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A closed-loop control "playback" smoking machine for generating mainstream smoke aerosols 2006 Shihadeh, A., Aerosol Research Laboratory, Department of Mechanical Engineering, American University of Beirut, Beirut, Lebanon
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Periodical, Abbrev.
J.Aerosol Med.Deposition Clear.Eff.Lung
Pub Date Free Form
2006/
Volume
19
Issue
2
Start Page
137
Other Pages
147
Notes
Place of Publication
ISSN/ISBN
0894-2684
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
A first generation smoking machine capable of reading and replicating detailed puffing behavior from recorded smoking topography data is presented. Unlike standard smoking machines, which model human puffing behavior as a steady periodic waveform with a fixed puff frequency, volume, and duration, this novel machine generates a mainstream smoke aerosol by automatically "playing-back" puff topography recordings. Because combustion chemistry is highly non-linear, representing real smoking behavior with a smoothed periodic waveform may result in a tobacco smoke aerosol with a significantly different chemical composition and physical properties than that generated by a smoker. The machine presented here utilizes a rapid closed-loop control algorithm coded in Labview® to generate smoke aerosols for toxicological assessment and inhalation studies. To illustrate its use, dry particulate matter and carbon monoxide yields generated using the playback and equivalent periodic puffing regimens are compared for a single smoking session by a 26-year-old male narghile water-pipe smoker. It was found that the periodic puffing regimen yielded 20% less carbon monoxide (CO) than the played-back smoking session, indicating that steady periodic smoking regimens, which are widely used in tobacco smoke research, may not produce realistic smoke aerosols. © Mary Ann Liebert, Inc.
Descriptors
carbon monoxide, cigarette smoke, closed loop control, tobacco smoke, unclassified drug, water, accuracy, aerosol, algorithm, devices, article, combustion, control system, inhalation, machine, measurement, particulate matter, recording, smoking, smoking machine, tube, waveform, Labview
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Shihadeh,A., Azar,S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
A portable, low-resistance puff topography instrument for pulsating, high-flow smoking devices. 2005 Shihadeh, A., Department of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Behavior research methods
Periodical, Abbrev.
Behav Res Methods
Pub Date Free Form
/
Volume
37
Issue
1
Start Page
186
Other Pages
191
Notes
Place of Publication
ISSN/ISBN
1554-351X
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
A smoking topography instrument appropriate for pulsating high flow rate smoking devices, such as the narghile water pipe, has been developed and tested. Instrument precision and repeatability was determined using a digitally controlled smoking machine, and the added draw resistance due to the topography instrument was measured over the range of expected puff flow rates. The maximum error in any topography variable was found to be less than 5%. The instrument was successfully demonstrated in a pilot field study of 30 volunteer narghile smokers. The pilot study yielded an average smoker puff volume, duration, and interpuff interval of 0.531, 2.47 sec, 16.28 sec, respectively.
Descriptors
article, artifact, computer graphics, equipment design, flow kinetics, human, information processing, devices, Lebanon, lung ventilation, mathematical computing, nebulizer, pathophysiology, physiology, pilot study, pressure transducer, signal processing, smoking, tobacco dependence
Links
Book Title
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Shihadeh,A., Antonios,C., Azar,S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Towards a topographical model of narghile water-pipe café smoking: A pilot study in a high socioeconomic status neighborhood of Beirut, Lebanon 2004 Shihadeh, A., Department of Mechanical Engineering, American University of Beirut, P.O. Box 11-0236, Riad El S., Beirut, Lebanon
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Pharmacology Biochemistry and Behavior
Periodical, Abbrev.
Pharmacol.Biochem.Behav.
Pub Date Free Form
/
Volume
79
Issue
1
Start Page
75
Other Pages
82
Notes
Place of Publication
ISSN/ISBN
0091-3057
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
A pilot study of narghile water-pipe smokers in a cafe in the Hamra neighborhood of Beirut, Lebanon, was conducted to develop a preliminary model of narghile water-pipe smoking behavior for use in laboratory smoking machine studies. The model is based on data gathered from smoking sessions of 30 min or longer duration from 52 smoker volunteers using a differential pressure puff topography instrument, as well as anonymous visual observations of 56 smokers in the same cafe. Results showed that the "average" water-pipe cafe smoking session consists of one hundred seventy-one 530-ml puffs of 2.6-s duration at a frequency of 2.8 puffs/min. The implications of this comparatively high-intensity puffing regimen on the production of toxic smoke constituents are discussed. © 2004 Elsevier Inc. All rights reserved.
Descriptors
adult, article, behavior, comparative study, female, human, devices, laboratory, Lebanon, male, pilot study, priority journal, smoking, social status, topography
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Shihadeh,A., Azar,S., Antonios,C., Haddad,A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Investigation of mainstream smoke aerosol of the argileh water pipe 2003 Shihadeh, A., Department of Mechanical Engineering, American University of Beirut, Riad El-Solh, Beirut 1107 2020, Lebanon
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Food and Chemical Toxicology
Periodical, Abbrev.
Food Chem.Toxicol.
Pub Date Free Form
2003/01
Volume
41
Issue
1
Start Page
143
Other Pages
152
Notes
Place of Publication
ISSN/ISBN
0278-6915
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
A first-generation smoking machine and protocol have been developed in order to study the mainstream smoke aerosol and elucidate thermal-fluid processes of the argileh water pipe. Results using a common mo'assel tobacco mixture show that, contrary to popular perceptions, the mainstream smoke contains significant amounts of nicotine, "tar" and heavy metals. With a standard smoking protocol of 100 puffs of 3 s duration spaced at 30-s intervals, the following results were obtained in a single smoking session: 2.25 mg nicotine, 242 mg nicotine-free dry particulate matter (NFDPM), and relative to the smoke of a single cigarette, high levels of arsenic, chromium and lead. It was found that increasing puff frequency increased the NFDPM but had little effect on nicotine delivery, while removing the water from the bowl increased by several-fold the nicotine, but had little effect on NFDPM. It was also found that the charcoal disk heat source contributed less than 2% of total particulate matter (TPM), and that characteristic temperatures of the tobacco varied from 450°C nearest the heat source to 50°C furthest away, indicating that the NFDPM is likely a result of devolatilization rather than chemical reaction, and will thus differ significantly in composition from that of cigarette smoke. © 2003 Elsevier Science Ltd. All rights reserved.
Descriptors
arsenic, charcoal, chromium, cigarette smoke, heavy metal, lead, nicotine, tar, tobacco smoke, water, aerosol, article, chemical composition, controlled study, heat, human, liquid, machine, particulate matter, smoking, temperature, thermal analysis, tobacco, tube, volatilization
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Shihadeh,A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Cocaine free base abuse: A new smoking disorder 1992 Siegel, R.K., Psychiatry/Biobehavioral Sci. Dept., UCLA School of Medicine, Los Angeles, CA, United States
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of psychoactive drugs
Periodical, Abbrev.
J.PSYCHOACT.DRUGS
Pub Date Free Form
1992/
Volume
24
Issue
2
Start Page
193
Other Pages
212
Notes
Place of Publication
ISSN/ISBN
0279-1072
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Vapors were once thought to be exhalations of body organs (such as the stomach), which affected the physical and mental state of a person. Early American pioneers frequently blamed almost any muscle ache, pain or fever on 'the vapors.' Mental depression, hysterical nervous conditions and other psychological illnesses were all attributed to the elusive vapors. It seemed logical that to cure maladies caused by the exhalation of vapors one simply inhaled medicinal agents in the form of gases or fumes. In so doing, the American pioneers were repeating a form of traditional medicine that is as old as humanity itself. The history of vapors and their curative powers can be traced to both Old and New World practices. In the Old World, the ancient Sumerians, Egyptians and Greeks, among others, employed the vapors of marijuana, opium and carbon dioxide. In the New World, early South and North Americans burned tobacco and coca. Nearly everywhere these practices spread, local cultures embellished the vapors with their own plant drugs. Three such practices remain today: the smoking of tobacco, opium and coca. The Spaniards introduced tobacco smoking to the Philippine Islands from where it spread to China at the beginning of the seventeenth century. The Chinese, finding the tobacco somewhat unpleasant, mixed various substances with it including arsenic, marijuana and opium. The Persians, also finding it unpleasant, passed the smoke through water and developed early versions of water pipes. By the end of the seventeenth century, tobacco dipped in opium was commonly used in Java. This custom spread to Formosa and then back to China. Gradually, the Chinese faded out the tobacco and began smoking opium alone and this practice became widespread by the end of the eighteenth century. The Chinese refined the opium preparations and a concentrated paste of crude opium became the preferred form. The paste was heated and the smoke or vapors were inhaled. Enormous doses were sometimes smoked, doses that would produce certain death if taken orally or by a nontolerant user (Kane 1882). Since those early beginnings, opium has captured the romantic imagination, bodies and minds of people across the planet. Yet, as historian A.R. Neligan (1927: 34) points out, opium takes a far tighter hold of an individual than all other drugs except cocaine. Cocaine vapors shared a similar association with tobacco smoking in its South American genesis. The magico-religious uses of tobacco burning and smoking, the sacrificial burning of coca leaves, the inhalations of tobacco smoke to cure disease, the medicinal inhalation of vapors from burning coca seeds, and the chewing of mixtures of tobacco and coca leaves were all common events in the early history of that area. Eventually a crude coca paste was mixed with tobacco and smoked. As the practice spread to North America, the tobacco was gradually eliminated. Innovative pioneer alchemists in the United States in the twentieth century have refined the coca paste into a purified alkaloid more suitable for smoking. Called cocaine free base, the product is heated in water pipes and the smoke or vapors are inhaled. Like the opium vapors, enormous doses of cocaine are sometimes inhaled: doses that have produced lethal effects when administered via other routes. The resultant practice of cocaine smoking has become a new fad. But smoking vapors of cocaine is like the phantasms the word 'vapors' suggests: a foolish and fanciful, albeit fashionable, notion. It may also lead to a potentially toxic and dependence-producing disorder. THE COCAINE SMOKING DISORDER: The major findings of this monograph present evidence for a new substance mental disorder, the Cocaine Smoking Disorder. The diagnostic criteria for this disorder are: A. Recent use of cocaine via smoking of the free base (or coca paste). B. At least two of the following psychological symptoms within less than one hour of smoking cocaine: 1. psychomotor agitatio
Descriptors
cocaine, adult, article, clinical article, drug abuse, female, hallucination, human, interview, male, myalgia, paranoia, psychosocial disorder, violence, visual impairment
Links
Book Title
Database
Embase
Publisher
Data Source
Embase
Authors
Siegel,R. K.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Effect of temperature and pipe material on biofilm formation and survival of Escherichia coli in used dinking water pipes: A laboratory-based study 2006 Silhan, J., Institute of Environment and Resources, Technical University of Denmark, 2800 Lyngby, Denmark
Source Type
Print(0)
Ref Type
Generic
Periodical, Full
Water Science and Technology
Periodical, Abbrev.
Water Sci. Technol.
Pub Date Free Form
2006/
Volume
54
Issue
3
Start Page
49
Other Pages
56
Notes
Place of Publication
ISSN/ISBN
0273-1223
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Segments of used drinking water pipes of galvanised steel (GS), cross-linked polyethylene (PEX), copper pipes (Cu) or new medium-density polyethylene (PE) were investigated for the formation of biofilm and survival of E. coli in biofilm and in the water phase. Pipes were filled with water and incubated at 15°C or 35°C under static conditions. Biofilm formation was followed during 32, 40 and 56 (58) d. The most dense biofilm was formed on GS, reaching approximately 4.7 × 105 CFU/ cm2 measured as heterotrophic plate count (HPC), and at the other materials the density reached 3 × 103CFU/cm2 on PE and PEX and 5 × 101 and 5 × 102 CFU/cm2 on Cu pipes after 58 d at 15°C. Biofilm HPC values were higher at 35°C than at 15°C, with only slightly higher values on the metals, but 100-fold higher on PE and PEX. Adenosine triphosphate (ATP) measurements confirmed the general trends observed by HPC. Higher temperature was seen to be an important factor reducing E. coli survival in the water phase in drinking water pipes. At 15°C E. coli survived more than 4 d in GS and Cu pipes and 8 d in PE pipes, but was not detected after 48 h at 35°C. The E. coli survived longer at both temperatures in the glass control bottles than in the drinking water pipes. Despite the obvious biofilm formation, E coli was not detected in the biofilm at any of the investigated surfaces. © IWA Publishing 2006.
Descriptors
adenosine triphosphate, copper, drinking water, polyethylene, steel, article, bacterial count, bacterial survival, biofilm, controlled study, Escherichia coli, heterotrophy, high temperature, incubation temperature, laboratory test, nonhuman, pipeline, temperature dependence, water contamination, water supply
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Silhan,J., Corfitzen,C. B., Albrechtsen,H. J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Emerging frontiers in detection and control of bacterial biofilms 2014 Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore 637551, Singapore; Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Interdisciplinary Graduate School, Nanyang Technolog
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Current opinion in biotechnology
Periodical, Abbrev.
Curr.Opin.Biotechnol.
Pub Date Free Form
Apr
Volume
26
Issue
Start Page
1
Other Pages
6
Notes
CI: Copyright (c) 2013; JID: 9100492; 2013/05/25 [received]; 2013/08/02 [revised]; 2013/08/07 [accepted]; 2013/08/31 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1879-0429; 0958-1669
Accession Number
PMID: 24679251
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.1016/j.copbio.2013.08.002 [doi]
Output Language
Unknown(0)
PMID
24679251
Abstract
Bacteria form surface-attached biofilm communities in nature. In contrast to free-living cells, bacterial cells within biofilms resist sanitizers and antimicrobials. While building biofilms, cells physiologically adapt to sustain the otherwise lethal impacts of a variety of environmental stress conditions. In this development, the production and embedding of cells in extracellular polymeric substances plays a key role. Biofilm bacteria can cause a range of problems to food processing including reduced heat-cold transfer, clogging water pipelines, food spoilage and they may cause infections among consumers. Recent biofilm investigations with the aim of potential control approaches include a combination of bacterial genetics, systems biology, materials and mechanic engineering and chemical biology.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Tan,S.Y., Chew,S.C., Tan,S.Y., Givskov,M., Yang,L.
Original/Translated Title
URL
Date of Electronic
20130831
PMCID
Editors
Epidemiological investigation of an outbreak of viral hepatitis 2006 Singh, P.M.P., Station Health Organisation, Devlali, India
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Medical Journal Armed Forces India
Periodical, Abbrev.
Med.J.Armed Forces India
Pub Date Free Form
2006/10
Volume
62
Issue
4
Start Page
332
Other Pages
334
Notes
Place of Publication
ISSN/ISBN
0377-1237; 0377-1237
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Background: There was a rise in the number of viral hepatitis cases in a regimental training centre in Mar 2003 and an epidemic of viral hepatitis was suspected. Methods: The clinical case sheets and preliminary investigations carried out in the local military hospital (MH) were reviewed. A cross sectional descriptive epidemiological study was undertaken with survey odf the suspected sewage and water pipelines. Results: A total of 36 cases occurred from Mar 2003 to Apr 2003. There was clustering in time and space suggesting common source epidemic. All the 36 serum samples tested for IgM anti HEV antibodies were positive. Exploration of the water pipelines revealed sewage contamination due to leakage in the pipeline passing close to the sewage line. The overall attack rate was 1.44%. Conclusion: The outbreak of viral hepatitis in the regimental training centre occurred due to sewage contamination of drinking water pipeline.
Descriptors
drinking water, hepatitis E antigen, immunoglobulin M antibody, antibody detection, article, blood sampling, descriptive research, epidemic, human, medical record review, pipeline, public hospital, sewage, time series analysis, viral contamination, virus hepatitis, water contamination, water supply
Links
Book Title
Database
Embase
Publisher
Data Source
Embase
Authors
Singh,P. M. P., Handa,B. S. K., Banerjee,A.
