WTS database

Title Sort descending	Pub Year	Author	SearchLink
Biogeochemical cycling in coniferous ecosystems on different aged marine terraces in Coastal Oregon	1997	Bockheim, J.G., Dep. of Soil Science, Univ. of Wisconsin, Madison, WI 53706-1299, United States	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of environmental quality Periodical, Abbrev. J.Environ.Qual. Pub Date Free Form 1997/01 Volume 26 Issue 1 Start Page 292 Other Pages 301 Notes Place of Publication ISSN/ISBN 0047-2425 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Biogeochemical cycling was studied in Sitka spruce [Picea sitchensis (Bong.) Carr.] and western hemlock-Douglas-fir [Tsuga heterophylla (Raf.) Sarg.-Pseudotsuga menziesii (Mirbel) Franco] ecosystems on a chronosequence of five uplifted marine terraces in coastal Oregon. The terraces occur 0.25 to 8.6 km from the Pacific Ocean and range from 80 to ~ 500 kyr in age. The soils are highly weathered and include Inceptisols on the youngest terrace and Spodosols with clay-enriched horizons and Ultisols on the older terraces. Bulk precipitation, throughfall, and soil solutions (four depths) were collected monthly from November 1992 through April 1993. The solutions were analyzed for pH, dissolved cartons (Na, Mg, Ca, K, Fe, Al, and Si), anions (Cl, SO4, HCO3, NO3, and PO4), and organic C. Cations (Î¼mol, L-1) in all solutions were ranked: Na > Mg > Ca â‰¤ K > H; anions were ranked: Cl > SO4 > NO3 >> HCO3. The Na/Cl ratio in all solutions was comparable to that of seawater. The mean sums of cations and anions in all solutions declined sharply with distance from the coast. Throughfall enrichment of all ions suggests that aerosol impaction of sea salts is a dominant process within the coastal fogbelt of Oregon. In that the soils have low inherent fertility, the trees appear to obtain Ca, Mg, K, and S primarily from atmospheric sources. These nutrients are utilized by abundant fine roots in the forest floor and upper 5 to 20 cm of mineral soil. Net cation loss is less than in other areas of the Pacific Northwest and is controlled by organic anions rather than the bicarbonate anion. Descriptors anion, carbon, cation, article, clay, ecosystem, seashore, soil, tree, United States Links Book Title Database Embase Publisher Data Source Embase Authors Bockheim,J. G., Langley-Turnbaugh,S. Original/Translated Title URL Date of Electronic PMCID Editors
Biologics in spine arthrodesis	2015	Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of spinal disorders & techniques Periodical, Abbrev. J.Spinal.Disord.Tech. Pub Date Free Form Jun Volume 28 Issue 5 Start Page 163 Other Pages 170 Notes JID: 101140323; 0 (Bone Morphogenetic Protein 2); 0 (Recombinant Proteins); ppublish Place of Publication United States ISSN/ISBN 1539-2465; 1536-0652 Accession Number PMID: 25978141 Language eng SubFile Journal Article; Review; IM DOI 10.1097/BSD.0000000000000281 [doi] Output Language Unknown(0) PMID 25978141 Abstract Spine fusion is a tool used in the treatment of spine trauma, tumors, and degenerative disorders. Poor outcomes related to failure of fusion, however, have directed the interests of practitioners and scientists to spinal biologics that may impact fusion at the cellular level. These biologics are used to achieve successful arthrodesis in the treatment of symptomatic deformity or instability. Historically, autologous bone grafting, including iliac crest bong graft harvesting, had represented the gold standard in spinal arthrodesis. However, due to concerns over potential harvest site complications, supply limitations, and associated morbidity, surgeons have turned to other bone graft options known for their osteogenic, osteoinductive, and/or osteoconductive properties. Current bone graft selection includes autograft, allograft, demineralized bone matrix, ceramics, mesenchymal stem cells, and recombinant human bone morphogenetic protein. Each pose their respective advantages and disadvantages and are the focus of ongoing research investigating the safety and efficacy of their use in the setting of spinal fusion. Rh-BMP2 has been plagued by issues of widespread off-label use, controversial indications, and a wide range of adverse effects. The risks associated with high concentrations of exogenous growth factors have led to investigational efforts into nanotechnology and its application in spinal arthrodesis through the binding of endogenous growth factors. Bone graft selection remains critical to successful fusion and favorable patient outcomes, and orthopaedic surgeons must be educated on the utility and limitations of various biologics in the setting of spine arthrodesis. Descriptors Links Book Title Database Publisher Data Source Authors Kannan,A., Dodwad,S.N., Hsu,W.K. Original/Translated Title URL Date of Electronic PMCID Editors
Biology and fishery of the lobster Panulirus gracilis in Playa Lagarto, Guanacaste, Costa Rica	2011	helvenn@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Revista de biologia tropical Periodical, Abbrev. Rev.Biol.Trop. Pub Date Free Form Jun Volume 59 Issue 2 Start Page 619 Other Pages 633 Notes JID: 0404267; ppublish Place of Publication Costa Rica ISSN/ISBN 0034-7744; 0034-7744 Accession Number PMID: 21721230 Language spa SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 21721230 Abstract Panulirus gracilis is a high valuable lobster species with considerable captures along the tropical Pacific coast. In this study, I present some biological and fishery parameters described after a sample of 843 lobsters, landed in Playa Lagarto from November 2007 to October 2008. From landing records, a total of 74.9% of lobsters were below the minimum legal catch size (80 mm CL). Carapace lengths were in the range of 42.8 and 143.6 mm for males and 115 and 35.8 mm for females. The size structure showed a wide overlapping of population segments, and a trend to increase with depth, where lung diving and "hooka" diving operations take place. Sex ratio was 1.36 M:H. The relationship between weight and LC revealed that females are heavier than males of the same size, and this difference was significant (p Descriptors Links Book Title Database Publisher Data Source Authors Madrigal,H.N. Original/Translated Title Biologia pesquera de la langosta Panulirus gracilis en Playa Lagarto, Guanacaste, Costa Rica URL Date of Electronic PMCID Editors
Biomarkers in neuroendocrine tumors	2013	Division of Hematology Oncology, Tufts Cancer Center. Boston, MA 02111, USA. dr.marvin.duque@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full JOP : Journal of the pancreas Periodical, Abbrev. JOP Pub Date Free Form 10-Jul Volume 14 Issue 4 Start Page 372 Other Pages 376 Notes LR: 20151119; JID: 101091810; 0 (Biomarkers, Tumor); 0 (Chromogranin A); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.10.1 (Receptor, IGF Type 1); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); 2013/06/ Place of Publication Italy ISSN/ISBN 1590-8577; 1590-8577 Accession Number PMID: 23846930 Language eng SubFile Journal Article; IM DOI 10.6092/1590-8577/1692 [doi] Output Language Unknown(0) PMID 23846930 Abstract Neuroendocrine tumors are a heterogeneous group of tumors with cells of neuroendocrine differentiation that arise from diverse anatomic sites with varying morphologic and clinical features. Since the natural history and prognosis varies widely between individual neuroendocrine tumor types, there is a critical need to identify accurate prognostic and predictive biomarkers and markers predictive of therapeutic efficacy. To date, plasma chromogranin-A levels have generally been accepted as the most useful biomarker, despite the fact that there are substantial concerns in sensitivity and discrepancies in measurement techniques. As a consequence, considerable attention has been focused upon the development of novel biomarkers that can be utilized with more clinical efficacy than chromogranin-A. In addition to amplifying the diagnostic/prognostic landscape, the need to calibrate the efficacy of biological targeted therapy has further accelerated the development of molecular biomarkers. At the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, Chou et al. (Abstract #e15151) presented data that chromogranin A levels can be monitored during treatment to predict clinical outcome. Modlin et al. (Abstract #4137), demonstrated a promising novel biomarker, serum multi-transcript molecular signature. Grande et al. (Abstract #4140), Heetfield et al. (Abstract #e15071) and Casanovas et al. (Abstract #4139) described sVEGFR2, p-mTOR and IGF1R as molecular markers with potential for use in targeted therapy trials. The authors review and summarize these abstracts in this article. Descriptors Links Book Title Database Publisher Data Source Authors Duque,M., Modlin,I.M., Gupta,A., Saif,M.W. Original/Translated Title URL Date of Electronic 20130710 PMCID Editors
Biomarkers in pancreatic neuroendocrine tumors	2014	Oncology Unit, Third Department of Medicine, Sotiria General Hospital. Athens, Greece. mtheochari@gmail.com.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full JOP : Journal of the pancreas Periodical, Abbrev. JOP Pub Date Free Form 10-Mar Volume 15 Issue 2 Start Page 138 Other Pages 139 Notes LR: 20151119; JID: 101091810; 0 (Biomarkers, Tumor); 0 (MIRN27 microRNA, human); 0 (MicroRNAs); 0 (Smad4 Protein); 2014/02/06 [received]; 2014/02/07 [accepted]; epublish Place of Publication Italy ISSN/ISBN 1590-8577; 1590-8577 Accession Number PMID: 24618438 Language eng SubFile Congresses; IM DOI 10.6092/1590-8577/2321 [doi] Output Language Unknown(0) PMID 24618438 Abstract The aim of biomarkers is to identify patients most likely to benefit from a therapeutic strategy. Pancreatic neuroendocrine tumors are rare neoplasms that arise in the endocrine tissues of the pancreas. Pancreatic neuroendocrine tumors represent 3% of primary pancreatic neoplasms and their incidence has risen. The SMAD4 gene is located on chromosome 18q and someday the SMAD4 gene status may be useful for prognostic stratification and therapeutic decision. The cells respond to environmental signals by modulating the expressions of genes contained within the nucleus, when genes are activated are transcribed to generate messenger RNA (mRNA). The examination of multiple expressed genes and proteins provides more useful information for prognostication of individual tumors. Here we summarize and discuss findings presented at the 2014 ASCO Gastrointestinal Cancers Symposium. Anna Karpathakis et al. (Abstract #212) reported data about the role of DNA methylation in gastrointestinal neuroendocrine tumors. Christina Lynn Roland et al. (Abstract #250) looked the impact Of SMAD4 on oncologic outcomes. Bong Kynn Kang et al. (Abstract #251) investigated prognostic biomarker using microRNA array technology. Descriptors Links Book Title Database Publisher Data Source Authors Theochari,M.S., Syrigos,K.N., Saif,M.W. Original/Translated Title URL Date of Electronic 20140310 PMCID Editors
Biomarkers of secondhand smoke exposure in automobiles	2014	Department of Psychiatry, University of California, , Los Angeles, California, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Jan Volume 23 Issue 1 Start Page 51 Other Pages 57 Notes LR: 20151119; GR: DA12393/DA/NIDA NIH HHS/United States; GR: P30 DA012393/DA/NIDA NIH HHS/United States; GR: R25 CA 113710/CA/NCI NIH HHS/United States; GR: R25 CA113710/CA/NCI NIH HHS/United States; GR: UL1 RR024131/RR/NCRR NIH HHS/United States; JID: 92 Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 23349229 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1136/tobaccocontrol-2012-050724 [doi] Output Language Unknown(0) PMID 23349229 Abstract OBJECTIVES: The objectives of this study were: (1) to characterise the exposure of non-smokers exposed to secondhand smoke (SHS) in a vehicle using biomarkers, (2) to describe the time course of the biomarkers over 24 h, and (3) to examine the relationship between tobacco biomarkers and airborne concentrations of SHS markers. METHODS: Eight non-smokers were individually exposed to SHS in cars with fully open front windows and closed back windows over an hour from a smoker who smoked three cigarettes at 20 min intervals. The non-smokers sat in the back seat on the passenger side, while the smoker sat in the driver's seat. Plasma cotinine and urine cotinine, 3-hydroxycotinine (3HC) and 4-(methylnitrosoamino)-(3-pyridyl)-1-butanol (NNAL) were compared in samples taken at baseline (BL) and several time-points after exposure. Nicotine, particulate matter (PM2.5) and carbon monoxide (CO) were measured inside and outside the vehicle and ventilation rates in the cars were measured. RESULTS: Average plasma cotinine and the molar sum of urine cotinine and 3HC (COT+3HC) increased four-fold, urine cotinine increased six-fold and urine NNAL increased approximately 27 times compared to BL biomarker levels. Plasma cotinine, urine COT+3HC and NNAL peaked at 4-8 h post-exposure while urine cotinine peaked within 4 h. Plasma cotinine was significantly correlated to PM2.5 (Spearman correlation rs=0.94) and CO (rs=0.76) but not to air nicotine. The correlations between urine biomarkers, cotinine, COT+3HC and NNAL, and air nicotine, PM2.5 and CO were moderate but non-significant (rs range = 0.31-0.60). CONCLUSIONS: Brief SHS exposure in cars resulted in substantial increases in levels of tobacco biomarkers in non-smokers. For optimal characterisation of SHS exposure, tobacco biomarkers should be measured within 4-8 h post-exposure. Additional studies are needed to better describe the relationship between tobacco biomarkers and environmental markers of SHS. Descriptors Links Book Title Database Publisher Data Source Authors Jones,I.A., St Helen,G., Meyers,M.J., Dempsey,D.A., Havel,C., Jacob,P.,3rd, Northcross,A., Hammond,S.K., Benowitz,N.L. Original/Translated Title URL Date of Electronic 20130124 PMCID PMC3670969 Editors
Biomarkers of secondhand smoke exposure in waterpipe tobacco venue employees in Istanbul, Moscow, and Cairo	2017		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine and Tobacco Research Periodical, Abbrev. Pub Date Free Form Volume 20 Issue 4 Start Page 482 Other Pages 491 Notes Place of Publication ISSN/ISBN Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Descriptors Links Book Title Database Publisher Oxford University Press US Data Source google Authors Moon, Katherine A, Rule, Ana M, Magid, Hoda S, Ferguson, Jacqueline M, Susan, Jolie, Sun, Zhuolu, Torrey, Christine, Abubaker, Salahaddin, Levshin, Vladimir, Ã‡arkoÄŸlu, AslÄ± Original/Translated Title URL Date of Electronic PMCID Editors
Biomedical risk assessment as an aid for smoking cessation	2012	Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. raphael.bize@chuv.ch.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 12-Dec Volume 12 Issue Start Page CD004705 Other Pages Notes LR: 20131121; JID: 100909747; 7U1EE4V452 (Carbon Monoxide); epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 23235615 Language eng SubFile Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM DOI 10.1002/14651858.CD004705.pub4 [doi] Output Language Unknown(0) PMID 23235615 Abstract BACKGROUND: A possible strategy for increasing smoking cessation rates could be to provide smokers who have contact with healthcare systems with feedback on the biomedical or potential future effects of smoking, e.g. measurement of exhaled carbon monoxide (CO), lung function, or genetic susceptibility to lung cancer. OBJECTIVES: To determine the efficacy of biomedical risk assessment provided in addition to various levels of counselling, as a contributing aid to smoking cessation. SEARCH METHODS: For the most recent update, we searched the Cochrane Collaboration Tobacco Addiction Group Specialized Register in July 2012 for studies added since the last update in 2009. SELECTION CRITERIA: Inclusion criteria were: a randomized controlled trial design; subjects participating in smoking cessation interventions; interventions based on a biomedical test to increase motivation to quit; control groups receiving all other components of intervention; an outcome of smoking cessation rate at least six months after the start of the intervention. DATA COLLECTION AND ANALYSIS: Two assessors independently conducted data extraction on each paper, with disagreements resolved by consensus. Results were expressed as a relative risk (RR) for smoking cessation with 95% confidence intervals (CI). Where appropriate, a pooled effect was estimated using a Mantel-Haenszel fixed-effect method. MAIN RESULTS: We included 15 trials using a variety of biomedical tests. Two pairs of trials had sufficiently similar recruitment, setting and interventions to calculate a pooled effect; there was no evidence that carbon monoxide (CO) measurement in primary care (RR 1.06, 95% CI 0.85 to 1.32) or spirometry in primary care (RR 1.18, 95% CI 0.77 to 1.81) increased cessation rates. We did not pool the other 11 trials due to the presence of substantial clinical heterogeneity. Of the remaining 11 trials, two trials detected statistically significant benefits: one trial in primary care detected a significant benefit of lung age feedback after spirometry (RR 2.12, 95% CI 1.24 to 3.62) and one trial that used ultrasonography of carotid and femoral arteries and photographs of plaques detected a benefit (RR 2.77, 95% CI 1.04 to 7.41) but enrolled a population of light smokers and was judged to be at unclear risk of bias in two domains. Nine further trials did not detect significant effects. One of these tested CO feedback alone and CO combined with genetic susceptibility as two different interventions; none of the three possible comparisons detected significant effects. One trial used CO measurement, one used ultrasonography of carotid arteries and two tested for genetic markers. The four remaining trials used a combination of CO and spirometry feedback in different settings. AUTHORS' CONCLUSIONS: There is little evidence about the effects of most types of biomedical tests for risk assessment on smoking cessation. Of the fifteen included studies, only two detected a significant effect of the intervention. Spirometry combined with an interpretation of the results in terms of 'lung age' had a significant effect in a single good quality trial but the evidence is not optimal. A trial of carotid plaque screening using ultrasound also detected a significant effect, but a second larger study of a similar feedback mechanism did not detect evidence of an effect. Only two pairs of studies were similar enough in terms of recruitment, setting, and intervention to allow meta-analyses; neither of these found evidence of an effect. Mixed quality evidence does not support the hypothesis that other types of biomedical risk assessment increase smoking cessation in comparison to standard treatment. There is insufficient evidence with which to evaluate the hypothesis that multiple types of assessment are more effective than single forms of assessment. Descriptors Links Book Title Database Publisher Data Source Authors Bize,R., Burnand,B., Mueller,Y., Rege-Walther,M., Camain,J.Y., Cornuz,J. Original/Translated Title URL Date of Electronic 20121212 PMCID Editors
Biomedical risk assessment as an aid for smoking cessation	2009	Department of Ambulatory Care and Community Medicine & Clinical Epidemiology Centre, University of Lausanne, Bugnon 44, Lausanne, Switzerland, CH-1011. raphael.bize@hospvd.ch	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 15-Apr Volume (2):CD004705. doi Issue 2 Start Page CD004705 Other Pages Notes LR: 20131121; JID: 100909747; 7U1EE4V452 (Carbon Monoxide); UIN: Cochrane Database Syst Rev. 2012;12:CD004705. PMID: 23235615; RF: 78; epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 19370604 Language eng SubFile Journal Article; Meta-Analysis; Review; IM DOI 10.1002/14651858.CD004705.pub3 [doi] Output Language Unknown(0) PMID 19370604 Abstract BACKGROUND: A possible strategy for increasing smoking cessation rates could be to provide smokers who have contact with healthcare systems with feedback on the biomedical or potential future effects of smoking, e.g. measurement of exhaled carbon monoxide (CO), lung function, or genetic susceptibility to lung cancer. OBJECTIVES: To determine the efficacy of biomedical risk assessment provided in addition to various levels of counselling, as a contributing aid to smoking cessation. SEARCH STRATEGY: We systematically searched the Cochrane Collaboration Tobacco Addiction Group Specialized Register, Cochrane Central Register of Controlled Trials 2008 Issue 4, MEDLINE (1966 to January 2009), and EMBASE (1980 to January 2009). We combined methodological terms with terms related to smoking cessation counselling and biomedical measurements. SELECTION CRITERIA: Inclusion criteria were: a randomized controlled trial design; subjects participating in smoking cessation interventions; interventions based on a biomedical test to increase motivation to quit; control groups receiving all other components of intervention; an outcome of smoking cessation rate at least six months after the start of the intervention. DATA COLLECTION AND ANALYSIS: Two assessors independently conducted data extraction on each paper, with disagreements resolved by consensus. Results were expressed as a relative risk (RR) for smoking cessation with 95% confidence intervals (CI). Where appropriate a pooled effect was estimated using a Mantel-Haenszel fixed effect method. MAIN RESULTS: We included eleven trials using a variety of biomedical tests. Two pairs of trials had sufficiently similar recruitment, setting and interventions to calculate a pooled effect; there was no evidence that CO measurement in primary care (RR 1.06, 95% CI 0.85 to 1.32) or spirometry in primary care (RR 1.18, 95% CI 0.77 to 1.81) increased cessation rates. We did not pool the other seven trials. One trial in primary care detected a significant benefit of lung age feedback after spirometry (RR 2.12; 95% CI 1.24 to 3.62). One trial that used ultrasonography of carotid and femoral arteries and photographs of plaques detected a benefit (RR 2.77; 95% CI 1.04 to 7.41) but enrolled a population of light smokers. Five trials failed to detect evidence of a significant effect. One of these tested CO feedback alone and CO + genetic susceptibility as two different intervention; none of the three possible comparisons detected significant effects. Three others used a combination of CO and spirometry feedback in different settings, and one tested for a genetic marker. AUTHORS' CONCLUSIONS: There is little evidence about the effects of most types of biomedical tests for risk assessment. Spirometry combined with an interpretation of the results in terms of 'lung age' had a significant effect in a single good quality trial. Mixed quality evidence does not support the hypothesis that other types of biomedical risk assessment increase smoking cessation in comparison to standard treatment. Only two pairs of studies were similar enough in term of recruitment, setting, and intervention to allow meta-analysis. Descriptors Biofeedback, Psychology/methods, Breath Tests, Carbon Monoxide/analysis, Genetic Predisposition to Disease, Humans, Randomized Controlled Trials as Topic, Risk Assessment, Smoking/adverse effects/metabolism, Smoking Cessation/methods/psychology/statistics & numerical data, Spirometry Links Book Title Database Publisher Data Source Authors Bize,R., Burnand,B., Mueller,Y., Rege Walther,M., Cornuz,J. Original/Translated Title URL Date of Electronic 20090415 PMCID Editors
Biomonitoring method for the determination of polycyclic aromatic hydrocarbons in hair by online in-tube solid-phase microextraction coupled with high performance liquid chromatography and fluorescence detection	2015	School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.; School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.; School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan. Electronic addre	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.B, Analytical technologies in the biomedical and life sciences Periodical, Abbrev. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. Pub Date Free Form 1-Sep Volume 1000 Issue Start Page 187 Other Pages 191 Notes CI: Copyright (c) 2015; JID: 101139554; 0 (Polycyclic Hydrocarbons, Aromatic); OTO: NOTNLM; 2015/04/29 [received]; 2015/07/06 [revised]; 2015/07/18 [accepted]; 2015/07/26 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 1873-376X; 1570-0232 Accession Number PMID: 26245363 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.jchromb.2015.07.033 [doi] Output Language Unknown(0) PMID 26245363 Abstract Polycyclic aromatic hydrocarbons (PAHs) are formed from the incomplete combustion or pyrolysis of organic matter during industrial processing and various human activities, but human exposure to PAHs has not yet been elucidated in detail. To assess long-term exposure to PAHs, we developed a simple and sensitive method for measuring PAHs in hair by online in-tube solid-phase microextraction using a CP-Sil 19CB capillary column as an extraction device, followed by high-performance liquid chromatography using a Zorbax Eclipse PAH column and fluorescence detection. Seventeen PAHs could be analyzed simultaneously, with good linearity from 20 to 1000pg/mL each as determined using stable isotope-labeled PAH internal standards. The detection limits of PAHs were 0.5-20.4pg/mL. PAHs in human hair samples were extracted by ultrasonication in 50mM NaOH in methanol, and successfully analyzed without any interference peaks, with good recovery rates above 70% in spiked hair samples. Using this method, we evaluated the suitability of using hair PAHs as biomarkers for long-term exposure. Descriptors Links Book Title Database Publisher Elsevier B.V Data Source Authors Yamamoto,Y., Ishizaki,A., Kataoka,H. Original/Translated Title URL Date of Electronic 20150726 PMCID Editors

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