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N-{2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]eth-yl}pyridin-2-amine monohydrate 2010 Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China.
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Print(0)
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Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
23-Jun
Volume
66
Issue
Pt 7
Start Page
o1727
Other Pages
Notes
LR: 20111209; JID: 101089178; OID: NLM: PMC3006790; 2010/05/27 [received]; 2010/06/14 [accepted]; 2010/06/23 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 21587944
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536810022816 [doi]
Output Language
Unknown(0)
PMID
21587944
Abstract
In the title compound, C(18)H(24)N(4)O.H(2)O, the piperizine ring adopts a chair conformation and the dihedral angle between the phenyl and pyridine rings is 39.9 (3) degrees . The comformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are +anti-periplanar. An intra-molecular C-Hcdots, three dots, centeredO inter-action occurs. In the crystal, the water mol-ecule links the mol-ecules into chains through O-Hcdots, three dots, centeredN hydrogen bonds. Weak N-Hcdots, three dots, centeredO, C-Hcdots, three dots, centeredN and C-Hcdots, three dots, centeredO inter-actions further stabilize the crystal structure.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Jiang,Q. F., Lu,C. X.
Original/Translated Title
URL
Date of Electronic
20100623
PMCID
PMC3006790
Editors
(2S)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-(4-hy-droxy-phen-yl)acetic acid 2010 Department of Chemistry, Shandong Normal University, Jinan 250014, People's Republic of China.
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Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
3-Jul
Volume
66
Issue
Pt 8
Start Page
o1907
Other Pages
8
Notes
LR: 20111209; JID: 101089178; OID: NLM: PMC3007271; 2010/05/31 [received]; 2010/06/28 [accepted]; 2010/07/03 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 21588240
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536810025262 [doi]
Output Language
Unknown(0)
PMID
21588240
Abstract
There are two mol-ecules in the asymmetric unit of the title compound, C(15)H(17)N(3)O(6). The 2,3-dioxopiperazine ring adopts a half-chair conformation with torsion angles of -7.6 (4) and 35.1 (4) degrees in one mol-ecule, and 5.3 (4) and 45.4 (4) degrees in the other mol-ecule. In the crystal structure, the carb-oxy groups are involved in classical inversion-related O-Hcdots, three dots, centeredO hydrogen bonds, which link the mol-ecules into centrosymmetric dimers. These dimers are further linked by inter-molecular O-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds. Each independent mol-ecule also exhibits an intra-molecular N-Hcdots, three dots, centeredO hydrogen bond. The H atoms of the carb-oxy groups are disordered over two positions, with refined site-occupancy factors of 0.5.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Wang,Q., Hu,L., Ma,J. P., Guo,D. S.
Original/Translated Title
URL
Date of Electronic
20100703
PMCID
PMC3007271
Editors
(E)-N'-(3,3-Dimethyl-2,6-diphenyl-piperidin-4-yl-idene)isonicotinohydrazide 2010
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Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
20-Oct
Volume
66
Issue
Pt 11
Start Page
o2841
Other Pages
Notes
LR: 20111209; JID: 101089178; OID: NLM: PMC3009086; 2010/10/10 [received]; 2010/10/12 [accepted]; 2010/10/20 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 21589027
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536810040936 [doi]
Output Language
Unknown(0)
PMID
21589027
Abstract
In the title mol-ecule, C(25)H(26)N(4)O, the piperidine ring adopts a chair conformation, with the plane through the four coplanar atoms making dihedral angles of 84.76 (6), 82.28 (5) and 81.91 (6) degrees with the pyridine-ring and the phenyl rings at the 2 and 6 positions, respectively. The pyridine ring makes dihedral angles of 64.13 (8) and 10.75 (8) degrees with the phenyl rings at the 2 and 6 positions, respectively. The dihedral angle between the two phenyl rings is 53.57 (8) degrees . The phenyl rings and one of the methyl groups at position 3 have an equatorial orientation. In the crystal, mol-ecules are linked by N-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Sankar,C., Pandiarajan,K., Thiruvalluvar,A., Gayathri,P.
