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Ebola virus disease outbreak - Nigeria, July-September 2014 2014
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Print(0)
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Journal Article
Periodical, Full
MMWR.Morbidity and mortality weekly report
Periodical, Abbrev.
MMWR Morb.Mortal.Wkly.Rep.
Pub Date Free Form
3-Oct
Volume
63
Issue
39
Start Page
867
Other Pages
872
Notes
JID: 7802429; ppublish
Place of Publication
United States
ISSN/ISBN
1545-861X; 0149-2195
Accession Number
PMID: 25275332
Language
eng
SubFile
Journal Article; IM
DOI
mm6339a5 [pii]
Output Language
Unknown(0)
PMID
25275332
Abstract
On July 20, 2014, an acutely ill traveler from Liberia arrived at the international airport in Lagos, Nigeria, and was confirmed to have Ebola virus disease (Ebola) after being admitted to a private hospital. This index patient potentially exposed 72 persons at the airport and the hospital. The Federal Ministry of Health, with guidance from the Nigeria Centre for Disease Control (NCDC), declared an Ebola emergency. Lagos, (pop. 21 million) is a regional hub for economic, industrial, and travel activities and a setting where communicable diseases can be easily spread and transmission sustained. Therefore, implementing a rapid response using all available public health assets was the highest priority. On July 23, the Federal Ministry of Health, with the Lagos State government and international partners, activated an Ebola Incident Management Center as a precursor to the current Emergency Operations Center (EOC) to rapidly respond to this outbreak. The index patient died on July 25; as of September 24, there were 19 laboratory-confirmed Ebola cases and one probable case in two states, with 894 contacts identified and followed during the response. Eleven patients with laboratory-confirmed Ebola had been discharged, an additional patient was diagnosed at convalescent stage, and eight patients had died (seven with confirmed Ebola; one probable). The isolation wards were empty, and 891 (all but three) contacts had exited follow-up, with the remainder due to exit on October 2. No new cases had occurred since August 31, suggesting that the Ebola outbreak in Nigeria might be contained. The EOC, established quickly and using an Incident Management System (IMS) to coordinate the response and consolidate decision making, is largely credited with helping contain the Nigeria outbreak early. National public health emergency preparedness agencies in the region, including those involved in Ebola responses, should consider including the development of an EOC to improve the ability to rapidly respond to urgent public health threats.
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Authors
Shuaib,F., Gunnala,R., Musa,E.O., Mahoney,F.J., Oguntimehin,O., Nguku,P.M., Nyanti,S.B., Knight,N., Gwarzo,N.S., Idigbe,O., Nasidi,A., Vertefeuille,J.F., Centers for Disease Control and Prevention (CDC)
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Importation and containment of Ebola virus disease - Senegal, August-September 2014 2014
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
MMWR.Morbidity and mortality weekly report
Periodical, Abbrev.
MMWR Morb.Mortal.Wkly.Rep.
Pub Date Free Form
3-Oct
Volume
63
Issue
39
Start Page
873
Other Pages
874
Notes
JID: 7802429; EIN: MMWR Morb Mortal Wkly Rep. 2014 Oct 3;63(39):875; ppublish
Place of Publication
United States
ISSN/ISBN
1545-861X; 0149-2195
Accession Number
PMID: 25275333
Language
eng
SubFile
Journal Article; IM
DOI
mm6339a6 [pii]
Output Language
Unknown(0)
PMID
25275333
Abstract
On August 29, 2014, Senegal confirmed its first case of Ebola virus disease (Ebola) in a Guinean man, aged 21 years, who had traveled from Guinea to Dakar, Senegal, in mid-August to visit family. Senegalese medical and public health personnel were alerted about this patient after public health staff in Guinea contacted his family in Senegal on August 27. The patient had been admitted to a referral hospital in Senegal on August 26. He was promptly isolated, and a blood sample was sent for laboratory confirmation; Ebola was confirmed by reverse transcriptase-polymerase chain reaction at Institut Pasteur Dakar on August 29. The patient's mother and sister had been admitted to an Ebola treatment unit in Guinea on August 26, where they had named the patient as a contact and reported his recent travel to Senegal. Ebola was likely transmitted to the family from the brother of the patient, who had traveled by land from Sierra Leone to Guinea in early August seeking treatment from a traditional healer. The brother died in Guinea on August 10; family members, including the patient, participated in preparing the body for burial.
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Data Source
Authors
Mirkovic,K., Thwing,J., Diack,P.A., Centers for Disease Control and Prevention (CDC)
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Smoke and mirrors: the perils of water-pipe smoking and implications for Western countries 2014
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Chest
Periodical, Abbrev.
Chest
Pub Date Free Form
Oct
Volume
146
Issue
4
Start Page
875
Other Pages
876
Notes
JID: 0231335; CON: Chest. 2014 Oct;146(4):924-31. PMID: 24557573; ppublish
Place of Publication
United States
ISSN/ISBN
1931-3543; 0012-3692
Accession Number
PMID: 25287994
Language
eng
SubFile
Comment; Editorial; AIM; IM
DOI
10.1378/chest.14-0603 [doi]
Output Language
Unknown(0)
PMID
25287994
Abstract
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Book Title
Database
Publisher
Data Source
Authors
Leung,J.M., Sin,D.D.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Quinacrine inhibits Candida albicans growth and filamentation at neutral pH 2014 Section of Infectious Diseases, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA.; Section of Infectious Diseases, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA Division of Infectious Diseases, University of New
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Antimicrobial Agents and Chemotherapy
Periodical, Abbrev.
Antimicrob.Agents Chemother.
Pub Date Free Form
Dec
Volume
58
Issue
12
Start Page
7501
Other Pages
7509
Notes
LR: 20151029; CI: Copyright (c) 2014; GR: K12 GM088021/GM/NIGMS NIH HHS/United States; JID: 0315061; 0 (Antifungal Agents); 0 (Antiprotozoal Agents); 0 (Drug Combinations); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL
Place of Publication
United States
ISSN/ISBN
1098-6596; 0066-4804
Accession Number
PMID: 25288082
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1128/AAC.03083-14 [doi]
Output Language
Unknown(0)
PMID
25288082
Abstract
Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in part due to its strong propensity to form biofilms. Drug repurposing is an approach that might identify agents that are able to overcome antifungal drug resistance within biofilms. Quinacrine (QNC) is clinically active against the eukaryotic protozoan parasites Plasmodium and Giardia. We sought to investigate the antifungal activity of QNC against C. albicans biofilms. C. albicans biofilms were incubated with QNC at serially increasing concentrations (4 to 2,048 mug/ml) and assessed using a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay in a static microplate model. Combinations of QNC and standard antifungals were assayed using biofilm checkerboard analyses. To define a mechanism of action, QNC was assessed for the inhibition of filamentation, effects on endocytosis, and pH-dependent activity. High-dose QNC was effective for the prevention and treatment of C. albicans biofilms in vitro. QNC with fluconazole had no interaction, while the combination of QNC and either caspofungin or amphotericin B demonstrated synergy. QNC was most active against planktonic growth at alkaline pH. QNC dramatically inhibited filamentation. QNC accumulated within vacuoles as expected and caused defects in endocytosis. A tetracycline-regulated VMA3 mutant lacking vacuolar ATPase (V-ATPase) function demonstrated increased susceptibility to QNC. These experiments indicate that QNC is active against C. albicans growth in a pH-dependent manner. Although QNC activity is not biofilm specific, QNC is effective in the prevention and treatment of biofilms. QNC antibiofilm activity likely occurs via several independent mechanisms: vacuolar alkalinization, inhibition of endocytosis, and impaired filamentation. Further investigation of QNC for the treatment and prevention of biofilm-related Candida CR-BSI is warranted.
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Database
Publisher
American Society for Microbiology. All Rights Reserved
Data Source
Authors
Kulkarny,V.V., Chavez-Dozal,A., Rane,H.S., Jahng,M., Bernardo,S.M., Parra,K.J., Lee,S.A.
Original/Translated Title
URL
Date of Electronic
20141006
PMCID
PMC4249548
Editors
Receptivity to e-cigarette marketing, harm perceptions, and e-cigarette use 2015 University of Hawaii Cancer Center, Honolulu, HI, USA. ppokhrel@cc.hawaii.edu.; University of Hawaii Cancer Center, Honolulu, HI, USA.; University of Hawaii Cancer Center, Honolulu, HI, USA.; University of Hawaii Manoa Health Services, Honolulu, HI, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
American Journal of Health Behavior
Periodical, Abbrev.
Am.J.Health Behav.
Pub Date Free Form
Jan
Volume
39
Issue
1
Start Page
121
Other Pages
131
Notes
LR: 20160524; GR: P20 RR011091/RR/NCRR NIH HHS/United States; JID: 9602338; NIHMS781339; OID: NLM: NIHMS781339; OID: NLM: PMC4877176; ppublish
Place of Publication
United States
ISSN/ISBN
1945-7359; 1087-3244
Accession Number
PMID: 25290604
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.5993/AJHB.39.1.13 [doi]
Output Language
Unknown(0)
PMID
25290604
Abstract
OBJECTIVE: To test whether exposure and receptivity to e-cigarette marketing are associated with recent e-cigarette use among young adults through increased beliefs that e-cigarettes are less harmful than cigarettes. METHODS: Data were collected from 307 multiethnic 4- and 2-year college students; approximately equal proportions of current, never, and former cigarette smokers [mean age = 23.5 (SD = 5.5); 65% female]. RESULTS: Higher receptivity to e-cigarette marketing was associated with perceptions that e-cigarettes are less harmful than cigarettes, which in turn, were associated with higher recent e-cigarette use. CONCLUSIONS: The findings provide preliminary support to the proposition that marketing of e-cigarettes as safer alternatives to cigarettes or cessation aids is associated with increased e-cigarette use among young adults. The findings have implications for development of e-cigarette regulations.
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Database
Publisher
Data Source
Authors
Pokhrel,P., Fagan,P., Kehl,L., Herzog,T.A.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4877176
Editors
Is waterpipe smoking becoming increasingly widespread among the youth? 2014 Department of Pediatric Nursing, Division of Nursing, School of Health Sciences, SakaryaUniversity, Sakarya, Turkey E-mail : ndede@sakarya.edu.tr.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Asian Pacific journal of cancer prevention : APJCP
Periodical, Abbrev.
Asian Pac.J.Cancer.Prev.
Pub Date Free Form
Volume
15
Issue
18
Start Page
8005
Other Pages
8006
Notes
JID: 101130625; ppublish
Place of Publication
Thailand
ISSN/ISBN
1513-7368; 1513-7368
Accession Number
PMID: 25292104
Language
eng
SubFile
Letter; IM
DOI
Output Language
Unknown(0)
PMID
25292104
Abstract
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Cinar,N., Cakmak,V.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Legionella spp., amoebae and not-fermenting Gram negative bacteria in an Italian university hospital water system 2014 Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy.; Italian National Research Council, Institute for Coastal Marine Environment, Messina, Italy.; Department of Biomedical Sciences and Morphological and
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annals of Agricultural and Environmental Medicine : AAEM
Periodical, Abbrev.
Ann.Agric.Environ.Med.
Pub Date Free Form
Volume
21
Issue
3
Start Page
489
Other Pages
493
Notes
JID: 9500166; ppublish
Place of Publication
Poland
ISSN/ISBN
1898-2263; 1232-1966
Accession Number
PMID: 25292115
Language
eng
SubFile
Journal Article; IM
DOI
10.5604/12321966.1120623 [doi]
Output Language
Unknown(0)
PMID
25292115
Abstract
INTRODUCTION: In hospital and other health care facilities, contamination of water systems by potentially infectious microorganisms, such as bacteria, viruses and protozoa, is a source of nosocomial infections, which may originate fromcolonization of water pipes, cooling towers, spa pools, taps, showers and water supplies. Objective. The study focuses on the occurrence of Legionella spp., free-living amoebae and non-fermenting Gram-negative microorganisms in a University hospital water system located in the town of Messina (Sicily, Italy), which had never been examined previously. MATERIALS AND METHODS: From January 2008 - March 2009, hot tap water samples were collected from 10 wards. Legionella spp. recovered on selective culture medium were identified by microagglutination latex test; free-living amoebae were cultured using Escherichia coli as a food source. Non-fermenting Gram negative microorganisms were identified by API 20 NE strips. RESULTS: Legionella spp. were found in 33.33% of the samples. L. pneumophila serogroup 1 was recovered from the Laboratory Diagnostic and Anaesthesia-Neurology Wards, with a peak of 3.5 x 10(4) cfu/L in May 2008. L. pneumophila serogroups 2-14 were found in the Othorhinolaryngology, Pathologic Anatomy, Paediatrics and Surgery Wards, and peaked (4 x 10(4) cfu/L) in April 2008. Pseudomonadaceae and Hyphomycetes were also detected. Legionella spp. were recovered from samples positive for non-pathogenic amoebae Hartmannella spp. CONCLUSION: This first study of a Messina hospital water system suggested potential health risks related to the detection of Hartmannella spp., as reservoirs for Legionella spp., and Pseudomonas aeruginosa, a Gram negative non-fermenting bacterium frequently causing nosocomial pneumonia. The urgent need for monitoring programmes and prevention measures to ensure hospital water safety is stressed.
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Publisher
Data Source
Authors
Lagana,P., Caruso,G., Piccione,D., Gioffre,M.E., Pino,R., Delia,S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
The global epidemiology of waterpipe smoking 2015 Department of Epidemiology, Florida International University, Miami, Florida, USA Syrian Center for Tobacco Studies, Aleppo, Syria.; Department of Epidemiology, Florida International University, Miami, Florida, USA.; Department of Epidemiology, Florida In
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tobacco control
Periodical, Abbrev.
Tob.Control
Pub Date Free Form
Mar
Volume
24 Suppl 1
Issue
Start Page
i3
Other Pages
i12
Notes
LR: 20150423; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; GR: R01 DA035160/DA/NIDA NIH HHS/United States; GR: R
Place of Publication
England
ISSN/ISBN
1468-3318; 0964-4563
Accession Number
PMID: 25298368
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Review; IM
DOI
10.1136/tobaccocontrol-2014-051903 [doi]
Output Language
Unknown(0)
PMID
25298368
Abstract
OBJECTIVES: In the past decade, waterpipe smoking (a.k.a. hookah, shisha, narghile) has become a global phenomenon. In this review, we provide an updated picture of the main epidemiological trends in waterpipe smoking globally. DATA SOURCES: Peer-reviewed publications indexed in major biomedical databases between 2004 and 2014. Search keywords included a combination of: waterpipe, hookah, shisha along with epidemiology, patterns, prevalence and predictors. We also used different spellings of waterpipe terms commonly used. STUDY SELECTION: The focus was on studies with large representative samples, national data or high-quality reports that illuminated aspects of the epidemiology and trends in waterpipe smoking. DATA EXTRACTION: Multiple researchers extracted the data independently and collectively decided on the most important and pertinent studies to include in the review. DATA SYNTHESIS: Waterpipe smoking has become a global phenomenon among youth. The global waterpipe epidemic is likely driven by (1) the introduction of manufactured flavoured tobacco (Maassel); (2) the intersection between waterpipe's social dimension and thriving cafe culture; (3) the evolution of mass communication media; (4) the lack of regulatory/policy framework specific to the waterpipe. Waterpipe smoking is becoming the most popular tobacco use method among youth in the Middle East, and is quickly gaining popularity elsewhere. Important patterns of waterpipe smoking include the predominance among younger, male, high socioeconomic, and urban groups. Intermittent and social use are also noted patterns. CONCLUSIONS: Waterpipe smoking has become a global public health problem. Developing surveillance, intervention and regulatory/policy frameworks specific to the waterpipe has become a public health priority.
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Database
Publisher
Data Source
Authors
Maziak,W., Taleb,Z.B., Bahelah,R., Islam,F., Jaber,R., Auf,R., Salloum,R.G.
Original/Translated Title
URL
Date of Electronic
20141008
PMCID
PMC4345835
Editors
Assessment of ebola virus disease, health care infrastructure, and preparedness - four counties,Southeastern Liberia, august 2014 2014
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
MMWR.Morbidity and mortality weekly report
Periodical, Abbrev.
MMWR Morb.Mortal.Wkly.Rep.
Pub Date Free Form
10-Oct
Volume
63
Issue
40
Start Page
891
Other Pages
893
Notes
JID: 7802429; ppublish
Place of Publication
United States
ISSN/ISBN
1545-861X; 0149-2195
Accession Number
PMID: 25299605
Language
eng
SubFile
Journal Article; IM
DOI
mm6340a3 [pii]
Output Language
Unknown(0)
PMID
25299605
Abstract
Ebola virus disease (Ebola) is a multisystem disease caused by a virus of the genus Ebolavirus. In late March 2014, Ebola cases were described in Liberia, with epicenters in Lofa County and later in Montserrado County. While information about case burden and health care infrastructure was available for the two epicenters, little information was available about remote counties in southeastern Liberia. Over 9 days, August 6-14, 2014, Ebola case burden, health care infrastructure, and emergency preparedness were assessed in collaboration with the Liberian Ministry of Health and Social Welfare in four counties in southeastern Liberia: Grand Gedeh, Grand Kru, River Gee, and Maryland. Data were collected by health care facility visits to three of the four county referral hospitals and by unstructured interviews with county and district health officials, hospital administrators, physicians, nurses, physician assistants, and health educators in all four counties. Local burial practices were discussed with county officials, but no direct observation of burial practices was conducted. Basic information about Ebola surveillance and epidemiology, case investigation, contact tracing, case management, and infection control was provided to local officials.
Descriptors
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Database
Publisher
Data Source
Authors
Forrester,J.D., Pillai,S.K., Beer,K.D., Neatherlin,J., Massaquoi,M., Nyenswah,T.G., Montgomery,J.M., De Cock,K., Centers for Disease Control and Prevention (CDC)
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Respiratory effects in children from passive smoking of cigarettes and narghile: ISAAC Phase Three in Syria 2014 National Research Center for Chronic Respiratory Diseases, Tishreen University School of Medicine, Lattakia, Syria.; National Research Center for Chronic Respiratory Diseases, Tishreen University School of Medicine, Lattakia, Syria.; National Research Cen
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Periodical, Abbrev.
Int.J.Tuberc.Lung Dis.
Pub Date Free Form
Nov
Volume
18
Issue
11
Start Page
1279
Other Pages
1284
Notes
LR: 20151119; JID: 9706389; 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
France
ISSN/ISBN
1815-7920; 1027-3719
Accession Number
PMID: 25299858
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.5588/ijtld.13.0912 [doi]
Output Language
Unknown(0)
PMID
25299858
Abstract
BACKGROUND: The association between environmental tobacco smoke (ETS) and asthma symptoms is well documented, but a causal relationship is inconclusive. International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three was the first to report a dose-response relationship between current wheezing and exposure to parental cigarette smoke. As exposure of children to water pipe (narghile) smoke is of concern in Syria, in the ISAAC Phase Three Tartous Centre we also examined the role of parental smoking of the narghile. METHODS: Parents of children aged 6-7 years completed core written questionnaires about the prevalence of symptoms, and an environmental questionnaire for other risk factors, including parental cigarette smoking. We added questions about narghile to the questionnaire. RESULTS: Among 2 734 pupils (49% females) surveyed, we found an association between exposure to ETS of the mother smoking cigarette or narghile and ever wheezing, nocturnal cough and severe wheeze; however, the strongest association was found when the mother smoked narghile. Mother smoking narghile was also associated with exercise wheeze. Father smoking narghile, but not cigarettes, was associated with nocturnal cough, severe wheeze and exercise wheeze. The association with current wheeze became significant when mother smoked both cigarettes and narghile; however, the effect was addititive and not synergic. CONCLUSION: We recommend that international studies investigating ETS include questions on narghile smoking.
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Database
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Data Source
Authors
Mohammad,Y., Shaaban,R., Hassan,M., Yassine,F., Mohammad,S., Tessier,J.F., Ellwood,P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors