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Smoking topography: reliability and validity in dependent smokers 2003 National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore MD 21224, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Oct
Volume
5
Issue
5
Start Page
673
Other Pages
679
Notes
LR: 20131121; GR: P50CA84718/CA/NCI NIH HHS/United States; JID: 9815751; 7U1EE4V452 (Carbon Monoxide); ppublish
Place of Publication
England
ISSN/ISBN
1462-2203; 1462-2203
Accession Number
PMID: 14577984
Language
eng
SubFile
Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.; IM
DOI
20TYV58QGN587M46 [pii]
Output Language
Unknown(0)
PMID
14577984
Abstract
Data from two studies were analyzed to determine whether smoking through the mouthpiece of a topography unit yields consistent measures over time and to verify that smoking through a mouthpiece results in a similar degree of smoke exposure as conventional smoking. In both studies, subjects smoked their usual brand of cigarette ad libitum. In study A, subjects (n=7) smoked through a mouthpiece on 4 separate experimental days. In study B, subjects (n=10) smoked on 2 separate days: Once conventionally and once through a mouthpiece. In both studies, exhaled carbon monoxide (CO) and physiological effects (heart rate and blood pressure) were measured before and after smoking. In study B, plasma nicotine concentrations also were measured. In study A, puff volume, puff duration, interpuff interval, and maximum puff velocity averaged 30.8 ml,.9 s, 19.9 s, and 44.6 ml/s, respectively. Intraclass correlation coefficients computed for puff volume (0.66), puff duration (0.75), and maximum puff velocity (0.68) indicated that these measures showed good reliability. In study B, smoking through the mouthpiece yielded similar topographical (time to smoke and number of puffs per cigarette) measures as conventional smoking. Also similar were changes in biochemical values: Plasma nicotine (18.5 ng/ml vs. 25.5 ng/ml), exhaled CO (4.6 ppm vs. 5.1 ppm), and heart rate (8.6 beats/min vs. 7.4 beats/min) for conventional and topography mouthpiece smoking conditions, respectively. Topography measures did not differ significantly between the two studies. Overall, the data from these two small-sample studies suggest that smoking topography provides a valid and reliable index of conventional smoking and an indirect measure of smoke exposure.
Descriptors
Adult, Blood Pressure, Carbon Monoxide/analysis, Equipment Design, Female, Heart Rate, Humans, Male, Models, Theoretical, Reproducibility of Results, Sensitivity and Specificity, Smoking, Tobacco Use Disorder
Links
Book Title
Database
Publisher
Data Source
Authors
Lee,E. M., Malson,J. L., Waters,A. J., Moolchan,E. T., Pickworth,W. B.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Quantitative comparisons between a nicotine delivery device (Eclipse) and conventional cigarette smoking 2004 National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Feb
Volume
6
Issue
1
Start Page
95
Other Pages
102
Notes
LR: 20151119; GR: 5-P50-CA84718/CA/NCI NIH HHS/United States; JID: 9815751; 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); ppublish
Place of Publication
England
ISSN/ISBN
1462-2203; 1462-2203
Accession Number
PMID: 14982693
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; IM
DOI
10.1080/14622200310001656911 [doi]
Output Language
Unknown(0)
PMID
14982693
Abstract
In 1997, R. J. Reynolds introduced Eclipse, a nicotine delivery device (NDD) purported to deliver lower levels of smoke than conventional cigarettes. This NDD uses a carbon fuel element to vaporize the nicotine in the rod; the user then inhales the nicotine vapor. In the present study, the effects of this NDD on smoking topography; substance delivery factors; and physiological, subjective, and biochemical markers of smoking were compared with commercial cigarettes (referred to as Own Brand). All smoking occurred ad lib with the cigarette or NDD hand-held (conventional) or held in a topography mouthpiece. A total of 10 adults (seven males) smoked on five occasions: NDD conventional, NDD topography, Own Brand conventional, Own Brand topography (twice). Sessions were separated by at least 24 hr. Measures were taken before and 2, 5, 10, 15, 30, and 60 min after smoking. The NDD took longer to smoke (366 s vs. 292 s), required more puffs (14.8 vs. 10.8), and caused a larger increase in exhaled carbon monoxide (CO; 7.3 ppm vs. 4.2 ppm) than Own Brand. However, venous plasma nicotine boost was significantly larger 2 min after smoking Own Brand as compared with the NDD (16.4 ng/ml vs. 10.7 ng/ml). Puff volume (90.7 ml vs. 63.0 ml) and puff velocity (81.6 ml/s vs. 58.2 ml/s) were greater after the NDD than Own Brand, whereas inter-puff interval and puff duration were similar. Subjects rated the NDD as less satisfying (5.2 vs. 9.8), less rewarding (9.5 vs. 14.3), and more aversive (5.0 vs. 3.1) than their own brand. The results of this study indicate that this NDD exposes the user to significant quantities of nicotine, CO, and possibly other harmful components of tobacco smoke. The findings further validate the use of a topography device as an effective instrument to quantify smoke exposure.
Descriptors
Adult, Blood Pressure/drug effects, Carbon Monoxide/analysis, Equipment Design, Female, Heart Rate/drug effects, Humans, Male, Middle Aged, Nicotine/administration & dosage/adverse effects/blood, Smoking Cessation/methods, Tobacco Use Disorder/epidemiology, Volatilization
Links
Book Title
Database
Publisher
Data Source
Authors
Lee,E. M., Malson,J. L., Moolchan,E. T., Pickworth,W. B.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Early adolescent patterns of alcohol, cigarettes, and marijuana polysubstance use and young adult substance use outcomes in a nationally representative sample 2014 National Institute on Alcohol Abuse and Alcoholism, United States. Electronic address: psych.hmossmd@gmail.com.; Alcohol Epidemiologic Data System, CSR, Incorporated, United States.; Alcohol Epidemiologic Data System, CSR, Incorporated, United States.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Drug and alcohol dependence
Periodical, Abbrev.
Drug Alcohol Depend.
Pub Date Free Form
1-Mar
Volume
136
Issue
Start Page
51
Other Pages
62
Notes
CI: Published by Elsevier Ireland Ltd.; JID: 7513587; OTO: NOTNLM; 2013/07/30 [received]; 2013/12/09 [revised]; 2013/12/14 [accepted]; 2013/12/31 [aheadofprint]; ppublish
Place of Publication
Ireland
ISSN/ISBN
1879-0046; 0376-8716
Accession Number
PMID: 24434016
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1016/j.drugalcdep.2013.12.011 [doi]
Output Language
Unknown(0)
PMID
24434016
Abstract
BACKGROUND: Alcohol, tobacco and marijuana are the most commonly used drugs by adolescents in the U.S. However, little is known about the patterning of early adolescent substance use, and its implications for problematic involvement with substances in young adulthood. We examined patterns of substance use prior to age 16, and their associations with young adult substance use behaviors and substance use disorders in a nationally representative sample of U.S. adolescents. METHOD: Using data from Wave 4 of the Add Health Survey (n=4245), we estimated the prevalence of various patterns of early adolescent use of alcohol, cigarettes, and marijuana use individually and in combination. Then we examined the effects of patterns of early use of these substances on subsequent young adult substance use behaviors and DSM-IV substance use disorders. RESULTS: While 34.4% of individuals reported no substance use prior to age 16, 34.1% reported either early use of both alcohol and marijuana or alcohol, marijuana and cigarettes, indicating the relatively high prevalence of this type of polysubstance use behavior among U.S. adolescents. Early adolescent use of all three substances was most strongly associated with a spectrum of young adult substance use problems, as well as DSM-IV substance use disorder diagnoses. CONCLUSIONS: This research confirms the elevated prevalence and importance of polysubstance use behavior among adolescents prior to age 16, and puts early onset of alcohol, marijuana and cigarette use into the context of use patterns rather than single drug exposures.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Moss,H.B., Chen,C.M., Yi,H.Y.
Original/Translated Title
URL
Date of Electronic
20131231
PMCID
Editors
Quality assessment of Romanian bottled mineral water and tap water 2016 National Institute of R&D for Optoelectronics, Atomistilor 409, RO-077125, Magurele, Romania. elfrida.carstea@inoe.ro.; National Institute of R&D for Optoelectronics, Research Institute for Analytical Instrumentation Subsidiary, Donath 67, 400293, Cluj-Na
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environmental monitoring and assessment
Periodical, Abbrev.
Environ.Monit.Assess.
Pub Date Free Form
Sep
Volume
188
Issue
9
Start Page
521
Other Pages
016-5531-9. Epub 2016 Aug 15
Notes
JID: 8508350; OTO: NOTNLM; 2016/02/23 [received]; 2016/08/03 [accepted]; 2016/08/15 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1573-2959; 0167-6369
Accession Number
PMID: 27526046
Language
eng
SubFile
Journal Article; IM
DOI
10.1007/s10661-016-5531-9 [doi]
Output Language
Unknown(0)
PMID
27526046
Abstract
This study reports the evaluation of bottled mineral water characteristics using fluorescence spectroscopy (synchronous fluorescence scans and emission spectra) and physico-chemical analyses. Samples from 14 still mineral water brands were compared to 11 tap waters collected from two Romanian cities. Correlation and factor analyses were undertaken to understand the relationships between the individual components. The concentration of major and minor ions showed great variation between the bottled mineral water samples highlighting the diversity of the water intakes, while in the case of tap water the chemical composition was relatively similar for samples collected in the same city. Fluorescence data showed that the mineral water contained low quantities of organic matter. The humic fraction was dominant in all samples, while the microbial fraction was low in most samples. Synchronous fluorescence scans provided more information, regarding the composition of organic matter, compared to emission spectra. The study evidenced the correlation between fluorescence parameters and major elements and highlighted the potential of using fluorescence for qualitative evaluation of the bottled mineral water quality, as a screening method before undertaking complex analyses.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
M Carstea,E., Levei,E.A., Hoaghia,M.A., Savastru,R.
Original/Translated Title
URL
Date of Electronic
20160815
PMCID
Editors
Airborne exposure and biological monitoring of bar and restaurant workers before and after the introduction of a smoking ban 2006 National Institute of Occupational Health, P.O. Box 8149 Dep, N-0033, Oslo, Norway. dag.ellingsen@stami.no
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of environmental monitoring : JEM
Periodical, Abbrev.
J.Environ.Monit.
Pub Date Free Form
Mar
Volume
8
Issue
3
Start Page
362
Other Pages
368
Notes
LR: 20151119; JID: 100968688; 0 (Air Pollutants, Occupational); 0 (Dust); 0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine); K5161X06LL (Cotinine); 2006/02/20 [aheadofprint]; 2006/03/09 [epublish]; ppublish
Place of Publication
England
ISSN/ISBN
1464-0325; 1464-0325
Accession Number
PMID: 16528420
Language
eng
SubFile
Journal Article; IM
DOI
10.1039/b600050a [doi]
Output Language
Unknown(0)
PMID
16528420
Abstract
The aims were to assess the impact of a total smoking ban on the level of airborne contaminants and the urinary cotinine levels in the employees in bars and restaurants. In a follow up design, 13 bars and restaurants were visited before and after the implementation of a smoking ban. Ninety-three employees in the establishments were initially included into the study. The arithmetic mean concentration of nicotine and total dust declined from 28.3 microg m(-3) (range, 0.4-88.0) and 262 microg m(-3) (range, 52-662), respectively, to 0.6 microg m(-3) (range, not detected-3.7) and 77 microg m(-3) (range, not detected-261) after the smoking ban. The Pearson correlation coefficient between airborne nicotine and total dust was 0.86 (p < 0.001; n = 48). The post-shift geometric mean urinary cotinine concentration declined from 9.5 microg g(-1) creatinine (cr) (95% CI 6.5-13.7) to 1.4 microg g(-1) cr (95% CI 0.8-2.5) after the ban (p < 0.001) in 25 non-snuffing non-smokers. A reduction from 1444 microg g(-1) cr (95% CI 957-2180) to 688 microg g(-1) cr (95% CI 324-1458) was found (p < 0.05) in 29 non-snuffing smokers. The urinary cotinine levels increased from 11.7 microg g(-1) cr (95% CI 7.0-19.6) post-shift to 21.9 microg g(-1) cr (95% CI 13.3-36.3) (p < 0.01) in the next morning in 24 non-snuffing non-smokers before the smoking ban. A substantial reduction of airborne nicotine and total dust was observed after the introduction of a smoking ban in bars and restaurants. The urinary cotinine levels were reduced in non-smokers. The decline found in smokers may suggest a reduction in the amount of smoking after intervention. In non-smokers cotinine concentrations were higher based on urine sampled the morning after a shift than based on urine sampled immediately post-shift.
