WTS database

Title Sort ascending	Pub Year	Author	SearchLink
The lifestyle habits and wellbeing of physicians in Bahrain: a cross-sectional study	2015	Arab Medical Center, Amman, Jordan. Saifborgan@yahoo.com.; Department of Family and Community Medicine, Royal College of Surgeons in Ireland- Medical University of Bahrain, P.O. Box 15503, Adliya, Kingdom of Bahrain. gjassim@rcsi-mub.com.; Salmaniya Medic	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 14-Jul Volume 15 Issue Start Page 655 Other Pages 015-1969-x Notes LR: 20150719; JID: 100968562; OID: NLM: PMC4499902; 2014/12/15 [received]; 2015/06/25 [accepted]; 2015/07/14 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 26170021 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1186/s12889-015-1969-x [doi] Output Language Unknown(0) PMID 26170021 Abstract BACKGROUND: Lifestyle habits of physicians are of paramount importance both because they influence the physician's own health and because these habits have been shown to affect patients' care. There is limited information on physician health and lifestyle habits in Bahrain. METHODS: In a cross-sectional study design, an anonymous self-administered questionnaire that assesses wellbeing and lifestyle habits was distributed to a random sample of 175 out of 320 primary health care physicians in Bahrain. Descriptive analyses were performed, and the variables were cross-tabulated using SPSS version 20.0. RESULTS: 152 physicians agreed to participate in the study. Respondents were 67.1% female with a mean age of 45 (SD = 10). The majority were of Bahraini nationality. The most prevalent reported health conditions were hyperlipidaemia (25.5%), hypertension (20.3%), and diabetes (11.0%). Only 29.6% of physicians reported performing >/= 30 min of exercise in a usual week. Of physicians exercising >/= 30 min weekly, only 13% exercised >/= 5 days weekly. 98.0% report never drinking, 1.3% report previously drinking, and 0.7% report drinking less than once weekly. The average body mass index (BMI) was 27.8 (SD = 5), with 39% of physicians being overweight and 33% obese. BMI was directly associated with sleep time (P0.027, r(2) = 0.034), age (P Descriptors Links Book Title Database Publisher Data Source Authors Borgan,S.M., Jassim,G.A., Marhoon,Z.A., Ibrahim,M.H. Original/Translated Title URL Date of Electronic 20150714 PMCID PMC4499902 Editors
The lead content in teeth as a maker of environmental exposure to lead	2002	Kuchenbecker, D., Inst. fur Arbeitsmed./Sozialmedizin, UniversitÃ¤t Leipzig, 04107 Leipzig, Germany	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Arbeitsmedizin Sozialmedizin Umweltmedizin Periodical, Abbrev. Arbeitsmed.Sozialmed.Umweltmed. Pub Date Free Form 2002/ Volume 37 Issue 8 Start Page 388 Other Pages 393 Notes Place of Publication ISSN/ISBN 0944-6052 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Aim of the study: The aim of the study was to investigate whether the lead concentration in teeth is influenced by the lead content of the material of drinking water pipes. Collective and method: The lead contents of 235 permanent teeth extracted from 190 inhabitants of Leipzig aged 16-93 years, some of whom had lived in houses with water pipes containing lead from birth, were determined with a graphite furnace atomic absorption spectrometer. Results: The lead levels in tooth roots were in the range from 0.5 to 31.1 Î¼g/g dry weight (median 7.0 Î¼g/g). Significant differences were found in the lead concentrations in teeth between people living in houses with water pipes containing lead and those in houses without. Furthermore, the lead content depends on the age of the patient. The tooth lead of younger adults (aged 16-40 years) without additional lead exposure was in the range from 0.5 to 4.6 Î¼g/g dry weight (median 2.2 Î¼g/g), the range for the tooth lead of older dental patients (aged 61-93 years) was found to be from 6.6 to 6.8 Î¼g/g dry weight (median 6.7 Î¼g/g). In the case of patients living in houses with water pipes containing lead, the median lead concentrations in teeth were 7.2 Î¼g/g for younger adults and 14.5 Î¼g/g for older adults. Conclusions: Both previous occupational exposure to lead and non-occupational exposure can be detected in teeth many years after the end of exposure. Descriptors drinking water, lead, adolescent, adult, aged, article, atomic absorption spectrometry, environmental exposure, heavy metal poisoning, household, human, lead poisoning, major clinical study, tooth extraction, water contamination Links Book Title Bleigehalt in zÃ¤hnen als marker einer umweltbedingten bleibelastung Database Embase Publisher Data Source Embase Authors Kuchenbecker,D., Schaffernicht,H., Raddatz,M. Original/Translated Title URL Date of Electronic PMCID Editors
