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Influence of metals on rhinosinusal polyposis in Sardinian population (Italy) 2016 Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.; INBB-National Institute of Biostructures and Biosystems, Sassari, Italy.; Division of Otorhinolaryngology, Department of Surgery, Microsurgery and Medi
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Journal Article
Periodical, Full
Environmental science and pollution research international
Periodical, Abbrev.
Environ.Sci.Pollut.Res.Int.
Pub Date Free Form
13-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160814; JID: 9441769; OTO: NOTNLM; 2016/03/04 [received]; 2016/08/04 [accepted]; 2016/08/13 [aheadofprint]; aheadofprint
Place of Publication
ISSN/ISBN
1614-7499; 0944-1344
Accession Number
PMID: 27522207
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
10.1007/s11356-016-7406-6 [doi]
Output Language
Unknown(0)
PMID
27522207
Abstract
Metals have strong toxic effects in humans and can act as immunoregulatory factors. The purpose of our study was to determine whether the concentrations of metals are associated with the clinical course of nasal polyposis (NP). We measured the concentrations of 10 metals and non-metal (Zn, Mn, Se, Fe, Cr, Ni, Pb, Al, Cd, and Cu) in 58 patients with NP, and 29 controls with a healthy nasal mucosa. We used electron microscopy to compare the ultrastructural features of the nasal mucosa between NP patients and healthy controls. Concentrations of metals in nasal polyps and healthy mucosa were determined by mass spectrometry. Transmission electron microscopic (TEM) and scanning electron microscopic (SEM) images of the nasal mucosa were obtained. The mean tissue concentrations of all 10 metals and non-metal were significantly lower in NP patients than in healthy controls (P
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Database
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Data Source
Authors
Asara,Y., Melis,A., De Luca,L.M., Bozzo,C., Castiglia,P., Chessa,G., Piras,P., Karligkiotis,A., Bandiera,P., Malaguarnera,M., Marchal,J.A., Madeddu,R.
Original/Translated Title
URL
Date of Electronic
20160813
PMCID
Editors
Prevalence and associated factors of low bone mass in adults with systemic lupus erythematosus 2016 University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic D
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Print(0)
Ref Type
Journal Article
Periodical, Full
Lupus
Periodical, Abbrev.
Lupus
Pub Date Free Form
13-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160813; CI: (c) The Author(s) 2016; JID: 9204265; OTO: NOTNLM; 2016/04/26 [received]; 2016/07/25 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1477-0962; 0961-2033
Accession Number
PMID: 27522094
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
0961203316664597 [pii]
Output Language
Unknown(0)
PMID
27522094
Abstract
BACKGROUND: Systemic lupus erythematosus (SLE) patients are often treated with glucocorticoids, which place them at risk of bone loss. OBJECTIVES: The objectives of this article are to determine: (1) the prevalence of low bone mineral density (BMD) and factors associated with low BMD and (2) the prevalence of symptomatic fragility fractures in inception patients of the Toronto Lupus Cohort (TLC). METHODS: Prospectively collected data from the TLC (1996-2015) of inception patients' first BMD were analyzed. For pre-menopausal women/males
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Database
Publisher
Data Source
Authors
Cramarossa,G., Urowitz,M.B., Su,J., Gladman,D., Touma,Z.
Original/Translated Title
URL
Date of Electronic
20160813
PMCID
Editors
A global view on cancer incidence and national levels of the Human Development Index 2016 Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, 69372, CEDEX 08, France.; Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, 69372, CEDEX
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of cancer
Periodical, Abbrev.
Int.J.Cancer
Pub Date Free Form
13-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160813; CI: (c) 2016; JID: 0042124; 2016/06/03 [received]; 2016/07/31 [revised]; 2016/08/10 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1097-0215; 0020-7136
Accession Number
PMID: 27522007
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
10.1002/ijc.30382 [doi]
Output Language
Unknown(0)
PMID
27522007
Abstract
Socioeconomic factors are associated with cancer incidence through complex and variable pathways. We assessed cancer incidence for all cancers combined and 27 major types according to national human development levels. Using GLOBOCAN data for 184 countries, age-standardized incidence rates (ASRs) were assessed by four levels (low, medium, high, very high) of the Human Development Index (HDI), a composite index of life expectancy, education, and gross national income. A strong positive relationship between overall cancer incidence and HDI level was observed. When comparing the ASR in very high HDI regions to that in low HDI regions, we observed a positive association ranging from 2-14 and 2-11 times higher in males and females, respectively, depending on the cancer type. Positive dose-response relationships between the ASR and HDI level were observed in both sexes for the following cancer types: lung, pancreas, leukemia, gallbladder, colorectum, brain/nervous system, kidney, multiple myeloma, and thyroid. Positive associations were also observed for testicular, bladder, lip/oral cavity, and other pharyngeal cancers, Hodgkin lymphoma, and melanoma in males, and corpus uteri, breast, and ovarian cancers and non-Hodgkin lymphoma in females. A negative dose-response relationship was observed for cervical and other pharyngeal cancers and Kaposi sarcoma in females. Although the relationship between incidence and the HDI remained when assessed at the country-specific level, variations in risk within HDI levels were also observed. We highlight positive and negative associations between incidence and human development for most cancers, which will aid the planning of cancer control priorities among countries undergoing human development transitions. This article is protected by copyright. All rights reserved.
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Book Title
Database
Publisher
UICC
Data Source
Authors
Fidler,M.M., Soerjomataram,I., Bray,F.
Original/Translated Title
URL
Date of Electronic
20160813
PMCID
Editors
Abstinence Reinforcement Therapy (ART) for rural veterans: Methodology for an mHealth smoking cessation intervention 2016 VA Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), Durham, NC 27705, United States; Durham VA Medical Center, Durham, NC 27705, United States. Electronic address: sarah.wilson@duke.edu.; Durham VA Medical Center, Durham, NC 2
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Print(0)
Ref Type
Journal Article
Periodical, Full
Contemporary clinical trials
Periodical, Abbrev.
Contemp.Clin.Trials
Pub Date Free Form
10-Aug
Volume
50
Issue
Start Page
157
Other Pages
165
Notes
LR: 20160821; CI: Copyright (c) 2016; JID: 101242342; OTO: NOTNLM; 2016/06/13 [received]; 2016/08/05 [revised]; 2016/08/09 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1559-2030; 1551-7144
Accession Number
PMID: 27521811
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S1551-7144(16)30206-3 [pii]
Output Language
Unknown(0)
PMID
27521811
Abstract
INTRODUCTION: Smoking is the most preventable cause of morbidity and mortality in U.S. veterans. Rural veterans in particular have elevated risk for smoking and smoking-related illness. However, these veterans underutilize smoking cessation treatment, which suggests that interventions for rural veterans should optimize efficacy and reach. OBJECTIVE: The primary goal of the current study is to evaluate the effectiveness of an intervention that combines evidenced based treatment for smoking cessation with smart-phone based, portable contingency management on smoking rates compared to a contact control intervention in a randomized controlled trial among rural Veteran smokers. Specifically, Veterans will be randomized to receive Abstinence Reinforcement Therapy (ART) which combines evidenced based cognitive-behavioral telephone counseling (TC), a tele-medicine clinic for access to nicotine replacement (NRT), and mobile contingency management (mCM) or a control condition (i.e., TC and NRT alone) that will provide controls for therapist, medication, time and attention effects. METHODS: Smokers were identified using VHA electronic medical records and recruited proactively via telephone. Participants (N=310) are randomized to either ART or a best practice control consisting of telephone counseling and telemedicine. Participating patients will be surveyed at 3-months, 6-months and 12-months post-randomization. The primary outcome measure is self-reported and biochemically validated prolonged abstinence at 6-month follow-up. DISCUSSION: This trial is designed to test the relative effectiveness of ART compared to a telehealth-only comparison group. Dissemination of this mHealth intervention for veterans in a variety of settings would be warranted if ART improves smoking outcomes for rural veterans and is cost-effective.
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Book Title
Database
Publisher
. Published by Elsevier Inc
Data Source
Authors
Wilson,S.M., Hair,L.P., Hertzberg,J.S., Kirby,A.C., Olsen,M.K., Lindquist,J.H., Maciejewski,M.L., Beckham,J.C., Calhoun,P.S.
Original/Translated Title
URL
Date of Electronic
20160810
PMCID
Editors
Impact and duration of brief surgeon-delivered smoking cessation advice on attitudes regarding nicotine dependence and tobacco harms for patients with peripheral arterial disease 2016 Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; VA Outcomes Group, White River Junction, VT. Electronic address: Karina.A.Newhall@hitchcock.org.; Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH.; Sectio
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annals of Vascular Surgery
Periodical, Abbrev.
Ann.Vasc.Surg.
Pub Date Free Form
10-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160813; CI: Published by Elsevier Inc.; JID: 8703941; 2016/02/06 [received]; 2016/05/31 [revised]; 2016/06/03 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1615-5947; 0890-5096
Accession Number
PMID: 27521828
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S0890-5096(16)30599-4 [pii]
Output Language
Unknown(0)
PMID
27521828
Abstract
BACKGROUND: Despite the recognized benefits of smoking cessation, many clinicians question if a brief smoking cessation intervention can help dedicated smokers with peripheral arterial disease understand nicotine dependence and harms related to smoking. We investigated the impact and durability of a multi-modal smoking cessation intervention on patient attitudes regarding nicotine dependence and the health effects of smoking. METHODS: We conducted a pilot cluster randomized trial of a brief smoking cessation intervention at eight vascular surgery practices between September 1, 2014 and August 31, 2015. Compared with control sites, patients at intervention sites received protocolized brief cessation counseling, medications and referrals to a quitline. After their clinic visit and again at 3 months, participants completed a brief survey about patient attitudes regarding nicotine dependence and the health effects of smoking. Responses to questions were analyzed using Chi2 and student's t-tests. RESULTS: All trial participants (n=156) complete the initial survey, and 75 (45%) participants completed the follow-up survey. Intervention and control patients both reported a greater than 30-pack-year history (80% vs 90%, p=0.07) and previous failed quit attempts (77% vs 78%, p=0.8). Compared to usual care, patients in the intervention group were more likely to describe hearing advice to quit from their surgeon (98% vs. 77%, p
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Database
Publisher
Data Source
Authors
Newhall,K., Suckow,B., Spangler,E., Brooke,B.S., Schanzer,A., Tan,T., Burnette,M., Edelen,M.O., Farber,A., Goodney,P., VAPOR investigators (complete list in Appendix)
Original/Translated Title
URL
Date of Electronic
20160810
PMCID
Editors
Tuberculosis, smoking and risk for lung cancer incidence and mortality 2016 Department of Public Health, Yonsei University Graduate School, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.; Department of Epidemiology, Bloomberg school of public health, Johns Hopkins Un
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of cancer
Periodical, Abbrev.
Int.J.Cancer
Pub Date Free Form
13-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160813; CI: (c) 2016; JID: 0042124; OTO: NOTNLM; 2015/10/27 [received]; 2016/06/30 [revised]; 2016/08/04 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1097-0215; 0020-7136
Accession Number
PMID: 27521774
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
10.1002/ijc.30384 [doi]
Output Language
Unknown(0)
PMID
27521774
Abstract
Among the exposures associated with risk for lung cancer, a history of tuberculosis is one potentially important factor, given the high prevalence of tuberculosis worldwide. A prospective cohort study was conducted to evaluate the associations of preexisting pulmonary tuberculosis with lung cancer incidence and mortality. The cohort consisted of 1,607,710 Korean adults covered by the National Health Insurance System who had a biennial national medical examination during 1997-2000. During up to 16 years of follow-up, there were 12,819 incident cases of lung cancer and 9,562 lung cancer deaths. Using Cox proportional hazards models and controlling for age, cigarette smoking and other covariates, the presence of underlying tuberculosis was significantly associated with increased risk for lung cancer incidence (HR 1.37 in men with 95% CI 1.29-1.45; HR 1.49 in women with 95% CI 1.28-1.74) and mortality (HR 1.43 in men with 95% CI 1.34-1.52; HR 1.53 in women with 95% CI 1.28-1.83). We also observed a dose-response relationship between number of cigarettes smoked daily and lung cancer risk. There was no evidence for synergism between a history of tuberculosis and smoking. The elevation in risk is relatively modest, particularly in comparison to that from smoking, and a prior history of TB is not likely to be useful risk indicator for clinical purposes. In populations with high prevalence of tuberculosis, it can be considered for incorporation into models for lung cancer risk prediction. This article is protected by copyright. All rights reserved.
Descriptors
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Book Title
Database
Publisher
UICC
Data Source
Authors
Hong,S., Mok,Y., Jeon,C., Jee,S.H., Samet,J.M.
Original/Translated Title
URL
Date of Electronic
20160813
PMCID
Editors
Entering out-of-home care during childhood: Cumulative incidence study in Canada and Australia 2016 Telethon Kids Institute, The University of Western Australia, Perth, Australia. Electronic address: Melissa.O'Donnell@telethonkids.org.au.; Telethon Kids Institute, The University of Western Australia, Perth, Australia. Electronic address: Miriam.Maclean@
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Child abuse & neglect
Periodical, Abbrev.
Child Abuse Negl.
Pub Date Free Form
10-Aug
Volume
59
Issue
Start Page
78
Other Pages
87
Notes
LR: 20160813; CI: Copyright (c) 2016; JID: 7801702; OTO: NOTNLM; 2015/11/04 [received]; 2016/07/26 [revised]; 2016/07/31 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1873-7757; 0145-2134
Accession Number
PMID: 27521764
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S0145-2134(16)30162-4 [pii]
Output Language
Unknown(0)
PMID
27521764
Abstract
Cumulative incidence provides a more accurate indicator than annual incidence rates of the number of children who experience out-of-home care during childhood. The study utilises a cohort of all children born in Western Australia (WA) 1994-2005 and Manitoba 1998-2008 using de-identified linked data. Life tables were used to calculate the age-specific cumulative incidence over time and for at-risk groups. Cox regression was used to compare risk factors for entry to care. Manitoba had a larger proportion of children entering care compared to WA (9.4% vs 1.5% by age 12). Over time children entered care at a younger age in both WA (HR=1.5, CI:1.4-1.5) and Manitoba (HR=1.5, CI:1.5-1.6). Similar factors were associated with earlier age care entries in both countries including: socioeconomic disadvantage, young maternal age, maternal hospital admissions for mental health issues, substance misuse and assault. Supplementary analysis for WA showed a time trend with young children (
Descriptors
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Book Title
Database
Publisher
The Authors. Published by Elsevier Ltd.
Data Source
Authors
O'Donnell,M., Maclean,M., Sims,S., Brownell,M., Ekuma,O., Gilbert,R.
Original/Translated Title
URL
Date of Electronic
20160810
PMCID
Editors
Does KMnO4 preoxidation reduce the genotoxicity of disinfection by-products? 2016 Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.; Key Laboratory of Drinking Wa
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Chemosphere
Periodical, Abbrev.
Chemosphere
Pub Date Free Form
10-Aug
Volume
163
Issue
Start Page
73
Other Pages
80
Notes
LR: 20160813; CI: Copyright (c) 2016; JID: 0320657; OTO: NOTNLM; 2016/06/07 [received]; 2016/08/01 [revised]; 2016/08/02 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1879-1298; 0045-6535
Accession Number
PMID: 27521641
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S0045-6535(16)31035-9 [pii]
Output Language
Unknown(0)
PMID
27521641
Abstract
Potassium permanganate (KMnO4) preoxidation is capable of affecting the formation of disinfection by-products (DBPs). However, few studies have focused on the toxicity of DBPs after KMnO4 preoxidation, which is an important index to evaluate alternative treatment processes. Herein genotoxicity (SOS/umu test) was used to clarify the impact of KMnO4 preoxidation on the chlorination byproducts produced from two representative precursors, tyrosine (Tyr) and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (BP-4), and their mixture. Results revealed that although KMnO4 could not oxidize BP-4, after chlorination KMnO4 could oxidize the chlorination byproducts of BP-4 and thus decrease the genotoxicity production. For Tyr, KMnO4 preoxidation could increase or decrease the genotoxicity of DBPs, depending on the KMnO4 dose. The optimal initial molar ratio of KMnO4 to Tyr was confirmed to be 1:1. It has been proved that both the oxidation of Tyr by KMnO4 and manganese dioxide (MnO2, the reduction product of KMnO4) and the oxidation of chlorination byproducts by MnO2 can decrease the genotoxicity production of chlorinated Tyr. Remarkably, during chlorination, the competition of manganese(II) oxidation with organic oxidation can result in less chlorine reacting with organics, to induce an increase in genotoxicity. This is the main cause for the increase in genotoxicity of chlorinated Tyr after KMnO4 preoxidation. Additionally, the genotoxicity of the chlorinated mixture was shifted from being higher than the sum of individual genotoxicities of the chlorinated precursors to being lower than their sum with increasing KMnO4 dosage, due to the combined effects between the preoxidation-chlorination products from the two compounds.
Descriptors
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Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Chang,Y., Bai,Y., Qu,J.
Original/Translated Title
URL
Date of Electronic
20160810
PMCID
Editors
Detoxification from opiates during pregnancy: additional risks 2016 HSE Addiction Services, Dublin, Ireland.; Rotunda Hospital, Dublin, Ireland.; Rotunda Hospital/Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: bcleary@rotunda.ie.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
American Journal of Obstetrics and Gynecology
Periodical, Abbrev.
Am.J.Obstet.Gynecol.
Pub Date Free Form
10-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160815; JID: 0370476; 2016/06/22 [received]; 2016/08/02 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1097-6868; 0002-9378
Accession Number
PMID: 27521465
Language
ENG
SubFile
LETTER
DOI
S0002-9378(16)30569-5 [pii]
Output Language
Unknown(0)
PMID
27521465
Abstract
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Gleeson,J., Eogan,M., Cleary,B.
Original/Translated Title
URL
Date of Electronic
20160810
PMCID
Editors
Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection 2016 Corgenix, Broomfield, Colorado Department of Microbiology and Immunology.; Galveston National Laboratory, University of Texas Medical Branch.; Department of Microbiology and Immunology.; Lassa Fever Program, Kenema Government Hospital Ministry of Health a
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Journal of infectious diseases
Periodical, Abbrev.
J.Infect.Dis.
Pub Date Free Form
11-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160813; CI: (c) The Author 2016; JID: 0413675; OTO: NOTNLM; aheadofprint
Place of Publication
ISSN/ISBN
1537-6613; 0022-1899
Accession Number
PMID: 27521365
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
jiw261 [pii]
Output Language
Unknown(0)
PMID
27521365
Abstract
BACKGROUND: The 2013-2016 West African Ebola virus disease (EVD) epidemic is the largest recorded. Triage on the basis of clinical signs had limited success, and the time to diagnosis by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) could exceed 5 days. Here we describe the development and field validation of the ReEBOV Antigen Rapid Test (ReEBOV RDT) to aid triage of individuals with suspected EVD. METHODS: Samples from patients with suspected EVD were submitted to Kenema Government Hospital, Sierra Leone, for Lassa fever and EVD screening throughout 2014. Banked residual clinical samples were tested in November 2014 and January 2015 in a blinded field trial to estimate the clinical effectiveness of the ReEBOV RDT, compared with EBOV-specific qRT-PCR. RESULTS: Preliminary ReEBOV RDT performance demonstrated a positive percentage agreement (PPA) of 91.1% (195 of 214 results; 95% confidence interval [CI], 86.5%-94.6%) and a negative percentage agreement (NPA) of 90.2% (175 of 194; 95% CI, 85.1%-94.0%). The final estimates used by the Food and Drug Administration to determine whether to grant emergency use authorization for the test, which excluded a qRT-PCR reference method threshold cutoff, were a PPA of 62.1% (72 of 116 results; 95% CI, 52.6%-70.9%) and a NPA of 96.7% (58 of 60; 95% CI, 88.5%-99.6%), with a diagnostic likelihood of 18.6. A subsequent, independent evaluation by the World Health Organization generated results consistent with the preliminary performance estimates. CONCLUSIONS: The ReEBOV RDT demonstrated the potential to provide clinically effective rapid and accurate point-of-care test results and, thus, to be a powerful tool for increasing triage efficiency.
Descriptors
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Book Title
Database
Publisher
. Published by Oxford University Press for the Infectious Diseases Society of America
Data Source
Authors
Boisen,M.L., Cross,R.W., Hartnett,J.N., Goba,A., Momoh,M., Fullah,M., Gbakie,M., Safa,S., Fonnie,M., Baimba,F., Koroma,V.J., Geisbert,J.B., McCormick,S., Nelson,D.K., Millett,M.M., Oottamasathien,D., Jones,A.B., Pham,H., Brown,B.L., Shaffer,J.G., Schieffelin,J.S., Kargbo,B., Gbetuwa,M., Gevao,S.M., Wilson,R.B., Pitts,K.R., Geisbert,T.W., Branco,L.M., Khan,S.H., Grant,D.S., Garry,R.F.
Original/Translated Title
URL
Date of Electronic
20160811
PMCID
Editors