WTS database

Title Sort descending	Pub Year	Author	SearchLink
Bacteriological studies on the problem of the usefulness of polystyrol products in drinking water pipes.	1960	Schmidt, B.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Archiv fÃ¼r Hygiene und Bakteriologie Periodical, Abbrev. Arch.Hyg.Bakteriol. Pub Date Free Form / Volume 178 Issue Start Page 381 Other Pages 392 Notes Place of Publication ISSN/ISBN 0003-9144 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Descriptors polystyrene derivative, article, microbiology, POLYSTYRENES/pharmacology, water supply, WATER SUPPLY/microbiology Links Book Title Database MEDLINE Publisher Data Source Embase Authors Schmidt,B. Original/Translated Title URL Date of Electronic PMCID Editors
Bangladesh: lessons learnt from two service strategies employed in Matlab	1983		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Asian-Pacific population programme news Periodical, Abbrev. Asian Pac.Popul.Programme News. Pub Date Free Form Volume 12 Issue 4 Start Page 25 Other Pages 27 Notes LR: 20141009; JID: 8010275; OID: PIP: 020093; OID: POP: 00130444; OTO: PIP; GN: PIP: TJ: ASIAN-PACIFIC POPULATION PROGRAMME NEWS; ppublish Place of Publication THAILAND ISSN/ISBN 0125-6718; 0125-6718 Accession Number PMID: 12312729 Language eng SubFile Journal Article; J DOI Output Language Unknown(0) PMID 12312729 Abstract PIP: In late 1975 the International Center for Diarrheal Disease Research, Bangladesh (ICDDR,B) initiated a contraceptive distribution program (CDP) in its field research area in Matlab thana (county) in rural Bangladesh. The project had a dual purpose: to confirm the existence of an unmet demand for contraception; and to assess to what degree it could be met by simply making oral contraceptives (OCs) and condoms available to every household. A total of 154 lady village workers (LVWs) were trained to work as distributors and depot holders of contraceptives. 1 LVW was responsible for about 200 families in the neighborhood of her residence. The initial results of the CDP were encouraging, but the prevalence of contraceptive practice declined thereafter to what appeared to be a plateau of 12% in the 2nd year of the program. This led to substantial modification in the field structure and program activities of the original CDP in late 1977. The modified program replaced the LVWs by a cadre of better educated and better trained female village workers (FVWs), backed up by a strong supervision and technical staff in 70 villages to provide a full range of contraceptives and selected maternal and child health (MCH) services. A group of 20 FVWs is assigned to a subcenter that is staffed by a full time paramedic to provide routine MCH services, IUD services, and referral support. Work routines require each FVW to visit all currently married women of reproductive age of her area fortnightly and to attend meetings at the subcenter to report on progress. The project has 1 woman physician who does regular rounds in the field and provides professional support to a central sterilization clinic in Matlab. 3 components of the project have been fully implemented thus far: family planning services, tetanus immunization, and diarrheal disease treatment. The project effect was a prompt and continuing increase in contraceptive use prevalence rates. The proportion of married women of reproductive age using contraceptives rose rapidly to 32% in the 1st year and stayed at 33% in the 2nd year. The project has been maintaining this use prevalence rate for the last 4 years with only a slight increase to 34% more recently. 1 important observation of the Matlab project is that acceptors tend to cluster geographically producing a wide intervillage variation in contraceptive use prevalence rates. Given the free household distribution of contraceptives by the project, the question arises as to why rates differ among a population which appears to be so homogeneous. Descriptors Asia, Bangladesh, Community Health Workers, Contraception, Contraception Behavior, Delivery of Health Care, Demography, Developing Countries, Family Planning Services, Health, Health Personnel, Health Planning, Health Services, Maternal-Child Health Centers, Organization and Administration, Population Control, Primary Health Care, Contraceptive Distribution, Contraceptive Usage, Demographic Effectiveness, Demographic Impact, Distributional Activities, Family Planning, Family Planning Personnel, Family Planning Programs, Field Workers, Integrated Programs, Maternal-child Health Services, Nonclinical Distribution, Program Activities, Programs, Southern Asia Links Book Title Database Publisher Data Source Authors Rahman,M., Ruzicka,L. Original/Translated Title URL Date of Electronic PMCID Editors
Barotrauma and decompression illness of the inner ear: 46 cases during treatment and follow-up	2007	Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany. christoph_klingmann@med.uni-heidelberg.de	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology Periodical, Abbrev. Otol.Neurotol. Pub Date Free Form Jun Volume 28 Issue 4 Start Page 447 Other Pages 454 Notes LR: 20131121; JID: 100961504; 0 (Anti-Inflammatory Agents); 9PHQ9Y1OLM (Prednisolone); ppublish Place of Publication United States ISSN/ISBN 1531-7129; 1531-7129 Accession Number PMID: 17417111 Language eng SubFile Journal Article; IM DOI 10.1097/MAO.0b013e318030d356 [doi] Output Language Unknown(0) PMID 17417111 Abstract INTRODUCTION: Diving accidents affecting the inner ear are much more common than was once thought. Among the 319 patients treated in our clinic between January 2002 and November 2005, 46 cases involved 44 divers with symptoms of acute inner ear disorders. The objective of the present article is to investigate the symptoms of the acute disorders and assess any residual damage. STUDY DESIGN: Retrospective case analysis. MATERIALS AND METHODS: The medical records were used to study the cases of 18 divers treated for inner ear decompression illness on 20 occasions and 26 divers who had inner ear barotrauma. The symptoms of the disorder at the beginning of treatment, latency period before the first therapeutic measures, kind of initial therapy, symptoms after the accident, and hearing and balance functions at the last examination in our clinic were assessed. Divers with inner ear decompression illness were examined via means of transcranial or carotid Doppler ultrasonography for the presence of a vascular right-to-left (R/L) shunt. RESULTS: Of 18 divers with inner ear decompression illness, 17 reported vertigo as the main symptom. In one diver, the inner ear decompression illness was manifested bilaterally. The divers with inner ear decompression illness had been treated with hyperbaric oxygen therapy in 14 of 20 cases; the average latency period before the start of therapy was 40 hours (median, 10 h). In 15 (83%) of 18 patients, a large R/L shunt was detected, and in 14 (78%) of 18 patients, residual cochleovestibular damage was detected. Only 9 of 26 patients with inner ear barotrauma mentioned feeling dizzy, and in no patient was vertigo the main symptom. Twenty-one patients complained of tinnitus, whereas 20 complained of hearing loss. The hearing loss ranged from an unobtrusive difference of 10 dB between the ears up to complete deafness. Three patients were subjected to tympanoscopy because of suspected rupture of the round window membrane. Of patients with inner ear barotrauma, 78% had residual cochleovestibular damage. CONCLUSION: We describe for the first time a patient with bilateral manifestation of inner ear decompression illness. Inner ear decompression illness is frequently associated with a R/L shunt; therefore, after a diving accident, the patient's fitness to dive should be assessed via a specialist in diving medicine. Both decompression illness and barotrauma of the inner ear result in residual cochleovestibular damage in more than three of four patients. Descriptors Adult, Anti-Inflammatory Agents/therapeutic use, Audiometry, Barotrauma/complications/therapy/ultrasonography, Decompression Sickness/complications/therapy/ultrasonography, Ear, Inner/injuries/ultrasonography, Female, Follow-Up Studies, Functional Laterality, Hearing Loss/etiology, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Prednisolone/therapeutic use, Pulmonary Heart Disease/complications/ultrasonography, Retrospective Studies, Vertigo/etiology Links Book Title Database Publisher Data Source Authors Klingmann,C., Praetorius,M., Baumann,I., Plinkert,P. K. Original/Translated Title URL Date of Electronic PMCID Editors
Barrett esophagus and risk of esophageal cancer: a clinical review	2013	VA North Texas Healthcare System, Dallas, Texas, USA. sjspechler@aol.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Jama Periodical, Abbrev. JAMA Pub Date Free Form 14-Aug Volume 310 Issue 6 Start Page 627 Other Pages 636 Notes LR: 20140917; JID: 7501160; ppublish Place of Publication United States ISSN/ISBN 1538-3598; 0098-7484 Accession Number PMID: 23942681 Language eng SubFile Clinical Conference; Journal Article; Review; AIM; IM DOI 10.1001/jama.2013.226450 [doi] Output Language Unknown(0) PMID 23942681 Abstract IMPORTANCE: Barrett esophagus, a complication of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma, a tumor that has increased in incidence more than 7-fold over the past several decades. Controversy exists regarding the issues of endoscopic screening and surveillance for Barrett esophagus, treatment for the underlying GERD, and the role of endoscopic eradication therapy. OBJECTIVES: To review current concepts on the pathogenesis, diagnosis, and treatment of Barrett esophagus; to discuss the importance of dysplasia and the role of endoscopic eradication therapy for its treatment; and to review current management guidelines. EVIDENCE REVIEW: MEDLINE and the Cochrane Library were searched from 1984 to April 2013. Additional citations were obtained by reviewing references from selected research and review articles. FINDINGS: Risk factors for cancer in Barrett esophagus include chronic GERD, hiatal hernia, advanced age, male sex, white race, cigarette smoking, and obesity with an intra-abdominal body fat distribution. The annual risk of esophageal cancer is approximately 0.25% for patients without dysplasia and 6% for patients with high-grade dysplasia. High-quality studies have found no significant differences in cancer incidence for patients with Barrett esophagus whose GERD is treated medically or surgically. Endoscopic eradication therapy with radiofrequency ablation significantly reduces the frequency of progression to cancer for patients with high-grade dysplasia. CONCLUSIONS AND RELEVANCE: Endoscopic screening is recommended for patients with multiple risk factors for cancer in Barrett esophagus. For patients with Barrett esophagus without dysplasia, endoscopic surveillance at intervals of 3 to 5 years is recommended, and GERD is treated much as it is for patients without Barrett esophagus. Endoscopic eradication therapy is the treatment of choice for high-grade dysplasia and is an option for low-grade dysplasia. Endoscopic eradication therapy is not recommended for the general population of patients with nondysplastic Barrett esophagus. Descriptors Links Book Title Database Publisher Data Source Authors Spechler,S.J. Original/Translated Title URL Date of Electronic PMCID Editors
Barrett esophagus in Asia: same disease with different pattern	2014	Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.; Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical endoscopy Periodical, Abbrev. Clin.Endosc. Pub Date Free Form Jan Volume 47 Issue 1 Start Page 15 Other Pages 22 Notes LR: 20140624; JID: 101576886; OID: NLM: PMC3928486; OTO: NOTNLM; 2013/12/01 [received]; 2013/12/16 [revised]; 2014/01/02 [accepted]; 2014/01/24 [epublish]; ppublish Place of Publication Korea (South) ISSN/ISBN 2234-2400; 2234-2400 Accession Number PMID: 24570879 Language eng SubFile Journal Article; Review DOI 10.5946/ce.2014.47.1.15 [doi] Output Language Unknown(0) PMID 24570879 Abstract Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia. Descriptors Links Book Title Database Publisher Data Source Authors Lee,H.S., Jeon,S.W. Original/Translated Title URL Date of Electronic 20140124 PMCID PMC3928486 Editors
Barrett's esophagus and beta-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa	2012	Department of Medicine, University of Maryland School of Medicine and Division Director of Gastroenterology, USA. sdutta@lifebridgehealth.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Asian Pacific journal of cancer prevention : APJCP Periodical, Abbrev. Asian Pac.J.Cancer.Prev. Pub Date Free Form Volume 13 Issue 12 Start Page 6011 Other Pages 6016 Notes JID: 101130625; 0 (HSP70 Heat-Shock Proteins); 01YAE03M7J (beta Carotene); ppublish Place of Publication Thailand ISSN/ISBN 1513-7368; 1513-7368 Accession Number PMID: 23464395 Language eng SubFile Journal Article; IM DOI Output Language Unknown(0) PMID 23464395 Abstract INTRODUCTION: Epidemiological studies suggest a protective role for beta-carotene with several malignancies. Esophageal adenocarcinoma frequently arises from Barrett's esophagus (BE). We postulated that beta-carotene therapy maybe protective in BE. MATERIALS AND METHOD: We conducted a prospective study in which 25 mg of beta-carotene was administered daily for six-months to six patients. Each patient underwent upper endoscopy before and after therapy and multiple mucosal biopsies were obtained. Additionally, patients completed a gastroesophageal reflux disease (GERD) symptoms questionnaire before and after therapy and severity score was calculated. To study the effect of beta-carotene at molecular level, tissue extracts of the esophageal mucosal biopsy were subjected to assessment of heat-shock protein 70 (HSP70). RESULTS: A significant (p Descriptors Links Book Title Database Publisher Data Source Authors Dutta,S.K., Agrawal,K., Girotra,M., Fleisher,A.S., Motevalli,M., Mah'moud,M.A., Nair,P.P. Original/Translated Title URL Date of Electronic PMCID Editors
Barrett's esophagus in children and adolescents without neurodevelopmental or tracheoesophageal abnormalities: a prospective study	2011	Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Gastrointestinal endoscopy Periodical, Abbrev. Gastrointest.Endosc. Pub Date Free Form May Volume 73 Issue 5 Start Page 875 Other Pages 880 Notes LR: 20151119; CI: Copyright (c) 2011; GR: 1-R03-DK068148-01/DK/NIDDK NIH HHS/United States; GR: K24 DK078154/DK/NIDDK NIH HHS/United States; GR: K24 DK078154-04/DK/NIDDK NIH HHS/United States; GR: P30 DK056338/DK/NIDDK NIH HHS/United States; GR: P30 DK056 Place of Publication United States ISSN/ISBN 1097-6779; 0016-5107 Accession Number PMID: 21354565 Language eng SubFile Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI 10.1016/j.gie.2011.01.017 [doi] Output Language Unknown(0) PMID 21354565 Abstract BACKGROUND: Barrett's esophagus (BE) in children has been examined in retrospective studies, consisting of case series and cross-sectional studies. OBJECTIVE: To evaluate the prevalence and determinants of BE in children who are free from neurodevelopmental disorders and tracheoesophageal abnormalities. DESIGN: A prospective, cross-sectional study. SETTING: Three pediatric GI Centers in Houston, Texas; Phoenix, Arizona; and Portland, Maine between February 2006 and December 2007. PATIENTS: This study involved children and adolescents consecutively presenting for elective upper endoscopy. Patients with neurodevelopmental and tracheoesophageal disorders were excluded. INTERVENTION: Endoscopic pictures of all cases with suspected BE were independently reviewed and verified by two experienced investigators. Esophageal biopsy specimens were obtained in all patients, and targeted biopsy specimens also were obtained from suspected BE. MAIN OUTCOME MEASUREMENTS: Endoscopically suspected BE and histologically confirmed BE. RESULTS: A total of 840 patients (mean age 9.5 years) were enrolled and had complete questionnaire and endoscopic data. Twelve patients were suspected of having BE (prevalence of 1.43%; 95% confidence interval [CI], 0.73-2.45), and only 1 patient had intestinal metaplasia, for a prevalence of 0.12% (95% CI, 0-0.65), whereas the rest had gastric oxyntic glands (n=6) or squamous esophageal epithelium (n=5). Patients with suspected BE had a higher mean body mass index (23.0 vs 19.1, P=.05) and more chest pain (50% vs 13%, P<.01 than="" patients="" without="" be="" or="" reflux="" esophagitis.="" there="" was="" a="" trend="" toward="" higher="" frequency="" of="" dysphagia="" heartburn="" and="" regurgitation="" in="" with="" suspected="" be.="" limitations:="" the="" accuracy="" prevalence="" estimates="" is="" limited="" by="" small="" number="" cases.="" conclusion:="" rare="" children="" neurodevelopmental="" delay="" tracheoesophageal="" anomalies="" presenting="" for="" elective="" upper="" endoscopy.=""> Descriptors Links Book Title Database Publisher American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc Data Source Authors Nguyen,D.M., El-Serag,H.B., Shub,M., Integlia,M., Henderson,L., Richardson,P., Fairly,K., Gilger,M.A. Original/Translated Title URL Date of Electronic 20110226 PMCID PMC3083476 Editors
Barrett's esophagus: its diagnosis and management in Japan	2015		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nihon rinsho.Japanese journal of clinical medicine Periodical, Abbrev. Nihon Rinsho. Pub Date Free Form Jul Volume 73 Issue 7 Start Page 1129 Other Pages 1135 Notes JID: 0420546; ppublish Place of Publication Japan ISSN/ISBN 0047-1852; 0047-1852 Accession Number PMID: 26165069 Language jpn SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 26165069 Abstract The incidence of adenocarcinoma derived from Barrett's esophagus has been steadily increasing during the past some decades in Western countries. The development of better diagnostic and therapeutic strategies for Barrett's esophagus and Barrett's adenocarcinoma have become an important objective. In Japan, Barrett's adenocarcinoma has been gradually increasing as the results of a high incidence of reflux esophagitis, a decreasing of Helicobacter pylori infection and an increasing of obesity, etc. Subsequently, in recent, the management of Barrett's esophagus has come to be of interest as well as in the Western countries. Many issues found in the pathophysiology and epidemiology of Barrett's esophagus in Japanese patients are required to be clarified and the Japanese maneuvers regarding the diagnostic procedure and clinical management including the surveillance for patients with Barrett's esophagus should be established as soon as possible. Descriptors Links Book Title Database Publisher Data Source Authors Amano,Y., Azumi,T. Original/Translated Title URL Date of Electronic PMCID Editors
Barrett's oesophagus: Evidence from the current meta-analyses	2014	Piers Gatenby, Division of Surgery and Interventional Science, University College London, London NW32QG, United Kingdom.; Piers Gatenby, Division of Surgery and Interventional Science, University College London, London NW32QG, United Kingdom.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full World journal of gastrointestinal pathophysiology Periodical, Abbrev. World J.Gastrointest.Pathophysiol. Pub Date Free Form 15-Aug Volume 5 Issue 3 Start Page 178 Other Pages 187 Notes LR: 20140820; JID: 101547471; OID: NLM: PMC4133517; OTO: NOTNLM; 2013/12/31 [received]; 2014/04/05 [revised]; 2014/05/29 [accepted]; ppublish Place of Publication United States ISSN/ISBN 2150-5330; 2150-5330 Accession Number PMID: 25133020 Language eng SubFile Journal Article; Review DOI 10.4291/wjgp.v5.i3.178 [doi] Output Language Unknown(0) PMID 25133020 Abstract Guidelines have been published regarding the management of Barrett's oesophagus (columnar-lined oesophagus). These have examined the role of surveillance in an effort to detect dysplasia and early cancer. The guidelines have provided criteria for enrolment into surveillance and some risk stratification with regard to surveillance interval. The research basis for the decisions reached with regard to cancer risk is weak and this manuscript has examined the available data published from meta-analyses up to 25(th) April 2013 (much of which has been published since the guidelines and their most recent updates have been written). There were 9 meta-analyses comparing patients with Barrett's oesophagus to control populations. These have demonstrated that Barrett's oesophagus is more common in males than females, in subjects who have ever smoked, in subjects with obesity, in subjects with prolonged symptoms of gastro-oesophageal reflux disease, in subjects who do not have infection with Helicobacter pylori and in subjects with hiatus hernia. These findings should inform public health measures in reducing the risk of Barrett's oesophagus and subsequent surveillance burden and cancer risk. There were 8 meta-analyses comparing different groups of patients with Barrett's oesophagus with regard to cancer risk. These have demonstrated that there was no statistically significant benefit of antireflux surgery over medical therapy, that endoscopic ablative therapy was effective in reducing cancer risk that there was similar cancer risk in patients with Barrett's oesophagus independent of geographic origin, that the adenocarcinoma incidence in males is twice the rate in females, that the cancer risk in long segment disease showed a trend to be higher than in short segment disease, that there was a trend for higher cancer risk in low-grade dysplasia over non-dysplastic Barrett's oesophagus, that there is a lower risk in patients with Helicobacter pylori infection and that there is a significant protective effect of aspirin and statins. There were no meta-analyses examining the role of intestinal metaplasia. These results demonstrate that guidance regarding surveillance based on the presence of intestinal metaplasia, segment length and the presence of low-grade dysplasia has a weak basis, and further consideration should be given to gender and helicobacter status, ablation of the metaplastic segment as well as the chemoprotective role of aspirin and statins. Descriptors Links Book Title Database Publisher Data Source Authors Gatenby,P., Soon,Y. Original/Translated Title URL Date of Electronic PMCID PMC4133517 Editors
Barrett's esophagus: a surgical disease	1999	Department of Surgery, University of California, San Francisco, San Francisco, California 94143-0788, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Periodical, Abbrev. J.Gastrointest.Surg. Pub Date Free Form Jul-Aug Volume 3 Issue 4 Start Page 397 Other Pages 403; discussion 403-4 Notes LR: 20041117; JID: 9706084; ppublish Place of Publication UNITED STATES ISSN/ISBN 1091-255X; 1091-255X Accession Number PMID: 10482692 Language eng SubFile Journal Article; IM DOI S1091255X99800560 [pii] Output Language Unknown(0) PMID 10482692 Abstract Barrett's metaplasia can develop in patients with gastroesophageal reflux disease (GERD), and metaplasia can evolve into dysplasia and adenocarcinoma. The optimal treatment for Barrett's metaplasia and dysplasia is still being debated. The study reported herein was designed to assess the following: (1) the incidence of Barrett's metaplasia among patients with GERD; (2) the ability of laparoscopic fundoplication to control symptoms in patients with Barrett's metaplasia; (3) the results of esophagectomy in patients with high-grade dysplasia; and (4) the character of endoscopic follow-up programs of patients with Barrett's disease being managed by physicians throughout a large geographic region (northern California). Five-hundred thirty-five patients evaluated between October 1989 and February 1997 at the University of California San Francisco Swallowing Center had a diagnosis of GERD established by upper gastrointestinal series, endoscopy, manometry, and pH monitoring. Thirty-eight symptomatic patients with GERD and Barrett's metaplasia underwent laparoscopic fundoplication. Eleven other consecutive patients with high-grade dysplasia underwent transhiatal esophagectomies. Barrett's metaplasia was present in 72 (13%) of the 535 patients with GERD. The following results were achieved in patients who underwent laparoscopic fundoplication (n = 38): Heartburn resolved in 95% of patients, regurgitation in 93% of patients, and cough in 100% of patients. With regard to transhiatal esophagectomy (n = 11), the average duration of the operation was 339 +/- 89 minutes. The only significant complications were two esophageal anastomotic leaks, both of which resolved without sequelae. Mean hospital stay was 14 +/- 5 days. There were no deaths. The specimens showed high-grade dysplasia in seven patients and invasive adenocarcinoma (undiagnosed preoperatively) in four (36%). These results can be summarized as follows: (1) Barrett's metaplasia was present in 13% of patients with GERD being evaluated at a busy diagnostic center; (2) laparoscopic fundoplication was highly successful in controlling symptoms of GERD in patients with Barrett's metaplasia; (3) in patients with high-grade dysplasia esophagectomy was performed safely (invasive cancer had eluded preoperative endoscopic biopsies in one third of these patients); and (4) even though periodic endoscopic examination of Barrett's disease is universally recommended, this was actually done in fewer than two thirds of patients being managed by a large number of independent physicians in this geographic area. Descriptors Adenocarcinoma/pathology, Adult, Aged, Aged, 80 and over, Anastomosis, Surgical/adverse effects, Barrett Esophagus/etiology/pathology/surgery, California, Cough/therapy, Esophageal Neoplasms/pathology, Esophagectomy/adverse effects, Esophagoscopy, Esophagus/pathology, Female, Follow-Up Studies, Fundoplication, Gastroesophageal Reflux/complications, Heartburn/therapy, Humans, Hydrogen-Ion Concentration, Incidence, Laparoscopy, Length of Stay, Male, Manometry, Metaplasia, Middle Aged, Monitoring, Ambulatory, Time Factors Links Book Title Database Publisher Data Source Authors Patti,M. G., Arcerito,M., Feo,C. V., Worth,S., De Pinto,M., Gibbs,V. C., Gantert,W., Tyrrell,D., Ferrell,L. F., Way,L. W. Original/Translated Title URL Date of Electronic PMCID Editors

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