Image
WTS Database
The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title | Pub Year | Author Sort descending | SearchLink |
|---|---|---|---|
| A LC-MS/MS method for the determination of BADGE-related and BFDGE-related compounds in canned fish food samples based on the formation of [M+NH(4)](+) aducts | 2012 | Laboratorio de Salud Publica de Lugo, Conselleria de Sanidad, Xunta de Galicia, Rua Montevideo 9, 27001 Lugo, Spain. jose.manuel.miguez.mayo@sergas.es | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Food Chemistry
Periodical, Abbrev.
Food Chem.
Pub Date Free Form
1-Dec
Volume
135
Issue
3
Start Page
1310
Other Pages
1315
Notes
CI: Copyright (c) 2012; JID: 7702639; 0 (Benzhydryl Compounds); 0 (Epoxy Compounds); 0 (bisphenol F diglycidyl ether); F3XRM1NX4H (2,2-bis(4-glycidyloxyphenyl)propane); 2011/11/03 [received]; 2012/04/17 [revised]; 2012/05/25 [accepted]; 2012/06/07 [aheado
Place of Publication
England
ISSN/ISBN
0308-8146; 0308-8146
Accession Number
PMID: 22953859
Language
eng
SubFile
Evaluation Studies; Journal Article; IM
DOI
10.1016/j.foodchem.2012.05.099 [doi]
Output Language
Unknown(0)
PMID
22953859
Abstract
A new and simple liquid chromatography tandem mass-spectrometry method for the determination of different bisphenol A (BPA) derivatives such as bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their reaction products with water and hydrochloric acid in different fish food products was developed. The extraction procedure and the chromatographic conditions were optimised for complex food matrices such as fish products. Food samples were homogenised and extracted with a 1:1 solution of acetonitrile-hexane, the solvent was eliminated in a N(2) stream and the extract was reconstituted with 0.5mL of a 0.01M solution of ammonium formate. The sample solution obtained was directly measured by LC-MS/MS without any further purification under the developed conditions. The use of a mobile phase composed by ammonium formate-methanol in a binary gradient mode produced [M+NH(4)](+) aducts for the different BADGEs and BFDGEs. These aduct's fragmentations were employed for the LC-MS/MS quantification of BPA derivatives in canned fish samples. The results of the validation were appropriate: the method was linear for BADGE and its hydrolysed derivatives up to 1000mugkg(-1), for the remaining compounds linearity achieved up to 100mugkg(-1). Quantification limits were in the range 2-10mugkg(-1). RSD (intra and inter-day) was 6-12% and the recovery was comprised between 89% and 109%. Under the optimised conditions, the chromatographic separation was performed in 8min per sample. The method was applied to the determination of BADGE, BFDGE and their reaction products in different samples of canned fish from Spanish origin. Migration results obtained were in compliance with the EU regulations.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Ltd
Data Source
Authors
Miguez,J., Herrero,C., Quintas,I., Rodriguez,C., Gigosos,P.G., Mariz,O.C.
Original/Translated Title
URL
Date of Electronic
20120607
PMCID
Editors
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| Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B | 2014 | Laboratorio Especial de Micologia, Disciplina de Infectologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.; Laboratorio Especial de Micologia, Disciplina de Infectologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil; Departamento | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
PloS one
Periodical, Abbrev.
PLoS One
Pub Date Free Form
31-Oct
Volume
9
Issue
10
Start Page
e109553
Other Pages
Notes
LR: 20151029; JID: 101285081; 0 (Antifungal Agents); 0 (DNA, Ribosomal); 0 (Triazoles); 7XU7A7DROE (Amphotericin B); OID: NLM: PMC4215839; 2014 [ecollection]; 2014/05/09 [received]; 2014/07/30 [accepted]; 2014/10/31 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1932-6203; 1932-6203
Accession Number
PMID: 25360765
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1371/journal.pone.0109553 [doi]
Output Language
Unknown(0)
PMID
25360765
Abstract
Invasive infections caused by Trichosporon spp. have increased considerably in recent years, especially in neutropenic and critically ill patients using catheters and antibiotics. The genus presents limited sensitivity to different antifungal agents, but triazoles are the first choice for treatment. Here, we investigated the biofilm production and antifungal susceptibility to triazoles and amphotericin B of 54 Trichosporon spp. isolates obtained from blood samples (19), urine (20) and superficial mycosis (15). All isolates and 7 reference strains were identified by sequence analysis and phylogenetic inferences of the IGS1 region of the rDNA. Biofilms were grown on 96-well plates and quantitation was performed using crystal violet staining, complemented with Scanning Electron Microscopy (SEM). Susceptibility tests for fluconazole, itraconazole, voriconazole and amphotericin B were processed using the microdilution broth method (CLSI) for planktonic cells and XTT reduction assay for biofilm-forming cells. Our results showed that T. asahii was the most frequent species identified (66.7%), followed by T. faecale (11.1%), T. asteroides (9.3%), T. inkin (7.4%), T. dermatis (3.7%) and one T. coremiiforme (1.8%). We identified 4 genotypes within T. asahii isolates (G1, G3, G4 and G5) and 2 genotypes within T. faecale (G1 and G3). All species exhibited high adhesion and biofilm formation capabilities, mainly T. inkin, T. asteroides and T. faecale. Microscopy images of high biofilm-producing isolates showed that T. asahii presented mainly hyphae and arthroconidia, whereas T. asteroides exhibited mainly short arthroconidia and few filaments. Voriconazole exhibited the best in vitro activity against all species tested. Biofilm-forming cells of isolates and reference strains were highly resistant to all antifungals tested. We concluded that levels of biofilm formation by Trichosporon spp. were similar or even greater than those described for the Candida genus. Biofilm-forming cells were at least 1,000 times more resistant to antifungals than planktonic cells, especially to voriconazole.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Iturrieta-Gonzalez,I.A., Padovan,A.C., Bizerra,F.C., Hahn,R.C., Colombo,A.L.
Original/Translated Title
URL
Date of Electronic
20141031
PMCID
PMC4215839
Editors
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| Smoking in car: monitoring pollution of particulate matter, of organic volatile compounds and of carbon monoxide. The effect of opening the driver's window | 2010 | Laboratorio per ricerca sull'inquinamento da fumo passivo, Istituto nazionale dei tumori/SIMG-Societa italiana di medicina generale, Milano. ginverni@clavis.it | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Epidemiologia e prevenzione
Periodical, Abbrev.
Epidemiol.Prev.
Pub Date Free Form
Jan-Apr
Volume
34
Issue
2-Jan
Start Page
35
Other Pages
42
Notes
LR: 20131121; JID: 8902507; 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); 0 (Volatile Organic Compounds); 7U1EE4V452 (Carbon Monoxide); ppublish
Place of Publication
Italy
ISSN/ISBN
1120-9763; 1120-9763
Accession Number
PMID: 20595734
Language
ita
SubFile
Comparative Study; English Abstract; Journal Article; IM
DOI
183 [pii]
Output Language
Unknown(0)
PMID
20595734
Abstract
OBJECTIVE: to identify the most suitable marker for monitoring ETS inside a moving car, and to verify the efficacy of window opening to reduce ETS pollution inside the car. DESIGN: experimental pilot study. SSETTING AND PARTICIPANTS: monitoring of ETS markers in a moving car. MAIN OUTCOMES MEASURES: we used real time analyzers to measure: n particulate matter as mass (mug/m3, PM1, PM2.5, PM10); n suspended particle number (total number of particles sized >0.3 e >0.4 mum; n the number of particles with aerodynamic size between 0.3-0.4 mum in diameter; n total volatile organic compounds (TVOC); n carbon monoxide (CO). The recordings were carried out inside a car moving on the road at the speed of 50 km/h, with controlled conditions of temperature and relative humidity. RESULTS: after lighting a cigarette, with driver's window closed, the levels of all the pollutants increased dramatically, with peaks of 700 mug/m3 for PM2.5 and PM10, and of over 600,000 particles/ liter, while TVOC reached values up to 6,000 mug/m3 and CO up to 6 ppm. When a cigarette was lit with the window 1/4 open, excess pollution was promptly recorded, although with less intensity. With the window completely open, PM, TVOC and CO concentrations were hardly measurable as compared to background levels. On the contrary, particle number increased dramatically up to over 300,000/liter, mostly due to the submicrometric particle fraction in the range 0.3-0.4 mum. CONCLUSION: smoking just a cigarette inside a car represents an extremely high exposure to ETS. Partially opening the window is useless to prevent the accumulation of pollutants. Complete window opening is helpful to remove coarse PM and volatile pollutants, but is ineffective against submicrometer particles. Measuring particle number seems to be the best way to assess ETS pollution inside a car.
Descriptors
Air Movements, Air Pollution, Indoor/analysis, Automobile Driving, Automobiles, Carbon Monoxide/analysis, Environmental Monitoring/methods, Humans, Italy, Particulate Matter/analysis, Pilot Projects, Smoking, Tobacco Smoke Pollution/adverse effects/analysis, Volatile Organic Compounds/analysis, World Health Organization
Links
Book Title
Database
Publisher
Data Source
Authors
Invernizzi,G., Ruprecht,A. A., Mazza,R., De Marco,C., Tagliapietra,L., Michieletto,F., Allegri,F., Sbrogio,L., Boffi,R.
Original/Translated Title
Fumare in macchina: l'inquinamento da polveri, da composti organici volatili e da monossido di carbonio. L'effetto dell'apertura del finestrino
URL
Date of Electronic
PMCID
Editors
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| In vitro susceptibility of amphotericin-B, voriconazole and caspofungin against Candida guilliermondii biofilms, isolated from dentals units water pipes, under different growth phases | 2015 | Laboratory of Antibiotics Antifungals: physico-chemistry, synthesis and biological activity, Department of Biology, Tlemcen University, BP119 Imama, Tlemcen, Algeria. Electronic address: wissame85@yahoo.fr.; Laboratory of Antibiotics Antifungals: physico- | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal de mycologie medicale
Periodical, Abbrev.
J.Mycol.Med.
Pub Date Free Form
Mar
Volume
25
Issue
1
Start Page
57
Other Pages
62
Notes
CI: Copyright (c) 2014; JID: 9425651; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole); OTO: NOTNLM; 2014/08/22 [received]; 2014/10/01 [revised]; 2014/10/30 [accepted]; 2014/11/08 [
Place of Publication
France
ISSN/ISBN
1773-0449; 1156-5233
Accession Number
PMID: 25533329
Language
eng
SubFile
Journal Article; IM
DOI
10.1016/j.mycmed.2014.10.027 [doi]
Output Language
Unknown(0)
PMID
25533329
Abstract
OBJECTIVE: The dental units water pipes are a favorable medium for biofilms formation because of the small diameter of the pipe and the duration of water stagnation, but the question which arises is the nature of the biofilms which are formed inside? This article gives a progress report on the nature of this microbial contamination and precisely the fungal biofilms formation by examining their susceptibility to antifungal agents under different growth phases. METHODS: Sixteen samples of dental units water pipes were taken from public dental clinic and from stomatology unit at the university hospital of Tlemcen (Algeria). The isolated strains were identified by the conventional mycological methods and were analyzed to determine their minimal concentrations inhibiting their growth (planktonic and sessile forms) using three antifungal agents. RESULTS: Five strains type Candida guilliermondii were identified and analyzed for their resistance to antifungal agents. Antifungal susceptibility testing demonstrated the sensitivity of all planktonic Candida guilliermondii cells against amphotericin-B, voriconzole and caspofungin but the sessile cells of these strains revealed a less susceptibility to antifungal agents and even a resistance when the biofilm made mature. CONCLUSION: Several types of yeast contaminated the dental units water pipes and especially Candida guilliermondii that was the most founded. This specie was susceptible to antifungal agents under planctonic forms and resistance where the biofilm made mature.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Masson SAS
Data Source
Authors
Mazari,W., Boucherit-Otmani,Z., Boucherit,K.
Original/Translated Title
URL
Date of Electronic
20141108
PMCID
Editors
|
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| Main microorganisms involved in the fermentation of Ugandan ghee | 2009 | Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan. marongol@hotmail.com | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of food microbiology
Periodical, Abbrev.
Int.J.Food Microbiol.
Pub Date Free Form
15-Aug
Volume
133
Issue
3
Start Page
286
Other Pages
291
Notes
JID: 8412849; 0 (DNA, Bacterial); 0 (DNA, Fungal); 0 (Dietary Fats); 8029-34-3 (Butter); 2009/02/09 [received]; 2009/06/06 [revised]; 2009/06/08 [accepted]; 2009/06/17 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1879-3460; 0168-1605
Accession Number
PMID: 19577815
Language
eng
SubFile
Journal Article; IM
DOI
10.1016/j.ijfoodmicro.2009.06.003 [doi]
Output Language
Unknown(0)
PMID
19577815
Abstract
Ghee is widely produced from a traditional fermented butter-like product named mashita in western Uganda. However, no detailed studies have been done to identify the microorganisms involved in mashita fermentation. The aim of this study was to identify the microorganisms present at the end of mashita ripening using culture-dependent and culture-independent techniques. The most commonly identified species of lactic acid bacteria (LAB) in mashita using culture-dependent techniques were Lactobacillus paracasei, Lactobacillus helveticus, Lactobacillus plantarum and Lactobacillus perolens constituting 37.3%, 10.1%, 8.1% and 7.7% of total bacterial colonies isolated respectively. L. paracasei was the only bacterial species identified in all mashita samples by culture-dependent technique. Two of the four most commonly isolated LAB species (L. helveticus and L. plantarum) were also identified in mashita by a culture-independent method (PCR-DGGE). Other main LAB species identified in mashita by PCR-DGGE were Bifidobacterium sp., Enterococcus faecium, Lactobacillus brevis, Lactobacillus acetotolerans, Lactobacillus sp., Lactococcus raffinolactis, Lactococcus lactis subsp. lactis and Streptococcus salivarius. The main species of acetic acid bacteria (AAB) identified in the mashita using PCR-DGGE method were Acetobacter aceti, Acetobacter lovaniensis, Acetobacter orientalis and Acetobacter pasteurianus. PCR-DGGE identification of yeasts showed that Brettanomyces custersianus, Candida silvae, Geotrichum sp., Issatchenkia occidentalis, Issatchenkia orientalis, Kluyveromyces marxianus, Saccharomyces cerevisiae, and Trichosporon asahii were main yeast species in mashita. A. lovaniensis, A. aceti, and I. orientalis were identified in all the six mashita samples analyzed using PCR-DGGE method. Other microbial species were only found in some samples. These results indicate that LAB and yeasts, as in similar fermentation products, but also AAB are main microbial groups involved in mashita fermentation.
Descriptors
Bacteria/genetics/isolation & purification, Bacteriological Techniques/methods, Butter/microbiology, DNA, Bacterial, DNA, Fungal, Dietary Fats, Fermentation, Food Microbiology, Lactobacillus/genetics/isolation & purification, Sequence Analysis, DNA, Uganda, Yeasts/genetics/isolation & purification
Links
Book Title
Database
Publisher
Data Source
Authors
Ongol,M. P., Asano,K.
Original/Translated Title
URL
Date of Electronic
20090617
PMCID
Editors
|
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| Occurrence of bla CTX-M-1, qnrB1 and virulence genes in avian ESBL-producing Escherichia coli isolates from Tunisia | 2015 | Laboratory of Bacteriological Research, Institut de la Recherche Veterinaire de Tunis, Universite de Tunis El Manar Tunis, Tunisia ; LR99ES09 Laboratoire de Resistance aux Antimicrobiens, Faculte de Medecine de Tunis, Universite de Tunis El Manar Tunis, T | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Frontiers in cellular and infection microbiology
Periodical, Abbrev.
Front.Cell.Infect.Microbiol.
Pub Date Free Form
5-May
Volume
5
Issue
Start Page
38
Other Pages
Notes
LR: 20150527; JID: 101585359; 0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Escherichia coli Proteins); 0 (Qnr protein, E coli); 0 (Virulence Factors); EC 3.5.2.- (beta-lactamase TEM-3); EC 3.5.2.6 (beta-Lactamases); OID: NLM: PMC4419849; OTO: NOTNLM;
Place of Publication
Switzerland
ISSN/ISBN
2235-2988; 2235-2988
Accession Number
PMID: 26000252
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.3389/fcimb.2015.00038 [doi]
Output Language
Unknown(0)
PMID
26000252
Abstract
Avian ESBL-producing Escherichia coli isolates have been increasingly reported worldwide. Animal to human dissemination, via food chain or direct contact, of these resistant bacteria has been reported. In Tunisia, little is known about avian ESBL- producing E. coli and further studies are needed. Seventeen ESBL-producing Escherichia coli isolates from poultry feces from two farms (Farm 1 and farm 2) in the North of Tunisia have been used in this study. Eleven of these isolates (from farm 1) have the same resistance profile to nalidixic acid, sulfonamides, streptomycin, tetracycline, and norfloxacine (intermediately resistant). Out of the six isolates recovered from farm 2, only one was co-resistant to tetracycline. All isolates, except one, harbored bla CTX-M-1 gene, and one strain co-harbored the bla TEM-1 gene. The genes tetA and tetB were carried, respectively, by 11 and 1 amongst the 12 tetracycline-resistant isolates. Sulfonamides resistance was encoded by sul1, sul2, and sul3 genes in 3, 17, and 5 isolates, respectively. The qnrB1 was detected in nine strains, one of which co-harbored qnrS1 gene. The search for the class 1 and 2 integrons by PCR showed that in farm 1, class 1 and 2 integrons were found in one and ten isolates, respectively. In farm 2, class 1 integron was found in only one isolate, class 2 was not detected. Only one gene cassette arrangement was demonstrated in the variable regions (VR) of the 10 int2-positive isolates: dfrA1- sat2-aadA1. The size of the VR of the class 1 integron was approximately 250 bp in one int1-positive isolate, whereas in the second isolate, no amplification was observed. All isolates of farm 1 belong to the phylogroup A (sub-group A0). However, different types of phylogroups in farm 2 were detected. Each of the phylogroups A1, B22, B23 was detected in one strain, while the D2 phylogroup was found in 3 isolates. The virulence genes iutA, fimH, and traT were detected in 3, 7, and 3 isolates, respectively. Two types of gene combination were detected: iutA+fimH+traT in 3 isolates and iutA+fimH in one isolate. The isolates recovered in farm 1 showed the same profile of PFGE macro-restriction, while isolates of farm 2 presented unrelated PFGE patterns. We conclude that these avian ESBL-producing E. coli isolates show homo- and heterogenic genetic background and that plasmids harboring ESBL genes could be involved in the dissemination of this resistance phenotype.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Kilani,H., Abbassi,M.S., Ferjani,S., Mansouri,R., Sghaier,S., Ben Salem,R., Jaouani,I., Douja,G., Brahim,S., Hammami,S., Ben Chehida,N., Boubaker,I.B.
Original/Translated Title
URL
Date of Electronic
20150505
PMCID
PMC4419849
Editors
|
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| Pipeline materials modify the effectiveness of disinfectants in drinking water distribution systems | 2005 | Laboratory of Environmental Microbiology, Department of Environmental Health, National Public Health Institute, P.O. Box 95, FIN-70701, Kuopio, Finland. markku.lehtola@ktl.fi | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Water research
Periodical, Abbrev.
Water Res.
Pub Date Free Form
May
Volume
39
Issue
10
Start Page
1962
Other Pages
1971
Notes
LR: 20131121; JID: 0105072; 0 (Disinfectants); 0 (Plastics); 4R7X1O2820 (Chlorine); 789U1901C5 (Copper); 2004/04/28 [received]; 2004/12/29 [revised]; ppublish
Place of Publication
England
ISSN/ISBN
0043-1354; 0043-1354
Accession Number
PMID: 15869778
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
S0043-1354(05)00100-4 [pii]
Output Language
Unknown(0)
PMID
15869778
Abstract
We studied how pipe material can modify the effectiveness of UV- and chlorine disinfection in drinking water and biofilms. This study was done with two pipe materials: copper and composite plastic (polyethylene, PE) in a pilot scale water distribution network. UV-disinfection decreased viable bacterial numbers in the pilot waterworks and outlet water of pipes on average by 79%, but in biofilms its disinfecting effect was minor. Chlorine decreased effectively the microbial numbers in water and biofilms of PE pipes. In outlet water from copper pipes, the effect of chlorination was weaker; microbial numbers increased back to the level before chlorination within a few days. In the biofilms present in the copper pipes, chlorine decreased microbial numbers only in front of the pipeline. One reason for weaker efficiency of chlorine in copper pipes was that its concentration declined more rapidly in the copper pipes than in the PE pipes. These results means that copper pipes may require a higher chlorine dosage than plastic pipes to achieve effective disinfection of the pipes.
Descriptors
Biofilms/drug effects/growth & development/radiation effects, Chlorine/pharmacology, Copper/chemistry, Disinfectants/chemistry/pharmacology, Plastics/chemistry, Ultraviolet Rays, Water Microbiology, Water Purification/methods, Water Supply
Links
Book Title
Database
Publisher
Data Source
Authors
Lehtola,M. J., Miettinen,I. T., Lampola,T., Hirvonen,A., Vartiainen,T., Martikainen,P. J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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|||
| Effect of maternal tobacco smoking or exposure to second-hand smoke on the levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine of mother and the first urine of newborn | 2011 | Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Poznan, Poland. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Periodical, Abbrev.
J.Physiol.Pharmacol.
Pub Date Free Form
Jun
Volume
62
Issue
3
Start Page
377
Other Pages
383
Notes
LR: 20151119; JID: 9114501; 0 (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol); 0 (Biomarkers); 0 (Carcinogens); 0 (Nitrosamines); 0 (Pyridines); 0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine); AYI8EX34EU (Creatinine); K5161X06LL (Cotinine); 2011/04
Place of Publication
Poland
ISSN/ISBN
1899-1505; 0867-5910
Accession Number
PMID: 21893699
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
21893699
Abstract
Tobacco smoking during pregnancy is associated with a variety of negative consequences not only for the mother, but also for the developing fetus. Many studies have shown that carcinogens contained in tobacco smoke permeate across the placenta, and are found in fetus. The aim of the study was to determine the prenatal exposure to tobacco-specific carcinogenic N-nitrosamines on the basis of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine of smoking and second-hand smoke (SHS) exposed women and in the first urine of their newborns. A questionnaire documenting demographics and socio-economical data, smoking habits and exposure to SHS was completed by 121 delivering women near or at term. Maternal concentrations of cotinine and NNAL were measured in urine of the mother and the first urine of her newborn infant by liquid chromatography tandem mass spectrometry (LC/MS/MS). The mean concentration of cotinine was 439.2 ng/mg creatinine and NNAL concentration in urine of smoking women was 74.0 pg/mg creatinine, and for her newborn 78.6 pg/mg creatinine. Among mothers exposed to SHS, cotinine and NNAL mean concentration were 23.1 ng/mg creatinine, and 26.4 pg/mg creatinine. In newborns of SHS exposed mothers during pregnancy the mean concentration of NNAL was 34.1 pg/mg creatinine, respectively. Active tobacco smoking as well as passive exposure to smoking during pregnancy is an important source of tobacco specific N-nitrosamines to the fetuses as evidenced by increased concentrations of this carcinogen. Determination of NNAL in maternal urine samples can be a useful biomarker of prenatal exposure of newborn to carcinogenic nitrosamines.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Florek,E., Piekoszewski,W., Basior,A., Merritt,A.T., Mazela,J., Lechowicz,W., Kornacka,M.K., Kramer,L.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Molecular Characterization of Plasmids Encoding CTX-M beta-Lactamases and their Associated Addiction Systems Circulating Among Escherichia coli from Retail Chickens, Chicken Farms, and Slaughterhouses in Korea | 2016 | Laboratory of Food Safety and Evaluation, Department of Biotechnology, Korea University, Seoul 136-713, Republic of Korea.; Laboratory of Food Safety and Evaluation, Department of Biotechnology, Korea University, Seoul 136-713, Republic of Korea. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of microbiology and biotechnology
Periodical, Abbrev.
J.Microbiol.Biotechnol.
Pub Date Free Form
Feb
Volume
26
Issue
2
Start Page
270
Other Pages
276
Notes
JID: 9431852; OTO: NOTNLM; ppublish
Place of Publication
Korea (South)
ISSN/ISBN
1738-8872; 1017-7825
Accession Number
PMID: 26562691
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.4014/jmb.1507.07048 [doi]
Output Language
Unknown(0)
PMID
26562691
Abstract
Extended-spectrum beta-lactamases (ESBLs), particularly those of the CTX-M types, are the predominant resistance determinants of Escherichia coli that are rapidly spreading worldwide. To determine CTX-M types, E. coli isolates were collected from retail chickens (n = 390) and environmental samples from chicken farms (n = 32) and slaughterhouses (n = 67) in Korea. Fifteen strains harboring blaCTX-M genes were isolated from 358 E. coli isolates. The most common CTX-M type was eight of CTX-M-15, followed by six of CTX-M-1 and one of CTX-M- 14. The blaCTX-M genes were identified in the isolates from retail chickens (n = 9), followed by feces, water pipes, floors, and walls. Conjugations confirmed the transferability of the plasmids carrying blaCTX-M genes to the recipient E. coli J53 strain. Furthermore, eight addiction systems carried by the replicons in CTX-M types were confirmed. The dominant system was identified as ccdAB, vagCD, and pndAC in donor strains and transconjugants. The clonal relationship between the two strains carrying blaCTX-M genes indicates that E. coli may transmit from the farm to retail chickens, suggesting a possible public health risk. Our findings demonstrate that the detection of CTX-M types in E. coli isolates is important for tracking ESBL production in animals, and suggest linkage of multiple addiction systems in plasmids bearing blaCTX-M genes.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Jo,S.J., Woo,G.J.
Original/Translated Title
URL
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| Species-specific and drug-specific differences in susceptibility of Candida biofilms to echinocandins: characterization of less common bloodstream isolates | 2013 | Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Thessaloniki, Greece. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Antimicrobial Agents and Chemotherapy
Periodical, Abbrev.
Antimicrob.Agents Chemother.
Pub Date Free Form
Jun
Volume
57
Issue
6
Start Page
2562
Other Pages
2570
Notes
LR: 20150427; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 9HLM53094I (anidulafungin); F0XDI6ZL63 (caspofungin); R10H71BSWG (micafungin); OID: NLM: PMC3716187; 2013/03/25 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1098-6596; 0066-4804
Accession Number
PMID: 23529739
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1128/AAC.02541-12 [doi]
Output Language
Unknown(0)
PMID
23529739
Abstract
Candida species other than Candida albicans are increasingly recognized as causes of biofilm-associated infections. This is a comprehensive study that compared the in vitro activities of all three echinocandins against biofilms formed by different common and infrequently identified Candida isolates. We determined the activities of anidulafungin (ANID), caspofungin (CAS), and micafungin (MFG) against planktonic cells and biofilms of bloodstream isolates of C. albicans (15 strains), Candida parapsilosis (6 strains), Candida lusitaniae (16 strains), Candida guilliermondii (5 strains), and Candida krusei (12 strains) by XTT [2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] assay. Planktonic and biofilm MICs were defined as >/= 50% fungal damage. Planktonic cells of all Candida species were susceptible to the three echinocandins, with MICs of /= 32 mg/liter. In contrast, the MICs of all three echinocandins for C. albicans and C. krusei biofilms were relatively low (MICs = 1 mg/liter). While echinocandins exhibited generally high MICs against C. parapsilosis biofilms, MFG exhibited the lowest MICs against these isolates (4 mg/liter). A paradoxical growth effect was observed with CAS concentrations ranging from 8 to 64 mg/liter against C. albicans and C. parapsilosis biofilms but not against C. krusei, C. lusitaniae, or C. guilliermondii. While non-albicans Candida planktonic cells were susceptible to all echinocandins, there were drug- and species-specific differences in susceptibility among biofilms of the various Candida species, with C. lusitaniae and C. guilliermondii exhibiting profiles of high MICs of the three echinocandins.
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Authors
Simitsopoulou,M., Peshkova,P., Tasina,E., Katragkou,A., Kyrpitzi,D., Velegraki,A., Walsh,T.J., Roilides,E.
Original/Translated Title
URL
Date of Electronic
20130325
PMCID
PMC3716187
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