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Alveolar bone loss and tooth loss in male cigar and pipe smokers 1999 VA Outpatient Clinic, Boston, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of the American Dental Association (1939)
Periodical, Abbrev.
J.Am.Dent.Assoc.
Pub Date Free Form
Jan
Volume
130
Issue
1
Start Page
57
Other Pages
64
Notes
LR: 20071114; GR: DA 10073/DA/NIDA NIH HHS/United States; JID: 7503060; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0002-8177; 0002-8177
Accession Number
PMID: 9919032
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; D; IM
DOI
S0002-8177(14)65673-7 [pii]
Output Language
Unknown(0)
PMID
9919032
Abstract
BACKGROUND: While cigarette smoking is recognized as being detrimental to oral health, the effects of cigar and pipe smoking on tooth-loss risk, alveolar bone loss and periodontal disease are not known. The authors conducted this study to determine whether cigar and pipe smokers were at greater risk of experiencing tooth loss and alveolar bone loss than were nonsmokers. METHODS: The authors studied 690 dentate men who participate in the Veterans Affairs Dental Longitudinal Study. Subjects are not VA patients, and they receive medical and dental care in the private sector. A board-certified periodontist conducted clinical examinations triennially for 23 years. These examinations included the number of teeth remaining, number of decayed and filled surfaces per tooth, and indicator scores for plaque, calculus, pocket probing depth, gingival bleeding and tooth mobility. Alveolar bone loss was assessed at each examination on intraoral periapical radiographs using the Schei ruler method, which measures loss of bone height in 20 percent increments. Multivariate analyses of tooth-loss rates and alveolar bone loss controlled for demographic and oral hygiene measures. RESULTS: The relative risk, or RR, of tooth loss compared with that of nonsmokers was significantly elevated in cigar smokers (RR = 1.3, 95 percent confidence interval, or CI, = 1.2, 1.5), pipe smokers (RR = 1.6, 95 percent CI = 1.4, 1.9) and cigarette smokers (RR = 1.6, 95 percent CI = 1.5, 1.7). The percentages of mesial and distal sites with moderate-to-severe progression of alveolar bone loss (a change of 40 percent or more from baseline) were 8 +/- 1 percent (mean +/- standard error) in nonsmokers, 16 +/- 3 percent in cigar smokers (P < .05), 13 +/- 4 percent in pipe smokers (P = .17), and 16 +/- 3 percent in cigarette smokers (P < .001). Pipe and cigar smokers did not differ significantly from nonsmokers with respect to the percentage of sites at baseline with moderate-to-severe scores for calculus, pocket probing depth, gingival bleeding or tooth mobility. Pipe smokers had fewer sites with moderate-to-severe plaque accumulation than did nonsmokers (7 +/- 11 vs. 13 +/- 17, P < .05). CONCLUSIONS: The authors found that men who smoke cigars or pipes were at increased risk of experiencing tooth loss. Cigar smokers also were at increased risk of experiencing alveolar bone loss. These elevations in risk are similar in magnitude to those observed in cigarette smokers. CLINICAL IMPLICATIONS: The increases in risk related to cigar and pipe smoking provide a strong rationale for targeting smoking prevention and smoking cessation programs to smokers of all tobacco products.
Descriptors
Adult, Aged, Alveolar Bone Loss/etiology, Confidence Intervals, DMF Index, Demography, Dental Calculus/etiology, Dental Plaque Index, Disease Progression, Gingival Hemorrhage/etiology, Humans, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Oral Hygiene, Periodontal Diseases/etiology, Periodontal Pocket/etiology, Risk Factors, Smoking/adverse effects, Tooth Loss/etiology, Tooth Mobility/etiology
Links
Book Title
Database
Publisher
Data Source
Authors
Krall,E. A., Garvey,A. J., Garcia,R. I.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Equipment for testing the water-tightness of drinking water pipe joints in relation to the new requirements of installation and repair of pipes damaged by war.; Attrezzature per la prova ed il controllo di tenuta dei giunti delle condutture per acque pota 1951 Vacino, E.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Rendiconti - Istituto superiore di sanità
Periodical, Abbrev.
Rend Ist Sup Sanit
Pub Date Free Form
/
Volume
14
Issue
1
Start Page
5
Other Pages
18
Notes
Place of Publication
ISSN/ISBN
0370-5811
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
article, PLUMBING, sanitation
Links
Book Title
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Vacino,E.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
PVC-H used for waste water pipes 1979 VEB Kombinat Tiefbau, Berlin
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Wasserwirtschaft Wassertechnik
Periodical, Abbrev.
WASSERWIRTSCH.WASSERTECHN.
Pub Date Free Form
1979/
Volume
29
Issue
10
Start Page
332
Other Pages
333
Notes
Place of Publication
ISSN/ISBN
0043-0986
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
plastic, methodology, pipeline, therapy, waste water management
Links
Book Title
SYSTEMLOSUNG PVC-H ABWASSERNETZE. ANWENDUNGSSTAND UND ERFAHRUNGEN
Database
Embase
Publisher
Data Source
Embase
Authors
Albert,J., Pfaff,D.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Removal of MS2, Qbeta and GA bacteriophages during drinking water treatment at pilot scale 2012 Veolia Environment Research and Innovation, Chemin de la Digue, BP76, 78608 Maisons-Laffitte Cedex, France. nicolas.boudaud@veolia.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Water research
Periodical, Abbrev.
Water Res.
Pub Date Free Form
15-May
Volume
46
Issue
8
Start Page
2651
Other Pages
2664
Notes
LR: 20131121; CI: Copyright (c) 2012; JID: 0105072; 0 (Drinking Water); 0 (Membranes, Artificial); 0 (Solutions); 4R7X1O2820 (Chlorine); 2011/03/01 [received]; 2012/01/27 [revised]; 2012/02/11 [accepted]; 2012/03/03 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1879-2448; 0043-1354
Accession Number
PMID: 22421032
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.watres.2012.02.020 [doi]
Output Language
Unknown(0)
PMID
22421032
Abstract
The removal of MS2, Qbeta and GA, F-specific RNA bacteriophages, potential surrogates for pathogenic waterborne viruses, was investigated during a conventional drinking water treatment at pilot scale by using river water, artificially and independently spiked with these bacteriophages. The objective of this work is to develop a standard system for assessing the effectiveness of drinking water plants with respect to the removal of MS2, Qbeta and GA bacteriophages by a conventional pre-treatment process (coagulation-flocculation-settling-sand filtration) followed or not by an ultrafiltration (UF) membrane (complete treatment process). The specific performances of three UF membranes alone were assessed by using (i) pre-treated water and (ii) 0.1 mM sterile phosphate buffer solution (PBS), spiked with bacteriophages. These UF membranes tested in this work were designed for drinking water treatment market and were also selected for research purpose. The hypothesis serving as base for this study was that the interfacial properties for these three bacteriophages, in terms of electrostatic charge and the degree of hydrophobicity, could induce variations in the removal performances achieved by drinking water treatments. The comparison of the results showed a similar behaviour for both MS2 and Qbeta surrogates whereas it was particularly atypical for the GA surrogate. The infectious character of MS2 and Qbeta bacteriophages was mostly removed after clarification followed by sand filtration processes (more than a 4.8-log reduction) while genomic copies were removed at more than a 4.0-log after the complete treatment process. On the contrary, GA bacteriophage was only slightly removed by clarification followed by sand filtration, with less than 1.7-log and 1.2-log reduction, respectively. After the complete treatment process achieved, GA bacteriophage was removed with less than 2.2-log and 1.6-log reduction, respectively. The effectiveness of the three UF membranes tested in terms of bacteriophages removal showed significant differences, especially for GA bacteriophage. These results could provide recommendations for drinking water suppliers in terms of selection criteria for membranes. MS2 bacteriophage is widely used as a surrogate for pathogenic waterborne viruses in Europe and the United States. In this study, the choice of MS2 bacteriophage as the best surrogate to be used for assessment of the effectiveness of drinking water treatment in removal of pathogenic waterborne viruses in worst conditions is clearly challenged. It was shown that GA bacteriophage is potentially a better surrogate as a worst case than MS2. Considering GA bacteriophage as the best surrogate in this study, a chlorine disinfection step could guaranteed a complete removal of this model and ensure the safety character of drinking water plants.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Boudaud,N., Machinal,C., David,F., Freval-Le Bourdonnec,A., Jossent,J., Bakanga,F., Arnal,C., Jaffrezic,M.P., Oberti,S., Gantzer,C.
Original/Translated Title
URL
Date of Electronic
20120303
PMCID
Editors
Examining vulnerability to smokeless tobacco use among adolescents and adults meeting diagnostic criteria for major depressive disorder 2014 Vermont Center on Behavior and Health and Department of Psychiatry, University of Vermont.; Vermont Center on Behavior and Health and Department of Psychiatry, University of Vermont.; Department of Psychiatry and Department of Psychology, University of Ve
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Experimental and clinical psychopharmacology
Periodical, Abbrev.
Exp.Clin.Psychopharmacol.
Pub Date Free Form
Aug
Volume
22
Issue
4
Start Page
316
Other Pages
322
Notes
LR: 20150805; GR: K01TW008410/TW/FIC NIH HHS/United States; GR: P20 GM103644/GM/NIGMS NIH HHS/United States; GR: P20GM103644/GM/NIGMS NIH HHS/United States; GR: P50 DA036114/DA/NIDA NIH HHS/United States; GR: P50DA036114/DA/NIDA NIH HHS/United States; GR:
Place of Publication
United States
ISSN/ISBN
1936-2293; 1064-1297
Accession Number
PMID: 24978349
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; IM
DOI
10.1037/a0037291 [doi]
Output Language
Unknown(0)
PMID
24978349
Abstract
Smoking prevalence is unevenly distributed in the U.S. population, with those with mental illness, other substance use disorders, and lower socioeconomic status being especially vulnerable. Less research has been conducted on the association between these same vulnerabilities and smokeless tobacco (ST) use. The present study examined cigarette and ST use among adolescents and adults who met diagnostic criteria for major depressive disorder in the National Survey on Drug Use and Health (NSDUH). Utilizing the most recent (2011) NSDUH, we compared odds for current cigarette smoking and ST use among adolescents and adults meeting criteria for past-year major depressive disorder to the general population, after adjusting for potential confounding influences of sociodemographic and other substance use characteristics. Analyses were conducted to examine sex as a moderator of the relation between major depressive disorder and tobacco use. Odds for current cigarette smoking among those classified with major depressive disorder were increased among adolescents (OR = 1.33, 95% CI [1.05, 1.69], p = .021) and adults (OR = 1.70, 95% CI [1.47, 1.97], p
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Redner,R., White,T.J., Harder,V.S., Higgins,S.T.
Original/Translated Title
URL
Date of Electronic
20140630
PMCID
PMC4124457
Editors
E-cigarette use among women of reproductive age: Impulsivity, cigarette smoking status, and other risk factors 2016 Vermont Center on Behavior and Health, University of Vermont, United States; Department of Psychiatry, University of Vermont, United States; Department of Psychology, University of Vermont, United States; Department of Psychology, Harvard University, Unit
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Preventive medicine
Periodical, Abbrev.
Prev.Med.
Pub Date Free Form
1-Aug
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160805; CI: Copyright (c) 2016; JID: 0322116; OTO: NOTNLM; 2015/12/14 [received]; 2016/07/23 [revised]; 2016/07/31 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1096-0260; 0091-7435
Accession Number
PMID: 27492277
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S0091-7435(16)30206-7 [pii]
Output Language
Unknown(0)
PMID
27492277
Abstract
INTRODUCTION: The study aim was to examine impulsivity and other risk factors for e-cigarette use among women of reproductive age comparing current daily cigarette smokers to never cigarette smokers.Women of reproductive age are of special interest because of the additional risk that tobacco and nicotine use represents should they become pregnant. METHOD: Survey data were collected anonymously online using Amazon Mechanical Turk in 2014.Participants were 800 women ages 24-44years from the US.Half (n=400) reported current, daily smoking and half (n=400) reported smoking
Descriptors
Links
Book Title
Database
Publisher
. Published by Elsevier Inc
Data Source
Authors
Chivers,L.L., Hand,D.J., Priest,J.S., Higgins,S.T.
Original/Translated Title
URL
Date of Electronic
20160801
PMCID
Editors
Long bone histology of the stem salamander Kokartus honorarius (Amphibia: Caudata) from the Middle Jurassic of Kyrgyzstan 2015 Vertebrate Zoology Department, Biological Faculty, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of anatomy
Periodical, Abbrev.
J.Anat.
Pub Date Free Form
Apr
Volume
226
Issue
4
Start Page
334
Other Pages
347
Notes
CI: (c) 2015; JID: 0137162; OTO: NOTNLM; 2015/01/05 [accepted]; 2015/02/12 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-7580; 0021-8782
Accession Number
PMID: 25682890
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1111/joa.12281 [doi]
Output Language
Unknown(0)
PMID
25682890
Abstract
Kokartus honorarius from the Middle Jurassic (Bathonian) of Kyrgyzstan is one of the oldest salamanders in the fossil record, characterized by a mixture of plesiomorphic morphological features and characters shared with crown-group salamanders. Here we present a detailed histological analysis of its long bones. The analysis of a growth series demonstrates a significant histological maturation during ontogeny, expressed by the progressive appearance of longitudinally oriented primary vascular canals, primary osteons, growth marks, remodelling features in primary bone tissues, as well as progressive resorption of the calcified cartilage, formation of endochondral bone and development of cartilaginous to bony trabeculae in the epiphyses. Apart from the presence of secondary osteons, the long bone histology of Kokartus is very similar to that of miniaturized temnospondyls, other Jurassic stem salamanders, miniaturized seymouriamorphs and modern crown-group salamanders. We propose that the presence of secondary osteons in Kokartus honorarius is a plesiomorphic feature, and the loss of secondary osteons in the long bones of crown-group salamanders as well as in those of miniaturized temnospondyls is the result of miniaturization processes. Hitherto, all stem salamander long bong histology (Kokartus, Marmorerpeton and 'salamander A') has been generally described as having paedomorphic features (i.e. the presence of Katschenko's Line and a layer of calcified cartilage), these taxa were thus most likely neotenic forms. The absence of clear lines of arrested growth and annuli in long bones of Kokartus honorarius suggests that the animals lived in an environment with stable local conditions.
Descriptors
Links
Book Title
Database
Publisher
Anatomical Society
Data Source
Authors
Skutschas,P., Stein,K.
Original/Translated Title
URL
Date of Electronic
20150212
PMCID
Editors
Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett&#39;s esophagus, Barrett&#39;s dysplasia, and Barrett&#39;s adenocarcinoma 2000 Veterans Administration Medical Center, Kansas City, Missouri, 64128, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The American Journal of Gastroenterology
Periodical, Abbrev.
Am.J.Gastroenterol.
Pub Date Free Form
Feb
Volume
95
Issue
2
Start Page
387
Other Pages
394
Notes
LR: 20131121; JID: 0421030; 0 (Coloring Agents); 0 (Enzyme Inhibitors); 0 (Proton Pump Inhibitors); ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0002-9270; 0002-9270
Accession Number
PMID: 10685740
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
S0002-9270(99)00817-5 [pii]
Output Language
Unknown(0)
PMID
10685740
Abstract
OBJECTIVE: This study was undertaken to prospectively determine the prevalence of gastric H. pylori infection in Barrett's esophagus and Barrett's complicated by dysplasia or adenocarcinoma. METHODS: The prevalence of H. pylori was determined in Barrett's esophagus patients compared to a control population of patients with gastroesophageal reflux disease (GERD) only. All patients had a minimum of 10 gastric surveillance biopsies obtained. H. pylori colonization was determined upon the basis of hematoxylin and eosin and use of a modified Giemsa and or Steiner's silver stain of all gastric biopsy specimens. RESULTS: Two hundred and eighty-nine Barrett's patients and 217 GERD control patients were included in the study. H. pylori was found in 95/289 (32.9%) of the Barrett's patients, compared with 96/217 (44.2%) of the GERD controls (NS). Forty-seven of the Barrett's patients had low-grade dysplasia/indefinite dysplasia, 14 high-grade dysplasia, and 20 Barrett's adenocarcinoma. When Barrett's was subgrouped according to absence of dysplasia, and presence of low-grade dysplasia, high-grade dysplasia, or adenocarcinoma, H. pylori prevalence was found to be significantly less for patients with Barrett's high-grade dysplasia (14.3%) and adenocarcinoma (15.0%) versus patients with GERD alone (44.2%), Barrett's alone (35.1%), or Barrett's with low-grade dysplasia (36.2%) (p = 0.016). This difference could not be explained by differences between Barrett's esophagus patients infected with H. pylori and those who were not with respect to gender, smoking history, alcohol consumption, use of proton pump inhibitor, or length of Barrett's mucosa. CONCLUSIONS: Barrett's high-grade dysplasia and adenocarcinoma are significantly more prevalent in patients who are not infected with H. pylori. H. pylori appears to have a protective effect against the development of Barrett's adenocarcinoma.
Descriptors
Adenocarcinoma/epidemiology/microbiology, Alcohol Drinking/epidemiology, Analysis of Variance, Barrett Esophagus/epidemiology/microbiology/pathology, Biopsy, Chi-Square Distribution, Coloring Agents, Enzyme Inhibitors/therapeutic use, Esophageal Neoplasms/epidemiology/microbiology, Esophagoscopy, Female, Follow-Up Studies, Gastroesophageal Reflux/drug therapy/epidemiology/microbiology, Helicobacter Infections/epidemiology, Helicobacter pylori/growth & development, Humans, Kansas/epidemiology, Male, Middle Aged, Prevalence, Prospective Studies, Proton Pump Inhibitors, Smoking/epidemiology, Stomach Diseases/epidemiology/microbiology
Links
Book Title
Database
Publisher
Data Source
Authors
Weston,A. P., Badr,A. S., Topalovski,M., Cherian,R., Dixon,A., Hassanein,R. S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Epidemiology of gastroesophageal reflux disease 2014 Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI, USA; Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: jhr@umich.edu.; Division of Gastroenterology, University of Michigan
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Gastroenterology clinics of North America
Periodical, Abbrev.
Gastroenterol.Clin.North Am.
Pub Date Free Form
Mar
Volume
43
Issue
1
Start Page
1
Other Pages
14
Notes
CI: Published by Elsevier Inc.; JID: 8706257; Adenocarcinoma Of Esophagus; OTO: NOTNLM; 2013/12/27 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1558-1942; 0889-8553
Accession Number
PMID: 24503355
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.1016/j.gtc.2013.11.006 [doi]
Output Language
Unknown(0)
PMID
24503355
Abstract
The prevalence of gastroesophageal reflux disease (GERD) symptoms increased approximately 50% until the mid-1990s, when it plateaued. The incidence of complications related to GERD including hospitalization, esophageal strictures, esophageal adenocarcinoma, and mortality also increased during that time period, but the increase in esophageal adenocarcinoma has since slowed, and the incidence of strictures has decreased since the mid-1990s. GERD is responsible for the greatest direct costs in the United States of any gastrointestinal disease, and most of those expenditures are for pharmacotherapy. Risk factors for GERD include obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Rubenstein,J.H., Chen,J.W.
Original/Translated Title
URL
Date of Electronic
20131227
PMCID
Editors
Distribution system water age can create premise plumbing corrosion hotspots 2015 Via Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA, 24061, USA, smasters@vt.edu.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environmental monitoring and assessment
Periodical, Abbrev.
Environ.Monit.Assess.
Pub Date Free Form
Sep
Volume
187
Issue
9
Start Page
559
Other Pages
015-4747-4. Epub 2015 Aug 7
Notes
JID: 8508350; 0 (Drinking Water); 0 (Water Pollutants, Chemical); 12597-71-6 (brass); 2P299V784P (Lead); 789U1901C5 (Copper); J41CSQ7QDS (Zinc); 2015/01/12 [received]; 2015/07/14 [accepted]; 2015/08/07 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1573-2959; 0167-6369
Accession Number
PMID: 26251058
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1007/s10661-015-4747-4 [doi]
Output Language
Unknown(0)
PMID
26251058
Abstract
Cumulative changes in chemical and biological properties associated with higher "water age" in distribution systems may impact water corrosivity and regulatory compliance with lead and copper action levels. The purpose of this study was to examine the effects of water age and chemistry on corrosivity of various downstream premise plumbing pipe materials and configurations using a combination of controlled laboratory studies and a field survey. Examination of lead pipe, copper pipe with lead solder, and leaded brass materials in a replicated lab rig simulating premise plumbing stagnation events indicated that lead or copper release could increase as much as approximately 440 % or decrease as much as 98 % relative to water treatment plant effluent. In field studies at five utilities, trends in lead and copper release were highly dependent on circumstance; for example, lead release increased with water age in 13 % of cases and decreased with water age in 33 % of conditions tested. Levels of copper in the distribution system were up to 50 % lower and as much as 30 % higher relative to levels at the treatment plant. In many cases, high-risks of elevated lead and copper did not co-occur, demonstrating that these contaminants will have to be sampled separately to identify "worst case" conditions for human exposure and monitoring.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Masters,S., Parks,J., Atassi,A., Edwards,M.A.
Original/Translated Title
URL
Date of Electronic
20150807
PMCID
Editors