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The Sexunzipped trial: young people's views of participating in an online randomized controlled trial 2013 e-Health Unit, Research Department of Primary Care and Population Health, University College London, London, United Kingdom.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
12-Dec
Volume
15
Issue
12
Start Page
e276
Other Pages
Notes
LR: 20151119; ISRCTN/ISRCTN55651027; GR: G0701749/Medical Research Council/United Kingdom; JID: 100959882; OID: NLM: PMC3868966; OTO: NOTNLM; 2013/04/03 [received]; 2013/09/06 [accepted]; 2013/08/14 [revised]; epublish
Place of Publication
Canada
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 24334198
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.2647 [doi]
Output Language
Unknown(0)
PMID
24334198
Abstract
BACKGROUND: Incidence of sexually transmitted infections (STIs) among young people in the United Kingdom is increasing. The Internet can be a suitable medium for delivery of sexual health information and sexual health promotion, given its high usage among young people, its potential for creating a sense of anonymity, and ease of access. Online randomized controlled trials (RCTs) are increasingly being used to evaluate online interventions, but while there are many advantages to online methodologies, they can be associated with a number of problems, including poor engagement with online interventions, poor trial retention, and concerns about the validity of data collected through self-report online. We conducted an online feasibility trial that tested the effects of the Sexunzipped website for sexual health compared to an information-only website. This study reports on a qualitative evaluation of the trial procedures, describing participants' experiences and views of the Sexunzipped online trial including methods of recruitment, incentives, methods of contact, and sexual health outcome measurement. OBJECTIVE: Our goal was to determine participants' views of the acceptability and validity of the online trial methodology used in the pilot RCT of the Sexunzipped intervention. METHODS: We used three qualitative data sources to assess the acceptability and validity of the online pilot RCT methodology: (1) individual interviews with 22 participants from the pilot RCT, (2) 133 emails received by the trial coordinator from trial participants, and (3) 217 free-text comments from the baseline and follow-up questionnaires. Interviews were audio-recorded and transcribed verbatim. An iterative, thematic analysis of all three data sources was conducted to identify common themes related to the acceptability and feasibility of the online trial methodology. RESULTS: Interview participants found the trial design, including online recruitment via Facebook, online registration, email communication with the researchers, and online completion of sexual health questionnaires to be highly acceptable and preferable to traditional methods. Incentives might assist in recruiting those who would not otherwise participate. Participants generally enjoyed taking part in sexual health research online and found the questionnaire itself thought-provoking. Completing the sexual health questionnaires online encouraged honesty in responding that might not be achieved with other methods. The majority of interview participants also thought that receiving and returning a urine sample for chlamydia testing via post was acceptable. CONCLUSIONS: These findings provide strong support for the use of online research methods for sexual health research, emphasizing the importance of careful planning and execution of all trial procedures including recruitment, respondent validation, trial related communication, and methods to maximize follow-up. Our findings suggest that sexual health outcome measurement might encourage reflection on current behavior, sometimes leading to behavior change. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number (ISRCTN): 55651027; http://www.controlled-trials.com/isrctn/pf/55651027 (Archived by WebCite at http://www.webcitation.org/6LbkxdPKf).
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Links
Book Title
Database
Publisher
Data Source
Authors
Nicholas,A., Bailey,J.V., Stevenson,F., Murray,E.
Original/Translated Title
URL
Date of Electronic
20131212
PMCID
PMC3868966
Editors
Biomarkers in neuroendocrine tumors 2013 Division of Hematology Oncology, Tufts Cancer Center. Boston, MA 02111, USA. dr.marvin.duque@hotmail.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
JOP : Journal of the pancreas
Periodical, Abbrev.
JOP
Pub Date Free Form
10-Jul
Volume
14
Issue
4
Start Page
372
Other Pages
376
Notes
LR: 20151119; JID: 101091810; 0 (Biomarkers, Tumor); 0 (Chromogranin A); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.10.1 (Receptor, IGF Type 1); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); 2013/06/
Place of Publication
Italy
ISSN/ISBN
1590-8577; 1590-8577
Accession Number
PMID: 23846930
Language
eng
SubFile
Journal Article; IM
DOI
10.6092/1590-8577/1692 [doi]
Output Language
Unknown(0)
PMID
23846930
Abstract
Neuroendocrine tumors are a heterogeneous group of tumors with cells of neuroendocrine differentiation that arise from diverse anatomic sites with varying morphologic and clinical features. Since the natural history and prognosis varies widely between individual neuroendocrine tumor types, there is a critical need to identify accurate prognostic and predictive biomarkers and markers predictive of therapeutic efficacy. To date, plasma chromogranin-A levels have generally been accepted as the most useful biomarker, despite the fact that there are substantial concerns in sensitivity and discrepancies in measurement techniques. As a consequence, considerable attention has been focused upon the development of novel biomarkers that can be utilized with more clinical efficacy than chromogranin-A. In addition to amplifying the diagnostic/prognostic landscape, the need to calibrate the efficacy of biological targeted therapy has further accelerated the development of molecular biomarkers. At the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, Chou et al. (Abstract #e15151) presented data that chromogranin A levels can be monitored during treatment to predict clinical outcome. Modlin et al. (Abstract #4137), demonstrated a promising novel biomarker, serum multi-transcript molecular signature. Grande et al. (Abstract #4140), Heetfield et al. (Abstract #e15071) and Casanovas et al. (Abstract #4139) described sVEGFR2, p-mTOR and IGF1R as molecular markers with potential for use in targeted therapy trials. The authors review and summarize these abstracts in this article.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Duque,M., Modlin,I.M., Gupta,A., Saif,M.W.
Original/Translated Title
URL
Date of Electronic
20130710
PMCID
Editors
3-Isopropyl-1-{2-[(1-methyl-1H-tetra-zol-5-yl)sulfan-yl]acet-yl}-2,6-di-phenyl-pi peridin-4-one hemihydrate 2013 Research Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhinganallur, Chennai 600 119, India ; Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India.; Centre of Advanced Study in Crystallography and Biophysics,
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
2-Oct
Volume
69
Issue
Pt 11
Start Page
o1598
Other Pages
Notes
LR: 20140127; JID: 101089178; OID: NLM: PMC3884276; 2013/11/01 [ecollection]; 2013/09/04 [received]; 2013/09/25 [accepted]; 2013/10/02 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 24454052
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536813026500 [doi]
Output Language
Unknown(0)
PMID
24454052
Abstract
In the title compound, C24H27N5O2S.0.5H2O, the piperidine ring adopts a distorted boat conformation. The phenyl rings subtend dihedral angles of 69.7 (1) and 88.7 (1) degrees with the best plane through the piperidine moiety. In the crystal, symmetry-related mol-ecules are linked through a network of C-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredN inter-actions, the former connecting them into zigzag chains along the c-axis direction and the latter forming an R (2) 2(4)motif. The dimer formation (C-Hcdots, three dots, centeredN) and the repetition of symmetry-related molecules (C-Hcdots, three dots, centeredO) along the b-axis direction stabilize the packing mode. The water mol-ecule is located on a twofold rotation axis.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Ganesan,S., Sugumar,P., Ananthan,S., Ponnuswamy,M.N.
Original/Translated Title
URL
Date of Electronic
20131002
PMCID
PMC3884276
Editors
Environmental tobacco smoke exposure at home and smoking prevalence in the general Portuguese population--the INAsma study 2013 Servico de Imunoalergologia, Centro Hospitalar Sao Joao, Porto, Portugal. ambrpereira@gmail.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Revista portuguesa de pneumologia
Periodical, Abbrev.
Rev.Port.Pneumol.
Pub Date Free Form
May-Jun
Volume
19
Issue
3
Start Page
114
Other Pages
124
Notes
LR: 20150408; CI: Copyright (c) 2012; JID: 9813736; 0 (Tobacco Smoke Pollution); 2012/01/17 [received]; 2012/12/29 [revised]; 2013/01/03 [accepted]; 2013/05/08 [aheadofprint]; ppublish
Place of Publication
Portugal
ISSN/ISBN
2172-6825; 0873-2159
Accession Number
PMID: 23664023
Language
eng; por
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.rppneu.2013.01.002 [doi]
Output Language
Unknown(0)
PMID
23664023
Abstract
BACKGROUND: We aimed to: 1) estimate the prevalence of exposure to environmental tobacco smoke (ETS) at home in the Portuguese population; 2) estimate tobacco smoking prevalence in Portugal; 3) identify social and personal characteristics associated with smoking or exposure to ETS. METHODS: Nationwide, cross-sectional, population-based telephone survey. Overall, 6003 individuals completed the interview. ETS exposure at home was defined as exposure to at least one current smoker at home. A smoker was defined as someone with 15 years or older, smoking at least 1 cigarette per day during a year; a current smoker (CS) smoked in the last month. RESULTS: Exposure to ETS at home was reported by 26.6% (95%CI 25.5-27.7) of the participants. Living in households with >/=4 persons (OR=2.31; 95%CI[1.81-2.96]), being a current smoker (OR=7.29; 95%CI[5.74-9.26]) or having current asthma (OR=2.06; 95%CI[1.45-2.94]) were factors positively associated with ETS exposure. When analyzed by gender, the effect of current asthma was only relevant to females. Currently 19.0% (95%CI 18.0-20.0) of the Portuguese population smokes tobacco and 17.2% (95%CI 16.2-18.2) are ex-smokers. CS prevalence is higher in males than females (26.5%versus 12.2%, p
Descriptors
Links
Book Title
Database
Publisher
Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana
Data Source
Authors
Pereira,A.M., Morais-Almeida,M., Sa e Sousa,A., Jacinto,T., Azevedo,L.F., Robalo Cordeiro,C., Bugalho de Almeida,A., Fonseca,J.A.
Original/Translated Title
URL
Date of Electronic
20130508
PMCID
Editors
Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome 2013 Nicola de Bortoli, Irene Martinucci, Massimo Bellini, Santino Marchi, Division of Gastroenterology, University of Pisa, 56124 Pisa, Italy.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
World journal of gastroenterology
Periodical, Abbrev.
World J.Gastroenterol.
Pub Date Free Form
21-Sep
Volume
19
Issue
35
Start Page
5787
Other Pages
5797
Notes
LR: 20151022; JID: 100883448; OID: NLM: PMC3793133; OTO: NOTNLM; 2012/09/24 [received]; 2012/11/14 [revised]; 2012/12/25 [accepted]; ppublish
Place of Publication
China
ISSN/ISBN
2219-2840; 1007-9327
Accession Number
PMID: 24124323
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.3748/wjg.v19.i35.5787 [doi]
Output Language
Unknown(0)
PMID
24124323
Abstract
Several studies indicate a significant degree of overlap between irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Likewise, both functional heartburn (FH) and IBS are functional digestive disorders that may occur in the same patients. However, data establishing a solid link between FH and IBS are lacking, mainly because the clinical definition of FH has undergone substantial changes over the years. The available literature on the overlap between GERD or FH and IBS highlights considerable heterogeneity in terms of the criteria and diagnostic procedures used to assess heartburn and IBS. In particular, several epidemiological studies included patients with concomitant IBS and GERD without any attempt to distinguish FH (as defined by the Rome III criteria) from GERD via pathophysiological investigations. Independent of these critical issues, there is preliminary evidence supporting a significant degree of FH-IBS overlap. This underscores the need for studies based on updated diagnostic criteria and accurate pathophysiological classifications, particularly to distinguish FH from GERD. This distinction would represent an essential starting point to achieving a better understanding of pathophysiology in the subclasses of patients with GERD and FH and properly assessing the different degrees of overlap between IBS and the subcategories of heartburn.The present review article intends to appraise and critically discuss current evidence supporting a possible concomitance of GERD or FH with IBS in the same patients and to highlight the pathophysiological relationships between these disorders.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
de Bortoli,N., Martinucci,I., Bellini,M., Savarino,E., Savarino,V., Blandizzi,C., Marchi,S.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC3793133
Editors
Opium: an emerging risk factor for gastric adenocarcinoma 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Int J Cancer
Periodical, Abbrev.
Int.J.Cancer
Pub Date Free Form
Volume
133
Issue
2
Start Page
455
Other Pages
61
Notes
ID: 23319416
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Opium use has been associated with higher risk of cancers of the esophagus, bladder, larynx, and lung; however, no previous study has examined its association with gastric cancer. There is also little information on the associations between hookah (water pipe) smoking or the chewing of tobacco products and the risk of gastric cancer. In a case-control study in Golestan Province of Iran, we enrolled 309 cases of gastric adenocarcinoma (118 noncardia, 161 cardia and 30 mixed-location adenocarcinomas) and 613 matched controls. Detailed information on long-term use of opium, tobacco products and other covariates were collected using structured and validated lifestyle and food frequency questionnaires. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were obtained using conditional logistic regression models. Opium use was associated with an increased risk of gastric adenocarcinoma, with an adjusted OR (95% CI) of 3.1 (1.9-5.1), and this increased risk was apparent for both anatomic subsites (cardia and noncardia). There was a dose-response effect, and individuals with the highest cumulative opium use had the strongest association (OR: 4.5; 95% CI: 2.3-8.5). We did not find a statistically significant association between the use of any of the tobacco products and risk of gastric adenocarcinoma, overall or by anatomic subsite. We showed, for the first time, an association between opium use and gastric adenocarcinoma. Given that opium use is a traditional practice in many parts of the world, these results are of public health significance.
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Shakeri,Ramin, Malekzadeh,Reza, Etemadi,Arash, Nasrollahzadeh,Dariush, Aghcheli,Karim, Sotoudeh,Masoud, Islami,Farhad, Pourshams,Akram, Pawlita,Michael, Boffetta,Paolo, Dawsey,Sanford M., Abnet,Christian C., Kamangar,Farin
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Waterpipe smoking among U.S. university students 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine Tob Res
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Volume
15
Issue
1
Start Page
29
Other Pages
35
Notes
ID: 22641433
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
INTRODUCTION: While cigarette use is declining, smoking tobacco with a waterpipe is an emerging trend. We aimed to determine the prevalence of waterpipe use in a large diverse sample of U.S. university students and to assess the association of waterpipe use with individual and institution-related characteristics. METHODS: We assessed students from 152 U.S. universities participating in the National College Health Assessment during 2008-2009. We used multivariable regression models to determine independent associations between individual and institutional characteristics and waterpipe tobacco use in the past 30 days and ever. RESULTS: Of 105,012 respondents included in the analysis, most were female (65.7%), White (71.2%), and attending public (59.7%) nonreligious (83.1%) institutions. Mean age was 22.1 years. A total of 32,013 (30.5%) reported ever using a waterpipe to smoke tobacco. Rates for current tobacco use were 8.4% for waterpipes, 16.8% for cigarettes, 7.4% for cigars (including cigarillos), and 3.5% for smokeless tobacco. Of current waterpipe users, 51.4% were not current cigarette smokers. Although current waterpipe use was reported across all individual and institutional characteristics, fully adjusted multivariable models showed that it was most strongly associated with younger age, male gender, White race, fraternity/sorority membership, and nonreligious institutions in large cities in the western United States. CONCLUSIONS: After cigarettes, waterpipe use was the most common form of tobacco use among university students. Because waterpipe use affects groups with a wide variety of individual and institutional characteristics, it should be included with other forms of tobacco in efforts related to tobacco surveillance and intervention.
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Primack,Brian A., Shensa,Ariel, Kim,Kevin H., Carroll,Mary V., Hoban,Mary T., Leino,E V., Eissenberg,Thomas, Dachille,Kathleen H., Fine,Michael J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Smoking trajectories across high school: sensation seeking and Hookah use 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine Tob Res
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Volume
15
Issue
8
Start Page
1400
Other Pages
8
Notes
ID: 23322766
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
INTRODUCTION: This study investigated the associations of trajectories of cigarette smoking over the high school years with the prior development of childhood sensation seeking and the subsequent use of cigarettes and hookah at age 20/21. METHODS: Participants (N = 963) were members of a cohort-sequential longitudinal study, the Oregon Youth Substance Use Project. Sensation seeking was assessed across 4th-8th grades and cigarette smoking was assessed across 9th-12th grades. Cigarette and hookah use was assessed at age 20/21 for 684 of the 963 participants. RESULTS: Four trajectory classes were identified: Stable High Smokers (6%), Rapid Escalators (8%), Experimenters (15%), and Stable Nonsmokers or very occasional smokers (71%). Membership in any smoker class versus nonsmokers was predicted by initial level and growth of sensation seeking. At age 20/21, there was a positive association between smoking and hookah use for Nonsmokers and Experimenters in high school, whereas this association was not significant for Stable High Smokers or Rapid Escalators. CONCLUSIONS: Level and rate of growth of sensation seeking are risk factors for adolescent smoking during high school (Stable High Smokers, Rapid Escalators, and Experimenters), suggesting the need for interventions to reduce the rate of increase in childhood sensation seeking. For those who were not already established smokers by the end of high school, hookah use may have served as a gateway to smoking.
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Hampson,Sarah E., Tildesley,Elizabeth, Andrews,Judy A., Barckley,Maureen, Peterson,Missy
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Gender differences in patterns and correlates of khat and tobacco use 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine Tob Res
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Volume
15
Issue
6
Start Page
1130
Other Pages
5
Notes
ID: 23197767
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
INTRODUCTION: Although research suggests gender differences in patterns of tobacco use, whether gender moderates concurrent use of tobacco and other substances remains unclear. In some parts of Africa and the Middle East, tobacco is often accompanied with khat (Catha edulis), a widely used substance in these regions. The concurrent use of tobacco and khat may represent a public health burden spreading to other countries in Europe and North America. METHOD: A total of 189 participants (69 women) khat users and smokers in Yemen were asked to complete questionnaires that focused on patterns of khat and tobacco use. Chi-square tests, analyses of variance, and correlational analyses were conducted. RESULTS: Reported frequency and intensity of khat and tobacco use were greater among men than in women. Also, reported number of cigarettes smoked during a khat session was higher among men than among women, whereas frequency of waterpipe use during the session was greater among women than among men. Smoking status (daily or occasional) was positively associated with khat use in women only. Age of onset of khat use was inversely related to the number of cigarettes smoked during a khat session and with intensity of khat chewing. The majority of participants reported that they had thought about and have attempted to quit khat and tobacco use. CONCLUSIONS: The results provide evidence for gender differences in patterns of concurrent use of tobacco and khat. Identifying determinants of tobacco and khat use may be useful in reducing the risk of their negative health outcomes.
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Nakajima,Motohiro, al'Absi, Mustafa, Dokam,Anisa, Alsoofi,Mohammed, Khalil,Najat Sayem, Al Habori, Molham
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
A comparison of cigarette- and hookah-related videos on YouTube 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tob Control
Periodical, Abbrev.
Tob.Control
Pub Date Free Form
Volume
22
Issue
5
Start Page
319
Other Pages
23
Notes
ID: 22363069
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
OBJECTIVE: YouTube is now the second most visited site on the internet. The authors aimed to compare characteristics of and messages conveyed by cigarette- and hookah-related videos on YouTube. METHODS: Systematic search procedures yielded 66 cigarette-related and 61 hookah-related videos. After three trained qualitative researchers used an iterative approach to develop and refine definitions for the coding of variables, two of them independently coded each video for content including positive and negative associations with smoking and major content type. RESULTS: Median view counts were 606,884 for cigarettes-related videos and 102,307 for hookah-related videos (p
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Carroll,Mary V., Shensa,Ariel, Primack,Brian A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors