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Growth-supporting activity for Legionella pneumophila in tap water cultures and implication of hartmannellid amoebae as growth factors 1988 Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Applied and Environmental Microbiology
Periodical, Abbrev.
Appl.Environ.Microbiol.
Pub Date Free Form
Nov
Volume
54
Issue
11
Start Page
2677
Other Pages
2682
Notes
LR: 20131001; JID: 7605801; OID: NLM: PMC204355; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0099-2240; 0099-2240
Accession Number
PMID: 3214153
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
3214153
Abstract
Photosynthetic cyanobacteria, heterotrophic bacteria, free-living amoebae, and ciliated protozoa may support growth of Legionella pneumophila. Studies were done with two tap water cultures (WS1 and WS2) containing L. pneumophila and associated microbiota to characterize growth-supporting activity and assess the relative importance of the microbiota in supporting multiplication of L. pneumophila. The water cultures were incubated in the dark at 35 degrees C. The growth-supporting factor(s) was separated from each culture by filtration through 1-micron-pore-size membrane filters. The retentate was then suspended in sterile tap water. Multiplication of L. pneumophila occurred when both the retentate suspension and the filtrate from either culture were inoculated into sterile tap water. L. pneumophila did not multiply in tap water inoculated with only the filtrate, even though filtration did not reduce the concentration of L. pneumophila or heterotrophic bacteria in either culture. Growth-supporting activity of the retentate suspension from WS1 was inactivated at 60 degrees C but unaffected at 0, 25, and 45 degrees C after 30-min incubations. Filtration experiments indicated that the growth-supporting factor(s) in WS1 was 2 to 5 micron in diameter. Ciliated protozoa were not detected in either culture. Hartmannellid amoebae were conclusively demonstrated in WS2 but not in WS1. L. pneumophila multiplied in tap water inoculated with the amoebae (10(3)/ml) and the 1-micron filtrate of WS2. No multiplication occurred in tap water inoculated with the filtrate only. Growth-supporting activity for L. pneumophila may be present in plumbing systems; hartmannellid amoebae appear to be important determinants of multiplication of L. pneumophila in some tap water cultures.
Descriptors
Animals, Hartmannella/growth & development, Legionella/growth & development, Temperature, Water Microbiology, Water Supply
Links
Book Title
Database
Publisher
Data Source
Authors
Wadowsky,R. M., Butler,L. J., Cook,M. K., Verma,S. M., Paul,M. A., Fields,B. S., Keleti,G., Sykora,J. L., Yee,R. B.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC204355
Editors
Smoking in Morocco: an outline of the anti-smoking campaign 1988 Faculte de Medecine de Casablanca, Maroc.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Hygie
Periodical, Abbrev.
Hygie
Pub Date Free Form
Mar
Volume
7
Issue
1
Start Page
30
Other Pages
32
Notes
LR: 20061115; JID: 8304186; OID: PIP: 058308; OID: POP: 00190278; OTO: PIP; GN: PIP: TJ: HYGIE.; ppublish
Place of Publication
FRANCE
ISSN/ISBN
0751-7149; 0751-7149
Accession Number
PMID: 3371994
Language
fre
SubFile
English Abstract; Journal Article; IM; J
DOI
Output Language
Unknown(0)
PMID
3371994
Abstract
In Morocco, as in many developing countries, tobacco use has become a plague which aggravates the many already existing problems. A coordinated prevention programme which included research and a variety of educational efforts, has been underway for the past five years. The preliminary stage of the non-smoking campaign consisted of research through use of a variety of standardized questionnaires. The research results showed tobacco use in Morocco to be the following: 23.8% of secondary students are smokers with variation according to family, culture, environment and sex (33% male vs. 8.6% female); 33.8% of university students smoke, including those in Medical Schools; 52.1% of adults in the work environment smoke, including doctors. The rate declines drastically among practicing muslims (between the ages of 14 and 65) to 9.8%. The use of other drugs is significantly higher in students who use tobacco (25%) than those who do not (1.5%). A common factor appeared regardless of age, sex, or occupation: there was insufficient information available concerning the harmful effects of smoking. An educational campaign was therefore launched. As the youth were considered to be the most vulnerable target group, a major part of the educational efforts was concentrated on them. A variety of activities was implemented including conference-debates using audiovisual supports; radio and T.V. broadcasts; contests run with the assistance of the CIPADED (International Committee for the Prevention of Alcohol/Drug Dependence). Information of the harmful effects of tobacco use was diffused in workplaces, government offices, and at public assemblies. Efforts were also implemented to promote adoption of legislation which would limit tobacco consumption.(ABSTRACT TRUNCATED AT 250 WORDS); PIP: An antismoking campaign has several stages: understanding the epidemiology of smoking, directing actions toward the most vulnerable population sectors, and increasing the awareness of educators and political authorities of the problems of smoking. Surveys in Morocco between 1980-84 showed that 23.8% of secondary school students, 33.8% of university students including medical students, and 52.1% of working adults smoke. The lowest proportions of smokers are found in the most traditional cultural sectors. Among practicing Moslems, 13.4% of males and .4% of females smoke. 33% of male but only 8.6% of female secondary students smoke, and 58.2% of employed males but 14.9% of employed females smoke. Smokers often use other drugs or alcohol; up to 25% of smokers among university students in Casablanca also reported using alcohol, kif, or hashish, vs. only 1.5% of nonsmokers. The surveys all underscore the lack of knowledge of the harmful effects of smoking among smokers. The goal of the antismoking campaign is to demonstrate that not smoking is the normal behavior. A limited but coordinated antismoking campaign underway for 5 years in Morocco has been directed toward making young people aware of the dangers of tobacco. The Moroccan Association for Prevention and Health Education (AMAPES) has conducted conferences and debates with audiovisual support or demonstrations by a mechanical smoker in educational establishments and similar organizations. Radio and television broadcasts have been sponsored. AMAPES has attempted to increase awareness among physicians of the risks of smoking to their own health and of the poor example they set for patients. Personal contacts with influentials are intended to promote antismoking legislation. The educational activities stress the goals of preserving traditional values and promoting better health, quality of life, self-esteem, and confidence. The antismoking campaign has not yet been formally evaluated, but the volume of requests to the association for additional information about the dangers of smoking and the contemplation of new antismoking laws by Parliament indicate that the goal of sensitizing the population to the problems of toba
Descriptors
Adolescent, Adult, Child, Female, Health Education/methods/organization & administration, Humans, Islam, Male, Mass Media, Morocco, Smoking/prevention & control, Africa, Arab Countries, Behavior, Communication, Communication Programs, Demographic Factors, Developing Countries, Education, French Speaking Africa, Health, Health Education, Measurement, Mediterranean Countries, Northern Africa, Population, Population At Risk, Population Characteristics, Prevalence, Public Health, Research Methodology, Sex Factors, Smoking--prevention and control, Students
Links
Book Title
Database
Publisher
Data Source
Authors
Bartal,M., Bouayad,Z., Bahlaoui,A., Naciri,A., el Meziane,A.
Original/Translated Title
Le tabagisme au Maroc: ebauche de lutte antitabac
URL
Date of Electronic
PMCID
Editors
Estimates of maximum or average cigarette tar, nicotine, and carbon monoxide yields can be obtained from yields under standard conditions 1986
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Preventive medicine
Periodical, Abbrev.
Prev.Med.
Pub Date Free Form
Jan
Volume
15
Issue
1
Start Page
82
Other Pages
91
Notes
LR: 20151119; JID: 0322116; 0 (Smoke); 0 (Tars); 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); EIN: Prev Med 1987 Mar;16(2):290; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0091-7435; 0091-7435
Accession Number
PMID: 3714662
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
3714662
Abstract
Average yields of tar, nicotine, and carbon monoxide per liter of smoke and per cigarette were determined for 10 brands of cigarettes smoked under 27 different conditions (one standard and 26 nonstandard). Per cigarette yields were highly variable across smoking conditions due to differences in the total volume of smoke taken for analysis. The results of a simple linear regression analysis indicated that up to 95% of the variation in tar yield per cigarette could be explained by variations in the total volume of smoke produced per cigarette. Per liter yields for tar, nicotine, and carbon monoxide were almost constant over the conditions investigated. Since most smokers inhale less than this amount, yields per liter provide a rough estimate of the maximum amount to which a smoker might be exposed. Yields per liter, taken over all 26 conditions, are highly correlated with per cigarette yields under standard conditions. Consequently, values on one scale can be converted to the other, at least for the 10 brands investigated. The average conversion factor for tar, nicotine, and carbon monoxide is 2.5 when proceeding from milligrams per king-size cigarette under standard conditions to milligrams per liter. This relationship is true for both vented and nonvented cigarettes when ventilation holes are not blocked.
Descriptors
Carbon Monoxide/analysis, Methods, Nicotine/analysis, Plants, Toxic, Smoke/analysis, Smoking, Tars/analysis, Tobacco
Links
Book Title
Database
Publisher
Data Source
Authors
Rickert,W. S., Collishaw,N. E., Bray,D. F., Robinson,J. C.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Diving injuries to the inner ear 1977
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Annals of otology, rhinology & laryngology.Supplement
Periodical, Abbrev.
Ann.Otol.Rhinol.Laryngol.Suppl.
Pub Date Free Form
Jan-Feb
Volume
86
Issue
1 Pt 3 Suppl 36
Start Page
1
Other Pages
20
Notes
LR: 20080221; JID: 1256156; OID: NASA: 77132949; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0096-8056; 0096-8056
Accession Number
PMID: 402882
Language
eng
SubFile
Journal Article; AIM; IM; S
DOI
Output Language
Unknown(0)
PMID
402882
Abstract
Most of the previous literature concerning otologic problems in compressed gas environments has emphasized middle ear barotrauma. With recent increases in commercial, military, and sport diving to deeper depths, inner ear disturbances during these exposures have been noted more frequently. Studies of inner ear physiology and pathology during diving indicate that the causes and treatment of these problems differ depending upon the phase and type of diving. Humans exposed to simulated depths of up to 305 meters without barotrauma or decompression sickness develop transient, conductive hearing losses with no audiometric evidence of cochlear dysfunction. Transient vertigo and nystagmus during diving have been noted with caloric stimulation, resulting from the unequal entry of cold water into the external auditory canals, and with asymmetric middle ear pressure equilibration during ascent and descent (alternobaric vertigo). Equilibrium disturbances noted with nitrogen narcosis, oxygen toxicity, hypercarbia, or hypoxia appear primarily related to the effects of these conditions upon the central nervous system and not to specific vestibular end-organ dysfunction. Compression of humans in helium-oxygen at depths greater than 152.4 meters results in transient symptoms of tremor, dizziness, and nausea plus decrements in postural equilibrium and psychomotor performance, the high pressure nervous syndrome. Vestibular function studies during these conditions indicate that these problems are due to central dysfunction and not to vestibular end-organ dysfunction. Persistent inner ear injuries have been noted during several phases of diving: 1) Such injuries during compression (inner ear barotrauma) have been related to round window ruptures occurring with straining, or a Valsalva's maneuver during inadequate middle ear pressure equilibration. Divers who develop cochlear and/or vestibular symptoms during shallow diving in which decompression sickness is unlikely or during compression in deeper diving, should be placed on bed rest with head elevation and avoidance of maneuvers which result in increased cerebrospinal fluid and intralabyrinthine pressure. With no improvement in symptoms after 48 hours, exploratory tympanotomy and repair of a possible labyrinthine window fistula should be considered. Recompression therapy is contraindicated in these cases...
Descriptors
Action Potentials, Animals, Auditory Threshold, Cochlea/physiopathology, Cochlear Nerve/physiopathology, Deafness/physiopathology, Decompression, Decompression Sickness/physiopathology, Diving, Ear, Inner/physiopathology, Electroencephalography, Humans, Naval Medicine, Noise, Tinnitus/physiopathology, Tympanic Membrane/injuries, Vertigo/physiopathology, Vestibule, Labyrinth/physiopathology
Links
Book Title
Database
Publisher
Data Source
Authors
Farmer,J. C.,Jr
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
The effects of cigarette smoking on maximal oxygen consumption and selected physiological responses of elite team sportsmen 1985
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
European journal of applied physiology and occupational physiology
Periodical, Abbrev.
Eur.J.Appl.Physiol.Occup.Physiol.
Pub Date Free Form
Volume
53
Issue
4
Start Page
348
Other Pages
352
Notes
LR: 20081121; JID: 0410266; ppublish
Place of Publication
GERMANY, WEST
ISSN/ISBN
0301-5548; 0301-5548
Accession Number
PMID: 4039263
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
4039263
Abstract
The acute and chronic effects of cigarette smoking on selected physiological responses were determined in seven well-trained non-smokers and seven well-trained habitual smokers. Non-smokers and smokers did not differ significantly with respect to maximal oxygen consumption (VO2max). The acute effect of smoking two cigarettes immediately prior to a graded exercise stress test on a treadmill ergometer did not significantly alter the VO2max of either group. However, the time taken for non-smokers to reach exhaustion decreased significantly (F = 5.381, P less than 0.05) by a mean of 0.64 min. Smokers recorded lower scores for forced vital capacity (FVC) and forced expiratory volume in the 1st s exhalation (FEV1) than non-smokers. Only the mean FVC of smokers recorded 5 min post-exercise was significantly altered by pre-exercise smoking. No differences were found between the resting heart rates (HR) of non-smokers and smokers. Smoking two cigarettes significantly (F = 44.720, P less than 0.01) increased the mean resting HR of smokers and non-smokers by 15.8 beats X min-1 and 15.6 beats X min-1 respectively. No alteration to the exercise HR of either group was found under smoking conditions of the VO2max tests.
Descriptors
Adult, Exercise Test, Forced Expiratory Volume, Heart Rate, Humans, Male, Oxygen Consumption, Physical Education and Training, Physical Exertion, Rest, Self Concept, Smoking, Time Factors, Vital Capacity
Links
Book Title
Database
Publisher
Data Source
Authors
Morton,A. R., Holmik,E. V.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Association between smoking different tobacco products and periodontal disease indexes 1983
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of periodontology
Periodical, Abbrev.
J.Periodontol.
Pub Date Free Form
Aug
Volume
54
Issue
8
Start Page
481
Other Pages
487
Notes
LR: 20061115; JID: 8000345; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0022-3492; 0022-3492
Accession Number
PMID: 6578319
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; D; IM
DOI
10.1902/jop.1983.54.8.481 [doi]
Output Language
Unknown(0)
PMID
6578319
Abstract
Six indexes of periodontal health were recorded in cigarette smokers, pipe/cigar smokers and nonsmokers from the Veterans Administration Dental Longitudinal Study. These indexes included calculus deposition, plaque accumulation, gingival inflammation, periodontal pocket depth, alveolar bone loss and tooth mobility. Cigarette smokers had significantly more calculus deposition than pipe/cigar smokers, although both smoker groups had more calculus than nonsmokers. Cigarette smokers accumulated slightly less plaque than pipe/cigar smokers, and both smoker groups accumulated less plaque than nonsmokers. Gingival inflammation and tooth mobility did not differ between smokers and nonsmokers, nor between the two smoker groups. Cigarette smokers had significantly greater pocket depth than nonsmokers, in contrast to pipe/cigar smokers who were not different from nonsmokers. Radiographic measurements indicated that cigarette smokers had significantly more alveolar bone loss than either pipe/cigar or nonsmokers. After covariance adjustment for age and calculus, all smokers had less plaque, gingival inflammation and tooth mobility than nonsmokers, similar periodontal pocket depth, but only cigarette smokers had greater bone loss. This finding of greater alveolar bone loss in cigarette smokers suggests a tobacco product-related effect in systemic physiologic action.
Descriptors
Adult, Age Factors, Dental Calculus/pathology, Humans, Male, Middle Aged, Periodontal Diseases/etiology/pathology, Periodontal Index, Plants, Toxic, Smoking, Time Factors, Tobacco
Links
Book Title
Database
Publisher
Data Source
Authors
Feldman,R. S., Bravacos,J. S., Rose,C. L.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Hot water systems as sources of Legionella pneumophila in hospital and nonhospital plumbing fixtures 1982
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Applied and Environmental Microbiology
Periodical, Abbrev.
Appl.Environ.Microbiol.
Pub Date Free Form
May
Volume
43
Issue
5
Start Page
1104
Other Pages
1110
Notes
LR: 20130924; GR: AI 17047/AI/NIAID NIH HHS/United States; JID: 7605801; OID: NLM: PMC244193; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0099-2240; 0099-2240
Accession Number
PMID: 7103477
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; IM
DOI
Output Language
Unknown(0)
PMID
7103477
Abstract
Samples obtained from plumbing systems of hospitals, nonhospital institutions and homes were cultured for Legionella spp. by plating the samples directly on a selective medium. Swab samples were taken from the inner surfaces of faucet assemblies (aerators, spouts, and valve seats), showerheads, and shower pipes. Water and sediment were collected from the bottom of hot-water tanks. Legionella pneumophila serogroups 1, 5, and 6 were recovered from plumbing fixtures of the hospitals and nonhospital institutions and one of five homes. The legionellae (7 to 13,850 colony-forming units per ml) were also present in water and sediment from hot-water tanks maintained at 30 to 54 degrees C, but not in those maintained at 71 and 77 degrees C. Legionella micdadei was isolated from one tank. Thus legionellae are present in hot-water tanks which are maintained at warm temperatures or whose design results in warm temperatures at the bottom of the tanks. We hypothesize that hot-water tanks are a breeding site and a major source of L. pneumophila for the contamination of plumbing systems. The existence of these bacteria in the plumbing systems and tanks was not necessarily associated with disease. The extent of the hazard of this contamination needs to be delineated.
Descriptors
Equipment and Supplies, Hospital, Hot Temperature, Legionella/growth & development/isolation & purification, Sanitary Engineering/instrumentation, Water Microbiology, Water Supply
Links
Book Title
Database
Publisher
Data Source
Authors
Wadowsky,R. M., Yee,R. B., Mezmar,L., Wing,E. J., Dowling,J. N.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC244193
Editors
Benzene emissions in the neighbourhood of filling stations 1995 Gesundheitsamt der Stadt Frankfurt am Main.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine
Periodical, Abbrev.
Zentralbl.Hyg.Umweltmed.
Pub Date Free Form
Jan
Volume
196
Issue
5
Start Page
416
Other Pages
424
Notes
LR: 20131121; JID: 8912563; 0 (Air Pollutants); 0 (Benzene Derivatives); 0 (Carcinogens); 0 (Vehicle Emissions); 0 (Xylenes); 3FPU23BG52 (Toluene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene); ppublish
Place of Publication
GERMANY
ISSN/ISBN
0934-8859; 0934-8859
Accession Number
PMID: 7537043
Language
ger
SubFile
Comparative Study; English Abstract; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
7537043
Abstract
BTXE-Immissions (benzene, toluene, ethylbenzene, xylene) were measured in 32 flats in the neighbourhood of 12 filling stations in Frankfurt on the Main. Mean benzene-concentration in the indoor air nearby filling stations was 10.2 micrograms/m3, whereas in reference flats 5.6 micrograms/m3 were measured. Maximum levels were 22.4 micrograms/m3 and 8.0 micrograms/m3. Indoor air levels were slightly higher than outdoor air contaminations. High Toluene-concentrations were not caused by the filling stations but by other commercial enterprises, such as paint shops. Mean ethylbenzene or xylene-concentrations in the neighbourhood of filling stations did not differ from the concentrations measured in the reference flats. Because of the cancerogenicity of benzene the benzene-contaminations in the neighbourhood of filling stations have to be lowered. The newly established German law to prevent gas leakage in filling stations will lead to some improvement in the future.
Descriptors
Air Pollutants/analysis, Benzene/analysis, Benzene Derivatives/analysis, Carcinogens/analysis, Germany, Humans, Toluene/analysis, Urban Health, Vehicle Emissions, Xylenes/analysis
Links
Book Title
Database
Publisher
Data Source
Authors
Heudorf,U., Hentschel,W.
Original/Translated Title
Benzol-Immissionen in Wohnungen im Umfeld von Tankstellen
URL
Date of Electronic
PMCID
Editors
Varying nicotine patch dose and type of smoking cessation counseling 1995 Center for Tobacco Research and Intervention, University of Wisconsin-Madison, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Jama
Periodical, Abbrev.
JAMA
Pub Date Free Form
1-Nov
Volume
274
Issue
17
Start Page
1347
Other Pages
1352
Notes
LR: 20151119; JID: 7501160; 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); K5161X06LL (Cotinine); CIN: JAMA. 1996 Jun 26;275(24):1882-3. PMID: 8648863; CIN: JAMA. 1995 Nov 1;274(17):1390-1. PMID: 7563566; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0098-7484; 0098-7484
Accession Number
PMID: 7563558
Language
eng
SubFile
Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; AIM; IM
DOI
Output Language
Unknown(0)
PMID
7563558
Abstract
OBJECTIVE: To compare the efficacy and safety of 22-mg and 44-mg doses of transdermal nicotine therapy when it is paired with minimal, individual, or group counseling to improve smoking cessation rates. DESIGN: An 8-week clinical trial (4 weeks double-blind followed by 4 weeks open label) using random assignment of participants to both dose (22 or 44 mg) and counseling (minimal, individual, or group) conditions. PARTICIPANTS: Daily cigarette smokers (> or = 15 cigarettes per day for at least 1 year) who volunteered to participate in a study of smoking cessation treatment. A total of 504 participants were enrolled at two sites. INTERVENTION: Four weeks of 22- or 44-mg transdermal nicotine therapy followed by 4 weeks of dosage reduction (2 weeks of 22 mg followed by 2 weeks of 11 mg). Counseling consisted of a self-help pamphlet (minimal); a self-help pamphlet, a brief physician motivational message, and three brief (< 15 minutes) follow-up visits with a nurse (individual); or the pamphlet, the motivational message, and eight weekly 1-hour group smoking cessation counseling visits (group). All participants returned weekly to turn in questionnaires and for assessment of their smoking status. MAIN OUTCOME MEASURES: Abstinence from smoking was based on self-report, confirmed by an expired carbon monoxide concentration lower than 10 ppm. Withdrawal severity was assessed by means of an eight-item self-report questionnaire completed daily. RESULTS: Smoking cessation rates for the two nicotine patch doses and three levels of counseling did not differ significantly at either 8 weeks or 26 weeks following the quit date. Among those receiving minimal contact, the 44-mg dose produced greater abstinence at 4 weeks than did the 22-mg dose (68% vs 45%; P < .01). Participants receiving minimal-contact adjuvant treatment were less likely to be abstinent at the end of 4 weeks than those receiving individual or group counseling (56% vs 67%; P < .05). The 44-mg dose decreased desire to smoke more than the 22-mg dose, but this effect was not related to success in quitting smoking. Transdermal nicotine therapy at doses of 44 mg produced a significantly greater frequency of nausea (28%), vomiting (10%), and erythema with edema at the patch site (30%) than did a 22-mg dose (10%, 2%, and 13%, respectively; P < .01 for each adverse effect). Three serious adverse events occurred during use of the 44-mg patch dose. CONCLUSIONS: There does not appear to be any general, sustained benefit of initiating transdermal nicotine therapy with a 44-mg patch dose or of providing intense adjuvant smoking cessation treatment. The two doses and all adjuvant treatments produced equivalent effects at the 26-week follow-up, and the higher patch dose produced more adverse effects. Higher-dose (44-mg) nicotine replacement does not appear to be indicated for general clinical populations, although it may provide short-term benefit to some smokers attempting to quit with minimal adjuvant treatment.
Descriptors
Administration, Cutaneous, Adult, Analysis of Variance, Carbon Monoxide/metabolism, Combined Modality Therapy, Cotinine/blood, Counseling, Double-Blind Method, Female, Humans, Logistic Models, Male, Middle Aged, Nicotine/administration & dosage/therapeutic use, Smoking Cessation/methods, Substance Withdrawal Syndrome
Links
Book Title
Database
Publisher
Data Source
Authors
Jorenby,D. E., Smith,S. S., Fiore,M. C., Hurt,R. D., Offord,K. P., Croghan,I. T., Hays,J. T., Lewis,S. F., Baker,T. B.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Respiratory symptoms and environmental factors in schoolchildren in the Bay of Plenty 1995 Eastbay Health, Whakatane.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The New Zealand medical journal
Periodical, Abbrev.
N.Z.Med.J.
Pub Date Free Form
8-Sep
Volume
108
Issue
1007
Start Page
358
Other Pages
361
Notes
LR: 20151119; JID: 0401067; 0 (Air Pollutants); 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
NEW ZEALAND
ISSN/ISBN
0028-8446; 0028-8446
Accession Number
PMID: 7566773
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
7566773
Abstract
AIMS: To determine the prevalence of respiratory symptoms in children and to examine associations with environmental factors in the Bay of Plenty. METHODS: International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires were distributed to 13-14 year old children and to care-givers of 6-7 year old children as part of the ISAAC study. RESULTS: Completed questionnaires were received for 2614 primary and 2752 secondary students. Analysis by district showed no consistent association with exposure to industrial emissions from paper mills, natural sulphur fumes, or climatic variation. All districts are subject to high levels of pollen. Symptom prevalence was close to the mean for New Zealand centres participating in the ISAAC survey. Night cough and nasal symptoms were more common in secondary pupils exposed to smoking in the home, but there was no consistent association between passive smoking and wheeze or diagnosed asthma. Children from larger households reported less wheezy symptoms and less diagnosed asthma. CONCLUSIONS: There was no consistent evidence of an effect on respiratory morbidity from natural fumes, industrial air pollution, or climate. The indoor environment is probably of greater importance in this population.
Descriptors
Adolescent, Air Pollutants/adverse effects, Asthma/epidemiology/etiology, Child, Cough/epidemiology/etiology, Data Collection, Europe/ethnology, Humans, New Zealand/epidemiology, Prevalence, Respiratory Sounds/etiology, Respiratory Tract Diseases/epidemiology/etiology, Rhinitis/epidemiology/etiology, Surveys and Questionnaires, Tobacco Smoke Pollution/adverse effects
Links
Book Title
Database
Publisher
Data Source
Authors
Moyes,C. D., Waldon,J., Ramadas,D., Crane,J., Pearce,N.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors