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Simplified and rapid determination of polychlorinated biphenyls, polybrominated diphenyl ethers, and polycyclic aromatic hydrocarbons in fish and shrimps integrated into a single method 2011 Institute of Chemical Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Chemistry and Analysis, Prague, Czech Republic.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Analytica Chimica Acta
Periodical, Abbrev.
Anal.Chim.Acta
Pub Date Free Form
30-Nov
Volume
707
Issue
2-Jan
Start Page
84
Other Pages
91
Notes
LR: 20131121; CI: Copyright (c) 2011; JID: 0370534; 0 (Halogenated Diphenyl Ethers); 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Water Pollutants, Chemical); DFC2HB4I0K (Polychlorinated Biphenyls); 2011/07/18 [received]; 2011/09/13 [revised]; 2011/09/14 [ac
Place of Publication
Netherlands
ISSN/ISBN
1873-4324; 0003-2670
Accession Number
PMID: 22027123
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.aca.2011.09.016 [doi]
Output Language
Unknown(0)
PMID
22027123
Abstract
In this study, a new rapid and flexible method for the simultaneous determination of 18 key representatives of polychlorinated biphenyls (PCBs), 7 polybrominated diphenyl ethers (PBDEs), and 32 polycyclic aromatic hydrocarbons (PAHs) in fish and shrimps by gas chromatography coupled to mass spectrometry (GC-MS) was developed and validated. A substantial simplification of sample processing prior to quantification step was achieved: after addition of water to homogenized sample, transfer of hydrophobic analytes into ethyl acetate was supported by added inorganic salts. Bulk fat, contained in crude organic extract obtained by partition, was subsequently removed on a silica minicolumn. This approach enabled to process six samples in less than 1h; moreover, the volume of an extraction solvent and consumption of other chemicals can be significantly reduced compared to, e.g., traditional Soxhlet extraction followed by gel permeation chromatography. The recoveries of target analytes were in the range of 73-120% even at the lowest spiking level (1 mug kg(-1)), repeatabilities (relative standard deviations, RSDs) ranged from 1 to 20%. Under optimized GC-MS conditions (time-of-flight mass analyzer, TOF), the limits of quantification (LOQs) were as follows: PCBs 0.1-0.5 mug kg(-1), PBDEs 0.5 mug kg(-1), and PAHs 0.05-0.25 mug kg(-1). Ambient mass spectrometry employing a direct analysis in real time (DART) ion source was shown as an effective tool for fat control in extract, which is needed during the method development and examination of unknown samples prior to the analysis. Further extension of a method scope by other similar analytes is easily possible.
Descriptors
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Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Kalachova,K., Pulkrabova,J., Drabova,L., Cajka,T., Kocourek,V., Hajslova,J.
Original/Translated Title
URL
Date of Electronic
20110919
PMCID
Editors
Pre- and postnatal parental smoking and wheeze in infancy: cross cultural differences. Avon Study of Parents and Children (ALSPAC) Study Team, European Longitudinal Study of Pregnancy and Childhood (ELSPAC) Co-ordinating Centre 2001 Institute of Child Health, University of Bristol, Royal Hospital for Sick Children, UK.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The European respiratory journal
Periodical, Abbrev.
Eur.Respir.J.
Pub Date Free Form
Aug
Volume
18
Issue
2
Start Page
323
Other Pages
329
Notes
LR: 20151119; JID: 8803460; 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
Denmark
ISSN/ISBN
0903-1936; 0903-1936
Accession Number
PMID: 11529291
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
11529291
Abstract
In longitudinal cohort studies, the relationships between prenatal and postnatal tobacco smoke exposure and infant wheezing illnesses were compared in two geographically defined populations in Avon, UK and Brno and Znojmo in the South Moravian Region of the Czech Republic. Pregnant females living in defined regions and with expected dates of delivery between defined dates were recruited. Females completed self-report questionnaires during pregnancy and when their infant was 6 months old. For this analysis, responses to questions about smoking during pregnancy, environmental tobacco smoke (ETS) exposure and reported wheezing illnesses of infants at 6 months after birth were used. Odds ratios for wheeze in relation to the smoking variables were calculated with adjustment for potential confounding effects. The prevalence of smoking during pregnancy was higher in Avon (17.5%) than the Czech Republic (7.1%). Exposure of infants to ETS during the first 6 months after birth was also reported to be higher in Avon (35.5%) than the Czech Republic (9.7%). The prevalence of reported wheezing by 6 months of age was 21.4% in Avon and 10.3% in Brno and Znojmo. In Avon, there was a significant relationship between infant wheeze and maternal smoking during pregnancy (odds ratio (95% confidence interval) 1.30 (1.09-1.56), p=0.004) but not with environmental exposure after birth (1.11 (0.98-1.25)). In contrast, in Brno and Znojmo in the Czech Republic, there was a significant relationship between infant wheeze and ETS exposure (1.66 (1.17-2.36), p=0.04) but not with maternal smoking during pregnancy (0.99 (0.64-1.55)). This study demonstrated an apparent difference in the associations between prenatal and postnatal tobacco smoke exposure and infant wheezing illnesses in two populations with different smoking prevalence. The relationships were independent of a number of potential confounding variables that have been associated with infant wheezing. Possible explanations of these observations include dose-related effects of prenatal and postnatal tobacco smoke exposure of infants.
Descriptors
Adult, Cross-Cultural Comparison, Cultural Characteristics, Czech Republic/epidemiology, Female, Great Britain/epidemiology, Humans, Infant, Longitudinal Studies, Male, Odds Ratio, Parents, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Sounds/etiology, Smoking/adverse effects, Surveys and Questionnaires, Tobacco Smoke Pollution/adverse effects
Links
Book Title
Database
Publisher
Data Source
Authors
Henderson,A. J., Sherriff,A., Northstone,K., Kukla,L., Hruba,D.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Experiences of a health team working in a new urban settlement area in Istanbul 1991 Institute of Child Health, University of Istanbul, Turkey.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of community health
Periodical, Abbrev.
J.Community Health
Pub Date Free Form
Oct
Volume
16
Issue
5
Start Page
251
Other Pages
258
Notes
LR: 20061115; JID: 7600747; OID: PIP: 070983; OID: POP: 00209887; OTO: PIP; GN: PIP: TJ: JOURNAL OF COMMUNITY HEALTH.; ppublish
Place of Publication
UNITED STATES
ISSN/ISBN
0094-5145; 0094-5145
Accession Number
PMID: 1955576
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM; J
DOI
Output Language
Unknown(0)
PMID
1955576
Abstract
A project aiming at creating a model for comprehensive maternal and child health care for urban underdeveloped areas was started in a new settlement area of migrants in the vicinity of Istanbul. The project had an impact on health care status, particularly among infants and children, but the results indicated that more effort was needed to reach the mothers. It was noted that building space and the appearance of the work place influenced the prestige of the team. Absentee problems could be partly surmounted by repeated home visits. Based on this experience, it was concluded that health services in underdeveloped areas need to be supported by non medical personnel to act as home visitors and as mediators between the community and the health team. It was also concluded that an established recording system to include both clinical data and attendance is needed to define the cases who need special care.; PIP: The purpose of this study was to establish a model of comprehensive health care for women and children in slum areas of urban cities in Turkey. The initial startup began in December 1986 with an area population and health survey. Prevention and curative services were initiated in March 1987. Poor attendance was a major problem. Group interviews were conducted in early 1988. In February 1989 a daily computerized record system was set up to identify risk groups and nonattenders. Home visits were conducted with a medically equipped mobile van; new facilities and staff were added. 26% of the district population of 9760 were women of reproductive age. 69% were married and 7.8% pregnant. 1267 infants and children between 0-60 months lived in the area of which 230 were 1 year. The area represented mainly skilled workers in nuclear families in houses that were in good condition. 51% had 5 years of schooling, 26% were illiterate, and 15.4% of husbands were illiterate. 59.6% of children, 20.4% of nonpregnant women, and 25% or pregnant women came for a 1st appointment albeit not at the scheduled date. Those not attending were found to go to private physicians, and believed that a free service cannot be good and criticized the physical accommodations. After home visits, attendance rose to 79.7% for infants, 61.8% for children, and 38.6% for women. Attendance over a 24 month period revealed that visits were higher than expected for infants and children. The program impact was a higher immunization rate/age (87% lacking immunization were immunized) and increased well baby care (83.1%). Maternal health improved and family planning users increased. The baseline survey showed 71.1% receiving antenatal care vs. 93.7% of the 147 currently pregnant women having received at least 1 visit in the 1-year survey. Hospital births also increased from a baseline of 58.8% to 78.3%. Family planning increased from 22.9% to 34.0% which included the preferred IUD. IUD users rose from 12.3% to 19.8% of married women of reproductive age. 47% of nonusers who had been pregnant in the past 2 years were now modern contraceptive users. Clinic utilization was enhanced by regular home visits by health workers, and quality of care. The appearance of the building space and comfortable surroundings also were important. Quality of care improvements are suggested over expansion. Community support is essential. Personnel need strong communication skills. Flexibility is needed to meet people's needs, and reevaluation is required.
Descriptors
Adult, Child Health Services, Child, Preschool, Comprehensive Health Care, Female, Health Promotion, Health Services Needs and Demand, Humans, Infant, Infant, Newborn, Male, Maternal Health Services, Patient Care Team, Pregnancy, Prenatal Care, Turkey, Urban Health, Asia, Communication, Data Collection, Delivery Of Health Care, Demographic And Health Surveys, Demographic Factors, Demographic Surveys, Developing Countries, Economic Factors, Examinations And Diagnoses, Health, Health Services, Health Services Evaluation, Home Visits, Interviews, Low Income Population, Maternal-child Health Services, Mediterranean Countries, Organization And Administration, Population, Population Characteristics, Population Dynamics, Primary Health Care, Program Acceptability, Program Appropriateness, Program Effectiveness, Program Evaluation, Programs, Quality Of Health Care, Research Methodology, Screening, Social Class, Socioeconomic Factors, Socioeconomic Status, Urban Population, Utilization Review, Western Asia
Links
Book Title
Database
Publisher
Data Source
Authors
Bulut,A., Uzel,N., Kutluay,T., Neyzi,O.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Ethnicity and waterpipe smoking among US students 2012 Institute of Community Health, College of Pharmacy, University of Houston, Houston, Texas 77030, USA. smabughosh@uh.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Periodical, Abbrev.
Int.J.Tuberc.Lung Dis.
Pub Date Free Form
Nov
Volume
16
Issue
11
Start Page
1551
Other Pages
1557
Notes
JID: 9706389; 2012/09/18 [aheadofprint]; ppublish
Place of Publication
France
ISSN/ISBN
1815-7920; 1027-3719
Accession Number
PMID: 23006908
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.5588/ijtld.12.0152 [doi]
Output Language
Unknown(0)
PMID
23006908
Abstract
OBJECTIVES: To examine the effect of ethnicity on waterpipe smoking among college students. DESIGN: A cross-sectional study utilized data from University of Houston students through an online survey (n = 2334) from March to April 2011. The survey included questions on demographic characteristics (sex, age, race/ethnicity), tobacco use experience, risk perception, social acceptability and popularity. Multivariate logistic regression was used to determine predictors of waterpipe use with three outcomes: ever-use vs. no use, past-year use vs. no use and past-month use vs. no use. RESULTS: Half of the sample had previously smoked tobacco using a waterpipe, approximately a third in the past year and 12.5% in the past month. Significant predictors included Middle Eastern ethnicity, Middle Eastern friend, past cigarette or cigar use. Perception of harm was associated with less use in the ever-use model, while perceived addictiveness, social acceptability and popularity of waterpipes were predictors in all models. CONCLUSION: Our findings underscore the importance of developing culturally appropriate interventions to control waterpipe smoking among Middle Eastern Americans and those of Indian/Pakistani descent to curb further spread in US society, and highlight the importance of developing interventions that target the perceived addictiveness, social acceptability and popularity of waterpipe smoking.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Abughosh,S., Wu,I.H., Peters,R.J., Hawari,F., Essien,E.J.
Original/Translated Title
URL
Date of Electronic
20120918
PMCID
Editors
Waterpipe smoking among students in one US university: predictors of an intention to quit 2012 Institute of Community Health, College of Pharmacy, University of Houston, Houston, TX 77030, USA. smabughosh@uh.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of American college health : J of ACH
Periodical, Abbrev.
J.Am.Coll.Health
Pub Date Free Form
Volume
60
Issue
7
Start Page
528
Other Pages
535
Notes
JID: 8214119; ppublish
Place of Publication
United States
ISSN/ISBN
1940-3208; 0744-8481
Accession Number
PMID: 23002801
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1080/07448481.2012.718018 [doi]
Output Language
Unknown(0)
PMID
23002801
Abstract
OBJECTIVE: To examine the intention to quit waterpipe smoking among college students. PARTICIPANTS: A total of 276 University of Houston students identified through an online survey administered in February 2011. Participants indicated they had smoked a waterpipe in the month prior to the survey. METHODS: Cross-sectional study. Questions included demographics, tobacco use, perceived risk of waterpipe smoking, and social acceptability. Multivariate logistic regression was used to determine predictors of an intention to quit. RESULTS: Most of the sample participants (n = 227; 83%) reported that they had no intention to quit. Students believing that waterpipe smoking was harmful were more likely to have an intention to quit (odd ratio [OR] = 2.38, 95% confidence interval [CI; 1.05, 5.36]). Those who smoked for more than 60 minutes were less likely to have a desire to quit (OR = 0.29, 95% CI [0.12, 0.73]). CONCLUSIONS: The low level of a desire to quit demonstrated underscores the urgent need to develop interventions that educate users about expected harms of continued use.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Abughosh,S., Wu,I.H., Rajan,S., Peters,R.J., Essien,E.J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Trends in incidence and prevalence of specialized intestinal metaplasia, barrett's esophagus, and adenocarcinoma of the gastroesophageal junction 2003 Institute of Digestive Diseases, Institut d'Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona Medical School, Villarroel 170, Barcelona 08036, Spain. mpera@medicina.ub.es
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
World journal of surgery
Periodical, Abbrev.
World J.Surg.
Pub Date Free Form
Sep
Volume
27
Issue
9
Start Page
999
Other Pages
1008; discussion 1006-8
Notes
LR: 20051116; JID: 7704052; RF: 83; 2003/08/18 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
0364-2313; 0364-2313
Accession Number
PMID: 12917764
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.1007/s00268-003-7052-2 [doi]
Output Language
Unknown(0)
PMID
12917764
Abstract
Most available information on the epidemiology of Barrettacute;s esophagus (BE) relates to patients with long segments (> 3 cm) of specialized intestinal metaplasia (SIM). Its prevalence is 3% in patients undergoing endoscopy for reflux symptoms and 1% in those undergoing endoscopy for any clinical indication. The latter prevalence is similar to the 1% found in autopsy series. A "silent majority" with BE remain unrecognized in the general population. BE is more common in men, and the prevalence rises with age. Recent endoscopic series document a rise in the diagnosis of endoscopically apparent short segments (< 3 cm) of BE (SSBE). The prevalence of SSBE in both unselected and reflux patients is 8% to 12%. Specialized intestinal metaplasia at the cardia, below a normal-appearing squamocolumnar junction, has been reported to vary from 6% to 25% in patients presenting for upper endoscopy. Unlike patients with long segment Barrett's esophagus (LSBE), the role of gastroesophageal reflux disease in the pathogenesis of SSBE and SIM of the cardia is controversial. Recent data suggest that the etiology of SIM of the cardia might be secondary to Helicobacter pylori infection, although the role of other environmental factors cannot be ruled out. The incidence of adenocarcinoma of the esophagus and esophagogastric juction (EGJ) has been increasing over the past 15 years in Western countries. Surgical series and population-based studies show that by 1994 adenocarcinomas of the esophagus accounted for half of all esophageal cancer among white men. LSBE and SSBE predispose to the development of adenocarcinoma of the esophagus and EGJ. The role of SIM of the cardia as a precursor lesion for EGJ adenocarcinoma is still unclear. The prevalences of dysplasia in LSBE and SSBE are around 6% and 8%, respectively. The incidence of adenocarcinoma in patients with LSBE is about 1 in 100 patient-years. Cancer risk for SSBE and SIM at the cardia is unknown. Smoking and obesity increase the risk for esophageal and EGJ adenocarcinomas.
Descriptors
Adenocarcinoma/epidemiology/etiology/pathology, Barrett Esophagus/epidemiology/etiology/pathology, Esophageal Neoplasms/epidemiology/etiology/pathology, Esophagogastric Junction/pathology, Humans, Incidence, Intestines/pathology, Metaplasia/epidemiology/etiology, Prevalence
Links
Book Title
Database
Publisher
Data Source
Authors
Pera,M.
Original/Translated Title
URL
Date of Electronic
20030818
PMCID
Editors
Determination of PAHs and BTEX in air in Zabrze City 2000 Institute of Environmental Engineering, Polish Academy of Science, Zabrze, Poland. misiek@ipis.zabrze.pl
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Central European journal of public health
Periodical, Abbrev.
Cent.Eur.J.Public Health
Pub Date Free Form
Jul
Volume
8 Suppl
Issue
Start Page
90
Other Pages
91
Notes
LR: 20131121; JID: 9417324; 0 (Air Pollutants); 0 (Benzene Derivatives); 0 (Polycyclic Compounds); 0 (Xylenes); 3FPU23BG52 (Toluene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene); ppublish
Place of Publication
CZECH REPUBLIC
ISSN/ISBN
1210-7778; 1210-7778
Accession Number
PMID: 10943488
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
10943488
Abstract
Descriptors
Air Pollutants/analysis, Benzene/analysis, Benzene Derivatives/analysis, Chromatography, Gas/methods, Poland, Polycyclic Compounds/analysis, Toluene/analysis, Xylenes/analysis
Links
Book Title
Database
Publisher
Data Source
Authors
Michalski,R., Weglarz,A., Skrok,R.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Personal exposure to volatile organic compounds in the Czech Republic 2012 Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of exposure science & environmental epidemiology
Periodical, Abbrev.
J.Expo.Sci.Environ.Epidemiol.
Pub Date Free Form
Sep
Volume
22
Issue
5
Start Page
455
Other Pages
460
Notes
LR: 20131121; JID: 101262796; 0 (Air Pollutants); 0 (Benzene Derivatives); 0 (Volatile Organic Compounds); 0 (Xylenes); 3FPU23BG52 (Toluene); 6WAC1O477V (4-xylene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene); O9XS864HTE (3-xylene); Z2474E14QP (2-xyle
Place of Publication
United States
ISSN/ISBN
1559-064X; 1559-0631
Accession Number
PMID: 22669500
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1038/jes.2012.30 [doi]
Output Language
Unknown(0)
PMID
22669500
Abstract
Personal exposures to volatile organic compounds (VOCs) were measured in the three industrial cities in the Czech Republic, Ostrava, Karvina and Havirov, while the city of Prague served as a control in a large-scale molecular epidemiological study identifying the impacts of air pollution on human health. Office workers from Ostrava and city policemen from Karvina, Havirov and Prague were monitored in the winter and summer of 2009. Only adult non-smokers participated in the study (N=160). Radiello-diffusive passive samplers were used to measure the exposure to benzene, toluene, ethylbenzene, meta- plus para-xylene and ortho-xylene (BTEX). All participants completed a personal questionnaire and a time-location-activity diary (TLAD). The average personal BTEX exposure levels in both seasons were 7.2/34.3/4.4/16.1 mug/m(3), respectively. The benzene levels were highest in winter in Karvina, Ostrava and Prague: 8.5, 7.2 and 5.3 mug/m(3), respectively. The personal exposures to BTEX were higher than the corresponding stationary monitoring levels detected in the individual localities (P
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Svecova,V., Topinka,J., Solansky,I., Sram,R.J.
Original/Translated Title
URL
Date of Electronic
20120606
PMCID
Editors
Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis 2001 Institute of Food Technology, University of Hohenheim, Stuttgart, Germany.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Applied and Environmental Microbiology
Periodical, Abbrev.
Appl.Environ.Microbiol.
Pub Date Free Form
Jun
Volume
67
Issue
6
Start Page
2578
Other Pages
2585
Notes
LR: 20140613; JID: 7605801; 0 (DNA Primers); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S); OID: NLM: PMC92910; ppublish
Place of Publication
United States
ISSN/ISBN
0099-2240; 0099-2240
Accession Number
PMID: 11375166
Language
eng
SubFile
Journal Article; IM
DOI
10.1128/AEM.67.6.2578-2585.2001 [doi]
Output Language
Unknown(0)
PMID
11375166
Abstract
Denaturing gradient gel electrophoresis (DGGE) of DNA fragments generated by PCR with 16S ribosomal DNA-targeted group-specific primers was used to detect lactic acid bacteria (LAB) of the genera Lactobacillus, Pediococcus, Leuconostoc, and Weissella in human feces. Analysis of fecal samples of four subjects revealed individual profiles of DNA fragments originating not only from species that have been described as intestinal inhabitants but also from characteristically food-associated bacteria such as Lactobacillus sakei, Lactobacillus curvatus, Leuconostoc mesenteroides, and Pediococcus pentosaceus. Comparison of PCR-DGGE results with those of bacteriological culture showed that the food-associated species could not be cultured from the fecal samples by plating on Rogosa agar. On the other hand, all of the LAB species cultured from feces were detected in the DGGE profile. We also detected changes in the types of LAB present in human feces during consumption of a milk product containing the probiotic strain Lactobacillus rhamnosus DR20. The analysis of fecal samples from two subjects taken before, during, and after administration of the probiotic revealed that L. rhamnosus was detectable by PCR-DGGE during the test period in the feces of both subjects, whereas it was detectable by culture in only one of the subjects.
Descriptors
Adult, Clinical Trials as Topic, DNA Primers, DNA, Ribosomal/genetics/isolation & purification, Electrophoresis/methods, Feces/microbiology, Female, Humans, Lactobacillaceae/genetics/isolation & purification, Lactobacillus/isolation & purification, Leuconostoc/isolation & purification, Male, Nucleic Acid Denaturation, Pediococcus/isolation & purification, Polymerase Chain Reaction/methods, Probiotics/pharmacology, RNA, Ribosomal, 16S/genetics/isolation & purification, Streptococcaceae/genetics/isolation & purification
Links
Book Title
Database
Publisher
Data Source
Authors
Walter,J., Hertel,C., Tannock,G. W., Lis,C. M., Munro,K., Hammes,W. P.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC92910
Editors
Effects of a guided web-based smoking cessation program with telephone counseling: a cluster randomized controlled trial 2014 Institute of General Practice, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany. michael.mehring@tum.de.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
24-Sep
Volume
16
Issue
9
Start Page
e218
Other Pages
Notes
LR: 20151029; JID: 100959882; OID: NLM: PMC4211026; OTO: NOTNLM; 2014/05/13 [received]; 2014/08/23 [accepted]; 2014/07/18 [revised]; epublish
Place of Publication
Canada
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 25253539
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.3536 [doi]
Output Language
Unknown(0)
PMID
25253539
Abstract
BACKGROUND: Preliminary findings suggest that Web-based interventions may be effective in achieving significant smoking cessation. To date, very few findings are available for primary care patients, and especially for the involvement of general practitioners. OBJECTIVE: Our goal was to examine the short-term effectiveness of a fully automated Web-based coaching program in combination with accompanied telephone counseling in smoking cessation in a primary care setting. METHODS: The study was an unblinded cluster-randomized trial with an observation period of 12 weeks. Individuals recruited by general practitioners randomized to the intervention group participated in a Web-based coaching program based on education, motivation, exercise guidance, daily short message service (SMS) reminding, weekly feedback through Internet, and active monitoring by general practitioners. All components of the program are fully automated. Participants in the control group received usual care and advice from their practitioner without the Web-based coaching program. The main outcome was the biochemically confirmed smoking status after 12 weeks. RESULTS: We recruited 168 participants (86 intervention group, 82 control group) into the study. For 51 participants from the intervention group and 70 participants from the control group, follow-up data were available both at baseline and 12 weeks. Very few patients (9.8%, 5/51) from the intervention group and from the control group (8.6%, 6/70) successfully managed smoking cessation (OR 0.86, 95% CI 0.25-3.0; P=.816). Similar results were found within the intent-to-treat analysis: 5.8% (5/86) of the intervention group and 7.3% (6/82) of the control group (OR 1.28, 95% CI 0.38-4.36; P=.694). The number of smoked cigarettes per day decreased on average by 9.3 in the intervention group and by 6.6 in the control group (2.7 mean difference; 95% CI -5.33 to -0.58; P=.045). After adjustment for the baseline value, age, gender, and height, this significance decreases (mean difference 2.2; 95% CI -4.7 to 0.3; P=.080). CONCLUSIONS: This trial did not show that the tested Web-based intervention was effective for achieving smoking cessation compared to usual care. The limited statistical power and the high drop-out rate may have reduced the study's ability to detect significant differences between the groups. Further randomized controlled trials are needed in larger populations and to investigate the long-term outcome. TRIAL REGISTRATION: German Register for Clinical Trials, registration number DRKS00003067; http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTM L&TRIAL_ ID=DRKS00003067 (Archived by WebCite at http://www.webcitation.org/6Sff1YZpx).
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Mehring,M., Haag,M., Linde,K., Wagenpfeil,S., Schneider,A.
Original/Translated Title
URL
Date of Electronic
20140924
PMCID
PMC4211026
Editors