WTS database

Title	Pub Year	Author	SearchLink Sort ascending
Risk factors for exclusive e-cigarette use and dual e-cigarette use and tobacco use in adolescents	2015	University of Hawaii Cancer Center, Honolulu, Hawaii; Twills@cc.hawaii.edu.; University of Hawaii Cancer Center, Honolulu, Hawaii;; University of Hawaii at Manoa, Honolulu, Hawaii; and.; University of Hawaii Cancer Center, Honolulu, Hawaii;; Norris Cotton	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pediatrics Periodical, Abbrev. Pediatrics Pub Date Free Form Jan Volume 135 Issue 1 Start Page e43 Other Pages 51 Notes LR: 20160128; CI: Copyright (c) 2015; GR: P30 CA023108/CA/NCI NIH HHS/United States; GR: P30 CA071789/CA/NCI NIH HHS/United States; GR: R01 CA153154/CA/NCI NIH HHS/United States; GR: U54 MD007584/MD/NIMHD NIH HHS/United States; JID: 0376422; OID: NLM: PMC Place of Publication United States ISSN/ISBN 1098-4275; 0031-4005 Accession Number PMID: 25511118 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; AIM; IM DOI 10.1542/peds.2014-0760 [doi] Output Language Unknown(0) PMID 25511118 Abstract OBJECTIVE: To describe electronic cigarette (e-cigarette) use and cigarette use among adolescents and determine whether established risk factors for smoking discriminate user categories. METHODS: School-based survey of 1941 high school students (mean age 14.6 years) in Hawaii; data collected in 2013. The survey assessed e-cigarette use and cigarette use, alcohol and marijuana use, and psychosocial risk and protective variables (eg, parental support, academic involvement, smoking expectancies, peer smoking, sensation seeking). Analysis of variance and multinomial regression examined variation in risk and protective variables across the following categories of ever-use: e-cigarette only, cigarette only, dual use (use of both products), and nonuser (never used either product). RESULTS: Prevalence for the categories was 17% (e-cigarettes only), 12% (dual use), 3% (cigarettes only), and 68% (nonusers). Dual users and cigarette-only users were highest on risk status (elevated on risk factors and lower on protective factors) compared with other groups. E-cigarette only users were higher on risk status than nonusers but lower than dual users. E-cigarette only users and dual users more often perceived e-cigarettes as healthier than cigarettes compared with nonusers. CONCLUSIONS: This study reports a US adolescent sample with one of the largest prevalence rates of e-cigarette only use in the existing literature. Dual use also had a substantial prevalence. The fact that e-cigarette only users were intermediate in risk status between nonusers and dual users raises the possibility that e-cigarettes are recruiting medium-risk adolescents, who otherwise would be less susceptible to tobacco product use. Descriptors Links Book Title Database Publisher by the American Academy of Pediatrics Data Source Authors Wills,T.A., Knight,R., Williams,R.J., Pagano,I., Sargent,J.D. Original/Translated Title URL Date of Electronic 20141215 PMCID PMC4279062 Editors
Clinical inquiries regarding Ebola virus disease received by CDC--United States, July 9-November 15, 2014	2014		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full MMWR.Morbidity and mortality weekly report Periodical, Abbrev. MMWR Morb.Mortal.Wkly.Rep. Pub Date Free Form 12-Dec Volume 63 Issue 49 Start Page 1175 Other Pages 1179 Notes LR: 20150211; JID: 7802429; ppublish Place of Publication United States ISSN/ISBN 1545-861X; 0149-2195 Accession Number PMID: 25503923 Language eng SubFile Journal Article; IM DOI mm6349a8 [pii] Output Language Unknown(0) PMID 25503923 Abstract Since early 2014, there have been more than 6,000 reported deaths from Ebola virus disease (Ebola), mostly in Guinea, Liberia, and Sierra Leone. On July 9, 2014, CDC activated its Emergency Operations Center for the Ebola outbreak response and formalized the consultation service it had been providing to assist state and local public health officials and health care providers evaluate persons in the United States thought to be at risk for Ebola. During July 9-November 15, CDC responded to clinical inquiries from public health officials and health care providers from 49 states and the District of Columbia regarding 650 persons thought to be at risk. Among these, 118 (18%) had initial signs or symptoms consistent with Ebola and epidemiologic risk factors placing them at risk for infection, thereby meeting the definition of persons under investigation (PUIs). Testing was not always performed for PUIs because alternative diagnoses were made or symptoms resolved. In total, 61 (9%) persons were tested for Ebola virus, and four, all of whom met PUI criteria, had laboratory-confirmed Ebola. Overall, 490 (75%) inquiries concerned persons who had neither traveled to an Ebola-affected country nor had contact with an Ebola patient. Appropriate medical evaluation and treatment for other conditions were noted in some instances to have been delayed while a person was undergoing evaluation for Ebola. Evaluating and managing persons who might have Ebola is one component of the overall approach to domestic surveillance, the goal of which is to rapidly identify and isolate Ebola patients so that they receive appropriate medical care and secondary transmission is prevented. Health care providers should remain vigilant and consult their local and state health departments and CDC when assessing ill travelers from Ebola-affected countries. Most of these persons do not have Ebola; prompt diagnostic assessments, laboratory testing, and provision of appropriate care for other conditions are essential for appropriate patient care and reflect hospital preparedness. Descriptors Links Book Title Database Publisher Data Source Authors Karwowski,M.P., Meites,E., Fullerton,K.E., Stroher,U., Lowe,L., Rayfield,M., Blau,D.M., Knust,B., Gindler,J., Van Beneden,C., Bialek,S.R., Mead,P., Oster,A.M., Centers for Disease Control and Prevention (CDC) Original/Translated Title URL Date of Electronic PMCID Editors
Rapid assessment of Ebola infection prevention and control needs--six districts, Sierra Leone, October 2014	2014		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full MMWR.Morbidity and mortality weekly report Periodical, Abbrev. MMWR Morb.Mortal.Wkly.Rep. Pub Date Free Form 12-Dec Volume 63 Issue 49 Start Page 1172 Other Pages 1174 Notes JID: 7802429; ppublish Place of Publication United States ISSN/ISBN 1545-861X; 0149-2195 Accession Number PMID: 25503922 Language eng SubFile Journal Article; IM DOI mm6349a7 [pii] Output Language Unknown(0) PMID 25503922 Abstract As of October 31, 2014, the Sierra Leone Ministry of Health and Sanitation had reported 3,854 laboratory-confirmed cases of Ebola virus disease (Ebola) since the outbreak began in May 2014; 199 (5.2%) of these cases were among health care workers. Ebola infection prevention and control (IPC) measures are essential to interrupt Ebola virus transmission and protect the health workforce, a population that is disproportionately affected by Ebola because of its increased risk of exposure yet is essential to patient care required for outbreak control and maintenance of the country's health system at large. To rapidly identify existing IPC resources and high priority outbreak response needs, an assessment by CDC Ebola Response Team members was conducted in six of the 14 districts in Sierra Leone, consisting of health facility observations and structured interviews with key informants in facilities and government district health management offices. Health system gaps were identified in all six districts, including shortages or absence of trained health care staff, personal protective equipment (PPE), safe patient transport, and standardized IPC protocols. Based on rapid assessment findings and key stakeholder input, priority IPC actions were recommended. Progress has since been made in developing standard operating procedures, increasing laboratory and Ebola treatment capacity and training the health workforce. However, further system strengthening is needed. In particular, a successful Ebola outbreak response in Sierra Leone will require an increase in coordinated and comprehensive district-level IPC support to prevent ongoing Ebola virus transmission in household, patient transport, and health facility settings. Descriptors Links Book Title Database Publisher Data Source Authors Pathmanathan,I., O'Connor,K.A., Adams,M.L., Rao,C.Y., Kilmarx,P.H., Park,B.J., Mermin,J., Kargbo,B., Wurie,A.H., Clarke,K.R., Centers for Disease Control and Prevention (CDC) Original/Translated Title URL Date of Electronic PMCID Editors
State laws prohibiting sales to minors and indoor use of electronic nicotine delivery systems--United States, November 2014	2014		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full MMWR.Morbidity and mortality weekly report Periodical, Abbrev. MMWR Morb.Mortal.Wkly.Rep. Pub Date Free Form 12-Dec Volume 63 Issue 49 Start Page 1145 Other Pages 1150 Notes LR: 20151119; JID: 7802429; 0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine); EIN: MMWR Morb Mortal Wkly Rep. 2014 Dec 19;63(50):1212; ppublish Place of Publication United States ISSN/ISBN 1545-861X; 0149-2195 Accession Number PMID: 25503916 Language eng SubFile Journal Article; IM DOI mm6349a1 [pii] Output Language Unknown(0) PMID 25503916 Abstract Electronic nicotine delivery systems (ENDS), including electronic cigarettes (e-cigarettes) and other devices such as electronic hookahs, electronic cigars, and vape pens, are battery-powered devices capable of delivering aerosolized nicotine and additives to the user. Experimentation with and current use of e-cigarettes has risen sharply among youths and adults in the United States. Youth access to and use of ENDS is of particular concern given the potential adverse effects of nicotine on adolescent brain development. Additionally, ENDS use in public indoor areas might passively expose bystanders (e.g., children, pregnant women, and other nontobacco users) to nicotine and other potentially harmful constituents. ENDS use could have the potential to renormalize tobacco use and complicate enforcement of smoke-free policies. State governments can regulate the sales of ENDS and their use in indoor areas where nonusers might be involuntarily exposed to secondhand aerosol. To learn the current status of state laws regulating the sales and use of ENDS, CDC assessed state laws that prohibit ENDS sales to minors and laws that include ENDS use in conventional smoking prohibitions in indoor areas of private worksites, restaurants, and bars. Findings indicate that as of November 30, 2014, 40 states prohibited ENDS sales to minors, but only three states prohibited ENDS use in private worksites, restaurants, and bars. Of the 40 states that prohibited ENDS sales to minors, 21 did not prohibit ENDS use or conventional smoking in private worksites, restaurants, and bars. Three states had no statewide laws prohibiting ENDS sales to minors and no statewide laws prohibiting ENDS use or conventional smoking in private worksites, restaurants, and bars. According to the Surgeon General, ENDS have the potential for public health harm or public health benefit. The possibility of public health benefit from ENDS could arise only if 1) current smokers use these devices to switch completely from combustible tobacco products and 2) the availability and use of combustible tobacco products are rapidly reduced. Therefore, when addressing potential public health harms associated with ENDS, it is important to simultaneously uphold and accelerate strategies found by the Surgeon General to prevent and reduce combustible tobacco use, including tobacco price increases, comprehensive smoke-free laws, high-impact media campaigns, barrier-free cessation treatment and services, and comprehensive statewide tobacco control programs. Descriptors Links Book Title Database Publisher Data Source Authors Marynak,K., Holmes,C.B., King,B.A., Promoff,G., Bunnell,R., McAfee,T., Centers for Disease Control and Prevention (CDC) Original/Translated Title URL Date of Electronic PMCID Editors
Prevalence of Hookah smoking in relation to religiosity and familial support in college students of Tabriz, northwest of Iran	2014	Department of Public Health, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran. poorasl@yahoo.com.; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.; Clinical Ps	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of research in health sciences Periodical, Abbrev. J.Res.Health.Sci. Pub Date Free Form Autumn Volume 14 Issue 4 Start Page 268 Other Pages 271 Notes LR: 20151119; JID: 101480094; OTO: NOTNLM; 2014/06/30 [received]; 2014/10/25 [accepted]; ppublish Place of Publication Iran ISSN/ISBN 2228-7809; 2228-7795 Accession Number PMID: 25503281 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 1681 [pii] Output Language Unknown(0) PMID 25503281 Abstract BACKGROUND: Hookah smoking has increased worldwide especially among youth and young adults and has been identified as an emerging threat to public health. The aim of the present study was to determine the prevalence of hookah use and related factors in a sample of Iranian college students. METHODS: This study took place in Tabriz (northwest of Iran) in April and May 2011. The randomly selected sample consisted of 1837 college students. Data was collected in a survey. A self-administered questionnaire was used to measure religious belief, parental support and risk taking behaviors including hookah smoking. Logistic regression model was performed in data analysis. RESULTS: The prevalence of hookah smoking was 8.5% (CI95%: 7.3-9.9). After adjustment, being male (OR= 2.01), living in single house in comparison with living with parents (OR= 2.22), smoking (OR= 5.96) and ever drug abuse (OR= 3.02) were factors associated with students' hookah use. CONCLUSIONS: Our results showed a low prevalence of hookah smoking in Iranian college female students and revealed some of its associated factors. We demonstrated the co-occurrence of risky behaviors which emphasizes the importance of interventions aimed at reducing or preventing different high risk behaviors simultaneously. Descriptors Links Book Title Database Publisher Data Source Authors Mohammadpoorasl,A., Abbasi Ghahramanloo,A., Allahverdipour,H., Modaresi Esfeh,J. Original/Translated Title URL Date of Electronic PMCID Editors
MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study	2014	1] Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri, USA [2] University of Kansas Medical Center, Kansas City, Kansas, USA [3] Kansas Cancer Institute, Kansas City, Kansas, USA.; Department of Molecular a	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical and translational gastroenterology Periodical, Abbrev. Clin.Transl.Gastroenterol. Pub Date Free Form 11-Dec Volume 5 Issue Start Page e65 Other Pages Notes LR: 20141231; JID: 101532142; OID: NLM: PMC4274369; 2014/08/15 [received]; 2014/11/10 [accepted]; epublish Place of Publication United States ISSN/ISBN 2155-384X Accession Number PMID: 25502391 Language eng SubFile Journal Article DOI 10.1038/ctg.2014.17 [doi] Output Language Unknown(0) PMID 25502391 Abstract OBJECTIVES: Patient outcomes for esophageal adenocarcinoma (EAC) have not improved despite huge advances in endoscopic therapy because cancers are being diagnosed late. Barrett's esophagus (BE) is the primary precursor lesion for EAC, and thus the non-endoscopic molecular diagnosis of BE can be an important approach to improve EAC outcomes if robust biomarkers for timely diagnosis are identified. MicroRNAs (miRNAs) are tissue-specific novel biomarkers that regulate gene expression and may satisfy this requirement. METHODS: Patients with gastroesophageal reflux disease (GERD) and BE were selected from an ongoing tissue and serum repository. BE was defined by the presence of intestinal metaplasia. Previously published miRNA sequencing profiles of GERD and BE patients allowed us to select three miRNAs, miR-192-5p, -215-5p, and -194-5p, for further testing in a discovery cohort and an independent validation cohort. Receiver operating curves were generated to calculate the diagnostic accuracy of these miRNAs for BE diagnosis. To test specificity, the miRNA signature was compared with those of the gastric cardia epithelium and the non-intestinal-type columnar epithelium (another definition of BE). In addition, to gain insights into BE origin (intestinal vs non-intestinal), global BE miRNA profiles were compared with the published miRNA profiles of other columnar epithelia in the gastrointestinal tract, that is, normal stomach and small and large intestine. RESULTS: The discovery cohort included 67 white male patients (40 with GERD and 27 with BE). The validation cohort included 28 patients (19 with GERD and 11 with BE). In the discovery cohort, the sensitivity, specificity and area under the curve (AUC) of the three mRNAs for BE diagnosis were 92-100%, 94-95%, and 0.96-0.97, respectively. During validation, the sensitivity and specificity of miRNAs for BE diagnosis were as follows: miR-192-5p, 92% and 94%, AUC 0.94 (0.80-0.99, P=0.0004); miR-215-5p, 100% and 94%, AUC 0.98 (0.84-1, P=0.0004); and miR-194-5p, 91% and 94%, AUC 0.96 (0.80-0.99, P=0.0001), respectively. The tested miRNAs identified all BE patients in both the discovery and the validation cohorts. When compared with non intestinal-type columnar and gastric cardia epithelia, the miRNA signature was specific to the intestinal-type columnar epithelium. Comparisons of BE miRNA sequencing data to published data sets for the normal stomach, small intestine and large intestine confirmed that two of the three miRNAs (miR-215-5p and -194-5p) were specific to the intestinal-type epithelium. CONCLUSIONS: MicroRNAs are highly accurate for detecting intestinal-type BE epithelia and should be tested further for the non-endoscopic molecular diagnosis of BE. Descriptors Links Book Title Database Publisher Data Source Authors Bansal,A., Hong,X., Lee,I.H., Krishnadath,K.K., Mathur,S.C., Gunewardena,S., Rastogi,A., Sharma,P., Christenson,L.K. Original/Translated Title URL Date of Electronic 20141211 PMCID PMC4274369 Editors
Clearing the air: improving smoke-free policy compliance at the national oncology hospital in Armenia	2014	School of Public Health, American University of Armenia, Yerevan, Armenia. nmovsesi@aua.am.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC cancer Periodical, Abbrev. BMC Cancer Pub Date Free Form 13-Dec Volume 14 Issue Start Page 943 Other Pages 2407-14-943 Notes LR: 20151028; JID: 100967800; 0 (Tobacco Smoke Pollution); OID: NLM: PMC4320561; 2014/08/04 [received]; 2014/12/08 [accepted]; 2014/12/13 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2407; 1471-2407 Accession Number PMID: 25495431 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1186/1471-2407-14-943 [doi] Output Language Unknown(0) PMID 25495431 Abstract BACKGROUND: Smoke-free policies shown to reduce population exposure to secondhand smoke (SHS) are the norm in hospitals in many countries around the world. Armenia, a transition economy in the South Caucasus, has one of the highest male smoking rates in the European region. Although smoking in healthcare facilities has been banned since 2005, compliance with this ban has been poor due to lack of implementation and enforcement mechanisms and social acceptability of smoking. The study aimed to develop and test a model intervention to address the lack of compliance with the de jure smoking ban. The national oncology hospital was chosen as the intervention site. METHODS: This study used employee surveys and objective measurements of respirable particles (PM2.5) and air nicotine as markers of indoor air pollution before and after the intervention. The intervention developed in partnership with the hospital staff included an awareness campaign on SHS hazards, creation of no-smoking environment and building institutional capacity through training of nursing personnel on basics of tobacco control. The survey analysis included paired t-test and McNemar's test. The log-transformed air nicotine and PM2.5 data were analyzed using paired t-test. RESULTS: The survey showed significant improvement in the perceived quality of indoor air, reduced worksite exposure to SHS and increased employees' awareness of the smoke-free policy. The number of employees reporting compliance with the hospital smoke-free policy increased from 36.0% to 71.9% (p Descriptors Links Book Title Database Publisher Data Source Authors Movsisyan,N.K., Petrosyan,V., Harutyunyan,A., Petrosyan,D., Stillman,F. Original/Translated Title URL Date of Electronic 20141213 PMCID PMC4320561 Editors
Waterpipe tobacco smoking: what is the evidence that it supports nicotine/tobacco dependence?	2015	Center for Clinical and Translational Research and Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, USA.; Department of Psychology, Center for the Study of Tobacco Products, Virginia Commonwealth University,	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Mar Volume 24 Suppl 1 Issue Start Page i44 Other Pages i53 Notes LR: 20150618; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; GR: P50 DA036105/DA/NIDA NIH HHS/United States; GR: P Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 25492935 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review; IM DOI 10.1136/tobaccocontrol-2014-051910 [doi] Output Language Unknown(0) PMID 25492935 Abstract OBJECTIVE: Waterpipe tobacco smoking (WTS) involves passing tobacco smoke through water prior to inhalation, and has spread worldwide. This spread becomes a public health concern if it is associated with tobacco-caused disease and if WTS supports tobacco/nicotine dependence. A growing literature demonstrates that WTS is associated with disability, disease and death. This narrative review examines if WTS supports nicotine/tobacco dependence, and is intended to help guide tobacco control efforts worldwide. DATA SOURCES: PUBMED search using: (("waterpipe" or "narghile" or "arghile" or "shisha" or "goza" or "narkeela" or "hookah" or "hubble bubble")) AND ("dependence" or "addiction"). STUDY SELECTION: Excluded were articles not in English, without original data, and that were not topic-related. Thirty-two articles were included with others identified by inspecting reference lists and other sources. DATA SYNTHESIS: WTS and the delivery of the dependence-producing drug nicotine were examined, and then the extent to which the articles addressed WTS-induced nicotine/dependence explicitly, as well as implicitly with reference to criteria for dependence outlined by the WHO. CONCLUSIONS: WTS supports nicotine/tobacco dependence because it is associated with nicotine delivery, and because some smokers experience withdrawal when they abstain from waterpipe, alter their behaviour in order to access a waterpipe and have difficulty quitting, even when motivated to do so. There is a strong need to support research investigating measurement of WTS-induced tobacco dependence, to inform the public of the risks of WTS, which include dependence, disability, disease and death, and to include WTS in the same public health policies that address tobacco cigarettes. Descriptors Links Book Title Database Publisher Data Source Authors Aboaziza,E., Eissenberg,T. Original/Translated Title URL Date of Electronic 20141209 PMCID PMC4345797 Editors
Hookah pipes are associated with young people starting smoking, study finds	2014	London.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMJ (Clinical research ed.) Periodical, Abbrev. BMJ Pub Date Free Form 8-Dec Volume 349 Issue Start Page g7546 Other Pages Notes JID: 8900488; epublish Place of Publication England ISSN/ISBN 1756-1833; 0959-535X Accession Number PMID: 25491109 Language eng SubFile News; AIM; IM DOI 10.1136/bmj.g7546 [doi] Output Language Unknown(0) PMID 25491109 Abstract Descriptors Links Book Title Database Publisher Data Source Authors Wise,J. Original/Translated Title URL Date of Electronic 20141208 PMCID Editors
Role of Cigarette Smoke-Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis	2015	Departments of 1 Pediatric Respiratory Science and.; 2 Biomedical Engineering, the Johns Hopkins University School of Medicine, Baltimore, Maryland; and.; Departments of 1 Pediatric Respiratory Science and.; 2 Biomedical Engineering, the Johns Hopkins Uni	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American journal of respiratory cell and molecular biology Periodical, Abbrev. Am.J.Respir.Cell Mol.Biol. Pub Date Free Form Aug Volume 53 Issue 2 Start Page 159 Other Pages 173 Notes GR: R01HL59410-04/HL/NHLBI NIH HHS/United States; GR: U54CA141868/CA/NCI NIH HHS/United States; JID: 8917225; 0 (Cell Cycle Proteins); 0 (P62 protein, human); 0 (RNA-Binding Proteins); 0 (Ubiquitinated Proteins); EC 3.6.1.- (Adenosine Triphosphatases); EC Place of Publication United States ISSN/ISBN 1535-4989; 1044-1549 Accession Number PMID: 25490051 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1165/rcmb.2014-0107OC [doi] Output Language Unknown(0) PMID 25490051 Abstract Cigarette smoke (CS) exposure is known to induce proteostasis imbalance that can initiate accumulation of ubiquitinated proteins. Therefore, the primary goal of this study was to determine if first- and secondhand CS induces localization of ubiquitinated proteins in perinuclear spaces as aggresome bodies. Furthermore, we sought to determine the mechanism by which smoke-induced aggresome formation contributes to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Hence, Beas2b cells were treated with CS extract (CSE) for in vitro experimental analysis of CS-induced aggresome formation by immunoblotting, microscopy, and reporter assays, whereas chronic CS-exposed murine model and human COPD-emphysema lung tissues were used for validation. In preliminary analysis, we observed a significant (P Descriptors Links Book Title Database Publisher Data Source Authors Tran,I., Ji,C., Ni,I., Min,T., Tang,D., Vij,N. Original/Translated Title URL Date of Electronic PMCID Editors

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