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WTS Database
The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title | Pub Year | Author | SearchLink Sort descending |
|---|---|---|---|
| Personal tobacco pack display before and after the introduction of plain packaging with larger pictorial health warnings in Australia: an observational study of outdoor cafe strips | 2014 | Cancer Council Victoria, Melbourne, Vic., Australia. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Addiction (Abingdon, England)
Periodical, Abbrev.
Addiction
Pub Date Free Form
Apr
Volume
109
Issue
4
Start Page
653
Other Pages
662
Notes
CI: (c) 2014; JID: 9304118; CIN: Addiction. 2014 May;109(5):704-5. PMID: 24720825; OTO: NOTNLM; 2013/07/16 [received]; 2013/10/13 [revised]; 2013/12/17 [accepted]; 2014/02/25 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1360-0443; 0965-2140
Accession Number
PMID: 24428427
Language
eng
SubFile
Journal Article; Observational Study; Research Support, Non-U.S. Gov't; IM
DOI
10.1111/add.12466 [doi]
Output Language
Unknown(0)
PMID
24428427
Abstract
AIMS: We tested whether prevalence of cigarette pack display and smoking at outdoor venues and pack orientation changed following the introduction of plain packaging and larger pictorial health warnings in Australia. METHODS: Between October and April 2011-12 (pre-plain packaging, pre-PP) and 2012-13 (post-plain packaging, post-PP), we counted patrons, smokers and tobacco packs at cafes, restaurants and bars with outdoor seating. Pack type (fully branded, plain or unknown) and orientation were noted. Rates of pack display, smoking and pack orientation were analysed using multi-level Poisson regression. RESULTS: Pack display declined by 15% [adjusted incident rate ratio (IRR) = 0.85, 95% confidence interval (CI) = 0.79-0.91, P
Descriptors
Links
Book Title
Database
Publisher
Society for the Study of Addiction
Data Source
Authors
Zacher,M., Bayly,M., Brennan,E., Dono,J., Miller,C., Durkin,S., Scollo,M., Wakefield,M.
Original/Translated Title
URL
Date of Electronic
20140225
PMCID
Editors
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| A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia | 2015 | Department of Surgery, Trinity Center for Health Sciences, St. James's Hospital and Trinity College Dublin, Dublin, Ireland. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E
Periodical, Abbrev.
Dis.Esophagus
Pub Date Free Form
Feb-Mar
Volume
28
Issue
2
Start Page
121
Other Pages
126
Notes
CI: (c) 2014; JID: 8809160; Adenocarcinoma Of Esophagus; OTO: NOTNLM; 2014/01/15 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1442-2050; 1120-8694
Accession Number
PMID: 24428806
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1111/dote.12166 [doi]
Output Language
Unknown(0)
PMID
24428806
Abstract
Barrett's esophagus (BE) arising from chronic gastro-oesophageal reflux (GERD) is the main pathologic precursor of esophageal adenocarcinoma (EAC). The risk of progression to high-grade dysplasia (HGD) and EAC is unclear, and recent population studies from Denmark and Northern Ireland suggest that this has been overestimated in the past. No data exist from the Republic of Ireland. A detailed clinical, endoscopic, and pathologic database was established in one center as a proposed pilot for a national registry, and initial and follow-up data were abstracted by a data manager. One thousand ninety-three patients were registered, 60 patients with HGD were excluded, leaving 1033, with a median age of 59 and 2 : 1 male to female ratio, and 3599 person-years of follow-up. The overall incidence of HGD/EAC was 1.33% per year overall, 0.85% if the first year is excluded. Within the first year after index endoscopy, 18 cases of HGD or EAC were identified, and 30 following the first year. Low-grade dysplasia (LGD) on index endoscopy was associated with an incidence of progression of 6.5% per year, and 3.1% when tertiary referrals were excluded. These data provide important demographic and clinical information on the population of Irish patients with BE, with incidence rates of progression higher than recently published population-based registry series, perhaps relating to sampling and pathological assessment. Low-grade dysplasia on initial biopsy is a significant proxy marker of risk of progression.
Descriptors
Links
Book Title
Database
Publisher
International Society for Diseases of the Esophagus
Data Source
Authors
Picardo,S.L., O'Brien,M.P., Feighery,R., O'Toole,D., Ravi,N., O'Farrell,N.J., O'Sullivan,J.N., Reynolds,J.V.
Original/Translated Title
URL
Date of Electronic
20140115
PMCID
Editors
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| Early adolescent patterns of alcohol, cigarettes, and marijuana polysubstance use and young adult substance use outcomes in a nationally representative sample | 2014 | National Institute on Alcohol Abuse and Alcoholism, United States. Electronic address: psych.hmossmd@gmail.com.; Alcohol Epidemiologic Data System, CSR, Incorporated, United States.; Alcohol Epidemiologic Data System, CSR, Incorporated, United States. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Drug and alcohol dependence
Periodical, Abbrev.
Drug Alcohol Depend.
Pub Date Free Form
1-Mar
Volume
136
Issue
Start Page
51
Other Pages
62
Notes
CI: Published by Elsevier Ireland Ltd.; JID: 7513587; OTO: NOTNLM; 2013/07/30 [received]; 2013/12/09 [revised]; 2013/12/14 [accepted]; 2013/12/31 [aheadofprint]; ppublish
Place of Publication
Ireland
ISSN/ISBN
1879-0046; 0376-8716
Accession Number
PMID: 24434016
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1016/j.drugalcdep.2013.12.011 [doi]
Output Language
Unknown(0)
PMID
24434016
Abstract
BACKGROUND: Alcohol, tobacco and marijuana are the most commonly used drugs by adolescents in the U.S. However, little is known about the patterning of early adolescent substance use, and its implications for problematic involvement with substances in young adulthood. We examined patterns of substance use prior to age 16, and their associations with young adult substance use behaviors and substance use disorders in a nationally representative sample of U.S. adolescents. METHOD: Using data from Wave 4 of the Add Health Survey (n=4245), we estimated the prevalence of various patterns of early adolescent use of alcohol, cigarettes, and marijuana use individually and in combination. Then we examined the effects of patterns of early use of these substances on subsequent young adult substance use behaviors and DSM-IV substance use disorders. RESULTS: While 34.4% of individuals reported no substance use prior to age 16, 34.1% reported either early use of both alcohol and marijuana or alcohol, marijuana and cigarettes, indicating the relatively high prevalence of this type of polysubstance use behavior among U.S. adolescents. Early adolescent use of all three substances was most strongly associated with a spectrum of young adult substance use problems, as well as DSM-IV substance use disorder diagnoses. CONCLUSIONS: This research confirms the elevated prevalence and importance of polysubstance use behavior among adolescents prior to age 16, and puts early onset of alcohol, marijuana and cigarette use into the context of use patterns rather than single drug exposures.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Moss,H.B., Chen,C.M., Yi,H.Y.
Original/Translated Title
URL
Date of Electronic
20131231
PMCID
Editors
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| In vitro effect of amphotericin B on Candida albicans, Candida glabrata and Candida parapsilosis biofilm formation | 2014 | Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 9 Maria Sklodowska-Curie Street, 85-094, Bydgoszcz, Poland, malgorzata_szabelska@wp.pl. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Mycopathologia
Periodical, Abbrev.
Mycopathologia
Pub Date Free Form
Feb
Volume
177
Issue
2-Jan
Start Page
19
Other Pages
27
Notes
JID: 7505689; 0 (Antifungal Agents); 7XU7A7DROE (Amphotericin B); 2013/08/02 [received]; 2014/01/06 [accepted]; 2014/01/17 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1573-0832; 0301-486X
Accession Number
PMID: 24436013
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1007/s11046-014-9727-7 [doi]
Output Language
Unknown(0)
PMID
24436013
Abstract
Candida spp. biofilm is considered highly resistant to conventional antifungals. The aim of this study was to investigate the in vitro effect of amphotericin B on Candida spp. biofilms at different stages of maturation. We investigated the activity of amphotericin B against 78 clinical isolates of Candida spp., representing three species, growing as planktonic and sessile cells, by a widely accepted broth microdilution method. The in vitro effect on sessile cell viability was evaluated by MTT reduction assay. All examined strains were susceptible to amphotericin B when grown as free-living cells. At the early stages of biofilm maturation 96.7-100.0 % strains, depending on species, displayed amphotericin B sessile minimal inhibitory concentration (SMIC) = 1 mug/mL. Mature Candida spp. biofilm of 32.1-90.0 % strains displayed amphotericin B SMIC = 1 mug/mL. Based on these results, amphotericin B displays species- and strain-depending activity against Candida spp. biofilms.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Prazynska,M., Gospodarek,E.
Original/Translated Title
URL
Date of Electronic
20140117
PMCID
Editors
|
|||
| Multiple tobacco product use among adults in the United States: cigarettes, cigars, electronic cigarettes, hookah, smokeless tobacco, and snus | 2014 | RTI International, Public Health Research Division, Research Triangle Park, NC 27709, USA. Electronic address: younlee@rti.org.; RTI International, Public Health Research Division, Research Triangle Park, NC 27709, USA.; RTI International, Public Health R | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Preventive medicine
Periodical, Abbrev.
Prev.Med.
Pub Date Free Form
May
Volume
62
Issue
Start Page
14
Other Pages
19
Notes
LR: 20151119; CI: Copyright (c) 2014; JID: 0322116; OTO: NOTNLM; 2013/08/19 [received]; 2014/01/09 [revised]; 2014/01/12 [accepted]; 2014/01/16 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1096-0260; 0091-7435
Accession Number
PMID: 24440684
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1016/j.ypmed.2014.01.014 [doi]
Output Language
Unknown(0)
PMID
24440684
Abstract
OBJECTIVE: Noncigarette tobacco products are increasingly popular. Researchers need to understand multiple tobacco product use to assess the effects of these products on population health. We estimate national prevalence and examine risk factors for multiple product use. METHOD: We calculated prevalence estimates of current use patterns involving cigarettes, cigars, electronic cigarettes, hookah, smokeless tobacco, and snus using data from the 2012 RTI National Adult Tobacco Survey (N=3627), a random-digit-dial telephone survey of adults aged 18 and over. Associations between use patterns (exclusive single product and multiple products) and demographic characteristics were examined using Pearson chi-square tests and logistic regression. RESULTS: 32.1% of adults currently use 1 or more tobacco products; 14.9% use cigarettes exclusively, and 6.6% use one noncigarette product exclusively, 6.9% use cigarettes with another product (dual use), 1.3% use two noncigarette products, and 2.4% use three or more products (polytobacco use). Smokers who are young adult, male, never married, reside in the West, and made prior quit attempts were at risk for multiple product use. CONCLUSIONS: Over 10% of U.S. adults use multiple tobacco products. A better understanding of multiple product use involving combustible products, like cigars and hookah, is needed. Multiple product use may be associated with past quit attempts.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Inc
Data Source
Authors
Lee,Y.O., Hebert,C.J., Nonnemaker,J.M., Kim,A.E.
Original/Translated Title
URL
Date of Electronic
20140116
PMCID
Editors
|
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| Animal rennets as sources of dairy lactic acid bacteria | 2014 | Department of Agricultural and Forest Science, Universita degli Studi di Palermo, Palermo, Italy. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Applied and Environmental Microbiology
Periodical, Abbrev.
Appl.Environ.Microbiol.
Pub Date Free Form
Apr
Volume
80
Issue
7
Start Page
2050
Other Pages
2061
Notes
LR: 20150515; GENBANK/KF286609; GENBANK/KF286610; GENBANK/KF286611; GENBANK/KF286612; GENBANK/KF286613; GENBANK/KF286614; GENBANK/KF286615; GENBANK/KF286616; GENBANK/KF286617; GENBANK/KF286618; GENBANK/KF826008; GENBANK/KF826009; GENBANK/KF826010; GENBANK
Place of Publication
United States
ISSN/ISBN
1098-5336; 0099-2240
Accession Number
PMID: 24441167
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1128/AEM.03837-13 [doi]
Output Language
Unknown(0)
PMID
24441167
Abstract
The microbial composition of artisan and industrial animal rennet pastes was studied by using both culture-dependent and -independent approaches. Pyrosequencing targeting the 16S rRNA gene allowed to identify 361 operational taxonomic units (OTUs) to the genus/species level. Among lactic acid bacteria (LAB), Streptococcus thermophilus and some lactobacilli, mainly Lactobacillus crispatus and Lactobacillus reuteri, were the most abundant species, with differences among the samples. Twelve groups of microorganisms were targeted by viable plate counts revealing a dominance of mesophilic cocci. All rennets were able to acidify ultrahigh-temperature-processed (UHT) milk as shown by pH and total titratable acidity (TTA). Presumptive LAB isolated at the highest dilutions of acidified milks were phenotypically characterized, grouped, differentiated at the strain level by randomly amplified polymorphic DNA (RAPD)-PCR analysis, and subjected to 16S rRNA gene sequencing. Only 18 strains were clearly identified at the species level, as Enterococcus casseliflavus, Enterococcus faecium, Enterococcus faecalis, Enterococcus lactis, Lactobacillus delbrueckii, and Streptococcus thermophilus, while the other strains, all belonging to the genus Enterococcus, could not be allotted into any previously described species. The phylogenetic analysis showed that these strains might represent different unknown species. All strains were evaluated for their dairy technological performances. All isolates produced diacetyl, and 10 of them produced a rapid pH drop in milk, but only 3 isolates were also autolytic. This work showed that animal rennet pastes can be sources of LAB, mainly enterococci, that might contribute to the microbial diversity associated with dairy productions.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Cruciata,M., Sannino,C., Ercolini,D., Scatassa,M.L., De Filippis,F., Mancuso,I., La Storia,A., Moschetti,G., Settanni,L.
Original/Translated Title
URL
Date of Electronic
20140117
PMCID
PMC3993140
Editors
|
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| Factors influencing tobacco use treatment patterns among Vietnamese health care providers working in community health centers | 2014 | Department of Population Health, New York University School of Medicine, 227 East 30th Street, New York, NY 10016, USA. donna.shelley@nyumc.org. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC public health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
22-Jan
Volume
14
Issue
Start Page
68
Other Pages
2458-14-68
Notes
LR: 20150515; JID: 100968562; OID: NLM: PMC3902028; 2013/07/03 [received]; 2013/12/13 [accepted]; 2014/01/22 [aheadofprint]; epublish
Place of Publication
England
ISSN/ISBN
1471-2458; 1471-2458
Accession Number
PMID: 24450865
Language
eng
SubFile
Journal Article; IM
DOI
10.1186/1471-2458-14-68 [doi]
Output Language
Unknown(0)
PMID
24450865
Abstract
BACKGROUND: Almost half of adult men in Viet Nam are current smokers, a smoking prevalence that is the second highest among South East Asian countries (SEAC). Although Viet Nam has a strong public health delivery system, according to the 2010 Global Adult Tobacco Survey, services to treat tobacco dependence are not readily available to smokers. The purpose of this study was to characterize current tobacco use treatment patterns among Vietnamese health care providers and factors influencing adherence to guideline recommended tobacco use screening and cessation interventions. METHODS: A cross sectional survey of 134 health care providers including physicians, nurses, midwives, physician assistants and pharmacists working in 23 community health centers in Viet Nam. RESULTS: 23% of providers reported screening patients for tobacco use, 33% offered advice to quit and less than 10% offered assistance to half or more of their patients in the past three months. Older age, attitudes, self-efficacy and normative beliefs were associated with screening for tobacco use. Normative beliefs were associated with offering advice to quit. However in the logistic regression analysis only normative beliefs remained significant for both screening and offering advice to quit. Over 90% of providers reported having never received training related to tobacco use treatment. Major barriers to treating tobacco use included lack of training, lack of referral resources and staff to support counseling, and lack of patient interest. CONCLUSIONS: Despite ratifying the FCTC, Viet Nam has not made progress in implementing policies and systems to ensure that smokers are receiving evidence-based treatment. This study suggests a need to change organizational norms through changes in national policies, training and local system-level changes that facilitate treatment.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Shelley,D., Tseng,T.Y., Pham,H., Nguyen,L., Keithly,S., Stillman,F., Nguyen,N.
Original/Translated Title
URL
Date of Electronic
20140122
PMCID
PMC3902028
Editors
|
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| Legionella contamination in hospitals of the Campania Region: five years of environmental surveillance results | 2014 | Dipartimento di Scienze Mediche Preventive, Universita degli Studi di Napoli "Federico II", Italy.; Dipartimento di Scienze Mediche Preventive, Universita degli Studi di Napoli "Federico II", Italy.; Dipartimento di Scienze Mediche Preventive, Universita | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annali di Igiene : Medicina Preventiva e di Comunita
Periodical, Abbrev.
Ann.Ig.
Pub Date Free Form
Jan-Feb
Volume
26
Issue
1
Start Page
89
Other Pages
96
Notes
JID: 9002865; ppublish
Place of Publication
Italy
ISSN/ISBN
1120-9135; 1120-9135
Accession Number
PMID: 24452187
Language
eng
SubFile
Journal Article; IM
DOI
10.7416/ai.2014.1961 [doi]
Output Language
Unknown(0)
PMID
24452187
Abstract
OBJECTIVE: The purpose of this study was to assess the presence and the distribution of Legionella serotypes in 50 hospital facilities in the Campania Region (Italy) through the sampling of their waters. METHODS: From January 2008 to December 2012, in compliance with the Italian Monitoring Guidelines for Legionellosis, 4.842 water samples were collected from the end points of hot water distribution networks, air conditioning systems, boilers and cooling towers. RESULTS: 1.426 (29.4%) of the 4.842 samples resulted positive for Legionella spp, with a bacterial average of 3.40 log10 cfu/L. The frequency of Legionella isolation in the specimens progressively decreased during the study (43.8% in 2008 vs 22.9% in 2012). Samples from cooling towers (32.7%), showers and taps (31.9%) revealed a more frequent presence of the microorganism, although considerable bacterial concentration variability was found in all examined points. A bacterial average of 3.33 + 0.88 log10 cfu/L was detected in cooling towers, whereas the lowest values (2.89 + 0.92 cfu/L) were found in ACSs. The most frequently isolated species were L. pneumophila 2-14, detected in 60.6% of positive samples. Within serotypes, types 6 (23.8%), 8 (21.9%) and 3 (21.4%) resulted as being the most representative. CONCLUSIONS: A significant contamination was found in examined centers. It is therefore advisable to systematically implement currently available surveillance and monitoring strategies through the scrupulous monitoring of systems as well as through the application of validated and effective procedures.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Torre,I., Diana,M.V., Iervolino,C., Borriello,T., Imperato,O.C., Maccarino,S., Pennino,F.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
|
|||
| 3-Isopropyl-1-{2-[(1-methyl-1H-tetra-zol-5-yl)sulfan-yl]acet-yl}-2,6-di-phenyl-pi peridin-4-one hemihydrate | 2013 | Research Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhinganallur, Chennai 600 119, India ; Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India.; Centre of Advanced Study in Crystallography and Biophysics, | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
2-Oct
Volume
69
Issue
Pt 11
Start Page
o1598
Other Pages
Notes
LR: 20140127; JID: 101089178; OID: NLM: PMC3884276; 2013/11/01 [ecollection]; 2013/09/04 [received]; 2013/09/25 [accepted]; 2013/10/02 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 24454052
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536813026500 [doi]
Output Language
Unknown(0)
PMID
24454052
Abstract
In the title compound, C24H27N5O2S.0.5H2O, the piperidine ring adopts a distorted boat conformation. The phenyl rings subtend dihedral angles of 69.7 (1) and 88.7 (1) degrees with the best plane through the piperidine moiety. In the crystal, symmetry-related mol-ecules are linked through a network of C-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredN inter-actions, the former connecting them into zigzag chains along the c-axis direction and the latter forming an R (2) 2(4)motif. The dimer formation (C-Hcdots, three dots, centeredN) and the repetition of symmetry-related molecules (C-Hcdots, three dots, centeredO) along the b-axis direction stabilize the packing mode. The water mol-ecule is located on a twofold rotation axis.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Ganesan,S., Sugumar,P., Ananthan,S., Ponnuswamy,M.N.
Original/Translated Title
URL
Date of Electronic
20131002
PMCID
PMC3884276
Editors
|
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| 5-Acetyl-4-(3-hy-droxy-phen-yl)-6-methyl-1,2,3,4-tetra-hydro-pyrimidin-2-one-tris -(hy-droxy-meth-yl)ammonium chloride (2/1) | 2013 | PG & Research Department of Chemistry, The New College (Autonomous), Chennai 600 014, Tamilnadu, India.; PG & Research Department of Chemistry, The New College (Autonomous), Chennai 600 014, Tamilnadu, India.; Department of Physics, The New College (Auton | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
13-Nov
Volume
69
Issue
Pt 12
Start Page
o1766
Other Pages
7
Notes
LR: 20140127; JID: 101089178; OID: NLM: PMC3885040; 2013/12/01 [ecollection]; 2013/10/28 [received]; 2013/11/07 [accepted]; 2013/11/13 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 24454216
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536813030559 [doi]
Output Language
Unknown(0)
PMID
24454216
Abstract
The asymmetric unit of the title compound, 2C13H14N2O3.C3H10NO3 (+).Cl(-), contains two independent mol-ecules (A and B) of the title pyrimidine derivative and one ion-pair of tris-(hy-droxy-meth-yl)ammonium chloride. The pyrimidine ring in each pyrimidine derivative has a half-chair conformation. Its mean plane is inclined to the benzene ring by 87.2 (3) degrees in mol-ecule A and 85.7 (2) degrees in mol-ecule B. In the crystal, the pyrimidine derivatives are connected to each other by N-Hcdots, three dots, centeredO hydrogen bonds, forming chains propagating along the b-axis direction. The chains are linked via O-H-Cl hydrogen bonds, forming corrugated sheets lying parallel to the bc plane. The sheets are linked via C-Hcdots, three dots, centeredO hydrogen bonds, forming a three-dimensional framework. The tris-(hy-droxy-meth-yl)ammonium chloride mol-ecules are located in the cages of the framework. There are also further C-Hcdots, three dots, centeredO hydrogen bonds and C-Hcdots, three dots, centeredpi inter-actions present in the three-dimensional framework structure. Both the cation and chloride anion of the tris-(hy-droxy-meth-yl)ammonium chloride ion pair are disordered over two positions, with a refined occupancy ratio of 0.418 (8):0.582 (8) for the cation and 0.71 (4):0.29 (4) for the anion.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Huq,C.A., Fouzia,S., Nizammohideen,M.
Original/Translated Title
URL
Date of Electronic
20131113
PMCID
PMC3885040
Editors
|
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