WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Encountering a Neglected Area of a Healthcare System: A Decade of Improvement in Cancer Pain Clinical Practice in Iran	2016	Department of Pain and Palliation, Mahak's Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran.; Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran.; Pain Research Center, Iran University of Medi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pain and therapy Periodical, Abbrev. Pain Ther. Pub Date Free Form 11-Aug Volume Issue Start Page Other Pages Notes LR: 20160812; JID: 101634491; OTO: NOTNLM; 2016/04/28 [received]; 2016/08/11 [aheadofprint]; aheadofprint Place of Publication ISSN/ISBN 2193-8237 Accession Number PMID: 27515841 Language ENG SubFile JOURNAL ARTICLE DOI 10.1007/s40122-016-0055-0 [doi] Output Language Unknown(0) PMID 27515841 Abstract BACKGROUND: With the increase in the prevalence of cancer, cancer-related issues also deserve more attention especially in developing countries where there is already limited access to high-quality healthcare. Cancer-related pain, the most common and the most annoying one, is not only a symptom but also an important subspecialty and its management is still challenging. OBJECTIVES: To assess the level of pain and cancer pain knowledge in Iran in comparison with the whole world. MATERIALS AND METHOD: A search of the literature including papers published in PubMed before March 2016 was carried out. RESULTS: There have been an increasing number of publications on pain since 1842 and a growing number of publications on cancer pain since 1929. There has also been remarkable growth in our understanding of cancer pain, particularly since 2010. More than one-third of studies on pain and cancer-related pain were published after 2010. CONCLUSION: There is a need to be more inventive with the management of cancer-related issues, especially pain in developing countries, to maximize the quality and quantity of healthcare delivery to cancer-stricken patients. It seems that non-governmental organizations like MAHAK can play a significant role in this goal. Descriptors Links Book Title Database Publisher Data Source Authors Gharehdaghi,F.A., Gorginzadeh,M., Safari,S. Original/Translated Title URL Date of Electronic 20160811 PMCID Editors
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development	2016	Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massac	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nature communications Periodical, Abbrev. Nat.Commun. Pub Date Free Form 12-Aug Volume 7 Issue Start Page 12157 Other Pages Notes JID: 101528555; 2015/11/05 [received]; 2016/06/07 [accepted]; epublish Place of Publication England ISSN/ISBN 2041-1723; 2041-1723 Accession Number PMID: 27515585 Language eng SubFile Journal Article; IM DOI 10.1038/ncomms12157 [doi] Output Language Unknown(0) PMID 27515585 Abstract Somatic mutations have long been implicated in aging and disease, but their impact on fitness and function is difficult to assess. Here by analysing human cancer genomes we identify mutational patterns associated with aging. Our analyses suggest that age-associated mutation load and burden double approximately every 8 years, similar to the all-cause mortality doubling time. This analysis further reveals variance in the rate of aging among different human tissues, for example, slightly accelerated aging of the reproductive system. Age-adjusted mutation load and burden correlate with the corresponding cancer incidence and precede it on average by 15 years, pointing to pre-clinical cancer development times. Behaviour of mutation load also exhibits gender differences and late-life reversals, explaining some gender-specific and late-life patterns in cancer incidence rates. Overall, this study characterizes some features of human aging and offers a mechanism for age being a risk factor for the onset of cancer. Descriptors Links Book Title Database Publisher Data Source Authors Podolskiy,D.I., Lobanov,A.V., Kryukov,G.V., Gladyshev,V.N. Original/Translated Title URL Date of Electronic 20160812 PMCID Editors
Merkel Cell Carcinoma: rising incidence in the East of England	2016	Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.; National Cancer Registration Service, Public Health England, Cambridge, UK.; Department of Pathology, Norfolk and Norwich University Hospital, Norwich, UK.; Department of De	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the European Academy of Dermatology and Venereology : JEADV Periodical, Abbrev. J.Eur.Acad.Dermatol.Venereol. Pub Date Free Form 12-Aug Volume Issue Start Page Other Pages Notes LR: 20160812; CI: (c) 2016; JID: 9216037; 2016/03/31 [received]; 2016/05/19 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1468-3083; 0926-9959 Accession Number PMID: 27515234 Language ENG SubFile JOURNAL ARTICLE DOI 10.1111/jdv.13828 [doi] Output Language Unknown(0) PMID 27515234 Abstract BACKGROUND: Merkel Cell Carcinoma (MCC) is an infrequent but highly aggressive skin cancer. Five-year survival rates are poor, as there are high rates of metastases at primary diagnoses. Recurrences are also common. There is controversy about actual incidence rates which vary considerably between developed countries with majority populations of fair skin types. OBJECTIVES: We report the age-standardized incidence rates of MCC for both males and females from the East of England, and use linear regression analyses to estimate numbers of cases for 2020 and 2025 to aid healthcare planning and allocation of resources. METHODS: All cases of MCC diagnosed histopathologically between 1st January 2004 and 31st December 2013 were extracted from the databases of the Eastern Office, National Cancer Registration Service, Public Health England, and the Pathology department of the Norfolk and Norwich University Hospital, which serves as the tertiary referral centre for the region. Age-standardization incidence rate calculations (ASIs) and linear regression analyses were performed. RESULTS: The ASIs for males and females were 0.70 and 1.08 per 100 000 person-years respectively. The total age-adjusted incidence rate was therefore 1.78 per 100 000 person-years. The ratio of female: male disease was 3:2. The total number of cases for this region over the time period studied was 73. There has been a threefold increase over this period. Estimated cases for this region are 17 in 2020, and 22 in 2025. Estimated UK cases for 2020 are 920, and 1134 in 2025. CONCLUSIONS: MCC is increasing steadily in the East of England, and has risen threefold over the last 10 years and is similar to the highest reported rates from Western Australia. These data are 12-fold higher than previous UK estimates, and suggest that the incidence rate is also rising in other regions of the UK. Descriptors Links Book Title Database Publisher European Academy of Dermatology and Venereology Data Source Authors Goon,P.K., Greenberg,D.C., Igali,L., Levell,N.J. Original/Translated Title URL Date of Electronic 20160812 PMCID Editors
Home visiting and perinatal smoking: a mixed-methods exploration of cessation and harm reduction strategies	2016	PolicyLab, The Children's Hospital of Philadelphia, 3535 Market, Suite 1424, Philadelphia, PA, 19104, USA. griffish@email.chop.edu.; PolicyLab, The Children's Hospital of Philadelphia, 3535 Market, Suite 1424, Philadelphia, PA, 19104, USA.; Division of Ge	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 11-Aug Volume 16 Issue 1 Start Page 764 Other Pages 016-3464-4 Notes LR: 20160817; JID: 100968562; OID: NLM: PMC4982407; OTO: NOTNLM; 2016/01/20 [received]; 2016/08/05 [accepted]; 2016/08/11 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 27514836 Language eng SubFile Journal Article; IM DOI 10.1186/s12889-016-3464-4 [doi] Output Language Unknown(0) PMID 27514836 Abstract BACKGROUND: Home visiting programs represent an important primary prevention strategy for adverse prenatal health behaviors; the various ways in which home visiting programs impact prenatal smoking cessation and reduction behaviors remain understudied. METHODS: Mixed methods approach using a retrospective cohort of propensity score matched home visiting clients and local-area comparison women with first births between 2008-2014 in a large Northeast state. Multivariable logistic and linear regression estimated third trimester prenatal tobacco smoking cessation and reduction. Additionally, qualitative interviews were conducted with 76 home visiting clients. RESULTS: A program effect was seen for smoking cessation such that clients who smoked less than ten cigarettes per day and those who smoked 20 or more cigarettes per day during the first trimester were more likely to achieve third trimester cessation than comparison women (p Descriptors Links Book Title Database Publisher Data Source Authors Griffis,H., Matone,M., Kellom,K., Concors,E., Quarshie,W., French,B., Rubin,D., Cronholm,P.F. Original/Translated Title URL Date of Electronic 20160811 PMCID PMC4982407 Editors
Adolescents' health choices related rights, duties and responsibilities: An integrative review	2016	University of Eastern Finland, Finland tanjamoi@student.uef.fi.; University of Eastern Finland, Finland; Kuopio Social and Healthcare Services, Finland.; University of Salford, UK.; University of Eastern Finland, Finland.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nursing ethics Periodical, Abbrev. Nurs.Ethics Pub Date Free Form 11-Aug Volume Issue Start Page Other Pages Notes LR: 20160812; CI: (c) The Author(s) 2016; JID: 9433357; OTO: NOTNLM; aheadofprint Place of Publication ISSN/ISBN 1477-0989; 0969-7330 Accession Number PMID: 27514739 Language ENG SubFile JOURNAL ARTICLE DOI 0969733016654316 [pii] Output Language Unknown(0) PMID 27514739 Abstract BACKGROUND: Although the link between adolescents' health choices in relation to rights, duties and responsibilities is acknowledged, little is studied in this subject. AIM: To identify, describe and synthesize previous studies on adolescents' health choices in relation to rights, duties and responsibilities. ETHICAL CONSIDERATIONS: Ethical approval is not needed as it is an integrative review of published literature. METHOD: The integrative review was used to review and synthesize current knowledge. Electronic and manual searches from 2009 to March 2014 were used to systematically identify earlier studies. RESULTS: The review identified 13 studies. Adolescents' health choices were linked to unsuccessfully exercised rights, arising from questioned autonomy and freedom, and their duties were hardly mentioned. CONCLUSION: Research into adolescents' health choices in relation to their rights, duties and responsibilities is still methodologically fragmented. In future, more research is needed to support adolescents' health promotion initiatives and increase their involvement opportunities. Descriptors Links Book Title Database Publisher Data Source Authors Moilanen,T., Pietila,A.M., Coffey,M., Kangasniemi,M. Original/Translated Title URL Date of Electronic 20160811 PMCID Editors
Visual Analysis of MOOC Forums with iForum	2016		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full IEEE Transactions on Visualization and Computer Graphics Periodical, Abbrev. IEEE Trans.Vis.Comput.Graph. Pub Date Free Form 5-Aug Volume Issue Start Page Other Pages Notes LR: 20160811; JID: 9891704; aheadofprint Place of Publication ISSN/ISBN 1941-0506; 1077-2626 Accession Number PMID: 27514047 Language ENG SubFile JOURNAL ARTICLE DOI 10.1109/TVCG.2016.2598444 [doi] Output Language Unknown(0) PMID 27514047 Abstract Discussion forums of Massive Open Online Courses (MOOC) provide great opportunities for students to interact with instructional staff as well as other students. Exploration of MOOC forum data can offer valuable insights for these staff to enhance the course and prepare the next release. However, it is challenging due to the large, complicated, and heterogeneous nature of relevant datasets, which contain multiple dynamically interacting objects such as users, posts, and threads, each one including multiple attributes. In this paper, we present a design study for developing an interactive visual analytics system, called iForum, that allows for effectively discovering and understanding temporal patterns in MOOC forums. The design study was conducted with three domain experts in an iterative manner over one year, including a MOOC instructor and two official teaching assistants. iForum offers a set of novel visualization designs for presenting the three interleaving aspects of MOOC forums (i.e., posts, users, and threads) at three different scales. To demonstrate the effectiveness and usefulness of iForum, we describe a case study involving field experts, in which they use iForum to investigate real MOOC forum data for a course on JAVA programming. Descriptors Links Book Title Database Publisher Data Source Authors Fu,S., Zhao,J., Cui,W., Qu,H. Original/Translated Title URL Date of Electronic 20160805 PMCID Editors
Elemental and molecular profiling of licit, illicit, and niche tobacco	2016	Centre for Materials Science, Division of Chemistry, University of Central Lancashire, Fylde Road, PR1 2HE, United Kingdom; Centre for Regional and Rural Futures, Deakin University, Locked Bag 20000, Geelong, Victoria 3220, Australia. Electronic address:	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Forensic science international Periodical, Abbrev. Forensic Sci.Int. Pub Date Free Form 1-Aug Volume 266 Issue Start Page 549 Other Pages 554 Notes LR: 20160811; CI: Copyright (c) 2016; JID: 7902034; OTO: NOTNLM; 2016/04/15 [received]; 2016/07/20 [revised]; 2016/07/25 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1872-6283; 0379-0738 Accession Number PMID: 27514016 Language ENG SubFile JOURNAL ARTICLE DOI S0379-0738(16)30327-9 [pii] Output Language Unknown(0) PMID 27514016 Abstract The recognition of differences between regulated large-scale mass manufactured products and the uncontrolled cultivation of tobaccos for illicit purposes plays a significant role within identification of provenance. This research highlights X-ray fluorescence and Fourier transform infrared spectroscopy as useful analytical techniques for the rapid identification of tobacco samples of unknown provenance. Identification of key discriminative features within each technique allowed for the development of typical characteristic profiles for each type of tobacco. Analysis using X-ray fluorescence highlights chlorine, potassium, calcium and iron as key elemental