WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Determinants of nonmedical use, abuse or dependence on prescription drugs, and use of substance abuse treatment	2013	Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, 1441 Moursund St, Houston, TX 77030, USA. v.bali4u@gmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Research in social & administrative pharmacy : RSAP Periodical, Abbrev. Res.Social Adm.Pharm. Pub Date Free Form May-Jun Volume 9 Issue 3 Start Page 276 Other Pages 287 Notes LR: 20150312; CI: Copyright (c) 2013; JID: 101231974; 0 (Prescription Drugs); EIN: Res Social Adm Pharm. 2013 Jul-Aug;9(4):495; 2011/09/18 [received]; 2012/04/15 [revised]; 2012/04/16 [accepted]; 2012/06/23 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1934-8150; 1551-7411 Accession Number PMID: 22727534 Language eng SubFile Journal Article; IM DOI 10.1016/j.sapharm.2012.04.008 [doi] Output Language Unknown(0) PMID 22727534 Abstract BACKGROUND: Previous studies have found a negative association between health insurance and nonmedical use of prescription drugs (NMUPD), and abuse or dependence on prescription drugs (ADPD); and mixed associations between health insurance and use of substance abuse treatment (SAT). However, effect of health insurance in the specific subgroups of population is largely unknown. OBJECTIVE: To estimate the relationship between health insurance and (1) NMUPD, (2) ADPD, and (3) use of SAT services among 12-64 years old, noninstitutionalized individuals and to see if these relationships are different in different subgroups of population. METHODS: This study used cross-sectional survey data from 2007 National Survey on Drug Use and Health. Bivariate and multiple logistic regression analyses were conducted. RESULTS: In 2007, self-reported prevalence of NMUPD was approximately 10% (N=15,509,703). In multivariate analysis, NMUPD was negatively associated with health insurance, age, race other than non-Hispanic White, education, marital status, and income ($40,000-$74,999). Past year use of tobacco and alcohol were positively associated with NMUPD. Among those with private health insurance, Hispanics and individuals with family income less than $20,000 and $40,000-$74,999 were more likely prone to NMUPD than others. High school graduates with public health insurance were less likely prone to NMUPD. Approximately, 13% of nonmedical users reported ADPD (N=2,011,229). Health insurance and age were negatively associated with ADPD. However, people who were unmarried, reported fair/poor health, and used tobacco were more likely to report ADPD. Lastly, the use of substance abuse treatment programs was approximately 73% and 76% between NMUPD and ADPD population, respectively. Health insurance was not associated with use of substance abuse treatment. Individuals with high school education were 2.6 times more likely to use substance abuse treatment than the college graduates. Additionally, no significant interaction effects were found between health insurance, and sociodemographic factors on ADPD and the use of substance abuse treatment. CONCLUSIONS: Health insurance had a differential impact on NMUPD only. Among privately insured, Hispanics and individuals reporting family income less than $20,000 were more likely to engage in NMUPD. There is a need to better understand and monitor the use of prescription drugs among these groups. This knowledge can help in developing public health programs and policies that discourage NMUPD among these individuals. Descriptors Links Book Title Database Publisher Elsevier Inc Data Source Authors Bali,V., Raisch,D.W., Moffett,M.L., Khan,N. Original/Translated Title URL Date of Electronic 20120623 PMCID Editors
N'-{(E)-[5-(Hy-droxy-meth-yl)furan-2-yl]methyl-idene}pyridine-4-carbohydrazide dihydrate	2013	Department of Chemistry and Research Centre, PRNSS College, Mattanur 670 702, Kannur, Kerala, India.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 27-Jul Volume 69 Issue Pt 8 Start Page o1342 Other Pages 3 Notes LR: 20140124; JID: 101089178; OID: NLM: PMC3793823; 2013/08/01 [ecollection]; 2013/06/30 [received]; 2013/07/20 [accepted]; 2013/07/27 [epublish]; epublish Place of Publication United States ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 24109410 Language eng SubFile Journal Article DOI 10.1107/S1600536813020114 [doi] Output Language Unknown(0) PMID 24109410 Abstract In the title compound, C12H11N3O3.2H2O, the dihedral angle formed by the planes of the pyridine and the furan rings of the organic carbohydrazide mol-ecule is 4.66 (7) degrees . In the crystal, these mol-ecules form stacks along the b-axis direction, neighbouring mol-ecules within each stack being related by inversion and the shortest distance between the centroids of the pyridine and furan rings being 3.714 (1) A. Mol-ecules from neighboring stacks are linked by pairs of N-Hcdots, three dots, centeredO hydrogen bonds. The water mol-ecules fill the channels between the stacks being linked by O-Hcdots, three dots, centeredO hydrogen bonds into helices along [010]. Besides this, water mol-ecules are involved in O-Hcdots, three dots, centeredN and O-Hcdots, three dots, centeredO hydrogen bonds with the carbohydrazide mol-ecules, thus forming a three-dimensional network, augmented by weak C-Hcdots, three dots, centeredO interactions. Descriptors Links Book Title Database Publisher Data Source Authors Prasanna,M.K., Sithambaresan,M., Pradeepkumar,K., Kurup,M.R. Original/Translated Title URL Date of Electronic 20130727 PMCID PMC3793823 Editors
Group hypnosis vs. relaxation for smoking cessation in adults: a cluster-randomised controlled trial	2013	Swiss Research Institute for Public Health and Addiction ISGF, University of Zurich, Konradstrasse 32, Postfach, 8031 Zurich, Switzerland. maria.dickson@isgf.uzh.ch.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 23-Dec Volume 13 Issue Start Page 1227 Other Pages 2458-13-1227 Notes LR: 20150422; ISRCTN/ISRCTN72839675; JID: 100968562; OID: NLM: PMC3878029; 2013/09/26 [received]; 2013/12/20 [accepted]; 2013/12/23 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 24365274 Language eng SubFile Comparative Study; Journal Article; Randomized Controlled Trial; IM DOI 10.1186/1471-2458-13-1227 [doi] Output Language Unknown(0) PMID 24365274 Abstract BACKGROUND: Despite the popularity of hypnotherapy for smoking cessation, the efficacy of this method is unclear. We aimed to investigate the efficacy of a single-session of group hypnotherapy for smoking cessation compared to relaxation in Swiss adult smokers. METHODS: This was a cluster-randomised, parallel-group, controlled trial. A single session of hypnosis or relaxation for smoking cessation was delivered to groups of smokers (median size = 11). Participants were 223 smokers consuming >/= 5 cigarettes per day, willing to quit and not using cessation aids (47.1% females, M = 37.5 years [SD = 11.8], 86.1% Swiss). Nicotine withdrawal, smoking abstinence self-efficacy, and adverse reactions were assessed at a 2-week follow-up. The main outcome, self-reported 30-day point prevalence of smoking abstinence, was assessed at a 6-month follow up. Abstinence was validated through salivary analysis. Secondary outcomes included number of cigarettes smoked per day, smoking abstinence self-efficacy, and nicotine withdrawal. RESULTS: At the 6-month follow up, 14.7% in the hypnosis group and 17.8% in the relaxation group were abstinent. The intervention had no effect on smoking status (p = .73) or on the number of cigarettes smoked per day (p = .56). Smoking abstinence self-efficacy did not differ between the interventions (p = .14) at the 2-week follow-up, but non-smokers in the hypnosis group experienced reduced withdrawal (p = .02). Both interventions produced few adverse reactions (p = .81). CONCLUSIONS: A single session of group hypnotherapy does not appear to be more effective for smoking cessation than a group relaxation session. TRIAL REGISTRATION: Current Controlled Trials ISRCTN72839675. Descriptors Links Book Title Database Publisher Data Source Authors Dickson-Spillmann,M., Haug,S., Schaub,M.P. Original/Translated Title URL Date of Electronic 20131223 PMCID PMC3878029 Editors
Efficacy of an experiential, dissonance-based smoking intervention for college students delivered via the internet	2013	Department of Health Outcomes and Behavior.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of consulting and clinical psychology Periodical, Abbrev. J.Consult.Clin.Psychol. Pub Date Free Form Oct Volume 81 Issue 5 Start Page 810 Other Pages 820 Notes LR: 20160303; GR: P30 CA076292/CA/NCI NIH HHS/United States; JID: 0136553; NIHMS731776; OID: NLM: NIHMS731776; OID: NLM: PMC4640469; 2013/05/13 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1939-2117; 0022-006X Accession Number PMID: 23668667 Language eng SubFile Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM DOI 10.1037/a0032952 [doi] Output Language Unknown(0) PMID 23668667 Abstract OBJECTIVE: College represents a window of opportunity to reach the sizeable number of cigarette smokers who are vulnerable to lifelong smoking. The underutilization of typical cessation programs suggests the need for novel and more engaging approaches for reaching college smokers. The aim of the present study was to test the efficacy of a dissonance-enhancing, Web-based experiential intervention for increasing smoking cessation motivation and behavior. METHOD: We used a 4-arm, randomized design to examine the efficacy of a Web-based, experiential smoking intervention (Web-Smoke). The control conditions included a didactic smoking intervention (Didactic), a group-based experiential intervention (Group), and a Web-based nutrition experiential intervention (Web-Nutrition). We recruited 341 college smokers. Primary outcomes were motivation to quit, assessed immediately postintervention, and smoking abstinence at 1 and 6 months following the intervention. RESULTS: As hypothesized, the Web-Smoke intervention was more effective than control groups in increasing motivation to quit. At 6-month follow-up, the Web-Smoke intervention produced higher rates of smoking cessation than the Web-Nutrition control intervention. Daily smoking moderated intervention outcomes. Among daily smokers, the Web-Smoke intervention produced greater abstinence rates than both the Web-Nutrition and Didactic control conditions. CONCLUSION: Findings demonstrate the efficacy of a theory-based intervention delivered over the Internet for increasing motivation to quit and smoking abstinence among college smokers. The intervention has potential for translation and implementation as a secondary prevention strategy for college-aged smokers. (PsycINFO Database Record (c) 2013 APA, all rights reserved). Descriptors Links Book Title Database Publisher Data Source Authors Simmons,V.N., Heckman,B.W., Fink,A.C., Small,B.J., Brandon,T.H. Original/Translated Title URL Date of Electronic 20130513 PMCID PMC4640469 Editors
Effects of personality on risky driving behavior and accident involvement for Chinese drivers	2013	Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Traffic injury prevention Periodical, Abbrev. Traffic Inj.Prev. Pub Date Free Form Volume 14 Issue 6 Start Page 565 Other Pages 571 Notes LR: 20151119; JID: 101144385; ppublish Place of Publication England ISSN/ISBN 1538-957X; 1538-9588 Accession Number PMID: 23859184 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1080/15389588.2012.748903 [doi] Output Language Unknown(0) PMID 23859184 Abstract OBJECTIVE: Motor vehicle accidents are the leading cause of injury-related fatalities in China and pose the most serious threat to driving safety. Driver personality is considered as an effective predictor for risky driving behavior and accident liability. Previous studies have focused on the relationship between personality and risky driving behavior, but only a few of them have explored the effects of personality variables on accident involvement. In addition, few studies have examined the effects of personality on Chinese drivers' risky driving and accident involvement. The present study aimed to examine the effects of personality variables on Chinese drivers' unsafe driving behaviors and accident involvement. METHODS: Two hundred and twenty-four Chinese drivers aged 20 to 50 were required to complete questionnaires assessing their personality traits (anger, sensation-seeking, altruism, and normlessness), risky driving behaviors (aggressive violations, ordinary violations), and accident involvement (all accidents, serious accidents, at-fault accidents). Multivariate regression analyses, adjusting for gender, age, and overall mileage, were conducted to identify the personality traits related to risky driving behaviors and accident involvement. RESULTS: Participants' personality traits were found to be significantly correlated with both risky driving behavior and accident involvement. Specifically, the traits of anger and normlessness were effective predictors for aggressive violations. The traits of anger, sensation-seeking, normlessness, and altruism were effective predictors for ordinary violations. Moreover, altruism and normlessness were significant predictors for the total number of accidents participants had during the past 3 years. CONCLUSIONS: Consistent with previous studies, the present study revealed that personality traits play an important role in predicting Chinese drivers' risky driving behaviors. In addition, Chinese drivers' personality characteristics were also associated with accident involvement. Descriptors Links Book Title Database Publisher Data Source Authors Yang,J., Du,F., Qu,W., Gong,Z., Sun,X. Original/Translated Title URL Date of Electronic PMCID Editors
Self-perceived HIV risk and the use of risk reduction strategies among men who engage in transactional sex with other men in Ho Chi Minh City, Vietnam	2013	Harvard Medical School/Massachusetts General Hospital, Boston, Massachusetts, USA. mmimiaga@partners.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full AIDS Care Periodical, Abbrev. AIDS Care Pub Date Free Form Aug Volume 25 Issue 8 Start Page 1039 Other Pages 1044 Notes LR: 20150219; GR: 1 UL1 RR 025758-02/RR/NCRR NIH HHS/United States; GR: UL1 TR000170/TR/NCATS NIH HHS/United States; JID: 8915313; NIHMS451634; OID: NLM: NIHMS451634; OID: NLM: PMC3700653; 2012/12/20 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1360-0451; 0954-0121 Accession Number PMID: 23252673 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM; X DOI 10.1080/09540121.2012.748873 [doi] Output Language Unknown(0) PMID 23252673 Abstract An emerging HIV epidemic can be seen among men who have sex with men (MSM) in Vietnam, with prevalence as high as 18%. Transactional sex represents a risk factor for HIV transmission/acquisition among MSM globally, particularly in urban contexts, but remains largely underinvestigated in Ho Chi Minh City (HCMC), Vietnam. In 2010, 23 MSM who reported exchanging sex for money in the last month completed a brief survey and semistructured qualitative interview at The Life Centre, a non-governmental organization in HCMC, to assess sociodemographics, individual- and structural-level HIV risk factors and explore acceptable future prevention interventions. Participants' mean age was 24 years. Equal proportions of respondents self-identified as heterosexual/straight, homosexual/gay, and bisexual. Participants had a mean of 158 male clients in the past year, with a median of 60 male clients in the past year (interquartile range [IQR]=70) and reported inconsistent condom use and inaccurate perceptions of HIV risk. Nearly half of the sample reported engaging in unprotected anal sex with a male partner in the past 12 months and one-third with a male client. Major themes that emerged for HIV prevention interventions with male sex workers were those that: (1) focused on individual factors (drug and alcohol use, barriers to condom use, knowledge of asymptomatic STIs, enhancement of behavioral risk-reduction skills, and addressing concomitant mental health issues); (2) incorporated interpersonal and relational contexts (led by peer educators, built interpersonal skills, attended to partner type and intimacy dynamics); and (3) considered the exogenous environments in which individual choices/relationships operate (stigma of being MSM in Vietnam, availability of alternative economic opportunities, and varied sexual venues). HIV prevention efforts are needed that address the specific needs of MSM who engage in transactional sex in HCMC. Universally, MSM endorsed HIV prevention interventions, suggesting a need and desire for efforts in this context. Descriptors Links Book Title Database Publisher Data Source Authors Mimiaga,M.J., Reisner,S.L., Closson,E.F., Perry,N., Perkovich,B., Nguyen,T., Trang,N.N., Lan,H.X., Thien,D.D., Mayer,K.H., Colby,D. Original/Translated Title URL Date of Electronic 20121220 PMCID PMC3700653 Editors
N-[3a-(4-Bromo-phen-yl)-8b-hy-droxy-6,8-dimeth-oxy-3-phenyl-2,3,3a,8b-tetra-hydro -1H-cyclo-penta-[b]benzofuran-1-yl]formamide monohydrate	2013	Cristallographie, Resonance Magnetique et Modelisations (CRM2), UMR CNRS-UHP 7036, Institut Jean Barriol, Universite de Lorraine, BP 70239, Bd des Aiguillettes, 54506 Vandoeuvre-les-Nancy, France.