WTS database

Title	Pub Year	Author Sort descending	SearchLink
Histoplasma capsulatum in planktonic and biofilm forms: in vitro susceptibility to amphotericin B, itraconazole and farnesol	2015	Specialized Medical Mycology Center (CEMM), Federal University of Ceara, Fortaleza, Ceara, Brazil Federal University of Ceara, Fortaleza, Ceara, Brazil brilhante@ufc.br.; Specialized Medical Mycology Center (CEMM), Federal University of Ceara, Fortaleza,	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of medical microbiology Periodical, Abbrev. J.Med.Microbiol. Pub Date Free Form Apr Volume 64 Issue Pt 4 Start Page 394 Other Pages 399 Notes CI: (c) 2015; JID: 0224131; 0 (Antifungal Agents); 304NUG5GF4 (Itraconazole); 4602-84-0 (Farnesol); 7XU7A7DROE (Amphotericin B); 2014/12/05 [received]; 2015/01/18 [accepted]; 2015/02/05 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1473-5644; 0022-2615 Accession Number PMID: 25657300 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1099/jmm.0.000030 [doi] Output Language Unknown(0) PMID 25657300 Abstract It is believed that most microbial infections are caused by pathogens organized in biofilms. Recently, it was shown that the dimorphic fungus Histoplasma capsulatum, estimated to be the most common cause of fungal respiratory diseases, is also able to form biofilm. Although the antifungal therapy commonly used is effective, refractory cases and recurrences have been reported. In the search for new compounds with antimicrobial activity, the sesquiterpene farnesol has gained prominence for its antifungal action. This study aimed to evaluate the in vitro susceptibility of H. capsulatum var. capsulatum to the antifungal agents itraconazole and amphotericin B, and farnesol alone and combined, as well as to determine the in vitro antifungal activity of these compounds against biofilms of this pathogen. The results show that farnesol has antifungal activity against H. capsulatum in the yeast and filamentous phases, with MIC values ranging from 0.0078 to 0.00312 microM. A synergistic effect (fractional inhibitory concentration index =0.5) between itraconazole and farnesol was found against 100 and 83.3 % of the isolates in yeast and mycelial forms, respectively, while synergism between amphotericin B and farnesol was only observed against 37.5 and 44.4 % of the isolates in yeast and filamentous forms, respectively. Afterwards, the antifungal drugs, itraconazole and amphotericin B, and farnesol alone, and the combination of itraconazole and farnesol, were tested against mature biofilms of H. capsulatum, through XTT (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazoliu m hydroxide) metabolic assay, and the itraconazole and amphotericin B showed lower antibiofilm activity when compared to farnesol alone and farnesol combined with itraconazole. In conclusion, farnesol showed promising results as an antifungal agent against H. capsulatum and also showed adjuvant action, especially when combined with itraconazole, increasing the fungal susceptibility to this drug. Descriptors Links Book Title Database Publisher The Authors Data Source Authors Brilhante,R.S., de Lima,R.A., Marques,F.J., Silva,N.F., Caetano,E.P., Castelo-Branco Dde,S., Bandeira Tde,J., Moreira,J.L., Cordeiro Rde,A., Monteiro,A.J., Pires de Camargo,Z., Sidrim,J.J., Rocha,M.F. Original/Translated Title URL Date of Electronic 20150205 PMCID Editors
Severe carbon monoxide poisoning from waterpipe smoking: a public health concern	2015	St Vincent's Hospital, Sydney, NSW, Australia. louis.wang@unsw.edu.au.; Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; St Vincent's Hospital, Sydney, NSW, Australia.; St Vincent's Hospital, Sydney, NSW, Australia.; St	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Medical journal of Australia Periodical, Abbrev. Med.J.Aust. Pub Date Free Form 4-May Volume 202 Issue 8 Start Page 446 Other Pages 447 Notes JID: 0400714; 2014/09/06 [received]; 2014/11/11 [accepted]; ppublish Place of Publication Australia ISSN/ISBN 1326-5377; 0025-729X Accession Number PMID: 25929510 Language eng SubFile Case Reports; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.5694/mja14.01264 [pii] Output Language Unknown(0) PMID 25929510 Abstract Descriptors Links Book Title Database Publisher Data Source Authors Wang,L.W., He,E.Y., Ghosh,D., Day,R.O., Jones,G.R., Subbiah,R.N., Holloway,C.J. Original/Translated Title URL Date of Electronic PMCID Editors
Etiology of drug abuse: a narrative analysis	2014	St. Vincent Hospital, St. Vincent Health, Melbourne, Australia.; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of addiction Periodical, Abbrev. J.Addict. Pub Date Free Form Volume 2014 Issue Start Page 352835 Other Pages Notes LR: 20140925; JID: 101602563; OID: NLM: PMC4160618; 2014/05/05 [received]; 2014/08/18 [revised]; 2014/08/19 [accepted]; 2014/08/26 [epublish]; ppublish Place of Publication Egypt ISSN/ISBN 2090-7834; 2090-7850 Accession Number PMID: 25247105 Language eng SubFile Journal Article DOI 10.1155/2014/352835 [doi] Output Language Unknown(0) PMID 25247105 Abstract Introduction and Aim. Further gains in the prevention of drug abuse disorders require in-depth and holistic understanding of the risk factors of addiction from different perspectives. Lay persons and experts have different concepts of risk which could complement each other. The purpose of this study was to elaborate drug abuse risk factors through the story of individuals who had become drug dependent. Design and Methods. In this qualitative research, 33 individuals attending treatment centres for drug abuse were interviewed about the story of their addiction in Kerman, Iran. Interview questions were around the story of the participants. Results. All participants were male and in the age range of 18-40 years. Narrative analysis identified five themes as the main risk factors: family factors, peer pressure, the effect of gateway drugs (especially waterpipe), individual characteristics, and the community factors. More emphasis was placed upon the role of family factors, peer influence, and gateway effect. Discussion and Conclusion. This study elicited information from drug dependent subjects regarding the risk factors of drug abuse. According to drug dependent individuals' views, more attention should be devoted to family and peer influences by policy makers, in developing culture-based preventive strategies. Descriptors Links Book Title Database Publisher Data Source Authors Jadidi,N., Nakhaee,N. Original/Translated Title URL Date of Electronic 20140826 PMCID PMC4160618 Editors
The occurrence of salmonellae in drinking water	1979	Staatl. Mediz. Untersuch. Amt, Braunschweig	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Zentralblatt fur Bakteriologie.Hygiene.Krankenhaushygiene Betriebshygiene Praventive Medizin - Abt.1 Orig.B Periodical, Abbrev. ZENTRALBL.BAKT.HYG.KR.HYG.BETR.HYG.PRAV.MED.ABT.1 ORIG.B Pub Date Free Form 1979/ Volume 169 Issue 6-May Start Page 551 Other Pages 559 Notes Place of Publication ISSN/ISBN Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract A total of 7187 samples of drinking water from different areas of the Lower Saxonian District of Braunschweig was investigated during June 1977 and May 1979. The bacteriological results are given. Salmonellae were isolated in three samples of drinking water and in one sample of sludge from a municipal drinking water pipe. Additional experiments confirm that growth of salmonellae and other entereobacteria is possible in that sludge. These findings implicate some considerations: E. coli and coliforms are the most important microbial water quality indication. It is presupposed that, when the indicator density is low (less than 1 per 100 ml) the probability that pathogens are present also will be very low. But the question is how low? The risk factor may be estimated on the base of a E. coli-Salmonella ratio in raw sewage of about 106. But this ratio is already lessened in effluents of sewage treatment plants to 103 and often seems to be 102 in inadequately disinfected drinking water. For example, we have found four Salmonella and 408 E. coli serotypes over two years. Therefore, the judgement of the presence of E. coli or coliforms in samples of drinking water is important in this judgment of improvement of water quality by disinfection. Descriptors drinking water, geographic distribution, prevention, Salmonella, therapy Links Book Title UBER DAS VORKOMMEN VON SALMONELLEN IM TRINKWASSER Database Embase; MEDLINE Publisher Data Source Embase Authors Mueller,H. E. Original/Translated Title URL Date of Electronic PMCID Editors
Knowledge About E-Cigarette Constituents and Regulation: Results From a National Survey of U.S. Young Adults	2015	Stanford Prevention Research Center, School of Medicine, Stanford University, Palo Alto, CA; asnsande@stanford.edu.; Center of Excellence in Cancer Communication Research, Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA;;	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Oct Volume 17 Issue 10 Start Page 1247 Other Pages 1254 Notes LR: 20151006; CI: (c) The Author 2014; GR: P20CA095856/CA/NCI NIH HHS/United States; GR: R01 CA067850/CA/NCI NIH HHS/United States; GR: R01-CA067850/CA/NCI NIH HHS/United States; GR: T32 HL007034/HL/NHLBI NIH HHS/United States; GR: T32-HL007034/HL/NHLBI N Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 25542915 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1093/ntr/ntu276 [doi] Output Language Unknown(0) PMID 25542915 Abstract OBJECTIVES: To examine young adults' knowledge of e-cigarette constituents and regulation and its association with product use and self-reported exposure to marketing. METHODS: Young adults (18-34 years, N = 1,247) from a U.S. web panel were surveyed in March 2014. Using multinomial logistic regressions, self-reported exposure to marketing was examined as a predictor of whether participants responded correctly (reference category), incorrectly, or "don't know" to four knowledge items-whether e-cigarettes contain nicotine, contain toxic chemicals, are regulated by government for safety, and are regulated for use as a cessation aid. Analyses adjusted for demographics and smoking status and were weighted to match the U.S. young adult population. RESULTS: Most respondents did not know if e-cigarettes, contain toxic chemicals (48%), are regulated for safety (61%), and are regulated as cessation aids (68%); fewer than 37% answered all of these items correctly. Current users of e-cigarettes (past 30 days) had a lower likelihood of being incorrect about safety testing (p = .006) and being regulated as a cessation aid (p = .017). Higher exposure to e-cigarette marketing was associated with a lower likelihood of responding "don't know" than being correct, and with a higher likelihood of being incorrect as opposed to correct about e-cigarettes containing nicotine. CONCLUSIONS: Knowledge about e-cigarette constituents and regulation was low among young adults, who are the largest consumer group for these products. Interventions, such as warning labels or information campaigns, may be necessary to educate and correct misinformation about these products. Descriptors Links Book Title Database Publisher . Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco Data Source Authors Sanders-Jackson,A.N., Tan,A.S., Bigman,C.A., Henriksen,L. Original/Translated Title URL Date of Electronic 20141226 PMCID PMC4592338 Editors
Racial differences in cigarette brand recognition and impact on youth smoking	2013	Stanford Prevention Research Center, Stanford University School of Medicine, 1070 Arastradero Road, Suite 300, Palo Alto, CA 94304, USA. Adauph@stanford.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 25-Feb Volume 13 Issue Start Page 170 Other Pages 2458-13-170 Notes LR: 20150424; GR: CA-067850/CA/NCI NIH HHS/United States; GR: R01 CA067850/CA/NCI NIH HHS/United States; JID: 100968562; OID: NLM: PMC3586353; 2012/04/02 [received]; 2013/02/12 [accepted]; 2013/02/25 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 23442215 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1186/1471-2458-13-170 [doi] Output Language Unknown(0) PMID 23442215 Abstract BACKGROUND: African Americans are disproportionately exposed to cigarette advertisements, particularly for menthol brands. Tobacco industry documents outline strategic efforts to promote menthol cigarettes to African Americans at the point of sale, and studies have observed more outdoor and retail menthol advertisements in neighborhoods with more African-American residents. Little research has been conducted to examine the effect of this target marketing on adolescents' recognition of cigarette brand advertising and on smoking uptake. To our knowledge, this is the first study to examine racial differences in brand recognition and to assess the prospective relationship between brand recognition and smoking uptake. METHODS: School-based surveys assessing tobacco use and environmental and social influences to smoke were administered to 6th through 9th graders (ages 11 to 15) in an urban and racially diverse California school district. The primary outcome for the cross-sectional analysis (n = 2,589) was brand recognition, measured by students' identification of masked tobacco advertisements from the point of sale. The primary outcome for the longitudinal analysis (n = 1,179) was progression from never to ever smoking within 12 months. RESULTS: At baseline, 52% of students recognized the Camel brand, 36% Marlboro, and 32% Newport. African-American students were three times more likely than others to recognize Newport (OR = 3.03, CI = 2.45, 3.74, p Descriptors Links Book Title Database Publisher Data Source Authors Dauphinee,A.L., Doxey,J.R., Schleicher,N.C., Fortmann,S.P., Henriksen,L. Original/Translated Title URL Date of Electronic 20130225 PMCID PMC3586353 Editors
Impact of disinfection on drinking water biofilm bacterial community	2015	State Environmental Protection Key Laboratory of Microorganism Application and Risk Control (MARC), Tsinghua University, Beijing 100084, China; School of Environment, Tsinghua University, Beijing 100084, China. Electronic address: mzl10@mails.tsinghua.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of Environmental Sciences (China) Periodical, Abbrev. J.Environ.Sci.(China) Pub Date Free Form 1-Nov Volume 37 Issue Start Page 200 Other Pages 205 Notes CI: Copyright (c) 2015; JID: 100967627; 0 (Chloramines); 0 (Disinfectants); 0 (Drinking Water); 10599-90-3 (chloramine); 4R7X1O2820 (Chlorine); OTO: NOTNLM; 2015/02/27 [received]; 2015/04/22 [revised]; 2015/04/23 [accepted]; 2015/06/26 [aheadofprint]; ppu Place of Publication Netherlands ISSN/ISBN 1001-0742; 1001-0742 Accession Number PMID: 26574105 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.jes.2015.04.008 [doi] Output Language Unknown(0) PMID 26574105 Abstract Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. The present study investigated the impacts of different disinfectants (chlorine and chloramine) and dosages on biofilm bacterial community in bench-scale pipe section reactors. Illumina MiSeq sequencing illustrated that disinfection strategy could affect both bacterial diversity and community structure of drinking water biofilm. Proteobacteria tended to predominate in chloraminated drinking water biofilms, while Firmicutes in chlorinated and unchlorinated biofilms. The major proteobacterial groups were influenced by both disinfectant type and dosage. In addition, chloramination had a more profound impact on bacterial community than chlorination. Descriptors Links Book Title Database Publisher . Published by Elsevier B.V Data Source Authors Mi,Z., Dai,Y., Xie,S., Chen,C., Zhang,X. Original/Translated Title URL Date of Electronic 20150626 PMCID Editors
Determination of hydroxy metabolites of polycyclic aromatic hydrocarbons by fully automated solid-phase microextraction derivatization and gas chromatography-mass spectrometry	2007	State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. cesltg@mail.sysu.edu.cn	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.A Periodical, Abbrev. J.Chromatogr.A Pub Date Free Form 30-Nov Volume 1173 Issue 2-Jan Start Page 37 Other Pages 43 Notes LR: 20101118; JID: 9318488; 0 (Polycyclic Hydrocarbons, Aromatic); 2007/08/08 [received]; 2007/10/12 [revised]; 2007/10/16 [accepted]; 2007/10/22 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 0021-9673; 0021-9673 Accession Number PMID: 17976631 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI S0021-9673(07)01783-9 [pii] Output Language Unknown(0) PMID 17976631 Abstract A fully automated sample pretreatment method was developed for the detection of mono and dihydroxy metabolites of polycyclic aromatic hydrocarbons (PAHs) by gas chromatography-mass spectrometry in the selected ion monitoring mode. Direct immersion solid-phase microextraction for the extraction of target compounds and the headspace on-fiber silylation with N,O-bis(trimethylsilyl)trifluoroacetamide were performed automatically by a multipurpose autosampler (MPS2). The operating conditions including extraction time, derivatization time, ionic strength, pH, and incubation temperature were optimized. Calibration responses of nine metabolites of PAHs over a concentration range of 0.1-100 microg L(-1) with a correlation coefficient of 0.999 were obtained. The detection limits of the nine metabolites in mini pore water, minimal salts medium and soil extract culture medium were in the range of 0.001-0.013, 0.002-0.024 and 0.002-0.134 microg L(-1), respectively, while the respective quantification limits were 0.003-0.044, 0.005-0.081 and 0.008-0.447 microg L(-1). The reliability was confirmed by the traditional solid-phase extraction method. The proposed method could be used to analyze the metabolites of PAHs degraded by microorganisms such as algae and to determine the biodegradation pathways of PAHs. Descriptors Biodegradation, Environmental, Chlorophyta/metabolism, Gas Chromatography-Mass Spectrometry/methods, Polycyclic Hydrocarbons, Aromatic/analysis/metabolism, Reproducibility of Results, Solid Phase Microextraction/methods Links Book Title Database Publisher Data Source Authors Luan,T., Fang,S., Zhong,Y., Lin,L., Chan,S. M., Lan,C., Tam,N. F. Original/Translated Title URL Date of Electronic 20071022 PMCID Editors
A specific pharmacophore model of Aurora B kinase inhibitors and virtual screening studies based on it	2009	State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Chemical biology & drug design Periodical, Abbrev. Chem.Biol.Drug Des. Pub Date Free Form Jan Volume 73 Issue 1 Start Page 115 Other Pages 126 Notes LR: 20131121; JID: 101262549; EC 2.7.11.1 (AURKB protein, human); EC 2.7.11.1 (Aurora Kinase B); EC 2.7.11.1 (Aurora Kinases); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); ppublish Place of Publication England ISSN/ISBN 1747-0285; 1747-0277 Accession Number PMID: 19152640 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1111/j.1747-0285.2008.00751.x [doi] Output Language Unknown(0) PMID 19152640 Abstract In this study, 3D-pharmacophore models of Aurora B kinase inhibitors have been developed by using HipHop and HypoGen modules in Catalyst software package. The best pharmacophore model, Hypo1, which has the highest correlation coefficient (0.9911), consists of one hydrogen-bond acceptor, one hydrogen-bond donor, one hydrophobic aliphatic moiety and one ring aromatic feature. Hypo1 was validated by test set and cross-validation methods. And the specificity of Hypo1 to Aurora B inhibitors was examined with the use of selective inhibitors against Aurora B and its paralogue Aurora A. The results clearly indicate that Hypo1 can differentiate selective inhibitors of Aurora B from those of Aurora A, and the ring aromatic feature likely plays some important roles for the specificity of Hypo1. Then Hypo1 was used as a 3D query to screen several databases including Specs, NCI, Maybridge and Chinese Nature Product Database (CNPD) for identifying new inhibitors of Aurora B. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking studies to refine the retrieved hits, and some compounds selected from the top ranked hits have been suggested for further experimental assay studies. Descriptors Aurora Kinase B, Aurora Kinases, Computer Simulation, Drug Design, Drug Evaluation, Preclinical/methods, Humans, Inhibitory Concentration 50, Models, Molecular, Molecular Structure, Protein-Serine-Threonine Kinases/antagonists & inhibitors/chemistry, Reproducibility of Results, Software, Structure-Activity Relationship Links Book Title Database Publisher Data Source Authors Wang,H. Y., Li,L. L., Cao,Z. X., Luo,S. D., Wei,Y. Q., Yang,S. Y. Original/Translated Title URL Date of Electronic PMCID Editors
Pharmacophore modeling and virtual screening studies of checkpoint kinase 1 inhibitors	2009	State Key Laboratory of Biotherapy, West China Hospital, West China School of Pharmacy, Sichuan University.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Chemical & pharmaceutical bulletin Periodical, Abbrev. Chem.Pharm.Bull.(Tokyo) Pub Date Free Form Jul Volume 57 Issue 7 Start Page 704 Other Pages 709 Notes LR: 20111102; JID: 0377775; 0 (Enzyme Inhibitors); EC 2.7.- (Protein Kinases); EC 2.7.11.1 (Checkpoint kinase 1); ppublish Place of Publication Japan ISSN/ISBN 0009-2363; 0009-2363 Accession Number PMID: 19571415 Language eng SubFile Journal Article; IM DOI JST.JSTAGE/cpb/57.704 [pii] Output Language Unknown(0) PMID 19571415 Abstract In this study, chemical feature-based 3-dimensional (3D) pharmacophore models of Checkpoint kinase 1 (Chk1) inhibitors were developed based on the known inhibitors of Chk1. The best pharmacophore model Hypo1 was characterized by the best correlation coefficient (0.9577), and the lowest root mean square deviation (0.8871). Hypo1 consists of one hydrogen-bond acceptor, one hydrogen-bond donor, and two hydrophobic features, as well as one excluded volume. This pharmacophore model was further validated by both test set and cross validation methods. A comparison analysis of Hypo1 with chemical features in the active site of Chk1 indicates that the pharmacophore model Hypo1 can correctly reflect the interactions between Chk1 and its ligands. Then Hypo1 was used to screen chemical databases, including Specs and Chinese Nature Product Database (CNPD) for potential lead compounds. The hit compounds were subsequently subjected to filtering by Lipinski's rule of five and docking study to refine the retrieved hits. Finally some of the most potent (estimated) compounds were selected from the final refined hits and suggested for further experimental investigation. Descriptors Catalytic Domain, Combinatorial Chemistry Techniques, Computer Simulation, Enzyme Inhibitors/chemistry/pharmacology, Models, Chemical, Models, Molecular, Protein Kinases/chemistry/metabolism, Structure-Activity Relationship Links Book Title Database Publisher Data Source Authors Chen,J. J., Liu,T. L., Yang,L. J., Li,L. L., Wei,Y. Q., Yang,S. Y. Original/Translated Title URL Date of Electronic PMCID Editors

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