Original/Translated Title
URL
http://medind.nic.in/maa/t06/i4/maat06i4p332.pdf
Date of Electronic
PMCID
Editors
Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids 2003 Sinzinger, H., Inst. Diagn./Treatm. Lipid D., A-1090 Vienna, Austria
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Life Sciences
Periodical, Abbrev.
Life Sci.
Pub Date Free Form
2003/11
Volume
74
Issue
1
Start Page
47
Other Pages
53
Notes
Place of Publication
ISSN/ISBN
0024-3205
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
The biological effects of smoking water pipe on haemostasis and the eicosanoid system is unknown. Water pipe smoking is familiar to approximately 1 billion people around the world. Considering this quite impressive number, we investigated the potential effect of smoking the Narghile on oxidation injury by monitoring parameters of the (iso)eicosanoid system. Patients were allowed to smoke a water pipe once daily for 14 days. Blood was drawn from 7 healthy adult non-cigarette smoking male volunteers before and immediately after the first smoking of the water pipe and additionally after 6 hours. One and 2 weeks thereafter, blood was drawn again before and after smoking. A total of 7 blood samples was drawn during the study, and parameters of in vivo oxidation injury (8-epi-PGF2α, malondialdehyde [MDA]) and haemostasis (11-dehydro-thromboxane B2 [11-DH-TXB2]) were investigated. A single smoking session increased oxidation injury (8-epi-PGF2α: p = 0.03; MDA: p = 0.001) and 11-DH-TXB 2 (p = 0.00003) significantly, and repeated daily smoking induced a persistent long-lasting oxidation injury reflected by elevated prevalues but a smaller response to the actual water pipe smoke. These findings indicate a significant increase of in vivo oxidative stress by regular water pipe smoking. © 2003 Elsevier Inc. All rights reserved.
Descriptors
11 oxothromboxane B2, 8 isoprostaglandin E2, icosanoid, malonaldehyde, article, blood sampling, smoking, controlled study, electric potential, hemostasis, human, human experiment, in vivo study, male, normal human, oxidation, thrombocyte function
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Wolfram,R. M., Chehne,F., Oguogho,A., Sinzinger,H.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Water pipe network - future strategy detection and prevention of external corrosion in Zurich 1994 Skarda, B.C., Zurich Water Supply, 8023 Zurich, Switzerland
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Water Supply
Periodical, Abbrev.
Water Supply
Pub Date Free Form
1994/
Volume
12
Issue
4-Mar
Start Page
139
Other Pages
150
Notes
Place of Publication
ISSN/ISBN
0735-1917
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
The water pipe network is the most important capital investment of any water supply. Every 20-25 years, the actual condition of the pipe network will be examined and assessed, and miscellaneous causes of damage investigated and determined. The long-term future pipe network strategy of a water supply enterprise comprises both network extension and conservation of existing assets by means of systematic preventive maintenance and consequent replacement. long-term financial planning should be based on replacement rates that take into account the interdependence between pressure conditions, drinking water quality, water losses, damage frequency, age of pipe network, durability of pipe material, construction cost increase, and coordination of the underground infrastructure, as well as profitability and supply image. The annual repair costs amounting to approx. 7% of the Zurich Water Supply turnover are too high. External corrosion/settlement, which is responsible for 90% of the 600-800 damaged pipes, is attributed to the combined effect of corrosion currents from tramlines, reinforced concrete structures and macro-elements. These are accelerated by aggressive, partly water-saturated heterogeneous soils and galvanic compounds, mainly earthing installations. Countermeasures are comprised in the Zurich Pipe Network Strategy and in the long-term financial plan. Only the best pipe network material is good enough. 'Who believes in the future also relies on the future!'
Descriptors
drinking water, capital, city planning, conference paper, corrosion, cost, investment, pressure, protection, soil, Switzerland, tube, turnover time, water quality, water supply
Links
Book Title
Database
Embase
Publisher
Data Source
Embase
Authors
Skarda,B. C.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors