WTS database

Title	Pub Year	Author Sort ascending	SearchLink
Testing a process-based model of tree seedling growth by manipulating [CO2] and nutrient uptake	2000	Levy, P.E., Institute of Terrestrial Ecology, Penicuik, Midlothian EH26 0QB, United Kingdom	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tree physiology Periodical, Abbrev. Tree Physiol. Pub Date Free Form 2000/ Volume 20 Issue 15 Start Page 993 Other Pages 1005 Notes Place of Publication ISSN/ISBN 0829-318X Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract A model was developed that simulated photosynthesis, growth and allocation in tree seedlings. The model was parameterized with data from experiments on seedlings of sycamore (Acer pseudoplatanus L.), Sitka spruce (Picea sitchensis (Bong) Carr.) and young birch trees (Betula pendula Roth.). In these experiments, CO2 concentration ([CO2]) and nutrient addition rate were varied. Parameters quantifying nutrient uptake, translocation and starch synthesis were fitted, based on data from control treatments. Elevated [CO2] and low-nutrient treatments were then used to test the predicted response of growth and allocation against observations. The model accurately predicted total seedling growth in the elevated [CO2] treatments. A response of growth to elevated [CO2] was seen in the birch and sycamore experiments, but not in the Sitka spruce, because of photosynthetic down-regulation. Predictions of allocation were reasonably accurate in the birch and Sitka spruce experiments, but were notably poorer in the sycamore experiments, possibly because of differences in sink strength between root and shoot. In the birch and sycamore experiments, little change in allocation with elevated [CO2] was observed or predicted. This was ascribed to the relative values of K(Tc) and K(Tn), the translocation coefficients that determine the sensitivity of allocation to carbon and nitrogen uptake rates, respectively. Growth and allocation in the low-nutrient treatments were poorly predicted by the model. In Sitka spruce, it was suspected that the photosynthetic parameters measured in August 1994 had been higher earlier in the season, before nutrients became depleted. In sycamore, the discrepancies were thought to relate to differences in sink strength between root and shoot that could not be described by the model. Descriptors carbon dioxide, article, biological model, down regulation, growth, development and aging, photosynthesis, physiology, plant leaf, plant root, plant stem, tree Links Book Title Database MEDLINE Publisher Data Source Embase Authors Levy,P. E., Lucas,M. E., McKay,H. M., Escobar-Gutierrez,A. J., Rey,A. Original/Translated Title URL Date of Electronic PMCID Editors
Pathologic, morphologic and anthropologic characteristics of Avarian teeth and jaws from graves in Becej	1991	LetiÄ‡, V.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Srpski arhiv za celokupno lekarstvo Periodical, Abbrev. Srp.Arh.Celok.Lek. Pub Date Free Form / Volume 119 Issue 6-May Start Page 125 Other Pages 129 Notes Place of Publication ISSN/ISBN 0370-8179 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract During the reconstruction of the water pipe lines, in Pionirska street, at Bechej in 1989, a part of a large graveyard was uncovered. Human remains were found in graves, below the level of the underground water, so that the most of the human skeletons were either completely destroyed, or partly preserved. A few graves were damaged during excavations in previous ears and some of the graves were robbed also at an earlier period. Paleopathological and anthropological investigation carried out at the Department of Anatomy, Faculty of Medicine in Novi Sad, revealed that these remains belong to an Avarian population which had similar epigenetic and anthropometric characteristics as the Avarian population found at the well known site at Kiskoros Vagohid, in Hungary, precisely the skeleton from the grave No. XXXV. Study of the teeth and jaws complete these results. At six mandibles, which belong to the mature skeletons, was found narrowness in the frontal region of the mandibular alveolar arch was recorded. Degree of narrowness of the frontal mandibular dental arch, deficient in space at mandibles was different, and varied from 2 mm to 8.5 mm, or 3 to 24.38%, which is necessary to set the teeth in the correct line in a mandible. Descriptors article, dentition, histology, history, human, mandible, physical anthropology, Yugoslavia Links Book Title Patoloske, morfoloske i antropoloske karakteristike zuba i vilica Avara iz nekropole u Beceju. Database MEDLINE Publisher Data Source Embase Authors LetiÄ‡,V., DjuriÄ‡-SrejiÄ‡,M. Original/Translated Title URL Date of Electronic PMCID Editors
Environmental lead exposure in a population of children in northern France: Factors affecting lead burden	2000	Leroyer, A., Ctr. de Rech/Sante Travail Ergonomie, 59037 Lille Cedex, France	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Industrial Medicine Periodical, Abbrev. Am.J.Ind.Med. Pub Date Free Form 2000/ Volume 38 Issue 3 Start Page 281 Other Pages 289 Notes Place of Publication ISSN/ISBN 0271-3586 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Background: This study is part of the assessment of a site in northern France polluted by lead from industrial emissions. Our objectives were to look for the factors that influence lead burden in children aged 8-11 years. Methods: A cross-sectional population-based study took place in 1996-97 and included 400 children (200 of whom lived on the metal-polluted site). Results: The geometric mean of the blood-lead levels of children living on the polluted site was 39.5 Î¼g/l (95% CI = 36.3-43.1); that of the non-exposed children was 30.6 Î¼g/l (95% CI=27.8-33.6) (P<0.0001). Analysis of the variations in the mean blood-lead levels showed associations with: Distance from the smelting plants (mean blood-lead level fell by a factor of 1/1.3 (95% CI = 1/1.2-1/1.4) for each km from the smelter over the range of 1-3 km and was constant thereafter) and consumption of tap water (when the water pipes were made of lead, the mean blood-lead level of children who drank tap water was twice as high (95% CI=1.2-3.4) as that of children who did not). Conclusions: The children's blood-lead levels were essentially linked to two factors: Proximity to the smelters and drinking tap rather than bottled water. (C) 2000 Wiley-Liss, Inc. Descriptors lead, tap water, body burden, child, conference paper, controlled study, environmental exposure, female, fluid intake, France, human, lead blood level, lead poisoning, major clinical study, male, population risk, residential home, risk factor, smelter, soil pollution, water contamination Links Book Title Database Embase; MEDLINE Publisher Data Source Embase Authors Leroyer,A., Nisse,C., Hemon,D., Gruchociak,A., Salomez,J. -L, Haguenoer,J. -M Original/Translated Title URL Date of Electronic PMCID Editors
Development of an innovative and "green" stir bar sorptive extraction-thermal desorption-gas chromatography-tandem mass spectrometry method for quantification of polycyclic aromatic hydrocarbons in marine biota	2014	LEMAR - UMR 6539 - Technopole de Brest-Iroise, 29280 Plouzane, France. Electronic address: camlacroix@hotmail.fr.; CEDRE - 715, Rue Alain Colas/CS 41836, 29218 Brest Cedex 2, France.; CEDRE - 715, Rue Alain Colas/CS 41836, 29218 Brest Cedex 2, France.; LE	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.A Periodical, Abbrev. J.Chromatogr.A Pub Date Free Form 4-Jul Volume 1349 Issue Start Page 1 Other Pages 10 Notes CI: Copyright (c) 2014; JID: 9318488; 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Water Pollutants, Chemical); OTO: NOTNLM; 2014/02/13 [received]; 2014/04/28 [revised]; 2014/04/29 [accepted]; 2014/05/04 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-3778; 0021-9673 Accession Number PMID: 24857036 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.chroma.2014.04.094 [doi] Output Language Unknown(0) PMID 24857036 Abstract There is a growing awareness of the need to reduce the negative impact of chemical analyses on the environment and to develop new eco-friendly and sustainable analytical methods without compromising performance. In this study, we developed a "green" analytical method enabling the accurate and simultaneous routine analysis of 21 polycyclic aromatic hydrocarbons (PAHs) in reduced quantities (100mg and 1g wet weight (WW)) of marine biota samples (fish muscle, mussel and oyster tissues) using alkaline digestion combined with stir bar sorptive extraction-thermal desorption-gas chromatography-tandem mass spectrometry (SBSE-GC-MS/MS). The innovative method provides good selectivity and specificity for most compounds. In 1gWW samples, limits of quantification (LOQs) ranged from 1 to 10mug/kgWW in fish muscle and from 0.5 to 10mug/kgWW in mussel tissue. The method enables most analytes to be quantified below the restrictive limits established by the European Commission (2 and 10mug/kgWW in fish muscle and bivalve mollusc, respectively). Higher LOQs were obtained in 100mgWW samples ranging from 1 to 50mug/kgWW. Recovery and linearity were assessed for all analytes. The results were satisfactory for most compounds with recoveries ranging from 94% to 117% in 1gWW mussel samples at spike concentration of 10ng/gWW with standard deviation not exceeding 12%. However, results confirmed that the SBSE efficiency is affected by the complexity of biological matrices, especially for high molecular weight compounds in lipid-rich mussel tissue. Because of the matrix effects, matrix-matched calibrations were carried out. Validation was performed using the standard reference material 1974c with recovery ranging from 71% to 119% except for naphthalene, anthracene and benzo(e)pyrene that were therefore not validated. Overall, the developed method meets analytical validation criteria for most compounds. Thanks to the combination of alkaline digestion and SBSE, which greatly simplifies sample treatment and limits solvent use to ethanol, the developed method followed most green analytical chemistry principles. Descriptors Links Book Title Database Publisher Elsevier B.V Data Source Authors Lacroix,C., Le Cuff,N., Receveur,J., Moraga,D., Auffret,M., Guyomarch,J. Original/Translated Title URL Date of Electronic 20140504 PMCID Editors
Effects of acid mist on needles from mature sitka spruce grafts. Part II. Influence of developmental stage, age and needle morphology on visible damage	1995	Leith, I.D., Institute of Terrestrial Ecology, Edinburgh Research Station, Bush Estate, Penicuik, Midlothian EH26 0QB, United Kingdom	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Environmental Pollution Periodical, Abbrev. Environ.Pollut. Pub Date Free Form 1995/ Volume 90 Issue 3 Start Page 363 Other Pages 370 Notes Place of Publication ISSN/ISBN 0269-7491 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Mature grafts of five Sitka spruce (Picea sitchensis (Bong.) Carr.) clones were exposed to simulated acid mist comprising an equimolar mixture of H2SO4 and NH4NO3 (16 and 0.01 mol m-3) at pH 2.5 and 5.0. Mist was applied to potted plants growing in open-top chambers on consecutive days, four times a week, at a precipitation equivalent of 1 mm per day. The total exposure to polluted mist was equivalent to three times that measured at an upland forest in SE Scotland. The aim of the experiment was to characterize the response of juvenile foliage produced by physiologically mature grafts (on seedling root stock) and compare it with the behaviour of juvenile foliage on seedlings. Development of visible foliar damage was followed through the growing season. Measurements of needle length, diameter, weight, surface area, surface wax weight and wettability were made on current year needles to determine whether particular foliar characteristics increased susceptibility to injury. Significant amounts (> 10%) of visible needle damage was observed on only one of the five clones. Damage was most severe on the clone with the most horizontal branch and needle habit, but over the five clones there was no relationship between angle of branch display and damage. Likewise no combination of needle characteristics (length, width, area, amount of wax) was indicative of potential susceptibility. A comparison with previous acid misting experiments using seedlings suggests that juvenile foliage on physiologically mature trees is equally susceptible to visible injury as juvenile seedling foliage. Date of budburst differed among clones, and in this experiment exerted the over-riding influence on development of injury symptoms. Foliage exposed to a combination of strong acidity and high sulphate concentrations over the few weeks immediately following budburst suffered most visible injury. The absence of significant amounts of visible damage in UK forests probably reflects the general low susceptibility to visible injury of Sitka spruce exposed to acid mist. Descriptors ammonium nitrate, sulfate, sulfuric acid, acid rain, article, comparative study, controlled study, forest, morphology, nonhuman, pH, plant growth, plant leaf, precipitation, simulation, tree, United Kingdom Links Book Title Database Embase Publisher Data Source Embase Authors Leith,I. D., Sheppard,L. J., Cape,J. N. Original/Translated Title URL Date of Electronic PMCID Editors
The microbial diversity of water kefir	2011	Lehrstuhl fur Technische Mikrobiologie, Weihenstephaner Steig 16, 85350 Freising, Germany.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full International journal of food microbiology Periodical, Abbrev. Int.J.Food Microbiol. Pub Date Free Form 15-Dec Volume 151 Issue 3 Start Page 284 Other Pages 288 Notes CI: Copyright (c) 2011; JID: 8412849; 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S); 2011/04/27 [received]; 2011/09/09 [revised]; 2011/09/18 [accepted]; 2011/09/24 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1879-3460; 0168-1605 Accession Number PMID: 22000549 Language eng SubFile Journal Article; IM DOI 10.1016/j.ijfoodmicro.2011.09.016 [doi] Output Language Unknown(0) PMID 22000549 Abstract The microbial diversity of water kefir, made from a mixture of water, dried figs, a slice of lemon and sucrose was studied. The microbial consortia residing in the granules of three water kefirs of different origins were analyzed. A collection of 453 bacterial isolates was obtained on different selective/differential media. Bacterial isolates were grouped with randomly amplified polymorphic DNA (RAPD)-PCR analyses. One representative of each RAPD genotype was identified by comparative 16S rDNA gene sequencing. The predominant genus in water kefirs I and II was Lactobacillus, which accounted for 82.1% in water kefir I and 72.1% in water kefir II of the bacterial isolates. The most abundant species in water kefirs I and II were Lactobacillus hordei and Lb. nagelii followed by considerably lower numbers of Lb. casei. Other lactic acid bacteria (LAB) were identified as Leuconostoc mesenteroides and Lc. citreum in all three water kefirs. The most abundant species in water kefir III was Lc. mesenteroides (28%) and Lc. citreum (24.3%). A total of 57 LAB belonging to the species of Lb. casei, Lb. hordei, Lb. nagelii, Lb. hilgardii and Lc. mesenteroides were able to produce exopolysacchrides from sucrose. Non LABs were identified as Acetobacter fabarum and Ac. orientalis. The Acetobacter species were more prevalent in consortium III. Cluster analyses of RAPD-PCR patterns revealed an interspecies diversity among the Lactobacillus and Acetobacter strains. Aditionally, Saccharomyces cerevisiae, Lachancea fermentati, Hanseniaospora valbyensis and Zygotorulaspora florentina were isolated and identified by comparison of partial 26S rDNA sequences and FTIR spectroscopy. Descriptors Links Book Title Database Publisher . Published by Elsevier B.V Data Source Authors Gulitz,A., Stadie,J., Wenning,M., Ehrmann,M.A., Vogel,R.F. Original/Translated Title URL Date of Electronic 20110924 PMCID Editors
Phenotypic and genotypic analyses of lactic acid bacteria in local fermented food, breast milk and faeces of mothers and their babies	2011	Lehrstuhl fur Technische Mikrobiologie, Technische Universitat Munchen, Weihenstephaner Steig 16, 85350 Freising, Germany.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Systematic and applied microbiology Periodical, Abbrev. Syst.Appl.Microbiol. Pub Date Free Form Apr Volume 34 Issue 2 Start Page 148 Other Pages 155 Notes CI: Copyright (c) 2011; JID: 8306133; 2010/11/05 [received]; 2010/12/20 [revised]; 2010/12/21 [accepted]; ppublish Place of Publication Germany ISSN/ISBN 1618-0984; 0723-2020 Accession Number PMID: 21300508 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.syapm.2010.12.001 [doi] Output Language Unknown(0) PMID 21300508 Abstract Lactic acid bacteria (LAB) are generally accepted as beneficial to the host and their presence is directly influenced by ingestion of fermented food or probiotics. While the intestinal lactic microbiota is well-described knowledge on its routes of inoculation and competitiveness towards selective pressure shaping the intestinal microbiota is limited. In this study, LAB were isolated from faecal samples of breast feeding mothers living in Syria, from faeces of their infants, from breast milk as well as from fermented food, typically consumed in Syria. A total of 700 isolates were characterized by genetic fingerprinting with random amplified polymorphic DNA (RAPD) and identified by comparative 16S rDNA sequencing and Matrix Assisted Laser Desorption Ionization-Time-Of-Flight Mass Spectrometry (MALDI-TOF-MS) analyses. Thirty six different species of Lactobacillus, Enterococcus, Streptococcus, Weissella and Pediococcus were identified. RAPD and MALDI-TOF-MS patterns allowed comparison of the lactic microbiota on species and strain level. Whereas some species were unique for one source, Lactobacillus plantarum, Lactobacillus fermentum, Pediococcus pentosaceus and Lactobacillus brevis were found in all sources. Interestingly, identical RAPD genotypes of L. plantarum, L. fermentum, L. brevis, Enterococcus faecium, Enterococcus faecalis and P. pentosaceus were found in the faeces of mothers, her milk and in faeces of her babies. Diversity of RAPD types found in food versus human samples suggests the importance of host factors in colonization and individual host specificity, and support the hypothesis that there is a vertical transfer of intestinal LAB from the mother's gut to her milk and through the milk to the infant's gut. Descriptors Links Book Title Database Publisher Elsevier GmbH Data Source Authors Albesharat,R., Ehrmann,M.A., Korakli,M., Yazaji,S., Vogel,R.F. Original/Translated Title URL Date of Electronic PMCID Editors
Diving pattern of fishermen in the Pescadores.	1994	Lee, H.C., Department of Hyperbaric Medicine, Naval General Hospital, Kaohsiung, ROC.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc Periodical, Abbrev. Undersea Hyperb.Med. Pub Date Free Form / Volume 21 Issue 2 Start Page 145 Other Pages 158 Notes Place of Publication ISSN/ISBN 1066-2936 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Professional diving fishermen in the Pescadores Archipelago (119.30 degrees W, 23.30 degrees N) dive with a simple hookah system. Although they use modern equipment, such as wet suit, face mask, mouth piece with demand valve, spear gun, weight belt, and fins, their lack of knowledge of diving medicine is apparent. On the average, 180 cases of decompression sickness (DCS) per year were reported to occur in the Pescadores. We conducted studies in 1990 and 1992 on three islands of the Archipelago. At the time of our study, an estimated 140 diving fishermen resided on these three islands. Of the 62 fishermen interviewed, 14 volunteered for the recording of dive profiles using a diver-carried data logger. In the summer of 1990, a group of eight fishermen dived, on the average, to a depth of 17.8 +/- 5.3 m (mean +/- SD; range, 8-27 m) for 26.9 +/- 19.7 min (5-66 min). Although the diving depth was similar to that of the average recollections of 43 divers, 20.1 +/- 4.4 m (15-30 m), the actual diving time was far shorter than that of their recollections, 426 +/- 138 min (240-630 min). The post-typhoon sea floor conditions may have shortened their diving time. In the summer of 1992, a group of six fishermen dived to 20.5 +/- 3.8 m (15-26 m) for 56.4 +/- 21.2 min (18-84 min). Again, the diving depth matched that of their recollection well, 22.2 +/- 2.5 m (20-26 m), but their bottom time was far shorter than they believed, 270 +/- 108 min (120-480 min). They used no decompression procedures, regardless of the bottom time and diving depth. In the 1990 group, 5 out of 10 equivalent single dive bottom times (ESDBT) exceeded U.S. Navy no-decompression (No-D) air dive limits; whereas in the 1992 group, 7 out of 9 ESDBTs exceeded No-D limits. Eight of the 38 discrete dives exceeded the No-D limits, even if we underestimate their decompression stress by disregarding their repetitive dive history. However, no symptoms of DCS were observed in either the 1990 or 1992 groups of 14 divers, despite 63% of the ESDBTs and 21% of discrete dives having exceeded the No-D limits. Adaptation to diving work may have allowed them to exceed the established No-D limits. The existing records of incidence of DCS from this region suggest that previously they must have dived longer or deeper or both during times of abundant resources. Descriptors adult, article, diving, heart rate, human, Japan, middle aged, Pacific islands, physiology, statistics, time Links Book Title Database MEDLINE Publisher Data Source Embase Authors Lee,H. C., Niu,K. C., Huang,K. L., Tsai,J. D., Shyu,R. K., Shiraki,K., Hong,S. K., Lin,Y. C. Original/Translated Title URL Date of Electronic PMCID Editors
Efficacy of resident training in smoking cessation: a randomized, controlled trial of a program based on application of behavioral theory and practice with standardized patients	2002	Lausanne University Outpatient Clinic and Institute of Social and Preventive Medicine, Lausanne, Switzerland. Jacques.Cornuz@chuv.hospvd.ch	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of Internal Medicine Periodical, Abbrev. Ann.Intern.Med. Pub Date Free Form 19-Mar Volume 136 Issue 6 Start Page 429 Other Pages 437 Notes LR: 20061115; JID: 0372351; ppublish Place of Publication United States ISSN/ISBN 1539-3704; 0003-4819 Accession Number PMID: 11900495 Language eng SubFile Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; AIM; IM DOI 200203190-00006 [pii] Output Language Unknown(0) PMID 11900495 Abstract BACKGROUND: New educational programs must be developed to improve physicians' skills and effectiveness in counseling patients about smoking cessation. OBJECTIVE: To assess the efficacy of an educational program based on behavioral theory, active learning methods, and practice with standardized patients in helping patients abstain from smoking and changing physicians' counseling practices. DESIGN: Cluster randomized, controlled trial. SETTING: Two general internal medicine clinics in Switzerland. PARTICIPANTS: 35 residents and 251 consecutive smoking patients. INTERVENTION: A training program administered over two half-days, during which physicians learned to provide counseling that matched smokers' motivation to quit and practiced these skills with standardized patients acting as smokers at different stages of change. The control intervention was a didactic session on management of dyslipidemia. MEASUREMENTS: Self-reported abstinence from smoking at 1 year of follow-up, which was validated by exhaled carbon monoxide testing at one clinic; score of overall quality of counseling based on use of 14 counseling strategies; patient willingness to quit; and daily cigarette consumption. RESULTS: At 1 year of follow-up, abstinence from smoking was significantly higher in the intervention group than in the control group (13% vs. 5%; P = 0.005); this corresponded to a cluster-adjusted odds ratio of 2.8 (95% CI, 1.4 to 5.5). Residents who received the study training provided better counseling than did those who received the control training (mean score, 4.0 vs. 2.7; P = 0.002). Smokers' willingness to quit was also higher in the intervention group (94% vs. 80%; P = 0.007). A nonsignificant trend toward lower daily cigarette consumption in the intervention group was observed. CONCLUSION: A training program in smoking cessation administered to physicians that was based on behavioral theory and practice with standardized patients significantly increased the quality of physicians' counseling, smokers' motivation to quit, and rates of abstinence from smoking at 1 year. Descriptors Adolescent, Adult, Aged, Behavior Therapy, Clinical Competence, Counseling/methods, Double-Blind Method, Family Practice/education, Female, Follow-Up Studies, Humans, Hyperlipidemias/prevention & control, Internal Medicine/education, Internship and Residency, Male, Motivation, Smoking Cessation/methods/psychology Links Book Title Database Publisher Data Source Authors Cornuz,J., Humair,J. P., Seematter,L., Stoianov,R., van Melle,G., Stalder,H., Pecoud,A. Original/Translated Title URL Date of Electronic PMCID Editors
Early invasive pulmonary aspergillosis in a leukemia patient linked to aspergillus contaminated marijuana smoking	2001	Lahav, M., Medicine E Sapir Medical Center, Meir Hospital, Tel-Aviv University, Kfar Saba, Israel	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Leukemia and Lymphoma Periodical, Abbrev. Leuk.Lymphoma Pub Date Free Form 2001/ Volume 42 Issue 6 Start Page 1433 Other Pages 1437 Notes Place of Publication ISSN/ISBN 1042-8194 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract 46-year-old patient with acute myeloid leukemia (AML) whose disease manifested as fever, chills and dry cough is reported here. Despite broad antibiotic coverage he remained acutely ill with spiking fever, shaking chills, and hypoxemia. His initial chest radiograph was normal but chest computed tomography (CT) scan disclosed bilateral focal infiltrates. Hypoxemia and severe thrombocytopenia precluded invasive diagnostic procedures. A thorough epidemiological investigation revealed that before becoming acutely ill the patient smoked daily tobacco mixed with marijuana from a "hookah bottle". While waiting for tobacco and "hookah water" cultures, we started antifungal therapy. Resolution of fever and hypoxemia ensued after 72 hours. Tobacco cultures yielded heavy growth of Aspergillus species. We suggest that habitual smoking of Aspergillus-infested tobacco and marijuana caused airway colonization with Aspergillus. Leukemia rendered the patient immunocompromised, and allowed Aspergillus to infest the lung parenchyma with early occurrence of invasive pulmonary aspergillosis. Physicians should be aware of this potentially lethal complication of "hookah" and marijuana smoking in immunocompromised hosts. Descriptors amphotericin B, antibiotic agent, antifungal agent, cytarabine, etoposide, idarubicin, acute disease, acute myeloblastic leukemia, adult, antibiotic therapy, article, Aspergillus, cannabis addiction, case report, chill, computer assisted tomography, coughing, diagnostic procedure, disease severity, drug megadose, fever, fungal contamination, fungus culture, human, hypoxemia, immune deficiency, lung aspergillosis, lung infiltrate, lung parenchyma, male, priority journal, respiratory tract infection, smoking, thorax radiography, thrombocytopenia, tobacco, treatment failure Links Book Title Database Embase; MEDLINE Publisher Data Source Embase Authors Szyper-Kravitz,M., Lang,R., Manor,Y., Lahav,M. Original/Translated Title URL Date of Electronic PMCID Editors

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