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Smoking prevalence and cigarette consumption in 187 countries, 1980-2012 2014 Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Institute for Health Metrics and Evaluation, University of Washington, Seattle.; Institute fo
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Journal Article
Periodical, Full
Jama
Periodical, Abbrev.
JAMA
Pub Date Free Form
8-Jan
Volume
311
Issue
2
Start Page
183
Other Pages
192
Notes
LR: 20141120; JID: 7501160; CIN: BMJ. 2014;348:g406. PMID: 24449292; ppublish
Place of Publication
United States
ISSN/ISBN
1538-3598; 0098-7484
Accession Number
PMID: 24399557
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; AIM; IM
DOI
10.1001/jama.2013.284692 [doi]
Output Language
Unknown(0)
PMID
24399557
Abstract
IMPORTANCE: Tobacco is a leading global disease risk factor. Understanding national trends in prevalence and consumption is critical for prioritizing action and evaluating tobacco control progress. OBJECTIVE: To estimate the prevalence of daily smoking by age and sex and the number of cigarettes per smoker per day for 187 countries from 1980 to 2012. DESIGN: Nationally representative sources that measured tobacco use (n = 2102 country-years of data) were systematically identified. Survey data that did not report daily tobacco smoking were adjusted using the average relationship between different definitions. Age-sex-country-year observations (n = 38,315) were synthesized using spatial-temporal gaussian process regression to model prevalence estimates by age, sex, country, and year. Data on consumption of cigarettes were used to generate estimates of cigarettes per smoker per day. MAIN OUTCOMES AND MEASURES: Modeled age-standardized prevalence of daily tobacco smoking by age, sex, country, and year; cigarettes per smoker per day by country and year. RESULTS: Global modeled age-standardized prevalence of daily tobacco smoking in the population older than 15 years decreased from 41.2% (95% uncertainty interval [UI], 40.0%-42.6%) in 1980 to 31.1% (95% UI, 30.2%-32.0%; P
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Database
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Data Source
Authors
Ng,M., Freeman,M.K., Fleming,T.D., Robinson,M., Dwyer-Lindgren,L., Thomson,B., Wollum,A., Sanman,E., Wulf,S., Lopez,A.D., Murray,C.J., Gakidou,E.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Prevalence of common allergies in children and adolescents in Germany: results of the KiGGS study: first follow-up (KiGGS Wave 1) 2014 Abteilung fur Epidemiologie und Gesundheitsmonitoring, Robert Koch-Institut, General Pape Str. 62-66, 12101, Berlin, Deutschland, R.Schmitz@rki.de.
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Print(0)
Ref Type
Journal Article
Periodical, Full
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Periodical, Abbrev.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Pub Date Free Form
Jul
Volume
57
Issue
7
Start Page
771
Other Pages
778
Notes
LR: 20160707; JID: 101181368; ppublish
Place of Publication
Germany
ISSN/ISBN
1437-1588; 1436-9990
Accession Number
PMID: 24950826
Language
ger
SubFile
English Abstract; Journal Article; IM
DOI
10.1007/s00103-014-1975-7 [doi]
Output Language
Unknown(0)
PMID
24950826
Abstract
The first follow-up of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 1) was conducted from 2009 to 2012 as a combined cross-sectional and longitudinal study and provides, among other things, data on allergic diseases. Data collection was carried out by telephone interviews. In total, 6,093 girls and 6,275 boys were included, among them 4,455 newly recruited 0- to 6-year-olds (response 38.8%) and 7,913 KiGGS follow-up participants aged 7-17 years (response 72.9%). Based on parent reports, 15.6% (95% confidence interval 14.7-16.5) of children and adolescents aged 0-17 years were currently affected by at least one atopic disease. The 12-month prevalence rates of hay fever, atopic dermatitis, and asthma were 9.1% (8.4-9.8), 6.0% (5.4-6.6), and 4.1% (3.6-4.6), respectively. In all, 2.2% (1.9-2.6) of the children and adolescents were currently suffering from contact dermatitis. Compared with the baseline KiGGS survey from 2003 to 2006, a higher percentage of participants reported the occurrence of asthma within the past 12 months in the recent KiGGS Wave 1 (4.1 vs. 3.2%; p = 0.0034). The total increase is mainly due to higher prevalence rates among 0- to 6-year-olds, especially in girls. Higher 12-month prevalence rates can be also observed for hay fever among 0- to 6-year-olds, especially in girls, although the total increase is not statistically significant (9.1 vs. 8.3%; p = 0.08). There was a declining trend for atopic dermatitis: 6.8% (2003-2006) vs. 5.4% (2009-2012); p = 0.0015.
Descriptors
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Database
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Data Source
Authors
Schmitz,R., Thamm,M., Ellert,U., Kalcklosch,M., Schlaud,M., KiGGS Study Group
Original/Translated Title
Verbreitung haufiger Allergien bei Kindern und Jugendlichen in Deutschland : Ergebnisse der KiGGS-Studie - Erste Folgebefragung (KiGGS Welle 1)
URL
Date of Electronic
PMCID
Editors
Epidemiology of gastroesophageal reflux disease 2014 Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI, USA; Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: jhr@umich.edu.; Division of Gastroenterology, University of Michigan
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Gastroenterology clinics of North America
Periodical, Abbrev.
Gastroenterol.Clin.North Am.
Pub Date Free Form
Mar
Volume
43
Issue
1
Start Page
1
Other Pages
14
Notes
CI: Published by Elsevier Inc.; JID: 8706257; Adenocarcinoma Of Esophagus; OTO: NOTNLM; 2013/12/27 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1558-1942; 0889-8553
Accession Number
PMID: 24503355
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.1016/j.gtc.2013.11.006 [doi]
Output Language
Unknown(0)
PMID
24503355
Abstract
The prevalence of gastroesophageal reflux disease (GERD) symptoms increased approximately 50% until the mid-1990s, when it plateaued. The incidence of complications related to GERD including hospitalization, esophageal strictures, esophageal adenocarcinoma, and mortality also increased during that time period, but the increase in esophageal adenocarcinoma has since slowed, and the incidence of strictures has decreased since the mid-1990s. GERD is responsible for the greatest direct costs in the United States of any gastrointestinal disease, and most of those expenditures are for pharmacotherapy. Risk factors for GERD include obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases.
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Database
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Data Source
Authors
Rubenstein,J.H., Chen,J.W.
Original/Translated Title
URL
Date of Electronic
20131227
PMCID
Editors
Risk factors associated with Barrett's epithelial dysplasia 2014 Mikiko Fujita, Yuri Nakamura, Saeko Kasashima, Maiko Furukawa, Ryoichi Misaka, Hikaru Nagahara, Department of Gastroenterology, Aoyama Hospital, Tokyo Women's Medical University, Tokyo 1070061, Japan.; Mikiko Fujita, Yuri Nakamura, Saeko Kasashima, Maiko
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
World journal of gastroenterology
Periodical, Abbrev.
World J.Gastroenterol.
Pub Date Free Form
21-Apr
Volume
20
Issue
15
Start Page
4353
Other Pages
4361
Notes
LR: 20151022; JID: 100883448; 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); OID: NLM: PMC3989971; OTO: NOTNLM; 2013/09/05 [received]; 2013/10/27 [revised]; 2013/11/18 [accepted]; ppublish
Place of Publication
China
ISSN/ISBN
2219-2840; 1007-9327
Accession Number
PMID: 24764673
Language
eng
SubFile
Journal Article; IM
DOI
10.3748/wjg.v20.i15.4353 [doi]
Output Language
Unknown(0)
PMID
24764673
Abstract
AIM: To elucidate risk factors associated with dysplasia of short-segment Barrett's esophagus (BE). METHODS: A total of 151 BE patients who underwent endoscopic examination from 2004 to 2008 in Aoyama Hospital, Tokyo Women's Medical University, Japan and whose diagnosis was confirmed from biopsy specimens were enrolled in the study. BE was diagnosed based on endoscopic findings of gastric-appearing mucosa or apparent columnar-lined esophagus proximal to the esophagogastric junction. Dysplasia was classified into three grades - mild, moderate and severe - according to the guidelines of the Vienna Classification System for gastrointestinal epithelial neoplasia. Anthropometric and biochemical data were analyzed to identify risk factors for BE dysplasia. The prevalence of Helicobacter pylori (H. pylori) infection and the expression of p53 by immunohistological staining were also investigated. RESULTS: Histological examination classified patients into three types: specialized columnar epithelium (SCE) (n = 65); junctional (n = 38); and gastric fundic (n = 48). The incidence of dysplasia or adenocarcinoma from BE of the SCE type was significantly higher than that of the other two types (P
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Book Title
Database
Publisher
Data Source
Authors
Fujita,M., Nakamura,Y., Kasashima,S., Furukawa,M., Misaka,R., Nagahara,H.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC3989971
Editors
Effect of glycemic control on self-perceived oral health, periodontal parameters, and alveolar bone loss among patients with prediabetes 2014 Eng. A.B. Research Chair for Growth Factors and Bone Regeneration, Three-Dimensional Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of periodontology
Periodical, Abbrev.
