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Hookah and Cigarette Smoking Among African American College Students: Implications for Campus Risk Reduction And Health Promotion Efforts 2016 a Department of Education , Graduate School of Arts & Sciences, Washington University in St. Louis , St. Louis , Missouri , USA.; b George Warren Brown School of Social Work, Washington University in St. Louis , St. Louis , Missouri , USA.
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Journal Article
Periodical, Full
Journal of American college health : J of ACH
Periodical, Abbrev.
J.Am.Coll.Health
Pub Date Free Form
May-Jun
Volume
64
Issue
4
Start Page
309
Other Pages
317
Notes
LR: 20160727; GR: T32 DA015035/DA/NIDA NIH HHS/United States; JID: 8214119; NIHMS792195; OID: NLM: NIHMS792195 [Available on 05/01/17]; OID: NLM: PMC4960822 [Available on 05/01/17]; OTO: NOTNLM; PMCR: 2017/05/01 00:00; ppublish
Place of Publication
United States
ISSN/ISBN
1940-3208; 0744-8481
Accession Number
PMID: 26829515
Language
eng
SubFile
Journal Article; IM
DOI
10.1080/07448481.2016.1138479 [doi]
Output Language
Unknown(0)
PMID
26829515
Abstract
OBJECTIVE: To identify individual and institutional risks and protections for hookah and cigarette smoking among African American (AA) college students. PARTICIPANTS: AA college students (N = 1,402; mean age = 20, range = 18-24 years; 75% female) who completed the Fall 2012 American College Health Association-National College Health Assessment II. METHODS: Respondents were stratified into 4 mutually exclusive groups by last-30-day smoking status: cigarette-only use (5.1%), hookah-only use (5.9%), dual use (2.4%), and nonuse (86.6%). Multinomial logistic regression models identified the relative odds of exclusive and dual hookah and cigarette smoking. RESULTS: Current hookah and cigarette smoking rates were comparably low. Age, gender identity, current substance use, interest in tobacco use information, and student population prevailed as risks and protections for hookah and cigarette smoking. CONCLUSIONS: Campus health promotion campaigns may need to tailor messages to AA students, particularly those who use substances, to underscore the health risks of hookah and cigarette smoking.
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Database
Publisher
Data Source
Authors
Jones,B.D., Cunningham-Williams,R.M.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4960822
Editors
Prevalence, correlates and patterns of waterpipe smoking among secondary school students in southeast London: a cross-sectional study 2016 Department of Primary Care and Public Health, Imperial College London, Hammersmith, W6 8RP, UK. mohammed.jawad06@imperial.ac.uk.; Academic Unit of Primary Care and Population Sciences, University of Southampton, Southampton, Hampshire, SO16 6YD, UK. moham
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Ref Type
Journal Article
Periodical, Full
BMC public health
Periodical, Abbrev.
BMC Public Health
Pub Date Free Form
1-Feb
Volume
16
Issue
Start Page
108
Other Pages
016-2770-1
Notes
LR: 20160204; JID: 100968562; OID: NLM: PMC4736266; 2015/06/02 [received]; 2016/01/22 [accepted]; 2016/02/01 [aheadofprint]; epublish
Place of Publication
England
ISSN/ISBN
1471-2458; 1471-2458
Accession Number
PMID: 26830194
Language
eng
SubFile
Journal Article; IM
DOI
10.1186/s12889-016-2770-1 [doi]
Output Language
Unknown(0)
PMID
26830194
Abstract
BACKGROUND: Waterpipe smoking is growing worldwide, but little is known of its epidemiology in the UK due to its absence from national health surveys. We sought to address this by calculating the prevalence of waterpipe smoking among secondary school students in southeast London. METHODS: We conducted a pooled secondary analysis of routine health surveillance surveys among 11-17 year olds in convenience-sampled secondary schools from three ethnically-diverse areas of southeast London. We calculated ever (lifetime) waterpipe use, and compared its sociodemographic correlates to ever (lifetime) cigarette use. In one area we collected data on patterns of waterpipe use. RESULTS: Of 2,098 respondents (mean age 14.1 +/- 1.7 years, 55.7 % male, 46.6 % of black ethnicity), ever waterpipe use was 39.6 % (95 % CI 37.6-41.7 %) and was higher than that for ever cigarette use (32.4 %; 95 % CI 30.5-34.4). While waterpipe users were significantly and independently more likely to be male and of non-white ethnicities, at least 30 % of all age, gender and ethnic sub-groups had tried waterpipe smoking. In contrast, cigarette users were more likely to be older and of white ethnicity. In one of the three areas, over a quarter of waterpipe users were occasional or regular waterpipe smokers, and most were introduced to and currently used waterpipe in waterpipe-serving premises or friends' homes. CONCLUSIONS: Waterpipe smoking prevalence was high in southeast London, and users exhibited a different sociodemographic profile to cigarette users. Waterpipe should be included in national health surveys of young people. National surveillance is warranted to help develop suitable interventions to prevent uptake and promote cessation.
