WTS database | WHO FCTC

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The acute effects of Waterpipe smoking on the cardiovascular and respiratory systems	2008		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full J Prev Med Hyg Periodical, Abbrev. Pub Date Free Form Volume 49 Issue 3 Start Page 101 Other Pages 7 Notes ID: 19278135 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract OBJECTIVE: To assess the acute effects of smoking in Waterpipe (WP) smokers in Ajman, United Arab Emirates (UAE). CONTEXT: 202 male volunteers aged > 17 years were included. Blood pressure, heart rate and respiratory rate values of each participant, before and after a 30 minute smoking session, were measured and compared. Standardized questionnaires were also answered. RESULTS: Mean increases in systolic blood pressure (16 +/- 1 mmHg), diastolic blood pressure (2 +/- 0.7 mmHg), heart rate (6.30 +/- 0.60 bpm) and respiratory rate (2 +/- 2 breathes/min) were observed (p < 0.001). 92% of smokers believed Waterpipe smoking (WPS) to be harmful to health and 77% of smokers took up WPS for reasons of leisure. Results from the questionnaire revealed a significant relationship between smokers' beliefs of WPS and attempts to quit smoking ie. smokers who believed waterpipe to be harmful were more likely to try to quit. Education had influence on smokers ideas on WPS. 69% of smokers who claimed hookah is harmful had university qualification and further 23% has highschool qualification. CONCLUSIONS: Smoking Waterpipe has significant effects on both the cardiovascular and respiratory system. Waterpipe smokers despite sound knowledge, show little concern towards health. Education plays an important role and creates awareness about the hazards of smoking practices, including Waterpipe. Descriptors Cardiovascular System, Respiratory System, Smoking/adverse effects, Adolescent, Adult, Blood Pressure, Cross-Sectional Studies, Diastole, Health Behavior, Heart Rate, Humans, Male, Risk-Taking, Questionnaires, Systole, Time Factors, United Arab Emirates, Young Adult Links http://pesquisa.bvsalud.org/ghl/resource/en/mdl-19278135 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Shaikh,R. B., Vijayaraghavan,N., Sulaiman,A. S., Kazi,S., Shafi,M. S. M. Original/Translated Title URL Date of Electronic PMCID Editors
The allure of the waterpipe: a narrative review of factors affecting the epidemic rise in waterpipe smoking among young persons globally	2015	Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.; School of Public Health, University of Memphis, Memphis, Tennessee, USA.; Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.; Faculty of Health Scie	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Mar Volume 24 Suppl 1 Issue Start Page i13 Other Pages i21 Notes LR: 20150319; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; JID: 9209612; 059QF0KO0R (Water); OID: NLM: PMC434597 Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 25618895 Language eng SubFile Journal Article; Review; IM DOI 10.1136/tobaccocontrol-2014-051906 [doi] Output Language Unknown(0) PMID 25618895 Abstract OBJECTIVE: The objective of this narrative review is to highlight the determinants of the epidemic rise in waterpipe tobacco smoking (WTS) among youth globally. The Ecological Model of Health Promotion (EMHP) was the guiding framework for the review. DATA SOURCES: The following electronic databases were searched: Cochrane library, MEDLINE, EMBASE, PsycINFO, Web of Science and CINAHL Plus with Full Text. Search terms included waterpipe and its many variant terms. STUDY SELECTION: Articles were included if they were published between 1990 and 2014, were in English, were available in full text and included the age group 10-29 years. DATA EXTRACTION: Articles which analysed determinants of WTS at any of the levels of the EMHP were retained regardless of methodological rigour: 131 articles are included. Articles were coded in a standard template that abstracted methods as well as results. DATA SYNTHESIS: The review found that methodologies used to assess determinants of WTS among youth were often conventional and lacked rigor: 3/4 of the studies were cross-sectional surveys and most enrolled non-representative samples. Within the framework, the review identified determinants of WTS at the intrapersonal, interpersonal, organisational, community and policy levels. CONCLUSIONS: The review suggests potential interventions to control WTS among youth, with emphasis on creative utilisation of social media, and tobacco control policies that include the specificities of WTS. The review further suggests the need for rigorous qualitative work to better contextualise determinants, and prospective observational and experimental studies that track and manipulate them to assess their viability as intervention targets. Descriptors Links Book Title Database Publisher Data Source Authors Akl,E.A., Ward,K.D., Bteddini,D., Khaliel,R., Alexander,A.C., Lotfi,T., Alaouie,H., Afifi,R.A. Original/Translated Title URL Date of Electronic 20150124 PMCID PMC4345979 Editors