J.Periodontol.
Pub Date Free Form
Feb
Volume
85
Issue
2
Start Page
234
Other Pages
241
Notes
JID: 8000345; 0 (Blood Glucose); 0 (Hemoglobin A, Glycosylated); 2013/05/09 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1943-3670; 0022-3492
Accession Number
PMID: 23659422
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; D; IM
DOI
10.1902/jop.2013.130008 [doi]
Output Language
Unknown(0)
PMID
23659422
Abstract
BACKGROUND: The effect of glycemic control on severity of periodontal inflammatory parameters in patients with prediabetes is unknown. The aim of the present study is to assess the effects of glycemic control on self-perceived oral health, periodontal parameters, and marginal bone loss (MBL) in patients with prediabetes. METHODS: A total of 303 individuals were included. Hemoglobin A1c (HbA1c) and fasting blood glucose levels (FBGLs) were recorded. Participants were divided into three groups: 1) group A: 75 patients with prediabetes (FBGLs = 100 to 125 mg/dL [HbA1c >/=5%]); 2) group B: 78 individuals previously considered prediabetic but having FBGLs
Descriptors
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Database
Publisher
Data Source
Authors
Javed,F., Thafeed Alghamdi,A.S., Mikami,T., Mehmood,A., Ahmed,H.B., Samaranayake,L.P., Tenenbaum,H.C.
Original/Translated Title
URL
Date of Electronic
20130509
PMCID
Editors
9-(3-Bromo-5-chloro-2-hy-droxy-phen-yl)-10-(2-hy-droxy-eth-yl)-3,6-diphenyl-3,4,9 ,10-tetra-hydro-acridine-1,8(2H,5H)-dione 2014 Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Turkey.; Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 5GD, England ; Chemistry Department, Faculty of Science, Minia University, 6151
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Print(0)
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Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
17-May
Volume
70
Issue
Pt 6
Start Page
o663
Other Pages
4
Notes
LR: 20140620; JID: 101089178; OID: NLM: PMC4051074; 2014/06/01 [ecollection]; 2014/05/07 [received]; 2014/05/08 [accepted]; 2014/05/17 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 24940246
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536814010460 [doi]
Output Language
Unknown(0)
PMID
24940246
Abstract
In the title compound, C33H27BrClNO4, the di-hydro-pyridine ring adopts a flattened boat conformation. The mol-ecular conformation is stabilized by an intra-molecular O-Hcdots, three dots, centeredO hydrogen bond, with an S(8) ring motif. In the crystal, O-Hcdots, three dots, centeredO, C-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredCl hydrogen bonds, and C-Hcdots, three dots, centeredpi inter-actions link the mol-ecules, forming a three-dimensional network. In the acridinedione ring system, the two ring C atoms at the 2- and 3-positions, and the C atom at the 6-position and the atoms of the phenyl ring attached to the C atom at the 6-position are disordered over two sets of sites with occupancy ratios of 0.783 (5):0.217 (5) and 0.526 (18):0.474 (18), respectively.
Descriptors
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Database
Publisher
Data Source
Authors
Akkurt,M., Mohamed,S.K., Abdelhamid,A.A., Gaber,A.A., Albayati,M.R.
Original/Translated Title
URL
Date of Electronic
20140517
PMCID
PMC4051074
Editors
The electronic cigarette: the new cigarette of the 21st century? 2014 School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Sch
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Print(0)
Ref Type
Journal Article
Periodical, Full
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Periodical, Abbrev.
J.Bras.Pneumol.
Pub Date Free Form
Oct
Volume
40
Issue
5
Start Page
564
Other Pages
572
Notes
LR: 20151119; JID: 101222274; 6M3C89ZY6R (Nicotine); OID: NLM: PMC4263338; 2014/01/13 [received]; 2014/06/27 [accepted]; ppublish
Place of Publication
Brazil
ISSN/ISBN
1806-3756; 1806-3713
Accession Number
PMID: 25410845
Language
eng; por
SubFile
Journal Article; Review; IM
DOI
S1806-37132014000500564 [pii]
Output Language
Unknown(0)
PMID
25410845
Abstract
The electronic nicotine delivery system, also known as the electronic cigarette, is generating considerable controversy, not only in the general population but also among health professionals. Smokers the world over have been increasingly using electronic cigarettes as an aid to smoking cessation and as a substitute for conventional cigarettes. There are few available data regarding the safety of electronic cigarettes. There is as yet no evidence that electronic cigarettes are effective in treating nicotine addiction. Some smokers have reported using electronic cigarettes for over a year, often combined with conventional cigarettes, thus prolonging nicotine addiction. In addition, the increasing use of electronic cigarettes by adolescents is a cause for concern. The objective of this study was to describe electronic cigarettes and their components, as well as to review the literature regarding their safety; their impact on smoking initiation and smoking cessation; and regulatory issues related to their use.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Knorst,M.M., Benedetto,I.G., Hoffmeister,M.C., Gazzana,M.B.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4263338
Editors
Diagnosis and treatment of gastroesophageal reflux disease 2014 Raul Badillo, Dawn Francis, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL 32224, United States.; Raul Badillo, Dawn Francis, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL 32224, Uni
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
World journal of gastrointestinal pharmacology and therapeutics
Periodical, Abbrev.
World J.Gastrointest.Pharmacol.Ther.
Pub Date Free Form
6-Aug
Volume
5
Issue
3
Start Page
105
Other Pages
112
Notes
LR: 20140820; JID: 101547456; OID: NLM: PMC4133436; OTO: NOTNLM; 2014/01/24 [received]; 2014/06/10 [revised]; 2014/06/20 [accepted]; ppublish
Place of Publication
United States
ISSN/ISBN
2150-5349; 2150-5349
Accession Number
PMID: 25133039
Language
eng
SubFile
Journal Article; Review
DOI
10.4292/wjgpt.v5.i3.105 [doi]
Output Language
Unknown(0)
PMID
25133039
Abstract
Gastroesophageal reflux disease (GERD) is a common disease with a prevalence as high as 10%-20% in the western world. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. Those with the highest specificity for GERD are acid regurgitation and heartburn. In the absence of alarm symptoms, these symptoms can allow one to make a presumptive diagnosis and initiate empiric therapy. In certain situations, further diagnostic testing is needed to confirm the diagnosis as well as to assess for complications or alternate causes for the symptoms. GERD complications include erosive esophagitis, peptic stricture, Barrett's esophagus, esophageal adenocarcinoma and pulmonary disease. Management of GERD may involve lifestyle modification, medical therapy and surgical therapy. Lifestyle modifications including weight loss and/or head of bed elevation have been shown to improve esophageal pH and/or GERD symptoms. Medical therapy involves acid suppression which can be achieved with antacids, histamine-receptor antagonists or proton-pump inhibitors. Whereas most patients can be effectively managed with medical therapy, others may go on to require anti-reflux surgery after undergoing a proper pre-operative evaluation. The purpose of this review is to discuss the current approach to the diagnosis and treatment of gastroesophageal reflux disease.
Descriptors
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Book Title
Database
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Data Source
Authors
Badillo,R., Francis,D.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4133436
Editors
Tobacco cessation among low-income smokers: motivational enhancement and nicotine patch treatment 2014 Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI;
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Apr
Volume
16
Issue
4
Start Page
413
Other Pages
422
Notes
LR: 20151119; GR: K01 CA160670/CA/NCI NIH HHS/United States; GR: R01DA010860/DA/NIDA NIH HHS/United States; JID: 9815751; 6M3C89ZY6R (Nicotine); OID: NLM: PMC3954421; 2013/10/30 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 24174612
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; IM
DOI
10.1093/ntr/ntt166 [doi]
Output Language
Unknown(0)
PMID
24174612
Abstract
INTRODUCTION: Despite decades of tobacco use decline among the general population in the United States, tobacco use among low-income populations continues to be a major public health concern. Smoking rates are higher among individuals with less than a high school education, those with no health insurance, and among individuals living below the federal poverty level. Despite these disparities, smoking cessation treatments for low-income populations have not been extensively tested. In the current study, the efficacy of 2 adjunctive smoking cessation interventions was evaluated among low-income smokers who were seen in a primary care setting. METHODS: A total of 846 participants were randomly assigned either to motivational enhancement treatment plus brief physician advice and 8 weeks of nicotine replacement therapy (NRT) or to standard care, which consisted of brief physician advice and 8 weeks of NRT. Tobacco smoking abstinence was at 1, 2, 6, and 12 months following baseline. RESULTS: The use of the nicotine patch, telephone counseling, and positive decisional balance were predictive of increased abstinence rates, and elevated stress levels and temptation to smoke in both social/habit and negative affect situations decreased abstinence rates across time. Analyses showed intervention effects on smoking temptations, length of patch use, and number of telephone contacts. Direct intervention effects on abstinence rates were not significant, after adjusting for model predictors and selection bias due to perirandomization attrition. CONCLUSIONS: Integrating therapeutic approaches that promote use of and adherence to medications for quitting smoking and that target stress management and reducing negative affect may enhance smoking cessation among low-income smokers.
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Database
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Data Source
Authors
Bock,B.C., Papandonatos,G.D., de Dios,M.A., Abrams,D.B., Azam,M.M., Fagan,M., Sweeney,P.J., Stein,M.D., Niaura,R.
Original/Translated Title
URL
Date of Electronic
20131030
PMCID
PMC3954421
Editors
Assessing fishing and marine biodiversity changes using fishers' perceptions: the Spanish Mediterranean and Gulf of Cadiz case study 2014 Institut de Ciencies del Mar (ICM-CSIC). Barcelona, Spain ; UMR EME 212 Centre de Recherche Halieutique Mediterraneenne et Tropicale. IRD - IFREMER & Universite Montpellier II. Sete Cedex, France.; OCEANA, Madrid, Spain.; Investigacion, Planificacion y De
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
PloS one
Periodical, Abbrev.
PLoS One
Pub Date Free Form
22-Jan
Volume
9
Issue
1
Start Page
e85670
Other Pages
Notes
LR: 20151119; JID: 101285081; OID: NLM: PMC3899065; 2014 [ecollection]; 2013/05/21 [received]; 2013/11/30 [accepted]; 2014/01/22 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1932-6203; 1932-6203
Accession Number
PMID: 24465644
Language
eng
SubFile
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; IM
DOI
10.1371/journal.pone.0085670 [doi]
Output Language
Unknown(0)
PMID
24465644
Abstract
BACKGROUND: The expansion of fishing activities has intensively transformed marine ecosystems worldwide. However, available time series do not frequently cover historical periods. METHODOLOGY: Fishers' perceptions were used to complement data and characterise changes in fishing activity and exploited ecosystems in the Spanish Mediterranean Sea and Gulf of Cadiz. Fishers' interviews were conducted in 27 fishing harbours of the area, and included 64 fishers from ages between 20 to >70 years old to capture the experiences and memories of various generations. Results are discussed in comparison with available independent information using stock assessments and international convention lists. PRINCIPAL FINDINGS: According to fishers, fishing activity substantially evolved in the area with time, expanding towards deeper grounds and towards areas more distant from the coast. The maximum amount of catch ever caught and the weight of the largest species ever captured inversely declined with time. Fishers (70%) cited specific fishing grounds where depletion occurred. They documented ecological changes of marine biodiversity during the last half of the century: 94% reported the decline of commercially important fish and invertebrates and 61% listed species that could have been extirpated, with frequent mentions to cartilaginous fish. Declines and extirpations were in line with available quantitative evaluations from stock assessments and international conventions, and were likely linked to fishing impacts. Conversely, half of interviewed fishers claimed that several species had proliferated, such as cephalopods, jellyfish, and small-sized fish. These changes were likely related to trophic cascades due to fishing and due to climate change effects. The species composition of depletions, local extinctions and proliferations showed differences by region suggesting that regional dynamics are important when analysing biodiversity changes. CONCLUSIONS/SIGNIFICANCE: Using fishers' perceptions, fishing and ecological changes in the study area were documented. The recovery of local ecological knowledge provides valuable information complementing quantitative monitoring and evaluation surveys.
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Data Source
Authors
Coll,M., Carreras,M., Ciercoles,C., Cornax,M.J., Gorelli,G., Morote,E., Saez,R.
Original/Translated Title
URL
Date of Electronic
20140122
PMCID
PMC3899065
Editors