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WTS Database
The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title | Pub Year | Author | SearchLink Sort ascending |
|---|---|---|---|
| Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B | 2014 | Laboratorio Especial de Micologia, Disciplina de Infectologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.; Laboratorio Especial de Micologia, Disciplina de Infectologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil; Departamento | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
PloS one
Periodical, Abbrev.
PLoS One
Pub Date Free Form
31-Oct
Volume
9
Issue
10
Start Page
e109553
Other Pages
Notes
LR: 20151029; JID: 101285081; 0 (Antifungal Agents); 0 (DNA, Ribosomal); 0 (Triazoles); 7XU7A7DROE (Amphotericin B); OID: NLM: PMC4215839; 2014 [ecollection]; 2014/05/09 [received]; 2014/07/30 [accepted]; 2014/10/31 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1932-6203; 1932-6203
Accession Number
PMID: 25360765
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1371/journal.pone.0109553 [doi]
Output Language
Unknown(0)
PMID
25360765
Abstract
Invasive infections caused by Trichosporon spp. have increased considerably in recent years, especially in neutropenic and critically ill patients using catheters and antibiotics. The genus presents limited sensitivity to different antifungal agents, but triazoles are the first choice for treatment. Here, we investigated the biofilm production and antifungal susceptibility to triazoles and amphotericin B of 54 Trichosporon spp. isolates obtained from blood samples (19), urine (20) and superficial mycosis (15). All isolates and 7 reference strains were identified by sequence analysis and phylogenetic inferences of the IGS1 region of the rDNA. Biofilms were grown on 96-well plates and quantitation was performed using crystal violet staining, complemented with Scanning Electron Microscopy (SEM). Susceptibility tests for fluconazole, itraconazole, voriconazole and amphotericin B were processed using the microdilution broth method (CLSI) for planktonic cells and XTT reduction assay for biofilm-forming cells. Our results showed that T. asahii was the most frequent species identified (66.7%), followed by T. faecale (11.1%), T. asteroides (9.3%), T. inkin (7.4%), T. dermatis (3.7%) and one T. coremiiforme (1.8%). We identified 4 genotypes within T. asahii isolates (G1, G3, G4 and G5) and 2 genotypes within T. faecale (G1 and G3). All species exhibited high adhesion and biofilm formation capabilities, mainly T. inkin, T. asteroides and T. faecale. Microscopy images of high biofilm-producing isolates showed that T. asahii presented mainly hyphae and arthroconidia, whereas T. asteroides exhibited mainly short arthroconidia and few filaments. Voriconazole exhibited the best in vitro activity against all species tested. Biofilm-forming cells of isolates and reference strains were highly resistant to all antifungals tested. We concluded that levels of biofilm formation by Trichosporon spp. were similar or even greater than those described for the Candida genus. Biofilm-forming cells were at least 1,000 times more resistant to antifungals than planktonic cells, especially to voriconazole.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Iturrieta-Gonzalez,I.A., Padovan,A.C., Bizerra,F.C., Hahn,R.C., Colombo,A.L.
Original/Translated Title
URL
Date of Electronic
20141031
PMCID
PMC4215839
Editors
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| Ever Use of Nicotine and Nonnicotine Electronic Cigarettes Among High School Students in Ontario, Canada | 2015 | Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; hayley.hamilton@camh.ca.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dalla Lana S | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Oct
Volume
17
Issue
10
Start Page
1212
Other Pages
1218
Notes
CI: (c) The Author 2014; JID: 9815751; 6M3C89ZY6R (Nicotine); 2014/04/01 [received]; 2014/10/22 [accepted]; 2014/10/30 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 25358662
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ntr/ntu234 [doi]
Output Language
Unknown(0)
PMID
25358662
Abstract
INTRODUCTION: There are limited data on the use of electronic cigarettes (e-cigarettes) among youth, particularly with regard to the use of nicotine versus nonnicotine products. This study investigates ever use of nicotine and nonnicotine e-cigarettes and examines the demographic and behavioral correlates of e-cigarette use in Ontario, Canada. METHODS: Data for 2,892 high school students were derived from the 2013 Ontario Student Drug Use and Health Survey. This province-wide school-based survey is based on a 2-stage cluster design. Bivariate and multivariate analyses were used to investigate the factors associated with ever use of e-cigarettes. Ever use of e-cigarettes was derived from the question, "Have you ever smoked at least one puff from an electronic cigarette?" All analyses included appropriate adjustments for the complex study design. RESULTS: Fifteen percent of high school students reported using e-cigarettes in their lifetime. Most students who ever used e-cigarettes reported using e-cigarettes without nicotine (72%), but 28% had used e-cigarettes with nicotine. Male, White/Caucasian, and rural students, as well as those with a history of using tobacco cigarettes, were at greater odds of e-cigarette use. Seven percent of students who had never smoked a tobacco cigarette in their lifetime reported using an e-cigarette. Five percent of those who had ever used an e-cigarette had never smoked a tobacco cigarette. CONCLUSION: More students reported ever using e-cigarettes without nicotine than with nicotine in Ontario, Canada. This underscores the need for greater knowledge of the contents of both nicotine and nonnicotine e-cigarettes to better guide public health policies.
Descriptors
Links
Book Title
Database
Publisher
. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco
Data Source
Authors
Hamilton,H.A., Ferrence,R., Boak,A., Schwartz,R., Mann,R.E., O'Connor,S., Adlaf,E.M.
Original/Translated Title
URL
Date of Electronic
20141030
PMCID
Editors
|
|||
| Characterizing Concurrent Tobacco Product Use Among Homeless Cigarette Smokers | 2015 | Department of Educational Psychology, College of Education, University of Houston, Houston, TX;; Department of Educational Psychology, College of Education, University of Houston, Houston, TX; lrreitzel@uh.edu.; University of Texas School of Public Health | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Sep
Volume
17
Issue
9
Start Page
1156
Other Pages
1160
Notes
CI: (c) The Author 2014; JID: 9815751; 7U1EE4V452 (Carbon Monoxide); 2014/06/05 [received]; 2014/10/20 [accepted]; 2014/10/30 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 25358660
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ntr/ntu230 [doi]
Output Language
Unknown(0)
PMID
25358660
Abstract
INTRODUCTION: Cigarette smoking prevalence rates are high among homeless adults (>70%); however, little is known about concurrent tobacco or other nicotine product use (i.e., concurrent use [CU]) in this population. CU may impact smoking quit rates and confer greater risk of health problems within this vulnerable population. This study characterized CU in a sample of homeless smokers and compared cigarette-only smokers (C-OS) to concurrent users (CUs) on participant characteristics and factors known to be associated with smoking cessation. METHODS: Participants were 178 adult conventional cigarette smokers from a homeless shelter in Dallas, TX. Sociodemographic characteristics, number of homelessness episodes, tobacco dependence, and items characterizing use of several tobacco/nicotine products over the last 30 days including use frequency, reasons for use, and perceived health risks were described. Sociodemographic characteristics, number of homelessness episodes, tobacco dependence, stress, readiness to quit (RTQ) smoking, and number of smoking quit attempts in the last year were compared between the C-OS and CUs groups using t tests and chi-square tests. RESULTS: CU was prevalent (n = 91; 51.1%), and 49.5% of CUs reported the use of >/=2 products in addition to conventional cigarettes. Compared with C-OS, CUs were younger and had more homelessness episodes, higher expired breath carbon monoxide levels, and higher stress (ps
Descriptors
Links
Book Title
Database
Publisher
. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco
Data Source
Authors
Kish,D.H., Reitzel,L.R., Kendzor,D.E., Okamoto,H., Businelle,M.S.
Original/Translated Title
URL
Date of Electronic
20141030
PMCID
Editors
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|||
| Opinions about electronic cigarette use in smoke-free areas among U.S. Adults, 2012 | 2015 | School of Public Health, Georgia State University, Atlanta, GA bmajeed1@student.gsu.edu.; School of Public Health, Georgia State University, Atlanta, GA.; School of Public Health, Georgia State University, Atlanta, GA.; School of Public Health, Georgia St | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Jun
Volume
17
Issue
6
Start Page
675
Other Pages
681
Notes
LR: 20160715; CI: (c) The Author 2014; GR: P50 DA036128/DA/NIDA NIH HHS/United States; GR: P50DA036128/DA/NIDA NIH HHS/United States; GR: R03 CA159909/CA/NCI NIH HHS/United States; GR: R21 CA180934/CA/NCI NIH HHS/United States; JID: 9815751; OID: NLM: PMC
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 25358659
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; IM
DOI
10.1093/ntr/ntu235 [doi]
Output Language
Unknown(0)
PMID
25358659
Abstract
INTRODUCTION: In the United States, electronic cigarettes (e-cigarettes) are currently unregulated, extensively marketed, and experiencing a rapid increase in use. The purpose of this study was to examine the opinions of U.S. adults about e-cigarette use in smoke-free public areas. METHODS: Data were obtained from the online HealthStyle survey administered to a probability sample of a nationally representative online panel. The study included 4,043U.S. adults, aged 18 years or older who responded to this question, "Do you think e-cigarette should be allowed to be used in public areas where tobacco smoking is prohibited?" Multinomial logistic regression analyses were used to examine opinions on e-cigarette use in smoke-free areas by sex, age, race/ethnicity, household income, education, census region, and cigarette smoking status and e-cigarette awareness and ever use. RESULTS: Overall, about 40% of adults were uncertain whether e-cigarettes should be allowed in smoke-free areas, 37% opposed, while 23% favored their use in smoke-free public places. Multinomial logistic regression analyses showed that adults who were aware, ever used e-cigarettes, and current cigarette smokers were more likely to express an "in favor" opinion than adults who expressed an uncertain opinion (don't know). CONCLUSION: Over 75% of U.S. adults reported uncertainty or disapproval of the use of e-cigarettes in smoke-free areas. Current cigarette smokers, adults aware or have ever used e-cigarettes were more supportive to exempting e-cigarettes from smoking restrictions. With impending regulation and the changing e-cigarette landscape, continued monitoring and research on public opinions about e-cigarette use in smoke-free places are needed.
Descriptors
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Book Title
Database
Publisher
. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco
Data Source
Authors
Majeed,B.A., Dube,S.R., Sterling,K., Whitney,C., Eriksen,M.P.
Original/Translated Title
URL
Date of Electronic
20141030
PMCID
PMC4838050
Editors
|
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| Genotoxicity of waterpipe smoke in buccal cells and peripheral blood leukocytes as determined by comet assay | 2014 | Biological Sciences Department, Faculty of Science, King Abdulaziz University , Jeddah , Saudi Arabia and. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Inhalation toxicology
Periodical, Abbrev.
Inhal.Toxicol.
Pub Date Free Form
Dec
Volume
26
Issue
14
Start Page
891
Other Pages
896
Notes
LR: 20151119; JID: 8910739; 0 (5-hydroxymethyl-2-furancarboxaldehyde); 0 (Benzaldehydes); 0 (Furans); 0 (Pyrones); 0 (Smoke); 6M3C89ZY6R (Nicotine); YC9ST449YJ (ethyl vanillin); OTO: NOTNLM; 2014/10/30 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1091-7691; 0895-8378
Accession Number
PMID: 25357232
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.3109/08958378.2014.970787 [doi]
Output Language
Unknown(0)
PMID
25357232
Abstract
CONTEXT: Waterpipe smoke causes DNA damage in peripheral blood leukocytes and in buccal cells of smokers. OBJECTIVE: To determine the exposure effect of waterpipe smoke on buccal cells and peripheral blood leukocytes in regard to DNA damage using comet assay. MATERIALS AND METHODS: The waterpipe smoke condensates were analyzed by gas chromatography-mass spectrometry (GC-MS). The study was performed on 20 waterpipe smokers. To perform comet assay on bucaal cells of smokers, 10 microl of cell suspension was mixed with 85 microl of pre-warmed 1% low melting agarose, applied to comet slide and electrophoresed. To analyze the effect of smoke condensate in vitro, 1 ml of peripheral blood was mixed with 10 microl of smoke condensate and subjected for comet assay. RESULTS: The GC-MS analysis revealed the presence of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4on, nicotine, hydroxymethyl furancarboxaldehyde and 3-ethoxy-4-hydroxybenzaldehyde in the smoke condensates. Waterpipe smoking caused DNA damage in vivo in buccal cells of smokers. The tail moment and tail length in buccal cells of smokers were 186 +/- 26 and 456 +/- 71, respectively, which are higher than control. The jurak and moassel smoke condensates were found to cause DNA damage in peripheral blood leukocytes. The moassel smoke condensate was more damaging. DISCUSSION: There is wide misconception that waterpipe smoking is not as harmful as cigarette smoking. This study demonstrated that waterpipe smoke induced DNA damage in exposed cells. CONCLUSION: Waterpipe smokes cause DNA damage in buccal cells. The smoke condensate of both jurak and moassel caused comet formation suggesting DNA damage in peripheral blood leukocytes.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Al-Amrah,H.J., Aboznada,O.A., Alam,M.Z., ElAssouli,M.Z., Mujallid,M.I., ElAssouli,S.M.
Original/Translated Title
URL
Date of Electronic
20141030
PMCID
Editors
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|||
| Update: Ebola virus disease outbreak--West Africa, October 2014 | 2014 | Read more... | |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
MMWR.Morbidity and mortality weekly report
Periodical, Abbrev.
MMWR Morb.Mortal.Wkly.Rep.
Pub Date Free Form
31-Oct
Volume
63
Issue
43
Start Page
978
Other Pages
981
Notes
JID: 7802429; ppublish
Place of Publication
United States
ISSN/ISBN
1545-861X; 0149-2195
Accession Number
PMID: 25356606
Language
eng
SubFile
Journal Article; IM
DOI
mm6343a3 [pii]
Output Language
Unknown(0)
PMID
25356606
Abstract
CDC is assisting ministries of health and working with other organizations to control and end the ongoing outbreak of Ebola virus disease (Ebola) in West Africa. The updated data in this report were compiled from situation reports from the Guinea Interministerial Committee for Response Against the Ebola Virus and the World Health Organization, the Liberia Ministry of Health and Social Welfare, and the Sierra Leone Ministry of Health and Sanitation. Total case counts include all suspected, probable, and confirmed cases as defined by each country. These data reflect reported cases, which make up an unknown proportion of all actual cases and reporting delays that vary from country to country.
Descriptors
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Publisher
Data Source
Authors
Incident Management System Ebola Epidemiology Team, CDC, Guinea Interministerial Committee for Response Against the Ebola Virus, CDC Guinea Response Team, Liberia Ministry of Health and Social Welfare, CDC Liberia Response Team, Sierra Leone Ministry of Health and Sanitation, CDC Sierra Leone Response Team, Viral Special Pathogens Branch, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Centers for Disease Control and Prevention (CDC)
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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|||
| Smoking water pipe is injurious to lungs | 2014 | Afdeling for Social Medicin, Institut for Folkesundhedsvidenskab, Oster Farimagsgade 5, 1014 Kobenhavn K. peter.lange@sund.ku.dk. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Ugeskrift for laeger
Periodical, Abbrev.
Ugeskr.Laeger
Pub Date Free Form
27-Oct
Volume
176
Issue
44
Start Page
V05130301
Other Pages
Notes
LR: 20141030; JID: 0141730; ppublish
Place of Publication
ISSN/ISBN
1603-6824; 0041-5782
Accession Number
PMID: 25353998
Language
DAN
SubFile
JOURNAL ARTICLE
DOI
V05130301 [pii]
Output Language
Unknown(0)
PMID
25353998
Abstract
This review describes the pulmonary consequences of water pipe smoking. Smoking water pipe affects the lung function negatively, is significantly associated with chronic obstructive pulmonary disease and increases the risk of lung infections. Case reports suggest that regular smokers of water pipe have a higher risk of developing malignancies, particularly lung cancer than cigarette smokers.
Descriptors
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Data Source
Authors
Sivapalan,P., Ringbaek,T., Lange,P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Ebola viral hemorrhagic disease outbreak in West Africa- lessons from Uganda | 2014 | Associate Professor, School of Public Health- Makerere University &, Commissioner Health Services, Ministry of Health, Box 7272, Kampala, Uganda.; Senior Epidemiologist, Epidemiology and Surveillance Division, Ministry of Health, Box 7272, Kampala, Uganda | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
African health sciences
Periodical, Abbrev.
Afr.Health.Sci.
Pub Date Free Form
Sep
Volume
14
Issue
3
Start Page
495
Other Pages
501
Notes
LR: 20151029; JID: 101149451; CIN: Afr Health Sci. 2014 Dec;14(4):1085. PMID: 25834522; OID: NLM: PMC4209631; OTO: NOTNLM; ppublish
Place of Publication
Uganda
ISSN/ISBN
1729-0503; 1680-6905
Accession Number
PMID: 25352864
Language
eng
SubFile
Journal Article; IM
DOI
10.4314/ahs.v14i3.1 [doi]
Output Language
Unknown(0)
PMID
25352864
Abstract
BACKGROUND: There has been a rapid spread of Ebola Viral Hemorrhagic disease in Guinea, Liberia and Sierra Leone since March 2014. Since this is the first time of a major Ebola outbreak in West Africa; it is possible there is lack of understanding of the epidemic in the communities, lack of experience among the health workers to manage the cases and limited capacities for rapid response. The main objective of this article is to share Uganda's experience in controlling similar Ebola outbreaks and to suggest some lessons that could inform the control of the Ebola outbreak in West Africa. METHODS: The article is based on published papers, reports of previous Ebola outbreaks, response plans and experiences of individuals who have participated in the control of Ebola epidemics in Uganda. Lessons learnt: The success in the control of Ebola epidemics in Uganda has been due to high political support, effective coordination through national and district task forces. In addition there has been active surveillance, strong community mobilization using village health teams and other community resources persons, an efficient laboratory system that has capacity to provide timely results. These have coupled with effective case management and infection control and the involvement of development partners who commit resources with shared responsibility. CONCLUSION: Several factors have contributed to the successful quick containment of Ebola outbreaks in Uganda. West African countries experiencing Ebola outbreaks could draw some lessons from the Uganda experience and adapt them to contain the Ebola epidemic.
Descriptors
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Database
Publisher
Data Source
Authors
Mbonye,A.K., Wamala,J.F., Nanyunja,M., Opio,A., Makumbi,I., Aceng,J.R.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4209631
Editors
|
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| Secondhand smoke emission levels in waterpipe cafes in Doha, Qatar | 2015 | Tobacco Control Unit, Medicine Department, Hamad Medical Corporation, Doha, Qatar.; Tobacco Control Unit, Medicine Department, Hamad Medical Corporation, Doha, Qatar.; Department of Social & Behavioral Sciences, Center for Global Tobacco Control, Harvard | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tobacco control
Periodical, Abbrev.
Tob.Control
Pub Date Free Form
Oct
Volume
24
Issue
e3
Start Page
e227
Other Pages
31
Notes
CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; JID: 9209612; 0 (Air Pollutants); 0 (Particulate Matter); 0 (Tobacc
Place of Publication
England
ISSN/ISBN
1468-3318; 0964-4563
Accession Number
PMID: 25352562
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1136/tobaccocontrol-2014-051717 [doi]
Output Language
Unknown(0)
PMID
25352562
Abstract
BACKGROUND: Exposure to the emissions of a tobacco waterpipe is associated with increased health risks among its users as well as those exposed to its secondhand smoke. Waterpipe use is an emerging concern to the tobacco control community, particularly among countries of the Eastern Mediterranean Region. In 2002, Qatar adopted legislation that prohibited cigarette smoking inside public venues, but exempted tobacco waterpipe smoking. To inform the development and enforcement of effective policy, the impact of cigarette and waterpipe use on indoor air quality was monitored in waterpipe cafes in Doha, Qatar. METHODS: Particulate matter (PM2.5) levels were measured inside and outside of a sample of 40 waterpipe cafes and 16 smoke-free venues in Doha, Qatar between July and October 2012. In addition, the number of waterpipes being smoked and the number of cigarette smokers were counted within each venue. Non-paired and paired sample t tests were used to assess differences in mean PM2.5 measurements between venue type (waterpipe vs smoke-free) and environment (indoor vs outdoor). RESULTS: The mean PM2.5 level inside waterpipe venues (476 mug/m(3)) was significantly higher than the mean PM2.5 level inside smoke-free venues (17 mug/m(3); p
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Al Mulla,A., Fanous,N., Seidenberg,A.B., Rees,V.W.
Original/Translated Title
URL
Date of Electronic
20141028
PMCID
Editors
|
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| Prevalence and Risk Factors for Barrett's Esophagus in Patients with GERD in Northern India; Do Methylene Blue-directed Biopsies Improve Detection of Barrett's Esophagus Compared the Conventional Method? | 2014 | Department of Gastroenterology, India.; Resident, Department of Internal Medicine, India.; Professor, Department of Gastroenterology, India.; Student, Department of Internal Medicine, India. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Middle East journal of digestive diseases
Periodical, Abbrev.
Middle East.J.Dig.Dis.
Pub Date Free Form
Oct
Volume
6
Issue
4
Start Page
228
Other Pages
236
Notes
LR: 20141030; JID: 101535395; OID: NLM: PMC4208931; OTO: NOTNLM; 2014/05/21 [received]; 2014/09/09 [accepted]; ppublish
Place of Publication
Iran
ISSN/ISBN
2008-5230; 2008-5230
Accession Number
PMID: 25349686
Language
eng
SubFile
Journal Article
DOI
Output Language
Unknown(0)
PMID
25349686
Abstract
BACKGROUND The reported rates of Barrett's esophagus (BE) ranged from 2.6% to 23% in Indian patients with gastro-esophageal reflux disease (GERD) symptoms. The role of methylene blue chromoendoscopy during endoscopy, either for the diagnosis of Barrett's esophagus or for the detection of dysplasia and early cancer, remains controversial. AIM: Our study was designed to find out the endoscopic as well as histological prevalence of BE in India in a specified patient population affected by GERD, and whether methylene blue chromoendoscopy improves detection of specialized intestinal metaplasia in endoscopically suspected Barrett's esophagus in GERD patients. METHODS Three hundred and seventy eight patients with characteristic symptoms of GERD from Northern India were subjected to upper endoscopy. On endoscopic suspicion of columnar lined epithelium (CLE) either 4-quadrant conventional biopsies at 2 cm interval or Methylene Blue (MB) directed biopsies were obtained randomly. The two groups were compared for the detection of Specialized Intestinal Metaplasia (SIM), which was diagnosed if the intestinal goblet cells were present. RESULTS Out of 378 patients with GERD, 56 (14.81%) were suspected of CLE on endoscopy. After taking biopsy samples from the 56 patients, only 9 (2.38%) had specialized intestinal metaplasia on histopathological examination. Five (15.15%) patients in the conventional group and four (17.39%) patients in the chromoendoscopy group (p=0.55) were diagnosed as having BE. On univariate analysis the predictors of SIM were symptoms of reflux and length of CLE. CONCLUSION The prevalence of biopsy proven BE and CLE in Northern India was 2.38% and 14.81%, respectively in patients with symptoms of GERD. The results of MB directed biopsies were similar to conventional biopsies in detecting SIM.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Wani,I.R., Showkat,H.I., Bhargav,D.K., Samer,M.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4208931
Editors
|
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