The integration of family planning and childhood immunization services in Togo	1994	Population Council, Dokki, Giza, Egypt.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Studies in family planning Periodical, Abbrev. Stud.Fam.Plann. Pub Date Free Form May-Jun Volume 25 Issue 3 Start Page 176 Other Pages 183 Notes LR: 20041117; JID: 7810364; OID: PIP: 096937; OID: POP: 00231327; OTO: PIP; GN: PIP: TJ: STUDIES IN FAMILY PLANNING.; ppublish Place of Publication UNITED STATES ISSN/ISBN 0039-3665; 0039-3665 Accession Number PMID: 7940622 Language eng SubFile Clinical Trial; Journal Article; Randomized Controlled Trial; IM; J DOI Output Language Unknown(0) PMID 7940622 Abstract Improvements in the constellation of services in the African context are largely addressed through attaining better measures of service integration, which can be achieved through improved referral across categories of health programs. The use of an unobtrusive referral message that linked family planning and the Expanded Program of Immunizations (EPI) services was tested in an operations research study in Togo. The introduction of the referral message was accompanied by an 18-percent increase in awareness of available family planning services and an increase in the average monthly number of new family planning clients of 54 percent. These positive results indicate that the use of referral can have a significant and dramatic impact on family planning services in a relatively short time. In Togo, no evidence existed of a negative impact on EPI services, and a majority of the EPI providers reported satisfaction with the effect of the referral message at the close of the study.; PIP: Quality of care is currently construed to mean matching population needs with service provision. Improvements in African services are valued when there is a constellation of multiple services provided in a fixed center. In Togo, a simple intervention was developed to link childhood immunization and family planning services. Before immunizing each child, the service provider would make 3 family planning statements to the child's mother. The statements were salient and easy to remember: "Madame, your child is still young, and you should be concerned about having another pregnancy too soon." "This clinic provides family planning services that can help you delay your next pregnancy." And, "You should visit the family planning services after the immunization today for more information." Clinic staff were trained in a day and a half orientation session. The referral message was evaluated with a quasi-experimental design. Impact was measured in terms of knowledge of family planning methods and availability of family planning in the clinic, intention to use a contraceptive method, and the history of contraceptive use. 16 urban and rural clinics were involved. The sample included 1000 randomly selected women who has just had their children immunized. The pretest was conducted in January, 1992, and the post test was conducted in August, 1992, 6 months after the intervention in the study. Service statistics were also collected from 9 months prior to the intervention until September, 1992. Pretest and post test women were similar demographically. Recall levels were also similar. The results indicated that control group persons did not show any change in their awareness of family service availability in the clinic. The increase in the study group was from 40% to 58%. Differences between awareness in the control and study groups was 8% before the intervention and 22% after. Women desiring a longer birth-spacing period were more likely to be aware of service availability. The mean number of acceptors in the study group increased significantly from 200 to 307; average monthly number of family planning users also increased significantly from 1035 to 1311, which was a significant difference from control group users. Both groups showed significant increases in number of vaccines administered monthly in the study period. Descriptors Child Health Services/organization & administration, Child, Preschool, Family Planning Services/organization & administration/utilization, Health Knowledge, Attitudes, Practice, Humans, Immunization, Interinstitutional Relations, Operations Research, Patient Acceptance of Health Care, Program Evaluation, Referral and Consultation/organization & administration, Retrospective Studies, Time Factors, Togo, Africa, Africa South Of The Sahara, Communication, Communication Programs, Comparative Studies, Data Collection, Delivery Of Health Care, Developing Countries, Family Planning, Family Planning Programs, French Speaking Africa, Health, Health Services, Integrated Programs, Interviews, Knowledge, Organization And Administration, Pre-post Tests, Primary Health Care, Program Activities, Programs, Referral And Consultation, Research Methodology, Research Report, Service Statistics, Studies, Western Africa Links Book Title Database Publisher Data Source Authors Huntington,D., Aplogan,A. Original/Translated Title URL Date of Electronic PMCID Editors
The influence of prices on youth tobacco use in India	2014	Moody's Analytics, West Chester, PA;	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Jan Volume 16 Suppl 1 Issue Start Page S24 Other Pages 9 Notes JID: 9815751; 2013/06/06 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 23743096 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1093/ntr/ntt041 [doi] Output Language Unknown(0) PMID 23743096 Abstract INTRODUCTION: The tobacco epidemic has been rapidly spreading in many of the poorer nations of the world, including India. Although studies assessing the impact of prices on youth smoking in countries such as the United States are abundant, comparable research on Indian youth has been largely unavailable due to lack of data at the national level. This study aims to bridge this disparity in tobacco research. METHODS: We used data from the Global Youth Tobacco Survey, a national survey among 73,356 youth of age 13-15 years in India, to estimate the price elasticity of tobacco use among Indian youth for three tobacco products: cigarettes, bidi, and gutka. RESULTS: Higher prices can be an effective deterrent to youth tobacco use, irrespective of the form of tobacco. Among the products considered, bidis have the highest price elasticity of participation (-2.70), followed by gutka (0.58) and cigarettes (-0.40). In gender-specific analyses, girls have significantly higher participation price elasticities than boys. CONCLUSION: The results of this study indicate that fiscal measures to increase the price of tobacco products would be effective in curbing the tobacco epidemic in India. Descriptors Links Book Title Database Publisher Data Source Authors Joseph,R.A., Chaloupka,F.J. Original/Translated Title URL Date of Electronic 20130606 PMCID Editors
The influence of menthol, e-cigarettes and other tobacco products on young adults' self-reported changes in past year smoking	2016	Center for Tobacco Studies, Rutgers School of Public Health, New Brunswick, New Jersey, USA Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.; The Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundatio	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Sep Volume 25 Issue 5 Start Page 571 Other Pages 574 Notes LR: 20160822; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/; GR: R01 CA149705/CA/NCI NIH HHS/United Stat Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 26243809 Language eng SubFile Journal Article; IM DOI 10.1136/tobaccocontrol-2015-052325 [doi] Output Language Unknown(0) PMID 26243809 Abstract OBJECTIVE: Progression to regular smoking often occurs during young adulthood. This study examines self-reported changes in past year smoking among young adults and the potential influence of tobacco products on these trajectories. METHODS: Respondents to the 2011 National Young Adult Health Survey who smoked 100 cigarettes in their lifetime (n=909) described smoking behaviour at the time of the survey and 1 year prior. Cigarette smoking trajectories were categorised as: no change, quit, decreased smoking or increased smoking. Participants were also asked about current use of menthol cigarettes and other tobacco products (ie, cigars, smokeless tobacco, hookah) and ever use of e-cigarettes. RESULTS: Most young adults (73.1%) reported stable cigarette smoking behaviours, while 8.2% reported having quit, 5.8% reported that they smoke on fewer days, 5% progressed from someday to daily smoking and 8% increased from not at all to current smoking. The youngest smokers (18-20) had significantly higher odds (adjusted OR (AOR) =2.6) of increasing cigarette use over the past year compared to those aged 30-34, as did blacks versus whites (AOR=2.35). Menthol cigarette use nearly doubled (AOR=1.87) the odds of increased smoking behaviour. E-cigarette and other tobacco product (OTP) use were not associated with increasing smoking but OTP use was negatively associated with remaining quit from cigarettes. CONCLUSIONS: Young adulthood is a critical period for smoking interventions, particularly among those most vulnerable to increasing smoking behaviours (ie, black and younger young adults). Policy efforts to restrict menthol cigarettes may reduce young adult smoking progression. Descriptors Links Book Title Database Publisher Data Source Authors Delnevo,C.D., Villanti,A.C., Wackowski,O.A., Gundersen,D.A., Giovenco,D.P. Original/Translated Title URL Date of Electronic 20150804 PMCID PMC4740271 Editors
The influence of gingival dimensions on bleeding upon probing in young adults with plaque-induced gingivitis	2002	Department of Surgical Sciences, Faculty of Dentistry, Kuwait University, Safat. hp.muller@hsc.kuniv.edu.kw	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical oral investigations Periodical, Abbrev. Clin.Oral Investig. Pub Date Free Form Jun Volume 6 Issue 2 Start Page 69 Other Pages 74 Notes LR: 20071115; JID: 9707115; ppublish Place of Publication Germany ISSN/ISBN 1432-6981; 1432-6981 Accession Number PMID: 12166716 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; D DOI Output Language Unknown(0) PMID 12166716 Abstract In both cross-sectional and longitudinal studies of young adults with plaque-induced gingivitis it has been observed that bleeding upon probing is only weakly associated with supragingival plaque. It has been speculated that gingival bleeding may be influenced by several independent factors other than plaque. Great intra- and interindividual variation of gingival thickness and width has been reported. Based on respective observations, the existence of different gingival phenotypes has been suggested. The aim of the present study was to investigate the possible influence of gingival thickness and width on bleeding on probing. Forty young adults with mild, plaque-induced gingivitis, 24 non-smokers and 16 smokers, participated in this cross-sectional study. In addition to periodontal probing depth, clinical attachment loss, width of gingiva, bleeding on probing, and presence of plaque, gingival thickness was measured with an ultrasonic device. Multivariable models were separately calculated for buccal, mandibular lingual, and palatal surfaces and generally adjusted for tooth type. Generalised Estimation Equation methodology was employed in order to adjust for correlated observations. Plaque was significantly associated with bleeding upon probing only at buccal sites (odds ratio 1.80, 95% confidence interval 1.19-2.72) An influence of similar magnitude was identified for smoking (odds ratio 1.76; 1.07-2.89). At lingual sites in the mandible, bleeding was influenced by smoking (odds ratio 2.25; 1.18-4.25) and gingival thickness (odds ratio for thick gingiva >1 mm of 1.93; 1.02-3.65), but not plaque. At palatal sites, only periodontal probing depth had an influence (odds ratio 1.89; 1.25-2.84). It was concluded that, apart from supragingival plaque, smoking was an independent risk factor for gingival bleeding on probing. Thin and vulnerable gingiva of insufficient width was not more likely to bleed after probing than thicker tissue. Descriptors Adult, Cheek, Confidence Intervals, Cross-Sectional Studies, Dental Plaque/complications, Female, Gingiva/pathology/ultrasonography, Gingival Hemorrhage/classification/etiology, Gingivitis/etiology, Humans, Incisor, Lip, Logistic Models, Male, Mandible, Maxilla, Molar, Multivariate Analysis, Odds Ratio, Palate, Periodontal Attachment Loss/classification, Periodontal Index, Periodontal Pocket/classification, Reproducibility of Results, Risk Factors, Smoking, Statistics as Topic Links Book Title Database Publisher Data Source Authors Muller,H. P., Heinecke,A. Original/Translated Title URL Date of Electronic PMCID Editors
The indigenous Sea Gypsy divers of Thailand's west coast: measurement of carbon monoxide in the breathing air	1999	International Labor Office, Geneva, Switzerland.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Applied Occupational and Environmental Hygiene Periodical, Abbrev. Appl.Occup.Environ.Hyg. Pub Date Free Form Jul Volume 14 Issue 7 Start Page 488 Other Pages 495 Notes LR: 20131121; JID: 9103256; 0 (Air Pollutants, Occupational); 7U1EE4V452 (Carbon Monoxide); ppublish Place of Publication ENGLAND ISSN/ISBN 1047-322X; 1047-322X Accession Number PMID: 10461405 Language eng SubFile Journal Article; IM DOI Output Language Unknown(0) PMID 10461405 Abstract Approximately 400 indigenous divers live and work on Thailand's west coast. They dive with surface supplied air from primitive compressor units mounted on open boats which measure from seven to 11 meters in length. It was suspected that carbon monoxide was present in the breathing air of at least the gasoline-driven compressor units. To determine the presence of carbon monoxide gas in the breathing air, compressed air from the compressor was pumped through the diver air supply hose through a plenum (monitoring) chamber established on the boat. After a compressor warm-up of 15 minutes, the diving air was measured with the boat at eight different bearings to the wind, each 45 degrees apart at intervals of five minutes. Three of the four gasoline-driven compressor units tested showed presence of carbon monoxide in the breathing air. One diesel-driven unit showed a very low concentration of carbon monoxide (3-4 ppm) and six diesel-driven units showed no detectable carbon monoxide. Although not tested, diesel exhaust emissions could also enter the breathing air by the same route. A locally made modification to the compressor air intake was designed and successfully tested on one gasoline-driven compressor unit. An information sheet on the hazards of carbon monoxide as well as on the modification has been developed for distribution among the villages. Descriptors Air/analysis, Air Pollutants, Occupational/analysis, Carbon Monoxide/analysis, Diving, Equipment Safety, Humans, Occupational Exposure/prevention & control, Thailand Links Book Title Database Publisher Data Source Authors Gold,D., Geater,A., Aiyarak,S., Juengpraert,W. Original/Translated Title URL Date of Electronic PMCID Editors
The independent effects of second hand smoke exposure and maternal body mass index on the anthropometric measurements of the newborn	2013	Sheikh Bahamdan Research Chair of Evidence-based Healthcare and Knowledge translation, College of Medicine, King Saud University, P,O Box 102799, Riyadh 11685, Kingdom of Saudi Arabia. umlena@yahoo.com.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 9-Nov Volume 13 Issue Start Page 1058 Other Pages 2458-13-1058 Notes LR: 20150422; JID: 100968562; 0 (Tobacco Smoke Pollution); OID: NLM: PMC4226006; 2013/07/12 [received]; 2013/11/07 [accepted]; 2013/11/09 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 24209496 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1186/1471-2458-13-1058 [doi] Output Language Unknown(0) PMID 24209496 Abstract BACKGROUND: Exposure to tobacco smoke during pregnancy, whether as active smoking or by exposure to secondhand smoke (SHS), is associated with adverse pregnancy outcomes including low birth weight (LBW) and small for gestational age infants due to the effect of tobacco on the anthropometric measurements of the newborn. This effect might be masked by maternal obesity as it increases fetal weight. The objectives of this study were to estimate the independent effects of maternal exposure to SHS and maternal body mass index (BMI) on the anthropometric measurements and on the prevalence of macrosomia and LBW among term infants. METHODS: Data were collected from women in the postnatal ward following delivery. Participants were stratified into six groups based on the BMI (underweight /=30 kg/m(2)) and the SHS exposure status (exposed and non- exposed), to examine the independent effects of BMI and SHS on infants' anthropometry. Multiple regression analysis was used to explore the independent associations between the six groups and the risk of delivering a macrosomic or LBW infant. RESULTS: Infants of women exposed to SHS had significantly reduced anthropometric measurements compared to infants of unexposed women. The odds of delivering a macrosomic baby increased to 9-fold for women with BMI of >/=30 kg/m(2) compared to non-obese women; odds ratio (OR) 9.18, 95% Confidence Interval (CI) (1.01, 9.37); p = 0.04, this risk was attenuated to 1.5-fold in women exposed to SHS, OR 1.53, 95% CI (1.19, 12.1); p Descriptors Links Book Title Database Publisher Data Source Authors Wahabi,H.A., Mandil,A.A., Alzeidan,R.A., Bahnassy,A.A., Fayed,A.A. Original/Translated Title URL Date of Electronic 20131109 PMCID PMC4226006 Editors