indicators of tobacco provenance. Significant levels of chlorine seen within Snus samples prompted attempts to visualise chlorine containing regions and structures within the sample. Scanning electron microscopy images showed crystalline structures visible within the Snus tobacco, structures which Energy dispersive X-ray spectroscopy qualitatively confirmed to contain chlorine. Chloride levels within Snus samples were quantified using ion chromatography with levels found to range between 0.87mgmL-1 and 1.28mg. Additionally, FTIR indicated that absorbances attributed to carbonyl stretching at 1050-1150cm-1, alkane bending at 1350-1480cm-1 and amide I stretching at 1600-1700cm-1 highlighting a spectral fingerprint region that allowed for the clear differentiation between different types of tobaccos using PCA analysis, but was limited by differentiation between provenance of cigarettes and hand rolled tobacco. X-ray fluorescence and Fourier transform infrared spectroscopy yielded different information with regards tobacco discrimination and provenance, however both methods overall analysis time and cost reduced indicating usefulness as potential handheld analytical techniques in the field. Descriptors Links Book Title Database Publisher Elsevier Ireland Ltd Data Source Authors Quayle,K., Clemens,G., Sorribes,T.G., Kinvig,H.M., Stevenson,P.G., Conlan,X.A., Baker,M.J. Original/Translated Title URL Date of Electronic 20160801 PMCID Editors
Stages of physical dependence in New Zealand smokers: Prevalence and correlates	2016	University of Canterbury, Christchurch, New Zealand; Health Promotion Agency, Wellington, New Zealand.; Health Promotion Agency, Wellington, New Zealand.; Health Promotion Agency, Wellington, New Zealand.; Health Promotion Agency, Wellington, New Zealand.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Dec Volume 63 Issue Start Page 161 Other Pages 164 Notes CI: Copyright (c) 2016; JID: 7603486; OTO: NOTNLM; 2016/05/13 [received]; 2016/07/25 [revised]; 2016/07/30 [accepted]; 2016/08/01 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1873-6327; 0306-4603 Accession Number PMID: 27513594 Language eng SubFile Journal Article; IM DOI 10.1016/j.addbeh.2016.07.022 [doi] Output Language Unknown(0) PMID 27513594 Abstract BACKGROUND: Physically dependent smokers experience symptoms of wanting, craving or needing to smoke when too much time has passed since the last cigarette. There is interest in whether wanting, craving and needing represent variations in the intensity of a single physiological parameter or whether multiple physiological processes may be involved in the developmental progression of physical dependence. AIM: Our aim was to determine how a population of cigarette smokers is distributed across the wanting, craving and needing stages of physical dependence. METHODS: A nationwide survey of 2594 New Zealanders aged 15years and over was conducted in 2014. The stage of physical dependence was assessed using the Levels of Physical Dependence measure. Ordinal logistic regression analysis was used to assess relations between physical dependence and other variables. RESULTS: Among 590 current smokers (weighted 16.2% of the sample), 22.3% had no physical dependence, 23.5% were in the Wanting stage, 14.4% in the Craving stage, and 39.8% in the Needing stage. The stage of physical dependence was predicted by daily cigarette consumption, and the time to first cigarette, but not by age, gender, ethnicity or socioeconomic status. CONCLUSION: Fewer individuals were in the craving stage than either the wanting or needing stages. The resulting inverted U-shaped curve with concentrations at either extreme is difficult to explain as a variation of a single biological parameter. The data support an interpretation that progression through the stages of wanting, craving and needing may involve more than one physiological process. WHAT THIS RESEARCH ADDS: Physical dependence to tobacco develops through a characteristic sequence of wanting, craving and needing which correspond to changes in addiction pathways in the brain. It is important to neuroscience research to determine if the development of physical dependence involves changes in a single brain process, or multiple processes. Our data suggests that more than one physiologic process is involved in the progression of physical dependence. Descriptors Links Book Title Database Publisher Elsevier Ltd Data Source Authors Walton,D., Newcombe,R., Li,J., Tu,D., DiFranza,J.R. Original/Translated Title URL Date of Electronic 20160801 PMCID Editors
Cultural buffering as a protective factor against electronic cigarette use among Hispanic emergency department patients	2016	Department of Emergency Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. Electronic address: chun	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Dec Volume 63 Issue Start Page 155 Other Pages 160 Notes CI: Copyright (c) 2016; JID: 7603486; OTO: NOTNLM; 2016/03/28 [received]; 2016/07/21 [revised]; 2016/07/30 [accepted]; 2016/08/01 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1873-6327; 0306-4603 Accession Number PMID: 27513593 Language eng SubFile Journal Article; IM DOI 10.1016/j.addbeh.2016.07.020 [doi] Output Language Unknown(0) PMID 27513593 Abstract INTRODUCTION: Hispanics in the U.S. historically use tobacco at lower rates than other racial and ethnic groups. Cultural buffering, the process by which aspects of traditional Hispanic culture delay the adoption of unhealthy behaviors, is believed to be a protective factor against tobacco use. Electronic cigarettes (e-cigarettes) are a new tobacco product that have not been extensively studied, and it is unknown if cultural factors that protect against tobacco use will buffer against e-cigarette use among the Hispanic population. METHODS: This cross-sectional study was conducted at the emergency department (ED) in a safety-net hospital in 2014. Patients visiting the ED participated in a survey assessing demographics and substance use. Cultural buffering was operationalized as participants' primary language spoken at home. Multivariate logistic regression and generalized estimating equations examined the association between Hispanic cultural buffering and e-cigarette ever-use. RESULTS: Of the 1476 Hispanic ED patients (age: 46.6M+/-14.5SD, 49.3% male), 7.6% reported e-cigarette ever-use and 11.1% reported current combustible cigarette use. In adjusted models, Spanish speakers were half as likely to report e-cigarette ever-use (O.R.: 0.54, 95% C.I.: 0.34-0.84, p=0.007), compared with English speakers. Combustible cigarette use remained the most significant factor associated with e-cigarette ever-use (O.R.: 9.28, 95% C.I.:7.44-11.56, p Descriptors Links Book Title Database Publisher . Published by Elsevier Ltd Data Source Authors Lam,C.N., Goldenson,N.I., Burner,E., Unger,J.B. Original/Translated Title URL Date of Electronic 20160801 PMCID Editors
Smoking habits and benign prostatic hyperplasia: A systematic review and meta-analysis of observational studies	2016	Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Medicine Periodical, Abbrev. Medicine (Baltimore) Pub Date Free Form Aug Volume 95 Issue 32 Start Page e4565 Other Pages Notes JID: 2985248R; ppublish Place of Publication United States ISSN/ISBN 1536-5964; 0025-7974 Accession Number PMID: 27512883 Language eng SubFile Journal Article; AIM; IM DOI 10.1097/MD.0000000000004565 [doi] Output Language Unknown(0) PMID 27512883 Abstract Previous studies have warned against the promoting effects of cigarette smoking on benign prostatic hyperplasia (BPH). In contrast, some have argued that smoking confers a protective effect regarding BPH, while others have observed an aggravated effect. Thus, we performed this meta-analysis to determine whether cigarette use is associated with BPH risk.To identify articles from observational studies of relevance, a search was performed concurrent to March 21, 2016, on PubMed, Web of Science, Cochrane, EBSCO, and EMBASE databases. Random-effect model, according to the heterogeneity, was calculated to reveal the relative risks (RRs) and corresponding 95% confidence intervals (CIs).Eight articles were included in this meta-analysis, representing data for 44,100 subjects, of which 5221 (11.8%) had BPH as defined according to the criteria. Seven reports are concerned with analysis between nonsmokers and ex-smokers, in which no significant difference was observed (RR = 0.99, 95% CI 0.94-1.05). Another meta-analysis of 7 studies indicated an observable trend, but without significant difference between groups of nonsmokers and current smokers (RR = 1.17, 95% CI 0.98-1.41). Between groups of heavy (6 articles; RR = 1.02, 95% CI 0.84-1.24) and light smokers (5 articles; RR = 0.90, 95% CI 0.71-1.15), again no significant difference appears. Finally, we combined individuals as never-smokers and ever-smokers and still found no significant difference between the 2 groups of patients (RR = 1.03, 95% CI 0.92-1.15). Sensitivity analysis was displayed and confirmed the stability of the present results.Combined evidence from observational studies shows no significant association between cigarette smoking and BPH risk, either for ex-smokers or for current smokers. The trend of elevated BPH risk from smoking was observed only in current smokers compared with nonsmokers, while marginal significance was observed in comparing ever-smokers with never-smokers in operative patients with BPH. Descriptors Links Book Title Database Publisher Data Source Authors Xu,H., Fu,S., Chen,Y., Chen,Q., Gu,M., Wang,Z. Original/Translated Title URL Date of Electronic PMCID Editors

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