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Effect of heavy metals and benzene on porphyrin synthesis of human epithelial larynx carcinoma cells (HEp-2) 2001 Herbarth, O., UFZ - Umweltforsch. Ztrm. L.-H. GmbH, Sekt. Expositionsforsch./Epidemiol., Medizinische Fak. der Univ. Leipzig, D-04318 Leipzig, Germany
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Print(0)
Ref Type
Journal Article
Periodical, Full
Umweltmedizin in Forschung und Praxis
Periodical, Abbrev.
Umweltmed.Forsch.Prax.
Pub Date Free Form
2001/
Volume
6
Issue
4
Start Page
221
Other Pages
230
Notes
Place of Publication
ISSN/ISBN
1430-8681
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Aim of the investigation was to prepare an environmental epidemiological test to detect the effects of pollutants by a pattern of porphyrin excretion in the urine. The task was to test whether lead, mercury, copper, zinc and benzene in environmentally relevant concentrations influence porphyrin synthesis of cells. The model used was the permanent epithelial larynx carcinoma cell line HEp-2, which was stimulated to synthesize porphyrins by adding δ-amino-levulinic acid (δ-ALA) in excess. 8- to 4-carboxyporphyrins and protoporphyrin IX were measured both in the cells and in the culture medium by means of high performance liquid cromatography (HPLC). The following pollutant effects were found: lead: extracellular increase of hexacarboxyporphyrin and intracellular decrease of heptacarboxy- and copro-porphyrin; mercury: extracellular decrease of heptacarboxyporphyrin and intracellular increase of coproporphyrin; copper: extracellular decrease of uro-, coproporphyrin and protoporphyrin IX, extracellular increase of heptacarboxyporphyrin and intracellular decrease of uro-, heptacarboxy- and coproporphyrin; zinc: extracellular increase of coproporphyrin; benzene: a tendency to extracellular increase of hexacarboxyporphyrin. The main result is the decrease in the concentrations of porphyrins caused by copper. This result is possibly linked to gastro-intestinal diseases among children due to drinking water from copper water pipes.
Descriptors
aminolevulinic acid, benzene, copper, heavy metal, lead, mercury, porphyrin, protoporphyrin, zinc, article, carcinoma cell, cell culture, culture medium, drinking, gastrointestinal disease, heme synthesis, high performance liquid chromatography, human, larynx carcinoma, pollutant, urinary excretion, water contamination
Links
Book Title
Wirkung von schwermetallen und benzol auf die porphyrinsynthese von humanen epithelialen larynxkarzinomzellen (HEp-2)
Database
Embase
Publisher
Data Source
Embase
Authors
Tumat,C., Kath,H. -G, Perlewitz,J., Herbarth,O., Manuwald,O.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Technical and economic criteria determining the rehabilitation and/or renewal of drinking water pipelines 1994 Herbert, H., Stadtwerke Innsbruck, A-6020 Innsbruck, Austria
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Water Supply
Periodical, Abbrev.
Water Supply
Pub Date Free Form
1994/
Volume
12
Issue
4-Mar
Start Page
105
Other Pages
117
Notes
Place of Publication
ISSN/ISBN
0735-1917
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
drinking water, conference paper, economics, pipeline, water treatment
Links
Book Title
Database
Embase
Publisher
Data Source
Embase
Authors
Herbert,H.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Phylogenetic analysis of a biofilm bacterial population in a water pipeline in the Gulf of Mexico 2006 Hernández-Rodríguez, C., Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, IPN, 06400 Mexico, D.F., Mexico
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
FEMS microbiology ecology
Periodical, Abbrev.
FEMS Microbiol.Ecol.
Pub Date Free Form
/
Volume
58
Issue
1
Start Page
145
Other Pages
154
Notes
Place of Publication
ISSN/ISBN
0168-6496; 1574-6941
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
The aim of this study was to assess the bacterial diversity associated with a corrosive biofilm in a steel pipeline from the Gulf of Mexico used to inject marine water into the oil reservoir. Several aerobic and heterotrophic bacteria were isolated and identified by 16S rRNA gene sequence analysis. Metagenomic DNA was also extracted to perform a denaturing gradient gel electrophoresis analysis of ribosomal genes and to construct a 16S rRNA gene metagenomic library. Denaturing gradient gel electrophoresis profiles and ribosomal libraries exhibited a limited bacterial diversity. Most of the species detected in the ribosomal library or isolated from the pipeline were assigned to Proteobacteria (Halomonas spp., Idiomarina spp., Marinobacter aquaeolei, Thalassospira sp., Silicibacter sp. and Chromohalobacter sp.) and Bacilli (Bacillus spp. and Exiguobacterium spp.). This is the first report that associates some of these bacteria with a corrosive biofilm. It is relevant that no sulfate-reducing bacteria were isolated or detected by a PCR-based method. The diversity and relative abundance of bacteria from water pipeline biofilms may contribute to an understanding of the complexity and mechanisms of metal corrosion during marine water injection in oil secondary recovery. © 2006 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved.
Descriptors
oil, RNA 16S, steel, aerobic bacterium, article, Bacilli, Bacillus, bacterial strain, bacterium identification, bacterium isolation, biofilm, Chromohalobacter, controlled study, corrosion, Exiguobacterium, gel electrophoresis, gene library, gene sequence, Halomonas, heterotrophy, marine environment, Marinobacter hydrocarbonoclasticus, Mexico, microbial diversity, nonhuman, nucleotide sequence, phylogeny, pipeline, polymerase chain reaction, priority journal, Proteobacteria, reservoir, ribosome, Silicibacter, Thalassospira, water analysis
Links
Book Title
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
López,M. A., Javier Zavala Díaz De La Serna,F., Jan-Roblero,J., Romero,J. M., Hernández-Rodríguez,C.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Levels of lead, cadmium, zinc and arsenic in the water in the province of Salamanca 1998 Hernandez, A.L.B., 37003 Salamanca, Spain
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Revista espanola de salud publica
Periodical, Abbrev.
Rev.Esp.Salud Publica
Pub Date Free Form
/
Volume
72
Issue
1
Start Page
53
Other Pages
65
Notes
Place of Publication
ISSN/ISBN
1135-5727
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Background: To establish the degree of contamination by lead, cadmium, zinc and arsenic in the water in Salamanca province and its relationship with the provenance of the samples and their collection point. Methods: Transverse, observational, descriptive epidemiological study. Province of Salamanca Results: Water from water pipes, fountains, springs, wells, rivers, streams and lakes in the province of Salamanca were studied, analyzing the lead, cadmium, zinc and arsenic contents of 180 samples using Atomic Absorption Spectroscopy. Results indicated that 56% of samples analyzed showed toxic levels of cadmium, and 28% of samples gave toxic levels of lead, but showed tolerable levels of zinc and arsenic. No major differences were observed in the degree of contamination by the four elements between the four provincial district areas. Levels of contamination by the four elements were compared for water from the water supply, and samples from wells, fountains, springs and surface water, showing similar contents of the elements studied. Conclusions: Findings suggest that the water in the province of Salamanca shows 'naturally' high cadmium and lead content, probably due to the geological characteristics of the terrain.
Descriptors
arsenic, cadmium, ground water, lake water, lead, river water, surface water, tap water, well water, zinc, article, atomic absorption spectrometry, lake, river, Spain, water contamination, water quality
Links
Book Title
Estudio de los niveles de plomo, cadmio, zinc y arsenico, en aguas de la provincia de Salamanca: Proyecto de investigacion coordinado multidepartamental subvencionado por la junta de castilla leon n. 1884
Database
Embase; MEDLINE
Publisher
Data Source
Embase
Authors
Blanco Hernández,A. L., Gutiérrez,D. A., De Blas,O. J., Guervós,M. S., De Miguel Manzano,B.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Online analysis of volatile organic compound emissions from Sitka spruce (Picea sitchensis) 2004 Hewitt, C.N., Inst. of Environ. and Nat. Sciences, Lancaster University, Lancaster, LA1 4YQ, United Kingdom
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Tree physiology
Periodical, Abbrev.
Tree Physiol.
Pub Date Free Form
/
Volume
24
Issue
7
Start Page
721
Other Pages
728
Notes
Place of Publication
ISSN/ISBN
0829-318X
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Volatile organic compound (VOC) emissions from Sitka spruce (Picea sitchensis Bong.) growing in a range of controlled light and temperature regimes were monitored online with a proton transfer reaction-mass spectrometer (PTR-MS) operating at a temporal resolution of ∼1 min. Isoprene emissions accounted for an average of more than 70% of measured VOCs and up to 3.5% of assimilated carbon. Emission rates (E) for isoprene correlated closely with photosynthetic photon flux (PPF) and temperature, showing saturation at a PPF of between 300 and 400 μmol m-2 s-1 and a maximum between 35 and 38°C. Under standard conditions of 30°C and 1000 μmol m -2 s-1 PPF, the mean isoprene E was 13 μg g dm-1 h-1, considerably higher than previously observed in this species. Mean E for acetaldehyde, methanol and monoterpenes at 30°C were 0.37, 0.78 and 2.97 μg gdm-1 h -1, respectively. In response to a sudden light to dark transition, isoprene E decreased exponentially by > 98% over about 3 h; however, during the first 7 min, this otherwise steady decay was temporarily but immediately depressed to ∼40% of the pre-darkness rate, before rallying during the following 7 min to rejoin the general downward trajectory of the exponential decay. The sudden sharp fall in isoprene E was mirrored by a burst in acetaldehyde E. The acetaldehyde E maximum coincided with the isoprene E minimum (7 min post-illumination), and ceased when isoprene emissions resumed their exponential decay. The causes of, and linkages between, these phenomena were investigated.
Descriptors
1,3 butadiene derivative, acetaldehyde, hemiterpene, isoprene, methanol, pentane, terpene, article, light, mass spectrometry, metabolism, physiology, spruce, temperature, tree
Links
Book Title
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Hayward,S., Tani,A., Owen,S. M., Hewitt,C. N.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Characteristics and risk factors of tobacco consumption among University of Sharjah students, 2005 2007 High Institute of Public Health, University of Alexandria, Alexandria, Egypt. ahmedmandil@hotmail.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
Periodical, Abbrev.
East.Mediterr.Health J.
Pub Date Free Form
Nov-Dec
Volume
13
Issue
6
Start Page
1449
Other Pages
1458
Notes
LR: 20151119; JID: 9608387; ppublish
Place of Publication
Egypt
ISSN/ISBN
1020-3397; 1020-3397
Accession Number
PMID: 18341194
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
18341194
Abstract
This study aimed to estimate the prevalence, patterns and risk factors of tobacco consumption among a stratified random sample of students at University of Sharjah, United Arab Emirates (UAE), during 2005. The overall reported smoking prevalence among 1057 sampled students was 15.1%; cigarette smokers were 9.4% and waterpipe smokers 5.6%. While women comprised only 8.9% of cigarette smokers, they were 26.2% of waterpipe smokers. Multiple linear regression analysis showed that the most important predictors for smoking among the students were: male sex, having a smoking friend, having a smoking family member (father/mother/both), non-UAE nationality and older age. There is a need to intensify efforts to prevent young people from starting smoking and to help young smokers to stop.
Descriptors
Adolescent, Adult, Age Distribution, Analysis of Variance, Attitude to Health, Cross-Sectional Studies, Family/psychology, Female, Friends/psychology, Health Surveys, Humans, Linear Models, Logistic Models, Male, Population Surveillance, Prevalence, Residence Characteristics/statistics & numerical data, Risk Factors, Sex Distribution, Smoking/epidemiology/prevention & control/psychology, Students/psychology/statistics & numerical data, Surveys and Questionnaires, United Arab Emirates/epidemiology, Universities
Links
Book Title
Database
Publisher
Data Source
Authors
Mandil,A., Hussein,A., Omer,H., Turki,G., Gaber,I.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Lower risk of decompression sickness after recommendation of conservative decompression practices in divers with and without vascular right-to-left shunt 2012 HNO-Praxis am Odeonsplatz, Brienner Strasse 13, 80333 Munchen, Germany. info@tauchersprechstunde.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Diving and hyperbaric medicine
Periodical, Abbrev.
Diving.Hyperb.Med.
Pub Date Free Form
Sep
Volume
42
Issue
3
Start Page
146
Other Pages
150
Notes
LR: 20141212; JID: 101282742; N762921K75 (Nitrogen); 2011/07/31 [received]; 2012/06/17 [accepted]; ppublish
Place of Publication
Australia
ISSN/ISBN
1833-3516; 1833-3516
Accession Number
PMID: 22987461
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
22987461
Abstract
INTRODUCTION: A vascular right-to-left shunt (r/l shunt) is a well-known risk factor for the development of decompression sickness (DCS). No studies to date have examined whether divers with a history of DCS with or without a r/l shunt have a reduced risk of suffering recurrent DCS when diving more conservative dive profiles (CDP). METHODS: Twenty-seven divers with a history of DCS recommended previously to dive more conservatively were included in this study and retrospectively interviewed by phone to determine the incidence of DCS recurrence. RESULTS: Twenty-seven divers performed 17,851 dives before examination in our department and 9,236 after recommendations for conservative diving. Mean follow up was 5.3 years (range 0-11 years). Thirty-eight events of DCS occurred in total, 34 before and four after recommendation of CDP. Four divers had a closure of their patent foramen ovale (PFO). A highly significant reduction of DCS risk was observed after recommendation of CDP for the whole group as well as for the sub-groups with or without a r/l shunt. A significant reduction of DCS risk in respect to r/l shunt size was also observed. DISCUSSION: This study indicates that recommendations to reduce nitrogen load after DCS appear to reduce the risk of developing subsequent DCS. This finding is independent of whether the divers have a r/l shunt or of shunt size. The risk of suffering recurrent DCS after recommendation for CDP is less than or equal to an unselected cohort of divers. CONCLUSION: Recommendation for CDP seems to significantly reduce the risk of recurrent DCS.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Klingmann,C., Rathmann,N., Hausmann,D., Bruckner,T., Kern,R.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
MCH released in a novel pheromone dispenser prevents spruce beetle, Dendroctonus rufipennis (Coleoptera: Scolytidae), attacks in south-central Alaska. 2003 Holsten, E.H., U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 3301 "C" St., Ste 200, Anchorage, Alaska 99503, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of economic entomology
Periodical, Abbrev.
J.Econ.Entomol.
Pub Date Free Form
/
Volume
96
Issue
1
Start Page
31
Other Pages
34
Notes
Place of Publication
ISSN/ISBN
0022-0493
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Field tests of 3-methyl-2-cyclohexen-1-one (MCH), the antiaggregation pheromone of the spruce beetle, Dendroctonus rufipennis Kirby, were conducted in south-central Alaska in stands of Lutz spruce, Picea x lutzii Little, and Sitka spruce, P. sitchensis (Bong.) Carr. The deployment of MCH in a novel releaser significantly reduced trap catches and spruce beetle attacks on standing live spruce by 96 and 87%, respectively. The results of this study demonstrate the first successful field test of MCH in Alaska for the prevention of spruce beetle attacks on standing, live spruce.
Descriptors
3 methyl 2 cyclohexen 1 one, 3-methyl-2-cyclohexen-1-one, cyclohexane derivative, pheromone, animal, article, beetle, biological pest control, devices, spruce, United States
Links
Book Title
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Holsten,E. H., Shea,P. J., Borys,R. R.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Temporal trends of esophageal disorders by age in the Cerner Health Facts database 2016 Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD. Electronic address: jessica.petrick@nih.gov.; Division of Gastroenterology, Department of Medicine, Hepatology and Nutrit
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annals of Epidemiology
Periodical, Abbrev.
Ann.Epidemiol.
Pub Date Free Form
Feb
Volume
26
Issue
2
Start Page
151
Other Pages
4.e1-4
Notes
LR: 20160426; CI: Published by Elsevier Inc.; GR: T32 DK007150/DK/NIDDK NIH HHS/United States; GR: T32DK007150/DK/NIDDK NIH HHS/United States; GR: UL1 TR000050/TR/NCATS NIH HHS/United States; GR: UL1TR00005/TR/NCATS NIH HHS/United States; GR: ZIA CP010220
Place of Publication
United States
ISSN/ISBN
1873-2585; 1047-2797
Accession Number
PMID: 26762962
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; IM
DOI
10.1016/j.annepidem.2015.11.004 [doi]
Output Language
Unknown(0)
PMID
26762962
Abstract
PURPOSE: Esophageal adenocarcinoma incidence has increased approximately 600% over the last 4 decades in the United States. Little research has been conducted on the temporal trends of gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), yet it is important to establish whether these conditions have also increased with time or differ by age. METHODS: The Cerner Health Facts((R)) database contains information on 35 million patients between 2001 and 2010. GERD, BE, and esophageal cancer (EC) cases were defined using International Classification of Diseases, ninth edition codes. We calculated age-adjusted rates and 95% confidence intervals for GERD, BE, and EC. RESULTS: In this population, the overall, all-age rate per 100,000 encounters for GERD was 711.9, BE was 21.6, and EC was 6.1. During 2001-2010, GERD rates increased by approximately 50% and EC rates more than doubled, but BE rates declined by approximately 40%. Trends were similar by age, and all rates were higher in Caucasians and males. CONCLUSIONS: These data indirectly support the idea that increased incidence of EC may be partially due to GERD and raise the provocative hypothesis that BE rates may be decreasing possibly as a forerunner of continued stabilization of esophageal adenocarcinoma rates and a possible subsequent decline.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Petrick,J.L., Nguyen,T., Cook,M.B.
Original/Translated Title
URL
Date of Electronic
20151211
PMCID
PMC4844025
Editors
Identification of a strawberry flavor gene candidate using an integrated genetic-genomic-analytical chemistry approach 2014 Horticultural Sciences Department, University of Florida, Gainesville, FL, USA. kfolta@ufl.edu.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
BMC genomics
Periodical, Abbrev.
BMC Genomics
Pub Date Free Form
17-Apr
Volume
15
Issue
Start Page
217
Other Pages
2164-15-217
Notes
LR: 20150806; JID: 100965258; 0 (Flavoring Agents); 0 (Lactones); 0 (Plant Proteins); 0 (Volatile Organic Compounds); 7HLS05KP9O (decan-4-olide); EC 1.14.19.- (Fatty Acid Desaturases); EC 1.14.99.- (delta-12 fatty acid desaturase); OID: NLM: PMC4023330; 2
Place of Publication
England
ISSN/ISBN
1471-2164; 1471-2164
Accession Number
PMID: 24742080
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1186/1471-2164-15-217 [doi]
Output Language
Unknown(0)
PMID
24742080
Abstract
BACKGROUND: There is interest in improving the flavor of commercial strawberry (Fragaria x ananassa) varieties. Fruit flavor is shaped by combinations of sugars, acids and volatile compounds. Many efforts seek to use genomics-based strategies to identify genes controlling flavor, and then designing durable molecular markers to follow these genes in breeding populations. In this report, fruit from two cultivars, varying for presence-absence of volatile compounds, along with segregating progeny, were analyzed using GC/MS and RNAseq. Expression data were bulked in silico according to presence/absence of a given volatile compound, in this case gamma-decalactone, a compound conferring a peach flavor note to fruits. RESULTS: Computationally sorting reads in segregating progeny based on gamma-decalactone presence eliminated transcripts not directly relevant to the volatile, revealing transcripts possibly imparting quantitative contributions. One candidate encodes an omega-6 fatty acid desaturase, an enzyme known to participate in lactone production in fungi, noted here as FaFAD1. This candidate was induced by ripening, was detected in certain harvests, and correlated with gamma-decalactone presence. The FaFAD1 gene is present in every genotype where gamma-decalactone has been detected, and it was invariably missing in non-producers. A functional, PCR-based molecular marker was developed that cosegregates with the phenotype in F1 and BC1 populations, as well as in many other cultivars and wild Fragaria accessions. CONCLUSIONS: Genetic, genomic and analytical chemistry techniques were combined to identify FaFAD1, a gene likely controlling a key flavor volatile in strawberry. The same data may now be re-sorted based on presence/absence of any other volatile to identify other flavor-affecting candidates, leading to rapid generation of gene-specific markers.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Chambers,A.H., Pillet,J., Plotto,A., Bai,J., Whitaker,V.M., Folta,K.M.
Original/Translated Title
URL
Date of Electronic
20140417
PMCID
PMC4023330
Editors