Original/Translated Title
URL
Date of Electronic
20101020
PMCID
PMC3009086
Editors
11-[(E)-Benzyl-idene]-14-hy-droxy-8-phenyl-3,13-diaza-hepta-cyclo-[13.7.1.1.0.0.0 .0]tetra-cosa-1(22),15,17,19(23),20-pentaen-10-one 2010
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
6-Nov
Volume
66
Issue
Pt 12
Start Page
o3045
Other Pages
Notes
LR: 20111209; JID: 101089178; OID: NLM: PMC3011470; 2010/10/22 [received]; 2010/10/27 [accepted]; 2010/11/06 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 21589358
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536810043874 [doi]
Output Language
Unknown(0)
PMID
21589358
Abstract
In the title compound, C(35)H(30)N(2)O(2), the piperidine ring adopts a chair conformation and the pyrrolidine ring adopts an envelope conformation. The naphthalene ring makes dihedral angles of 24.56 (3) and 36.13 (4) degrees with the terminal phenyl rings. The dihedral angle between the two terminal phenyl rings is 55.27 (5) degrees . One of the C atoms in the pyrrolidine ring is disordered over two sites, with a refined occupany ratio of 0.670 (3):0.330 (3). An intra-molecular O-Hcdots, three dots, centeredN hydrogen bond generates an S(6) ring. In the crystal structure, inversion dimers linked by pairs of C-Hcdots, three dots, centeredO hydrogen bonds generate R(2) (2)(18) loops within sheets of mol-ecules lying parallel to the bc plane.
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Database
Publisher
Data Source
Authors
Kumar,R. S., Osman,H., Abdul Rahim,A. S., Hemamalini,M., Fun,H. K.
Original/Translated Title
URL
Date of Electronic
20101106
PMCID
PMC3011470
Editors
Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy 2011 Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. jean-francois.etter@unige.ch
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Print(0)
Ref Type
Journal Article
Periodical, Full
Addiction (Abingdon, England)
Periodical, Abbrev.
Addiction
Pub Date Free Form
Nov
Volume
106
Issue
11
Start Page
2017
Other Pages
2028
Notes
LR: 20151119; CI: (c) 2011 The Authors, Addiction (c) 2011; JID: 9304118; 6M3C89ZY6R (Nicotine); CIN: Addiction. 2011 Nov;106(11):2029-30. PMID: 21978314; 2011/07/27 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1360-0443; 0965-2140
Accession Number
PMID: 21592253
Language
eng
SubFile
Journal Article; IM
DOI
10.1111/j.1360-0443.2011.03505.x [doi]
Output Language
Unknown(0)
PMID
21592253
Abstract
AIMS: To assess the profile, utilization patterns, satisfaction and perceived effects among users of electronic cigarettes ('e-cigarettes'). DESIGN AND SETTING: Internet survey in English and French in 2010. MEASUREMENTS: Online questionnaire. PARTICIPANTS: Visitors of websites and online discussion forums dedicated to e-cigarettes and to smoking cessation. FINDINGS: There were 3587 participants (70% former tobacco smokers, 61% men, mean age 41 years). The median duration of electronic cigarette use was 3 months, users drew 120 puffs/day and used five refills/day. Almost all (97%) used e-cigarettes containing nicotine. Daily users spent $33 per month on these products. Most (96%) said the e-cigarette helped them to quit smoking or reduce their smoking (92%). Reasons for using the e-cigarette included the perception that it was less toxic than tobacco (84%), to deal with craving for tobacco (79%) and withdrawal symptoms (67%), to quit smoking or avoid relapsing (77%), because it was cheaper than smoking (57%) and to deal with situations where smoking was prohibited (39%). Most ex-smokers (79%) feared they might relapse to smoking if they stopped using the e-cigarette. Users of nicotine-containing e-cigarettes reported better relief of withdrawal and a greater effect on smoking cessation than those using non-nicotine e-cigarettes. CONCLUSIONS: E-cigarettes were used much as people would use nicotine replacement medications: by former smokers to avoid relapse or as an aid to cut down or quit smoking. Further research should evaluate the safety and efficacy of e-cigarettes for administration of nicotine and other substances, and for quitting and relapse prevention.
