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Cytotoxic effects of BADGE (bisphenol A diglycidyl ether) and BFDGE (bisphenol F diglycidyl ether) on Caco-2 cells in vitro 2006 Microbiology and Biotoxins Area, ANFACO-CECOPESCA, Campus Univ de Vigo, Vigo, Pontevedra, Spain.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Archives of Toxicology
Periodical, Abbrev.
Arch.Toxicol.
Pub Date Free Form
Nov
Volume
80
Issue
11
Start Page
748
Other Pages
755
Notes
LR: 20131121; JID: 0417615; 0 (Actins); 0 (Benzhydryl Compounds); 0 (Epoxy Compounds); 0 (bisphenol F diglycidyl ether); 36015-30-2 (Propidium); EC 1.1.1.27 (L-Lactate Dehydrogenase); F3XRM1NX4H (2,2-bis(4-glycidyloxyphenyl)propane); 2006/03/21 [received]
Place of Publication
Germany
ISSN/ISBN
0340-5761; 0340-5761
Accession Number
PMID: 16783546
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1007/s00204-006-0121-1 [doi]
Output Language
Unknown(0)
PMID
16783546
Abstract
Bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) are used as starting substances for the manufacturing of epoxy resins used in internal can coatings. They are obtained by a condensation reaction between epichlorohydrin with bisphenol A and bisphenol F, respectively. These potential endocrine disrupting chemicals are able to enter the food chain and to reach the intestinal epithelium, causing structural and functional damages. The human colorectal adenocarcinoma cell line Caco-2 is a widely used in vitro model of the intestinal cells. The aim of this study was to characterize BADGE and BFDGE toxicity in Caco-2 cells, in particular, at the cellular and molecular level. Using several approaches, we characterized BADGE- and BFDGE-induced cell toxicity in Caco-2 cells. The treatment was done using different concentrations up to cytotoxic doses and different times of exposure to the agents. We evaluated the effect of these compounds on cell morphology, cell detachment, cell proliferation, F-actin disruption and plasma membrane integrity. Both compounds are able to induce morphological changes, cell detachment from the substratum and to inhibit cell proliferation, being these effects time and dose-dependent. Moreover, BADGE and BFDGE induce F-actin depolymerization, this effect is very potent at 24 h of incubation with the agents and a complete F-actin disruption can be observed at 200 microM BADGE or BFDGE. In addition, cell integrity is not damaged, since neither propidium iodide uptake nor LDH release takes place in Caco-2 cells exposed to high doses of these agents for 24 h.
Descriptors
Actins/metabolism, Benzhydryl Compounds, Caco-2 Cells, Cell Adhesion/drug effects, Cell Membrane/drug effects/metabolism, Cell Proliferation/drug effects, Cytoskeleton/drug effects, Epoxy Compounds/toxicity, Humans, L-Lactate Dehydrogenase/metabolism, Propidium/metabolism
Links
Book Title
Database
Publisher
Data Source
Authors
Ramilo,G., Valverde,I., Lago,J., Vieites,J. M., Cabado,A. G.
Original/Translated Title
URL
Date of Electronic
20060617
PMCID
Editors
Czech adolescent smokers: unhappy to smoke but unable to quit 2013 Centre for Tobacco-Dependent Patients, 3rd Medical Department, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Periodical, Abbrev.
Int.J.Tuberc.Lung Dis.
Pub Date Free Form
Jun
Volume
17
Issue
6
Start Page
842
Other Pages
846
Notes
LR: 20151119; JID: 9706389; ppublish
Place of Publication
France
ISSN/ISBN
1815-7920; 1027-3719
Accession Number
PMID: 23676173
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.5588/ijtld.12.0753 [doi]
Output Language
Unknown(0)
PMID
23676173
Abstract
OBJECTIVE: To assess the prevalence of tobacco dependence among adolescents in the Czech Republic in 2010, their willingness to quit and knowledge about quitting options. METHODS: Primary, intermediate and secondary school students completed an anonymous questionnaire on tobacco use during a smoking prevention class, with a response rate of 100%. RESULTS: Of 1420 anonymous questionnaires analysed, 66.8% (n = 949) of respondents had ever tried smoking. More were from smoking (50.4%) than non-smoking (49.6%) families; there were no differences in sex. Most student smokers had experimented with cigarettes (94.6%), cigars (8%), marihuana cigarettes (4.6%) and water pipes (1.9%). At the time of the survey, 52.9% (520/949) of those who had ever tried smoking were current smokers, 30.3% smoked daily, 18.3% weekly and 4.2% less frequently. Only 20.5% of smokers had not considered quitting, and 66.9% had tried unsuccessfully to quit. Withdrawal symptoms were experienced by 24.5% (123/502) of the current smokers, indicating a high level of nicotine dependence in this age group. The majority (346/467, 74.1%) of the current smokers said they would stop smoking immediately on their own. Only a few would seek help at a pharmacy (4.9%), 3.4% would ask their doctor and 1.7% their parents. CONCLUSIONS: Tobacco dependence is prevalent among Czech adolescents. The majority of smokers wanted to stop, but knowledge about smoking cessation and quitting assistance offered to smokers was low.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Kralikova,E., Kmetova,A., Zvolska,K., Blaha,M., Bortlicek,Z.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Czy fajka wodna stanowi bezpieczna alternatywe dla palenia papierosów? 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Przegl Lek
Periodical, Abbrev.
Przegl.Lek.
Pub Date Free Form
Volume
69
Issue
10
Start Page
1090
Other Pages
4
Notes
ID: 23421097
Place of Publication
ISSN/ISBN
Accession Number
Language
pl
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Waterpipe smoking is a traditional habit in Arab World, Turkey, Middle East and Central Asia. Recently it became popular in many countries, mostly among young people. A background of growing prevalence is discussed separately for countries with an old tradition of water pipe smoking and for those where it appeared recently. Contrary to smokers belief numerous studies indicate that waterpipe being responsible for adverse health effects is not a safe alternative for cigarette smoking. Furthermore, waterpipe smoking is conducive to tobacco smoking dependence and may leave a part of the group as cigarette smokers. Hence, tobacco control policies should cover also waterpipe smoking.
Descriptors
Links
http://pesquisa.bvsalud.org/ghl/resource/en/mdl-23421097
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Szyfter,Anna, Giefing,Maciej
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Daily and peak 1 h indoor air pollution and driving factors in a rural Chinese village 2007 Environmental Health Sciences, School of Public Health, 140 Warren Hall #7360, University of California at Berkeley, Berkeley, California 94720-7360, USA. sfischer@berkeley.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environmental science & technology
Periodical, Abbrev.
Environ.Sci.Technol.
Pub Date Free Form
1-May
Volume
41
Issue
9
Start Page
3121
Other Pages
3126
Notes
LR: 20131121; JID: 0213155; 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); 7U1EE4V452 (Carbon Monoxide); ppublish
Place of Publication
United States
ISSN/ISBN
0013-936X; 0013-936X
Accession Number
PMID: 17539514
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
17539514
Abstract
We investigate wintertime indoor air quality and personal exposures to carbon monoxide (CO) in a rural village in Jilin province, where relatively homogeneous climatic and sociocultural factors facilitate investigation of household structural, fuel-related, and behavioral determinants of air pollution as well as relationships between different measures of air quality. Our time-resolved wintertime measurements of carbon monoxide and respirable particles (RSP) enable exploration of peak pollution periods in a village in Jilin Province, China, characterized by household use of both coal and biomass, as well as several "improved" (gas or electric) fuels. Our data indicate a 6-fold increase in peak 1 h PM (1.9 mg/m3) concentrations relative to 24 h mean PM (0.31 mg/m3). Peak 1 h CO concentrations (20.5 ppm) routinely approached and often (27%) exceeded the World Health Organization's 1 h guideline of 26 ppm, although the vast majority (95%) of kitchens were within China's residential indoor air quality guideline for CO on a 24 h basis. Choice of heating fuel and household smoking status were significant predictors of indoor air quality. Whether solid or "improved" (gas or electric) fuel was used for cooking had an even stronger effect, but in the opposite direction from expected, on both peak and daily average measures of air pollution. Peak pollution period concentrations of CO and PM were strongly correlated to daily concentrations of CO and RSP, respectively. Our results suggestthat due to the primary role of heating as a determinant of wintertime indoor air quality in northern Chinese villages, health-oriented interventions limited to provision of improved cooking fuel are insufficient. Our results illustrate that peak pollution periods may routinely exceed exposure regulations and evacuation limits, although this and previous studies document typical 24 h CO concentrations in rural Chinese kitchens to be within guidelines. Within a given village and for a given pollutant, daily pollutant concentrations may be strong predictors of peak pollution period concentrations.
Descriptors
Air Pollution, Indoor/analysis, Carbon Monoxide/analysis, China, Cooking, Environmental Monitoring, Housing, Humans, Particulate Matter/analysis, Rural Population, Tobacco Smoke Pollution
Links
Book Title
Database
Publisher
Data Source
Authors
Fischer,S. L., Koshland,C. P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Daily intake of copper from drinking water among young children in Sweden 1999 Pettersson, R., Department of Pediatrics, Central Hospital, S-541 85 Skovde, Sweden
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environmental health perspectives
Periodical, Abbrev.
Environ.Health Perspect.
Pub Date Free Form
1999/
Volume
107
Issue
6
Start Page
441
Other Pages
446
Notes
Place of Publication
ISSN/ISBN
0091-6765
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Copper is an essential trace element that may cause intoxication if intake becomes excessive. Young children are at risk of intoxication because of high consumption of drinking water and immature copper metabolism. The aims of this prospective study were to estimate concentrations of copper in drinking water, volumes of drinking water consumed by children, and children's daily intake of copper. Concentrations of copper in unflushed drinking water were analyzed for 1178 children living in Uppsala and Malmo, Sweden, and concentrations and amounts of copper consumed from drinking water were estimated for 430 of these children, 9-21 months of age. The study children were from Swedish families, were not enrolled in publicly provided day care, and were not breast-fed more than three times a day. In the initial population, the 10th percentile for copper concentration in unflushed drinking water was 0.17 mg/L, the median was 0.72 mg/L, and the 90th percentile was 2.11 mg/L. In the subpopulation of 430 children, the 10th percentile for daily intake of copper from drinking water was 0.03 mg/L, the median was 0.32 mg/L, and the 90th percentile was 1.07 mg/L. The median daily intake of copper from drinking water was higher in Uppsala, at 0.46 mg, than in Malmo, at 0.26 mg. For groups of children,whose families took part in a later prospective diary study, the copper concentration in consumed water could, to some extent, be predicted from the concentration of copper in unflushed drinking water. The lowest concentrations of copper in drinking water were found in households with old water-pipe systems and in those living in detached houses. A large proportion of the young children satisfied their daily requirement of copper solely from drinking water. About 10% of the children had a copper intake above the level recommended by the World Health Organization.
Descriptors
copper, drinking water, article, copper metabolism, dietary intake, housing, human, human experiment, infant, intoxication, normal human, preschool child, priority journal, Sweden
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Pettersson,R., Rasmussen,F.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Deaths in swine by a lightning strike in the sty 1991 Appel, G., Tierärztlichen Ambulanz Schwarzenbek, Fachbereich Veterinärmedizin der Freien Universität Berlin.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
DTW.Deutsche tierärztliche Wochenschrift
Periodical, Abbrev.
DTW.Dtsch.Tierarztl.Wochenschr.
Pub Date Free Form
/
Volume
98
Issue
5
Start Page
187
Other Pages
190
Notes
Place of Publication
ISSN/ISBN
0341-6593
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
It is reported on deaths of pigs due to lightning stroke in the barn. During a severe thunder storm 11 clinically healthy pigs with an average weight of approx. 22 kg died simultaneously and suddenly in the barn. The animals were kept on a floor of metal slats. The pens were separated by metal bars. A water pipe leading into the barn from outside had contact to the bars. Two pigs were submitted for an examination approx. three hours post mortem. The macroscopic and microscopic necropsy findings are described.
Descriptors
metal, animal, animal disease, animal housing, article, electric injury, injury, male, mortality, pathology, sudden death, pig
Links
Book Title
Todesfälle bei Schweinen durch Blitzschlag im Stall.
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Appel,G.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Decomposition and nitrogen dynamics of (15)N-labeled leaf, root, and twig litter in temperate coniferous forests 2013 Department of Forest Ecosystems and Society, Oregon State University, 321 Richardson Hall, Corvallis, OR, 97331, USA, tiff.vanhuysen@gmail.com.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Oecologia
Periodical, Abbrev.
Oecologia
Pub Date Free Form
Dec
Volume
173
Issue
4
Start Page
1563
Other Pages
1573
Notes
JID: 0150372; 0 (Nitrogen Isotopes); 0 (Soil); N762921K75 (Nitrogen); 2012/07/02 [received]; 2013/06/06 [accepted]; 2013/07/25 [aheadofprint]; ppublish
Place of Publication
Germany
ISSN/ISBN
1432-1939; 0029-8549
Accession Number
PMID: 23884664
Language
eng
SubFile
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1007/s00442-013-2706-8 [doi]
Output Language
Unknown(0)
PMID
23884664
Abstract
Litter nutrient dynamics contribute significantly to biogeochemical cycling in forest ecosystems. We examined how site environment and initial substrate quality influence decomposition and nitrogen (N) dynamics of multiple litter types. A 2.5-year decomposition study was installed in the Oregon Coast Range and West Cascades using (15)N-labeled litter from Acer macrophyllum, Picea sitchensis, and Pseudotsuga menziesii. Mass loss for leaf litter was similar between the two sites, while root and twig litter exhibited greater mass loss in the Coast Range. Mass loss was greatest from leaves and roots, and species differences in mass loss were more prominent in the Coast Range. All litter types and species mineralized N early in the decomposition process; only A. macrophyllum leaves exhibited a net N immobilization phase. There were no site differences with respect to litter N dynamics despite differences in site N availability, and litter N mineralization patterns were species-specific. For multiple litter x species combinations, the difference between gross and net N mineralization was significant, and gross mineralization was 7-20 % greater than net mineralization. The mineralization results suggest that initial litter chemistry may be an important driver of litter N dynamics. Our study demonstrates that greater amounts of N are cycling through these systems than may be quantified by only measuring net mineralization and challenges current leaf-based biogeochemical theory regarding patterns of N immobilization and mineralization.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
van Huysen,T.L., Harmon,M.E., Perakis,S.S., Chen,H.
Original/Translated Title
URL
Date of Electronic
20130725
PMCID
Editors
Decompression sickness and arterial gas embolism in sports scuba divers 1989 Department of Anaesthesia, University of Adelaide, Australia.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Sports medicine (Auckland, N.Z.)
Periodical, Abbrev.
Sports Med.
Pub Date Free Form
Jul
Volume
8
Issue
1
Start Page
32
Other Pages
42
Notes
LR: 20041117; JID: 8412297; RF: 57; OID: NASA: 89388040; ppublish
Place of Publication
NEW ZEALAND
ISSN/ISBN
0112-1642; 0112-1642
Accession Number
PMID: 2675253
Language
eng
SubFile
Journal Article; Review; IM; S
DOI
Output Language
Unknown(0)
PMID
2675253
Abstract
Diving underwater with breathing apparatus is an increasingly popular sport. Consequently, the number of diving-related accidents, including both decompression sickness and arterial gas embolism, have increased. Though both involve bubbles, decompression sickness is a disease which involves gas bubbles forming in tissues and venous blood, while arterial gas embolism results from the introduction of gas bubbles directly into the arterial circulation. Although the pathologies and natural histories of decompression sickness and arterial gas embolism are different, the treatment of these conditions is essentially the same. Compression in a recompression chamber is the definitive treatment of both decompression sickness and arterial gas embolism, and any delay before treatment must be minimised if a good outcome is desired.
Descriptors
Arteries, Decompression Sickness/etiology, Diving, Embolism, Air/etiology, Humans
Links
Book Title
Database
Publisher
Data Source
Authors
Gorman,D. F.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Decompression sickness in breath-hold diving, and its probable connection to the growth and dissolution of small arterial gas emboli 2015 Department of Chemistry, the Guelph-Waterloo Centre for Graduate Work in Chemistry and the Guelph-Waterloo Physics Institute University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: sgoldman@uoguelph.ca.; Department of Chemistry, the Gue
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Mathematical biosciences
Periodical, Abbrev.
Math.Biosci.
Pub Date Free Form
Apr
Volume
262
Issue
Start Page
1
Other Pages
9
Notes
CI: Copyright (c) 2015; JID: 0103146; OTO: NOTNLM; 2014/10/28 [received]; 2015/01/05 [accepted]; 2015/01/15 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1879-3134; 0025-5564
Accession Number
PMID: 25598211
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.mbs.2015.01.001 [doi]
Output Language
Unknown(0)
PMID
25598211
Abstract
We solved the Laplace equation for the radius of an arterial gas embolism (AGE), during and after breath-hold diving. We used a simple three-region diffusion model for the AGE, and applied our results to two types of breath-hold dives: single, very deep competitive-level dives and repetitive shallower breath-hold dives similar to those carried out by indigenous commercial pearl divers in the South Pacific. Because of the effect of surface tension, AGEs tend to dissolve in arterial blood when arteries remote from supersaturated tissue. However if, before fully dissolving, they reach the capillary beds that perfuse the brain and the inner ear, they may become inflated with inert gas that is transferred into them from these contiguous temporarily supersaturated tissues. By using simple kinetic models of cerebral and inner ear tissue, the nitrogen tissue partial pressures during and after the dive(s) were determined. These were used to theoretically calculate AGE growth and dissolution curves for AGEs lodged in capillaries of the brain and inner ear. From these curves it was found that both cerebral and inner ear decompression sickness are expected to occur occasionally in single competitive-level dives. It was also determined from these curves that for the commercial repetitive dives considered, the duration of the surface interval (the time interval separating individual repetitive dives from one another) was a key determinant, as to whether inner ear and/or cerebral decompression sickness arose. Our predictions both for single competitive-level and repetitive commercial breath-hold diving were consistent with what is known about the incidence of cerebral and inner ear decompression sickness in these forms of diving.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Inc
Data Source
Authors
Goldman,S., Solano-Altamirano,J.M.
Original/Translated Title
URL
Date of Electronic
20150115
PMCID
Editors
DECOY: Documenting Experiences with Cigarettes and Other Tobacco in Young Adults 2016 Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA, USA. cjberg@emory.edu.; Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atla
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
American Journal of Health Behavior
Periodical, Abbrev.
Am.J.Health Behav.
Pub Date Free Form
May
Volume
40
Issue
3
Start Page
310
Other Pages
321
Notes
LR: 20160612; GR: R01 CA179422/CA/NCI NIH HHS/United States; JID: 9602338; NIHMS792145; OID: NLM: NIHMS792145; OID: NLM: PMC4903022; ppublish
Place of Publication
United States
ISSN/ISBN
1945-7359; 1087-3244
Accession Number
PMID: 27103410
Language
eng
SubFile
Journal Article; IM
DOI
10.5993/AJHB.40.3.3 [doi]
Output Language
Unknown(0)
PMID
27103410
Abstract
OBJECTIVES: We examined psychographic characteristics associated with tobacco use among Project DECOY participants. METHODS: Project DECOY is a 2-year longitudinal mixed-methods study examining risk for tobacco use among 3418 young adults across 7 Georgia colleges/universities. Baseline measures included sociodemographics, tobacco use, and psychographics using the Values, Attitudes, and Lifestyle Scale. Bivariate and multivariable analyses were conducted to identify correlates of tobacco use. RESULTS: Past 30-day use prevalence was: 13.3% cigarettes; 11.3% little cigars/cigarillos (LCCs); 3.6% smokeless tobacco; 10.9% e-cigarettes; and 12.2% hookah. Controlling for sociodemographics, correlates of cigarette use included greater novelty seeking (p
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Berg,C.J., Haardorfer,R., Lewis,M., Getachew,B., Lloyd,S.A., Thomas,S.F., Lanier,A., Trepanier,K., Johnston,T., Grimsley,L., Foster,B., Benson,S., Smith,A., Barr,D.B., Windle,M.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4903022
Editors