WTS database

Title	Pub Year Sort ascending	Author	SearchLink
Lifetime and current waterpipe use among adolescents in Tehran, Islamic Republic of Iran	2013		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit Periodical, Abbrev. East.Mediterr.Health J. Pub Date Free Form Dec Volume 19 Issue 12 Start Page 1003 Other Pages 1013 Notes LR: 20151119; JID: 9608387; ppublish Place of Publication Egypt ISSN/ISBN 1020-3397; 1020-3397 Accession Number PMID: 24684098 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 24684098 Abstract Waterpipe use among Iranian adolescents has become a matter for concern. A descriptive, cross-sectional community-based survey was performed in 2010 to determine the prevalence of waterpipe use and associated factors among Iranian adolescents in Tehran, Islamic Republic of Iran. After multi-stage, random cluster sampling 1201 adolescents aged 15-18 years old responded to a questionnaire based on the Youth Risk Behavior Surveillance. The prevalence of current waterpipe smoking (at least once in the previous 30 days) was 28.0%, significantly higher among males (34.8%) than females (21.4%). A total of 45.1% of adolescents reported lifetime use (ever use) of waterpipes and 34.2% had ever shared a waterpipe. In multivariate logistic regression analysis the significant correlates of current waterpipe use for both males and females were having smokers among friends and family members, while for males, older age and educational failure were also risk factors. Descriptors Links Book Title Database Publisher Data Source Authors Baheiraei,A., Hamzehgardeshi,Z., Mohammadi,M.R., Nedjat,S., Mohammadi,E. Original/Translated Title URL Date of Electronic PMCID Editors
Perception and knowledge on health risks by waterpipe tobacco-smoking tourists in a night spot of Bangkok, Thailand	2013		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the Medical Association of Thailand = Chotmaihet thangphaet Periodical, Abbrev. J.Med.Assoc.Thai. Pub Date Free Form Dec Volume 96 Suppl 5 Issue Start Page S42 Other Pages 8 Notes LR: 20151119; JID: 7507216; 059QF0KO0R (Water); ppublish Place of Publication Thailand ISSN/ISBN 0125-2208; 0125-2208 Accession Number PMID: 24851572 Language eng SubFile Journal Article; IM DOI Output Language Unknown(0) PMID 24851572 Abstract OBJECTIVE: To identify the perception level, and knowledge level of health risks due to waterpipe tobacco smoking, and knowledge about prohibition of waterpipe tobacco smoking, of foreign tourists in Thailand. MATERIAL AND METHOD: This is a descriptive cross-sectional study, carried out among foreign tourists in nightspots on Khao San Road area of Bangkok. Structured interview questionnaire was the data collection instrument for 176 convenience-sampling. RESULTS: More than half (52.3%) of the foreign tourists had a poor level of perception about waterpipe smoking. Majority of foreign tourists (75.5%) had low level of knowledge on the health risks. More than 50% didn't know about the illegal status of waterpipe smoking in Thailand. Chi-square analysis showed that the region where tourists reside was statistically associated with the perception level regarding waterpipe smoking. Age of waterpipe smoking initiation was associated with the region and gender Age of tourists was associated with the knowledge on prohibition of waterpipe smoking. CONCLUSION: Raising awareness among foreign tourists through media advocacy about the rules and regulations regarding waterpipe smoking is necessary to support tobacco control policy. Strict enforcement of the existing law on prohibiting waterpipe smoking should be implemented, Authorities should inform owners/managers of waterpipe, tobacco-smoking prohibition, and require them to put up prohibition signs in their establishments, in both Thai and English languages. Descriptors Links Book Title Database Publisher Data Source Authors Prutipinyo,C., Bhatt,N., Sirichotiratana,N. Original/Translated Title URL Date of Electronic PMCID Editors
Dynamical Structure of a Traditional Amazonian Social Network	2013	Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA ; Department of Anthropology, Emory University, 1557 Dickey Drive, Atlanta, GA 30322, USA.; Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA ; School of Informatics and Compu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Entropy (Basel, Switzerland) Periodical, Abbrev. Entropy (Basel) Pub Date Free Form 13-Nov Volume 15 Issue 11 Start Page 4932 Other Pages 4955 Notes GR: R01 AG024119/AG/NIA NIH HHS/United States; JID: 101243874; NIHMS601734; OTO: NOTNLM; ppublish Place of Publication ISSN/ISBN 1099-4300; 1099-4300 Accession Number PMID: 25053880 Language ENG SubFile JOURNAL ARTICLE DOI 10.3390/e15114932 [doi] Output Language Unknown(0) PMID 25053880 Abstract Reciprocity is a vital feature of social networks, but relatively little is known about its temporal structure or the mechanisms underlying its persistence in real world behavior. In pursuit of these two questions, we study the stationary and dynamical signals of reciprocity in a network of manioc beer (Spanish: chicha; Tsimane': shocdye') drinking events in a Tsimane' village in lowland Bolivia. At the stationary level, our analysis reveals that social exchange within the community is heterogeneously patterned according to kinship and spatial proximity. A positive relationship between the frequencies at which two families host each other, controlling for kinship and proximity, provides evidence for stationary reciprocity. Our analysis of the dynamical structure of this network presents a novel method for the study of conditional, or non-stationary, reciprocity effects. We find evidence that short-timescale reciprocity (within three days) is present among non- and distant-kin pairs; conversely, we find that levels of cooperation among close kin can be accounted for on the stationary hypothesis alone. Descriptors Links Book Title Database Publisher Data Source Authors Hooper,P.L., DeDeo,S., Caldwell Hooper,A.E., Gurven,M., Kaplan,H.S. Original/Translated Title URL Date of Electronic PMCID PMC4104206 Editors
Second-hand smoke and indoor air quality in public places in Gaza City	2013		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit Periodical, Abbrev. East.Mediterr.Health J. Pub Date Free Form May Volume 19 Issue 5 Start Page 447 Other Pages 451 Notes JID: 9608387; 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); ppublish Place of Publication Egypt ISSN/ISBN 1020-3397; 1020-3397 Accession Number PMID: 24617123 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 24617123 Abstract Second-hand smoke is a major cause of preventable disease and death in the Eastern Mediterranean Region. To assess how second-hand smoke impacts air quality, respirable suspended particles (PM2.5) which are emitted during cigarette and waterpipe smoking, were measured inside and outside of 18 smoking and 5 nonsmoking public venues in Gaza city. Median PM2.5 level inside the smoking venues was 117 microg/m3, which exceeds the WHO guidelines for daily PM2.5 exposure (25 microg/m3) by more than 4-fold. The median level inside the smoking venues (117 microg/m3) was significantly higher than outside the venues (43 microg/m3), and significantly higher than the median level inside non-smoking venues (40 microg/m3). By contrast particulate levels outside non-smoking venues (35 microg/m3) did not differ from the corresponding levels inside (40 microg/m3). To protect employees and the public from second-hand smoke exposure, policies prohibiting sinoking in public niaces are needed in Gaza city. Descriptors Links Book Title Database Publisher Data Source Authors Abuelaish,I., Seidenberg,A.B., Kennedy,R.D., Rees,V.W. Original/Translated Title URL Date of Electronic PMCID Editors
Indoor air quality in Virginia waterpipe cafes	2013	Department of Psychology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Sep Volume 22 Issue 5 Start Page 338 Other Pages 343 Notes LR: 20150225; GR: F31DA028102/DA/NIDA NIH HHS/United States; GR: R01CA120142/CA/NCI NIH HHS/United States; GR: R01DA024876/DA/NIDA NIH HHS/United States; GR: R01DA025659/DA/NIDA NIH HHS/United States; GR: R25 CA090314/CA/NCI NIH HHS/United States; GR: T32 Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 22447194 Language eng SubFile Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1136/tobaccocontrol-2011-050350 [doi] Output Language Unknown(0) PMID 22447194 Abstract INTRODUCTION: A revised indoor air quality law has been implemented in Virginia to protect the public from the harmful effects of secondhand smoke exposure. This legislation contains exemptions that include allowances for smoking in a room that is structurally separated and separately ventilated. The objective of the current study was to examine the impact of this law on air quality in waterpipe cafes, as well as to compare the air quality in these cafes to restaurants that allow cigarette smoking and those where no smoking is permitted. METHODS: Indoor air quality in 28 venues (17 waterpipe cafes, five cigarette smoking-permitted restaurants and six smoke-free restaurants (five with valid data)) in Virginia was assessed during 4 March to 27 May 2011. Real-time measurements of particulate matter (PM) with 2.5 mum aerodynamic diameter or smaller (PM2.5) were obtained and occupant behaviour/venue characteristics were assessed. RESULTS: The highest mean PM2.5 concentration was observed for waterpipe cafe smoking rooms (374 mug/m(3), n=17) followed by waterpipe cafe non-smoking rooms (123 mug/m(3), n=11), cigarette smoking-permitted restaurant smoking rooms (119 mug/m(3), n=5), cigarette smoking-permitted restaurant non-smoking rooms (26 mug/m(3), n=5) and smoke-free restaurants (9 mug/m(3), n=5). Smoking density was positively correlated with PM2.5 across smoking rooms and the smoke-free restaurants. In addition, PM2.5 was positively correlated between smoking and non-smoking rooms of venues. CONCLUSIONS: The PM2.5 concentrations observed among the waterpipe cafes sampled here indicated air quality in the waterpipe cafe smoking rooms was worse than restaurant rooms in which cigarette smoking was permitted, and state-required non-smoking rooms in waterpipe cafes may expose patrons and employees to PM2.5 concentrations above national and international air quality standards. Reducing the health risks of secondhand smoke may require smoke-free establishments in which tobacco smoking sources such as water pipes are, like cigarettes, prohibited. Descriptors Links Book Title Database Publisher Data Source Authors Cobb,C.O., Vansickel,A.R., Blank,M.D., Jentink,K., Travers,M.J., Eissenberg,T. Original/Translated Title URL Date of Electronic 20120324 PMCID PMC3889072 Editors
Smoking cessation interventions for smokers with current or past depression	2013	STIVORO, Dutch Expert Centre on Tobacco Control, The Hague, Netherlands.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 21-Aug Volume (8):CD006102. doi Issue 8 Start Page CD006102 Other Pages Notes LR: 20160602; JID: 100909747; 0 (Antidepressive Agents, Second-Generation); 01ZG3TPX31 (Bupropion); CIN: Evid Based Ment Health. 2014 May;17(2):e3. PMID: 24591546; epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 23963776 Language eng SubFile Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM DOI 10.1002/14651858.CD006102.pub2 [doi] Output Language Unknown(0) PMID 23963776 Abstract BACKGROUND: Individuals with current or past depression are often smokers who are more nicotine dependent, more likely to suffer from negative mood changes after nicotine withdrawal, and more likely to relapse to smoking after quitting than the general population, which contributes to their higher morbidity and mortality from smoking-related illnesses. It remains unclear what interventions can help them to quit smoking. OBJECTIVES: To evaluate the effectiveness of smoking cessation interventions, with and without specific mood management components, in smokers with current or past depression. SEARCH METHODS: In April 2013, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, other reviews, and asked experts for information on trials. SELECTION CRITERIA: Criteria for including studies in this review were that they had to be randomised controlled trials (RCTs) comparing smoking cessation interventions in adult smokers with current or past depression. Depression was defined as major depression or depressive symptoms. We included studies where subgroups of participants with depression were identified, either pre-stated or post hoc. The outcome was abstinence from smoking after six months or longer follow-up. We preferred prolonged or continuous abstinence and biochemically validated abstinence where available. DATA COLLECTION AND ANALYSIS: When possible, we estimated pooled risk ratios (RRs) with the Mantel-Haenszel method (fixed-effect model). We also performed subgroup analyses, by length of follow-up, depression measurement, depression group in study, antidepressant use, published or unpublished data, format of intervention, level of behavioural support, additional pharmacotherapy, type of antidepressant medication, and additional nicotine replacement therapy (NRT). MAIN RESULTS: Forty-nine RCTs were included of which 33 trials investigated smoking cessation interventions with specific mood management components for depression. In smokers with current depression, meta-analysis showed a significant positive effect for adding psychosocial mood management to a standard smoking cessation intervention when compared with standard smoking cessation intervention alone (11 trials, N = 1844, RR 1.47, 95% CI 1.13 to 1.92). In smokers with past depression we found a similar effect (13 trials, N = 1496, RR 1.41, 95% CI 1.13 to 1.77). Meta-analysis resulted in a positive effect, although not significant, for adding bupropion compared with placebo in smokers with current depression (5 trials, N = 410, RR 1.37, 95% CI 0.83 to 2.27). There were not enough trial data to evaluate the effectiveness of fluoxetine and paroxetine for smokers with current depression. Bupropion (4 trials, N = 404, RR 2.04, 95% CI 1.31 to 3.18) might significantly increase long-term cessation among smokers with past depression when compared with placebo, but the evidence for bupropion is relatively weak due to the small number of studies and the post hoc subgroups for all the studies. There were not enough trial data to evaluate the effectiveness of fluoxetine, nortriptyline, paroxetine, selegiline, and sertraline in smokers with past depression.Twenty-three of the 49 trials investigated smoking cessation interventions without specific components for depression. There was heterogeneity between the trials which compared psychosocial interventions with standard smoking cessation counselling for both smokers with current and past depression. Therefore, we did not estimate a pooled effect. One trial compared nicotine replacement therapy (NRT) versus placebo in smokers with current depression and found a positive, although not significant, effect (N = 196, RR 2.64, 95% CI 0.93 to 7.45). Meta-analysis also found a positive, although not significant, effect for NRT versus placebo in smokers with past depression (3 trials, N = 432, RR 1.17, 95% CI 0.85 to 1.60). Three trials compared other pharmacotherapy versus placebo and six tr Descriptors Links Book Title Database Publisher Data Source Authors van der Meer,R.M., Willemsen,M.C., Smit,F., Cuijpers,P. Original/Translated Title URL Date of Electronic 20130821 PMCID Editors
Tobacco cessation interventions for young people	2013	Heart of England Foundation Trust, 3, The Green, Shirley, UK, B90 4LA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 23-Aug Volume (8):CD003289. doi Issue 8 Start Page CD003289 Other Pages Notes LR: 20160602; JID: 100909747; epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 23975659 Language eng SubFile Journal Article; Meta-Analysis; Review; IM DOI 10.1002/14651858.CD003289.pub5 [doi] Output Language Unknown(0) PMID 23975659 Abstract BACKGROUND: Most tobacco control programmes for adolescents are based around prevention of uptake, but teenage smoking is still common. It is unclear if interventions that are effective for adults can also help adolescents to quit. This is the second update of a Cochrane review first published in 2006. OBJECTIVES: To evaluate the effectiveness of strategies that help young people to stop smoking tobacco. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group's Specialized Register in February 2013. This includes reports for trials identified in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and PsyclNFO. SELECTION CRITERIA: We included randomized controlled trials, cluster-randomized controlled trials and other controlled trials recruiting young people, aged less than 20, who were regular tobacco smokers. We included any interventions; these could include pharmacotherapy, psycho-social interventions and complex programmes targeting families, schools or communities. We excluded programmes primarily aimed at prevention of uptake. The primary outcome was smoking status after at least six months follow-up among those who smoked at baseline. DATA COLLECTION AND ANALYSIS: Both authors independently assessed the eligibility of candidate trials and extracted data. Included studies were evaluated for risk of bias using standard Cochrane methodology. Where meta-analysis was appropriate, we estimated pooled risk ratios using a Mantel-Haenszel fixed-effect method, based on the quit rates at longest follow-up. MAIN RESULTS: Twenty-eight trials involving approximately 6000 young people met our inclusion criteria (12 cluster-randomized controlled trials, 14 randomized controlled trials and 2 controlled trials). The majority of studies were judged to be at high or unclear risk of bias in at least one domain. Many studies combined components from various theoretical backgrounds to form complex interventions.The majority used some form of motivational enhancement combined with psychological support such as cognitive behavioural therapy (CBT) and some were tailored to stage of change using the transtheoretical model (TTM). Three trials based mainly on TTM interventions achieved moderate long-term success, with a pooled risk ratio (RR) of 1.56 at one year (95% confidence interval (CI) 1.21 to 2.01). The 12 trials that included some form of motivational enhancement gave an estimated RR of 1.60 (95% CI 1.28 to 2.01). None of the 13 individual trials of complex interventions that included cognitive behavioural therapy achieved statistically significant results, and results were not pooled due to clinical heterogeneity. There was a marginally significant effect of pooling six studies of the Not on Tobacco programme (RR of 1.31, 95% CI 1.01 to 1.71), although three of the trials used abstinence for as little as 24 hours at six months as the cessation outcome. A small trial testing nicotine replacement therapy did not detect a statistically significant effect. Two trials of bupropion, one testing two doses and one testing it as an adjunct to NRT, did not detect significant effects. Studies of pharmacotherapies reported some adverse events considered related to study treatment, though most were mild, whereas no adverse events were reported in studies of behavioural interventions. AUTHORS' CONCLUSIONS: Complex approaches show promise, with some persistence of abstinence (30 days point prevalence abstinence or continuous abstinence at six months), especially those incorporating elements sensitive to stage of change and using motivational enhancement and CBT. Given the episodic nature of adolescent smoking, more data is needed on sustained quitting. There were few trials with evidence about pharmacological interventions (nicotine replacement and bupropion), and none demonstrated effectiveness for adolescent smokers. There is not yet sufficient evidence to recommend widespread implementation of any one model. There c Descriptors Links Book Title Database Publisher Data Source Authors Stanton,A., Grimshaw,G. Original/Translated Title URL Date of Electronic 20130823 PMCID Editors
Nose-only water-pipe smoking effects on airway resistance, inflammation, and oxidative stress in mice	2013	Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates;	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of applied physiology (Bethesda, Md.: 1985) Periodical, Abbrev. J.Appl.Physiol.(1985) Pub Date Free Form 1-Nov Volume 115 Issue 9 Start Page 1316 Other Pages 1323 Notes JID: 8502536; 0 (Antioxidants); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione); OTO: NOTNLM; 2013/07/18 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1522-1601; 0161-7567 Accession Number PMID: 23869065 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1152/japplphysiol.00194.2013 [doi] Output Language Unknown(0) PMID 23869065 Abstract Water-pipe smoking (WPS) is a common practice in the Middle East and is now gaining popularity in Europe and the United States. However, there is a limited number of studies on the respiratory effects of WPS. More specifically, the underlying pulmonary pathophysiological mechanisms related to WPS exposure are not understood. Presently, we assessed the respiratory effects of nose-only exposure to mainstream WPS generated by commercially available honey flavored "moasel" tobacco. The duration of the session was 30 min/day and 5 days/wk for 1 mo. Control mice were exposed to air only. Here, we measured in BALB/c mice the airway resistance using forced-oscillation technique. Lung inflammation was assessed histopathologically and by biochemical analysis of bronchoalveolar lavage (BAL) fluid, and oxidative stress was evaluated biochemically by measuring lipid peroxidation, reduced glutathione and several antioxidant enzymes. Pulmonary inflammation assessment showed an increase in neutrophil and lymphocyte numbers. Likewise, airway resistance was significantly increased in the WPS group compared with controls. Tumor necrosis factor alpha and interleukin 6 concentrations were significantly increased in BAL fluid. Lipid peroxidation in lung tissue was significantly increased whereas the level and activity of antioxidants including reduced glutathione, glutathione S transferase, and superoxide dismutase were all significantly decreased following WPS exposure, indicating the occurrence of oxidative stress. Moreover, carboxyhemoglobin levels were significantly increased in the WPS group. We conclude that 1-mo nose-only exposure to WPS significantly increased airway resistance, inflammation, and oxidative stress. Our results provide a mechanistic explanation for the limited clinical studies that reported the detrimental respiratory effects of WPS. Descriptors Links Book Title Database Publisher Data Source Authors Nemmar,A., Raza,H., Yuvaraju,P., Beegam,S., John,A., Yasin,J., Hameed,R.S., Adeghate,E., Ali,B.H. Original/Translated Title URL Date of Electronic 20130718 PMCID Editors
Interventions for smoking cessation and reduction in individuals with schizophrenia	2013	Nottinghamshire Healthcare NHS Trust, Nottingham, UK. daniel.tsoi@nottshc.nhs.uk.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 28-Feb Volume (2):CD007253. doi Issue 2 Start Page CD007253 Other Pages Notes LR: 20160602; JID: 100909747; 0 (Antidepressive Agents, Second-Generation); 0 (Benzazepines); 0 (Nicotinic Agonists); 0 (Quinoxalines); 01ZG3TPX31 (Bupropion); 6M3C89ZY6R (Nicotine); W6HS99O8ZO (Varenicline); epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 23450574 Language eng SubFile Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM DOI 10.1002/14651858.CD007253.pub3 [doi] Output Language Unknown(0) PMID 23450574 Abstract BACKGROUND: Individuals with schizophrenia smoke more heavily than the general population and this contributes to their higher morbidity and mortality from smoking-related illnesses. It remains unclear what interventions can help them to quit or to reduce smoking. OBJECTIVES: To evaluate the benefits and harms of different treatments for nicotine dependence in schizophrenia. SEARCH METHODS: We searched electronic databases including MEDLINE, EMBASE and PsycINFO from inception to October 2012, and the Cochrane Tobacco Addiction Group Specialized Register in November 2012. SELECTION CRITERIA: We included randomised trials for smoking cessation or reduction, comparing any pharmacological or non-pharmacological intervention with placebo or with another therapeutic control in adult smokers with schizophrenia or schizoaffective disorder. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the eligibility and quality of trials, as well as extracted data. Outcome measures included smoking abstinence, reduction in the amount smoked and any change in mental state. We extracted abstinence and reduction data at the end of treatment and at least six months after the intervention. We used the most rigorous definition of abstinence or reduction and biochemically validated data where available. We noted any reported adverse events. Where appropriate, we pooled data using a random-effects model. MAIN RESULTS: We included 34 trials (16 trials of cessation; nine trials of reduction; one trial of relapse prevention; eight trials that reported smoking outcomes for interventions aimed at other purposes). Seven trials compared bupropion with placebo; meta-analysis showed that cessation rates after bupropion were significantly higher than placebo at the end of treatment (seven trials, N = 340; risk ratio [RR] 3.03; 95% confidence interval [CI] 1.69 to 5.42) and after six months (five trials, N = 214, RR 2.78; 95% CI 1.02 to 7.58). There were no significant differences in positive, negative and depressive symptoms between bupropion and placebo groups. There were no reports of major adverse events such as seizures with bupropion.Smoking cessation rates after varenicline were significantly higher than placebo, at the end of treatment (2 trials, N = 137; RR 4.74, 95% CI 1.34 to 16.71). Only one trial reported follow-up at six months and the CIs were too wide to provide evidence of a sustained effect (one trial, N = 128, RR 5.06, 95% CI 0.67 to 38.24). There were no significant differences in psychiatric symptoms between the varenicline and placebo groups. Nevertheless, there were reports of suicidal ideation and behaviours from two people on varenicline.Two studies reported that contingent reinforcement (CR) with money may increase smoking abstinence rates and reduce the level of smoking in patients with schizophrenia. However, it is uncertain whether these benefits can be maintained in the longer term. There was no evidence of benefit for the few trials of other pharmacological therapies (including nicotine replacement therapy (NRT)) and psychosocial interventions in helping smokers with schizophrenia to quit or reduce smoking. AUTHORS' CONCLUSIONS: Bupropion increases smoking abstinence rates in smokers with schizophrenia, without jeopardizing their mental state. Varenicline may also improve smoking cessation rates in schizophrenia, but its possible psychiatric adverse effects cannot be ruled out. CR may help this group of patients to quit and reduce smoking in the short term. We failed to find convincing evidence that other interventions have a beneficial effect on smoking in schizophrenia. Descriptors Links Book Title Database Publisher Data Source Authors Tsoi,D.T., Porwal,M., Webster,A.C. Original/Translated Title URL Date of Electronic 20130228 PMCID Editors
Relapse prevention interventions for smoking cessation	2013	Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 55 Philpot Street, London, UK, E1 2HJ.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 20-Aug Volume (8):CD003999. doi Issue 8 Start Page CD003999 Other Pages Notes LR: 20160602; GR: 14135/Cancer Research UK/United Kingdom; JID: 100909747; 0 (Benzazepines); 0 (Chewing Gum); 0 (Nicotinic Agonists); 0 (Quinoxalines); 6M3C89ZY6R (Nicotine); W6HS99O8ZO (Varenicline); epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 23963584 Language eng SubFile Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM DOI 10.1002/14651858.CD003999.pub4 [doi] Output Language Unknown(0) PMID 23963584 Abstract BACKGROUND: A number of treatments can help smokers make a successful quit attempt, but many initially successful quitters relapse over time. Several interventions have been proposed to help prevent relapse. OBJECTIVES: To assess whether specific interventions for relapse prevention reduce the proportion of recent quitters who return to smoking. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group trials register in May 2013 for studies mentioning relapse prevention or maintenance in title, abstracts or keywords. SELECTION CRITERIA: Randomized or quasi-randomized controlled trials of relapse prevention interventions with a minimum follow-up of six months. We included smokers who quit on their own, were undergoing enforced abstinence, or were participating in treatment programmes. We included trials that compared relapse prevention interventions with a no intervention control, or that compared a cessation programme with additional relapse prevention components with a cessation programme alone. DATA COLLECTION AND ANALYSIS: Studies were screened and data extracted by one review author, and checked by a second. Disagreements were resolved by discussion or by referral to a third review author. MAIN RESULTS: Sixty-three studies met inclusion criteria but were heterogeneous in terms of populations and interventions. We considered 41 studies that randomly assigned abstainers separately from studies that randomly assigned participants before their quit date.Upon looking at studies of behavioural interventions that randomly assigned abstainers, we detected no benefit of brief and 'skills-based' relapse prevention methods for women who had quit smoking because of pregnancy, or for smokers undergoing a period of enforced abstinence during hospitalisation or military training. We also failed to detect significant effects of behavioural interventions in trials in unselected groups of smokers who had quit on their own or through a formal programme. Amongst trials randomly assigning smokers before their quit date and evaluating the effects of additional relapse prevention components, we found no evidence of benefit of behavioural interventions or combined behavioural and pharmacotherapeutic interventions in any subgroup. Overall, providing training in skills thought to be needed for relapse avoidance did not reduce relapse, but most studies did not use experimental designs best suited to the task and had limited power to detect expected small differences between interventions. For pharmacological interventions, extended treatment with varenicline significantly reduced relapse in one trial (risk ratio (RR) 1.18, 95% confidence interval (CI) 1.03 to 1.36). Pooling of six studies of extended treatment with bupropion failed to detect a significant effect (RR 1.15, 95% CI 0.98 to 1.35). Two small trials of oral nicotine replacement treatment (NRT) failed to detect an effect, but treatment compliance was low, and in two other trials of oral NRT in which short-term abstainers were randomly assigned, a significant effect of intervention was noted. AUTHORS' CONCLUSIONS: At the moment, there is insufficient evidence to support the use of any specific behavioural intervention to help smokers who have successfully quit for a short time to avoid relapse. The verdict is strongest for interventions focused on identifying and resolving tempting situations, as most studies were concerned with these. Little research is available regarding other behavioural approaches.Extended treatment with varenicline may prevent relapse. Extended treatment with bupropion is unlikely to have a clinically important effect. Studies of extended treatment with nicotine replacement are needed. Descriptors Links Book Title Database Publisher Data Source Authors Hajek,P., Stead,L.F., West,R., Jarvis,M., Hartmann-Boyce,J., Lancaster,T. Original/Translated Title URL Date of Electronic 20130820 PMCID Editors

E-mail