The assessment and management of inner ear barotrauma in divers and recommendations for returning to diving	2014	Faculty of Heath Sciences, University of Tasmania, and Medical Co-directors, Department of Diving and Hyperbaric Medicine, Royal Hobart Hospital, PO Box 744, North Hobart, Tasmania 7002, Australia, Phone: +61-(0)414-344744, Fax: +61-(0)3-6222-7268, E-mail	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Diving and hyperbaric medicine Periodical, Abbrev. Diving.Hyperb.Med. Pub Date Free Form Dec Volume 44 Issue 4 Start Page 208 Other Pages 222 Notes JID: 101282742; OTO: NOTNLM; 2014/07/06 [received]; 2014/10/15 [accepted]; ppublish Place of Publication Australia ISSN/ISBN 1833-3516; 1833-3516 Accession Number PMID: 25596834 Language eng SubFile Journal Article; Review; IM DOI Output Language Unknown(0) PMID 25596834 Abstract Inner ear barotrauma (IEBt) constitutes a spectrum of pressure-related pathology in the inner ear, with antecedent middle ear barotrauma (MEBt) common. IEBt includes perilymph fistula, intralabyrinthine membrane tear, inner ear haemorrhage and other rarer pathologies. Following a literature search, the pathophysiology, diagnosis, and treatment of IEBt in divers and best-practice recommendations for returning to diving were reviewed. Sixty-nine papers/texts were identified and 54 accessed. Twenty-five case series (majority surgical) provided guidance on diagnostic pathways; nine solely reported divers. IEBt in divers may be difficult to distinguish from inner ear decompression sickness (IEDCS), and requires dive-risk stratification and careful interrogation regarding diving-related ear events, clinical assessment, pure tone audiometry, a fistula test and electronystagmography (ENG). Once diagnosed, conservative management is the recommended first line therapy for IEBt. Recompression does not appear to cause harm if the diagnosis (IEBt vs IEDCS) is doubtful (limited case data). Exploratory surgery is indicated for severe or persisting vestibular symptoms or hearing loss, deterioration of symptoms, or lack of improvement over 10 days indicating significant pathology. Steroids are used, but without high-level evidence. It may be possible for divers to return to subaquatic activity after stakeholder risk acceptance and informed consent, provided: (1) sensorineural hearing loss is stable and not severe; (2) there is no vestibular involvement (via ENG); (3) high-resolution computed tomography has excluded anatomical predilection to IEBt and (4) education on equalising techniques is provided. There is a need for a prospective data registry and controlled trials to better evaluate diagnostic and treatment algorithms. Descriptors Links Book Title Database Publisher Data Source Authors Elliott,E.J., Smart,D.R. Original/Translated Title URL Date of Electronic PMCID Editors
The association between alcohol, marijuana use, and new and emerging tobacco products in a young adult population	2015	Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC, USA; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, USA. Electronic address: acohn@legacyforhealth.org.; Schroeder Institute for Tobacco Researc	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Sep Volume 48 Issue Start Page 79 Other Pages 88 Notes CI: Copyright (c) 2015; JID: 7603486; OTO: NOTNLM; 2014/08/28 [received]; 2015/01/27 [revised]; 2015/02/11 [accepted]; 2015/04/11 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1873-6327; 0306-4603 Accession Number PMID: 26042613 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.addbeh.2015.02.005 [doi] Output Language Unknown(0) PMID 26042613 Abstract BACKGROUND: Young adults have the highest rates of alcohol, tobacco, and other drug use relative to any other age group. Few studies have examined the co-occurrence of substance use with new and emerging tobacco products in this vulnerable group, or the underlying personality factors that may explain these associations. To address this gap, this study examined the association of current alcohol and marijuana use with the use of cigarettes and emerging tobacco products in a nationally representative sample of young adults. METHODS: Data were drawn from 18 to 24year olds in Wave 4 (January 2013; n=1609) of the Legacy Young Adult Cohort, a nationally-representative sample of men and women. Never, ever (lifetime), and past 30-day use of little cigars/cigarillos (LCCs), hookah, e-cigarettes, and cigarettes were assessed separately in current (everyday or some days) alcohol and marijuana users. RESULTS: Using weighted estimates, multivariable multinomial logistic regression models showed that current alcohol and marijuana use were associated with lifetime and past 30-day use of cigarettes, LCCs, e-cigarettes, and hookah, with different magnitudes of association found across each product. Post-hoc exploratory analyses showed that sensation-seeking traits moderated the relationship of alcohol (but not marijuana) use to current use of select tobacco products. DISCUSSION: Marijuana and alcohol use may enhance risk for emerging tobacco products use in young adulthood. Prevention and intervention programs may need to target poly-use of alcohol, marijuana, and tobacco rather than focusing on a single risk behavior during these critical years. Descriptors Links Book Title Database Publisher Elsevier Ltd Data Source Authors Cohn,A., Villanti,A., Richardson,A., Rath,J.M., Williams,V., Stanton,C., Mermelstein,R. Original/Translated Title URL Date of Electronic 20150411 PMCID Editors
The association between changes in alternative reinforcers and short-term smoking cessation	2014	Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: goelzp@mail.med.upenn.edu.; Department of Psychiatry, Perelman School of Medicine	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Drug and alcohol dependence Periodical, Abbrev. Drug Alcohol Depend. Pub Date Free Form 1-May Volume 138 Issue Start Page 67 Other Pages 74 Notes LR: 20150515; CI: Copyright (c) 2014; GR: DA025078/DA/NIDA NIH HHS/United States; GR: DA033681/DA/NIDA NIH HHS/United States; GR: P30 CA016520/CA/NCI NIH HHS/United States; GR: P50 CA143187/CA/NCI NIH HHS/United States; GR: P50CA143187/CA/NCI NIH HHS/Unit Place of Publication Ireland ISSN/ISBN 1879-0046; 0376-8716 Accession Number PMID: 24598122 Language eng SubFile Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1016/j.drugalcdep.2014.02.007 [doi] Output Language Unknown(0) PMID 24598122 Abstract BACKGROUND: While more than 50% of smokers make a serious quit attempt each year, less than 10% quit permanently. Evidence from studies of adolescent smoking and other substances of abuse suggest that alternative reinforcers, a construct of Behavioral Economic Theory, may contribute to the likelihood of smoking cessation in adults. This study examined the behavioral economics of smoking cessation within a smoking cessation clinical trial and evaluated how depressive symptoms and behavioral economic variables are associated with smoking cessation. METHODS: A sample of 469 smokers, enrolled in an effectiveness trial that provided counseling and 8 weeks of 21 mg nicotine patches, was analyzed. Alternative reinforcers (substitute and complementary reinforcers) and depressive symptoms were examined in relation to 7-day point prevalence abstinence, verified with breath carbon monoxide, 8 weeks after the quit date. RESULTS: Controlling for covariates associated with cessation (nicotine dependence, age of smoking initiation, patch adherence), participants who were abstinent at week 8 showed significantly higher substitute reinforcers at all time-points, compared to those who were smoking (p's<.05 participants="" who="" were="" abstinent="" at="" week="" showed="" lower="" complementary="" reinforcers="" and="" depressive="" symptoms="" all="" time-points="" compared="" to="" those="" smoking="" but="" significant="" differences="" confined="" there="" was="" no="" interaction="" between="" alternative="" across="" the="" weeks="" on="" abstinence.="" conclusions:="" these="" results="" support="" continued="" examination="" of="" behavioral="" economic="" theory="" in="" understanding="" adult="" cessation="" order="" inform="" future="" treatments="" guidelines.=""> Descriptors Links Book Title Database Publisher Elsevier Ireland Ltd Data Source Authors Goelz,P.M., Audrain-McGovern,J.E., Hitsman,B., Leone,F.T., Veluz-Wilkins,A., Jepson,C., Wileyto,E.P., D'Avanzo,P.A., Rivera,J.G., Schnoll,R.A. Original/Translated Title URL Date of Electronic 20140215 PMCID PMC4030632 Editors
The association between current low-dose oral contraceptive pills and periodontal health: a matched-case-control study	2010	Faculty of Dentistry at the Shahid Sadoughi University of Medical Sciences in Yazd, Iran.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The journal of contemporary dental practice Periodical, Abbrev. J.Contemp.Dent.Pract. Pub Date Free Form 1-May Volume 11 Issue 3 Start Page 33 Other Pages 40 Notes LR: 20151119; JID: 101090552; 0 (Contraceptives, Oral); epublish Place of Publication United States ISSN/ISBN 1526-3711; 1526-3711 Accession Number PMID: 20461322 Language eng SubFile Comparative Study; Journal Article; D; IM DOI 1526-3711-686 [pii] Output Language Unknown(0) PMID 20461322 Abstract AIM: This study assessed the influence of current oral contraceptive pills on periodontal health in young females. METHODS AND MATERIALS: Seventy women ranging in age from 17 to 35 years (mean 24 years) had a comprehensive periodontal examination. Their current and previous oral contraceptive pill use was assessed by a questionnaire. A periodontal assessment was performed that included recording the following: plaque index, gingival index, probing depth, and attachment level at six sites per tooth. The periodontal health of women taking birth control pills for at least two years was compared to that of women not taking an oral contraceptive. The control and test groups were matched for socioeconomic status, age, oral habits, occupation, and educational levels. RESULTS: Although there was no difference in plaque index levels between the two groups, current oral contraceptive pill users had higher levels of gingival inflammation and bleeding on probing. However, no significant differences were found regarding mean probing depths and attachment loss between the two groups. CONCLUSION: As birth control policies are advocated by most countries, and because oral contraceptives are the most widely used method for birth control, a need exists to assess the effects of oral contraceptives on the periodontal health of young women. Although additional studies are needed to better understand the mechanism of OC-induced gingivitis, female patients should be informed of the oral and periodontal side effects of OCs and the need for meticulous home care and compliance with periodontal maintenance. Descriptors Adolescent, Adult, Age Factors, Case-Control Studies, Contraceptives, Oral/therapeutic use, Dental Plaque Index, Educational Status, Female, Gingival Hemorrhage/classification, Gingivitis/classification, Humans, Occupations, Periodontal Attachment Loss/classification, Periodontal Diseases/classification/etiology, Periodontal Index, Periodontal Pocket/classification, Periodontium/drug effects, Social Class, Surveys and Questionnaires, Time Factors, Young Adult Links Book Title Database Publisher Data Source Authors Haerian-Ardakani,A., Moeintaghavi,A., Talebi-Ardakani,M. R., Sohrabi,K., Bahmani,S., Dargahi,M. Original/Translated Title URL Date of Electronic 20100501 PMCID Editors
The association between obesity and GERD: a review of the epidemiological evidence	2008	The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA. hasheme@bcm.tmc.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Digestive diseases and sciences Periodical, Abbrev. Dig.Dis.Sci. Pub Date Free Form Sep Volume 53 Issue 9 Start Page 2307 Other Pages 2312 Notes LR: 20140912; GR: R01 CA116845/CA/NCI NIH HHS/United States; GR: R01 CA116845-03/CA/NCI NIH HHS/United States; JID: 7902782; RF: 50; NIHMS176037; OID: NLM: NIHMS176037; OID: NLM: PMC2827866; 2008/05/23 [received]; 2008/06/18 [accepted]; 2008/07/24 [aheado Place of Publication United States ISSN/ISBN 0163-2116; 0163-2116 Accession Number PMID: 18651221 Language eng SubFile Journal Article; Meta-Analysis; Review; AIM; IM DOI 10.1007/s10620-008-0413-9 [doi] Output Language Unknown(0) PMID 18651221 Abstract The current epidemics of obesity and gastroesophageal reflux disease (GERD)-related disorders have generated much interest in studying the association between them. Results of multiple studies indicate that obesity satisfies several criteria for a causal association with GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. An increase in GERD symptoms has been shown to occur in individuals who gain weight but continue to have a body mass index (BMI) in the normal range, contributing to the epidemiological evidence for a possible dose-response relationship between BMI and increasing GERD. Data are less clear on the relationship between Barrett's esophagus (BE) and obesity. However, when considered separately, abdominal obesity seems to explain a considerable part of the association with GERD, including BE. Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications. Descriptors Barrett Esophagus/epidemiology/physiopathology, Body Mass Index, Esophageal Neoplasms/epidemiology/physiopathology, Esophagitis/epidemiology/physiopathology, Gastroesophageal Reflux/epidemiology/physiopathology, Humans, Obesity/epidemiology/physiopathology, Risk Factors Links Book Title Database Publisher Data Source Authors El-Serag,H. Original/Translated Title URL Date of Electronic 20080724 PMCID PMC2827866 Editors
The association between senior student tobacco use rate at school and alternative tobacco product use among junior students in Canadian secondary schools	2014	School of Public Health and Health Systems, University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, Canada.; School of Public Health and Health Systems, University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, Canada.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco induced diseases Periodical, Abbrev. Tob Induc Dis. Pub Date Free Form 1-May Volume 12 Issue 1 Start Page 8 Other Pages 9625-12-8. eCollection 2014 Notes LR: 20140512; JID: 101201591; OID: NLM: PMC4012246; OTO: NOTNLM; 2014 [ecollection]; 2014/04/02 [received]; 2014/04/25 [accepted]; 2014/05/01 [epublish]; epublish Place of Publication England ISSN/ISBN 2070-7266; 1617-9625 Accession Number PMID: 24808817 Language eng SubFile Journal Article DOI 10.1186/1617-9625-12-8 [doi] Output Language Unknown(0) PMID 24808817 Abstract BACKGROUND: The use of alternative tobacco products (ATPs) has grown in popularity among Canadian youth. This study examined the association between a school-level characteristic (the senior student tobacco use rate) and the current use of manufactured cigarettes, little cigars or cigarillos, cigars, roll-your-own cigarettes, smokeless tobacco (SLT), and a hookah among junior students. METHODS: This study used nationally representative Canadian data from 29,495 students in grades 9 to 12 as part of the 2010/2011 Youth Smoking Survey. For each ATP, we described rates of senior and junior tobacco use, calculated the variance attributed to school-level factors, and examined the association between the senior student (grades 11 and 12) tobacco use rate and the current use of each ATP among junior students (grades 9 and 10) while accounting for relevant student-level characteristics. SAS 9.3 was used for all analyses. RESULTS: Over half of schools sampled had senior students that reported using each ATP. School-level differences accounted for between 14.1% and 29.7% of the variability in ATP current use among junior students. Each one percent increase in the number of senior students at a school that currently use manufactured cigarettes, SLT, or a hookah was significantly independently associated with an increased likelihood that a junior student at that school currently used manufactured cigarettes (OR 1.04, 95% CI 1.01 to 1.06), SLT (OR 1.14, 95% CI 1.06 to 1.24), or a hookah (OR 1.09, 95% CI 1.03 to 1.14). CONCLUSIONS: Characteristics of the school environment a junior student attends appear to play an important role in ATP use, and tobacco control programs and policies should be designed to ensure that they include strategies to curb the use of all tobacco products. Additional evidence is needed for the impact of comprehensive school-based tobacco control approaches. Descriptors Links Book Title Database Publisher Data Source Authors Cole,A.G., Leatherdale,S.T. Original/Translated Title URL Date of Electronic 20140501 PMCID PMC4012246 Editors
The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from Phase Three of the ISAAC programme	2012	Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. e.mitchell@auckland.ac.nz	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Thorax Periodical, Abbrev. Thorax Pub Date Free Form Nov Volume 67 Issue 11 Start Page 941 Other Pages 949 Notes LR: 20151119; JID: 0417353; 2012/06/12 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3296; 0040-6376 Accession Number PMID: 22693180 Language eng SubFile Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; IM DOI 10.1136/thoraxjnl-2011-200901 [doi] Output Language Unknown(0) PMID 22693180 Abstract BACKGROUND: Exposure to parental smoking is associated with wheeze in early childhood, but in 2006 the US Surgeon General stated that the evidence is insufficient to infer a causal relationship between exposure and asthma in childhood and adolescents. AIMS: To examine the association between maternal and paternal smoking and symptoms of asthma, eczema and rhinoconjunctivitis. METHODS: Parents or guardians of children aged 6-7 years completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including maternal smoking in the child's first year of life, current maternal smoking (and amount) and paternal smoking. Adolescents aged 13-14 years self completed the questionnaires on these symptoms and whether their parents currently smoked. RESULTS: In the 6-7-year age group there were 220 407 children from 75 centres in 32 countries. In the 13-14-year age group there were 350 654 adolescents from 118 centres in 53 countries. Maternal and paternal smoking was associated with an increased risk of symptoms of asthma, eczema and rhinoconjunctivitis in both age groups, although the magnitude of the OR is higher for symptoms of asthma than the other outcomes. Maternal smoking is associated with higher ORs than paternal smoking. For asthma symptoms there is a clear dose relationship (1-9 cigarettes/day, OR 1.27; 10-19 cigarettes/day, OR 1.35; and 20+ cigarettes/day, OR 1.56). When maternal smoking in the child's first year of life and current maternal smoking are considered, the main effect is due to maternal smoking in the child's first year of life. There was no interaction between maternal and paternal smoking. CONCLUSIONS: This study has confirmed the importance of maternal smoking, and the separate and additional effect of paternal smoking. The presence of a dose-response effect relationship with asthma symptoms suggests that the relationship is causal, however for eczema and rhinoconjunctivitis causality is less certain. Descriptors Links Book Title Database Publisher Data Source Authors Mitchell,E.A., Beasley,R., Keil,U., Montefort,S., Odhiambo,J., ISAAC Phase Three Study Group Original/Translated Title URL Date of Electronic 20120612 PMCID Editors
The association of body mass index with Barrett's oesophagus	2005	Southern Arizona VA Healthcare System and University of Arizona Health Science Center, Tucson, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Alimentary Pharmacology & Therapeutics Periodical, Abbrev. Aliment.Pharmacol.Ther. Pub Date Free Form 15-Nov Volume 22 Issue 10 Start Page 1005 Other Pages 1010 Notes LR: 20160803; JID: 8707234; CIN: Aliment Pharmacol Ther. 2006 Apr 1;23(7):1027; author reply 1027-8. PMID: 16573806; ppublish Place of Publication England ISSN/ISBN 0269-2813; 0269-2813 Accession Number PMID: 16268976 Language eng SubFile Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI APT2674 [pii] Output Language Unknown(0) PMID 16268976 Abstract BACKGROUND: Obesity has been linked to gastro-oesophageal reflux disease symptoms and oesophageal adenocarcinoma; however, there is no published evidence for an association with Barrett's oesophagus. AIM: To investigate the association between obesity and Barrett's oesophagus. METHODS: We conducted a retrospective cross-sectional study of patients who underwent upper endoscopy at the Southern Arizona Veteran's Affairs Healthcare System between 1998 and 2004. We examined male patients without malignancy, with available information on weight and height. Based on endoscopic and histological findings, patients were classified as cases with Barrett's oesophagus or non-cases without Barrett's oesophagus. Multivariable logistic regression analysis was conducted to examine the association of body mass index and obesity with Barrett's oesophagus and Barrett's oesophagus length while adjusting for age and race. RESULTS: There were 65 cases with Barrett's oesophagus and 385 non-cases without Barrett's oesophagus. The mean body mass index was significantly higher in cases than in non-cases (29.8 vs. 28.0, P = 0.03). Cases had significantly greater mean weight than controls (206 lb vs. 190,P = 0.005). The proportions of cases with body mass index 25-30 and body mass index > or =30 were greater than those in non-cases (44.6% vs. 37.7%) and (40.0% vs. 33.5%), respectively (P = 0.08). In the multivariable logistic regression model adjusting for race and age, when compared with body mass index or =30. When examined as a continuous variable the adjusted odd ratio for each five-point increase in body mass index was 1.35 (95% confidence interval: 1.06-1.71, P = 0.01). The association between weight and Barrett's oesophagus was also statistically significant (adjusted odd ratio for each 10 pound increase = 1.10, 1.03-1.17, P =0.002). Among the 65 cases of Barrett's oesophagus, there was no correlation between the length of Barrett's oesophagus at the time of diagnosis and the body mass index (correlation coefficient = 0.03, P = 0.79). CONCLUSION: This retrospective cross-sectional study in male veterans shows that overweight is associated with a two-and-half-fold increased risk of Barrett's oesophagus. Larger studies of the underlying mechanism are warranted to better understand how and why obese patients are at greater risk for Barrett's oesophagus. Descriptors Adult, Aged, Aged, 80 and over, Barrett Esophagus/etiology, Body Mass Index, Epidemiologic Methods, Humans, Male, Middle Aged, Obesity/complications Links Book Title Database Publisher Data Source Authors Stein,D. J., El-Serag,H. B., Kuczynski,J., Kramer,J. R., Sampliner,R. E. Original/Translated Title URL Date of Electronic PMCID Editors

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