WTS database

Title Sort ascending	Pub Year	Author	SearchLink
Detailed esophageal function and morphological analysis shows high prevalence of gastroesophageal reflux disease and Barrett's esophagus in patients with cervical inlet patch	2012	First Department of Medicine, Albert Szent-Gyorgyi Medical Centre, University of Szeged, Szeged State Health Centre, Budapest, Hungary. air@in1st.szote.u-szeged.hu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Periodical, Abbrev. Dis.Esophagus Pub Date Free Form Aug Volume 25 Issue 6 Start Page 498 Other Pages 504 Notes CI: (c) 2011 Copyright the Authors. Journal compilation (c) 2011; JID: 8809160; 2011/11/22 [aheadofprint]; ppublish Place of Publication Australia ISSN/ISBN 1442-2050; 1120-8694 Accession Number PMID: 22107367 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1111/j.1442-2050.2011.01281.x [doi] Output Language Unknown(0) PMID 22107367 Abstract Although the pathogenesis of cervical inlet patch (CIP) is not fully understood, most authors consider it as a congenital abnormality, whereas others surmise it to be related to gastroesophageal reflux disease (GERD). We aimed to evaluate esophageal function and the prevalence of GERD and Barrett's esophagus in patients with CIP. GERD is defined by the presence of erosive esophagitis or an abnormal pH monitoring. Seventy-one consecutive patients with endoscopic and histological evidence of CIP were prospectively evaluated. Esophageal symptom analysis, 24-hour simultaneous biliary reflux and double-channel pH-monitoring, and esophageal manometry were carried out in 65/71 (92%) patients and in 25 matched controls. Six patients were not suitable for testing and were, therefore, excluded. The histological evaluation of the heterotopic islands showed cardia and/or oxyntic mucosa in 64/65 (98%) patients and specialized intestinal metaplasia (SIM) in one patient (2%). The cardia and/or oxyntic mucosa was accompanied by focally appearing pancreatic acinar metaplasia and pancreatic ductal metaplasia in 7/64 (11%) and in 1/64 (2%), superficial mucous glands in 6/64 (9%), and SIM in 2/64 (3%) cases. In total, SIM was present in three patients (5%), and one of them had low-grade dysplasia. At the gastroesophageal junction, 28 (43%) patients had columnar metaplasia, including nine (14%) patients with SIM. Erosive esophagitis was present in 37 (57%) cases. Thirty-two patients (49%) had abnormal acid reflux in the distal and 25 (38%) in the proximal esophagus. Abnormal biliary reflux was present in 25 (38%) cases. On the basis of endoscopic and pH studies, GERD was established in 44/65 (68%) patients. Typical reflux symptoms were common (33/65, 51%). The combined 24-hour biliary and double-channel pH-monitoring detected significantly more significant acidic reflux at both measurement points and significantly longer bile exposure time in the distal esophagus in patients with CIP. Acid secretion in the CIP was detected in three (5%) cases. Esophageal manometry revealed decreased LES pressure and prolonged relaxation with decreased peristaltic wave amplitude, and an increased number of simultaneous contractions in the esophageal body. The detailed evaluation of the esophageal morphology and function in subjects with CIP showed a high prevalence of GERD and Barrett's esophagus. Further studies are needed to evaluate whether combined acidic and biliary reflux is able to promote similar histomorphological changes in the CIP, as it is shown distally in patients with Barrett's esophagus. Descriptors Links Book Title Database Publisher Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus Data Source Authors Rosztoczy,A., Izbeki,F., Nemeth,I.B., Dulic,S., Vadaszi,K., Roka,R., Gecse,K., Gyokeres,T., Lazar,G., Tiszlavicz,L., Wittmann,T. Original/Translated Title URL Date of Electronic 20111122 PMCID Editors
Detailed comparison of Candida albicans and Candida glabrata biofilms under different conditions and their susceptibility to caspofungin and anidulafungin	2011	Laboratory of Molecular Cell Biology, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of medical microbiology Periodical, Abbrev. J.Med.Microbiol. Pub Date Free Form Sep Volume 60 Issue Pt 9 Start Page 1261 Other Pages 1269 Notes LR: 20130527; JID: 0224131; 0 (Antifungal Agents); 0 (Culture Media); 0 (Echinocandins); 0 (Fungal Proteins); 0 (Polystyrenes); 9HLM53094I (anidulafungin); F0XDI6ZL63 (caspofungin); 2011/05/12 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1473-5644; 0022-2615 Accession Number PMID: 21566087 Language eng SubFile Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1099/jmm.0.032037-0 [doi] Output Language Unknown(0) PMID 21566087 Abstract Candida biofilm development can be influenced by diverse factors such as substrate, culture medium, carbohydrate source and pH. We have analysed biofilm formation of Candida albicans SC5314 and Candida glabrata ATCC 2001 wild-type strains in the presence of different media (RPMI 1640 versus YNB) and using different pH values (pH 5.6 or 7.0). We determined adhesion and biofilm formation on polystyrene, changes in the expression of adhesin genes during these processes and the susceptibility of mature biofilms to echinocandins. Biofilms formed on polystyrene by both Candida species proved to be influenced strongly by the composition of the medium rather than pH. C. albicans and C. glabrata formed thicker biofilms in RPMI 1640 medium, whereas in YNB medium, both species manifested adhesion rather than characteristic multilayer biofilm architecture. The stimulated biofilm formation in RPMI 1640 medium at pH 7.0 corroborated positively with increased expression of adhesin genes, essential to biofilm formation in vitro, including ALS3 and EAP1 in C. albicans and EPA6 in C. glabrata. The thicker biofilms grown in RPMI 1640 medium were more tolerant to caspofungin and anidulafungin than YNB-grown biofilms. We also observed that mature C. glabrata biofilms were less susceptible in RPMI 1640 medium to echinocandins than C. albicans biofilms. Environmental conditions, i.e. medium and pH, can significantly affect not only biofilm architecture, but also the expression profile of several genes involved during the different stages of biofilm development. In addition, growth conditions may also influence the antifungal-susceptibility profile of fungal populations within biofilm structures. Therefore, before designing any experimental biofilm set-up, it is important to consider the potential influence of external environmental factors on Candida biofilm development. Descriptors Links Book Title Database Publisher Data Source Authors Kucharikova,S., Tournu,H., Lagrou,K., Van Dijck,P., Bujdakova,H. Original/Translated Title URL Date of Electronic 20110512 PMCID Editors
Design, baseline results of Irbid longitudinal, school-based smoking study	2011		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Am J Health Behav Periodical, Abbrev. Am.J.Health Behav. Pub Date Free Form Volume 35 Issue 6 Start Page 746 Other Pages 55 Notes ID: 22251765 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract OBJECTIVE: To compare patterns of water pipe and cigarette smoking in an eastern Mediterranean country. METHODS: In 2008, 1781 out of 1877 seventh graders enrolled in 19 randomly selected schools in Irbid, Jordan, were surveyed. RESULTS: Experimentation with and current water pipe smoking were more prevalent than cigarette smoking (boys: 38.7% vs 26.8%; 20.2% vs 9.0%, girls: 21.2% vs 9.5%; and 7.5% vs 2.3%, P<0.05 for all). Parent- and peer-smoking correlated more strongly with water pipe than with cigarette smoking. CONCLUSION: Water-pipe smoking is more prevalent than cigarette smoking at this early age. Descriptors Smoking/epidemiology, Adolescent, Child, Female, Humans, Jordan/epidemiology, Longitudinal Studies, Male, Peer Group, Prevalence, Research Design, Schools, Sex Factors, Questionnaires Links http://pesquisa.bvsalud.org/ghl/resource/en/mdl-22251765 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Mzayek,Fawaz, Khader,Yousef, Eissenberg,Thomas, Ward,Kenneth D., Maziak,Wasim Original/Translated Title URL Date of Electronic PMCID Editors
Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data	2011	Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS, USA. lcox@kumc.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Trials Periodical, Abbrev. Trials Pub Date Free Form 25-Jan Volume 12 Issue Start Page 22 Other Pages 12/22/6215 Notes LR: 20151119; ClinicalTrials.gov/NCT00666978; GR: 1P60MD003422/MD/NIMHD NIH HHS/United States; GR: R01 CA091912/CA/NCI NIH HHS/United States; GR: R01 CA091912-09/CA/NCI NIH HHS/United States; GR: R01 CA091912-09S1/CA/NCI NIH HHS/United States; GR: R01CA09 Place of Publication England ISSN/ISBN 1745-6215; 1745-6215 Accession Number PMID: 21266057 Language eng SubFile Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1186/1745-6215-12-22 [doi] Output Language Unknown(0) PMID 21266057 Abstract BACKGROUND: African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use = 10 cigarettes per day). African Americans have been under-represented in smoking cessation research, and few studies have evaluated treatment for light smokers. This paper describes the study design, measures, and baseline characteristics from Kick It at Swope III (KIS-III), the first treatment study of bupropion for African American light smokers. METHODS: Five hundred forty African American light smokers were randomly assigned to receive bupropion (150 mg bid) (n = 270) or placebo (n = 270) for 7 weeks. All participants received written materials and health education counseling. Participants responded to survey items and provided blood samples for evaluation of phenotype and genotype of CYP2A6 and CYP2B6 enzymes involved in nicotine and bupropion metabolism. Primary outcome was cotinine-verified 7-day point prevalence smoking abstinence at Week 26 follow-up. RESULTS: Of 2,628 individuals screened, 540 were eligible, consented, and randomized to treatment. Participants had a mean age of 46.5 years and 66.1% were women. Participants smoked an average of 8.0 cigarettes per day, had a mean exhaled carbon monoxide of 16.4 ppm (range 1-55) and a mean serum cotinine of 275.8 ng/ml. The mean Fagerstrom Test for Nicotine Dependence was 3.2, and 72.2% of participants smoked within 30 minutes of waking. The average number of quit attempts in the past year was 3.7 and 24.2% reported using pharmacotherapy in their most recent quit attempt. Motivation and confidence to quit were high. CONCLUSION: KIS-III is the first study designed to examine both nicotine and bupropion metabolism, evaluating CYP2A6 and CYP2B6 phenotype and genotype in conjunction with psychosocial factors, in the context of treatment of African American light smokers. Of 1629 smokers screened for study participation, only 18 (1.1%) were ineligible to participate in the study because they refused blood draws, demonstrating the feasibility of recruiting and enrolling African American light smokers into a clinical treatment trial involving biological data collection and genetic analyses. Future evaluation of individual factors associated with treatment outcome will contribute to advancing tailored tobacco use treatment with the goal of enhancing treatment and reducing health disparities for African American light smokers. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00666978. Descriptors Links Book Title Database Publisher Data Source Authors Cox,L.S., Faseru,B., Mayo,M.S., Krebill,R., Snow,T.S., Bronars,C.A., Nollen,N.L., Choi,W.S., Okuyemi,K.S., Salzman,G.A., Benowitz,N.L., Tyndale,R.F., Ahluwalia,J.S. Original/Translated Title URL Date of Electronic 20110125 PMCID PMC3038942 Editors
Design and Validation of a Research-Grade Waterpipe Equipped With Puff Topography Analyzer	2016		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine Tob Res Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Volume 18 Issue 5 Start Page 785 Other Pages 93 Notes ID: 26377514 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract INTRODUCTION: Worldwide, commercially available waterpipes vary widely in design and durability, including differences in fabrication materials, degree of leak-tight fit, and flow path diameter. Little is known about how the components of the waterpipe may influence puffing behavior and user's exposure to toxins. To systematically evaluate exposure, it is necessary to use a standardized research-grade waterpipe (RWP) when conducting clinical and laboratory-based trials. METHODS: We developed a RWP that is configured with an in-line topography system which allows real-time measurement and recording of the smoke volume drawn through the RWP. The RWP was calibrated across the flow rate range expected for waterpipe tobacco smoking and the calibration was verified for known puff volumes using a smoking machine. Operation of the RWP was qualified in a cohort of experienced waterpipe smokers, each smoker using the RWP ad libitum in a laboratory setting while smoker topography and subjective effects data were collected. RESULTS: RWP machine smoking was highly reproducible and yielded puff volumes that agreed well with true values. User acceptance was comparable, and puffing behavior was similar in pattern, with more frequent puffing in the beginning of the session, but significantly different in intensity from that used to estimate the majority of toxicant exposure reported in the literature. CONCLUSIONS: The RWP operates with known precision and accuracy and is well accepted by experienced smokers. This tool can be used to determine the extent to which puffing behaviors are affected by the waterpipe design, components, and/or accessories, tobacco nicotine content, sweet flavorings and/or additives known to increase addictiveness. IMPLICATIONS: This study describes a standardized RWP, equipped with a puffing topography analyzer, which can operate with known precision and accuracy, and is well-accepted by experienced smokers in terms of satisfaction and reward. The RWP is an important tool for determining if puffing behaviors, and thus estimated toxin exposures, are affected by the waterpipe design, components, and/or accessories, tobacco nicotine content, sweet flavorings, and/or additives that are known to increase addictiveness. Descriptors Links http://dx.doi.org/10.1093/ntr/ntv180 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Brinkman,Marielle C., Kim,Hyoshin, Gordon,Sydney M., Kroeger,Robyn R., Reyes,Iza L., Deojay,Dawn M., Chitwood,Caleb, Lane,Timothy E., Clark,Pamela I. Original/Translated Title URL Date of Electronic PMCID Editors
Design and Synthesis of 3d-4f Metal-Based Zeolite-type Materials with a 3D Nanotubular Structure Encapsulated "Water" Pipe	2004	Cheng, P., Department of Chemistry, Nankai University, Tianjin 300071, China	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the American Chemical Society Periodical, Abbrev. J.Am.Chem.Soc. Pub Date Free Form 2004/03 Volume 126 Issue 10 Start Page 3012 Other Pages 3013 Notes Place of Publication ISSN/ISBN 0002-7863 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Descriptors lanthanide, manganese, nanotube, water, zeolite, article, complex formation, crystal structure, encapsulation, material state, phase transition, porosity, process design, structure analysis, synthesis, three dimensional imaging Links Book Title Database Embase Publisher Data Source Embase Authors Zhao,B., Cheng,P., Chen,X., Cheng,C., Shi,W., Liao,D., Yan,S., Jiang,Z. Original/Translated Title URL Date of Electronic PMCID Editors
Design and methods of the Population Assessment of Tobacco and Health (PATH) Study	2016	Roswell Park Cancer Institute, Buffalo, New York, USA.; Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.; National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Service	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form 8-Aug Volume Issue Start Page Other Pages Notes LR: 20160810; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/; JID: 9209612; OTO: NOTNLM; 2016/01/12 [rece Place of Publication ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 27507901 Language ENG SubFile JOURNAL ARTICLE DOI tobaccocontrol-2016-052934 [pii] Output Language Unknown(0) PMID 27507901 Abstract BACKGROUND: This paper describes the methods and conceptual framework for Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study data collection. The National Institutes of Health, through the National Institute on Drug Abuse, is partnering with the Food and Drug Administration's (FDA) Center for Tobacco Products to conduct the PATH Study under a contract with Westat. METHODS: The PATH Study is a nationally representative, longitudinal cohort study of 45 971 adults and youth in the USA, aged 12 years and older. Wave 1 was conducted from 12 September 2013 to 15 December 2014 using Audio Computer-Assisted Self-Interviewing to collect information on tobacco-use patterns, risk perceptions and attitudes towards current and newly emerging tobacco products, tobacco initiation, cessation, relapse behaviours and health outcomes. The PATH Study's design allows for the longitudinal assessment of patterns of use of a spectrum of tobacco products, including initiation, cessation, relapse and transitions between products, as well as factors associated with use patterns. Additionally, the PATH Study collects biospecimens from consenting adults aged 18 years and older and measures biomarkers of exposure and potential harm related to tobacco use. CONCLUSIONS: The cumulative, population-based data generated over time by the PATH Study will contribute to the evidence base to inform FDA's regulatory mission under the Family Smoking Prevention and Tobacco Control Act and efforts to reduce the Nation's burden of tobacco-related death and disease. Descriptors Links Book Title Database Publisher Data Source Authors Hyland,A., Ambrose,B.K., Conway,K.P., Borek,N., Lambert,E., Carusi,C., Taylor,K., Crosse,S., Fong,G.T., Cummings,K.M., Abrams,D., Pierce,J.P., Sargent,J., Messer,K., Bansal-Travers,M., Niaura,R., Vallone,D., Hammond,D., Hilmi,N., Kwan,J., Piesse,A., Kalton,G., Lohr,S., Pharris-Ciurej,N., Castleman,V., Green,V.R., Tessman,G., Kaufman,A., Lawrence,C., van Bemmel,D.M., Kimmel,H.L., Blount,B., Yang,L., O'Brien,B., Tworek,C., Alberding,D., Hull,L.C., Cheng,Y.C., Maklan,D., Backinger,C.L., Compton,W.M. Original/Translated Title URL Date of Electronic 20160808 PMCID Editors
Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease	2015	Warren Alpert School of Medicine, Brown University, Providence, RI. Electronic address: adam_levine@brown.edu.; International Medical Corps, Los Angeles, CA.; International Medical Corps, Los Angeles, CA.; International Medical Corps, Los Angeles, CA.; Wa	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of Emergency Medicine Periodical, Abbrev. Ann.Emerg.Med. Pub Date Free Form Sep Volume 66 Issue 3 Start Page 285 Other Pages 2930 Notes CI: Copyright (c) 2015; JID: 8002646; CIN: Ann Emerg Med. 2015 Sep;66(3):294-6. PMID: 26215669; 2015/02/03 [received]; 2015/03/01 [revised]; 2015/03/12 [accepted]; 2015/04/03 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1097-6760; 0196-0644 Accession Number PMID: 25845607 Language eng SubFile Journal Article; AIM; IM DOI 10.1016/j.annemergmed.2015.03.011 [doi] Output Language Unknown(0) PMID 25845607 Abstract STUDY OBJECTIVE: The current outbreak of Ebola virus disease in West Africa is the largest on record and has overwhelmed the capacity of local health systems and the international community to provide sufficient isolation and treatment of all suspected cases. The goal of this study is to develop a clinical prediction model that can help clinicians risk-stratify patients with suspected Ebola virus disease in the context of such an epidemic. METHODS: A retrospective analysis was performed of patient data collected during routine clinical care at the Bong County Ebola Treatment Unit in Liberia during its first 16 weeks of operation. The predictive power of 14 clinical and epidemiologic variables was measured against the primary outcome of laboratory-confirmed Ebola virus disease, using logistic regression to develop a final prediction model. Bootstrap sampling was used to assess the internal validity of the model and estimate its performance in a simulated validation cohort. RESULTS: Ebola virus disease testing results were available for 382 (97%) of 395 patients admitted to the Ebola treatment unit during the study period. A total of 160 patients (42%) tested positive for Ebola virus disease. Logistic regression analysis identified 6 variables independently predictive of laboratory-confirmed Ebola virus disease, including sick contact, diarrhea, loss of appetite, muscle pains, difficulty swallowing, and absence of abdominal pain. The Ebola Prediction Score, constructed with these 6 variables, had an area under the receiver operator characteristic curve of 0.75 (95% confidence interval 0.70 to 0.80) for the prediction of laboratory-confirmed Ebola virus disease. Patients with higher Ebola Prediction Scores had higher likelihoods of laboratory-confirmed Ebola virus disease. CONCLUSION: The Ebola Prediction Score can be used by clinicians as an adjunct to current Ebola virus disease case definitions to risk-stratify patients with suspected Ebola virus disease. Clinicians can use this new tool for the purpose of cohorting patients within the suspected-disease ward of an Ebola treatment unit or community-based isolation center to prevent nosocomial infection or as a triage tool when patient numbers overwhelm available capacity. Given the inherent limitations of clinical prediction models, however, a low-cost, point-of-care test that can rapidly and definitively exclude Ebola virus disease in patients should be a research priority. Descriptors Links Book Title Database Publisher American College of Emergency Physicians. Published by Elsevier Inc Data Source Authors Levine,A.C., Shetty,P.P., Burbach,R., Cheemalapati,S., Glavis-Bloom,J., Wiskel,T., Kesselly,J.K. Original/Translated Title URL Date of Electronic 20150403 PMCID Editors
Depressive symptoms and cigarette smoking among teens	2000	Division of Adolescent Medicine, Children's Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. goode?@chmcc.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pediatrics Periodical, Abbrev. Pediatrics Pub Date Free Form Oct Volume 106 Issue 4 Start Page 748 Other Pages 755 Notes LR: 20071114; GR: P01-HD31921/HD/NICHD NIH HHS/United States; JID: 0376422; ppublish Place of Publication UNITED STATES ISSN/ISBN 1098-4275; 0031-4005 Accession Number PMID: 11015518 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; IM DOI Output Language Unknown(0) PMID 11015518 Abstract CONTEXT: Although several risk factors for tobacco use have been implicated in the development of depression, smoking progression has typically been viewed as a consequence of depression. The results of limited longitudinal studies are controversial. OBJECTIVE: To assess the nature and direction of the relationship between cigarette smoking and depression among teens. DESIGN: Prospective analysis of baseline and 1-year follow-up data from the National Longitudinal Study of Adolescent Health. SETTING: In-home teen and parent interviews. PARTICIPANTS: Two samples were identified. For the first sample, 8704 adolescents who were not depressed at baseline based on CES-D scores were identified for analyses of the effects of cigarette smoking on development of high depressive symptomatology. Baseline smoking status, which could vary in this group, was the predictor of interest in these analyses. For the second sample, 6947 teens who had not smoked cigarettes in the 30 days before the baseline survey (noncurrent smokers) were identified for analyses on the effect of high depressive symptoms on subsequent moderate to heavy cigarette use at 1 year of follow-up. Baseline high depressive symptomatology based on CES-D score was the predictor of interest in this sample. MAIN OUTCOME MEASURES: Among the nondepressed, developing high depressive symptoms at 1 year of follow-up. Among noncurrent smokers, smoking at least 1 pack per week at 1 year of follow-up. RESULTS: For the nondepressed, multivariate modeling revealed that current cigarette smoking was the strongest predictor of developing high depressive symptoms in all models (final model odds ratio [OR]: 3.90; 95% confidence interval [CI]: 1.85,8.20). For noncurrent smokers, although in bivariate analyses, baseline high depressive symptoms increased the risk of heavy smoking nearly threefold, multivariate modeling revealed that baseline high depressive symptoms were not predictive of heavy smoking when controlling for other determinants of smoking in teens. Previous experimentation with smoking was the strongest predictor of becoming a heavy smoker (OR: 3.04; 95% CI: 1.93,4.88). CONCLUSIONS: In contrast to common dictum, depression does not seem to be an antecedent to heavy cigarette use among teens. However, current cigarette use is a powerful determinant of developing high depressive symptoms. Descriptors Adolescent, Adolescent Behavior, Depression/complications, Depressive Disorder/complications, Female, Health Surveys, Humans, Logistic Models, Longitudinal Studies, Male, Multivariate Analysis, Risk Factors, Smoking/epidemiology/ethnology/psychology, Social Class, United States/epidemiology Links Book Title Database Publisher Data Source Authors Goodman,E., Capitman,J. Original/Translated Title URL Date of Electronic PMCID Editors
Depressive symptoms and bone mineral density in menopause and postmenopausal women: A still increasing and neglected problem	2016	Department of Biostatistics and Medical Informatics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of family medicine and primary care Periodical, Abbrev. J.Family Med.Prim.Care. Pub Date Free Form Jan-Mar Volume 5 Issue 1 Start Page 143 Other Pages 149 Notes LR: 20160729; JID: 101610082; OID: NLM: PMC4943122; OTO: NOTNLM; ppublish Place of Publication India ISSN/ISBN 2249-4863; 2249-4863 Accession Number PMID: 27453860 Language eng SubFile Journal Article DOI 10.4103/2249-4863.184640 [doi] Output Language Unknown(0) PMID 27453860 Abstract BACKGROUND: The association between depression and loss of bone mineral density (BMD) has been reported as controversial. OBJECTIVE: The objective of the current study was to investigate whether an association exists between depression and low BMD during the menopausal and postmenopausal period. MATERIALS AND METHODS: A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian women at the Primary Health Care Centers in Qatar. A multi-stage sampling design was used, and a representative sample of 1650 women aged 45-65 years were included during July 2012 and November 2013. This prospective study explored the association between bone density and major depressive disorder in women. Bone mineral densitometry measurements (BMD) (g/m(2)) were assessed at the BMD unit using a lunar prodigy DXA system (Lunar Corp., Madison, WI). Data on body mass index (BMI), clinical biochemistry variables including serum 25-hydroxyvitamin D were collected. The Beck Depression Inventory was administered for depression purposes. RESULTS: Out of 1650 women 1182 women agreed to participate in the study (71.6%). The mean age and standard deviation (SD) of the menopausal age were 48.71 +/- 2.96 with depressed and 50.20 +/- 3.22 without depressed (P Descriptors Links Book Title Database Publisher Data Source Authors Bener,A., Saleh,N.M., Bhugra,D. Original/Translated Title URL Date of Electronic PMCID PMC4943122 Editors

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