WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Barrett's oesophagus: Evidence from the current meta-analyses	2014	Piers Gatenby, Division of Surgery and Interventional Science, University College London, London NW32QG, United Kingdom.; Piers Gatenby, Division of Surgery and Interventional Science, University College London, London NW32QG, United Kingdom.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full World journal of gastrointestinal pathophysiology Periodical, Abbrev. World J.Gastrointest.Pathophysiol. Pub Date Free Form 15-Aug Volume 5 Issue 3 Start Page 178 Other Pages 187 Notes LR: 20140820; JID: 101547471; OID: NLM: PMC4133517; OTO: NOTNLM; 2013/12/31 [received]; 2014/04/05 [revised]; 2014/05/29 [accepted]; ppublish Place of Publication United States ISSN/ISBN 2150-5330; 2150-5330 Accession Number PMID: 25133020 Language eng SubFile Journal Article; Review DOI 10.4291/wjgp.v5.i3.178 [doi] Output Language Unknown(0) PMID 25133020 Abstract Guidelines have been published regarding the management of Barrett's oesophagus (columnar-lined oesophagus). These have examined the role of surveillance in an effort to detect dysplasia and early cancer. The guidelines have provided criteria for enrolment into surveillance and some risk stratification with regard to surveillance interval. The research basis for the decisions reached with regard to cancer risk is weak and this manuscript has examined the available data published from meta-analyses up to 25(th) April 2013 (much of which has been published since the guidelines and their most recent updates have been written). There were 9 meta-analyses comparing patients with Barrett's oesophagus to control populations. These have demonstrated that Barrett's oesophagus is more common in males than females, in subjects who have ever smoked, in subjects with obesity, in subjects with prolonged symptoms of gastro-oesophageal reflux disease, in subjects who do not have infection with Helicobacter pylori and in subjects with hiatus hernia. These findings should inform public health measures in reducing the risk of Barrett's oesophagus and subsequent surveillance burden and cancer risk. There were 8 meta-analyses comparing different groups of patients with Barrett's oesophagus with regard to cancer risk. These have demonstrated that there was no statistically significant benefit of antireflux surgery over medical therapy, that endoscopic ablative therapy was effective in reducing cancer risk that there was similar cancer risk in patients with Barrett's oesophagus independent of geographic origin, that the adenocarcinoma incidence in males is twice the rate in females, that the cancer risk in long segment disease showed a trend to be higher than in short segment disease, that there was a trend for higher cancer risk in low-grade dysplasia over non-dysplastic Barrett's oesophagus, that there is a lower risk in patients with Helicobacter pylori infection and that there is a significant protective effect of aspirin and statins. There were no meta-analyses examining the role of intestinal metaplasia. These results demonstrate that guidance regarding surveillance based on the presence of intestinal metaplasia, segment length and the presence of low-grade dysplasia has a weak basis, and further consideration should be given to gender and helicobacter status, ablation of the metaplastic segment as well as the chemoprotective role of aspirin and statins. Descriptors Links Book Title Database Publisher Data Source Authors Gatenby,P., Soon,Y. Original/Translated Title URL Date of Electronic PMCID PMC4133517 Editors
Identification of lactic acid bacteria in salted Chinese cabbage by SDS-PAGE and PCR-DGGE	2014	Department of Food Science and Biotechnology, and Institute of Life Sciences and Resources, Kyung Hee University, Yongin, 446-701, Korea.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the science of food and agriculture Periodical, Abbrev. J.Sci.Food Agric. Pub Date Free Form 30-Jan Volume 94 Issue 2 Start Page 296 Other Pages 300 Notes CI: (c) 2013; JID: 0376334; 0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S); OTO: NOTNLM; 2013/04/01 [received]; 2013/05/20 [revised]; 2013/06/08 [accepted]; 2013/07/17 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1097-0010; 0022-5142 Accession Number PMID: 23749756 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1002/jsfa.6257 [doi] Output Language Unknown(0) PMID 23749756 Abstract BACKGROUND: Lactic acid bacteria (LAB) in salted Chinese cabbage, the main ingredient of kimchi, were analyzed by culture-dependent sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), followed by sequencing of the 16S rRNA gene and by culture-independent polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE), followed by sequencing of the V3 region of the 16S rRNA gene. The results were compared to those of LAB that had previously been found in kimchi. RESULTS: The two identification methods produced distinct overall LAB profiles. The PCR-DGGE method detected a more diverse microflora, including non-LAB strains. The culture-dependent method uniquely detected Weissella sp. and was able to provide the quantitative distribution of LAB in samples. However, Leuconostoc mesenteroides, Lactobacillus curvatus and Leuconostoc carnosum, which had also been reported as the dominant LAB in kimchi in previous studies, were identified by both methods. CONCLUSION: The two identification methods gave different bacterial profiles, while both methods were sufficient to identify the most prevalent LAB in salted Chinese cabbage samples. The quantitative feature of the culture-dependent identification method would make it preferable for studying and monitoring LAB viability in kimchi at each fermentation stage. The availability of the culture-independent identification method to identify a broader bacterial profile, including non-LAB, would make it a more effective tool for controlling contamination of undesirable bacteria during kimchi fermentation. Descriptors Links Book Title Database Publisher Society of Chemical Industry Data Source Authors Hong,Y., Yang,H.S., Li,J., Han,S.K., Chang,H.C., Kim,H.Y. Original/Translated Title URL Date of Electronic 20130717 PMCID Editors
Particulate mass and polycyclic aromatic hydrocarbons exposure from secondhand smoke in the back seat of a vehicle	2014	Department of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Jan Volume 23 Issue 1 Start Page 14 Other Pages 20 Notes LR: 20151119; JID: 9209612; 0 (Particulate Matter); 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); 2012/11/21 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 23172398 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1136/tobaccocontrol-2012-050531 [doi] Output Language Unknown(0) PMID 23172398 Abstract CONTEXT: Exposure to secondhand smoke (SHS) has been reduced in the USA by banning smoking in public places. These restrictions have not had the same effect on children's exposure to SHS as adults suggesting that children are exposed to SHS in locations not covered by bans, such as private homes and cars. OBJECTIVES: Assess exposure to SHS in the backseat of a stationary vehicle where a child would sit, quantify exposures to fine particulates (PM2.5), polycyclic aromatic hydrocarbons (PAH), carbon monoxide (CO) and nicotine. Estimate the impact on a child's mean daily exposure to PM2.5. METHODS: SHS exposures in stationary vehicles with two different window configurations were monitored. A volunteer smoked three cigarettes in a one-hour period for twenty-two experiments. PM2.5, CO, nicotine and PAH where measured in the backseat of the vehicle. 16 PAH compounds were measured for in gas and particle phases as well as real-time particle phase concentrations. RESULTS: The mean PAH concentration, 1325.1 ng/m(3), was larger than concentrations measured in bars and restaurants were smoking is banned in many countries. We estimate that a child spending only ten minutes in the car with a smoker at the mean PM2.5 concentration measured in the first window configuration--1697 mg/m(3)--will cause a 30% increase to the daily mean PM2.5 personal average of a child. CONCLUSIONS: Estimates made using the measured data and previously reported PM2.5 daily mean concentrations for children in California showing that even short exposure periods are capable of creating large exposure to smoke. Descriptors Links Book Title Database Publisher Data Source Authors Northcross,A.L., Trinh,M., Kim,J., Jones,I.A., Meyers,M.J., Dempsey,D.D., Benowitz,N.L., Hammond,S.K. Original/Translated Title URL Date of Electronic 20121121 PMCID Editors
Youth curiosity about cigarettes, smokeless tobacco, and cigars: prevalence and associations with advertising	2014	Office of Science, Center for Tobacco Products, Food and Drug Administration, Rockville. Electronic address: david.portnoy@fda.hhs.gov.; Office of Extramural Research, NIH, Bethesda, Maryland.; Office of Science, Center for Tobacco Products, Food and Drug	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Preventive Medicine Periodical, Abbrev. Am.J.Prev.Med. Pub Date Free Form Aug Volume 47 Issue 2 Suppl 1 Start Page S76 Other Pages 86 Notes CI: Published by Elsevier Inc.; JID: 8704773; 2013/12/10 [received]; 2014/04/24 [revised]; 2014/04/29 [accepted]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-2607; 0749-3797 Accession Number PMID: 25044199 Language eng SubFile Journal Article; IM DOI 10.1016/j.amepre.2014.04.012 [doi] Output Language Unknown(0) PMID 25044199 Abstract BACKGROUND: Curiosity about cigarettes is a reliable predictor of susceptibility to smoking and established use among youth. Related research has been limited to cigarettes, and lacks national-level estimates. Factors associated with curiosity about tobacco products, such as advertising, have been postulated but rarely tested. PURPOSE: To describe the prevalence of curiosity about cigarettes, smokeless tobacco, and cigars among youth and explore the association between curiosity and self-reported tobacco advertising exposure. METHODS: Data from the 2012 National Youth Tobacco Survey, a nationally representative survey of 24,658 students, were used. In 2013, estimates weighted to the national youth school population were calculated for curiosity about cigarettes, smokeless tobacco, and cigars among never users of any tobacco product. Associations between tobacco advertising and curiosity were explored using multivariable regressions. RESULTS: Curiosity about cigarettes (28.8%); cigars (19.5%); and smokeless tobacco (9.7%) was found, and many youth were curious about more than one product. Exposure to point-of-sale advertising (e.g., OR=1.35, 95% CI=1.19, 1.54 for cigarette curiosity); tobacco company communications (e.g., OR=1.70, 95% CI=1.38, 2.09 for cigarette curiosity); and tobacco products, as well as viewing tobacco use in TV/movies (e.g., OR=1.37, 95% CI=1.20, 1.58 for cigarette curiosity) were associated with curiosity about each examined tobacco product. CONCLUSIONS: Despite decreasing use of tobacco products, youth remain curious about them. Curiosity is associated with various forms of tobacco advertising. These findings suggest the importance of measuring curiosity as an early warning signal for potential future tobacco use and evaluating continued efforts to limit exposure to tobacco marketing among youth. Descriptors Links Book Title Database Publisher Data Source Authors Portnoy,D.B., Wu,C.C., Tworek,C., Chen,J., Borek,N. Original/Translated Title URL Date of Electronic PMCID Editors
The changes in smoking related behaviours and second hand smoke after the smoking ban in Izmir	2014	Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. onurtura@yahoo.com.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tuberkuloz ve toraks Periodical, Abbrev. Tuberk.Toraks Pub Date Free Form Volume 62 Issue 1 Start Page 27 Other Pages 38 Notes LR: 20151119; JID: 0417364; 0 (Tobacco Smoke Pollution); ppublish Place of Publication Turkey ISSN/ISBN 0494-1373; 0494-1373 Accession Number PMID: 24814075 Language tur SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 24814075 Abstract INTRODUCTION: The aim of the study is to determine the views about law, change of second hand smoke (SHS) quantity, people's smoking related behaviours after the publishment of law which prohibits use of tobacco products in closed public areas. MATERIALS AND METHODS: Questionnaire including 47 questions was performed to 600 people, who were selected by Turkey Statistics Instutition to present population of Izmir. RESULTS: 53.7% of participants were female and 46.3% was male; the mean age was 41.5 +/- 15.6. 98% of all participants were aware of the law and 91.5% of them were supporting it. 42% of participants who succeeded in quitting had managed it after the ban. Restriction of areas, rise of prices and effects of SHS were the most popular reasons of reducing/quitting smoking after the law. Non-smokers were exposed to SHS at homes; 35.1%, at vehicles: 14.9%, at work places: 14.4%. The number of smoking cigarettes was reduced by 3.19 cigarettes/day. The rate of violation of the ban was 32.3%; only 21.3% of violators were warned. 96.4% of law supporters found law successful and sufficient. CONCLUSION: A big amount of participants thinks about quitting in Izmir; law is thought to have important effect on this decision. SHS has reduced mostly in public areas with ban, but law must be enlarged to prevent SHS at private areas such as houses, vehicles and workplaces. As a result; the ban encouraged smokers to quit and reduced SHS at public areas. We believe that paying more attention for law sanction and extending the borders of law and reviewing the ban, will make our country more smoke free from now. Descriptors Links Book Title Database Publisher Data Source Authors Turan,P.A., Ergor,G., Turan,O., Doganay,S., Kilinc,O. Original/Translated Title 4207 sayili yasanin yururluge girmesinden sonra sigara icme davranislari ve pasif maruziyet ile ilgili degisikliklerin saptanmasi URL Date of Electronic PMCID Editors
Household cleaning activities as noningestion exposure determinants of urinary trihalomethanes	2014	Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology , Irenes 95, Limassol, 3041, Cyprus.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Environmental science & technology Periodical, Abbrev. Environ.Sci.Technol. Pub Date Free Form Volume 48 Issue 1 Start Page 770 Other Pages 780 Notes JID: 0213155; 0 (Drinking Water); 0 (Trihalomethanes); EIN: Environ Sci Technol. 2014 Jun 17;48(12):7196; 2013/12/06 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1520-5851; 0013-936X Accession Number PMID: 24266582 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1021/es404220z [doi] Output Language Unknown(0) PMID 24266582 Abstract Previous epidemiological studies linking drinking water total trihalomethanes (THM) with pregnancy disorders or bladder cancer have not accounted for specific household cleaning activities that could enhance THM exposures. We examined the relation between household cleaning activities (washing dishes/clothes, mopping, toilet cleaning, and washing windows/surfaces) and urinary THM concentrations accounting for water sources, uses, and demographics. A cross-sectional study (n = 326) was conducted during the summer in Nicosia, Cyprus, linking household addresses to the geocoded public water pipe network, individual household tap water, and urinary THM measurements. Household tap water THM concentrations ranged between 3-129 mug L(-1), while the median (Q1, Q3) creatinine-adjusted urinary THM concentration in females (669 ng g(-1) (353, 1377)) was significantly (p /=36 y of age remained significant, even after adjusting for potential confounders. No significant (p > 0.05) association was observed between ingestion-based THM exposure equivalency units and urinary THM. Noningestion routes of THM exposures during performance of routine household cleaning activities were shown for the first time to exert a major influence on urinary THM levels. It is warranted that future pregnancy-birth cohorts include monitoring of noningestion household THM exposures in their study design. Descriptors Links Book Title Database Publisher Data Source Authors Charisiadis,P., Andra,S.S., Makris,K.C., Christodoulou,M., Christophi,C.A., Kargaki,S., Stephanou,E.G. Original/Translated Title URL Date of Electronic 20131206 PMCID Editors
Barrett esophagus in Asia: same disease with different pattern	2014	Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.; Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical endoscopy Periodical, Abbrev. Clin.Endosc. Pub Date Free Form Jan Volume 47 Issue 1 Start Page 15 Other Pages 22 Notes LR: 20140624; JID: 101576886; OID: NLM: PMC3928486; OTO: NOTNLM; 2013/12/01 [received]; 2013/12/16 [revised]; 2014/01/02 [accepted]; 2014/01/24 [epublish]; ppublish Place of Publication Korea (South) ISSN/ISBN 2234-2400; 2234-2400 Accession Number PMID: 24570879 Language eng SubFile Journal Article; Review DOI 10.5946/ce.2014.47.1.15 [doi] Output Language Unknown(0) PMID 24570879 Abstract Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia. Descriptors Links Book Title Database Publisher Data Source Authors Lee,H.S., Jeon,S.W. Original/Translated Title URL Date of Electronic 20140124 PMCID PMC3928486 Editors
Caspofungin at catheter lock concentrations eradicates mature biofilms of Candida lusitaniae and Candida guilliermondii	2014	Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.; Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Faculty of	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Aug Volume 58 Issue 8 Start Page 4953 Other Pages 4956 Notes LR: 20150201; CI: Copyright (c) 2014; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 0 (liposomal amphotericin B); 7XU7A7DROE (Amphotericin B); 9HLM53094I (anidulafungin); F0XDI6ZL63 (caspofungin); R10H71BSWG (micafungin); OID: Place of Publication United States ISSN/ISBN 1098-6596; 0066-4804 Accession Number PMID: 24890585 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1128/AAC.03117-14 [doi] Output Language Unknown(0) PMID 24890585 Abstract The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P Descriptors Links Book Title Database Publisher American Society for Microbiology. All Rights Reserved Data Source Authors Simitsopoulou,M., Kyrpitzi,D., Velegraki,A., Walsh,T.J., Roilides,E. Original/Translated Title URL Date of Electronic 20140602 PMCID PMC4136003 Editors
Association between Helicobacter pylori and Barrett's esophagus, erosive esophagitis, and gastroesophageal reflux symptoms	2014	Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan; Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: jhr@umi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Periodical, Abbrev. Clin.Gastroenterol.Hepatol. Pub Date Free Form Feb Volume 12 Issue 2 Start Page 239 Other Pages 245 Notes LR: 20150423; CI: Copyright (c) 2014; GR: K23 DK079291/DK/NIDDK NIH HHS/United States; GR: K23DK079291/DK/NIDDK NIH HHS/United States; GR: K24 DK080941/DK/NIDDK NIH HHS/United States; GR: K24DK080941/DK/NIDDK NIH HHS/United States; GR: P30 DK034933/DK/NID Place of Publication United States ISSN/ISBN 1542-7714; 1542-3565 Accession Number PMID: 23988686 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.cgh.2013.08.029 [doi] Output Language Unknown(0) PMID 23988686 Abstract BACKGROUND & AIMS: Infection with Helicobacter pylori, particularly the cytotoxin-associated gene A (cagA)+ strain, is believed to protect against Barrett's esophagus, but it is not clear if it protects against gastroesophageal reflux disease (GERD). We aimed to determine whether H pylori infection is associated with GERD symptoms, erosive esophagitis, and Barrett's esophagus within the same cohort. METHODS: We analyzed data from a case-control study of 533 men (ages, 50-79 y) who underwent colorectal cancer screening at 2 tertiary medical centers in Michigan between 2008 and 2011 and who also were recruited to undergo upper endoscopy. We assessed 80 additional men found to have Barrett's esophagus during clinically indicated upper-endoscopy examinations. Logistic regression was used to estimate the associations between serum antibodies against H pylori or cagA and GERD symptoms, esophagitis, and Barrett's esophagus, compared with randomly selected men undergoing colorectal cancer screens (n = 177). RESULTS: H pylori infection was associated inversely with Barrett's esophagus (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.29-0.97), particularly the cagA+ strain (OR, 0.36; 95% CI, 0.14-0.90). There was a trend toward an inverse association with erosive esophagitis (H pylori OR, 0.63; 95% CI, 0.37-1.08; and cagA+ OR, 0.47; 95% CI, 0.21-1.03). However, GERD symptoms were not associated with H pylori infection (OR, 0.948; 95% CI, 0.548-1.64; and cagA+ OR, 0.967; 95% CI, 0.461-2.03). CONCLUSIONS: Based on a case-control study, infection with H pylori, particularly the cagA+ strain, is associated inversely with Barrett's esophagus. We observed a trend toward an inverse association with esophagitis, but not with GERD symptoms. Descriptors Links Book Title Database Publisher AGA Institute. Published by Elsevier Inc Data Source Authors Rubenstein,J.H., Inadomi,J.M., Scheiman,J., Schoenfeld,P., Appelman,H., Zhang,M., Metko,V., Kao,J.Y. Original/Translated Title URL Date of Electronic 20130827 PMCID PMC3947027 Editors
Control of Ebola virus disease - firestone district, liberia, 2014	2014		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full MMWR.Morbidity and mortality weekly report Periodical, Abbrev. MMWR Morb.Mortal.Wkly.Rep. Pub Date Free Form 24-Oct Volume 63 Issue 42 Start Page 959 Other Pages 965 Notes JID: 7802429; ppublish Place of Publication United States ISSN/ISBN 1545-861X; 0149-2195 Accession Number PMID: 25340914 Language eng SubFile Journal Article; IM DOI mm6342a6 [pii] Output Language Unknown(0) PMID 25340914 Abstract On March 30, 2014, the Ministry of Health and Social Welfare (MOHSW) of Liberia alerted health officials at Firestone Liberia, Inc. (Firestone) of the first known case of Ebola virus disease (Ebola) inside the Firestone rubber tree plantation of Liberia. The patient, who was the wife of a Firestone employee, had cared for a family member with confirmed Ebola in Lofa County, the epicenter of the Ebola outbreak in Liberia during March-April 2014. To prevent a large outbreak among Firestone's 8,500 employees, their dependents, and the surrounding population, the company responded by 1) establishing an incident management system, 2) instituting procedures for the early recognition and isolation of Ebola patients, 3) enforcing adherence to standard Ebola infection control guidelines, and 4) providing differing levels of management for contacts depending on their exposure, including options for voluntary quarantine in the home or in dedicated facilities. In addition, Firestone created multidisciplinary teams to oversee the outbreak response, address case detection, manage cases in a dedicated unit, and reintegrate convalescent patients into the community. The company also created a robust risk communication, prevention, and social mobilization campaign to boost community awareness of Ebola and how to prevent transmission. During August 1-September 23, a period of intense Ebola transmission in the surrounding areas, 71 cases of Ebola were diagnosed among the approximately 80,000 Liberians for whom Firestone provides health care (cumulative incidence = 0.09%). Fifty-seven (80%) of the cases were laboratory confirmed; 39 (68%) of these cases were fatal. Aspects of Firestone's response appear to have minimized the spread of Ebola in the local population and might be successfully implemented elsewhere to limit the spread of Ebola and prevent transmission to health care workers (HCWs). Descriptors Links Book Title Database Publisher Data Source Authors Reaves,E.J., Mabande,L.G., Thoroughman,D.A., Arwady,M.A., Montgomery,J.M. Original/Translated Title URL Date of Electronic PMCID Editors

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