The importance of social media for patients and families affected by congenital anomalies: A Facebook cross-sectional analysis and user survey	2016	Department of Paediatric and Neonatal Surgery, St. George's University Hospitals NHS Foundation Trust, London SW17 0QT, United Kingdom.; St. George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.; Department of Paediatric and Neo	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of pediatric surgery Periodical, Abbrev. J.Pediatr.Surg. Pub Date Free Form 28-Jul Volume Issue Start Page Other Pages Notes LR: 20160814; CI: Copyright (c) 2016; JID: 0052631; OTO: NOTNLM; 2016/02/21 [received]; 2016/07/13 [revised]; 2016/07/18 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1531-5037; 0022-3468 Accession Number PMID: 27522307 Language ENG SubFile JOURNAL ARTICLE DOI S0022-3468(16)30190-7 [pii] Output Language Unknown(0) PMID 27522307 Abstract BACKGROUND: We aimed to define characteristics and needs of Facebook users in relation to congenital anomalies. METHODS: Cross-sectional analysis of Facebook related to four congenital anomalies: anorectal malformation (ARM), congenital diaphragmatic hernia (CDH), congenital heart disease (CHD) and hypospadias/epispadias (HS/ES). A keyword search was performed to identify relevant Groups/Pages. An anonymous survey was posted to obtain quantitative/qualitative data on users and their healthcare needs. RESULTS: 54 Groups and 24 Pages were identified (ARM: 10 Groups; CDH: 9 Groups, 7 Pages; CHD: 32 Groups, 17 Pages; HS/ES: 3 Groups), with 16,191 Group members and 48,766 Page likes. 868/1103 (79%) of respondents were parents. Male:female ratio was 1:10.9. 65% of the users were 26-40years old. Common reasons for joining these Groups/Pages included: seeking support, education, making friends, and providing support to others. 932/1103 (84%) would like healthcare professionals (HCPs) to actively participate in their Group. 31% of the respondents felt that they did not receive enough support from their healthcare system. 97% of the respondents would like to join a Group linked to their primary hospital. CONCLUSIONS: Facebook Groups/Pages related to congenital anomalies are highly populated and active. There is a need for HCPs and policy makers to better understand and participate in social media to support families and improve patient care. Descriptors Links Book Title Database Publisher Elsevier Inc Data Source Authors Jacobs,R., Boyd,L., Brennan,K., Sinha,C.K., Giuliani,S. Original/Translated Title URL Date of Electronic 20160728 PMCID Editors
The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium	2012	Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. lubinj@mail.nih.gov	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Cancer epidemiology Periodical, Abbrev. Cancer.Epidemiol. Pub Date Free Form Jun Volume 36 Issue 3 Start Page 306 Other Pages 316 Notes LR: 20150325; CI: Published by Elsevier Ltd.; GR: CA59636/CA/NCI NIH HHS/United States; GR: K05 CA124911/CA/NCI NIH HHS/United States; GR: P30 CA015704/CA/NCI NIH HHS/United States; GR: R01 CA57947-03/CA/NCI NIH HHS/United States; GR: R01 DK063616/DK/NIDD Place of Publication Netherlands ISSN/ISBN 1877-783X; 1877-7821 Accession Number PMID: 22504051 Language eng SubFile Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.canep.2012.03.001 [doi] Output Language Unknown(0) PMID 22504051 Abstract BACKGROUND: Cigarette smoking is associated with esophageal adenocarcinoma (EAC), esophagogastric junctional adenocarcinoma (EGJA) and esophageal squamous cell carcinoma (ESCC), and alcohol consumption with ESCC. However, no analyses have examined how delivery rate modifies the strength of odds ratio (OR) trends with total exposure, i.e., the impact on the OR for a fixed total exposure of high exposure rate for short duration compared with low exposure rate for long duration. METHODS: The authors pooled data from 12 case-control studies from the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium (BEACON), including 1242 (EAC), 1263 (EGJA) and 954 (ESCC) cases and 7053 controls, modeled joint ORs for cumulative exposure and exposure rate for cigarette smoking and alcohol consumption, and evaluated effect modification by sex, body mass index (BMI), age and self-reported acid reflux. RESULTS: For smoking, all sites exhibited inverse delivery rate effects, whereby ORs with pack-years increased, but trends weakened with increasing cigarettes/day. None of the examined factors modified associations, except for ESCC where younger ages at diagnosis enhanced smoking effects (P Descriptors Links Book Title Database Publisher Data Source Authors Lubin,J.H., Cook,M.B., Pandeya,N., Vaughan,T.L., Abnet,C.C., Giffen,C., Webb,P.M., Murray,L.J., Casson,A.G., Risch,H.A., Ye,W., Kamangar,F., Bernstein,L., Sharp,L., Nyren,O., Gammon,M.D., Corley,D.A., Wu,A.H., Brown,L.M., Chow,W.H., Ward,M.H., Freedman,N.D., Whiteman,D.C. Original/Translated Title URL Date of Electronic 20120413 PMCID PMC3489030 Editors

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