WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans	2010	Unite Biologie et Pathogenicite Fongiques, Institut Pasteur, Paris, France.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form May Volume 54 Issue 5 Start Page 2096 Other Pages 2111 Notes LR: 20141204; JID: 0315061; 0 (ALS3 protein, Candida albicans); 0 (Antifungal Agents); 0 (Echinocandins); 0 (Extracellular Matrix Proteins); 0 (Fungal Proteins); 0 (HWP1 protein, Candida albicans); 0 (Membrane Glycoproteins); 0 (beta-Glucans); 7XU7A7DROE Place of Publication United States ISSN/ISBN 1098-6596; 0066-4804 Accession Number PMID: 20194705 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1128/AAC.01638-09 [doi] Output Language Unknown(0) PMID 20194705 Abstract Candida albicans can form biofilms that exhibit elevated intrinsic resistance to various antifungal agents, in particular azoles and polyenes. The molecular mechanisms involved in the antifungal resistance of biofilms remain poorly understood. We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. Mature C. albicans biofilms grown under continuous flow were exposed for as long as 2 h to concentrations of fluconazole (FLU), amphotericin B (AMB), and caspofungin (CAS) that, while lethal for planktonic cells, were not lethal for biofilms. Interestingly, FLU-exposed biofilms showed no significant changes in gene expression over the course of the experiment. In AMB-exposed biofilms, 2.7% of the genes showed altered expression, while in CAS-exposed biofilms, 13.0% of the genes had their expression modified. In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. There was little overlap between AMB- or CAS-responsive genes in biofilms and those that have been identified as AMB, FLU, or CAS responsive in C. albicans planktonic cultures. These results suggested that the resistance of C. albicans biofilms to azoles or polyenes was due not to the activation of specific mechanisms in response to exposure to these antifungals but rather to the intrinsic properties of the mature biofilms. In this regard, our study led us to observe that AMB physically bound C. albicans biofilms and beta-glucans, which have been proposed to be major constituents of the biofilm extracellular matrix and to prevent azoles from reaching biofilm cells. Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. Descriptors Amphotericin B/metabolism/pharmacology, Antifungal Agents/metabolism/pharmacology, Biofilms/drug effects/growth & development, Candida albicans/drug effects/genetics/growth & development, Drug Resistance, Fungal/physiology, Echinocandins/metabolism/pharmacology, Extracellular Matrix Proteins/metabolism, Fluconazole/metabolism/pharmacology, Fungal Proteins/genetics, Gene Expression Profiling, Gene Expression Regulation, Fungal/drug effects, Luciferases/genetics, Membrane Glycoproteins/genetics, Transcription, Genetic/drug effects, beta-Glucans/metabolism Links Book Title Database Publisher Data Source Authors Vediyappan,G., Rossignol,T., d'Enfert,C. Original/Translated Title URL Date of Electronic 20100301 PMCID PMC2863626 Editors
Quantifying recreational shore angling catch and harvest in southern Portugal (north-east Atlantic Ocean): implications for conservation and integrated fisheries management	2010	Centre of Marine Sciences-Centre of Marine and Environmental Research (CCMAR-CIMAR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. pveiga@ualg.pt	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of fish biology Periodical, Abbrev. J.Fish Biol. Pub Date Free Form Jun Volume 76 Issue 9 Start Page 2216 Other Pages 2237 Notes JID: 0214055; ppublish Place of Publication England ISSN/ISBN 1095-8649; 0022-1112 Accession Number PMID: 20557660 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1111/j.1095-8649.2010.02665.x [doi] Output Language Unknown(0) PMID 20557660 Abstract Recreational shore fishing along 250 km of the south and south-west coast of Portugal was studied based on roving creel and aerial surveys. Surveys were conducted between August 2006 and July 2007, following a stratified random-sampling design and provided information on catch and effort, harvest and discards, angler demographics and fishing habits. Overall, 192 roving creel surveys, 24 aerial surveys and 1321 interviews were conducted. Based on the aerial surveys, a mean +/-s.e. total fishing effort of 705,236 +/- 32,765 angler h year(-1) was estimated, corresponding to 166,430 +/- 9792 fishing trips year(-1). Average time spent per fishing trip was 4.7 h. A total of 48 species, belonging to 22 families, were recorded in roving creel surveys. The most important species was Diplodus sargus, accounting for 44% of the total catches by number and 48% by mass. Estimated mean +/-s.e. total annual recreational shore fishing catch was 160.2 +/- 12.6 t year(-1) (788,049 +/- 54,079 fishes year(-1)), of which 147.4 +/- 11.9 t year(-1) (589,132 +/- 42,360 fishes year(-1)) was retained. Although overall shore-based recreational catches only corresponded to 0.8% of the commercial landings (only common species considered), D. sargus catches by recreational shore anglers were considerable, corresponding to 65% of the commercial landings. The implications of these results for integrated fisheries management and conservation are discussed, and future research proposed. Descriptors Animals, Atlantic Ocean, Conservation of Natural Resources, Environmental Monitoring/methods, Fisheries/statistics & numerical data, Fishes/classification, Population Density, Portugal, Recreation Links Book Title Database Publisher Data Source Authors Veiga,P., Ribeiro,J., Goncalves,J. M., Erzini,K. Original/Translated Title URL Date of Electronic PMCID Editors
Is domestic tap water a risk for infections in neutropenic patients?	2010	Section Infection Control and Hospital Epidemiology, Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Steinhoevelstr. 9, 89075, Ulm, Germany. heike.von-baum@uniklinik-ulm.de	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Infection Periodical, Abbrev. Infection Pub Date Free Form Jun Volume 38 Issue 3 Start Page 181 Other Pages 186 Notes LR: 20111117; JID: 0365307; 2009/09/09 [received]; 2010/01/12 [accepted]; 2010/03/18 [aheadofprint]; ppublish Place of Publication Germany ISSN/ISBN 1439-0973; 0300-8126 Accession Number PMID: 20237946 Language eng SubFile Journal Article; IM DOI 10.1007/s15010-010-0005-4 [doi] Output Language Unknown(0) PMID 20237946 Abstract BACKGROUND: Home care has become popular in the management of hemato-oncologic patients. Therefore, we conducted a prospective study to assess whether tap water from the domestic environment of neutropenic patients poses a risk for infections from the waterborne pathogens nontuberculous mycobacteria (NTM), Legionella spp., and Pseudomonas aeruginosa. MATERIALS AND METHODS: Tap water samples were taken in the homes of 65 hemato-oncologic patients who were discharged from the hospital whilst neutropenic and had a suspected period of neutropenia of a minimum of 10 days. Selective culture for Legionella, P. aeruginosa, and NTM was performed. Patients who required hospital readmission were monitored for infection with the aforementioned pathogens over the following 3 months. RESULTS: NTM were cultured in 62 (95.4%) households in concentrations from 1 to 1,000 CFU/500 ml. The facultative pathogenic species Mycobacterium chelonae (58.5% of taps) and M. mucogenicum (38.5% of taps) were most frequently detected. Legionella spp. was cultured from six households (9.2%), including five households with L. pneumophila in concentrations from 25 to 2,500 CFU/500 ml. P. aeruginosa was found in seven households (10.8%) in concentrations from 5 to 2,500 CFU/500 ml. While clinical infection with Legionella spp. was not detected in any patients, infection with M. chelonae and P. aeruginosa occurred in one and seven patients, respectively. However, transmission from household water could not be confirmed. CONCLUSION: Although the risk of infection from household water-borne pathogens appears low, preventive measures may be considered on an individual basis in patients with long-term immunosuppression as well as in patients with long-term central-vascular catheterization. Descriptors Colony Count, Microbial, Community-Acquired Infections/microbiology, Electrophoresis, Gel, Pulsed-Field, Gram-Negative Bacterial Infections/microbiology, Humans, Legionella/isolation & purification, Leukemia/microbiology, Lymphoma/microbiology, Mycobacterium Infections, Nontuberculous/microbiology, Mycobacterium chelonae/isolation & purification, Neutropenia/epidemiology/microbiology, Prevalence, Prospective Studies, Pseudomonas aeruginosa/isolation & purification, Water Microbiology, Water Supply/analysis Links Book Title Database Publisher Data Source Authors von Baum,H., Bommer,M., Forke,A., Holz,J., Frenz,P., Wellinghausen,N. Original/Translated Title URL Date of Electronic 20100318 PMCID Editors
Risk perceptions of menthol cigarettes compared with nonmenthol cigarettes among New Jersey adults	2010	Center for Tobacco Surveillance and Evaluation Research, School of Public Health, University of Medicine and Dentistry of New Jersey, 335 George Street, Suite 2100, New Brunswick, NJ 08903, USA. olivia.wackowski@umdnj.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Jul Volume 12 Issue 7 Start Page 786 Other Pages 790 Notes LR: 20151119; JID: 9815751; 0 (Flavoring Agents); 1490-04-6 (Menthol); 2010/06/03 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 20522521 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1093/ntr/ntq085 [doi] Output Language Unknown(0) PMID 20522521 Abstract INTRODUCTION: Menthol cigarettes were historically marketed as "healthier" cigarettes, and menthol possesses cooling qualities that may reduce the perceived harshness of cigarette smoke. As such, it is possible that smokers may perceive menthol cigarettes to be safer when, in fact, some research suggests that menthols may be more addictive than regular cigarettes. Research shows that smokers have a faulty understanding of the risks of cigarettes in general, but little is known about smokers' risk perceptions for these particular products. METHODS: We examined data from the 2005 New Jersey Adult Tobacco Survey, a statewide random-digit-dial telephone survey monitoring tobacco-use behavior, knowledge, and attitudes and which asked participants to compare how risky (somewhat less risky, about the same, or somewhat more risky) menthol cigarettes were with nonmenthol cigarettes. RESULTS: Few menthol smokers (2.4%) and survey respondents overall (4.0%) believed menthol cigarettes to be less risky than nonmenthol cigarettes. In contrast, 30.2% of menthol smokers and 25.9% of all respondents (including nonsmokers) believed menthols to be more risky than nonmenthol cigarettes. Compared with never-smokers, nonmenthol smokers were most likely to believe this (AOR = 4.51), followed by former smokers (AOR = 1.77) and current menthol smokers (AOR = 1.58). Among current smokers, Blacks (AOR = 2.17) were more likely than Whites to indicate menthols as being more risky and young adults (18- to 24-year-olds) were the age group most likely to hold this belief (AOR = 3.30). CONCLUSIONS: Future research should explore whether these perceptions exist in broader population groups as well as their development and association with smoking-related behaviors. Descriptors Adult, Attitude to Health/ethnology, Behavior, Addictive/epidemiology/ethnology, Ethnic Groups/statistics & numerical data, Female, Flavoring Agents/administration & dosage, Humans, Male, Menthol/administration & dosage, Middle Aged, New Jersey/epidemiology, Smoking/epidemiology/ethnology, Smoking Cessation/ethnology, Social Perception, Surveys and Questionnaires, Tobacco Use Disorder/epidemiology, Young Adult Links Book Title Database Publisher Data Source Authors Wackowski,O. A., Delnevo,C. D., Lewis,M. J. Original/Translated Title URL Date of Electronic 20100603 PMCID Editors
(2S)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hy-droxy-phen-yl)acetic acid	2010	Department of Chemistry, Shandong Normal University, Jinan 250014, People's Republic of China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 3-Jul Volume 66 Issue Pt 8 Start Page o1907 Other Pages 8 Notes LR: 20111209; JID: 101089178; OID: NLM: PMC3007271; 2010/05/31 [received]; 2010/06/28 [accepted]; 2010/07/03 [epublish]; epublish Place of Publication England ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 21588240 Language eng SubFile Journal Article DOI 10.1107/S1600536810025262 [doi] Output Language Unknown(0) PMID 21588240 Abstract There are two mol-ecules in the asymmetric unit of the title compound, C(15)H(17)N(3)O(6). The 2,3-dioxopiperazine ring adopts a half-chair conformation with torsion angles of -7.6 (4) and 35.1 (4) degrees in one mol-ecule, and 5.3 (4) and 45.4 (4) degrees in the other mol-ecule. In the crystal structure, the carb-oxy groups are involved in classical inversion-related O-Hcdots, three dots, centeredO hydrogen bonds, which link the mol-ecules into centrosymmetric dimers. These dimers are further linked by inter-molecular O-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds. Each independent mol-ecule also exhibits an intra-molecular N-Hcdots, three dots, centeredO hydrogen bond. The H atoms of the carb-oxy groups are disordered over two positions, with refined site-occupancy factors of 0.5. Descriptors Links Book Title Database Publisher Data Source Authors Wang,Q., Hu,L., Ma,J. P., Guo,D. S. Original/Translated Title URL Date of Electronic 20100703 PMCID PMC3007271 Editors
Determination of polycyclic aromatic hydrocarbons in water by a novel mesoporous-coated stainless steel wire microextraction combined with HPLC	2010	College of Chemistry and Chemical Engineering, Northwest Normal University, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, Lanzhou, PR China. wxm98@163.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of separation science Periodical, Abbrev. J.Sep.Sci. Pub Date Free Form Oct Volume 33 Issue 20 Start Page 3239 Other Pages 3244 Notes LR: 20131121; JID: 101088554; 0 (Polycyclic Hydrocarbons, Aromatic); 059QF0KO0R (Water); 12597-68-1 (Stainless Steel); ppublish Place of Publication Germany ISSN/ISBN 1615-9314; 1615-9306 Accession Number PMID: 20839236 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1002/jssc.201000287 [doi] Output Language Unknown(0) PMID 20839236 Abstract A novel mesoporous-coated stainless steel wire microextraction coupled with the HPLC procedure for quantification of four polycyclic aromatic hydrocarbons in water has been developed, based on the sorption of target analytes on a selectively adsorptive fiber and subsequent desorption of analytes directly into HPLC. Phenyl-functionalized mesoporous materials (Ph-SBA-15) were synthesized and coated on the surfaces of a stainless steel wire. Due to the high porosity and large surface area of the Ph-SBA-15, high extraction efficiency is expected. The influence of various parameters on polycyclic aromatic hydrocarbons extraction efficiency were thoroughly studied and optimized (such as the extraction temperature, the extraction time, the desorption time, the stirring rate and the ionic strength of samples). The results showed that each compound for the analysis of real water samples was tested under optimal conditions with the linearity ranging from 1.02x10(-3) to 200 mug/ L and the detection limits were found from 0.32 to 2.44 ng/ L, respectively. The RSD of the new method was smaller than 4.10%. Descriptors Chromatography, High Pressure Liquid/economics, Polycyclic Hydrocarbons, Aromatic/analysis, Stainless Steel/chemistry, Time Factors, Water/chemistry Links Book Title Database Publisher Data Source Authors Wang,X. M., Du,X. Z., Rao,H. H., Lu,X. Q. Original/Translated Title URL Date of Electronic PMCID Editors
Flow injection solid-phase extraction using multi-walled carbon nanotubes packed micro-column for the determination of polycyclic aromatic hydrocarbons in water by gas chromatography-mass spectrometry	2010	Department of Chemistry, Xuzhou Normal University, Shanghai Road, Xuzhou 221116, China. wuhong1968@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.A Periodical, Abbrev. J.Chromatogr.A Pub Date Free Form 23-Apr Volume 1217 Issue 17 Start Page 2911 Other Pages 2917 Notes CI: Copyright 2010; JID: 9318488; 0 (Nanotubes, Carbon); 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Water Pollutants, Chemical); 2009/08/03 [received]; 2010/01/05 [revised]; 2010/02/19 [accepted]; 2010/02/25 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-3778; 0021-9673 Accession Number PMID: 20236647 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.chroma.2010.02.040 [doi] Output Language Unknown(0) PMID 20236647 Abstract A flow injection solid-phase extraction preconcentration system using a multi-walled carbon nanotubes (MWCNTs) packed micro-column was developed for the determination of 16 polycyclic aromatic hydrocarbons (PAHs) in water by gas chromatography-mass spectrometry (GC-MS). The preconcentration of PAHs on the MWCNTs was carried out based on the adsorption retention of analytes by on-line introducing the sample into the micro-column system. Methanol was introduced to elute the retained analytes for GC-MS analysis using selected ion monitoring (SIM) mode. Important influence factors were studied in detail, such as sample acidity, sample flow rate, eluent flow rate and volume, dimensions of MWCNTs and amounts of packing material. Limits of detection of 16 PAHs for an extraction of 50 mL water sample were in the range of 0.001-0.15 microg L(-1), and the precisions (RSD) were in the range of 4-14%. The optimized method was successfully applied to the determination of 16 PAHs in surface waters, with recoveries in the range of 72-93% for real spiked sample. Descriptors Gas Chromatography-Mass Spectrometry/methods, Nanotubes, Carbon/chemistry, Polycyclic Hydrocarbons, Aromatic/analysis, Solid Phase Extraction/instrumentation/methods, Water Pollutants, Chemical/analysis Links Book Title Database Publisher Elsevier B.V Data Source Authors Wu,H., Wang,X., Liu,B., Lu,J., Du,B., Zhang,L., Ji,J., Yue,Q., Han,B. Original/Translated Title URL Date of Electronic 20100225 PMCID Editors
Determination of the migration of bisphenol diglycidyl ethers from food contact materials by high performance chromatography-tandem mass spectrometry coupled with multi-walled carbon nanotubes solid phase extraction	2010	Hunan Academy of Inspection and Quarantine, Technology Center of Hunan Entry-Exit Inspection and Quarantine Bureau, Hunan Key Laboratory of Food Safety Science & Technology, Changsha 410004, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Se pu = Chinese journal of chromatography / Zhongguo hua xue hui Periodical, Abbrev. Se Pu Pub Date Free Form Nov Volume 28 Issue 11 Start Page 1094 Other Pages 1098 Notes LR: 20131121; JID: 9424804; 0 (Benzhydryl Compounds); 0 (Epoxy Compounds); 0 (Nanotubes, Carbon); F3XRM1NX4H (2,2-bis(4-glycidyloxyphenyl)propane); ppublish Place of Publication China ISSN/ISBN 1000-8713; 1000-8713 Accession Number PMID: 21381429 Language chi SubFile English Abstract; Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 21381429 Abstract A comprehensive analytical method based on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed for measuring 6 exogenous endocrine disruptors--bisphenol diglycidyl ethers, including bisphenol A diglycidyl ether (BADGE), bisphenol A glycidyl (2,3-dihydroxypropyl) ether (BADGE x H2O), bisphenol A glycidyl (3-chloro-2-hydroxypropyl) ether ( BADGE x HCl), bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether (BADGE x H2O x HCl), bisphenol F diglycidyl ether (BFDGE) and bisphenol F bis (3-chloro-2-hydroxypropyl) ether (BFDGE x 2HCl). The samples were extracted with methyl tert-butyl ether (MTBE) by ultrasonic wave assistant extraction. The extracts were cleaned up and concentrated on multi-walled carbon nanotubes (MWCNTs). The target compounds were analyzed by HPLC-MS/MS under positive ion mode using a COSMOSIL C18 column as analytical column. Under the optimal conditions, the calibration curves showed a good linearity in the concentration range of 1.0-100.0 microg/L for 6 target compounds. The correlation coefficients (r2) were higher than 0.999 1. Recoveries of 6 analytes at three spiked levels ranged from 78.6% to 89.9%, with relative standard deviations (RSDs) less than 10%. The detection limits of the method ranged from 0.5 to 1.5 microg/L. The method is sensitive and simple, and is suitable for the rapid determination of the migration of bisphenol diglycidyl ethers from food contact materials. Descriptors Benzhydryl Compounds, Chromatography, High Pressure Liquid/methods, Epoxy Compounds/analysis, Food Contamination/analysis, Food Packaging, Humans, Nanotubes, Carbon, Solid Phase Extraction/methods, Tandem Mass Spectrometry/methods Links Book Title Database Publisher Data Source Authors Wu,X., Ding,L., Li,Z., Zhang,Y., Liu,X., Wang,L. Original/Translated Title URL Date of Electronic PMCID Editors
Generation of resistance to amphotericin B and caspofungin in Candida spp.: experimental study	2009		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chemotherapy (Florence, Italy) Periodical, Abbrev. J.Chemother. Pub Date Free Form Aug Volume 21 Issue 4 Start Page 467 Other Pages 469 Notes LR: 20131121; JID: 8907348; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); F0XDI6ZL63 (caspofungin); ppublish Place of Publication Italy ISSN/ISBN 1973-9478; 1120-009X Accession Number PMID: 19622473 Language eng SubFile Letter; IM DOI 10.1179/joc.2009.21.4.467 [doi] Output Language Unknown(0) PMID 19622473 Abstract Descriptors Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Candida/drug effects/growth & development, Dose-Response Relationship, Drug, Drug Resistance, Fungal, Echinocandins/pharmacology, Humans, Microbial Sensitivity Tests Links Book Title Database Publisher Data Source Authors Soler,L., Pastor,E., Rodriguez,J. C., Ruiz,M., Lopez,P., Cremades,R., Royo,G. Original/Translated Title URL Date of Electronic PMCID Editors
Cigarette smoking, nicotine dependence, and motivation for smoking cessation in psychiatric inpatients	2009	Psychiatry Resident, Department of Psychiatry, University of Calgary, Calgary, Alberta.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Canadian journal of psychiatry.Revue canadienne de psychiatrie Periodical, Abbrev. Can.J.Psychiatry Pub Date Free Form Jan Volume 54 Issue 1 Start Page 36 Other Pages 45 Notes LR: 20151119; JID: 7904187; ppublish Place of Publication Canada ISSN/ISBN 0706-7437; 0706-7437 Accession Number PMID: 19175978 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 19175978 Abstract OBJECTIVE: Cigarette smoking is the leading preventable cause of death and disease in Canada, and is disproportionately more frequent among psychiatric patients. Smoking cessation interventions can be successfully implemented with psychiatric patients, yet no Canadian studies have evaluated smoking prevalence, nicotine dependence, and motivation for smoking cessation in psychiatric inpatients. Our study did so to help plan appropriate interventions for these patients. METHOD: All inpatients aged 18 years or older admitted to acute-care psychiatry units at the Foothills Medical Centre in Calgary, Alberta, during a 6-month period completed a survey involving questions from the Canadian Tobacco Use Monitoring Survey, the Fagerstrom Test for Nicotine Dependence (FTND), the Readiness to Quit Ladder, and the Decisional Balance for Cigarette Smoking. Responses were analyzed for correlation with discharge diagnoses, age, and sex. RESULTS: Among the total inpatients (n = 342), 211 (62%) completed the survey. Among those, 55% were current cigarette smokers and 17.5% were former smokers. Nicotine dependence (FTND > or = 6) was reported in 45.2% of smokers. Smoking prevalence and nicotine dependence severity was greatest in the substance use disorders (SUD) and psychotic disorders groups. Current smokers endorsed more negative than positive attributes of smoking. Regarding smoking cessation, 51% of patients were precontemplative, 12.7% contemplative, and 36.2% preparatory or action-oriented, despite few receiving advice to quit. CONCLUSIONS: Cigarette smoking and nicotine dependence are highly prevalent in psychiatric inpatients. However, self-reported motivation for smoking cessation is noteworthy, emphasizing that cessation advice and appropriate follow-up care should be provided to psychiatric inpatients who smoke. Descriptors Adult, Female, Health Promotion, Hospitalization, Humans, Length of Stay/statistics & numerical data, Male, Motivation, Prevalence, Psychotic Disorders/epidemiology/rehabilitation, Smoking/epidemiology/prevention & control, Smoking Cessation/methods/statistics & numerical data, Surveys and Questionnaires, Tobacco Use Disorder/epidemiology/prevention & control Links Book Title Database Publisher Data Source Authors Solty,H., Crockford,D., White,W. D., Currie,S. Original/Translated Title URL Date of Electronic PMCID Editors

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