WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence	2009	Department of Digestive Tract Diseases, Medical University of Lodz. anna.mokrowiecka@umed.lodz.pl	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Periodical, Abbrev. Pol.Merkur Lekarski Pub Date Free Form May Volume 26 Issue 155 Start Page 385 Other Pages 389 Notes LR: 20151119; JID: 9705469; 0 (Biomarkers, Tumor); ppublish Place of Publication Poland ISSN/ISBN 1426-9686; 1426-9686 Accession Number PMID: 19606680 Language pol SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 19606680 Abstract The incidence of esophageal adenocarcinoma (ADC) has been increasing rapidly over the past few decades. Gastro-esopageal reflux disease (GERD), Barrett's esophagus (BE) and Barrett-associated dysplasia are a risk factor for esophageal cancer, but endoscopic surveillance have only a limited influence on cancer mortality. There is a great need to find molecular biomarkers predicting increased progression risk in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence to improve risk assessment and stratification of patients to surveillance program. AIM OF THE STUDY: To evaluate the polymorphism and prevalence of loss of heterozygosity (LOH) of APC tumor suppressor gene in mataplasia, dysplasia and adenocarcinoma. MATERIAL AND METHODS: In esophageal mucosal samples of 79 patients with: GERD (n=33), BE (n=27), BE+dysplasia (n=8) and ADC (n=11) we have studied LOH of APC tumor suppressor gene using PCR-restriction fragment length polymorphism (RFLP). A 133 bp fragment, spanning exon 11 of the APC gene was amplified, and Rsal digestion of the PCR product defined the alleles as either homozygous 133 bp (Rsa(-/-)) or 87 and 46 bp (Rsa(+/+)) fragments, and heterozygous (Rsa(+/-)) exhibiting the three fragments. Control peripheral blood cell DNA samples have been collected from 60 normal healthy subjects. RESULTS: Among 79 patients, there were 16 heterozygous (20%) for APC gene. In 16 informative heterozygous LOH was detected in 7 cases: 2/5 with GERD, 3/7--with BE, 1/2--with BE+dysplasia and 1/2--with ADC. There were no statistical differences between studied groups (NS). Distribution of the three alleles, Rsa(+/-), Rsa(+/+), and Rsa(-/-) was: 38, 47 and 15% in the healthy individuals, 25%, 25% and 50%--in GERD patients, 29%, 41% and 29%--in BE, 36%, 45% and 18% in BE+dysplasia and 25%, 67% and 8% in ADC patients, respectively. The frequency of heterozygous cases in control group was significantly higher than in patients group (p = 0.018), whereas Rsa (-/-) were the most frequent in patients group (p = 0.008). Rsa (-/-) were seen significantly more often in GERD compared to ADC patients (p = 0.005), in opposite to Rsa (+/+), which were significantly more frequent in ADC vs. GERD (p = 0.007). CONCLUSIONS: APC gene inactivation concerns minority of patients with esophageal adenocarcinoma, however, its detection indicates higher risk of progression to ADC. APC alternations appear to be early in GERD-BE-dysplasia-ADC sequence. The specific polymorphism may identify patients with high risk of progression into BE. Descriptors Adenocarcinoma/genetics/pathology, Adult, Aged, Barrett Esophagus/genetics/pathology, Biomarkers, Tumor/analysis, Disease Progression, Esophageal Neoplasms/genetics/pathology, Esophagus/pathology, Female, Gastric Mucosa/pathology, Gastroesophageal Reflux/genetics/pathology, Genes, APC, Heterozygote, Humans, Hyperplasia, Loss of Heterozygosity/genetics, Male, Metaplasia, Middle Aged, Polymorphism, Genetic, Precancerous Conditions/genetics Links Book Title Database Publisher Data Source Authors Mokrowiecka,A., Wierzchniewska-Lawska,A., Smolarz,B., Romanowicz-Makowska,H., Malecka-Panas,E. Original/Translated Title Polimorfizm/utrata heterozygotycznosci genu APC w sekwencji GERD-przelyk barretta-dysplazja-rak gruczolowy przelyku URL Date of Electronic PMCID Editors
Comparison of smoking behaviour among medical and other college students in Rawalpindi	2009	Department of Community Medicine, Foundation University Medical College, Rawalpindi. babarmumtaz41@gmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Periodical, Abbrev. J.Coll.Physicians Surg.Pak. Pub Date Free Form Jan Volume 19 Issue 1 Start Page 7 Other Pages 10 Notes LR: 20151119; JID: 9606447; 2007/08/21 [received]; 2008/11/24 [accepted]; ppublish Place of Publication Pakistan ISSN/ISBN 1022-386X; 1022-386X Accession Number PMID: 19149972 Language eng SubFile Comparative Study; Journal Article; IM DOI 01.2009/JCPSP.710 [doi] Output Language Unknown(0) PMID 19149972 Abstract OBJECTIVE: To assess the frequency of smoking among students in medical and non-medical colleges of Rawalpindi and to explore the differences in smoking behaviour of the two college students. STUDY DESIGN: A cross-sectional comparative study. PLACE AND DURATION OF STUDY: Random sampling of students from a medical college and non-medical college of Rawalpindi was carried out in October 2006. METHODOLOGY: An anonymous, self-administered questionnaire was used for the study which inquired about gender, number of daily smoked cigarettes, feeling addicted, attempt and success or failure at quitting, most important factor that helped in quitting smoking and reasons of smoking were compared between the medical college and non-medical college students. RESULTS: The total medical college students in the study were 444 and among them 32.7% were smokers. The total nonmedical college students were 405 and among them 41% were smokers (p=0.012). Nine point seven percent medical students and only 6% non-medical students were successful in quitting their habit of smoking (p=0.231). CONCLUSION: There was significant difference in smoking behaviour among the group. Being medical students it had effect on the decision to smoke, which may have modified their consumption level. Descriptors Adult, Attitude to Health, Cross-Sectional Studies, Female, Health Behavior, Humans, Male, Pakistan/epidemiology, Smoking/epidemiology/psychology, Students/psychology/statistics & numerical data, Students, Medical/psychology/statistics & numerical data, Surveys and Questionnaires, Universities, Young Adult Links Book Title Database Publisher Data Source Authors Mumtaz,B., Chaudhary,I. A., Arshad,M., Samiullah Original/Translated Title URL Date of Electronic PMCID Editors
A reliable analytical approach based on gas chromatography coupled to triple quadrupole and time-of-flight mass analyzers for the determination and confirmation of polycyclic aromatic hydrocarbons in complex matrices from aquaculture activities	2009	Research Institute for Pesticides and Water (IUPA), Avda Sos Baynat, s/n. University Jaume I, 12071 Castellon, Spain.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Rapid communications in mass spectrometry : RCM Periodical, Abbrev. Rapid Commun.Mass Spectrom. Pub Date Free Form Jul Volume 23 Issue 13 Start Page 2075 Other Pages 2086 Notes CI: Copyright (c) 2009; JID: 8802365; 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Water Pollutants, Chemical); ppublish Place of Publication England ISSN/ISBN 1097-0231; 0951-4198 Accession Number PMID: 19504494 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1002/rcm.4120 [doi] Output Language Unknown(0) PMID 19504494 Abstract The potential of gas chromatography coupled to tandem mass spectrometry (GC/MS/MS) with a triple quadrupole analyzer (QqQ) has been investigated for the quantification and reliable identification of sixteen polycyclic aromatic hydrocarbons (PAHs) from the EPA priority list in animal and vegetable samples from aquaculture activities, whose fat content ranged from 5 to 100%. Matrices analyzed included fish fillet, fish feed, fish oil and linseed oil. Combining optimized saponification and solid-phase extraction led to high efficiency in the elimination of interfering compounds, mainly fat, from the extracts. The developed procedure minimized the presence of these interfering compounds in the extracts and provided satisfactory recoveries of PAHs. The excellent sensitivity and selectivity of GC/(QqQ)MS/MS in selected reaction monitoring (SRM) allowed to reach limits of detection at pg/g levels. Two SRM transitions were acquired for each analyte to ensure reliable identification of compounds detected in samples. Confirmation of positive findings was performed by GC coupled to high-resolution time-of-flight mass spectrometry (GC/TOFMS). The accurate mass information provided by GC/TOFMS in full acquisition mode together with its high mass resolution makes it a powerful analytical tool for the unequivocal confirmation of PAHs in the matrices tested. The method developed was applied to the analysis of real-world samples of each matrix studied with the result of detecting and confirming the majority of analytes at the microg/kg level by both QqQ and TOF mass spectrometers. Descriptors Animals, Fish Products/analysis, Fishes, Gas Chromatography-Mass Spectrometry/instrumentation/methods, Meat/analysis, Polycyclic Hydrocarbons, Aromatic/analysis, Tandem Mass Spectrometry/instrumentation/methods, Water Pollutants, Chemical/analysis Links Book Title Database Publisher John Wiley & Sons, Ltd Data Source Authors Nacher-Mestre,J., Serrano,R., Portoles-Nicolau,T., Hernandez,F., Benedito-Palos,L., Perez-Sanchez,J. Original/Translated Title URL Date of Electronic PMCID Editors
Variable bacterial load of Legionella spp. in a hospital water system	2009	Department of Biomedical Science - Hygiene Section, University of Bari, Bari, Italy. c.napoli@igiene.uniba.it	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Science of the total environment Periodical, Abbrev. Sci.Total Environ. Pub Date Free Form 20-Dec Volume 408 Issue 2 Start Page 242 Other Pages 244 Notes JID: 0330500; 2009/08/04 [received]; 2009/09/16 [revised]; 2009/09/24 [accepted]; ppublish Place of Publication Netherlands ISSN/ISBN 1879-1026; 0048-9697 Accession Number PMID: 19836825 Language eng SubFile Journal Article; IM DOI 10.1016/j.scitotenv.2009.09.039 [doi] Output Language Unknown(0) PMID 19836825 Abstract Several approved protocols for the prevention of Legionella pneumonia base the type of intervention (to disinfect or not) on the level of contamination found (cfu/L). However, if the level of contamination by Legionella spp. of a water system fluctuates in a short period of time, inadequate sampling could lead to different decisions being made. To determine if there are significant variations in the bacterial count of Legionella spp., water samples were taken at different times from the same sites. Eight wards were selected from a large hospital in Southern Italy and a water sample was taken from 21 taps in each ward at the same time each day for 5 consecutive days. A Freidman test detected statistically significant differences in average Legionella spp. load over the 5 sampling days (p value10,000 cfu/L in hospitals without documented cases of disease. In the present study, the daily average loads varied, during the 5-day sampling period, above and below this cut-off (10,000 cfu/L). This means that the decision to disinfect or not would be different depending on which day the sampling was carried out. Our data suggest that, especially in health-care facilities, a single sampling would not give a realistic estimation of risk; therefore, even at lower levels of bacterial load, measures should be taken to reduce it further. Descriptors Colony Count, Microbial, Hospitals, Italy, Legionella pneumophila/growth & development, Legionnaires' Disease/microbiology/prevention & control, Statistics, Nonparametric, Water Microbiology Links Book Title Database Publisher Data Source Authors Napoli,C., Iatta,R., Fasano,F., Marsico,T., Montagna,M. T. Original/Translated Title URL Date of Electronic PMCID Editors
Impact of the Spanish smoking law on exposure to secondhand smoke in offices and hospitality venues: before-and-after study	2009	Public Health Agency, Barcelona, Spain. mnebot@aspb.es	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Environmental health perspectives Periodical, Abbrev. Environ.Health Perspect. Pub Date Free Form Mar Volume 117 Issue 3 Start Page 344 Other Pages 347 Notes LR: 20141210; JID: 0330411; 0 (Tobacco Smoke Pollution); OID: NLM: PMC2661901; OTO: NOTNLM; 2008/06/23 [received]; 2008/09/19 [accepted]; 2008/09/19 [epublish]; ppublish Place of Publication United States ISSN/ISBN 1552-9924; 0091-6765 Accession Number PMID: 19337506 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1289/ehp.11845 [doi] Output Language Unknown(0) PMID 19337506 Abstract BACKGROUND/OBJECTIVES: A smoking law was passed by the Spanish Parliament in December 2005 and was enforced by 1 January 2006. The law bans smoking in all indoor workplaces but only in some hospitality venues, because owners are allowed to establish a smoking zone (venues>100 m2) or to allow smoking without restrictions (venues<100 m2). The objective of the study is to assess the impact of the Spanish smoking law on exposure to secondhand smoke (SHS) in enclosed workplaces, including hospitality venues. MATERIALS AND METHODS: The study design is a before-and-after evaluation. We studied workplaces and hospitality venues from eight different regions of Spain. We took repeated samples of vapor-phase nicotine concentration in 398 premises, including private offices (162), public administration offices (90), university premises (43), bars and restaurants (79), and discotheques and pubs (24). RESULTS: In the follow-up period, SHS levels were markedly reduced in indoor offices. The median decrease in nicotine concentration ranged from 60.0% in public premises to 97.4% in private areas. Nicotine concentrations were also markedly reduced in bars and restaurants that became smoke-free (96.7%) and in the no-smoking zones of venues with separate spaces for smokers (88.9%). We found no significant changes in smoking zones or in premises allowing smoking, including discotheques and pubs. CONCLUSIONS: Overall, this study shows the positive impact of the law on reducing SHS in indoor workplaces. However, SHS was substantially reduced only in bars and restaurants that became smoke-free. Most hospitality workers continue to be exposed to very high levels of SHS. Therefore, a 100% smoke-free policy for all hospitality venues is required. Descriptors Humans, Inhalation Exposure/adverse effects/statistics & numerical data, Occupational Exposure/adverse effects/statistics & numerical data, Restaurants, Smoking/legislation & jurisprudence, Spain, Tobacco Smoke Pollution/adverse effects/statistics & numerical data, Workplace, evaluation, hospitality sector, secondhand smoke, smoking law, workplaces Links Book Title Database Publisher Data Source Authors Nebot,M., Lopez,M. J., Ariza,C., Perez-Rios,M., Fu,M., Schiaffino,A., Munoz,G., Salto,E., Fernandez,E., Spanish Smoking Law Evaluation Group Original/Translated Title URL Date of Electronic 20080919 PMCID PMC2661901 Editors
Prevalence and determinants of physical activity and lifestyle in relation to obesity among schoolchildren in Israel	2009		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Public Health Nutr Periodical, Abbrev. Public Health Nutr. Pub Date Free Form Volume 12 Issue 6 Start Page 774 Other Pages 82 Notes ID: 18674392 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract OBJECTIVE: To describe the relationships between physical activity, lifestyle determinants and obesity in adolescent Israeli schoolchildren.Design and settingCross-sectional survey. SUBJECTS: The MABAT Youth Survey was a nationally representative, school-based study of youth in grades 7 to 12 (ages 11-19 years). METHODS: Self-administered questionnaires assessed health behaviours and anthropometric indices were measured. Logistic regression analysis was used to examine the associations between obesity, physical activity, socio-economic status and other lifestyle habits. One-way ANOVA was used to determine mean physical activity levels (MET values) by BMI categories. RESULTS: The prevalence of overweight was 13-15 % and of obesity 4-9 % depending on gender and ethnicity, and was higher among the non-Jewish sectors. Thirty-six per cent and 57 % of Jewish girls and boys, and 40 % and 58 % of non-Jewish girls and boys, respectively, were optimally active. Boys from low socio-economic schools and those who slept for less than 6 h at night were less active. Girls from middle school were found to be 53 % more optimally physically active among Jews, and 89 % more among non-Jews, compared with girls from high school (P = 0.001); girls with less educated parents were also less physically active. No clear relationship was found between the level of obesity and physical activity. CONCLUSIONS: Physical inactivity was strongly related to gender, age, social status, sleeping habits, hookah smoking, and parental educational status. Education and intervention programmes should focus on these risk factors. Descriptors Body Mass Index, Exercise/physiology, Life Style, Obesity/epidemiology, Overweight/epidemiology, Adolescent, Analysis of Variance, Anthropometry, Arabs, Child, Cross-Sectional Studies, Educational Status, Female, Health Behavior, Humans, Israel/epidemiology, Jews, Logistic Models, Male, Obesity/ethnology, Obesity/etiology, Odds Ratio, Overweight/ethnology, Overweight/etiology, Prevalence, Risk Factors, Sleep/physiology, Socioeconomic Factors, Questionnaires, Young Adult Links http://dx.doi.org/10.1017/S1368980008002991 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Nitzan Kaluski,Dorit, Demem Mazengia,Getachew, Shimony,Tal, Goldsmith,Rebecca, Berry,Elliot M. Original/Translated Title URL Date of Electronic PMCID Editors
New tobacco trends: waterpipe (hookah) smoking and implications for healthcare providers	2009		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full J Am Acad Nurse Pract Periodical, Abbrev. J.Am.Acad.Nurse Pract. Pub Date Free Form Volume 21 Issue 5 Start Page 258 Other Pages 60 Notes ID: 19432909 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract PURPOSE: To inform healthcare providers about waterpipe smoking, a new trend in tobacco use that is gaining popularity among adolescents and young adults. DATA SOURCES: American Lung Association Tobacco Policy Alert on Waterpipe Smoking, World Health Organization Tobacco Regulation Advisory Note on Waterpipe Smoking, and pertinent publications available in the literature. CONCLUSIONS: Waterpipe smoking is a new trend in tobacco use that is associated with multiple health problems, including addiction. Healthcare providers should be aware of new tobacco trends that may affect patients, such as waterpipe smoking, that are potential gateways to nicotine addiction. IMPLICATIONS FOR PRACTICE: Tobacco comes in many forms, all of which are addicting. Healthcare providers must be knowledgeable about new forms of tobacco to address all types of tobacco use with patients. Healthcare providers also have a responsibility to educate patients about the health risks inherent in these products to help prevent the long-lasting problem of nicotine addiction. Descriptors Smoking, Tobacco Use Disorder, Adolescent, Attitude to Health, Health Education, Humans, Professional Role, Smoking/adverse effects, Smoking/prevention & control, Smoking/trends, Tobacco Use Disorder/complications, Tobacco Use Disorder/epidemiology, Tobacco Use Disorder/prevention & control, United States/epidemiology, Water, Young Adult Links http://dx.doi.org/10.1111/j.1745-7599.2009.00402.x Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Noonan,Devon, Kulbok,Pamela A. Original/Translated Title URL Date of Electronic PMCID Editors
Pharmacophore modeling and virtual screening studies of checkpoint kinase 1 inhibitors	2009	State Key Laboratory of Biotherapy, West China Hospital, West China School of Pharmacy, Sichuan University.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Chemical & pharmaceutical bulletin Periodical, Abbrev. Chem.Pharm.Bull.(Tokyo) Pub Date Free Form Jul Volume 57 Issue 7 Start Page 704 Other Pages 709 Notes LR: 20111102; JID: 0377775; 0 (Enzyme Inhibitors); EC 2.7.- (Protein Kinases); EC 2.7.11.1 (Checkpoint kinase 1); ppublish Place of Publication Japan ISSN/ISBN 0009-2363; 0009-2363 Accession Number PMID: 19571415 Language eng SubFile Journal Article; IM DOI JST.JSTAGE/cpb/57.704 [pii] Output Language Unknown(0) PMID 19571415 Abstract In this study, chemical feature-based 3-dimensional (3D) pharmacophore models of Checkpoint kinase 1 (Chk1) inhibitors were developed based on the known inhibitors of Chk1. The best pharmacophore model Hypo1 was characterized by the best correlation coefficient (0.9577), and the lowest root mean square deviation (0.8871). Hypo1 consists of one hydrogen-bond acceptor, one hydrogen-bond donor, and two hydrophobic features, as well as one excluded volume. This pharmacophore model was further validated by both test set and cross validation methods. A comparison analysis of Hypo1 with chemical features in the active site of Chk1 indicates that the pharmacophore model Hypo1 can correctly reflect the interactions between Chk1 and its ligands. Then Hypo1 was used to screen chemical databases, including Specs and Chinese Nature Product Database (CNPD) for potential lead compounds. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking study to refine the retrieved hits. Finally some of the most potent (estimated) compounds were selected from the final refined hits and suggested for further experimental investigation. Descriptors Catalytic Domain, Combinatorial Chemistry Techniques, Computer Simulation, Enzyme Inhibitors/chemistry/pharmacology, Models, Chemical, Models, Molecular, Protein Kinases/chemistry/metabolism, Structure-Activity Relationship Links Book Title Database Publisher Data Source Authors Chen,J. J., Liu,T. L., Yang,L. J., Li,L. L., Wei,Y. Q., Yang,S. Y. Original/Translated Title URL Date of Electronic PMCID Editors
High extraction efficiency for polar aromatic compounds in natural water samples using multiwalled carbon nanotubes/Nafion solid-phase microextraction coating	2009	Department of Chemistry and the Key Laboratory of Analytical Sciences of the Ministry of Education, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.A Periodical, Abbrev. J.Chromatogr.A Pub Date Free Form 25-Dec Volume 1216 Issue 52 Start Page 9143 Other Pages 9148 Notes JID: 9318488; 0 (Hydrocarbons, Aromatic); 0 (Nanotubes, Carbon); 0 (Water Pollutants, Chemical); 2009/04/20 [received]; 2009/06/25 [revised]; 2009/07/14 [accepted]; 2009/07/18 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-3778; 0021-9673 Accession Number PMID: 19660762 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.chroma.2009.07.025 [doi] Output Language Unknown(0) PMID 19660762 Abstract A novel solid-phase microextraction (SPME) fiber coated with multiwalled carbon nanotubes (MWCNTs)/Nafion was developed and applied for the extraction of polar aromatic compounds (PACs) in natural water samples. The characteristics and the application of this fiber were investigated. Electron microscope photographs indicated that the MWCNTs/Nafion coating with average thickness of 12.5microm was homogeneous and porous. The MWCNTs/Nafion coated fiber exhibited higher extraction efficiency towards polar aromatic compounds compared to an 85microm commercial PA fiber. SPME experimental conditions, such as fiber coating, extraction time, stirring rate, desorption temperature and desorption time, were optimized in order to improve the extraction efficiency. The calibration curves were linear from 0.01 to 10microgmL(-1) for five PACs studied except p-nitroaniline (from 0.005 to 10microgmL(-1)) and m-cresol (from 0.001 to 10microgmL(-1)), and detection limits were within the range of 0.03-0.57ngmL(-1). Single fiber and fiber-to-fiber reproducibility were less than 7.5 (n=7) and 10.0% (n=5), respectively. The recovery of the PACs spiked in natural water samples at 1microgmL(-1) ranged from 83.3 to 106.0%. Descriptors Adsorption, Hydrocarbons, Aromatic/chemistry, Limit of Detection, Nanotubes, Carbon/chemistry, Solid Phase Microextraction/instrumentation/methods, Water Pollutants, Chemical/chemistry Links Book Title Database Publisher Data Source Authors Chen,W., Zeng,J., Chen,J., Huang,X., Jiang,Y., Wang,Y., Chen,X. Original/Translated Title URL Date of Electronic 20090718 PMCID Editors
The characteristics of Barrett's esophagus: an analysis of 4120 cases in China	2009	Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Periodical, Abbrev. Dis.Esophagus Pub Date Free Form Volume 22 Issue 4 Start Page 348 Other Pages 353 Notes LR: 20091029; JID: 8809160; EIN: Dis Esophagus. 2009;22(5):475. Hou, Kiao-Hua [corrected to Hou, Xiao-hua]; RF: 42; 2009/01/23 [aheadofprint]; ppublish Place of Publication Australia ISSN/ISBN 1442-2050; 1120-8694 Accession Number PMID: 19191861 Language eng SubFile Comparative Study; Journal Article; Review; IM DOI 10.1111/j.1442-2050.2008.00924.x [doi] Output Language Unknown(0) PMID 19191861 Abstract Our objective was to investigate the endoscopic and clinico-pathological characteristics in patients with Barrett's esophagus (BE) in China. Using the terms 'Barrett's esophagus' and 'Barrett's esophagus, China' as key words, literatures published in Chinese and English journals were searched in Chinese data banks, as well as PubMed and ISI Web of Science from 1989 to 2007. An analysis was carried out with the standard inclusion and exclusion criteria. A total of 4120 cases were included in this study. BE was found in 2.44% of patients undergoing endoscopy for various symptoms of upper gastrointestinal tract diseases; the male : female ratio was 2.09 : 1, the average age of detection of BE was 53.15 years old, and 51% of patients with BE had typical symptoms for gastroesophageal reflux disease (GERD). The island-type BE was predominant (56.80%), and the occurrence of BE with special intestinal metaplasia (SIM) was 36.58%, but SIM was more common in tongue-type BE than island-type and circumferential-type BE (both P < 0.001), as well as in long segment BE (LSBE) than in short segment BE (SSBE) (P < 0.001). A total of 46.39% of patients had Helicobacter pylori infection. The mean length of follow up was 2 years in 492 patients. The incidence of adenocarcinoma was 0.61% patient-years of total follow up. In China, the endoscopic prevalence of BE is lower, but the average age of diagnosis is younger; a high proportion of H. pylori infection is found in patients with BE, and about half of the patients have no typical symptoms of GERD; the tongue-type BE and the LSBE are apt to SIM. Descriptors Adenocarcinoma/epidemiology/pathology, Adolescent, Age Distribution, Aged, Aged, 80 and over, Barrett Esophagus/epidemiology/pathology, Cell Transformation, Neoplastic/pathology, China/epidemiology, Confidence Intervals, Esophageal Neoplasms/epidemiology/pathology, Esophagoscopy/methods, Female, Humans, Male, Middle Aged, Precancerous Conditions/pathology, Prevalence, Probability, Prognosis, Risk Assessment, Sex Distribution, Young Adult Links Book Title Database Publisher Data Source Authors Chen,X., Zhu,L. R., Hou,X. H. Original/Translated Title URL Date of Electronic 20090123 PMCID Editors

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