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WTS Database
The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title | Pub Year | Author | SearchLink Sort descending |
|---|---|---|---|
| Barrett esophagus in Asia: same disease with different pattern | 2014 | Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.; Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medi | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Clinical endoscopy
Periodical, Abbrev.
Clin.Endosc.
Pub Date Free Form
Jan
Volume
47
Issue
1
Start Page
15
Other Pages
22
Notes
LR: 20140624; JID: 101576886; OID: NLM: PMC3928486; OTO: NOTNLM; 2013/12/01 [received]; 2013/12/16 [revised]; 2014/01/02 [accepted]; 2014/01/24 [epublish]; ppublish
Place of Publication
Korea (South)
ISSN/ISBN
2234-2400; 2234-2400
Accession Number
PMID: 24570879
Language
eng
SubFile
Journal Article; Review
DOI
10.5946/ce.2014.47.1.15 [doi]
Output Language
Unknown(0)
PMID
24570879
Abstract
Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Lee,H.S., Jeon,S.W.
Original/Translated Title
URL
Date of Electronic
20140124
PMCID
PMC3928486
Editors
|
|||
| The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation | 2015 | MRC Cancer Unit, University of Cambridge Cambridge, UK.; MRC Cancer Unit, University of Cambridge Cambridge, UK.; MRC Cancer Unit, University of Cambridge Cambridge, UK.; MRC Cancer Unit, University of Cambridge Cambridge, UK.; MRC Cancer Unit, University | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Gut
Periodical, Abbrev.
Gut
Pub Date Free Form
Jan
Volume
64
Issue
1
Start Page
11
Other Pages
19
Notes
LR: 20160713; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; GR: 092096/Wellcome Trust/United Kingdom; GR: 098357/
Place of Publication
England
ISSN/ISBN
1468-3288; 0017-5749
Accession Number
PMID: 24572143
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; AIM; IM
DOI
10.1136/gutjnl-2013-306171 [doi]
Output Language
Unknown(0)
PMID
24572143
Abstract
OBJECTIVE: Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. We aimed to better understand these mechanisms by using a functional 3D approach. DESIGN: Proliferation, mitosis and the expression of progenitor lineage markers were assessed in normal squamous oesophagus from 10 patients by immunofluorescence on 3D epithelial whole mounts. Cells expressing differential levels of epithelial and progenitor markers were isolated using flow cytometry sorting and characterised by qPCR and IF. Their self-renewing potential was investigated by colony forming cells assays and in vitro organotypic culture models. RESULTS: Proliferation and mitotic activity was highest in the interpapillary basal layer and decreased linearly towards the tip of the papilla (p
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Barbera,M., di Pietro,M., Walker,E., Brierley,C., MacRae,S., Simons,B.D., Jones,P.H., Stingl,J., Fitzgerald,R.C.
Original/Translated Title
URL
Date of Electronic
20140226
PMCID
PMC4283695
Editors
|
|||
| The hazards of hospitals and selected public buildings of Legionella pneumophila | 2013 | Uniwersytet Medyczny w Lublinie, Katedra i Zaklad Mikrobiologii Lekarskiej. agnieszka.sikora24@wp.pl; Uniwersytet Medyczny w Lublinie, Katedra i Zaklad Mikrobiologii Lekarskiej.; Uniwersytet Medyczny w Lublinie, Katedra i Zaklad Mikrobiologii Lekarskiej.; | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Periodical, Abbrev.
Pol.Merkur Lekarski
Pub Date Free Form
Nov
Volume
35
Issue
209
Start Page
263
Other Pages
267
Notes
JID: 9705469; ppublish
Place of Publication
Poland
ISSN/ISBN
1426-9686; 1426-9686
Accession Number
PMID: 24575645
Language
pol
SubFile
English Abstract; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
24575645
Abstract
The registered infection and outbreaks of epidemic tend to monitor potential reservoirs of Legionella infection. According to the Act of 29 March 2007 on the requirements for the quality of water intended for human consumption are required to test for the presence and number of Legionella in the water system of hospitals. In case of detection of L. pneumophila serogroup 1 (SG 1) or increased above normal number other serogroups of bacteria it is necessary to eradicate these bacteria from the water system. The aim of this study was to assess the degree of contamination of the water supply system of selected public buildings and analyze the effectiveness of disinfection methods for the elimination of L. pneumophila in hot water systems. MATERIAL AND METHODS: The materials for this study were hot and cold water samples which were collected from the water supply system of 23 different objects. Enumeration of Legionella bacteria in water samples was determined by membrane filtration (FM) and/or by surface inoculation methods according to the standards: PN-ISO 11731: 2002: "The quality of the water. Detection and enumeration of Legionella" and PN-EN ISO 11731-2: 2008: "Water quality--Detection and enumeration of Legionella--Part 2: Methodology of membrane filtration for water with a small number of bacteria". RESULTS: L. pneumophila was present in 164 samples of hot water, which accounted for 76.99%. In all tested water samples L. pneumophila SG 2-14 strains were detected. The most virulent strain--L. pneumophila SG 1 was not detected. In examined 23 objects in 12 of L. pneumophila exceed acceptable levels > 100 CFU/100 ml. CONCLUSIONS: The presence of L. pneumophila SG 2-14 demonstrated in all examined objects, indicating the risk of infection, and the need for permanent monitoring of the water system supply. The thermal disinfection is the most common, inexpensive, and effective method of control of L. pneumophila used in examined objects, but does not eliminate bacterial biofilm. Disinfection using the filters stopped of L. pneumophila, and was the method of complementary thermal disinfection. Chlorine dioxide is a very effective biocide for large numbers of L. pneumophila in water systems.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Sikora,A., Koziol-Montewka,M., Wojtowicz-Bobin,M., Gladysz,I., Dobosz,P.
Original/Translated Title
Zagrozenia szpitali oraz wybranych obiektow uzytecznosci publicznej bakteriami Legionella pneumophila
URL
Date of Electronic
PMCID
Editors
|
|||
| Emerging nicotine delivery products. Implications for public health | 2014 | Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, the Departments of Medicine and of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Californi | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annals of the American Thoracic Society
Periodical, Abbrev.
Ann.Am.Thorac.Soc.
Pub Date Free Form
Feb
Volume
11
Issue
2
Start Page
231
Other Pages
235
Notes
LR: 20151119; JID: 101600811; 0 (Nicotinic Agonists); 6M3C89ZY6R (Nicotine); CIN: Ann Am Thorac Soc. 2014 Feb;11(2):216-9. PMID: 24575986; ppublish
Place of Publication
United States
ISSN/ISBN
2325-6621; 2325-6621
Accession Number
PMID: 24575992
Language
eng
SubFile
Journal Article; IM
DOI
10.1513/AnnalsATS.201312-433PS [doi]
Output Language
Unknown(0)
PMID
24575992
Abstract
The idea of clean nicotine delivery systems that would satisfy nicotine craving and promote smoking cessation has been considered as a possible public health tool for many years. Nicotine medications have been useful for smoking cessation but have not found widespread popularity among smokers, perhaps because of slow nicotine delivery and other sensory characteristics that differ from cigarettes. Traditional smokeless tobacco delivers as much nicotine as cigarettes and has been advocated for harm reduction but contains carcinogenic nitrosamines and has not been proven to promote cessation. Furthermore, there is concern that dual use of smokeless tobacco and cigarettes may inhibit quitting smoking. Newer oral dissolvable tobacco products contain lower levels of toxicants than other smokeless tobacco but also deliver much less nicotine and have not been popular with consumers. Electronic cigarettes that aerosolize nicotine without generating toxic tobacco combustion products have become quite popular and hold promise as a way to attract smokers away from cigarettes, although efficacy in promoting smoking cessation has not yet been demonstrated. There are concerns about safety of long-term use, and there is evidence that youth, including nonsmokers, are taking up e-cigarette use. E-cigarettes are marketed for use when one cannot smoke conventional cigarettes, and such use might result in more persistent cigarette smoking. Although their benefits and risks are being vigorously debated, e-cigarettes or other clean nicotine delivery devices could play an important role as an adjunct to a U.S. Food and Drug Administration regulatory intervention to make cigarettes less addictive and in this context could contribute to the end of cigarette smoking and smoking-induced disease.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Benowitz,N.L.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
|
|||
| Paradoxical antifungal activity and structural observations in biofilms formed by echinocandin-resistant Candida albicans clinical isolates | 2014 | University of New Mexico Health Science Center, Albuquerque. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Medical mycology
Periodical, Abbrev.
Med.Mycol.
Pub Date Free Form
Feb
Volume
52
Issue
2
Start Page
131
Other Pages
139
Notes
GR: T32 AI007538/AI/NIAID NIH HHS/United States; JID: 9815835; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); 0 (Membrane Proteins); 0 (Mutant Proteins); 9HLM53094I (anidulafungin); EC 2.4.1.- (Glucosyltransferases); F0XDI6ZL63 (caspofungin);
Place of Publication
England
ISSN/ISBN
1460-2709; 1369-3786
Accession Number
PMID: 24576999
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM
DOI
10.1093/mmy/myt007 [doi]
Output Language
Unknown(0)
PMID
24576999
Abstract
Echinocandin-resistant clinical isolates of Candida albicans have been reported, and key-hot spot mutations in the FKS1 gene, which encodes a major glucan synthase subunit, have been identified in these (caspofungin-resistant [CAS-R]) strains. Although these mutations result in phenotypic resistance to echinocandins in planktonic cells, there is little data on antifungal susceptibilities of CAS-R C. albicans strains within biofilms. Thus, we analyzed biofilms formed by 12 C. albicans CAS-R clinical strains in which we previously identified FKS1 hot-spot mutations and compared the sessile antifungal and paradoxical activity of anidulafungin (ANID), caspofungin (CAS), and micafungin (MICA). Biofilms were formed in a 96-well static microplate model and assayed using both tetrazolium-salt reduction and crystal violet assays, as well as examination by scanning electron microscopy. We first sought to assess biofilm formation and structure in these fks1 mutants and found that the biofilm mass and metabolic activities were reduced in most of the fks1 mutants as compared with reference strain SC5314. Structural analyses revealed that the fks1 mutant biofilms were generally less dense and had a clear predominance of yeast and pseudohyphae, with unusual "pit"-like cell surface structures. We also noted that sessile minimum inhibitory concentrations (MICs) to ANID, CAS, and MICA were higher than planktonic MICs of all but one strain. The majority of strains demonstrated a paradoxical effect (PE) to particular echinocandins, in either planktonic or sessile forms. Overall, biofilms formed by echinocandin-resistant clinical isolates demonstrated varied PEs to echinocandins and were structurally characterized by a preponderance of yeast, pseudohyphae, and pit-like structures.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Walraven,C.J., Bernardo,S.M., Wiederhold,N.P., Lee,S.A.
Original/Translated Title
URL
Date of Electronic
20131222
PMCID
Editors
|
|||
| Determinants of gastroesophageal reflux disease, including hookah smoking and opium use- a cross-sectional analysis of 50,000 individuals | 2014 | Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran ; The Tisch Cancer Institute and Institute for Transitional Epidemiology, Mount Sinai School of Medicine, New York, New York, Uni | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
PloS one
Periodical, Abbrev.
PLoS One
Pub Date Free Form
21-Feb
Volume
9
Issue
2
Start Page
e89256
Other Pages
Notes
LR: 20150813; GR: C20/A5860/Cancer Research UK/United Kingdom; GR: Intramural NIH HHS/United States; JID: 101285081; 8008-60-4 (Opium); OID: NLM: PMC3931722; 2014 [ecollection]; 2013/11/11 [received]; 2014/01/17 [accepted]; 2014/02/21 [epublish]; epublish
Place of Publication
United States
ISSN/ISBN
1932-6203; 1932-6203
Accession Number
PMID: 24586635
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; IM
DOI
10.1371/journal.pone.0089256 [doi]
Output Language
Unknown(0)
PMID
24586635
Abstract
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We investigated the factors associated with different measures of GERD symptoms, including frequency, patient-perceived severity, and onset time. METHODS: We performed a cross-sectional analysis of the baseline data from a population-based cohort study of approximately 50,000 individuals in in Golestan Province, Iran. GERD symptoms in this study included regurgitation and/or heartburn. RESULTS: Approximately 20% of participants reported at least weekly symptoms. Daily symptoms were less commonly reported by men, those of Turkmen ethnicity, and nass chewers. On the other hand, age, body mass index, alcohol drinking, cigarette smoking, opium use, lower socioeconomic status, and lower physical activity were associated with daily symptoms. Most of these factors showed similar associations with severe symptoms. Women with higher BMI and waist to hip ratio were more likely to report frequent and severe GERD symptoms. Hookah smoking (OR 1.34, 95% CI 1.02-1.75) and opium use (OR 1.70, 95% CI 1.55-1.87) were associated with severe symptoms, whereas nass chewing had an inverse association (OR 0.87, 95% CI 0.76-0.99). After exclusion of cigarette smokers, hookah smoking was still positively associated and nass chewing was inversely associated with GERD symptoms (all frequencies combined). CONCLUSION: GERD is common in this population. The associations of hookah and opium use and inverse association of nass use with GERD symptoms are reported for the first time. Further studies are required to investigate the nature of these associations. Other determinants of GERD were mostly comparable to those reported elsewhere.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Islami,F., Nasseri-Moghaddam,S., Pourshams,A., Poustchi,H., Semnani,S., Kamangar,F., Etemadi,A., Merat,S., Khoshnia,M., Dawsey,S.M., Pharoah,P.D., Brennan,P., Abnet,C.C., Boffetta,P., Malekzadeh,R.
Original/Translated Title
URL
Date of Electronic
20140221
PMCID
PMC3931722
Editors
|
|||
| Comparison of text and video computer-tailored interventions for smoking cessation: randomized controlled trial | 2014 | School for Public Health and Primary Care (CAPHRI), Department of Health Promotion, Maastricht University, Maastricht, Netherlands. nicola.stanczyk@maastrichtuniversity.nl. | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
3-Mar
Volume
16
Issue
3
Start Page
e69
Other Pages
Notes
LR: 20151119; NTR/NTR3102; JID: 100959882; OID: NLM: PMC3961744; OTO: NOTNLM; 2013/10/10 [received]; 2014/01/25 [accepted]; 2014/01/15 [revised]; epublish
Place of Publication
Canada
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 24589938
Language
eng
SubFile
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.3016 [doi]
Output Language
Unknown(0)
PMID
24589938
Abstract
BACKGROUND: A wide range of effective smoking cessation interventions have been developed to help smokers to quit. Smoking rates remain high, especially among people with a lower level of education. Multiple tailoring adapted to the individual's readiness to quit and the use of visual messaging may increase smoking cessation. OBJECTIVE: The results of video and text computer tailoring were compared with the results of a control condition. Main effects and differential effects for subgroups with different educational levels and different levels of readiness to quit were assessed. METHODS: During a blind randomized controlled trial, smokers willing to quit within 6 months were assigned to a video computer tailoring group with video messages (n=670), a text computer tailoring group with text messages (n=708), or to a control condition with short generic text advice (n=721). After 6 months, effects on 7-day point prevalence abstinence and prolonged abstinence were assessed using logistic regression analyses. Analyses were conducted in 2 samples: (1) respondents (as randomly assigned) who filled in the baseline questionnaire and completed the first session of the program, and (2) a subsample of sample 1, excluding respondents who did not adhere to at least one further intervention session. In primary analyses, we used a negative scenario in which respondents lost to follow-up were classified as smokers. Complete case analysis and multiple imputation analyses were considered as secondary analyses. RESULTS: In sample 1, the negative scenario analyses revealed that video computer tailoring was more effective in increasing 7-day point prevalence abstinence than the control condition (OR 1.45, 95% CI 1.09-1.94, P=.01). Video computer tailoring also resulted in significantly higher prolonged abstinence rates than controls among smokers with a low (ready to quit within 4-6 months) readiness to quit (OR 5.13, 95% CI 1.76-14.92, P=.003). Analyses of sample 2 showed similar results, although text computer tailoring was also more effective than control in realizing 7-day point prevalence abstinence. No differential effects were found for level of education. Complete case analyses and multiple imputation yielded similar results. CONCLUSIONS: In all analyses, video computer tailoring was effective in realizing smoking cessation. Furthermore, video computer tailoring was especially successful for smokers with a low readiness to quit smoking. Text computer tailoring was only effective for sample 2. Results suggest that video-based messages with personalized feedback adapted to the smoker's motivation to quit might be effective in increasing abstinence rates for smokers with diverse educational levels. TRIAL REGISTRATION: Netherlands Trial Register: NTR3102; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3102 (Archived by WebCite at http://www.webcitation.org/6NS8xhzUV).
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Stanczyk,N., Bolman,C., van Adrichem,M., Candel,M., Muris,J., de Vries,H.
Original/Translated Title
URL
Date of Electronic
20140303
PMCID
PMC3961744
Editors
|
|||
| Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers | 2014 | Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA; nadakassem@hotmail.com.; Center for Behavioral Epidemiology and Community Health, Graduate | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Jul
Volume
16
Issue
7
Start Page
961
Other Pages
975
Notes
LR: 20151119; CI: (c) The Author 2014; GR: CA-81301/CA/NCI NIH HHS/United States; GR: P30 DA012393/DA/NIDA NIH HHS/United States; GR: P30 DA012393/DA/NIDA NIH HHS/United States; GR: R01 CA138192-01A1/CA/NCI NIH HHS/United States; GR: R01HL103684-01A1/HL/N
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 24590387
Language
eng
SubFile
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ntr/ntu016 [doi]
Output Language
Unknown(0)
PMID
24590387
Abstract
INTRODUCTION: We examined homes of hookah-only smokers and nonsmokers for levels of indoor air nicotine (a marker of secondhand smoke) and indoor surface nicotine (a marker of thirdhand smoke), child uptake of nicotine, the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and the toxicant acrolein by analyzing their corresponding metabolites cotinine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and NNAL-glucuronides (total NNAL) and 3-hydroxypropylmercapturic acid. METHODS: Data were collected at 3 home visits during a 7-day study period from a convenience sample of 24 households with a child 5 years or younger. Three child urine samples and 2 air and surface samples from the living room and the child bedroom were taken in homes of nonsmokers (n = 5) and hookah-only smokers (n = 19) comprised of daily hookah smokers (n = 8) and weekly/monthly hookah smokers (n = 11). RESULTS: Nicotine levels in indoor air and on surfaces in the child bedrooms in homes of daily hookah smokers were significantly higher than in homes of nonsmokers. Uptake of nicotine, NNK, and acrolein in children living in daily hookah smoker homes was significantly higher than in children living in nonsmoker homes. Uptake of nicotine and NNK in children living in weekly/monthly hookah smoker homes was significantly higher than in children living in nonsmoker homes. CONCLUSIONS: Our data provide the first evidence for uptake of nicotine, the tobacco-specific lung carcinogen NNK, and the ciliatoxic and cardiotoxic agent acrolein in children living in homes of hookah smokers. Our findings suggest that daily and occasional hookah use in homes present a serious, emerging threat to children's long-term health.
Descriptors
Links
Book Title
Database
Publisher
. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco
Data Source
Authors
Kassem,N.O., Daffa,R.M., Liles,S., Jackson,S.R., Kassem,N.O., Younis,M.A., Mehta,S., Chen,M., Jacob,P.,3rd, Carmella,S.G., Chatfield,D.A., Benowitz,N.L., Matt,G.E., Hecht,S.S., Hovell,M.F.
Original/Translated Title
URL
Date of Electronic
20140303
PMCID
PMC4072898
Editors
|
|||
| Therapies against murine Candida guilliermondii infection, relationship between in vitro antifungal pharmacodynamics and outcome | 2015 | Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.; Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, | Read more... |
|
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Revista Iberoamericana De Micologia
Periodical, Abbrev.
Rev.Iberoam.Micol.
Pub Date Free Form
Jan-Mar
Volume
32
Issue
1
Start Page
34
Other Pages
39
Notes
CI: Copyright (c) 2013; JID: 9425531; 0 (Antifungal Agents); 0 (Echinocandins); 0 (liposomal amphotericin B); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); 9HLM53094I (anidulafungin); OTO: NOTNLM; 2013/07/11 [received]; 2013/10/09 [revised]; 2013
Place of Publication
Spain
ISSN/ISBN
2173-9188; 1130-1406
Accession Number
PMID: 24594291
Language
eng
SubFile
Journal Article; IM
DOI
10.1016/j.riam.2013.10.008 [doi]
Output Language
Unknown(0)
PMID
24594291
Abstract
BACKGROUND: Candida guilliermondii has been recognized as an emerging pathogen showing a decreased susceptibility to fluconazole and considerably high echinocandin MICs. AIMS: Evaluate the in vitro activity of anidulafungin in comparison to amphotericin B and fluconazole against different isolates of C. guilliermondii, and their efficacy in an immunosuppressed murine model of disseminated infection. METHODS: The in vitro susceptibility of four strains against amphotericin B, fluconazole and anidulafungin was performed by using a reference broth microdilution method and time-kill curves. The in vivo efficacy was evaluated by determination of fungal load reduction in kidneys of infected animals receiving deoxycholate AMB at 0,8 mg/kg i.v., liposomal amphotericin B at 10 mg/kg i.v., fluconazole at 50 mg/kg, or anidulafungin at 10 mg/kg. RESULTS: Amphotericin B and anidulafungin showed fungicidal activity, while fluconazole was fungistatic for all the strains. In the murine model, liposomal amphotericin B at 10 mg/kg/day was effective in reducing the tissue burden in kidneys of mice infected with any of the tested strains. However, amphotericin B, anidulafungin and fluconazole were only effective against those strains showing low MIC values. CONCLUSIONS: Liposomal amphotericin B showed the higher activity and efficacy against the two strains of C. guilliermondii, in contrast to the poor effect of fluconazole and anidulafungin. Further studies with more isolates of C. guilliermondii representing a wider range of MICs should be carried out to assess whether there is any relationship between MIC values and anidulafungin efficacy.
Descriptors
Links
Book Title
Database
Publisher
Revista Iberoamericana de Micologia. Published by Elsevier Espana
Data Source
Authors
Paredes,K., Pastor,F.J., Capilla,J., Sutton,D.A., Mayayo,E., Fothergill,A.W., Guarro,J.
Original/Translated Title
URL
Date of Electronic
20140301
PMCID
Editors
|
|||
| The association between changes in alternative reinforcers and short-term smoking cessation | 2014 | Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: goelzp@mail.med.upenn.edu.; Department of Psychiatry, Perelman School of Medicine | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Drug and alcohol dependence
Periodical, Abbrev.
Drug Alcohol Depend.
Pub Date Free Form
1-May
Volume
138
Issue
Start Page
67
Other Pages
74
Notes
LR: 20150515; CI: Copyright (c) 2014; GR: DA025078/DA/NIDA NIH HHS/United States; GR: DA033681/DA/NIDA NIH HHS/United States; GR: P30 CA016520/CA/NCI NIH HHS/United States; GR: P50 CA143187/CA/NCI NIH HHS/United States; GR: P50CA143187/CA/NCI NIH HHS/Unit
Place of Publication
Ireland
ISSN/ISBN
1879-0046; 0376-8716
Accession Number
PMID: 24598122
Language
eng
SubFile
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1016/j.drugalcdep.2014.02.007 [doi]
Output Language
Unknown(0)
PMID
24598122
Abstract
BACKGROUND: While more than 50% of smokers make a serious quit attempt each year, less than 10% quit permanently. Evidence from studies of adolescent smoking and other substances of abuse suggest that alternative reinforcers, a construct of Behavioral Economic Theory, may contribute to the likelihood of smoking cessation in adults. This study examined the behavioral economics of smoking cessation within a smoking cessation clinical trial and evaluated how depressive symptoms and behavioral economic variables are associated with smoking cessation. METHODS: A sample of 469 smokers, enrolled in an effectiveness trial that provided counseling and 8 weeks of 21 mg nicotine patches, was analyzed. Alternative reinforcers (substitute and complementary reinforcers) and depressive symptoms were examined in relation to 7-day point prevalence abstinence, verified with breath carbon monoxide, 8 weeks after the quit date. RESULTS: Controlling for covariates associated with cessation (nicotine dependence, age of smoking initiation, patch adherence), participants who were abstinent at week 8 showed significantly higher substitute reinforcers at all time-points, compared to those who were smoking (p's<.05 participants="" who="" were="" abstinent="" at="" week="" showed="" lower="" complementary="" reinforcers="" and="" depressive="" symptoms="" all="" time-points="" compared="" to="" those="" smoking="" but="" significant="" differences="" confined="" there="" was="" no="" interaction="" between="" alternative="" across="" the="" weeks="" on="" abstinence.="" conclusions:="" these="" results="" support="" continued="" examination="" of="" behavioral="" economic="" theory="" in="" understanding="" adult="" cessation="" order="" inform="" future="" treatments="" guidelines.="">
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Book Title
Database
Publisher
Elsevier Ireland Ltd
Data Source
Authors
Goelz,P.M., Audrain-McGovern,J.E., Hitsman,B., Leone,F.T., Veluz-Wilkins,A., Jepson,C., Wileyto,E.P., D'Avanzo,P.A., Rivera,J.G., Schnoll,R.A.
Original/Translated Title
URL
Date of Electronic
20140215
PMCID
PMC4030632
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