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Syngonanthus nitens Bong. (Rhul.)-Loaded Nanostructured System for Vulvovaginal Candidiasis Treatment 2016 Department of Biological Sciences, School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, Sao Paulo 14800-903, Brazil. matheusramos_91@hotmail.com.; Department of Biological Sciences, School of Pharmaceutical Sciences, UNESP-Univ Est
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Journal Article
Periodical, Full
International journal of molecular sciences
Periodical, Abbrev.
Int.J.Mol.Sci.
Pub Date Free Form
22-Aug
Volume
17
Issue
8
Start Page
E1368
Other Pages
Notes
LR: 20160824; JID: 101092791; OTO: NOTNLM; 2016/05/24 [received]; 2016/06/28 [revised]; 2016/06/30 [accepted]; epublish
Place of Publication
ISSN/ISBN
1422-0067; 1422-0067
Accession Number
PMID: 27556451
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
E1368 [pii]
Output Language
Unknown(0)
PMID
27556451
Abstract
Herbal-loaded drug delivery nanotechnological systems have been extensively studied recently. The antimicrobial activity of medicinal plants has shown better pharmacological action when such plants are loaded into a drug delivery system than when they are not loaded. Syngonanthus nitens Bong. (Rhul.) belongs to the Eriocaulaceae family and presents antiulcerogenic, antioxidant, antibacterial, and antifungal activity. The aim of this study was to evaluate the antifungal activity of Syngonanthus nitens (S. nitens) extract that was not loaded (E) or loaded (SE) into a liquid crystal precursor system (S) for the treatment of vulvovaginal candidiasis (VVC) with Candida albicans. The minimal inhibitory concentration (MIC) was determined by the microdilution technique. Additionally, we performed hyphae inhibition and biofilm tests. Finally, experimental candidiasis was evaluated in in vivo models with Wistar female rats. The results showed effective antifungal activity after incorporation into S for all strains tested, with MICs ranging from 31.2 to 62.5 mug/mL. Microscopic observation of SE revealed an absence of filamentous cells 24 h of exposure to a concentration of 31.2 mug/mL. E demonstrated no effective action against biofilms, though SE showed inhibition against biofilms of all strains. In the in vivo experiment, SE was effective in the treatment of infection after only two days of treatment and was more effective than E and amphotericin B. The S. nitens is active against Candida albicans (C. albicans) and the antifungal potential is being enhanced after incorporation into liquid crystal precursor systems (LCPS). These findings represent a promising application of SE in the treatment of VVC.
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Database
Publisher
Data Source
Authors
Dos Santos Ramos,M.A., de Toledo,L.G., Calixto,G.M., Bonifacio,B.V., de Freitas Araujo,M.G., Dos Santos,L.C., de Almeida,M.T., Chorilli,M., Bauab,T.M.
Original/Translated Title
URL
Date of Electronic
20160822
PMCID
Editors
Cannabis "bong": A frequent, original and dangerous way of consumption 2016 Service des maladies respiratoires, HIA de Clermont-Tonnerre, rue du Colonel-Fonferrier, 29240 Brest cedex 9, France. Electronic address: nicolas.paleiron@free.fr.; Service des maladies respiratoires, HIA de Clermont-Tonnerre, rue du Colonel-Fonferrier, 2
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Revue de pneumologie clinique
Periodical, Abbrev.
Rev.Pneumol.Clin.
Pub Date Free Form
May
Volume
72
Issue
3
Start Page
195
Other Pages
199
Notes
CI: Copyright (c) 2016; JID: 8406312; OTO: NOTNLM; 2015/08/18 [received]; 2016/02/26 [accepted]; 2016/04/22 [aheadofprint]; ppublish
Place of Publication
France
ISSN/ISBN
0761-8417; 0761-8417
Accession Number
PMID: 27113618
Language
fre
SubFile
English Abstract; Journal Article; IM
DOI
10.1016/j.pneumo.2016.02.004 [doi]
Output Language
Unknown(0)
PMID
27113618
Abstract
The bong is a water pipe craft, used to smoke tobacco or cannabis. The benefit of consuming cannabis as a "bang" is based on the intensity and speed of the effect. The cannabis intoxication can then be associated with disorders of sensory functions, the type of distortion of perceptions or hallucinations, often accompanied by intense anxiety. Bong cannabis consumption appears to be responsible for specific side effects (especially hemoptysis), possibly related to the importance of inhalation of products of combustion of cannabis and combustion of plastic parts used in its manufacture.
