WTS database

Title	Pub Year	Author Sort descending	SearchLink
Poor sleep quality and obstructive sleep apnea in patients with GERD and Barrett's esophagus	2014	Section of Gastroenterology and Hepatology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Periodical, Abbrev. Neurogastroenterol.Motil. Pub Date Free Form Mar Volume 26 Issue 3 Start Page 346 Other Pages 352 Notes LR: 20150515; CI: (c) 2013; GR: DK58338/DK/NIDDK NIH HHS/United States; GR: K24 DK078154/DK/NIDDK NIH HHS/United States; GR: K24-04-107/PHS HHS/United States; GR: P30 DK056338/DK/NIDDK NIH HHS/United States; GR: R01 116845/PHS HHS/United States; GR: R01 C Place of Publication England ISSN/ISBN 1365-2982; 1350-1925 Accession Number PMID: 24460751 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI 10.1111/nmo.12265 [doi] Output Language Unknown(0) PMID 24460751 Abstract BACKGROUND: Gastroesophageal reflux disease (GERD) reduces sleep quality. Whether Barrett's esophagus (BE) affects sleep differently is unknown. Obstructive sleep apnea (OSA) often coexists with GERD and may disrupt sleep; whether GERD reduces sleep quality independently of OSA is unknown. Our aims were to compare the effect of GERD and BE on sleep quality, and assess the impact of OSA on this association. METHODS: Validated questionnaires for GERD symptoms, sleep quality, and OSA risk were prospectively administered to subjects undergoing upper endoscopy. GERD was defined by erosive esophagitis and/or reflux symptoms >1/week. BE was defined histologically. Controls had normal endoscopy and were asymptomatic. Poor sleep quality was defined by a Pittsburgh Sleep Quality Index score >5. Risk of OSA was defined by a positive Berlin Questionnaire. The risk poor sleep quality in GERD, BE, and controls was evaluated in multivariate models. KEY RESULTS: 83 GERD, 63 BE, and 75 controls were included. OSA and poor sleep quality were significantly more frequent in GERD (65% and 60%) but not BE (52% and 46%) compared with controls (48% and 39%). Controlling for age, race, gender, smoking, body mass index, and hypertension, the risk of poor sleep quality was significantly increased in GERD compared with controls (odds ratio [OR] = 2.79, 95% confidence interval [CI]: 1.08-6.80), significance was lost after adding OSA to the model (OR = 2.27, 95% CI: 0.87-5.85). CONCLUSIONS & INFERENCES: GERD but not BE increases the risk of poor sleep quality. This association is not independent of OSA. Descriptors Links Book Title Database Publisher John Wiley & Sons Ltd Data Source Authors Vela,M.F., Kramer,J.R., Richardson,P.A., Dodge,R., El-Serag,H.B. Original/Translated Title URL Date of Electronic 20131209 PMCID PMC3944589 Editors
Smoking and Barrett's esophagus in women who undergo upper endoscopy	2011	Section of Gastroenterology, Department of Medicine, Boston University Medical Center, 85 East Concord Street, Room 7721, Boston, MA 02118, USA. brian.jacobson@bmc.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Digestive diseases and sciences Periodical, Abbrev. Dig.Dis.Sci. Pub Date Free Form Jun Volume 56 Issue 6 Start Page 1707 Other Pages 1717 Notes LR: 20151119; GR: CA087969/CA/NCI NIH HHS/United States; GR: R01 DK088782/DK/NIDDK NIH HHS/United States; GR: R01 DK088782-01/DK/NIDDK NIH HHS/United States; GR: R01DK088782/DK/NIDDK NIH HHS/United States; JID: 7902782; NIHMS287457; OID: NLM: NIHMS287457; Place of Publication United States ISSN/ISBN 1573-2568; 0163-2116 Accession Number PMID: 21448698 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; AIM; IM DOI 10.1007/s10620-011-1672-4 [doi] Output Language Unknown(0) PMID 21448698 Abstract BACKGROUND: Cigarette use is associated with esophageal adenocarcinoma, and cross-sectional studies suggest an association between smoking and Barrett's esophagus. AIMS: We sought to examine prospectively the effect of smoking on the risk for Barrett's esophagus. METHODS: This was a prospective cohort study among 20,863 women within the Nurses' Health Study who underwent upper gastrointestinal endoscopy for any reason between 1980 and 2006. We assessed the association between smoking and pathologically-confirmed Barrett's esophagus (n = 377). Self-reported data on smoking and potential confounding variables were collected from biennial questionnaires. RESULTS: Compared with women who never smoked, former smokers of 1-24 cigarettes/day had a multivariate odds ratio for Barrett's esophagus of 1.25 (95% CI 0.99-1.59), former smokers of >/= 25 cigarettes/day had a multivariate odds ratio of 1.52 (95% CI 1.04-2.22), current smokers of 1-24 cigarettes/day had a multivariate odds ratio of 0.89 (95% CI 0.54-1.45), and current smokers of >/= 25 cigarettes/day had a multivariate odds ratio of 0.92 (95% CI 0.34-2.54). The risk for Barrett's esophagus increased significantly with increasing pack-years smoked among former (P = 0.008) but not current smokers (P = 0.99), especially when considering exposure >/= 25 years before index endoscopy. Results were similar among women reporting regular heartburn/acid-reflux one or more times a week, and were not accounted for by changes in weight. CONCLUSIONS: Heavy, remote smoking is associated with an increased risk for Barrett's esophagus. This finding suggests a long latency period between exposure and development of the disease, even after discontinuation of smoking. Descriptors Links Book Title Database Publisher Data Source Authors Jacobson,B.C., Giovannucci,E.L., Fuchs,C.S. Original/Translated Title URL Date of Electronic 20110330 PMCID PMC3100531 Editors
Body mass index and Barrett's oesophagus in women	2009	Section of Gastroenterology, Department of Medicine, Boston University Medical Center, 88 East Concord Street, Room 7721, Boston, MA 02118, USA. brian.jacobson@bmc.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Gut Periodical, Abbrev. Gut Pub Date Free Form Nov Volume 58 Issue 11 Start Page 1460 Other Pages 1466 Notes LR: 20151119; GR: CA087969/CA/NCI NIH HHS/United States; GR: CA107412/CA/NCI NIH HHS/United States; GR: K07 CA107412/CA/NCI NIH HHS/United States; GR: K07 CA107412-04/CA/NCI NIH HHS/United States; GR: K08 DK070706/DK/NIDDK NIH HHS/United States; GR: K08 D Place of Publication England ISSN/ISBN 1468-3288; 0017-5749 Accession Number PMID: 19336423 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; AIM; IM DOI 10.1136/gut.2008.174508 [doi] Output Language Unknown(0) PMID 19336423 Abstract OBJECTIVE: Excess body mass is associated with symptoms of gastro-oesophageal reflux disease, and cross-sectional studies suggest an association between body mass index (BMI) and Barrett's oesophagus. The present study sought prospectively to examine the influence of BMI and other anthropomorphic measures on the risk for Barrett's oesophagus among women. METHODS: This was a prospective study of 15 861 women who participated in the Nurses' Health Study, without a history of cancer, who underwent upper gastrointestinal endoscopy for any reason between 1986 and 2004. The main outcome measures were 261 cases of pathologically confirmed specialised intestinal metaplasia within the oesophagus (Barrett's oesophagus). Self-reported data on weight were collected from biennial questionnaires. Self-reported height was collected in 1976, and self-reported waist and hip circumferences were collected in 1986. RESULTS: Compared with women with a BMI of 20-24.9 kg/m(2), women with a BMI of 25-29.9 had a multivariate OR for Barrett's oesophagus of 0.92 (95% CI 0.66 to 1.27), women with a BMI > or =30 had a multivariate OR of 1.52 (95% CI 1.02 to 2.28) and women with a BMI <20 had a multivariate OR of 0.92 (95% CI 0.65 to 1.31). Results were similar when controlling for symptoms of gastro-oesophageal reflux, and among the entire Nurses' Health Study cohort (n = 93 609) regardless of a history of endoscopy. In contrast, waist-to-hip ratio, waist circumference and height did not appear to be associated with Barrett's oesophagus. CONCLUSIONS: Obese, but not overweight, women appear to be at increased risk for Barrett's oesophagus. Descriptors Adult, Barrett Esophagus/etiology, Body Mass Index, Endoscopy, Digestive System, Female, Gastroesophageal Reflux/complications, Humans, Intestines/pathology, Metaplasia/pathology, Middle Aged, Odds Ratio, Overweight/complications, Precancerous Conditions/etiology, Prospective Studies, Risk Factors, Surveys and Questionnaires, Waist Circumference, Waist-Hip Ratio Links Book Title Database Publisher Data Source Authors Jacobson,B. C., Chan,A. T., Giovannucci,E. L., Fuchs,C. S. Original/Translated Title URL Date of Electronic 20090330 PMCID PMC2763036 Editors
Risk of upper gastrointestinal cancers in patients with gastroesophageal reflux disease after a negative screening endoscopy	2015	Section of Health Services Research, Houston Veterans Affairs Health Services Research and Development Center of Excellence, Houston, Texas; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; S	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Periodical, Abbrev. Clin.Gastroenterol.Hepatol. Pub Date Free Form Feb Volume 13 Issue 2 Start Page 280 Other Pages 286 Notes LR: 20160202; CI: Copyright (c) 2015; GR: K24 DK078154/DK/NIDDK NIH HHS/United States; GR: P30 DK056338/DK/NIDDK NIH HHS/United States; GR: R01 CA116845/CA/NCI NIH HHS/United States; GR: R01 NCI RC4 155844/RC/CCR NIH HHS/United States; GR: UK58338/PHS HHS Place of Publication United States ISSN/ISBN 1542-7714; 1542-3565 Accession Number PMID: 25004461 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1016/j.cgh.2014.06.029 [doi] Output Language Unknown(0) PMID 25004461 Abstract BACKGROUND & AIMS: Practice guidelines recommend a 1-time screening endoscopy for patients with gastroesophageal reflux disease (GERD) who are at high risk for Barrett's esophagus or malignancy. However, little is known about the risk of cancer in patients with negative findings from screening endoscopies. METHODS: We conducted a retrospective cohort study using data from 121 Veterans Health Administration facilities nationwide to determine the incidence rate of esophageal adenocarcinoma (EA) separately, as well as any upper gastrointestinal cancers, in patients with an initial negative screening endoscopy (esophagogastroduodenoscopy [EGD]). We included veteran patients with GERD diagnosed between 2004 and 2009 who had a negative screening EGD within 1 year of diagnosis. We estimated the incidence rate of EA, and any upper gastrointestinal cancer, in patients with GERD who had a negative screening EGD. We examined differences in demographic, clinical, and facility factors among patients with and without cancer. RESULTS: We identified 68,610 patients with GERD and a negative screening EGD (mean age, 55.5 y; 90% men; 67.5% white). During a mean follow-up period of 3.2 years, 10 patients developed EA and 29 patients developed any upper gastrointestinal malignancies, including EA. The incidence of subsequent EA in this group was 4.6/100,000 patient-years of follow-up evaluation, whereas the incidence of any upper gastrointestinal cancers was 13.2/100,000 patient-years of follow-up evaluation. Patients with a subsequent cancer were significantly older and had higher comorbidity scores than patients without cancer. Other clinical and facility factors did not differ significantly between these 2 groups. CONCLUSIONS: The risk of cancer is low, over a mean 3-year period, for patients with GERD who had a negative screening endoscopy. These findings justify recommendations for a 1-time screening endoscopy for patients with GERD. Descriptors Links Book Title Database Publisher AGA Institute. Published by Elsevier Inc Data Source Authors Shakhatreh,M.H., Duan,Z., Avila,N., Naik,A.D., Kramer,J.R., Hinojosa-Lindsey,M., Chen,J., El-Serag,H.B. Original/Translated Title URL Date of Electronic 20140705 PMCID PMC4284151 Editors
Quinacrine inhibits Candida albicans growth and filamentation at neutral pH	2014	Section of Infectious Diseases, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA.; Section of Infectious Diseases, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA Division of Infectious Diseases, University of New	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Dec Volume 58 Issue 12 Start Page 7501 Other Pages 7509 Notes LR: 20151029; CI: Copyright (c) 2014; GR: K12 GM088021/GM/NIGMS NIH HHS/United States; JID: 0315061; 0 (Antifungal Agents); 0 (Antiprotozoal Agents); 0 (Drug Combinations); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL Place of Publication United States ISSN/ISBN 1098-6596; 0066-4804 Accession Number PMID: 25288082 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI 10.1128/AAC.03083-14 [doi] Output Language Unknown(0) PMID 25288082 Abstract Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in part due to its strong propensity to form biofilms. Drug repurposing is an approach that might identify agents that are able to overcome antifungal drug resistance within biofilms. Quinacrine (QNC) is clinically active against the eukaryotic protozoan parasites Plasmodium and Giardia. We sought to investigate the antifungal activity of QNC against C. albicans biofilms. C. albicans biofilms were incubated with QNC at serially increasing concentrations (4 to 2,048 mug/ml) and assessed using a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay in a static microplate model. Combinations of QNC and standard antifungals were assayed using biofilm checkerboard analyses. To define a mechanism of action, QNC was assessed for the inhibition of filamentation, effects on endocytosis, and pH-dependent activity. High-dose QNC was effective for the prevention and treatment of C. albicans biofilms in vitro. QNC with fluconazole had no interaction, while the combination of QNC and either caspofungin or amphotericin B demonstrated synergy. QNC was most active against planktonic growth at alkaline pH. QNC dramatically inhibited filamentation. QNC accumulated within vacuoles as expected and caused defects in endocytosis. A tetracycline-regulated VMA3 mutant lacking vacuolar ATPase (V-ATPase) function demonstrated increased susceptibility to QNC. These experiments indicate that QNC is active against C. albicans growth in a pH-dependent manner. Although QNC activity is not biofilm specific, QNC is effective in the prevention and treatment of biofilms. QNC antibiofilm activity likely occurs via several independent mechanisms: vacuolar alkalinization, inhibition of endocytosis, and impaired filamentation. Further investigation of QNC for the treatment and prevention of biofilm-related Candida CR-BSI is warranted. Descriptors Links Book Title Database Publisher American Society for Microbiology. All Rights Reserved Data Source Authors Kulkarny,V.V., Chavez-Dozal,A., Rane,H.S., Jahng,M., Bernardo,S.M., Parra,K.J., Lee,S.A. Original/Translated Title URL Date of Electronic 20141006 PMCID PMC4249548 Editors
Effect of dentin primer on shear bond strength of composite resin to moist and dry enamel	2000	Section of Operative Dentistry, Department of Restorative Dentistry, Southern Illinois University-School of Dental Medicine, Alton, IL 62002, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Operative dentistry Periodical, Abbrev. Oper.Dent. Pub Date Free Form Jan-Feb Volume 25 Issue 1 Start Page 51 Other Pages 58 Notes LR: 20131121; JID: 7605679; 0 (Composite Resins); 0 (Dentin-Bonding Agents); 0 (Optibond); 0 (Resin Cements); 0 (Scotchbond Multi-Purpose); 0 (Z100 composite resin); 0 (single bond); 059QF0KO0R (Water); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate); 7631 Place of Publication United States ISSN/ISBN 0361-7734; 0361-7734 Accession Number PMID: 11203791 Language eng SubFile Comparative Study; Journal Article; D DOI Output Language Unknown(0) PMID 11203791 Abstract The etched enamel-composite resin bond is the most reliable bond known to us. Moisture and dentin primers are the two most important variables that can interfere with this bond. This study investigated the effect of dentin primer on bond strengths of composite resin to moist and dry enamel. One hundred freshly extracted molar teeth were used for shear bond strength testing. The teeth were mounted in phenolic rings with an approximal enamel surface exposed. The exposed enamel surface on each tooth was flattened using 320- 400- and 600-grit silicon carbide papers and etched using 34-38% phosphoric acid gel. The teeth were then divided into 10 groups (n = 10). Four groups were assigned to each of the two dentin bonding systems, Scotchbond Multi-Purpose and OptiBond FL. Two groups were assigned to the single-bottle bonding agent (Single Bond). Each bonding system was tested on moist and dry enamel. OptiBond FL and Scotchbond MP were tested with and without the use of primer. All samples were thermocycled and tested in shear. Fracture analysis was performed using a binocular microscope. For scanning electron microscopy, approximal samples of enamel (1 mm thick) were flattened, etched, and bonded with and without primer on moist and dry enamel. A 1 mm-thick layer of Z100 was bonded to the specimens, which were then immersed in 10% HCl for 24 hours to dissolve the enamel. The specimens were viewed under a scanning electron microscope. Results indicated that the use of primer on dry enamel did not significantly affect (P > 0.05) shear bond strengths for the two bonding systems, Scotchbond MP (primed 24.10 +/- 4.83 MPa, unprimed 29.57 +/- 7.49 MPa) and OptiBond FL (primed 26.82 +/- 4.44, unprimed 25.66 +/- 2.95). However, the use of primer was found to be essential on moist enamel to obtain acceptable bond strengths with both Scotchbond MP (primed 25.61 +/- 10.29 MPa, unprimed 3.26 +/- 0.95 MPa) and OptiBond FL (primed 30.28 +/- 3.49 MPa, unprimed 8.37 +/- 3.31 MPa). Moisture on enamel did not significantly affect (P > 0.05) bond strengths for the single-bottle bonding agent, Single Bond (moist enamel 31.34 +/- 9.03 MPa, dry enamel 27.93 +/- 5.41 MPa). Fracture analysis revealed that most fractures were adhesive or mixed, with a greater percentage being cohesive for the groups with dry enamel or with primer on moist enamel. Scanning electron micrographs corroborated the shear bond strength data. The specimens without primer on moist enamel showed very poor penetration of adhesive and composite resin into the etched enamel microporosities. Descriptors Analysis of Variance, Bisphenol A-Glycidyl Methacrylate, Composite Resins, Dental Bonding, Dental Enamel/chemistry, Dental Enamel Permeability, Dental Stress Analysis, Dentin-Bonding Agents, Desiccation, Humans, Materials Testing, Microscopy, Electron, Scanning, Molar, Resin Cements, Silicon Dioxide, Statistics, Nonparametric, Tensile Strength, Water, Zirconium Links Book Title Database Publisher Data Source Authors Jain,P., Stewart,G. P. Original/Translated Title URL Date of Electronic PMCID Editors
Knowledge, attitudes and practice of university students regarding waterpipe smoking in Pakistan	2008	Section of Pulmonary and Critical Care Medicine, Aga Khan University, Karachi, Pakistan. alijawaid84@gmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Periodical, Abbrev. Int.J.Tuberc.Lung Dis. Pub Date Free Form Sep Volume 12 Issue 9 Start Page 1077 Other Pages 1084 Notes LR: 20151119; JID: 9706389; 059QF0KO0R (Water); ppublish Place of Publication France ISSN/ISBN 1027-3719; 1027-3719 Accession Number PMID: 18713508 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 18713508 Abstract OBJECTIVES: To study the awareness, perceptions and practice of university students in Karachi, Pakistan, with regard to shisha (waterpipe) smoking. DESIGN: Cross-sectional survey conducted among students at four different universities of Karachi, selected through random cluster sampling. RESULTS: A total of 450 participants, 59.6% males (n=268) and 40.4% females (n=182), were included in the study. About half of the participants reported having ever smoked shisha (n=241, 53.6%). On examining factors associated with starting shisha smoking, curiosity was found to be the most common reason (n=148, 61.4%), followed by pleasure-seeking (n=113, 46.9%), peer pressure (n=55, 22.8%), boredom (n=43, 17.8%) and stress (n=26, 10.8%). Of 241 participants who had ever smoked waterpipes, the majority (n=149, 61.8%) were current smokers. A vast majority of participants (n=269, 60%) considered waterpipe smoking to be less unhealthy than cigarette smoking. Boredom in youth, use of waterpipe in leisure activities and peer pressure were identified as the most common reasons for the escalating popularity of waterpipe smoking in Pakistan. CONCLUSIONS: Waterpipe smoking is very popular among Pakistani university students, and knowledge among university students about the dangers of waterpipe smoking is alarmingly low. Descriptors Adult, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Logistic Models, Male, Pakistan/epidemiology, Prevalence, Risk Factors, Smoking/epidemiology, Students/statistics & numerical data, Surveys and Questionnaires, Universities, Water Links Book Title Database Publisher Data Source Authors Jawaid,A., Zafar,A. M., Rehman,T. U., Nazir,M. R., Ghafoor,Z. A., Afzal,O., Khan,J. A. Original/Translated Title URL Date of Electronic PMCID Editors
Nocturnal stomatal conductance effects on the Î´18O signatures of foliage gas exchange observed in two forest ecosystems	2007	Seibt, U., Department of Global Ecology, Carnegie Institution of Washington, Stanford, CA 94305, United States	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tree physiology Periodical, Abbrev. Tree Physiol. Pub Date Free Form / Volume 27 Issue 4 Start Page 585 Other Pages 595 Notes Place of Publication ISSN/ISBN 0829-318X Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract We report field observations of oxygen isotope (18O) discrimination during nocturnal foliage respiration (18Î” R) in branch chambers in two forest ecosystems: a Sitka spruce (Picea sitchensis (Bong.) Carr.) plantation in Scotland; and a beech (Fagus sylvatica L.) forest in Germany. We used observations and modeling to examine the impact of nocturnal stomatal conductance on the 18O/16O (Î´18O) signatures of foliage gas exchange at night. We found that nocturnal stomatal conductance can influence the Î´18O signature by affecting: (1) the bidirectional diffusion of CO2 into and out of the leaf (with isotopie equilibration); and (2) the 18O enrichment of the foliage water with which the CO2 equilibrates. Both effects were manifest in high apparent 18Î”R values and enriched Î´18O signatures of foliage water at night. The effects were more pronounced for Sitka spruce because of its higher nocturnal stomatal conductance and higher specific leaf water content compared to beech. We found that taking the effects of nocturnal stomatal conductance into account may change the sign of the Î´18O signature of nocturnal foliage respiration, generally thought to decrease the Î´18O of atmospheric CO2. We conclude that nocturnal stomatal exchange can have a profound effect on isotopic exchange depending on species and environmental conditions. These effects can be important when using Î´18O signatures of canopy CO2 to distinguish foliage and soil respiration, and when modeling the Î´18O signature of CO2 exchanged between ecosystems and the atmosphere. Â© 2007 Heron Publishing. Descriptors carbon dioxide, oxygen, beech, biological model, circadian rhythm, conference paper, darkness, ecosystem, metabolism, plant leaf, spruce, tree Links Book Title Database MEDLINE Publisher Data Source Embase Authors Seibt,U., Wingate,L., Berry,J. A. Original/Translated Title URL Date of Electronic PMCID Editors
Aspects of the design protocol and the statistical methods for analysis of tar, nicotine and carbon monoxide yields in cigarette smoke that can affect the measurement variability within collaborative studies	2013	SEITA, Imperial Tobacco Group, 48 rue Danton, 45404 Fleury-les-Aubrais, France.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Regulatory toxicology and pharmacology : RTP Periodical, Abbrev. Regul.Toxicol.Pharmacol. Pub Date Free Form Nov Volume 67 Issue 2 Start Page 252 Other Pages 265 Notes LR: 20151119; CI: Copyright (c) 2013; JID: 8214983; 0 (Smoke); 0 (Tars); 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); OTO: NOTNLM; 2013/06/10 [received]; 2013/08/05 [revised]; 2013/08/07 [accepted]; 2013/08/16 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1096-0295; 0273-2300 Accession Number PMID: 23959062 Language eng SubFile Journal Article; IM DOI 10.1016/j.yrtph.2013.08.004 [doi] Output Language Unknown(0) PMID 23959062 Abstract Statistical principles described in ISO 5725-1 (1994) are a robust basis for evaluating cigarette smoke data from collaborative studies under the ISO 3308 machine smoking and for specifying the criteria for the removal of outlier data and determination of mean yields and their variability. However, the standard only provides recommendations on outlier removal that should be taken into account by experts who undertake data interpretation. The potential for over-interpretation of data from small numbers of laboratories is highlighted and recommendations made to deal with this possibility. Key variables to the statistical analysis, the number of cigarettes per replicate and replicates performed in each laboratory, the number of participating laboratories and the use of linear and rotary smoking machines in smoke collection, are identified and their relevance to obtaining robust data are considered. The statistical methods routinely used for data analysis from the ISO regime, are re-assessed for their suitability to analyse data obtained under the Canadian intense (CI) regime, where yield differences between linear and rotary smoking machines are found. This machine effect can lead to more outliers being detected and difficulties in outlier detection which may affect the provision of robust estimates of mean yields, repeatability and reproducibility. Descriptors Links Book Title Database Publisher Elsevier Inc Data Source Authors Verron,T., Czechowicz,M., Heller,W.D., Cahours,X., Purkis,S.W. Original/Translated Title URL Date of Electronic 20130816 PMCID Editors
Patent foramen ovale and decompression illness in divers	2010	Seksjon for pediatri, Institutt for klinisk medisin, Universitetet i Bergen, Norway.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke Periodical, Abbrev. Tidsskr.Nor.Laegeforen. Pub Date Free Form 22-Apr Volume 130 Issue 8 Start Page 834 Other Pages 838 Notes JID: 0413423; RF: 41; ppublish Place of Publication Norway ISSN/ISBN 0807-7096; 0029-2001 Accession Number PMID: 20418929 Language nor SubFile English Abstract; Journal Article; Review; IM DOI 10.4045/tidsskr.09.0377 [doi] Output Language Unknown(0) PMID 20418929 Abstract BACKGROUND: About 25 % of the population has patent foramen ovale, and the condition has been assumed to be a causal factor in decompressive illness. Transcatheter closure is possible and is associated with a relatively low risk, but it has not been clarified whether there is an indication for assessment and treatment of the condition in divers. The present study explored a possible relationship between a patent foramen ovale and the risk for decompression illness in divers, if there are categories of divers that should be screened for the condition and what advice should be given to divers with this condition. MATERIAL AND METHODS: The review is based on literature identified through a search in Pubmed and the authors' long clinical experience in the field. RESULTS: The risk of decompression illness for divers with a persistent foramen ovale is about five times higher than that in divers without this condition, but the absolute risk for decompression illness is only 2.5 after 10,000 dives. A causal association has not been shown between patent foramen ovale and decompression illness. Even if closure of patent foramen ovale may be done with relatively small risk, the usefulness of the procedure has not been documented in divers. INTERPRETATION: We do not recommend screening for patent foramen ovale in divers because the absolute risk of decompression illness is small and transcatheter closure is only indicated after decompression illness in some occupational divers. Descriptors Decompression Sickness/etiology, Diving/injuries, Echocardiography, Transesophageal, Foramen Ovale, Patent/complications/diagnosis/therapy, Humans, Occupational Health, Risk Factors Links Book Title Database Publisher Data Source Authors Sivertsen,W., Risberg,J., Norgard,G. Original/Translated Title Apent foramen ovale og trykkfallssyke hos dykkere URL Date of Electronic PMCID Editors

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