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Data Source
Authors
Jawad,M., Power,G.
Original/Translated Title
URL
Date of Electronic
20160201
PMCID
PMC4736266
Editors
Dependence measures based on hookah smokers' experiences and context are needed 2016 Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA.; School of Public Health, University of Memphis, Memphis, TN, USA.; Department of Epidemiology, Robert Stempel College of Public Health,
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Print(0)
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Journal Article
Periodical, Full
Addiction (Abingdon, England)
Periodical, Abbrev.
Addiction
Pub Date Free Form
May
Volume
111
Issue
5
Start Page
936
Other Pages
Notes
JID: 9304118; CON: Addiction. 2016 Feb;111(2):351-9. PMID: 26417942; CIN: Addiction. 2016 May;111(5):937-8. PMID: 26987303; OTO: NOTNLM; 2015/12/16 [received]; 2015/12/17 [accepted]; 2016/02/02 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1360-0443; 0965-2140
Accession Number
PMID: 26841019
Language
eng
SubFile
Comment; Letter; IM
DOI
10.1111/add.13287 [doi]
Output Language
Unknown(0)
PMID
26841019
Abstract
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Myers,K., Ward,K.D., Maziak,W.
Original/Translated Title
URL
Date of Electronic
20160202
PMCID
Editors
Waterpipe Tobacco Smoking among Arab Youth; a Cross-Country Study 2016 Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology.; Department of Pediatrics, Yarmouk Hospital, Jordan Ministry of Health.; Faculty of Science, University of Jordan/ Aqaba Branch.; Department of Community and Me
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Print(0)
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Journal Article
Periodical, Full
Ethnicity & disease
Periodical, Abbrev.
Ethn.Dis.
Pub Date Free Form
21-Jan
Volume
26
Issue
1
Start Page
107
Other Pages
112
Notes
LR: 20160721; JID: 9109034; OID: NLM: PMC4738847; OTO: NOTNLM; epublish
Place of Publication
United States
ISSN/ISBN
1049-510X; 1049-510X
Accession Number
PMID: 26843803
Language
eng
SubFile
Journal Article; IM
DOI
10.18865/ed.26.1.107 [doi]
Output Language
Unknown(0)
PMID
26843803
Abstract
OBJECTIVE: Waterpipe tobacco smoking (WTS) is considered a global epidemic that is spreading among youth. Our analysis was conducted to compare the national baseline prevalence rate estimates of WTS among Arab boys and girls. DESIGN SETTING AND PARTICIPANTS: The Global Youth Tobacco Survey (GYTS) is a school-based survey using standardized self-administered questionnaires; it employs a two-stage cluster sampling technique to obtain a representative sample of youth (13-15 years of age). We conducted a secondary data analysis of nationally representative GYTSs available from 16 Arab countries. MAIN MEASURES: Youth who self-reported smoking waterpipe at least once in the past 30 days were considered to be current waterpipe tobacco smokers. National weighted WTS prevalence rate estimates along with respective 95% confidence intervals were reported for boys and girls. RESULTS: Pooled GYTS data from 16 Arab countries yielded a total of 31,359 youth. Overall, 10.6% of the respondents were current waterpipe tobacco smokers, with boys (13.7%) having significantly higher estimates than girls (7.2%). Overall, current WTS prevalence rate estimates ranged from .9% in Oman to 34.2%, in Lebanon. The WTS epidemic was more predominant among boys and girls, respectively, in the West Bank (42.8% and 24.2%), Lebanon (38.6% and 30.5%) and Jordan (25.7% and 14.5%). CONCLUSION: Among Arab boys and girls, WTS represents a growing strain of the tobacco epidemic that requires immediate attention.
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Data Source
Authors
Kheirallah,K.A., Alsulaiman,J.W., Mohammad,H.A.S., Alzyoud,S., Veeranki,S.P., Ward,K.D.
Original/Translated Title
URL
Date of Electronic
20160121
PMCID
PMC4738847
Editors
Knowledge, Beliefs, Behaviors, and Social Norms Related to Use of Alternative Tobacco Products Among Undergraduate and Graduate Nursing Students in an Urban U.S. University Setting 2016 Upsilon, Associate Professor, New, York University College of Nursing NYU Global Institute of Public Health, New York City, NY, USA.; Resident, University of Michigan School of Medicine, AnnArbor, MI, USA.; Alpha Chi, Assistant Professor, Boston College S
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Journal Article
Periodical, Full
Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau
Periodical, Abbrev.
J.Nurs.Scholarsh.
Pub Date Free Form
Mar
Volume
48
Issue
2
Start Page
147
Other Pages
153
Notes
CI: (c) 2016; JID: 100911591; OTO: NOTNLM; 2015/11/24 [accepted]; 2016/02/04 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1547-5069; 1527-6546
Accession Number
PMID: 26845631
Language
eng
SubFile
Journal Article; IM; N
DOI
10.1111/jnu.12192 [doi]
Output Language
Unknown(0)
PMID
26845631
Abstract
PURPOSE: The purpose of the study was to assess nursing students' knowledge, beliefs, behaviors, and social norms regarding use of alternative tobacco products (ATPs). DESIGN AND METHODS: This anonymous online survey was conducted with all students enrolled in a college of nursing. The survey utilized measures from several national tobacco studies to assess knowledge and beliefs about ATPs (hookahs, cigars or cigarillos, bidis, kreteks, smokeless tobacco, electronic cigarettes) compared to cigarettes, health effects of ATPs, personal use of ATPs, and social norms. Data were analyzed in SPSS 22.0 (SPSS Inc., Chicago, IL, USA). Descriptive statistics and frequencies were performed for basic sociodemographic data. Paired samples t tests were performed to determine differences for scaled measures. FINDINGS: Nursing students demonstrated very low levels of knowledge about ATPs and their health consequences, despite high rates of ATP personal use. About 76% of participants reported use of one or more ATPs once or more in their lifetimes. A greater proportion of students had used hookahs or waterpipes (39.6%) compared to cigarettes (32.7%). CONCLUSIONS: Nurses' lack of knowledge about the emerging use and health threats associated with ATPs may undermine their ability to provide appropriate tobacco cessation counseling. Research is needed to identify gaps in nurses' education regarding tobacco cessation counseling and to develop new counseling approaches specific to use of ATPs. CLINICAL RELEVANCE: Nurses play critical roles in counseling their patients for tobacco cessation. Further research and education about the risks presented by ATPs are critical to reducing excess tobacco-related mortality.
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Publisher
Sigma Theta Tau International
Data Source
Authors
VanDevanter,N., Zhou,S., Katigbak,C., Naegle,M., Sherman,S., Weitzman,M.
Original/Translated Title
URL
Date of Electronic
20160204
PMCID
Editors
Regional differences in adults' tea drinking pattern: findings from China Kadoorie Biobank study in 10 areas in China 2015 Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Email: lvjun@bjmu.edu.cn.; C
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Ref Type
Journal Article
Periodical, Full
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Periodical, Abbrev.
Zhonghua Liu Xing Bing Xue Za Zhi
Pub Date Free Form
Nov
Volume
36
Issue
11
Start Page
1195
Other Pages
1199
Notes
LR: 20160322; GR: MC_U137686851/Medical Research Council/United Kingdom; JID: 8208604; 0 (Tea); ppublish
Place of Publication
China
ISSN/ISBN
0254-6450; 0254-6450
Accession Number
PMID: 26850235
Language
chi
SubFile
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
26850235
Abstract
OBJECTIVE: To describe the gender and regional differences in adults' tea drinking pattern found in China Kadoorie Biobank (CKB) survey, involving half million adults, in 10 areas in China. METHODS: The baseline survey of CKB was conducted in 5 urban areas and 5 rural areas in China during 2004-2008. The information on tea drinking of 512 891 adults aged 30-79 years was collected and analyzed. RESULTS: The overall prevalence of regular tea drinking (i.e., weekly) was 50.7% in males and 21.3% in females. Among 10 areas, Hunan reported the highest regular tea drinking prevalence (74.3% in males, 76.6% in females), while Henan reported the lowest regular tea drinking prevalence (5.5% in males, 1.0% in females). Most regular tea drinkers consumed green tea except those from Zhejiang and Haikou. Hunan reported the highest tea consumption per time (3.8 g in males, 3.1 g in females), per day (6.2 g in males, 4.1 g in females) and per week (38.4 g in males, 25.0 g in females). CONCLUSION: The adults' tea drinking pattern i.e. frequency, type, amount of tea and preferred concentration of tea water, varied greatly among the 10 regions covered by CKB study.
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Publisher
Data Source
Authors
Li,X., Lyu,J., Guo,Y., Bian,Z., Yu,C., Zhou,H., Tan,Y., Pei,P., Chen,J., Chen,Z., Li,L., China Kadoor Biobank (CKB) Collaborative Group
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Regional differences in adults' smoking pattern: findings from China Kadoorie Biobank study in 10 areas in China 2015 Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Email: lvjun@bjmu.edu.cn.; C
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Periodical, Abbrev.
Zhonghua Liu Xing Bing Xue Za Zhi
Pub Date Free Form
Nov
Volume
36
Issue
11
Start Page
1200
Other Pages
1204
Notes
LR: 20160322; GR: MC_U137686851/Medical Research Council/United Kingdom; JID: 8208604; ppublish
Place of Publication
China
ISSN/ISBN
0254-6450; 0254-6450
Accession Number
PMID: 26850236
Language
chi
SubFile
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
26850236
Abstract
OBJECTIVE: To describe the regional differences in adults' smoking pattern found by China Kadoorie Biobank (CKB) study involving half million adults in 10 areas in China. METHODS: After exclusion of the adults with self reported histories of coronary heart disease, stroke, cancer and chronic obstructive pulmonary disease at baseline survey, the area specific differences in smoking pattern of 452 829 subjects aged 30-79 years was analyzed. RESULTS: The overall rate of current smoker was higher in males (64.2%) than in females (2.1%). For females, the current smoker rate was higher in Harbin (10.5%) and Sichuan (8.5%) than in other areas. For males, the current smoker rate and the average numbers of cigarettes smoked per day were high in Hunan (68.8%, 20.9) and Sichuan (67.2%, 21.5) ; the current smoker rate was lowest (49.9%) but the average number of cigarettes smoked per day was highest (21.9) in Haikou. On the other hand, Gansu showed the highest rate of current smoker (71.4% ) with a lower mean number of cigarettes smoked per day (14.9). Most current smokers in males (88.3% ) smoked filter cigarettes, while hand-rolled cigarettes were commonly used in Sichuan (38.8%) and Gansu (37.8%) and pipes or water pipe were mainly used in Henan (14.6%). CONCLUSION: The rate of current smoker and other patterns of smoking including cigarette type, daily amount and inhalation depth varied greatly among the adults in 10 areas covered by CKB study.
Descriptors
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Database
Publisher
Data Source
Authors
Wang,X., Lyu,J., Guo,Y., Bian,Z., Yu,C., Zhou,H., Tan,Y., Pei,P., Chen,J., Chen,Z., Li,L., China Kadoor Biobank (CKB) Collaborative Group
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Cross-section survey on smoking behavior and cognition in Chongqing, 2014 2015 Chongqing Municipal Center for Disease Control and Prevention, Chongqing 400042, China.; Chongqing Municipal Center for Disease Control and Prevention, Chongqing 400042, China; Email: xianbinding@126.com.; Chongqing Municipal Center for Disease Control an
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Periodical, Abbrev.
Zhonghua Liu Xing Bing Xue Za Zhi
Pub Date Free Form
Nov
Volume
36
Issue
11
Start Page
1236
Other Pages
1243
Notes
JID: 8208604; 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
China
ISSN/ISBN
0254-6450; 0254-6450
Accession Number
PMID: 26850243
Language
chi
SubFile
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
26850243
Abstract
OBJECTIVE: To investigate the prevalence of smoking, smoking cessation, passive smoking and awareness of the dangers of tobacco in population in Chongqing and provide evidence for developing prevention and control measures. METHODS: A total of 5 400 residents aged >/=18 years were selected from 9 districts/counties in Chongqing through stratified multi-stage cluster sampling and face-to-face interviews were conducted among them. Indicators as current smoking rates, smoking cessation rates and passive smoking rates were calculated by the weight of age proportions from 2010 population census. The analytical method was based on complex sampling design. RESULTS: The current smoking rate of the residents aged >/=18 years was 27.4% (male: 53.5% and female: 1.1%), which was highest in age group 40-50 years (58.4%) for males. The current smoking rate among rural residents was higher than that in urban residents. The prevalence of daily cigarette smoking was 27.5%, which was significantly higher in southeastern Chongqing. The rate of passive smoking was 52.4%. Among daily smokers, the mean number of cigarettes smoked was 17.5 per day (men: 17.6 per day; women: 13.5 per day). The daily smoked cigarette number in males was higher in age group 40-50 years (20.1 per day) and those with junior middle school education level (18.9 per day). The proportion of the current smokers who smoked more than 20 cigarettes per day (the rate of heavy smoker) was higher in males than in females and in rural residents than in urban residents. The proportion of heavy smokers was 59.3%, which was highest in age group 40-50 years (66.8%), followed by those with junior middle school educational level (65.2%). The average age of smokers when they stared to smoke was 20.8 years old, which was low in males and rural residents. About 80.2% of the smokers stared to smoke under 25 years old, and 70.3% of the smokers stared to smoke between 15 and 25 years old. The overall rate of smoking cessation was 20.1% and the successful smoking cessation rate was 13.7%. The two rates increased with age, the successful smoking cessation rate was lowest in age group 18-40 years (4.8%). The awareness of the tobacco risk related knowledge seemed poor among the residents, only 19.6% of the residents were aware that smoking could cause serious diseases (stoke, heart disease and lung cancer). 21.9% of the residents were aware that passive smoking could cause serious diseases (heart disease, lung disease and lung cancer). CONCLUSION: Current prevalence of smoking in males in Chongqing remains at a high level, indicating that the publicity programs on the tobacco risk related knowledge needs to be strengthened and the tobacco control needs more efforts. The tobacco control in Chongqing is still facing serious challenge.
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Publisher
Data Source
Authors
Shen,Z., Ding,X., Mao,D., Zhang,C., Lyu,X., Jiao,Y., Qi,L.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Highly selective and effective solid phase microextraction of benzoic acid esters using ionic liquid functionalized multiwalled carbon nanotubes-doped polyaniline coating 2016 Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials &
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of chromatography.A
Periodical, Abbrev.
J.Chromatogr.A
Pub Date Free Form
11-Mar
Volume
1437
Issue
Start Page
1
Other Pages
7
Notes
CI: Copyright (c) 2016; JID: 9318488; 0 (Aniline Compounds); 0 (Esters); 0 (Ionic Liquids); 0 (Nanotubes, Carbon); 0 (Water Pollutants, Chemical); 0 (polyaniline); 8SKN0B0MIM (Benzoic Acid); OTO: NOTNLM; 2015/09/30 [received]; 2016/01/04 [revised]; 2016/0
Place of Publication
Netherlands
ISSN/ISBN
1873-3778; 0021-9673
Accession Number
PMID: 26852620
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.chroma.2016.01.072 [doi]
Output Language
Unknown(0)
PMID
26852620
Abstract
The present work reports the electrochemical fabrication of an ionic liquid functionalized multiwalled carbon nanotubes-polyaniline (MWCNT@IL/PANI) nanocomposite coating and its application in the headspace-solid phase microextraction (HS-SPME) and gas chromatography (GC) determination of benzoic acid esters (i.e., methyl benzoate, ethyl benzoate, propyl benzoate and butyl benzoate). The MWCNTs was firstly functionalized with amine-terminated IL (MWCNT@IL) through chemical reduction, and then was doped in PANI during the electropolymerization of aniline. The resulting coating was characterized by infrared spectroscopy, field emission scanning electron microscopy and thermo gravimetry. It showed net-like structure and had high thermal stability (up to 330 degrees C). Furthermore, it presented high selectivity for the four benzoic acid esters and thus suited for their HS-SPME-GC determination. Results showed that under optimized extraction conditions, the detection limits were less than 6.1ngL(-1) (S/N=3) and the linear detection ranges were 0.012-50mugL(-1) (R>/=0.9957) for these analytes. The relative standard deviations (RSDs) were lower than 6.4% for five successive measurements with one fiber, and the RSDs for fiber-to-fiber were 4.4-9.6% (n=5). The developed method was successfully applied to the determination of these benzoic acid esters in perfume samples.
Descriptors
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Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Ai,Y., Wu,M., Li,L., Zhao,F., Zeng,B.
Original/Translated Title
URL
Date of Electronic
20160202
PMCID
Editors
Gender difference in gastro-esophageal reflux diseases 2016 Kiyotaka Asanuma, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi Prefecture 980-8574, Japan.; Kiyotaka Asanuma, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, To
Source Type
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Ref Type
Journal Article
Periodical, Full
World journal of gastroenterology
Periodical, Abbrev.
World J.Gastroenterol.
Pub Date Free Form
7-Feb
Volume
22
Issue
5
Start Page
1800
Other Pages
1810
Notes
LR: 20160210; JID: 100883448; OID: NLM: PMC4724611; OTO: NOTNLM; 2015/06/25 [received]; 2015/10/07 [revised]; 2015/12/30 [accepted]; ppublish
Place of Publication
United States
ISSN/ISBN
2219-2840; 1007-9327
Accession Number
PMID: 26855539
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.3748/wjg.v22.i5.1800 [doi]
Output Language
Unknown(0)
PMID
26855539
Abstract
The incidence of esophageal adenocarcinoma (EAC) has risen sharply in western countries over the past 4 decades. This type of cancer is considered to follow a transitional process that goes from gastro-esophageal reflux disease (GERD) to Barrett's esophagus (BE, a metaplastic condition of the distal esophagus), a precursor lesion and ultimately adenocarcinoma. This spectrum of GERD is strongly predominant in males due to an unidentified mechanism. Several epidemiologic studies have described that the prevalence of GERD, BE and EAC in women is closely related to reproductive status, which suggests a possible association with the estrogen level. Recently, we revealed in an in vivo study that the inactivation of mast cells by the anti-inflammatory function of estrogen may account for the gender difference in the GERD spectrum. Other studies have described the contribution of female steroid hormones to the gender difference in these diseases. Estrogen is reported to modulate the metabolism of fat, and obesity is a main risk factor of GERDs. Moreover, estrogen could confer esophageal epithelial resistance to causative refluxate. These functions of estrogen might explain the approximately 20-year delay in the incidence of BE and the subsequent development of EAC in women compared to men, and this effect may be responsible for the male predominance. However, some observational studies demonstrated that hormone replacement therapy exerts controversial effects in GERD patients. Nevertheless, the estrogen-related endocrine milieu may prevent disease progression toward carcinogenesis in GERD patients. The development of innovative alternatives to conventional acid suppressors may become possible by clarifying the mechanisms of estrogen.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Asanuma,K., Iijima,K., Shimosegawa,T.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4724611
Editors