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Links
Book Title
Database
Publisher
Elsevier Masson SAS
Data Source
Authors
Paleiron,N., Andre,M., Durand,M., Tromeur,C., Giacardi,C., Grassin,F., Vinsonneau,U.
Original/Translated Title
Le > de cannabis, un mode de consommation original, frequent et dangereux
URL
Date of Electronic
20160422
PMCID
Editors
Chronological Review on Scientific Findings of Bonghan System and Primo Vascular System 2016 Department of Chemical Engineering, University of Louisville, Louisville, KY, 40292, USA. kyung.kang@louisville.edu.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Advances in Experimental Medicine and Biology
Periodical, Abbrev.
Adv.Exp.Med.Biol.
Pub Date Free Form
Volume
923
Issue
Start Page
301
Other Pages
309
Notes
JID: 0121103; OTO: NOTNLM; ppublish
Place of Publication
United States
ISSN/ISBN
0065-2598; 0065-2598
Accession Number
PMID: 27526157
Language
eng
SubFile
Journal Article; IM
DOI
10.1007/978-3-319-38810-6_40 [doi]
Output Language
Unknown(0)
PMID
27526157
Abstract
In 1962, Bonghan Kim in North Korea published a report on a new vascular system in mammals, which he claimed as the acupuncture meridian. He soon named it the Bonghan System. Between 1962 and 1965, he published five reports, with detailed descriptions on the system. Kim also described the self-regenerating nature of a unique cell type Sanals in the system and these cells are now confirmed to be a type of stem cells. According to his findings, the system appears to have vital roles in maintaining mammalian lives. Kim disappeared in around 1965 and the research on this system also completely stopped. In 2002, Kwang-Sup Soh reported re-discovery of the system and, since then, his team has been leading the research on the system. The Soh team has confirmed many of Kim's findings to be valid, although so many of Kim's results are still to be verified. In 2010, the system was renamed the Primo Vascular System (PVS). Soh and researchers trained by Soh have also been reporting new scientific facts on the system. The PVS exists throughout the entire body, including inside the blood and lymphatic vessels. Recent reports revealed more evidence for it to be the acupuncture meridian, where some acupuncture therapies are applied for the blood pressure control. Thus, the PVS is expected to have roles in the oxygen transport in tissues. Many study results also suggest that the PVS may have roles in body homeostasis and regeneration. This article chronologically reviews Kim's scientific findings on the Bonghan System, which were verified by the PVS scientists (after 2000), and also the new findings reported by the PVS scientists.
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Database
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Data Source
Authors
Kang,K.A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Community quarantine to interrupt Ebola virus transmission - Mawah Village, Bong County, Liberia, August-October, 2014 2015
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
MMWR.Morbidity and mortality weekly report
Periodical, Abbrev.
MMWR Morb.Mortal.Wkly.Rep.
Pub Date Free Form
27-Feb
Volume
64
Issue
7
Start Page
179
Other Pages
182
Notes
JID: 7802429; ppublish
Place of Publication
United States
ISSN/ISBN
1545-861X; 0149-2195
Accession Number
PMID: 25719679
Language
eng
SubFile
Journal Article; IM
DOI
mm6407a4 [pii]
Output Language
Unknown(0)
PMID
25719679
Abstract
On September 30, 2014, the Bong County health officer notified the county Ebola task force of a growing outbreak of Ebola virus disease (Ebola) in Mawah, a village of approximately 800 residents. During September 9-16, household quarantine had been used by the community in response to a new Ebola infection. Because the infection led to a local outbreak that grew during September 17-20, county authorities suggested community quarantine be considered, and beginning on approximately September 20, the Fuamah District Ebola Task Force (Task Force) engaged Mawah leaders to provide education about Ebola and to secure cooperation for the proposed measures. On September 30, Bong County requested technical assistance to develop strategies to limit transmission in the village and to prevent spread to other areas. The county health team, with support from the Task Force and CDC, traveled to Mawah on October 1 and identified approximately two dozen residents reporting symptoms consistent with Ebola. Because of an ambulance shortage, 2 days were required, beginning October 1, to transport the patients to an Ebola treatment unit in Monrovia. Community quarantine measures, consisting of restrictions on entering or leaving Mawah, regulated river crossings, and market closures, were implemented on October 1. Local leaders raised concerns about availability of medical care and food. The local clinic was reopened on October 11, and food was distributed on October 12. The Task Force reported a total of 22 cases of Ebola in Mawah during September 9-October 2, of which 19 were fatal. During October 3-November 21, no new cases were reported in the village. Involving community members during planning and implementation helped support a safe and effective community quarantine in Mawah.
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Database
Publisher
Data Source
Authors
Nyenswah,T., Blackley,D.J., Freeman,T., Lindblade,K.A., Arzoaquoi,S.K., Mott,J.A., Williams,J.N., Halldin,C.N., Kollie,F., Laney,A.S., Centers for Disease Control and Prevention (CDC)
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Chemical composition of the essential oil and fixed oil Bauhinia pentandra (Bong.) D. Dietr 2015 Departamento de Quimica Organica e Inorganica, Universidade Federal do Ceara, Fortaleza-CE, Brazil.; Departamento de Quimica Organica e Inorganica, Universidade Federal do Ceara, Fortaleza-CE, Brazil.; Departamento de Quimica Organica e Inorganica, Univer
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Pharmacognosy magazine
Periodical, Abbrev.
Pharmacogn Mag.
Pub Date Free Form
Oct
Volume
11
Issue
Suppl 2
Start Page
S362
Other Pages
4
Notes
JID: 101300403; OTO: NOTNLM; ppublish
Place of Publication
India
ISSN/ISBN
0973-1296; 0973-1296
Accession Number
PMID: 26664026
Language
eng
SubFile
Journal Article
DOI
10.4103/0973-1296.166015 [doi]
Output Language
Unknown(0)
PMID
26664026
Abstract
BACKGROUND: Bauhinia pentandrais popularly known as "mororo" and inhabits the Caatinga and Savannah biomes. OBJECTIVE: This paper reports the chemical composition of the essential and fatty oils of the leaves from B. pentandra. MATERIALS AND METHODS: The essential oil was obtained by hydrodistillation and the fixed oil by extraction with hexane, followed by saponification with KOH/MeOH, and methylation using MeOH/HCl. The constituents were analyzed by gas chromatography-mass spectrometry. RESULTS: The major constituent of the essential oil was the phytol (58.78% +/-8.51%), and of the fatty oil were palmitic (29.03%), stearic (28.58%) and linolenic (10.53%) acids. CONCLUSION: Of the compounds identified in the essential oil, three are first reported in this species, and this is the first record of the chemical composition of the fixed oil.
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Database
Publisher
Data Source
Authors
de Almeida,M.C., Souza,L.G., Ferreira,D.A., Monte,F.J., Braz-Filho,R., de Lemos,T.L.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4653348
Editors
Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei 2015 Department of Biological Sciences, School of Pharmaceutical Sciences, Sao Paulo State University, Araraquara, Brazil.; Department of Drugs and Medicine, School of Pharmaceutical Sciences, Sao Paulo State University, Araraquara, Brazil.; Department of Infe
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of nanomedicine
Periodical, Abbrev.
Int.J.Nanomedicine
Pub Date Free Form
16-Dec
Volume
10
Issue
Start Page
7455
Other Pages
7466
Notes
LR: 20160102; JID: 101263847; OID: NLM: PMC4687718; OTO: NOTNLM; 2015 [ecollection]; 2015/12/16 [epublish]; epublish
Place of Publication
New Zealand
ISSN/ISBN
1178-2013; 1176-9114
Accession Number
PMID: 26719688
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.2147/IJN.S92638 [doi]
Output Language
Unknown(0)
PMID
26719688
Abstract
Vaginal infections caused by Candida krusei are a problem of extreme complexity due to the intrinsic resistance to azole drugs. The species Syngonanthus nitens (Bong.) Ruhland is a plant of the Eriocaulaceae family that has demonstrated promising antifungal activity. In phyto-formulation research, liquid crystal precursor mucoadhesive systems (LCPM) stand out as drug delivery systems for vaginal administration because they increase the activity and overcome the problems associated with plant-based medicines. Therefore, the objective of this study was to evaluate the potential of the methanolic extract of scapes of S. nitens (S. nitens extract [SNE]) and an SNE-loaded LCPM against C. krusei as prophylaxis for vulvovaginal candidiasis. LCPM formulation developed consisted of oleic acid as the oil phase (50% w/w), polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol (40% w/w) as the surfactant and a polymeric dispersion containing 2.5% Carbopol((R)) 974P and 2.5% polycarbophil (10% w/w) as the aqueous phase. LCPM formulation developed was characterized using polarized light microscopy, rheological analysis, and in vitro mucoadhesive studies. Different strains of C. krusei, including one standard strain (American Type Culture Collection 6258) and three clinically isolated strains from the vaginal region (CKV1, 2, and 3), were used to determine the minimum inhibitory concentration, inhibition of biofilms, and time kill. The in vivo prophylaxis assay was performed using the standard strain (American Type Culture Collection 6258). The analyses of F by polarized light microscopy and rheology showed isotropy; however, the addition of 100% artificial vaginal mucus (F100) made it more viscous and anisotropic. Moreover, the mucoadhesive strength was modified, which makes F an excellent formulation for vaginal applications. SNE was active against all strains studied, with minimum inhibitory concentration values ranging from 125 to 62.5 microg/mL; after incorporating SNE into F (FE), these values decreased to 62.5 to 31.2 microg/mL, demonstrating that incorporation into the formulation potentiated the action of SNE. Additionally, the time kill assays showed that both forms of SNE were capable of controlling growth, thereby suggesting a possible fungistatic mechanism. Unloaded SNE was not active against C. krusei biofilms, but FE was active against a clinical strain (CKV2). In vivo analysis showed that FE was able to prevent the development of infection following 10 days of administration. We concluded that the formulation developed in this study was an important vehicle for the delivery of SNE based on the improved antifungal activity in all in vitro and in vivo analyses. Furthermore, the extract incorporated into the system may serve as an important prophylactic agent against vaginal infections caused by C. krusei.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
dos Santos Ramos,M.A., Calixto,G., de Toledo,L.G., Bonifacio,B.V., dos Santos,L.C., de Almeida,M.T., Chorilli,M., Bauab,T.M.
Original/Translated Title
URL
Date of Electronic
20151216
PMCID
PMC4687718
Editors
Primo-Vascular System as Presented by Bong Han Kim 2015 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn, AL 36849, USA ; School of Kinesiology, Auburn University, Auburn, AL 36849, USA ; Edward Via College of Osteopathic Medicine, Auburn, AL 36849, USA.; Department of
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Evidence-based complementary and alternative medicine : eCAM
Periodical, Abbrev.
Evid Based.Complement.Alternat Med.
Pub Date Free Form
Volume
2015
Issue
Start Page
361974
Other Pages
Notes
LR: 20150919; JID: 101215021; OID: NLM: PMC4562093; 2014/09/29 [received]; 2015/01/01 [revised]; 2015/01/05 [accepted]; 2015/08/25 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1741-427X; 1741-427X
Accession Number
PMID: 26379743
Language
eng
SubFile
Journal Article; Review
DOI
10.1155/2015/361974 [doi]
Output Language
Unknown(0)
PMID
26379743
Abstract
In the 1960s Bong Han Kim discovered and characterized a new vascular system. He was able to differentiate it clearly from vascular blood and lymph systems by the use of a variety of methods, which were available to him in the mid-20th century. He gave detailed characterization of the system and created comprehensive diagrams and photographs in his publications. He demonstrated that this system is composed of nodes and vessels, and it was responsible for tissue regeneration. However, he did not disclose in detail his methods. Consequently, his results are relatively obscure from the vantage point of contemporary scientists. The stains that Kim used had been perfected and had been in use for more than 100 years. Therefore, the names of the stains were directed to the explicit protocols for the usage with the particular cells or molecules. Traditionally, it was not normally necessary to describe the method used unless it is significantly deviated from the original method. In this present work, we have been able to disclose staining methods used by Kim.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Vodyanoy,V., Pustovyy,O., Globa,L., Sorokulova,I.
Original/Translated Title
URL
Date of Electronic
20150825
PMCID
PMC4562093
Editors
Cluster of Ebola Virus Disease, Bong and Montserrado Counties, Liberia 2015
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Emerging infectious diseases
Periodical, Abbrev.
Emerg.Infect.Dis.
