WTS database

Title	Pub Year Sort ascending	Author	SearchLink
N-{2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]eth-yl}pyridin-2-amine monohydrate	2010	Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 23-Jun Volume 66 Issue Pt 7 Start Page o1727 Other Pages Notes LR: 20111209; JID: 101089178; OID: NLM: PMC3006790; 2010/05/27 [received]; 2010/06/14 [accepted]; 2010/06/23 [epublish]; epublish Place of Publication England ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 21587944 Language eng SubFile Journal Article DOI 10.1107/S1600536810022816 [doi] Output Language Unknown(0) PMID 21587944 Abstract In the title compound, C(18)H(24)N(4)O.H(2)O, the piperizine ring adopts a chair conformation and the dihedral angle between the phenyl and pyridine rings is 39.9 (3) degrees . The comformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are +anti-periplanar. An intra-molecular C-Hcdots, three dots, centeredO inter-action occurs. In the crystal, the water mol-ecule links the mol-ecules into chains through O-Hcdots, three dots, centeredN hydrogen bonds. Weak N-Hcdots, three dots, centeredO, C-Hcdots, three dots, centeredN and C-Hcdots, three dots, centeredO inter-actions further stabilize the crystal structure. Descriptors Links Book Title Database Publisher Data Source Authors Jiang,Q. F., Lu,C. X. Original/Translated Title URL Date of Electronic 20100623 PMCID PMC3006790 Editors
Emerging tobacco products: hookah use among New Jersey youth	2010		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Prev Med Periodical, Abbrev. Prev.Med. Pub Date Free Form Volume 51 Issue 5 Start Page 394 Other Pages 6 Notes ID: 20817023 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract OBJECTIVE: A national surveillance system to track hookah use by adolescents does not exist. A growing body of evidence suggests that high school-aged students are experimenting with this form of tobacco. This study adds to the current literature by providing prevalence estimates and factors associated with hookah use among New Jersey high school students. METHOD: This study explores factors associated with hookah use using 2008 NJYTS data. The 2008 NJYTS was a self-reported, paper-and-pencil, cross-sectional survey of a representative sample of 3010 high school students. RESULTS: 9.7% of NJ high school students are current hookah users. Predictors of hookah use included those who identified as Asian, concurrent tobacco users, perceiving that cigars are safer than cigarettes, or perceiving that smoking looks cool. CONCLUSION: The prevalence of hookah use, higher likelihood of concurrent tobacco use among hookah users, and misperceptions of safety and popularity of hookah among NJ adolescents are cause for concern and action. The development and regular implementation of standardized hookah prevalence questions into our national and state surveillance systems, as well as targeted, state-specific youth education and prevention activities are essential to thwart this growing public health concern. Descriptors Smoking/epidemiology, Adolescent, Adolescent Behavior, Cross-Sectional Studies, Female, Humans, Male, New Jersey/epidemiology, Population Surveillance, Self Report, Smoking/trends Links http://dx.doi.org/10.1016/j.ypmed.2010.08.016 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Jordan,Heather M., Delnevo,Cristine D. Original/Translated Title URL Date of Electronic PMCID Editors
Uniform diet in a diverse society. Revealing new dietary evidence of the Danish Roman Iron Age based on stable isotope analysis	2010	Museum of Copenhagen, DK-1658 Copenhagen, Denmark. marielouise_sj@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Physical Anthropology Periodical, Abbrev. Am.J.Phys.Anthropol. Pub Date Free Form Dec Volume 143 Issue 4 Start Page 523 Other Pages 533 Notes CI: Copyright (c) 2010; JID: 0400654; 0 (Carbon Isotopes); 0 (Collagen Type I); 0 (Nitrogen Isotopes); ppublish Place of Publication United States ISSN/ISBN 1096-8644; 0002-9483 Accession Number PMID: 20564524 Language eng SubFile Historical Article; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1002/ajpa.21346 [doi] Output Language Unknown(0) PMID 20564524 Abstract A systematic dietary investigation during Danish Roman Iron Age (1-375AD) is conducted by analyzing stable isotope ratios of carbon (delta(13) C) and nitrogen (delta(15) N) in the collagen of human and animal bone. The human sample comprises 77 individuals from 10 burial sites. In addition 31 samples of mammals and fish were analyzed from same geographical area. The investigation characterizes the human diet among different social groupings and analyses dietary differences present between sex, age, and site phase groups. Diachronically, the study investigates the Roman influences that had an effect on social structure and subsistence economy in both the Early and Late Period. Geographically the locations are both inland and coastal. The isotopic data indicate extremely uniform diet both between and within population groups from Early and Late Roman periods and the data are consistent throughout the Roman Iron Age. Protein consumption was dominated by terrestrial animals with no differences among social status, age, sex, or time period, while terrestrial plant protein only seems to have contributed little in the diet. Furthermore, the consumption of marine or aquatic resources does not seem to have been important, even among the individuals living next to the coast. Descriptors Adolescent, Adult, Animals, Anthropology, Physical, Archaeology/methods, Bone and Bones/chemistry, Carbon Isotopes/analysis, Cemeteries, Child, Child, Preschool, Collagen Type I/chemistry, Denmark, Diet/history, Female, Fishes, History, Ancient, History, Medieval, Humans, Male, Middle Aged, Nitrogen Isotopes/analysis Links Book Title Database Publisher Wiley-Liss, Inc Data Source Authors Jorkov,M. L., Jorgensen,L., Lynnerup,N. Original/Translated Title URL Date of Electronic PMCID Editors
A rapid situation assessment (RSA) study of alcohol and drug use in Lebanon	2010	Department of Psychiatry and Clinical Psychology, School of Medicine, Balamand University, Lebanon. egkaram@idraac.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Le Journal medical libanais.The Lebanese medical journal Periodical, Abbrev. J.Med.Liban. Pub Date Free Form Apr-Jun Volume 58 Issue 2 Start Page 76 Other Pages 85 Notes JID: 0375352; ppublish Place of Publication Lebanon ISSN/ISBN 0023-9852; 0023-9852 Accession Number PMID: 20549893 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 20549893 Abstract BACKGROUND: Research on substance use and misuse in Lebanon is scarce and, when available, focuses on a specific substance or a limited segment of the population. The objective of this Rapid Situation Assessment (RAS) study was to survey the use of multiple substances in diverse segments of the Lebanese population. METHODS: A multi-method and multi-sample survey was conducted to collect quantitative and qualitative data from the academic sector (high school and university students), substance users in treatment or under arrest (prison, detention), and non-institutionalized "street" users. RESULTS: Age of first use of substances started as early as 9 years in the youth sample. Moreover, 12% of the high school students reported smoking one or more packs of cigarettes per day and 9% of the university students met criteria for DSM-IV alcohol abuse. Cannabis represented the most commonly used illicit drug in both high school and university students, and tranquilizers were the most frequently misused medicinal substance. Heroin was responsible for 50% of the treatment admissions, followed by cocaine (20%), and alcohol (20%); heroin was also the most common substance of arrest. Recidivism was almost the rule for heroin users across all treatment settings. Unperceived need for treatment was the most common reason for not seeking treatment in non-institutionalized drug users (47.6%). Injecting drug use was a common behavior noted within substance using populations, in treatment and non-institutionalized (about 50% of them), with a high rate of needle sharing practices. About half of all patients in treatment had a history of police arrests, and about one-third of those in prison ever received prior treatment for substance use. CONCLUSION: The study points towards a growing trend for substance use problems in early adolescence that warrants close monitoring. Further investigation of these patterns is needed since the Lebanese population might have specific pathways of abuse. There is a need to bring together various health, legislative, and academic stakeholders for a continuous appraisal of data from substance abuse studies as evidenced by the recent, although slow, progress in the fields of legislation and treatment that follow such concerted efforts. Descriptors Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Institutionalization, Lebanon/epidemiology, Male, Prisoners/statistics & numerical data, Sampling Studies, Students/statistics & numerical data, Substance-Related Disorders/epidemiology, Young Adult Links Book Title Database Publisher Data Source Authors Karam,E. G., Ghandour,L. A., Maalouf,W. E., Yamout,K., Salamoun,M. M. Original/Translated Title URL Date of Electronic PMCID Editors
Comparison of two different methods for the investigation of in vitro susceptibilities of planktonic and biofilm forming Candida species to antifungal agents	2010	Gazi Universitesi Eczacilik Fakultesi, Farmasotik Mikrobiyoloji Anabilim Dali, Ankara, Turkiye. fkaynak@gmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Mikrobiyoloji bulteni Periodical, Abbrev. Mikrobiyol.Bul. Pub Date Free Form Oct Volume 44 Issue 4 Start Page 619 Other Pages 631 Notes JID: 7503830; 0 (Antifungal Agents); ppublish Place of Publication Turkey ISSN/ISBN 0374-9096; 0374-9096 Accession Number PMID: 21063974 Language tur SubFile Comparative Study; English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 21063974 Abstract Microdilution method that determines the minimum inhibitory concentrations (MIC) of antifungal agents against Candida spp. is still the only method used in laboratories for both biofilm and planktonic forms. However, it was determined in several studies that there were susceptibility differences between the biofilm and planktonic forms of the same microorganism. The aims of this study were the determination of in vitro susceptibilities of planktonic and biofilm forms of Candida strains against antifungal agents, the comparison of the data obtained from planktonic and biofilm forms and the evaluation of two different methods used for the detection of susceptibilities of biofilm forms. Candida albicans ATCC 10231, Candida parapsilosis ATCC 90028 and Candida krusei ATCC 6258 were used as reference strains together with clinical isolates of one of each C.albicans, C.parapsilosis and Candida tropicalis. Microdilution method was used to determine the susceptibilities of planktonic forms of the strains according to CLSI M27-A3 standards, and MIC values of fluconazole, itraconazole, flucytosine, amphotericin B and nystatin were determined. For the detection of antifungal susceptibilities of Candida spp. biofilm forms, Calgary biofilm method (CBM) and BioTimer assay (BTA) were used, and minimum biofilm eradication concentration (MBEC) and minimum biofilm inhibition concentration (MBIC) values of the same antifungals were determined. The difference between MIC and CBM-MBEC, CBM-MBEC and BTA-MBEC, CBM-MBEC and BTAMBIC values were found statistically significant (p 0.05) for the other antifungal agents. These findings supported that antifungal susceptibilities of biofilm forming Candida strains should also be investigated. However, MBEC and MBIC of the antifungal agents should not always be expected to be higher than the MIC values since the mechanism of action of the specific antifungal agents and the first inoculum concentration of the microorganisms might differ. Descriptors Antifungal Agents/pharmacology, Biofilms/drug effects, Candida/drug effects/physiology, Humans, Microbial Sensitivity Tests/methods, Plankton/drug effects Links Book Title Database Publisher Data Source Authors Kaynak Onurdag,F., Ozgen,S., Abbasoglu,U., Gurcan,I. S. Original/Translated Title Candida turlerinin biyofilm olusturan ve planktonik formlarinin antifungal ajanlara karsi in vitro duyarliliklarinin arastirilmasinda iki farkli yontemin karsilastirilmasi URL Date of Electronic PMCID Editors
Prevalence of dyspepsia and its correlation with demographic factors and lifestyle in shiraz, southern iran	2010		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Middle East J Dig Dis Periodical, Abbrev. Pub Date Free Form Volume 2 Issue 1 Start Page 24 Other Pages 30 Notes ID: 25197509 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract BACKGROUND Dyspepsia is a common disorder that can present many clinical dilemmas in patient management. Although not life-threatening, the symptoms are long-lasting, interfere with daily activities and have a significant impact upon quality of life. The aim of this study was to determine prevalence of dyspepsia and its relationship with demographic and socioeconomic factors, and lifestyle in an apparently healthy population in Shiraz, southern Iran. METHODS In a population-based study, 1978 subjects aged 35 years or older were interviewed from April to September 2004. A questionnaire consisting of demographic factors, lifestyle data and gastrointestinal symptoms was completed for each participant. The validity and reliability of the questionnaire were determined. RESULTS The prevalence of dyspepsia was 29.9%. The dyspeptic patients were classified as having ulcer-like (27.9%), dysmotility-like (26.2%) or unspecified dyspepsia (45.9%). The prevalence was higher in females, water-pipe smokers, NSAIDs users, and in those with psychological distress, recurrent headache, anxiety, nightmares and past history of gastrointestinal disease. Dyspepsia had an inverse relationship with consumption of pickles, fruits and vegetables, and with duration of meal ingestion. Subjects with dyspepsia symptoms were more likely to restrict their diet, take herbal medicine, use over-the-counter drugs, consult with physicians and consume medication advised by their friends. CONCLUSION This study reveals that dyspepsia has a high prevalence in Shiraz, southern Iran and is associated with several demographic factors, lifestyle and health-seeking behavior. Descriptors Links http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154903/?tool=pubmed Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Khademolhosseini,F., Mehrabani,D., Zare,N., Salehi,M., Heydari,St, Beheshti,M., Saberi-Firoozi,M. Original/Translated Title URL Date of Electronic PMCID Editors
Periodontal health in Down syndrome: contributions of mental disability, personal, and professional dental care	2010	Temple University School of Dentistry, Philadelphia, Pennsylvania, USA. akhocht@temple.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry Periodical, Abbrev. Spec.Care Dentist. Pub Date Free Form May-Jun Volume 30 Issue 3 Start Page 118 Other Pages 123 Notes LR: 20111117; GR: DE15012-02/DE/NIDCR NIH HHS/United States; JID: 8103755; ppublish Place of Publication United States ISSN/ISBN 1754-4505; 0275-1879 Accession Number PMID: 20500707 Language eng SubFile Comparative Study; Journal Article; Research Support, N.I.H., Extramural; D DOI 10.1111/j.1754-4505.2010.00134.x [doi] Output Language Unknown(0) PMID 20500707 Abstract Fifty-five dentate patients with Down syndrome (DS) and 74 with mental disability non-Down (MR) were compared to 88 control subjects. Subjects in the MR and Control groups were matched by gender and ethnicity to subjects with DS. All subjects were nonsmokers. Periodontal evaluation included plaque index (PI), gingival index (GI), bleeding on probing (BOP), and clinical periodontal attachment levels. Caries and missing teeth were recorded. Measures of personal dental hygiene and the frequency of professional dental care were also recorded. Most subjects brushed their teeth at least once per day, but did not floss. Both groups with DS and MR had significantly more missing teeth, more BOP, and higher GI and PI levels than the control group. Patients with DS had more attachment loss (AL) than the other two groups (p < .001). Increased AL in patients with DS was not associated with differences in socioeconomic status, personal/professional dental care, or mental disability. Descriptors Adolescent, Adult, African Americans, Aged, Aged, 80 and over, Case-Control Studies, Dental Care for Disabled, Dental Caries/classification, Dental Devices, Home Care, Dental Plaque Index, Down Syndrome/complications/physiopathology, European Continental Ancestry Group, Female, Gingival Hemorrhage/classification, Humans, Income, Institutionalization, Intellectual Disability/complications/physiopathology, Male, Middle Aged, Oral Hygiene, Periodontal Attachment Loss/classification, Periodontal Index, Self Care, Sex Factors, Social Class, Tooth Loss/classification, Toothbrushing, Young Adult Links Book Title Database Publisher Data Source Authors Khocht,A., Janal,M., Turner,B. Original/Translated Title URL Date of Electronic PMCID Editors
Salivary calcium concentration in relation to periodontal health of female tobacco smokers: a pilot study	2010	Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged, Hungary. kissendre@stoma.szote	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Quintessence international (Berlin, Germany : 1985) Periodical, Abbrev. Quintessence Int. Pub Date Free Form Oct Volume 41 Issue 9 Start Page 779 Other Pages 785 Notes LR: 20131121; JID: 0342677; SY7Q814VUP (Calcium); ppublish Place of Publication Germany ISSN/ISBN 1936-7163; 0033-6572 Accession Number PMID: 20806103 Language eng SubFile Journal Article; D DOI 19524 [pii] Output Language Unknown(0) PMID 20806103 Abstract OBJECTIVE: The aim of this pilot study was to assess the possibility of differences in the calcium concentration of the saliva between smoker and nonsmoker patients with or without periodontitis. METHOD AND MATERIALS: A total of 44 women were enrolled in this study. Exclusion criteria were severe general health problems, the prescription of medication, and fewer than 16 remaining teeth. The study population comprised 24 smokers (4 periodontitis free, 16 with chronic and 4 with aggressive periodontitis; mean age 50.2 years +/- 6.9) and 20 nonsmokers (10 periodontitis free, 9 with chronic and 1 with aggressive periodontitis; mean age 54.7 years +/- 15.6). Clinical parameters (bone loss; plaque, gingival and calculus indices; and pocket depth) were recorded, and stimulated saliva samples were collected. The calcium concentration of each saliva sample was measured by atomic absorption spectrophotometry. Statistical analysis was performed with the MANOVA test. RESULTS: The mean salivary calcium level in the smokers (57.76 mug/mL +/- 18.8) was significantly (P < .05) higher than in the nonsmokers (44.6 mug/mL +/- 7.8). Periodontal examination revealed significantly greater bone loss, a deeper mean probing depth, and a higher amount of calculus (P < .05) among the smokers. However, there were no statistically significant differences between the smokers and the nonsmokers as concerns the plaque and bleeding indices. CONCLUSIONS: Within their limits, the present findings seem to indicate that patients with periodontitis who smoke exhibit higher salivary calcium levels than those in nonsmokers. However, the clinical significance of these findings remains to be determined in large-scale controlled studies. Descriptors Adult, Aged, Aggressive Periodontitis/classification/metabolism, Alveolar Bone Loss/classification, Calcium/analysis, Chronic Periodontitis/classification/metabolism, Dental Calculus/classification, Dental Plaque Index, Female, Gingival Hemorrhage/classification, Humans, Middle Aged, Oral Hygiene Index, Periodontal Index, Periodontal Pocket/classification, Pilot Projects, Saliva/chemistry, Smoking/metabolism, Spectrophotometry, Atomic Links Book Title Database Publisher Data Source Authors Kiss,E., Sewon,L., Gorzo,I., Nagy,K. Original/Translated Title URL Date of Electronic PMCID Editors
In vitro evaluation of antibiotic lock technique for the treatment of Candida albicans, C. glabrata, and C. tropicalis biofilms	2010	Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of Korean medical science Periodical, Abbrev. J.Korean Med.Sci. Pub Date Free Form Dec Volume 25 Issue 12 Start Page 1722 Other Pages 1726 Notes LR: 20150205; JID: 8703518; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Pyrimidines); 0 (Triazoles); 304NUG5GF4 (Itraconazole); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole); OID: NLM: PMC29952 Place of Publication Korea (South) ISSN/ISBN 1598-6357; 1011-8934 Accession Number PMID: 21165285 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.3346/jkms.2010.25.12.1722 [doi] Output Language Unknown(0) PMID 21165285 Abstract Candidaemia associated with intravascular catheter-associated infections is of great concern due to the resulting high morbidity and mortality. The antibiotic lock technique (ALT) was previously introduced to treat catheter-associated bacterial infections without removal of catheter. So far, the efficacy of ALT against Candida infections has not been rigorously evaluated. We investigated in vitro activity of ALT against Candida biofilms formed by C. albicans, C. glabrata, and C. tropicalis using five antifungal agents (caspofungin, amphotericin B, itraconazole, fluconazole, and voriconazole). The effectiveness of antifungal treatment was assayed by monitoring viable cell counts after exposure to 1 mg/mL solutions of each antibiotic. Fluconazole, itraconazole, and voriconazole eliminated detectable viability in the biofilms of all Candida species within 7, 10, and 14 days, respectively, while caspofungin and amphotericin B did not completely kill fungi in C. albicans and C. glabrata biofilms within 14 days. For C. tropicalis biofilm, caspofungin lock achieved eradication more rapidly than amphotericin B and three azoles. Our study suggests that azoles may be useful ALT agents in the treatment of catheter-related candidemia. Descriptors Amphotericin B/administration & dosage/pharmacology, Antifungal Agents/administration & dosage/pharmacology/therapeutic use, Biofilms/drug effects, Candida albicans/drug effects/physiology, Candida glabrata/drug effects/physiology, Candida tropicalis/drug effects/physiology, Candidiasis/drug therapy, Catheter-Related Infections/drug therapy, Catheterization, Central Venous, Drug Administration Routes, Echinocandins/administration & dosage/pharmacology, Fluconazole/administration & dosage/pharmacology, Humans, Itraconazole/administration & dosage/pharmacology, Microbial Sensitivity Tests, Pyrimidines/administration & dosage/pharmacology, Triazoles/administration & dosage/pharmacology, Voriconazole, Antibiotic Lock Technique, Biofilms, Candida Links Book Title Database Publisher Data Source Authors Ko,K. S., Lee,J. Y., Song,J. H., Peck,K. R. Original/Translated Title URL Date of Electronic 20101124 PMCID PMC2995224 Editors
Metabolic syndrome and angiographic coronary artery disease prevalence in association with the Framingham risk score	2010	First Cardiology Department, AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Metabolic syndrome and related disorders Periodical, Abbrev. Metab.Syndr.Relat.Disord. Pub Date Free Form Jun Volume 8 Issue 3 Start Page 201 Other Pages 208 Notes JID: 101150318; ppublish Place of Publication United States ISSN/ISBN 1557-8518; 1540-4196 Accession Number PMID: 20156070 Language eng SubFile Journal Article; IM DOI 10.1089/met.2009.0059 [doi] Output Language Unknown(0) PMID 20156070 Abstract BACKGROUND: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individual's 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. METHODS: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic syndrome was defined according to the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and the 10-year CAD risk was estimated by the FRS. RESULTS: Metabolic syndrome patients had a 2-fold higher CAD prevalence compared to those without metabolic syndrome [odds ratio (OR), 2.004; 95% confidence interval (CI), 1.029-3.905] but this finding was attenuated after adjustment for FRS (OR, 1.770; 95% CI, 0.872-3.594). Stratification of patients into three groups according to FRS revealed that metabolic syndrome predictive ability was confined in those being at <10% 10-year CAD risk. Including metabolic syndrome and its individual components into the same logistic regression model, only the glucose criterion was an independent predictor of angiographically significant CAD (OR, 4.137; 95% CI, 1.477-11.583). CONCLUSIONS: Metabolic syndrome is an independent determinant of angiographically significant CAD only among those individuals at low 10-year risk for future coronary events. Individual components of the syndrome, such as impaired fasting glucose, have a stronger association with CAD than the syndrome as a whole. Descriptors Aged, Chi-Square Distribution, Coronary Angiography, Coronary Artery Disease/epidemiology/etiology/radiography, Cross-Sectional Studies, Female, Greece/epidemiology, Humans, Logistic Models, Male, Metabolic Syndrome X/complications/diagnosis/epidemiology, Middle Aged, Odds Ratio, Prevalence, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors Links Book Title Database Publisher Data Source Authors Konstantinou,D. M., Chatzizisis,Y. S., Louridas,G. E., Giannoglou,G. D. Original/Translated Title URL Date of Electronic PMCID Editors

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