ever receiving any formal training in treatment approaches for tobacco dependence. Medical schools should include tobacco dependence treatment training programmes in their curriculum and discourage tobacco use.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Jradi,H., Wewers,M.E., Pirie,P.R., Binkley,P.F., Ferketich,K.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
|
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| Impact of tobacco-related health warning labels across socioeconomic, race and ethnic groups: results from a randomized web-based experiment | 2013 | Department of Research and Evaluation, Legacy Foundation, Washington, DC, USA. jcantrell@legacyforhealth.org | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
PloS one
Periodical, Abbrev.
PLoS One
Pub Date Free Form
Volume
8
Issue
1
Start Page
e52206
Other Pages
Notes
LR: 20150219; JID: 101285081; OID: NLM: PMC3544861; 2012/05/18 [received]; 2012/11/14 [accepted]; 2013/01/14 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1932-6203; 1932-6203
Accession Number
PMID: 23341895
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.1371/journal.pone.0052206 [doi]
Output Language
Unknown(0)
PMID
23341895
Abstract
BACKGROUND: The U.S. Family Smoking Prevention and Tobacco Control Act of 2009 requires updating of the existing text-only health warning labels on tobacco packaging with nine new warning statements accompanied by pictorial images. Survey and experimental research in the U.S. and other countries supports the effectiveness of pictorial health warning labels compared with text-only warnings for informing smokers about the risks of smoking and encouraging cessation. Yet very little research has examined differences in reactions to warning labels by race/ethnicity, education or income despite evidence that population subgroups may differ in their ability to process health information. The purpose of the present study was to evaluate the potential impact of pictorial warning labels compared with text-only labels among U.S. adult smokers from diverse racial/ethnic and socioeconomic subgroups. METHODS/FINDINGS: Participants were adult smokers recruited from two online research panels (n = 3,371) into a web-based experimental study to view either the new pictorial warnings or text-only warnings. Participants viewed the labels and reported their reactions. Adjusted regression models demonstrated significantly stronger reactions for the pictorial condition for each outcome salience (b = 0.62, p<.001 perceived="" impact="" p="" credibility="" ci="1.22-1.62)," and="" intention="" to="" quit="" no="" significant="" results="" were="" found="" for="" interactions="" between="" condition="" race="" education="" or="" income.="" the="" only="" exception="" concerned="" outcome="" where="" condition-by-education="" interaction="" was="" nearly="" conclusions:="" findings="" suggest="" that="" greater="" of="" pictorial="" warning="" label="" compared="" text-only="" is="" consistent="" across="" diverse="" racial="" socioeconomic="" populations.="" given="" their="" great="" reach="" health="" labels="" may="" be="" one="" few="" tobacco="" control="" policies="" have="" potential="" reduce="" communication="" inequalities="" groups.="" establish="" strong="" on="" packaging="" instrumental="" in="" reducing="" toll="" epidemic="" particularly="" within="" vulnerable="" communities.="">
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Cantrell,J., Vallone,D.M., Thrasher,J.F., Nagler,R.H., Feirman,S.P., Muenz,L.R., He,D.Y., Viswanath,K.
Original/Translated Title
URL
Date of Electronic
20130114
PMCID
PMC3544861
Editors
|
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| Tobacco use in older adults in Ghana: sociodemographic characteristics, health risks and subjective wellbeing | 2013 | Department of Community Health, University of Ghana Medical School, College of Health Sciences, Room 46, P, O, Box 4236, Korle-Bu, Accra, Ghana. aeyawson@yahoo.com. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC public health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
20-Oct
Volume
13
Issue
Start Page
979
Other Pages
2458-13-979
Notes
GR: OGHA 04034785/PHS HHS/United States; GR: R01 AG034479-64401A1/AG/NIA NIH HHS/United States; GR: Y1-AG-1005-01/AG/NIA NIH HHS/United States; GR: YA1323-08-CN-0020/CN/NCI NIH HHS/United States; JID: 100968562; OID: NLM: PMC3924352; 2013/08/14 [received]
Place of Publication
England
ISSN/ISBN
1471-2458; 1471-2458
Accession Number
PMID: 24138966
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM
DOI
10.1186/1471-2458-13-979 [doi]
Output Language
Unknown(0)
PMID
24138966
Abstract
BACKGROUND: Tobacco use over the life-course threatens to increase disease burden in older adulthood, including lower income countries like Ghana. This paper describes demographic, socioeconomic, health risks and life satisfaction indices related to tobacco use among older adults in Ghana. METHODS: This work was based on the World Health Organization's multi-country Study on global AGEing and adult health (SAGE), conducted in six countries including Ghana. Wave one of SAGE in Ghana was conducted in 2007-2008 as collaboration between WHO and the University of Ghana Medical School through the Department of Community Health. A nationally representative sample of 4305 older adults aged 50 years and above were interviewed. Associations between tobacco consumption and sociodemographic, socioeconomic, health risk and life satisfaction were evaluated using chi-square and odds ratio (OR). Logistic regression analyses, adjusted for age, sex and other variables, were conducted to determine predictors of tobacco consumption in older persons. RESULTS: Overall prevalence of current daily smokers among older adults in Ghana was 7.6%. Tobacco use (i.e. ever used tobacco) was associated with older males, (AOR = 1.10, CI 1.05-1.15), older adults residing in rural locations (AOR = 1.37, CI 1.083-1.724), and older adults who used alcohol (AOR = 1.13, CI 0.230-2.418). Tobacco use was also associated (although not statistically significant per p-values) with increased self-reporting of angina, arthritis, asthma, chronic lung disease, depression, diabetes, hypertension, and stroke. Older adults who used tobacco and with increased health risks, tended to be without health insurance (AOR = 1.41, CI 1.111-1.787). Satisfaction with life and daily living was much lower for those who use tobacco. Regional differences existed in tobacco use; the three northern regions (Upper East, Northern and Upper West) had higher proportions of tobacco use among older adults in the country. Quitting tobacco use was higher in the 70+ years age group, in women, among urban residents and in those with at least secondary education. Quitting tobacco use also increased with increasing income levels. CONCLUSIONS: Tobacco use among older adults in Ghana was associated with older men living in rural locations, chronic ill-health and reduced life satisfaction. A high proportion of older adults have stopped using tobacco, demonstrating the possibilities for effective public health interventions. Health risk reduction strategies through targeted anti-smoking health campaigns, improvement in access to health and social protection (such as health insurance) will reduce health risks among older persons who use tobacco.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Yawson,A.E., Baddoo,A., Hagan-Seneadza,N.A., Calys-Tagoe,B., Hewlett,S., Dako-Gyeke,P., Mensah,G., Minicuci,N., Naidoo,N., Chatterji,S., Kowal,P., Biritwum,R.
Original/Translated Title
URL
Date of Electronic
20131020
PMCID
PMC3924352
Editors
|
|||
| Barrett esophagus and risk of esophageal cancer: a clinical review | 2013 | VA North Texas Healthcare System, Dallas, Texas, USA. sjspechler@aol.com | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Jama
Periodical, Abbrev.
JAMA
Pub Date Free Form
14-Aug
Volume
310
Issue
6
Start Page
627
Other Pages
636
Notes
LR: 20140917; JID: 7501160; ppublish
Place of Publication
United States
ISSN/ISBN
1538-3598; 0098-7484
Accession Number
PMID: 23942681
Language
eng
SubFile
Clinical Conference; Journal Article; Review; AIM; IM
DOI
10.1001/jama.2013.226450 [doi]
Output Language
Unknown(0)
PMID
23942681
Abstract
IMPORTANCE: Barrett esophagus, a complication of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma, a tumor that has increased in incidence more than 7-fold over the past several decades. Controversy exists regarding the issues of endoscopic screening and surveillance for Barrett esophagus, treatment for the underlying GERD, and the role of endoscopic eradication therapy. OBJECTIVES: To review current concepts on the pathogenesis, diagnosis, and treatment of Barrett esophagus; to discuss the importance of dysplasia and the role of endoscopic eradication therapy for its treatment; and to review current management guidelines. EVIDENCE REVIEW: MEDLINE and the Cochrane Library were searched from 1984 to April 2013. Additional citations were obtained by reviewing references from selected research and review articles. FINDINGS: Risk factors for cancer in Barrett esophagus include chronic GERD, hiatal hernia, advanced age, male sex, white race, cigarette smoking, and obesity with an intra-abdominal body fat distribution. The annual risk of esophageal cancer is approximately 0.25% for patients without dysplasia and 6% for patients with high-grade dysplasia. High-quality studies have found no significant differences in cancer incidence for patients with Barrett esophagus whose GERD is treated medically or surgically. Endoscopic eradication therapy with radiofrequency ablation significantly reduces the frequency of progression to cancer for patients with high-grade dysplasia. CONCLUSIONS AND RELEVANCE: Endoscopic screening is recommended for patients with multiple risk factors for cancer in Barrett esophagus. For patients with Barrett esophagus without dysplasia, endoscopic surveillance at intervals of 3 to 5 years is recommended, and GERD is treated much as it is for patients without Barrett esophagus. Endoscopic eradication therapy is the treatment of choice for high-grade dysplasia and is an option for low-grade dysplasia. Endoscopic eradication therapy is not recommended for the general population of patients with nondysplastic Barrett esophagus.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Spechler,S.J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
|
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