Pub Date Free Form
Jul
Volume
21
Issue
7
Start Page
1253
Other Pages
1256
Notes
LR: 20150701; JID: 9508155; OID: NLM: PMC4480411; OTO: NOTNLM; ppublish
Place of Publication
United States
ISSN/ISBN
1080-6059; 1080-6040
Accession Number
PMID: 26079309
Language
eng
SubFile
Case Reports; Journal Article; IM
DOI
10.3201/eid2107.150511 [doi]
Output Language
Unknown(0)
PMID
26079309
Abstract
Lack of trust in government-supported services after the death of a health care worker with symptoms of Ebola resulted in ongoing Ebola transmission in 2 Liberia counties. Ebola transmission was facilitated by attempts to avoid cremation of the deceased patient and delays in identifying and monitoring contacts.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Nyenswah,T.G., Fallah,M., Calvert,G.M., Duwor,S., Hamilton,E.D., Mokashi,V., Arzoaquoi,S., Dweh,E., Burbach,R., Dlouhy,D., Oeltmann,J.E., Moonan,P.K.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4480411
Editors
Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity 2014 Microbiology Institute, Virology Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. davisf@micro.ufrj.br.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Parasites & vectors
Periodical, Abbrev.
Parasit.Vectors
Pub Date Free Form
28-Mar
Volume
7
Issue
Start Page
130
Other Pages
3305-7-130
Notes
LR: 20150514; JID: 101462774; 0 (Antioxidants); 0 (Antiviral Agents); 0 (Glycosides); 9IKM0I5T1E (Quercetin); OID: NLM: PMC3973022; 2014/01/20 [received]; 2014/03/12 [accepted]; 2014/03/28 [aheadofprint]; epublish
Place of Publication
England
ISSN/ISBN
1756-3305; 1756-3305
Accession Number
PMID: 24678592
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1186/1756-3305-7-130 [doi]
Output Language
Unknown(0)
PMID
24678592
Abstract
BACKGROUND: The arthropod-borne Mayaro virus (MAYV) causes 'Mayaro fever', a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Recently, MAYV has attracted attention due to its likely urbanization. Currently, there are no licensed drugs against most mosquito-transmitted viruses. Here, we investigated the in vitro anti-MAYV activity of the flavonoids quercetin and its derivatives from the Brazilian shrub Bauhinia longifolia (Bong.) Steud. METHODS: Flavonoids were purified by chromatographic fractionation from leaf extracts of B. longifolia and chemically identified as quercetin and quercetin glycosides using spectroscopic techniques. Cytotoxicity of purified flavonoids and of EtOAc- and n-BuOH-containing flavonoid mixtures was measured by the dye-uptake assay while their antiviral activity was evaluated by a virus yield inhibition assay. RESULTS: The following flavonoids were purified from B. longifolia leaves: non-glycosylated quercetin and its glycosides guaijaverin, quercitrin, isoquercitrin, and hyperin. EtOAc and n-BuOH fractions containing these flavonoids demonstrated the highest antiviral activity of all tested substances, while quercetin had the highest antiviral activity amongst purified flavonoids. Quercetin, EtOAc, or n-BuOH fractions inhibited MAYV production by more than 90% at 25 mug/mL, displaying a stronger antiviral effect than the licensed antiviral ribavirin. A mixture of the isomers isoquercitrin and hyperin had a modest antiviral effect (IC90 = 104.9), while guaijaverin and quercitrin did not show significant antiviral activity. CONCLUSIONS: B. longifolia is a good source of flavonoids with anti-Mayaro virus activity. This is the first report of the activity of quercetin and its derivatives against an alphavirus.
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Database
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Data Source
Authors
dos Santos,A.E., Kuster,R.M., Yamamoto,K.A., Salles,T.S., Campos,R., de Meneses,M.D., Soares,M.R., Ferreira,D.
Original/Translated Title
URL
Date of Electronic
20140328
PMCID
PMC3973022
Editors
Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis 2013 * Biological Sciences Department, Faculty of Pharmaceutical Sciences.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Medical mycology
Periodical, Abbrev.
Med.Mycol.
Pub Date Free Form
Oct
Volume
51
Issue
7
Start Page
673
Other Pages
682
Notes
JID: 9815835; 0 (Antifungal Agents); 0 (Flavones); 0 (Ointments); 0 (Plant Extracts); 2013/06/13 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1460-2709; 1369-3786
Accession Number
PMID: 23758104
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.3109/13693786.2013.795294 [doi]
Output Language
Unknown(0)
PMID
23758104
Abstract
The purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis.
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Database
Publisher
Data Source
Authors
de Freitas Araujo,M.G., Pacifico,M., Vilegas,W., Dos Santos,L.C., Icely,P.A., Miro,M.S., Scarpa,M.V., Bauab,T.M., Sotomayor,C.E.
Original/Translated Title
URL
Date of Electronic
20130613
PMCID
Editors