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 1-Jan Volume 69 Issue Pt 1 Start Page o52 Other Pages 3 Notes LR: 20130418; JID: 101089178; OID: NLM: PMC3588239; 2012/11/22 [received]; 2012/12/03 [accepted]; 2012/12/08 [epublish]; ppublish Place of Publication United States ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 23476436 Language eng SubFile Journal Article DOI 10.1107/S1600536812049641 [doi] Output Language Unknown(0) PMID 23476436 Abstract In the title compound, C26H24BrNO5.H2O, a synthetic analogue of natural flavagline, the cyclo-pentane ring adopts an envelope conformation (the flap atom bearing the phenyl group) and the vicinal phenyl and bromo-phenyl groups are slightly shifted relative to each other [CPh-C-C-CPhBr = 36.3 (2) degrees ]. Intra-molecular N-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds form S(5) motifs. In the crystal, the organic and the water mol-ecules are linked by an O-Hcdots, three dots, centeredO hydrogen bond. Pairs of organic and water mol-ecules, located about inversion centers, inter-act through O-Hcdots, three dots, centeredO hydrogen bonds, forming R4(4)(20) and R4(4)(26) motifs, which together lead to C2(2)(9) motifs. The crystal packing is also characterized by N-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds between neighbouring organic mol-ecules, forming R2(2)(10) and R2(2)(18) motifs, respectively. Descriptors Links Book Title Database Publisher Data Source Authors Aubert,E., Thuaud,F., Ribeiro,N., Desaubry,L., Espinosa,E. Original/Translated Title URL Date of Electronic 20121208 PMCID PMC3588239 Editors
Candidemia by species of the Candida parapsilosis complex in children's hospital: prevalence, biofilm production and antifungal susceptibility	2013	Departamento de Microbiologia, Instituto de Ciencias Biomedicas II, Universidade de Sao Paulo (USP), Sao Paulo, SP, Brazil. lu_ruiz74@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Mycopathologia Periodical, Abbrev. Mycopathologia Pub Date Free Form Apr Volume 175 Issue 4-Mar Start Page 231 Other Pages 239 Notes LR: 20131029; JID: 7505689; 0 (Antifungal Agents); 0 (DNA, Fungal); 0 (DNA, Ribosomal Spacer); 2012/10/05 [received]; 2013/01/15 [accepted]; 2013/02/13 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1573-0832; 0301-486X Accession Number PMID: 23404576 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1007/s11046-013-9616-5 [doi] Output Language Unknown(0) PMID 23404576 Abstract Opportunistic infections are an increasingly common problem in hospitals, and the yeast Candida parapsilosis has emerged as an important nosocomial pathogen. The aims of this study were to determine and compare (i) the prevalence rate among C. parapsilosis complex organisms isolated from blood in a public children's hospital in Sao Paulo state, (ii) the ability of the complex C. parapsilosis species identified to produce biofilm and (iii) the antifungal susceptibility profiles. Forty-nine (49) specimens of isolated blood yeast were analyzed, previously identified as C. parapsilosis by conventional methods. After the molecular analysis, the isolates were characterized as C. parapsilosis sensu stricto (83.7 %), C. orthopsilosis (10.2 %) and C. metapsilosis (6.1 %). All species were able to form biofilm. The species with the highest biofilm production was C. parapsilosis sensu stricto, followed by C. orthopsilosis and further by C. metapsilosis. All of the strains have demonstrated similar susceptibility to fluconazole, caspofungin, voriconazole, cetoconazole and 5-flucytosine. Only one strain of C. parapsilosis was resistant to amphotericin B. Regarding itraconazole, 66.6 and 43.9 % isolates of C. metapsilosis and C. parapsilosis, respectively, have demonstrated to be susceptible dose-dependent, with one isolate of the latter species resistant to the drug. Candida parapsilosis sensu stricto has demonstrated to be the less susceptible, mainly to amphotericin B, caspofungin and "azoles" such as fluconazole. Therefore, C. metapsilosis and C. orthopsilosis are still involved in a restricted number of infections, but these data have become essential for there are very few studies of these species in Latin America. Descriptors Links Book Title Database Publisher Data Source Authors Ruiz,L.S., Khouri,S., Hahn,R.C., da Silva,E.G., de Oliveira,V.K., Gandra,R.F., Paula,C.R. Original/Translated Title URL Date of Electronic 20130213 PMCID Editors
Analysing compliance of cigarette packaging with the FCTC and national legislation in eight former Soviet countries	2013	European Centre on Health of Societies in Transition, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, UK.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Jul Volume 22 Issue 4 Start Page 231 Other Pages 234 Notes JID: 9209612; OTO: NOTNLM; 2012/10/09 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 23047889 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1136/tobaccocontrol-2012-050567 [doi] Output Language Unknown(0) PMID 23047889 Abstract AIM: To analyse compliance of cigarette packets with the Framework Convention on Tobacco Control (FCTC) and national legislation and the policy actions that are required in eight former Soviet Union countries. METHODS: We obtained cigarette packets of each of the 10 most smoked cigarette brands in Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Moldova, Russia and Ukraine. The packets were then analysed using a standardised data collection instrument. The analysis included the placing, size and content of health warning labels and deceptive labels (eg, 'Lights'). Findings were assessed for compliance with the FCTC and national legislation. RESULTS: Health warnings were on all packets from all countries and met the FCTC minimum recommendations on size and position except Azerbaijan and Georgia. All countries used a variety of warnings except Azerbaijan. No country had pictorial health warnings, despite them being mandatory in Georgia and Moldova. All of the countries had deceptive labels despite being banned in all countries except Russia and Azerbaijan where still no such legislation exists. CONCLUSIONS: Despite progress in the use of health warning messages, gaps still remain-particularly with the use of deceptive labels. Stronger surveillance and enforcement mechanisms are required to improve compliance with the FCTC and national legislation. Descriptors Links Book Title Database Publisher Data Source Authors Mir,H., Roberts,B., Richardson,E., Chow,C., McKee,M. Original/Translated Title URL Date of Electronic 20121009 PMCID Editors
Molecular typing of CTX-M-producing escherichia coli isolates from environmental water, swine feces, specimens from healthy humans, and human patients	2013	Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Applied and Environmental Microbiology Periodical, Abbrev. Appl.Environ.Microbiol. Pub Date Free Form Oct Volume 79 Issue 19 Start Page 5988 Other Pages 5996 Notes LR: 20150423; JID: 7605801; 0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (DNA, Bacterial); 0 (Fluoroquinolones); EC 3.5.2.6 (beta-Lactamases); OID: NLM: PMC3811354; 2013/07/26 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1098-5336; 0099-2240 Accession Number PMID: 23892737 Language eng SubFile Journal Article; IM DOI 10.1128/AEM.01740-13 [doi] Output Language Unknown(0) PMID 23892737 Abstract CTX-M-producing Escherichia coli is the predominant type of extended-spectrum beta-lactamase (ESBL)-producing E. coli worldwide. In this study, molecular typing was conducted for 139 CTX-M-producing E. coli isolates, phenotypically positive for ESBLs, isolated from environmental water, swine, healthy humans, and hospitalized patients in Hangzhou, China. The antibiotic resistance profiles of the isolates for the cephalosporins and fluoroquinolones were determined. The isolates showed 100% resistance to cefotaxime and ceftriaxone while maintaining relatively high susceptibility to cefoxitin, cefepime, and ceftazidime. A total of 61.9% (86/139) of the isolates, regardless of origin, showed high resistance to fluoroquinolones. PCRs and DNA sequencing indicated that blaCTX-M-14 was the most prevalent CTX-M-9 group gene and that blaCTX-M-15 and blaCTX-M-55 were the dominant CTX-M-1 group genes. Isolates from all sources with CTX-M types belonging to the CTX-M-1 or CTX-M-9 group were most frequently associated with epidemics. Molecular homology analysis of the isolates, conducted by phylogenetic grouping, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST), demonstrated that the dominant clones belonged to B2-ST131, D-ST648, D-ST38, or A-CC10. These four sequence types (STs) were discovered in E. coli isolates both from humans and from environmental water, suggesting frequent and continuous intercompartment transmission between humans and the aquatic environment. Seven novel sequence types were identified in the current study. In conclusion, this study is the first to report the molecular homology analysis of CTX-M-producing E. coli isolates collected from water, swine, and healthy and hospitalized humans, suggesting that pathogens in the environment might originate both from humans and from animals. Descriptors Links Book Title Database Publisher Data Source Authors Hu,Y.Y., Cai,J.C., Zhou,H.W., Chi,D., Zhang,X.F., Chen,W.L., Zhang,R., Chen,G.X. Original/Translated Title URL Date of Electronic 20130726 PMCID PMC3811354 Editors

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