Descriptors
Adult, Air Pollutants, Occupational/analysis, Chromatography, High Pressure Liquid, Cotinine/urine, Dust/analysis, Environmental Monitoring, Female, Humans, Male, Middle Aged, Nicotine/analysis, Norway, Occupational Exposure/analysis, Public Facilities/legislation & jurisprudence, Restaurants, Smoking/legislation & jurisprudence, Time Factors, Tobacco Smoke Pollution/analysis/legislation & jurisprudence
Links
Book Title
Database
Publisher
Data Source
Authors
Ellingsen,D. G., Fladseth,G., Daae,H. L., Gjolstad,M., Kjaerheim,K., Skogstad,M., Olsen,R., Thorud,S., Molander,P.
Original/Translated Title
URL
Date of Electronic
20060220
PMCID
Editors
Natural populations of lactic acid bacteria associated with silage fermentation as determined by phenotype, 16S ribosomal RNA and recA gene analysis 2011 National Institute of Livestock and Grassland Science, Nasushiobara 329-2793, Japan.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Systematic and applied microbiology
Periodical, Abbrev.
Syst.Appl.Microbiol.
Pub Date Free Form
May
Volume
34
Issue
3
Start Page
235
Other Pages
241
Notes
LR: 20151119; CI: Copyright (c) 2011; GENBANK/AB572027; GENBANK/AB572028; GENBANK/AB572029; GENBANK/AB572030; GENBANK/AB572031; GENBANK/AB572032; GENBANK/AB572033; GENBANK/AB572034; GENBANK/AB572035; GENBANK/AB572036; GENBANK/AB572037; GENBANK/AB572038; G
Place of Publication
Germany
ISSN/ISBN
1618-0984; 0723-2020
Accession Number
PMID: 21282025
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.syapm.2010.10.003 [doi]
Output Language
Unknown(0)
PMID
21282025
Abstract
One hundred and fifty-six strains isolated from corn (Zea mays L.), forage paddy rice (Oryza sativa L.), sorghum (Sorghum bicolor L.) and alfalfa (Medicago sativa L.) silages prepared on dairy farms were screened, of which 110 isolates were considered to be lactic acid bacteria (LAB) according to their Gram-positive and catalase-negative characteristics and, mainly, the lactic acid metabolic products. These isolates were divided into eight groups (A-H) based on the following properties: morphological and biochemical characteristics, gamma-aminobutyric acid production capacity, and 16S rRNA gene sequences. They were identified as Weissella cibaria (36.4%), Weissella confusa (9.1%), Leuconostoc citreum (5.3%), Leuconostoc lactis (4.9%), Leuconostoc pseudomesenteroides (8.0%), Lactococcus lactis subsp. lactis (4.5%), Lactobacillus paraplantarum (4.5%) and Lactobacillus plantarum (27.3%). W. cibaria and W. confusa were mainly present in corn silages, and L. plantarum was dominant on sorghum and forage paddy rice silages, while L. pseudomesenteroides, L. plantarum and L. paraplantarum were the dominant species in alfalfa silage. The corn, sorghum and forage paddy rice silages were well preserved with lower pH values and ammonia-N concentrations, but had higher lactic acid content, while the alfalfa silage had relatively poor quality with higher pH values and ammonia-N concentrations, and lower lactic acid content. The present study confirmed the diversity of LAB species inhabiting silages. It showed that the differing natural populations of LAB on these silages might influence fermentation quality. These results will enable future research on the relationship between LAB species and silage fermentation quality, and will enhance the screening of appropriate inoculants aimed at improving such quality.
Descriptors
Links
Book Title
Database
Publisher
Elsevier GmbH
Data Source
Authors
Pang,H., Qin,G., Tan,Z., Li,Z., Wang,Y., Cai,Y.
Original/Translated Title
URL
Date of Electronic
20110201
PMCID
Editors
Mobile phone-based interventions for smoking cessation 2012 National Institute forHealth Innovation, University of Auckland, Auckland,New Zealand. r.whittaker@nihi.auckland.ac.nz
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Cochrane database of systematic reviews
Periodical, Abbrev.
Cochrane Database Syst.Rev.
Pub Date Free Form
14-Nov
Volume
11
Issue
Start Page
CD006611
Other Pages
Notes
LR: 20160510; JID: 100909747; CIN: Evid Based Nurs. 2013 Oct;16(4):108-9. PMID: 23389384; UIN: Cochrane Database Syst Rev. 2016;4:CD006611. PMID: 27060875; epublish
Place of Publication
England
ISSN/ISBN
1469-493X; 1361-6137
Accession Number
PMID: 23152238
Language
eng
SubFile
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.1002/14651858.CD006611.pub3 [doi]
Output Language
Unknown(0)
PMID
23152238
Abstract
BACKGROUND: Innovative and effective smoking cessation interventions are required to appeal to those who are not accessing traditional cessation services. Mobile phones are widely used and are now well-integrated into the daily lives of many, particularly young adults. Mobile phones are a potential medium for the delivery of health programmes such as smoking cessation. OBJECTIVES: To determine whether mobile phone-based interventions are effective at helping people who smoke, to quit. SEARCH METHODS: For the most recent update, we searched the Cochrane Tobacco Addiction Group Specialised Register in May 2012. We also searched UK Clinical Research Network Portfolio for current projects in the UK and the ClinicalTrials register for on-going or recently completed studies. We searched through the reference lists of identified studies and attempted to contact the authors of ongoing studies, with no restrictions placed on language or publication date. SELECTION CRITERIA: We included randomized or quasi-randomized trials. Participants were smokers of any age who wanted to quit. Studies were those examining any type of mobile phone-based intervention. This included any intervention aimed at mobile phone users, based around delivery via mobile phone, and using any functions or applications that can be used or sent via a mobile phone. DATA COLLECTION AND ANALYSIS: Information on risk of bias and methodological details was extracted using a standardised form. Participants who dropped out of the trials or were lost to follow-up were considered to be smoking. We calculated risk ratios (RR) for each included study. Meta-analysis of the included studies was undertaken using the Mantel-Haenszel fixed-effect method. Where meta-analysis was not possible, summary and descriptive statistics are presented. MAIN RESULTS: Five studies with at least six month cessation outcomes were included in this review. Three studies involve a purely text messaging intervention that has been adapted over the course of these three studies for different populations and contexts. One study is a multi-arm study of a text messaging intervention and an internet QuitCoach separately and in combination. The final study involves a video messaging intervention delivered via the mobile phone. When all five studies were pooled, mobile phone interventions were shown to increase the long term quit rates compared with control programmes (RR 1.71, 95% CI 1.47 to 1.99, over 9000 participants), using a definition of abstinence of no smoking at six months since quit day but allowing up to three lapses or up to five cigarettes. Statistical heterogeneity was substantial as indicated by the I(2) statistic (I(2) = 79%), but as all included studies were similar in design, intervention and primary outcome measure, we have presented the meta-analysis in this review. AUTHORS' CONCLUSIONS: The current evidence shows a benefit of mobile phone-based smoking cessation interventions on long-term outcomes, though results were heterogenous with findings from three of five included studies crossing the line of no effect. The studies included were predominantly of text messaging interventions. More research is required into other forms of mobile phone-based interventions for smoking cessation, other contexts such as low income countries, and cost-effectiveness.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Whittaker,R., McRobbie,H., Bullen,C., Borland,R., Rodgers,A., Gu,Y.
Original/Translated Title
URL
Date of Electronic
20121114
PMCID
Editors
Author's response to: "Harmful effects form one puff of shisha-pen vapor: methodological and interpretational problems in the risk assessment analysis" 2016 National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; National Institute for Public Health and the Environment, Bilthoven, The Netherla
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tobacco induced diseases
Periodical, Abbrev.
Tob Induc Dis.
Pub Date Free Form
7-Jul
Volume
14
Issue
Start Page
21
Other Pages
016-0087-6. eCollection 2016
Notes
LR: 20160710; JID: 101201591; OID: NLM: PMC4936250; 2016 [ecollection]; 2016/04/22 [received]; 2016/06/06 [accepted]; 2016/07/07 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
2070-7266; 1617-9625
Accession Number
PMID: 27390574
Language
eng
SubFile
Journal Article
DOI
10.1186/s12971-016-0087-6 [doi]
Output Language
Unknown(0)
PMID
27390574
Abstract
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Bos,P.M., Kienhuis,A.S., Talhout,R.
Original/Translated Title
URL
Date of Electronic
20160707
PMCID
PMC4936250
Editors
Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol 2015 National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.; National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.; National Institute for Publ
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tobacco induced diseases
Periodical, Abbrev.
Tob Induc Dis.
Pub Date Free Form
27-Jun
Volume
13
Issue
1
Start Page
15
Other Pages
015-0038-7. eCollection 2015
Notes
LR: 20150701; JID: 101201591; OID: NLM: PMC4482188; OTO: NOTNLM; 2015 [ecollection]; 2014/02/17 [received]; 2015/04/25 [accepted]; 2015/06/27 [epublish]; epublish
Place of Publication
England
ISSN/ISBN
2070-7266; 1617-9625
Accession Number
PMID: 26120296
Language
eng
SubFile
Journal Article
DOI
10.1186/s12971-015-0038-7 [doi]
Output Language
Unknown(0)
PMID
26120296
Abstract
BACKGROUND: A shisha-pen is an electronic cigarette variant that is advertised to mimic the taste of a water pipe, or shisha. The aim of this study was to assess the potential harmful health effects caused by inhaling the vapor of a nicotine-free shisha-pen. METHODS: Gas chromatography analysis was performed to determine the major components in shisha-pen vapor. Risk assessment was performed using puff volumes of e-cigarettes and "normal" cigarettes and a 1-puff scenario (one-time exposure). The concentrations that reached the airways and lungs after using a shisha-pen were calculated and compared to data from published toxicity studies. RESULTS: The main components in shisha-pen vapor are propylene glycol and glycerol (54%/46%). One puff (50 to 70 mL) results in exposure of propylene glycol and glycerol of 430 to 603 mg/m(3) and 348 to 495 mg/m(3), respectively. These exposure concentrations were higher than the points of departure for airway irritation based on a human study (propylene glycol, mean concentration of 309 mg/m(3)) and a rat study (glycerol, no-observed adverse effect level of 165 mg/m(3)). CONCLUSIONS: Already after one puff of the shisha-pen, the concentrations of propylene glycol and glycerol are sufficiently high to potentially cause irritation of the airways. New products such as the shisha-pen should be detected and risks should be assessed to inform regulatory actions aimed at limiting potential harm that may be caused to consumers and protecting young people to take up smoking.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Kienhuis,A.S., Soeteman-Hernandez,L.G., Bos,P.M., Cremers,H.W., Klerx,W.N., Talhout,R.
Original/Translated Title
URL
Date of Electronic
20150627
PMCID
PMC4482188
Editors
Mobile phone-based interventions for smoking cessation 2016 National Institute for Health Innovation, University of Auckland, Tamaki Campus, Private Bag 92019, Auckland, New Zealand, 1142.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Cochrane database of systematic reviews
Periodical, Abbrev.
Cochrane Database Syst.Rev.
Pub Date Free Form
10-Apr
Volume
4
Issue
Start Page
CD006611
Other Pages
Notes
JID: 100909747; epublish
Place of Publication
England
ISSN/ISBN
1469-493X; 1361-6137
Accession Number
PMID: 27060875
Language
eng
SubFile
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.1002/14651858.CD006611.pub4 [doi]
Output Language
Unknown(0)
PMID
27060875
Abstract
BACKGROUND: Access to mobile phones continues to increase exponentially globally, outstripping access to fixed telephone lines, fixed computers and the Internet. Mobile phones are an appropriate and effective option for the delivery of smoking cessation support in some contexts. This review updates the evidence on the effectiveness of mobile phone-based smoking cessation interventions. OBJECTIVES: To determine whether mobile phone-based smoking cessation interventions increase smoking cessation in people who smoke and want to quit. SEARCH METHODS: For the most recent update, we searched the Cochrane Tobacco Addiction Group Specialised Register in April 2015. We also searched the UK Clinical Research Network Portfolio for current projects in the UK, and the ClinicalTrials.gov register for ongoing or recently completed studies. We searched through the reference lists of identified studies and attempted to contact the authors of ongoing studies. We applied no restrictions on language or publication date. SELECTION CRITERIA: We included randomised or quasi-randomised trials. Participants were smokers of any age who wanted to quit. Studies were those examining any type of mobile phone-based intervention for smoking cessation. This included any intervention aimed at mobile phone users, based around delivery via mobile phone, and using any functions or applications that can be used or sent via a mobile phone. DATA COLLECTION AND ANALYSIS: Review authors extracted information on risk of bias and methodological details using a standardised form. We considered participants who dropped out of the trials or were lost to follow-up to be smoking. We calculated risk ratios (RR) and 95% confidence intervals (CI) for each included study. Meta-analysis of the included studies used the Mantel-Haenszel fixed-effect method. Where meta-analysis was not possible, we presented a narrative summary and descriptive statistics. MAIN RESULTS: This updated search identified 12 studies with six-month smoking cessation outcomes, including seven studies completed since the previous review. The interventions were predominantly text messaging-based, although several paired text messaging with in-person visits or initial assessments. Two studies gave pre-paid mobile phones to low-income human immunodeficiency virus (HIV)-positive populations - one solely for phone counselling, the other also included text messaging. One study used text messages to link to video messages. Control programmes varied widely. Studies were pooled according to outcomes - some providing measures of continuous abstinence or repeated measures of point prevalence; others only providing 7-day point prevalence abstinence. All 12 studies pooled using their most rigorous 26-week measures of abstinence provided an RR of 1.67 (95% CI 1.46 to 1.90; I(2) = 59%). Six studies verified quitting biochemically at six months (RR 1.83; 95% CI 1.54 to 2.19). AUTHORS' CONCLUSIONS: The current evidence supports a beneficial impact of mobile phone-based smoking cessation interventions on six-month cessation outcomes. While all studies were good quality, the fact that those studies with biochemical verification of quitting status demonstrated an even higher chance of quitting further supports the positive findings. However, it should be noted that most included studies were of text message interventions in high-income countries with good tobacco control policies. Therefore, caution should be taken in generalising these results outside of this type of intervention and context.
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Whittaker,R., McRobbie,H., Bullen,C., Rodgers,A., Gu,Y.
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20160410
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