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In vitro susceptibility testing of Aspergillus spp. against voriconazole, itraconazole, posaconazole, amphotericin B and caspofungin 2010 Clinical Microbiology Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, China Academy of Medical Science, Beijing 100730, China.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Chinese medical journal
Periodical, Abbrev.
Chin.Med.J.(Engl)
Pub Date Free Form
Oct
Volume
123
Issue
19
Start Page
2706
Other Pages
2709
Notes
LR: 20141120; JID: 7513795; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Pyrimidines); 0 (Triazoles); 304NUG5GF4 (Itraconazole); 6TK1G07BHZ (posaconazole); 7XU7A7DROE (Amphotericin B); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole); ppublish
Place of Publication
China
ISSN/ISBN
0366-6999; 0366-6999
Accession Number
PMID: 21034656
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
21034656
Abstract
BACKGROUND: During recent years, the incidence of serious infections caused by opportunistic fungi has increased dramatically due to alterations of the immune status of patients with hematological diseases, malignant tumors, transplantations and so forth. Unfortunately, the wide use of triazole antifungal agents to treat these infections has lead to the emergence of Aspergillus spp. resistant to triazoles. The present study was to assess the in vitro activities of five antifungal agents (voriconazole, itraconazole, posaconazole, amphotericin B and caspofungin) against different kinds of Aspergillus spp. that are commonly encountered in the clinical setting. METHODS: The agar-based Etest MIC method was employed. One hundred and seven strains of Aspergillus spp. (5 species) were collected and prepared according to Etest Technique Manuel. Etest MICs were determined with RPMI agar containing 2% glucose and were read after incubation for 48 hours at 35 degrees C. MIC(50), MIC(90) and MIC range were acquired by Whonet 5.4 software. RESULTS: The MIC(90) of caspofungin against A. fumigatus, A. flavus and A. nidulans was 0.094 microg/ml whereas the MIC(90) against A. niger was 0.19 microg/ml. For these four species, the MIC(90) of caspofungin was the lowest among the five antifungal agents. For A. terrus, the MIC(90) of posaconazole was the lowest. For A. fumigatus and A. flavus, the MIC(90) in order of increasing was caspofungin, posaconazole, voriconazole, itraconazole, and amphotericin B. The MIC of amphotericin B against A. terrus was higher than 32 microg/ml in all 7 strains tested. CONCLUSIONS: The in vitro antifungal susceptibility test shows the new drug caspofungin, which is a kind of echinocandins, has good activity against the five species of Aspergillus spp. and all the triazoles tested have better in vitro activity than traditional amphotericin B.
Descriptors
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Aspergillus/drug effects, Echinocandins/pharmacology, Itraconazole/pharmacology, Microbial Sensitivity Tests, Pyrimidines/pharmacology, Triazoles/pharmacology, Voriconazole
Links
Book Title
Database
Publisher
Data Source
Authors
Shi,J. Y., Xu,Y. C., Shi,Y., Lu,H. X., Liu,Y., Zhao,W. S., Chen,D. M., Xi,L. Y., Zhou,X., Wang,H., Guo,L. N.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
6-{5-Amino-3-tert-butyl-4-[(E)-(3-methyl-1,2,4-thiadiazol-5-yl)diazen-yl]-1H-pyra zol-1-yl}-1,3,5-triazine-2,4(1H,3H)-dione-1-methyl-pyrrolidin-2-one-water (1/1/1) 2010 Department of Applied Physics, Graduate School of Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya-ku, Yokohama 240-8501, Japan.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
27-Mar
Volume
66
Issue
Pt 4
Start Page
o944
Other Pages
5
Notes
LR: 20130314; JID: 101089178; OID: NLM: PMC2983887; 2010/03/18 [received]; 2010/03/23 [accepted]; 2010/03/27 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 21580749
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536810010871 [doi]
Output Language
Unknown(0)
PMID
21580749
Abstract
In the title compound, C(13)H(16)N(10)O(2)S.C(5)H(9)NO.H(2)O, the entire 1-methylpyrrolidin-2-one (NMP) mol-ecule is disordered over two sites with occupancies of 0.488 (5) and 0.512 (5). The six-membered triazine ring and the two five-membered pyrazole and thiadia-zole rings, together with the diazene (-N=N-) linkage are almost coplanar (r.m.s. deviation for the non-H atoms = 0.0256 A) with methyl groups from the tert-butyl substituent on the pyrazole ring located above and below the plane. Three intra-molecular N-Hcdots, three dots, centeredN hydrogen bonds contribute to the planarity of the system. The O atom of the NMP mol-ecule is hydrogen bonded to an O-H group of water. In turn, the water mol-ecule is hydrogen bonded to the mono-azo skeleton through inter-molecular N-Hcdots, three dots, centeredO and O-Hcdots, three dots, centeredN hydrogen bonds. At both ends of the long mol-ecular axis of the main mol-ecule there are inter-molecular N-Hcdots, three dots, centeredN hydrogen bonds, arranged in a head-to-tail fashion, between the N-H group of the triazine ring of one mol-ecule and the N atom of the thia-diazole ring of a neighboring mol-ecule. These form a polymeric chain along [110] or [10]. The main mol-ecules are stacked alternately along the b axis, which effectively cancels their dipole moments. In addition, pairs of alternate molecules are dimerized via inter-molecular hydrogen bonds involving the solvent mol-ecules.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Shibata,H., Mizuguchi,J.
Original/Translated Title
URL
Date of Electronic
20100327
PMCID
PMC2983887
Editors
An intervention to stop smoking among patients suspected of TB--evaluation of an integrated approach 2010 Nuffield Centre for International Health and Development, Leeds Institute of Health Sciences, University of Leeds, Charles Thackrah Building, 101 Clarendon Road, Woodhouse, Leeds LS2 9LJ, UK. hssks@leeds.ac.uk
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC public health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
25-Mar
Volume
10
Issue
Start Page
160
Other Pages
2458-10-160
Notes
LR: 20141204; ISRCTN/ISRCTN08829879; GR: Medical Research Council/United Kingdom; JID: 100968562; 2010/03/09 [received]; 2010/03/25 [accepted]; 2010/03/25 [aheadofprint]; epublish
Place of Publication
England
ISSN/ISBN
1471-2458; 1471-2458
Accession Number
PMID: 20338041
Language
eng
SubFile
Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.1186/1471-2458-10-160 [doi]
Output Language
Unknown(0)
PMID
20338041
Abstract
BACKGROUND: In many low- and middle-income countries, where tobacco use is common, tuberculosis is also a major problem. Tobacco use increases the risk of developing tuberculosis, secondary mortality, poor treatment compliance and relapses. In countries with TB epidemic, even a modest relative risk leads to a significant attributable risk. Treating tobacco dependence, therefore, is likely to have benefits for controlling tuberculosis in addition to reducing the non-communicable disease burden associated with smoking. In poorly resourced health systems which face a dual burden of disease secondary to tuberculosis and tobacco, an integrated approach to tackle tobacco dependence in TB control could be economically desirable. During TB screening, health professionals come across large numbers of patients with respiratory symptoms, a significant proportion of which are likely to be tobacco users. These clinical encounters, considered to be "teachable moments", provide a window of opportunity to offer treatment for tobacco dependence. METHODS/DESIGN: We aim to develop and trial a complex intervention to reduce tobacco dependence among TB suspects based on the WHO 'five steps to quit' model. This model relies on assessing personal motivation to quit tobacco use and uses it as the basis for assessing suitability for the different therapeutic options for tobacco dependence.We will use the Medical Research Council framework approach for evaluating complex interventions to: (a) design an evidence-based treatment package (likely to consist of training materials for health professionals and education tools for patients); (b) pilot the package to determine the delivery modalities in TB programme (c) assess the incremental cost-effectiveness of the package compared to usual care using a cluster RCT design; (d) to determine barriers and drivers to the provision of treatment of tobacco dependence within TB programmes; and (e) support long term implementation. The main outcomes to assess the effectiveness would be point abstinence at 4 weeks and continuous abstinence up to 6 months. DISCUSSION: This work will be carried out in Pakistan and is expected to have relevance for other low and middle income countries with high tobacco use and TB incidence. This will enhance our knowledge of the cost-effectiveness of treating tobacco dependence in patients suspected of TB. TRIAL REGISTRATION: TRIAL REGISTRATION NUMBER: ISRCTN08829879.
Descriptors
Epidemics, Female, Health Promotion/methods, Humans, Male, Pakistan/epidemiology, Patient Compliance, Poverty, Randomized Controlled Trials as Topic/methods, Smoking/prevention & control, Smoking Cessation/methods, Tobacco Use Disorder/epidemiology/microbiology/prevention & control, Treatment Outcome, Tuberculosis/complications/epidemiology/prevention & control
Links
Book Title
Database
Publisher
Data Source
Authors
Siddiqi,K., Khan,A., Ahmad,M., Shafiq-ur-Rehman
Original/Translated Title
URL
Date of Electronic
20100325
PMCID
PMC2850346
Editors
Surveillance in Barrett's esophagus: an audit of practice 2010 Internal Medicine, Loma Linda Veterans Health Care System, Loma Linda, CA 92357, USA. adewaleajums@yahoo.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Digestive diseases and sciences
Periodical, Abbrev.
Dig.Dis.Sci.
Pub Date Free Form
Jun
Volume
55
Issue
6
Start Page
1615
Other Pages
1621
Notes
JID: 7902782; 2009/03/03 [received]; 2009/07/09 [accepted]; 2009/08/11 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1573-2568; 0163-2116
Accession Number
PMID: 19669878
Language
eng
SubFile
Journal Article; AIM; IM
DOI
10.1007/s10620-009-0917-y [doi]
Output Language
Unknown(0)
PMID
19669878
Abstract
GOALS: Determine the rates of follow-up, incident rate of cancer during surveillance, and changes in pathologic grade of patients with Barrett's esophagus during surveillance in a gastroenterology practice without a formal surveillance program. BACKGROUND: Barrett's esophagus is a pre-malignant condition. Surveillance endoscopy (SE) is recommended in order to detect and treat high-grade dysplasia and esophageal adenocarcinoma early and prevent deaths. SE has not been shown to have mortality benefit and several studies have questioned its cost-effectiveness. Most gastroenterology practices do not have a surveillance program for Barrett's esophagus. The few that exist are only in very specialized and funded programs. Little information exists on outcomes in patients with Barrett's esophagus outside of these well-structured surveillance programs. STUDY: A retrospective analysis of a cohort of patients with Barrett's esophagus diagnosed and surveyed between 1995 and 2005 at a Veterans Affairs medical center. Data were collected on age, body mass index, and race. Patients who missed their SE by 6 months or more and those that missed their SE by twice the recommended intervals or more were identified and analyzed for changes in pathologic grades. RESULTS: A total of 472 patients were diagnosed with Barrett's esophagus or had SE between 1995 and 2005. Three hundred and five patients only had one endoscopy and biopsy. They did not have follow-up surveillance endoscopies and biopsies. Two patients were excluded from the final analysis: one had an esophagectomy after an index diagnosis of high-grade dysplasia, and one had a diagnosis of esophageal adenocarcinoma 2 days after an initial impression of Barrett's esophagus. There were 165 patients with Barrett's metaplasia or dysplasia who had SE more than once and were included in the final analysis. Overall, 53.3% had no change in pathologic grade, 35.2% regressed to a lower pathologic grade, and 11.5% progressed to a higher grade. None (0/165, 0%) progressed to esophageal adenocarcinoma; 3.6% (6/165) progressed to high-grade dysplasia and 11.5% (19/165) regressed to normal mucosa. Forty-four patients missed their SE by 6 months or more. Of these, 50% regressed, 40.9% had no change, and 9.1% progressed. Four patients regressed to normal mucosa, one progressed to high-grade dysplasia and none progressed to esophageal adenocarcinoma. Twenty-three patients missed their SE by twice the recommended intervals or more. Of these, 60.9% regressed, 34.8% did not change, and 4.3% progressed. None progressed to esophageal adenocarcinoma or high-grade dysplasia but three regressed to normal mucosa. After adjusting for age and body mass index, patients with low-grade dysplasia are nearly seven times more likely to miss their endoscopy by twice the recommended intervals or more (OR 6.56, P-value 0.03). CONCLUSIONS: Most veteran patients with Barrett's esophagus do not undergo surveillance endoscopies. Veteran patients with Barrett's esophagus undergoing SE rarely progress to high-grade dysplasia or esophageal adenocarcinoma. Veteran patients with Barrett's esophagus who have longer SE up to twice the recommended intervals because they missed their scheduled SE did not have a worse outcome when compared to the general Barrett's esophagus surveillance group. Veteran patients with low-grade dysplasia are most likely to miss their SE by twice the recommended intervals or more, though the reason for this is unknown.
Descriptors
Aged, Barrett Esophagus/diagnosis/epidemiology/pathology, Biopsy, Disease Progression, Esophageal Neoplasms/diagnosis/epidemiology/pathology, Esophagoscopy/utilization, Female, Humans, Incidence, Logistic Models, Male, Mass Screening/methods/utilization, Medical Audit, Middle Aged, Patient Acceptance of Health Care, Precancerous Conditions/diagnosis/epidemiology/pathology, Predictive Value of Tests, Retrospective Studies, Time Factors, United States/epidemiology, United States Department of Veterans Affairs
Links
Book Title
Database
Publisher
Data Source
Authors
Ajumobi,A., Bahjri,K., Jackson,C., Griffin,R.
Original/Translated Title
URL
Date of Electronic
20090811
PMCID
Editors
Survey instruments used in clinical and epidemiological research on waterpipe tobacco smoking: a systematic review 2010
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC Public Health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
Volume
10
Issue
Start Page
415
Other Pages
415
Notes
ID: 20626899
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
BACKGROUND: The primary objective was to systematically review the medical literature for instruments validated for use in epidemiological and clinical research on waterpipe smoking. METHODS: We searched the following databases: MEDLINE, EMBASE, and ISI the Web of Science. We selected studies using a two-stage duplicate and independent screening process. We included papers reporting on the development and/or validation of survey instruments to measure waterpipe tobacco consumption or related concepts. Two reviewers used a standardized and pilot tested data abstraction form to collect data from each eligible study using a duplicate and independent screening process. We also determined the percentage of observational studies assessing the health effects of waterpipe tobacco smoking and the percentage of studies of prevalence of waterpipe tobacco smoking that have used validated survey instruments. RESULTS: We identified a total of five survey instruments. One instrument was designed to measure knowledge, attitudes, and waterpipe use among pregnant women and was shown to have internal consistency and content validity. Three instruments were designed to measure waterpipe tobacco consumption, two of which were reported to have face validity. The fifth instrument was designed to measure waterpipe dependence and was rigorously developed and validated. One of the studies of prevalence and none of the studies of health effects of waterpipe smoking used validated instruments. CONCLUSIONS: A number of instruments for measuring the use of and dependence on waterpipe smoking exist. Future research should study content validity and cross cultural adaptation of these instruments.
Descriptors
Data Collection/methods, Smoking/epidemiology, Epidemiologic Methods, Female, Humans, Pregnancy, Validation Studies as Topic
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912817/?tool=pubmed; http://dx.doi.org/10.1186/1471-2458-10-415
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Akl,Elie A., Aleem,Sohaib, Gunukula,Sameer K., Honeine,Roland, Abou Jaoude,Philippe, Irani,Jihad
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
The effects of waterpipe tobacco smoking on health outcomes: a systematic review 2010
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Int J Epidemiol
Periodical, Abbrev.
Int.J.Epidemiol.
Pub Date Free Form
Volume
39
Issue
3
Start Page
834
Other Pages
57
Notes
ID: 20207606
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
BACKGROUND: There is a need for a comprehensive and critical review of the literature to inform scientific debates about the public health effects of waterpipe smoking. The objective of this study was therefore to systematically review the medical literature for the effects of waterpipe tobacco smoking on health outcomes. METHODS: We conducted a systematic review using the Cochrane Collaboration methodology for conducting systematic reviews. We rated the quality of evidence for each outcome using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. RESULTS: Twenty-four studies were eligible for this review. Based on the available evidence, waterpipe tobacco smoking was significantly associated with lung cancer odds ratio (OR) = 2.12; 95% confidence interval (CI) 1.32-3.42], respiratory illness (OR = 2.3; 95% CI 1.1-5.1), low birth-weight (OR = 2.12; 95% CI 1.08-4.18) and periodontal disease (OR = 3-5). It was not significantly associated with bladder cancer (OR = 0.8; 95% CI 0.2-4.0), nasopharyngeal cancer (OR = 0.49; 95% CI 0.20-1.23), oesophageal cancer (OR = 1.85; 95% CI 0.95-3.58), oral dysplasia (OR = 8.33; 95% CI 0.78-9.47) or infertility (OR = 2.5; 95% CI 1.0-6.3) but the CIs did not exclude important associations. Smoking waterpipe in groups was not significantly associated with hepatitis C infection (OR = 0.98; 95% CI 0.80-1.21). The quality of evidence for the different outcomes varied from very low to low. CONCLUSION: Waterpipe tobacco smoking is possibly associated with a number of deleterious health outcomes. There is a need for high-quality studies to identify and quantify with confidence all the health effects of this form of smoking.
Descriptors
Neoplasms/epidemiology, Smoking/adverse effects, Cross-Sectional Studies, Culture, Esophageal Neoplasms/epidemiology, Female, Hepatitis C/epidemiology, Humans, Infertility, Male/epidemiology, Lung Neoplasms/epidemiology, Male, Nasopharyngeal Neoplasms/epidemiology, Odds Ratio, Pregnancy, Pregnancy Outcome, Risk Factors, Urinary Bladder Neoplasms/epidemiology
Links
http://dx.doi.org/10.1093/ije/dyq002
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Akl,Elie A., Gaddam,Swarna, Gunukula,Sameer K., Honeine,Roland, Jaoude,Philippe Abou, Irani,Jihad
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Prevalence of current smoking in Eastern province, Saudi Arabia 2010
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
East Mediterr Health J
Periodical, Abbrev.
East.Mediterr.Health J.
Pub Date Free Form
Volume
16
Issue
6
Start Page
671
Other Pages
6
Notes
ID: 20799597
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
All Saudi Arabian residents of the Eastern province of Saudi Arabia aged 30+ years completed a structured interview questionnaire about smoking. The prevalence of current smoking (smoked > 100 cigarettes or any tobacco products including waterpipe in lifetime and still smoking daily or occasionally for 1 month or more) among 196 268 respondents was 16.9% (28.7% among men and 4.5% among women). There was a significantly higher prevalence of smoking at younger ages in men and older ages in women. Multiple logistic regression analysis showed that factors independently associated with smoking were lower socioeconomic tatus, lower education, being divorced and occupations such as the military and self-employed.
Descriptors
Smoking/epidemiology, Adult, Age Distribution, Aged, Educational Status, Female, Focus Groups, Health Surveys, Humans, Income/statistics & numerical data, Logistic Models, Male, Marital Status, Mass Screening, Middle Aged, Occupations, Prevalence, Residence Characteristics/statistics & numerical data, Saudi Arabia/epidemiology, Sex Distribution
Links
http://pesquisa.bvsalud.org/ghl/resource/en/mdl-20799597
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Al-Turki,K., Al-Baghli,N., Al-Ghamdi,A., El-Zubaier,A., Al-Ghamdi,R., Alameer,M. M.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Harm perception, attitudes and predictors of waterpipe (shisha) smoking among secondary school adolescents in Al-Hassa, Saudi Arabia 2010
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Asian Pac J Cancer Prev
Periodical, Abbrev.
Pub Date Free Form
Volume
11
Issue
2
Start Page
293
Other Pages
301
Notes
ID: 20843104
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
OBJECTIVES: This study aimed to determine the prevalence and social determinants of waterpipe (WP) smoking among secondary school students in Al-Hassa, Saudi Arabia and to assess their health related knowledge and attitudes toward WP. SUBJECTS AND METHODS: A cross-sectional study was conducted with 1,652 Saudi secondary school students of both genders aged between 15-19 years selected by multistage sampling method. A self-administered anonymous Arabic version of Global Youth Tobacco Survey modified with items dedicated to WP smoking and to assess perception of health related hazards and attitudes towards WP was employed for data collection. RESULTS: Prevalence of current smokers 'all forms' was 30.3% among males (C.I= 27.5- 33.2%) and 8.5% in females (C.I= 6.6-10.9%). WP was used by 53.9% of the current tobacco users, significantly higher among older age students. Of the regular WP smokers, 20.7% smoked WP on daily basis, 23.8% weekly, 64.2% stated using flavored " Muassel " tobacco. Primary motives for WP smoking were outings with friends, company, boredom and wasting time. Of the total, 49.7% of students stated that WP smoking is less harmful than cigarettes, 60.5% believed that harmful substances were purified through water filtration, with non-addictive properties in 67.8%. Knowledge about health hazards of WP smoking was low, irrespective of student's smoking status. WP smoking is more socially acceptable than cigarettes (52.1%), represents a good opportunity for gathering of friends and family (33.8%), and smoking of WP can relieve stress and tensions (37.8%). Hierarchical regression analysis showed that socializing motives, cigarette smoking, smoking among close family and friends, male gender and increasing age were positive predictors for WP smoking. CONCLUSION: Social acceptability, poor knowledge of WP health related hazards and certain socio demographics are favoring the increasing current trend of WP use among adolescents in Al Hassa, Saudi Arabia.
Descriptors
Smoking/epidemiology, Smoking/psychology, Students/psychology, Students/statistics & numerical data, Tobacco Use Disorder/epidemiology, Adolescent, Adult, Attitude, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Prevalence, Risk Factors, Risk-Taking, Saudi Arabia/epidemiology, Schools, Social Environment, Questionnaires, Tobacco Use Disorder/prevention & control, Young Adult
Links
http://pesquisa.bvsalud.org/ghl/resource/en/mdl-20843104
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Amin,Tarek Tawfik, Amr,Mostafa Abdel Monem, Zaza,Burhan Omar, Suleman,Wassem
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Evaluation of periodontal status in subjects with hyperlipidemia 2010 College of Dentistry at King Saud University in Riyadh, Saudi Arabia. fawartani@hotmail.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The journal of contemporary dental practice
Periodical, Abbrev.
J.Contemp.Dent.Pract.
Pub Date Free Form
1-Mar
Volume
11
Issue
2
Start Page
33
Other Pages
40
Notes
LR: 20131121; JID: 101090552; 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol); epublish
Place of Publication
United States
ISSN/ISBN
1526-3711; 1526-3711
Accession Number
PMID: 20228985
Language
eng
SubFile
Comparative Study; Journal Article; D; IM
DOI
1526-3711-673 [pii]
Output Language
Unknown(0)
PMID
20228985
Abstract
AIM: The aim of this study was to evaluate the periodontal status in subjects with hyperlipidemia and to determine whether there is any association between hyperlipidemia and periodontal disease. METHODS AND MATERIALS: Sixty female patients were enrolled in the study; group one is hyperlipidemic patients (30 subjects) and group 2 is systemically fit patients within the same age group (control; 30 subjects). In both groups body mass index (BMI) and clinical parameters were measured; plaque index (PI), bleeding on probing (BOP), pocket depth (PPD) as well as clinical attachment level (CAL) and biochemical parameters, including plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, were evaluated. RESULTS: The mean values of BMI, PPD, CAL, PI (%), and BOP (%) for the hyperlipidemia group were significantly higher than those for the control group. Total cholesterol and LDL-C levels were significantly and positively associated with CAL. Plasma triglyceride level was significantly associated with PPD and CAL. CONCLUSIONS: The results of our study showed that female patients with hyperlipidemia had higher values of periodontal parameters compared to control individuals. However, in the future studies with larger sample sizes in mixed gender populations are needed to determine the association between hyperlipidemia and periodontal disease. CLINICAL SIGNIFICANCE: The results of our study showed that female patients with hyperlipidemia might manifest clinically higher values of periodontal parameters compared to nonlipdemic individuals. However, due to the small sample size of this study the exact association between hyperlipidemia and periodontal disease is still uncertain. Care has to be taken with a hyperlipidemia patients and advice can be given to them for periodic periodontal checkup.
Descriptors
Adult, Body Mass Index, Case-Control Studies, Cholesterol/blood, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Cross-Sectional Studies, Dental Plaque Index, Female, Gingival Hemorrhage/classification, Humans, Hyperlipidemias/blood/complications, Middle Aged, Periodontal Attachment Loss/classification, Periodontal Diseases/complications, Periodontal Index, Periodontal Pocket/classification, Social Class, Triglycerides/blood
Links
Book Title
Database
Publisher
Data Source
Authors
Awartani,F., Atassi,F.
Original/Translated Title
URL
Date of Electronic
20100301
PMCID
Editors
Extreme and acquiescence bias in a bi-ethnic population 2010 School of Public Health, Faculty of Social Welfare and Health Studies, University of Haifa, Israel. ornaepel@research.haifa.ac.il
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
European journal of public health
Periodical, Abbrev.
Eur.J.Public Health
Pub Date Free Form
Oct
Volume
20
Issue
5
Start Page
543
Other Pages
548
Notes
LR: 20151119; JID: 9204966; 2010/05/03 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1464-360X; 1101-1262
Accession Number
PMID: 20439322
Language
eng
SubFile
Comparative Study; Journal Article; IM
DOI
10.1093/eurpub/ckq052 [doi]
Output Language
Unknown(0)
PMID
20439322
Abstract
BACKGROUND: Extreme and acquiescence biases are the tendency to give a positive or extreme answer regardless of the 'true' answer. These biases may compromise comparisons of attitudes regarding health between population groups. The aim of the study was to measure the extent of extreme and acquiescence biases and identify factors associated with them in two ethnic groups: Jews and Arabs in Israel. METHODS: A random telephone survey was conducted during 2006, interviewing 2322 Jews and 809 Arabs. Three attitude questions were presented twice with opposite wording to measure extreme and acquiescence biases in these two groups. RESULTS: Extreme bias ranged from 2 to 14% among Jews and from 6 to 29% among Arabs, depending on the question. Acquiescence bias ranged from 2 to 10% among Jews and 5-19% among Arabs. The less educated respondents gave more extreme biased responses for all items. The older respondents gave more extreme answers for two out of the three questions tested. After adjusting for age and education the odds ratio (OR) of giving more extreme biased answers was higher among Arabs compared with Jews for all three questions [OR = 2.49, confidence interval (CI) = 1.87, 3.31; OR = 2.33, CI = 1.75, 3.10; and OR = 2.94, CI = 1.83-4.71, respectively, for each question]. CONCLUSIONS: Levels of response biases are higher in the Arab minority population compared with the majority Jewish population and depended on the subject, age and education.
Descriptors
Adult, Arabs/psychology/statistics & numerical data, Bias (Epidemiology), Confidence Intervals, Cross-Sectional Studies, Disclosure, Female, Health Knowledge, Attitudes, Practice, Humans, Interviews as Topic, Israel, Jews/psychology/statistics & numerical data, Male, Middle Aged, Odds Ratio, Oral Hygiene/psychology, Population Surveillance, Prejudice, Smoking/ethnology, Socioeconomic Factors, Surveys and Questionnaires
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Authors
Baron-Epel,O., Kaplan,G., Weinstein,R., Green,M. S.
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20100503
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