WTS database

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Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles	2013	School of Life Sciences, SRTM University, Nanded, MS 431606, India.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases Periodical, Abbrev. Braz.J.Infect.Dis. Pub Date Free Form Jul-Aug Volume 17 Issue 4 Start Page 395 Other Pages 400 Notes CI: Copyright (c) 2013; JID: 9812937; 0 (Antifungal Agents); 0 (Azoles); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 886U3H6UFF (Chloroquine); F0XDI6ZL63 (caspofungin); OTO: NOTNLM; 2012/07/26 [received]; 2012/10/31 [revised]; 2012/11/01 [accepted]; 2 Place of Publication Brazil ISSN/ISBN 1678-4391; 1413-8670 Accession Number PMID: 23602464 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.bjid.2012.11.002 [doi] Output Language Unknown(0) PMID 23602464 Abstract Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic assay were confirmed by scanning electron microscopy. The interactions between chloroquine and four antifungal drugs were determined by calculating fractional inhibitory concentration indices. Azole resistance in biofilms was reverted significantly (p Descriptors Links Book Title Database Publisher Elsevier Editora Ltda Data Source Authors Shinde,R.B., Raut,J.S., Chauhan,N.M., Karuppayil,S.M. Original/Translated Title URL Date of Electronic 20130418 PMCID Editors
Chromosomal location of blaCTX-M genes in clinical isolates of Escherichia coli from Germany, The Netherlands and the UK	2014	Federal Institute for Risk Assessment (BfR), Department for Biological Safety, Max-Dohrn Strasse 8-10, D-10589 Berlin, Germany. Electronic address: irodriguezf@salud.madrid.org.; Federal Institute for Risk Assessment (BfR), Department for Biological Safet	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full International journal of antimicrobial agents Periodical, Abbrev. Int.J.Antimicrob.Agents Pub Date Free Form Jun Volume 43 Issue 6 Start Page 553 Other Pages 557 Notes CI: Copyright (c) 2014; JID: 9111860; 0 (Cephalosporins); 0 (DNA, Bacterial); EC 3.5.2.6 (beta-Lactamases); OTO: NOTNLM; 2013/10/21 [received]; 2014/02/26 [revised]; 2014/02/26 [accepted]; 2014/04/16 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1872-7913; 0924-8579 Accession Number PMID: 24816185 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.ijantimicag.2014.02.019 [doi] Output Language Unknown(0) PMID 24816185 Abstract This study aimed to detect and characterise clinical Escherichia coli isolates suspected of carrying chromosomally encoded CTX-M enzymes. Escherichia coli (n=356) obtained in Germany, The Netherlands and the UK (2005-2009) and resistant to third-generation cephalosporins were analysed for the presence of ESBL-/AmpC-encoding genes within the European SAFEFOODERA-ESBL project. beta-Lactamases and their association with IS26 and ISEcp1 were investigated by PCR. Isolates were typed by phylogenetic grouping, MLST and PFGE. Plasmids were visualised by S1 nuclease PFGE, and the location of blaCTX-M genes was determined by Southern hybridisation of XbaI-, S1- and I-CeuI-digested DNA. ESBL enzymes could not be located on plasmids in 17/356 isolates (4.8%). These 17 isolates, from different countries and years, were ascribed to phylogenetic groups D (9), B2 (6) and B1 (2), and to seven sequence types, with ST38 being the most frequent (7 phylogroup D isolates). Eleven isolates produced CTX-M-15. blaCTX-M-15 genes were associated with ISEcp1. The remaining isolates expressed the CTX-M group 9 beta-lactamases CTX-M-14 (4), CTX-M-9 (1) and CTX-M-51 (1). blaCTX-M probes hybridised with I-CeuI- and/or XbaI-digested DNA, but not with S1-digested DNA, corroborating their chromosomal location. To summarise, only 4.8% of a large collection of ESBL-producing E. coli isolates harboured chromosomal blaCTX-M genes. These isolates were of human origin and belonged predominantly to ST38 and ST131, which possibly indicates the role of these sequence types in this phenomenon. However, heterogeneity among isolates was found, suggesting that their spread is not only due to the dispersion of successful E. coli clones. Descriptors Links Book Title Database Publisher Elsevier B.V. and the International Society of Chemotherapy Data Source Authors Rodriguez,I., Thomas,K., Van Essen,A., Schink,A.K., Day,M., Chattaway,M., Wu,G., Mevius,D., Helmuth,R., Guerra,B., SAFEFOODERA-ESBL consortium Original/Translated Title URL Date of Electronic 20140416 PMCID Editors
Chronic and vaccine-preventable diseases in children and adolescents in Germany: results of the KiGGS study: first follow up (KiGGS wave 1)	2014	Abteilung fur Epidemiologie und Gesundheitsmonitoring, Robert Koch-Institut, General-Pape-Strasse 62-66, 12101, Berlin, Deutschland, neuhauserh@rki.de.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Periodical, Abbrev. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Pub Date Free Form Jul Volume 57 Issue 7 Start Page 779 Other Pages 788 Notes LR: 20160707; JID: 101181368; ppublish Place of Publication Germany ISSN/ISBN 1437-1588; 1436-9990 Accession Number PMID: 24950827 Language ger SubFile English Abstract; Journal Article; IM DOI 10.1007/s00103-014-1976-6 [doi] Output Language Unknown(0) PMID 24950827 Abstract The German Health Interview and Examination Survey for Children and Adolescents (KiGGS) 2003-2006 is the first nationwide comprehensive study on the health of children and adolescents living in Germany. The KiGGS first interview follow-up is a telephone interview study that collected, among other things, data on a number of chronic and vaccine-preventable diseases in 2009-2012 and is a combined cross-sectional and longitudinal study based on a population registry sample from the 167 KiGGS study points. The analysis is based on 12,368 respondents (7913 KiGGS follow-up participants aged 7-17 years, response 72 % and 4455 newly recruited 0- to 6-year-olds, response 42 %). Based on parent reports the lifetime prevalence of both chickenpox and pertussis has decreased in the population targeted by recently changed vaccination recommendations. For measles the prevalence remained unsatisfactorily high in each investigated age group. Of the children and adolescents aged 0-17 years 16 % (95 % confidence interval CI 15.2-17.0 %) had a long-standing chronic health condition according to the parents. Of these, however, only one in five was affected in their routine daily activities. The lifetime prevalence in 7- to 17-year-olds was 1.2 % (0.9-1.6) for epilepsy (0.4 % for the past 12 months), 5.0 % (4.4-5.7) for migraine, 0.2 % (0.1-0.3) for diabetes and in 0 to 6-year-olds 2.0 % (1.5-2.6) for heart conditions and 3.1 % (2.5-3.8) for febrile seizures with a -prevalence in 0 to 2-year-olds which are most affected of 1.0 % (0.6-1.6) in the past 12 months. The vast majority of children and adolescents in Germany are in good or very good health as suggested by other results reported in this issue; however, chronic conditions are not rare and need continuous monitoring. These results confirm that implementation of the vaccination recommendations of the German Standing Committee on Vaccination (STIKO) can lead to effective prevention of infectious diseases in Germany. Descriptors Links Book Title Database Publisher Data Source Authors Neuhauser,H., Poethko-Muller,C., KiGGS Study Group Original/Translated Title Chronische Erkrankungen und impfpraventable Infektionserkrankungen bei Kindern und Jugendlichen in Deutschland : Ergebnisse der KiGGS-Studie - Erste Folgebefragung (KiGGS Welle 1) URL Date of Electronic PMCID Editors
Chronic Exposure to Water-Pipe Smoke Induces Alveolar Enlargement, DNA Damage and Impairment of Lung Function	2016		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Cell Physiol Biochem Periodical, Abbrev. Cell.Physiol.Biochem. Pub Date Free Form Volume 38 Issue 3 Start Page 982 Other Pages 92 Notes ID: 26938718 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract BACKGROUND/AIM: Epidemiological evidence indicates that water-pipe smoking (WPS) adversely affects the respiratory system. However, the mechanisms underlying its effects are not well understood. Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. METHODS: Mice were nose-only exposed to mainstream WPS (30 min/day; 5 days/week for 6 consecutive months). Control mice were exposed using the same protocol to atmospheric air only. At the end of the exposure period, several respiratory parameters were assessed. RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. Interestingly, we found dilated alveolar spaces and alveolar ducts with damaged interalveolar septae, and impairment of lung function following WPS exposure. CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. Our findings provide novel mechanistic elucidation for the long-term effects of WPS on the respiratory system. Descriptors Links http://dx.doi.org/10.1159/000443050 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Nemmar,Abderrahim, Al-Salam, Suhail, Yuvaraju,Priya, Beegam,Sumaya, Yasin,Javed, Ali,Badreldin H. Original/Translated Title URL Date of Electronic PMCID Editors
Chronic lead poisoning in the course of ten years	2001	MachartovÃ¡, V., Klinika Pracovniho Lekarstvi, 305 99 PlzeÅˆ, Czech Republic	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pracovni Lekarstvi Periodical, Abbrev. Prac.Lek. Pub Date Free Form 2001/ Volume 53 Issue 4 Start Page 170 Other Pages 172 Notes Place of Publication ISSN/ISBN 0032-6291 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract The author followed up for 10 years a family with non-occupational lead intoxication. The sources of lead were water pipes and acid water from their own well. The family was exposed in 1951-1991. Four members of the family were examined. Two members of the family are still in our care. In the latter after mobilizations deposited lead is released from the organism, the toxicological lead levels at rest are within physiological limits. Lead mobilization from the organism is problematical with regard to the reduced renal function which is progressing. Even 10 years after terminated exposure lead is still deposited in the organism. Descriptors aminolevulinic acid, coproporphyrin, edetate calcium disodium, lead, well water, article, case report, chronic kidney failure, follow up, human, lead blood level, lead poisoning, urine level, chelintox Links Book Title ChronickÃ¡ otrava olovem v prÅ¯bÄ›hu 10 let Database Embase Publisher Data Source Embase Authors MachartovÃ¡,V. Original/Translated Title URL Date of Electronic PMCID Editors
Chronic obstructive pulmonary disease prevalence in Lebanon: a cross-sectional descriptive study	2011		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clin Epidemiol Periodical, Abbrev. Pub Date Free Form Volume 3 Issue Start Page 315 Other Pages 23 Notes ID: 22253549 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD) continues to increase worldwide. The objective of this study was to determine the prevalence of COPD in Lebanese adults. METHODS: A cross-sectional study was carried out using a multistage cluster sample from all over Lebanon. Residents aged 40 years and over were enrolled. Subjects underwent baseline spirometry and answered a questionnaire. After an albuterol + ipratropium bromide bronchodilator, a posttest was performed. RESULTS: Of 2201 individuals, only 33.3% had never smoked. The prevalence of COPD by the Global Initiative for Chronic Obstructive Lung Disease definition, was 9.7% (95% confidence interval CI]: 8.5%-10.9%). According to the 5% lower limit of normal definition of COPD, the prevalence was 12.5% (95% CI: 11.2%-13.9%). A total of 20.2% were already diagnosed by a physician. No differences in symptoms across stages of COPD were found, but there was a significant trend for a higher number of visits to the emergency room and to the doctor (P < 0.001), and a higher number of hospitalizations (P < 0.001). Older individuals had an increased risk of COPD (adjusted odds ratio OR(a)] = 1.05); so did "ever" cigarette smokers (OR(a) = 4.88) and water-pipe smokers (OR(a) = 2.53). CONCLUSION: This is the first epidemiological study in Lebanon that determined COPD prevalence and the link with water-pipe smoking. Descriptors Links http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257901/?tool=pubmed; http://dx.doi.org/10.2147/CLEP.S26350 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Waked,Mirna, Khayat,George, Salameh,Pascale Original/Translated Title URL Date of Electronic PMCID Editors
Chronic subclinical lead poisoning from the use of a water pipe; report of a case.	1950	Scovel, F.G.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Chinese medical journal Periodical, Abbrev. Chin.Med.J. Pub Date Free Form / Volume 68 Issue 12-Nov Start Page 363 Other Pages 364 Notes Place of Publication ISSN/ISBN Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Descriptors lead, article Links Book Title Database MEDLINE Publisher Data Source Embase Authors Scovel,F. G. Original/Translated Title URL Date of Electronic PMCID Editors
Chronological Review on Scientific Findings of Bonghan System and Primo Vascular System	2016	Department of Chemical Engineering, University of Louisville, Louisville, KY, 40292, USA. kyung.kang@louisville.edu.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Advances in Experimental Medicine and Biology Periodical, Abbrev. Adv.Exp.Med.Biol. Pub Date Free Form Volume 923 Issue Start Page 301 Other Pages 309 Notes JID: 0121103; OTO: NOTNLM; ppublish Place of Publication United States ISSN/ISBN 0065-2598; 0065-2598 Accession Number PMID: 27526157 Language eng SubFile Journal Article; IM DOI 10.1007/978-3-319-38810-6_40 [doi] Output Language Unknown(0) PMID 27526157 Abstract In 1962, Bonghan Kim in North Korea published a report on a new vascular system in mammals, which he claimed as the acupuncture meridian. He soon named it the Bonghan System. Between 1962 and 1965, he published five reports, with detailed descriptions on the system. Kim also described the self-regenerating nature of a unique cell type Sanals in the system and these cells are now confirmed to be a type of stem cells. According to his findings, the system appears to have vital roles in maintaining mammalian lives. Kim disappeared in around 1965 and the research on this system also completely stopped. In 2002, Kwang-Sup Soh reported re-discovery of the system and, since then, his team has been leading the research on the system. The Soh team has confirmed many of Kim's findings to be valid, although so many of Kim's results are still to be verified. In 2010, the system was renamed the Primo Vascular System (PVS). Soh and researchers trained by Soh have also been reporting new scientific facts on the system. The PVS exists throughout the entire body, including inside the blood and lymphatic vessels. Recent reports revealed more evidence for it to be the acupuncture meridian, where some acupuncture therapies are applied for the blood pressure control. Thus, the PVS is expected to have roles in the oxygen transport in tissues. Many study results also suggest that the PVS may have roles in body homeostasis and regeneration. This article chronologically reviews Kim's scientific findings on the Bonghan System, which were verified by the PVS scientists (after 2000), and also the new findings reported by the PVS scientists. Descriptors Links Book Title Database Publisher Data Source Authors Kang,K.A. Original/Translated Title URL Date of Electronic PMCID Editors
Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)	2011	Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO Periodical, Abbrev. Ann.Oncol. Pub Date Free Form Jun Volume 22 Issue 6 Start Page 1420 Other Pages 1426 Notes LR: 20150813; GR: 5R01-CA098870/CA/NCI NIH HHS/United States; GR: CA098889/CA/NCI NIH HHS/United States; GR: CA108370/CA/NCI NIH HHS/United States; GR: CA109767/CA/NCI NIH HHS/United States; GR: CA59706/CA/NCI NIH HHS/United States; GR: CA89726/CA/NCI NIH Place of Publication England ISSN/ISBN 1569-8041; 0923-7534 Accession Number PMID: 21245160 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; IM DOI 10.1093/annonc/mdq613 [doi] Output Language Unknown(0) PMID 21245160 Abstract BACKGROUND: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. MATERIALS AND METHODS: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11,338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. RESULTS: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipe-only smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for >/= 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). CONCLUSION: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use. Descriptors Links Book Title Database Publisher Data Source Authors Bertuccio,P., La Vecchia,C., Silverman,D.T., Petersen,G.M., Bracci,P.M., Negri,E., Li,D., Risch,H.A., Olson,S.H., Gallinger,S., Miller,A.B., Bueno-de-Mesquita,H.B., Talamini,R., Polesel,J., Ghadirian,P., Baghurst,P.A., Zatonski,W., Fontham,E.T., Bamlet,W.R., Holly,E.A., Lucenteforte,E., Hassan,M., Yu,H., Kurtz,R.C., Cotterchio,M., Su,J., Maisonneuve,P., Duell,E.J., Bosetti,C., Boffetta,P. Original/Translated Title URL Date of Electronic 20110118 PMCID PMC3139985 Editors
Cigar smoking among U.S. students: reported use after adding brands to survey items	2014	Office of Science, Center for Tobacco Products, Food and Drug Administration, Rockville, Maryland. Electronic address: catherine.corey@fda.hhs.gov.; Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Ge	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Preventive Medicine Periodical, Abbrev. Am.J.Prev.Med. Pub Date Free Form Aug Volume 47 Issue 2 Suppl 1 Start Page S28 Other Pages 35 Notes LR: 20151026; CI: Published by Elsevier Inc.; GR: CC999999/Intramural CDC HHS/United States; JID: 8704773; HHSPA709984; OID: NLM: HHSPA709984; OID: NLM: PMC4521384; 2013/11/28 [received]; 2014/05/01 [revised]; 2014/05/02 [accepted]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-2607; 0749-3797 Accession Number PMID: 25044193 Language eng SubFile Journal Article; IM DOI 10.1016/j.amepre.2014.05.004 [doi] Output Language Unknown(0) PMID 25044193 Abstract BACKGROUND: Among U.S. youth overall, cigars are the most commonly used tobacco product after cigarettes. However, youth who identify their products by brand names, not general terms like "cigar," may underreport use. PURPOSE: To examine changes in reported cigar (cigar, cigarillo, or little cigar) smoking among students following inclusion of cigar brand examples on the National Youth Tobacco Survey (NYTS). METHODS: Data from the 2011 and 2012 NYTS and National Survey on Drug Use and Health (NSDUH) were analyzed in 2013 to estimate ever and current cigar smoking, overall and by race/ethnicity. The 2012 NYTS included cigar brand examples (Black and Mild, Swisher Sweets, Dutch Masters, White Owl, Phillies Blunt) in the survey instructions and ever use question, but the 2011 NYTS and 2011 and 2012 NSDUH did not. RESULTS: NYTS ever cigar smoking was higher in 2012 (27.8%) than 2011 (19.5%) among black students overall. Current cigar smoking was 60%-70% higher among black females and students aged >/= 17 years, in 2012 than 2011. For black females, current cigar smoking (11.5%) was two times greater than that of white females (4.3%) in 2012, whereas the prevalence among these subgroups was comparable in 2011. Similar changes were not observed among these subgroups in the 2011-2012 NSDUH. CONCLUSIONS: This study highlights the high burden of cigar use among U.S. youth and suggests that NYTS ascertainment of cigar smoking may have improved by including brands. Disparities in cigar smoking need to be addressed to prevent and reduce all youth tobacco use. Descriptors Links Book Title Database Publisher Data Source Authors Corey,C.G., Dube,S.R., Ambrose,B.K., King,B.A., Apelberg,B.J., Husten,C.G. Original/Translated Title URL Date of Electronic PMCID PMC4521384 Editors

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