Descriptors
Links
Book Title
Database
Publisher
Society for the Study of Addiction
Data Source
Authors
Etter,J.F., Bullen,C.
Original/Translated Title
URL
Date of Electronic
20110727
PMCID
Editors
Modifying effect of suicidal ideation on the relationship between asthma and cigarette use behaviors among Korean adolescents 2011 Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of preventive medicine and public health = Yebang Uihakhoe chi
Periodical, Abbrev.
J.Prev.Med.Public.Health.
Pub Date Free Form
May
Volume
44
Issue
3
Start Page
118
Other Pages
124
Notes
LR: 20150204; JID: 101242972; OID: NLM: PMC3249247; ppublish
Place of Publication
Korea (South)
ISSN/ISBN
2233-4521; 1975-8375
Accession Number
PMID: 21617337
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.3961/jpmph.2011.44.3.118 [doi]
Output Language
Unknown(0)
PMID
21617337
Abstract
OBJECTIVES: Although cigarette smoking is known to be related to the exacerbation of asthma symptoms, several studies have indicated that the prevalence of cigarette smoking among asthmatic adolescents is similar to or even higher than that among non-asthmatic adolescents. The aim of this study was to evaluate the relationship between asthma and cigarette use behaviors and whether or not the presence of suicidal ideation modifies this relationship among Korean adolescents. METHODS: We analyzed data from the 2008 Korea Youth Risk Behavior Web-based Survey, which included a nationally representative sample of middle and high school students. Multiple logistic regression models were used to calculate odd ratios and 95% confidence intervals of cigarette use behaviors among current asthmatics, former asthmatics, and non-asthmatics, after adjusting for gender, grade, school records, socioeconomic status, current alcohol use, and suicidal ideation. RESULTS: Of 75 238 study participants, 3.5% were current asthmatics and 4.5% were former asthmatics. Compared with non-asthmatics, asthmatics were more likely to report current cigarette use, frequent and heavy cigarette use, and cigarette use before 13 years of age. There were statistically significant interactions between asthma and suicidal ideation in cigarette use behaviors. CONCLUSIONS: This study demonstrated that asthmatic adolescents are more likely than non-asthmatic adolescents to engage in cigarette use behaviors and the presence of suicidal ideation is an effect modifier of the relationship between asthma and cigarette use behaviors. Particular attention should be paid to the awareness of health risks of cigarette smoking and mental health problems among asthmatic adolescents.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Bae,J., Park,E.Y., Park,S.W.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC3249247
Editors
Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY 2011 Department of Earth and Environmental Sciences, University of Texas at Arlington, Arlington, TX 76019-0049, USA. hunt@uta.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environment international
Periodical, Abbrev.
Environ.Int.
Pub Date Free Form
Oct
Volume
37
Issue
7
Start Page
1196
Other Pages
1205
Notes
LR: 20131121; CI: Copyright (c) 2011; JID: 7807270; 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); K5161X06LL (Cotinine); 2010/11/25 [received]; 2011/04/21 [accepted]; 2011/05/28 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1873-6750; 0160-4120
Accession Number
PMID: 21620473
Language
eng
SubFile
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1016/j.envint.2011.04.013 [doi]
Output Language
Unknown(0)
PMID
21620473
Abstract
The Syracuse, NY, AUDIT (Assessment of Urban Dwellings for Indoor Toxics) study was designed to quantify asthma agent levels in the inner-city homes of a birth cohort whose mothers had a diagnosis of asthma. Risk of exposure to particulate matter (PM), particle number and tobacco smoke was assessed in 103 infants' homes. Repeat measurements were made in 44% of the homes. Infants also were examined on a quarterly basis during the first year of life to monitor their respiratory health and urine cotinine levels. Overall geometric mean (GM) values for PM(2.5) of 21.2 mug/m(3) and for PM(10) of 31.8 mug/m(3) were recorded in homes at visit 1. GM values for PM(2.5) and PM(10) in smoking homes were higher at 26.3 and 37.7 mug/m(3), while values in non-smoking homes were 12.7 and 21.2 mug/m(3) respectively. Fifty-four percent of mothers (55/103) smoked at some point in pregnancy (39% smoked throughout pregnancy). Environmental tobacco smoke (ETS) exposure occurred in 68% of homes during the infants' first year. Significant to this study was the size- and time-resolved monitoring of PM at 140 home visits and the classification of PM count data. PM number counts ranged from continuously low levels (little indoor activity) to continuously high counts (constant indoor activity), and recorded apparent instances of prolonged repeated cigarette smoking. Wheezing in the first year of life was recorded for 38% of the infants (39/103). Adjusted logistic regression modeling demonstrated that elevated levels of indoor PM(2.5) (>/= 15 mug/m(3)) were a significant risk factor for infant wheezing after controlling for infant gender, mothers' age and education level, season of home visit and presence of carpeting (OR 4.21; 95% CI 1.36-13.03; p=0.013). An elevated level of the nicotine metabolite cotinine in infant urine also was associated with infant wheezing after adjusting for infant gender, mothers' age and education level (OR 5.10; 95% CI 0.96-27.24; p=0.057). ETS exposure was pervasive in the AUDIT cohort and a risk for developing infants in this urban population.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Hunt,A., Crawford,J.A., Rosenbaum,P.F., Abraham,J.L.
Original/Translated Title
URL
Date of Electronic
20110528
PMCID
Editors
Air contamination due to smoking in German restaurants, bars, and other venues--before and after the implementation of a partial smoking ban 2011 Unit Cancer Prevention and WHO Collaborating Centre for Tobacco Control, German Cancer Research Center, Heidelberg, Germany.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Nov
Volume
13
Issue
11
Start Page
1155
Other Pages
1160
Notes
LR: 20150204; JID: 9815751; 0 (Hazardous Substances); 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); OID: NLM: PMC3203133; 2011/05/26 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 21622497
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ntr/ntr099 [doi]
Output Language
Unknown(0)
PMID
21622497
Abstract
INTRODUCTION: The present study examined the reduction in exposure to tobacco smoke in German hospitality venues following the implementation of a partial smoking ban by measuring the indoor air concentration of PM(2.5) in 2005 and 2009, that is, before and after the legislation was implemented. METHODS: The concentration of respirable suspended particles (PM(2.5)) in the indoor air of German hospitality venues was measured using a laser photometer (AM510). The prelegislation sample from 2005 included 80 venues of which 58 could be revisited in 2009. After replenishment, the postlegislation sample consisted of 79 venues. RESULTS: Compared with the prelegislation measurement, the concentration of PM(2.5) in hospitality venues was reduced significantly after introduction of the smoke-free legislation. The median mass concentration of PM(2.5) was reduced by 87.1% in coffee bars, by 88.7% in restaurants, by 66.3% in bars, and by 90.8% in discotheques. Notably, legal exemptions to the smoking ban are an issue: At the postlegislation measurement in 2009, the mass concentrations of PM(2.5) were substantially higher in venues allowing smoking in the whole venue or in a designated smoking room than in completely smoke-free venues. CONCLUSIONS: The German smoke-free legislation significantly reduced the levels of respirable suspended particles in the indoor air of hospitality venues, benefiting the health of employees and patrons alike. But legal exemptions attenuated the effectiveness of the policy.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Gleich,F., Mons,U., Potschke-Langer,M.
Original/Translated Title
URL
Date of Electronic
20110526
PMCID
PMC3203133
Editors
Nitrogen uptake and preference in a forest understory following invasion by an exotic grass 2011 Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA. jmf@illinois.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Oecologia
Periodical, Abbrev.
Oecologia
Pub Date Free Form
Nov
Volume
167
Issue
3
Start Page
781
Other Pages
791
Notes
LR: 20151119; JID: 0150372; 0 (Nitrogen Isotopes); N762921K75 (Nitrogen); 2010/11/08 [received]; 2011/05/12 [accepted]; 2011/05/29 [aheadofprint]; ppublish
Place of Publication
Germany
ISSN/ISBN
1432-1939; 0029-8549
Accession Number
PMID: 21625979
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1007/s00442-011-2030-0 [doi]
Output Language
Unknown(0)
PMID
21625979
Abstract
Plant-soil interactions have been proposed as a causative mechanism explaining how invasive plant species impact ecosystem processes. We evaluate whether an invasive plant influences plant and soil-microbe acquisition of nitrogen to elucidate the mechanistic pathways by which invaders might alter N availability. Using a (15)N tracer, we quantify differences in nitrogen uptake and allocation in communities with and without Microstegium vimineum, a shade-tolerant, C(4) grass that is rapidly invading the understories of eastern US deciduous forests. We further investigate if plants or the microbial biomass exhibit preferences for certain nitrogen forms (glycine, nitrate, and ammonium) to gain insight into nitrogen partitioning in invaded communities. Understory native plants and M. vimineum took up similar amounts of added nitrogen but allocated it differently, with native plants allocating primarily to roots and M. vimineum allocating most nitrogen to shoots. Plant nitrogen uptake was higher in invaded communities due primarily to the increase in understory biomass when M. vimineum was present, but for the microbial biomass, nitrogen uptake did not vary with invasion status. This translated to a significant reduction (P
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Fraterrigo,J.M., Strickland,M.S., Keiser,A.D., Bradford,M.A.
Original/Translated Title
URL
Date of Electronic
20110529
PMCID
Editors
Risk factors for nocturnal reflux in a large GERD cohort 2011 Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, MO 64128-2295, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of clinical gastroenterology
Periodical, Abbrev.
J.Clin.Gastroenterol.
Pub Date Free Form
Oct
Volume
45
Issue
9
Start Page
764
Other Pages
768
Notes
JID: 7910017; ppublish
Place of Publication
United States
ISSN/ISBN
1539-2031; 0192-0790
Accession Number
PMID: 21633310
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1097/MCG.0b013e318205e164 [doi]
Output Language
Unknown(0)
PMID
21633310
Abstract
BACKGROUND: Nocturnal gastroesophageal reflux disease (GERD) has been associated with severe complications including erosive esophagitis, peptic stricture, and even esophageal adenocarcinoma and is known to cause a decreased health-related quality of life. However, there is limited information on independent predictors of nocturnal GERD. AIM: The aim of this study was to examine the relationship between nocturnal GERD and patient demographics, symptoms, clinical and endoscopic findings. METHODS: Consecutive patients presenting to the gastrointestinal endoscopy unit for evaluation of GERD symptoms undergoing index endoscopy were asked to complete a validated GERD questionnaire. Demographics, clinical features, and endoscopic findings were recorded. Nocturnal GERD was defined as awakening at night by heartburn or acid regurgitation. Patient factors were compared using chi and Mann-Whitney U test. All factors that were statistically significant (P5 years, severe heartburn, daily regurgitation, regurgitation duration >5 years (all P5 years, severe heartburn, daily regurgitation, regurgitation duration >5 years (all P5 years [1.7 (1.2 to 2.4), P
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Gaddam,S., Maddur,H., Wani,S., Gupta,N., Singh,M., Singh,V., Moloney,B., Puli,S.R., Rastogi,A., Bansal,A., Sharma,P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors