WTS database

Title	Pub Year	Author	SearchLink Sort ascending
The oral health status of postpartum mothers in South-East Hungary	2007	Department of Dentistry and Oral Surgery, Faculty of Medicine, University of Szeged, 6720 Szeged, Tisza L. krt. 64., Hungary. radnai@stoma.szote.u-szeged.hu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Community dental health Periodical, Abbrev. Community Dent.Health Pub Date Free Form Jun Volume 24 Issue 2 Start Page 111 Other Pages 116 Notes JID: 8411261; ppublish Place of Publication England ISSN/ISBN 0265-539X; 0265-539X Accession Number PMID: 17615827 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; D; IM DOI Output Language Unknown(0) PMID 17615827 Abstract OBJECTIVES: This study was carried out to assess the oral health status of new mothers, following not more than three days post-delivery, in South-East Hungary. An additional aim was to examine the effect of socioeconomic status on the oral health of the 169 women who volunteered, all of whom were healthy. MATERIAL AND METHODS: Socioeconomic data were collected via a questionnaire, and patients were examined according to WHO guidelines. The state of the periodontium was described by examining the plaque, calculus, probing depth and bleeding on probing. The mean age of the women was 27.5 yrs, representing all educational levels and professional categories of the country. RESULTS: The mean DMFT was 12.57, and the mean DMFS was 26.26. The plaque index was 0.68, the calculus frequency 20.22%, the mean probing depth 1.65mm and bleeding on probing occurred in 36.27% of teeth. Regression analyses demonstrated that caries levels were mostly related to age and plaque scores, while the state of the periodontium was mostly related to educational level, age and profession. The number of pregnancies had no significant influence on the caries nor on the periodontal status of these women. CONCLUSIONS: It was concluded that the oral health status of these mothers was mainly age- and socioeconomically-related, and that the dental needs of women during pregnancy must be emphasized, both to the dental profession and to the patients themselves. Descriptors Adolescent, Adult, Age Factors, Cross-Sectional Studies, DMF Index, Dental Calculus/classification, Dental Care, Dental Plaque/classification, Dental Plaque Index, Educational Status, Female, Gingival Hemorrhage/classification, Health Status, Humans, Hungary, Occupations, Oral Health, Parity, Periodontal Index, Periodontal Pocket/classification, Postpartum Period, Pregnancy, Social Class Links Book Title Database Publisher Data Source Authors Radnai,M., Gorzo,I., Nagy,E., Urban,E., Eller,J., Novak,T., Pal,A. Original/Translated Title URL Date of Electronic PMCID Editors
Antioxidant activity and cytotoxicity study of the flavonol glycosides from Bauhinia galpinii	2007	Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria. marogba@oauife.edu.ng	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Natural product research Periodical, Abbrev. Nat.Prod.Res. Pub Date Free Form Jun Volume 21 Issue 7 Start Page 591 Other Pages 599 Notes LR: 20091119; JID: 101167924; 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonols); 0 (Formazans); 0 (Glycosides); 0 (Hydrazines); 0 (Picrates); 0 (Tetrazolium Salts); 1898-66-4 (2,2-diphenyl-1-picrylhydrazyl); 23305-68-2 (MTT formazan); ppublish Place of Publication England ISSN/ISBN 1478-6419; 1478-6419 Accession Number PMID: 17613816 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 779728379 [pii] Output Language Unknown(0) PMID 17613816 Abstract The antioxidant activity of the crude extract and solvent fractions obtained from the leaves of Bauhinia galpinii was evaluated in terms of capacity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals. The crude extract and the more polar solvent fractions (ethyl acetate and butanol) showed considerable antioxidant activity. The antioxidant potential of the extracts, expressed as EC50, ranged between 28.85 +/- 1.28 microg mL(-1)and 118.16 +/- 6.41 microg mL(-1). L-Ascorbic acid was used as a standard (EC50 = 19.79 +/- 0.14 microM). Bioassay guided fractionation of the two active solvent fractions led to the isolation of three flavonoid glycosides, identified as: quercetin-3-O-galactopyranoside (1), myricetin-3-O-galactopyranoside (2), and 2''-O-rhamnosylvitexin (3). These compounds are reported for the first time from this species. The structures of the compounds were determined on the basis of spectral studies (1H NMR, 13C NMR and MS). Their antioxidant potential was evaluated using a DPPH spectrophotometric assay. Compound 2 had higher and 3 had lower antioxidant activity than L-ascorbic acid. No cytotoxic effects were displayed by compounds 1 and 3, but compound 2 was cytotoxic to Vero cells (LC50 = 74.68 microg mL(-1)) and bovine dermis cells (LC50 = 30.69 microg mL(-1)). Descriptors Animals, Antioxidants/chemistry/isolation & purification/pharmacology, Bauhinia/chemistry, Biphenyl Compounds/chemistry, Cattle, Cell Survival/drug effects, Cercopithecus aethiops, Flavonols/chemistry/isolation & purification/pharmacology, Formazans/metabolism, Glycosides/chemistry/isolation & purification/pharmacology, Hydrazines/chemistry, Mass Spectrometry, Nuclear Magnetic Resonance, Biomolecular, Picrates, Plant Leaves/chemistry, Plants, Medicinal/chemistry, Skin/cytology/drug effects, South Africa, Spectrophotometry, Ultraviolet, Tetrazolium Salts/metabolism, Vero Cells Links Book Title Database Publisher Data Source Authors Aderogba,M. A., McGaw,L. J., Ogundaini,A. O., Eloff,J. N. Original/Translated Title URL Date of Electronic PMCID Editors
Molecular identification of the microbiota of French sourdough using temporal temperature gradient gel electrophoresis	2007	Laboratoire de Microbiologie Alimentaire et Industrielle (LMAI), Unite de Recherche QM2A, ENITIAA, rue de la Geraudiere, BP 82225, 44322, Nantes Cedex 3, France. mounir.ferchichi@yahoo.fr	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Food Microbiology Periodical, Abbrev. Food Microbiol. Pub Date Free Form Oct-Dec Volume 24 Issue 8-Jul Start Page 678 Other Pages 686 Notes JID: 8601127; 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S); 2007/01/18 [received]; 2007/04/17 [revised]; 2007/04/19 [accepted]; 2007/05/03 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 0740-0020; 0740-0020 Accession Number PMID: 17613364 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI S0740-0020(07)00057-3 [pii] Output Language Unknown(0) PMID 17613364 Abstract The microbiota of four industrial French sourdoughs (BF, GO, VB and RF) was characterized by PCR temporal temperature gel electrophoresis (TTGE). The TTGE technique reveals differences in the 16S rDNA V6-V8 regions of these bacteria. DNA was extracted directly from sourdough samples. A specific TTGE fingerprint was determined for 30 bacterial species, including members of the genera Lactobacillus, Leuconostoc and Weissella, all known to be present in sourdough. These sourdoughs contain different species of lactic acid bacteria (LAB) depending on ecological conditions prevailing in the different sourdough fermentations. Only a few LAB species were found to be competitive and became dominant. Lactobacillus sanfranciscensis was observed as the most frequently found species. In sourdough GO, L. sanfranciscensis, Lactobacillus panis and two new species, Lactobacillus nantensis and Lactobacillus hammesii, were detected. Sourdough BF contain L. sanfranciscensis, Lactobacillus spicheri and Lactobacillus pontis. In sourdough VB, which differed in the process temperature, we identified exclusively L. sanfranciscensis and Leuconostoc mesenteroides subsp. mesenteroides. Lactobacillus frumenti, L. hammesii and Lacobacillus paralimentarius became the predominant species in sourdough RF. Compared with conventional bacteriological methods, the use of this new molecular approach to analyze the sourdough ecosystem should therefore allow a more complete and rapid assessment of its specific microbiota. Descriptors Bread/microbiology, Colony Count, Microbial, DNA, Bacterial/chemistry/genetics, DNA, Ribosomal/chemistry/genetics, Electrophoresis, Agar Gel/methods, Fermentation, Food Microbiology, Lactobacillus/classification/isolation & purification, Leuconostoc/classification/isolation & purification, Phylogeny, Polymerase Chain Reaction/methods, RNA, Ribosomal, 16S/chemistry/genetics, Species Specificity, Temperature Links Book Title Database Publisher Data Source Authors Ferchichi,M., Valcheva,R., Prevost,H., Onno,B., Dousset,X. Original/Translated Title URL Date of Electronic 20070503 PMCID Editors
Gender differences in smoking behavior among adolescents in Saudi Arabia	2007	Faculty of Medicine, King Fahad Medical City, College of Applied Medicine, King Saud University, PO Box 59048 Riyadh 11525, Kingdom of Saudi Arabia. Abdallaali63@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Saudi medical journal Periodical, Abbrev. Saudi Med.J. Pub Date Free Form Jul Volume 28 Issue 7 Start Page 1102 Other Pages 1108 Notes LR: 20141120; JID: 7909441; ppublish Place of Publication Saudi Arabia ISSN/ISBN 0379-5284; 0379-5284 Accession Number PMID: 17603720 Language eng SubFile Comparative Study; Journal Article; IM DOI 20060965' [pii] Output Language Unknown(0) PMID 17603720 Abstract OBJECTIVE: To describe and assess gender differences in current cigarette smokers' according to certain variables including prevalence, access to tobacco, knowledge and attitude, environmental tobacco smoke, cessation of smoking, tobacco related advertisements, and education on tobacco in school among adolescents in grades 7-12 in Tabuk, Saudi Arabia. METHODS: A random sample of schools in Tabuk city was obtained using a 2-stage cluster, in April 2005. A total of 16 governmental schools were selected. Within the schools, 48 classes were selected, targeting grades was 7 to 12. An anonymous, self-administered questionnaire was used to select 1,505 participants, with 96% response rate. RESULTS: Out of 1,505 students, 22.3% (34% males, 11.1% females) were current cigarette smokers (students who had smoked on one or more days in the 30 days preceding the survey), and 5.8% (11.1% males, 0.7% females) were daily smokers. There were significant gender differences concerning source of cigarettes, usual place of smoke, intensity of smoking, knowledge on addiction of tobacco, exposure to education on tobacco, attitudes, and exposure to tobacco smoke in public places. While no significant gender differences were found with respect to age of initiation, knowledge of health hazards of tobacco, exposure to media, desire to quit, or exposure to tobacco smoke at home. CONCLUSION: For the suppression of the use of tobacco by adolescents in Saudi Arabia differential intervention strategies and policies in males and females are needed, such as reducing youth access to cigarettes-in addition to intensive school and community anti-tobacco programs. Descriptors Adolescent, Child, Female, Humans, Male, Psychology, Adolescent, Saudi Arabia, Sex Factors, Smoking, Smoking Cessation Links Book Title Database Publisher Data Source Authors Abdalla,A. M., Al-Kaabba,A. F., Saeed,A. A., Abdulrahman,B. M., Raat,H. Original/Translated Title URL Date of Electronic PMCID Editors
Quit attempts and intention to quit cigarette smoking among young adults in the United States	2007	Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7337, USA. faganp@mail.nih.gov	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Public Health Periodical, Abbrev. Am.J.Public Health Pub Date Free Form Aug Volume 97 Issue 8 Start Page 1412 Other Pages 1420 Notes LR: 20140904; GR: N01-CO-12400/CO/NCI NIH HHS/United States; JID: 1254074; OID: NLM: PMC1931471; 2007/06/28 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1541-0048; 0090-0036 Accession Number PMID: 17600244 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; AIM; IM DOI AJPH.2006.103697 [pii] Output Language Unknown(0) PMID 17600244 Abstract OBJECTIVES: We investigated variables associated with quitting behaviors among current, daily, and nondaily young adult smokers in the United States. METHODS: Data from the national 2003 Tobacco Use Special Cessation Supplement to the Current Population Survey were analyzed to identify factors associated with quit attempts and serious intention to quit among young adult smokers aged 18 to 30 years (n=7912). RESULTS: Daily smokers who smoked 20 or more cigarettes per day, had their first cigarette within 30 minutes of waking, and smoked no usual type were less likely than were their comparison groups to have 1 more or quit attempts. Nondaily smokers who were male, Hispanic, and smoked no usual type of cigarette were also less likely than were their comparison groups to report 1 or more quit attempts. Although unemployed nondaily smokers were more likely than were the employed to report intention to quit, nondaily smokers with an annual family income of $25,000 to $49,000 were less likely than were higher-income families to report intention to quit. CONCLUSIONS: Nicotine dependence measures were significantly associated with quitting and intention to quit among daily smokers, but sociodemographics were associated with quitting and intention to quit among nondaily smokers. Descriptors Adolescent, Adult, Cross-Sectional Studies, Female, Health Behavior, Humans, Intention, Logistic Models, Male, Multivariate Analysis, Prevalence, Smoking/epidemiology/prevention & control/psychology, Smoking Cessation/ethnology/psychology/statistics & numerical data, Socioeconomic Factors, United States/epidemiology Links Book Title Database Publisher Data Source Authors Fagan,P., Augustson,E., Backinger,C. L., O'Connell,M. E., Vollinger,R. E.,Jr, Kaufman,A., Gibson,J. T. Original/Translated Title URL Date of Electronic 20070628 PMCID PMC1931471 Editors
Rethinking postpartum family planning	1991	Population Council, New York, NY 10017.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Studies in family planning Periodical, Abbrev. Stud.Fam.Plann. Pub Date Free Form Sep-Oct Volume 22 Issue 5 Start Page 294 Other Pages 307 Notes LR: 20051116; JID: 7810364; RF: 57; OID: IND: 8019698; OID: PIP: 069243; OID: POP: 00206738; OTO: PIP; GN: PIP: TJ: STUDIES IN FAMILY PLANNING.; ppublish Place of Publication UNITED STATES ISSN/ISBN 0039-3665; 0039-3665 Accession Number PMID: 1759275 Language eng SubFile Journal Article; Review; IM; J DOI Output Language Unknown(0) PMID 1759275 Abstract This article examines the rationales for commonly advocated postpartum family planning services and challenges the behavioral and biological assumptions on which they are based. An alternative approach to service delivery is suggested. Services should be designed to incorporate breastfeeding and to increase their acceptability to postpartum women.; PIP: Postpartum is considered conceptually muddy, since the definition varies with its use, even within family planning programs; the context within this article is after childbirth. Postpartum programs to provide contraceptive information and supplies after childbirth are an accepted part of family planning service delivery. The objective of this article is to review the underpinnings of the postpartum service delivery model. Demographic implications are discussed based on empirical and simulation studies; the assumptions that women are most receptive to contraceptive programs at the time of childbirth, and that women will not generally return for services are discussed in terms of descriptions of women's contraceptive behavior in the postpartum period (survey and program information). Another objective is to discuss recent findings on the effects of breastfeeding on fertility and the implications for postpartum programs. A reexamination of women's needs is suggested. Studies discussed in the demographic implications sections pertain to postpartum ovulation and menstruation, the use of oral contraceptives during lactational amenorrhea, and studies of the duplication of protection. Various simulation models of the timing of postpartum contraceptive use are described, but none deals with whether women are more motivated to practice contraception just after childbirth, or whether women find it difficult to return for services after leaving a health facility. Attitudinal data are missing and are needed on postpartum motivation to contracept. Initiation after a recent birth may be based on her amenorrheic and breastfeeding status, the infant's developmental level, household or extra household activities, or the appropriate age at which the child may be left with others. The scarce data on the timing of contraceptive use indicates that women not menstruating were less likely to use contraception. The 1987 Thailand survey showed that 14% of women returned to nonpermanent methods prior to the return of menses, and 32% in the month immediately after the return of menses. This pattern may reflect the practices of family planning providers. Multivariate analyses support the inverse relationship between breastfeeding and use of contraception. In the returning to services issue, models do not tell whether availability of full services for well baby care and postpartum and contraceptive care would improve returns. The International Postpartum Program reveals some patterns. Future research agendas should focus on experiments to test different options for mother and baby care, and to test options and timing of their initiation. Descriptors Attitude to Health, Birth Intervals, Breast Feeding, Contraception Behavior, Family Planning Services/organization & administration/standards, Female, Fertility, Humans, Models, Psychological, Motivation, Patient Acceptance of Health Care, Postnatal Care/organization & administration/psychology/standards, Acceptors--women, Behavior, Contraception, Contraceptive Methods Chosen, Contraceptive Usage, Developing Countries, Economic Factors, Family Planning, Family Planning Programs, Health, Infant Nutrition, Literature Review, Marketing, Method Acceptability, Nutrition, Postpartum Amenorrhea, Postpartum Programs, Promotion, Psychological Factors, Puerperium, Reproduction Links Book Title Database Publisher Data Source Authors Winikoff,B., Mensch,B. Original/Translated Title URL Date of Electronic PMCID Editors
Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species	2007	Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Sep Volume 51 Issue 9 Start Page 3081 Other Pages 3088 Notes LR: 20140904; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Tetrazolium Salts); 117038-70-7 (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazoliu m hydroxide); F0XDI6ZL63 (caspofungin); OID: NLM: PMC2043224; 2007/0 Place of Publication United States ISSN/ISBN 0066-4804; 0066-4804 Accession Number PMID: 17591847 Language eng SubFile Journal Article; IM DOI AAC.00676-07 [pii] Output Language Unknown(0) PMID 17591847 Abstract The paradoxical growth (PG) of Candida sp. biofilms in the presence of high caspofungin (CAS) concentrations was previously unknown. We sought to characterize the PG at supra-MICs of CAS among clinical Candida sp. isolates grown as biofilms in 96-well polystyrene microtiter plates. The MICs of CAS were determined for 30 clinical Candida sp. isolates (4 Candida albicans, 6 C. tropicalis, 7 C. parapsilosis, 8 C. orthopsilosis, and 5 C. metapsilosis isolates) when they were grown as planktonic cells and biofilms and were defined as the lowest drug concentrations that resulted in a prominent decrease in growth and a 50% reduction in metabolic activity, respectively. PG was defined as a resurgence of growth (>50% of that in the drug-free growth control well) at drug concentrations above the MIC. With the exception of C. tropicalis, all isolates displayed PG more frequently when they were grown as biofilms than when they grown as planktonic cells. PG was undetectable among C. metapsilosis isolates in planktonic cell MIC tests but was present in 100% of the isolates in biofilm MIC tests. The drug concentration and the number of drug dilutions supporting PG were higher for biofilms than for planktonic cells. Microscopic changes in cell morphology were observed among both planktonic and biofilm cells with PG. Specifically, the accumulation of enlarged, globose cells was associated with PG, and we hypothesize that CAS-induced changes in the cell wall composition may be the explanation. Descriptors Antifungal Agents/pharmacology, Biofilms/drug effects, Candida/drug effects/growth & development/physiology, Candidiasis/microbiology, Echinocandins/pharmacology, Microbial Sensitivity Tests, Risk, Tetrazolium Salts Links Book Title Database Publisher Data Source Authors Melo,A. S., Colombo,A. L., Arthington-Skaggs,B. A. Original/Translated Title URL Date of Electronic 20070625 PMCID PMC2043224 Editors
Snuffing out cigarette sales and the smoking deaths epidemic	2007	SmokeLess New Zealand Trust, Lyttelton, Christchurch. laugesen@healthnz.co.nz	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The New Zealand medical journal Periodical, Abbrev. N.Z.Med.J. Pub Date Free Form 15-Jun Volume 120 Issue 1256 Start Page U2587 Other Pages Notes JID: 0401067; CIN: N Z Med J. 2007;120(1256):U2585. PMID: 17589553; RF: 24; epublish Place of Publication New Zealand ISSN/ISBN 1175-8716; 0028-8446 Accession Number PMID: 17589555 Language eng SubFile Journal Article; Review; IM DOI Output Language Unknown(0) PMID 17589555 Abstract Smokers need new products and policies to escape smoking's risks. And the next generation needs policies that will better protect them from becoming smokers. Low-nitrosamine tobacco snuff (hereafter termed 'snuff') is 20 times less dangerous than cigarette smoking. Its sale as nasal snuff raises the question as to how long cigarettes, including cigars and pipe tobacco, should continue to be sold and allowed to hasten the deaths of 4000 New Zealanders annually. Oral snuff has helped to reduce smoking to unusually low levels in Swedish men, is much less dangerous than smoking, and does not cause lung or mouth cancer. Moreover, smokeless tobacco (which includes snuff) could reduce smoking-caused health inequity for Maori. Snuff can improve population health, and more so if more smokers switch to it. Continued bans on snuff are now regarded by some experts as unsound public policy. Added to the mountain of evidence against cigarettes, sufficient evidence now exists for Government to use snuff to create safer tobacco choices for smokers, end cigarette sales altogether, and thus end the cigarette smoking deaths epidemic--in which 200,000 New Zealanders have died so far. The New Zealand Government can: Fund media campaigns to inform smokers of their new choices, and to urge them to quit smoking. (The 2007 Budget commits an extra $11 million per year for 4 years, an excellent start.) Regulate for warnings on snuff cans stating that snuff is "addictive but much safer than smoking", and regulate imports to only permit reduced-risk low-nitrosamine products. Tax each class of tobacco products proportionate to the respective risks of each. (Tax cigarettes at 20 times the snuff rate, instead of at the same rate.) Legislate, to expand the Smoke-free Environments Act's aims to include ending the sale of cigarettes and ending smoking deaths--i.e: Allow oral snuff to compete with cigarettes for market share (and for the smoker's nicotine receptors). Reduce addiction to smoking, by decreasing the nicotine content of cigarettes by 5% every 6 months. (Below 20% of current levels, most smokers will quit or switch to snuff.), Allot cigarette supply quotas to manufacturers and importers, decreasing by 5% every 6 months, on the grounds that cigarette smoke is irremediably toxic. The summed effects of these changes could end cigarette sales within 10 years, and prevent 90% of cigarette deaths within 22 years thereafter. Descriptors Cause of Death, Female, Harm Reduction, Humans, Incidence, Male, New Zealand/epidemiology, Policy Making, Risk Factors, Smoking/mortality/prevention & control, Survival Analysis, Tobacco Industry/legislation & jurisprudence, Tobacco Use Cessation/methods, Tobacco, Smokeless/adverse effects Links Book Title Database Publisher Data Source Authors Laugesen,M. Original/Translated Title URL Date of Electronic 20070615 PMCID Editors
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study	2008	Department of Orthopaedic Surgery, Thomas Jefferson University and The Rothman Institute, 925 Chestnut Street, 5(th) Floor, Philadelphia, Pennsylvania, PA 19107, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The spine journal : official journal of the North American Spine Society Periodical, Abbrev. Spine J. Pub Date Free Form May-Jun Volume 8 Issue 3 Start Page 457 Other Pages 465 Notes JID: 101130732; 0 (Bone Morphogenetic Proteins); 0 (osteogenic protein 1 putty, recombinant human); 2007/01/16 [received]; 2007/03/12 [revised]; 2007/03/19 [accepted]; 2007/05/25 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1529-9430; 1529-9430 Accession Number PMID: 17588821 Language eng SubFile Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM DOI S1529-9430(07)00128-3 [pii] Output Language Unknown(0) PMID 17588821 Abstract BACKGROUND CONTEXT: Although autogenous bone is still considered to be the gold standard graft material for promoting spinal fusion, other bone graft substitutes have been developed in an attempt to improve arthrodesis rates and avoid the complications associated with the procurement of autograft. The bone morphogenetic proteins (BMPs) represent a family of osteoinductive growth factors that are known to stimulate the osteoblastic differentiation of stem cells. Osteogenic protein-1 (OP-1) Putty is a commercially available BMP preparation that is already approved for use in humans. Previous clinical studies involving patients with degenerative spondylolisthesis have reported that the efficacy and safety of OP-1 Putty is comparable to that of autograft at both 1- and 2-year follow-up. PURPOSE: The purpose of this study was to evaluate the intermediate-term efficacy and safety of OP-1 Putty as an alternative to autogenous bone by comparing the 4-year radiographic, clinical, and safety data of these same patients who underwent decompression and uninstrumented fusion with either OP-1 Putty or iliac crest autograft. STUDY DESIGN/SETTING: A prospective, randomized, controlled, multicenter clinical pilot study. PATIENT SAMPLE: Thirty-six patients undergoing decompressive laminectomy and single-level uninstrumented fusion for degenerative spondylolisthesis and symptomatic spinal stenosis were randomized in a 2:1 fashion to receive either OP-1 Putty (24 patients) or autogenous iliac crest bone graft (12 patients). OUTCOME MEASURES: Patient-reported outcome measures consisting of Oswestry Disability Index and Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) scores were used to evaluate clinical efficacy. Perioperative data including operative time, estimated blood loss, and duration of hospital stay were also recorded for each surgery. Postoperatively, a neurological examination and an assessment of donor-site pain (if applicable) were performed at every follow-up visit. Radiographic fusion success was defined as the presence of continuous bridging bone formation between the transverse processes at the level of the spondylolisthesis with minimal motion evident on dynamic lateral x-ray films. The primary efficacy endpoint was the overall success rate, a composite measure derived from both radiographic and clinical parameters. The safety of OP-1 Putty was confirmed by comparing the nature and frequency of all adverse events and complications that were prospectively observed in either of the groups. METHODS: Thirty-six patients with degenerative spondylolisthesis and symptoms of neurogenic claudication underwent decompressive laminectomy and single-level uninstrumented fusion with either OP-1 Putty or autograft. All patients were evaluated at 6 weeks and 3, 6, 9, 12, and 24 months, after which time they were instructed to return on a yearly basis. Multiple neuroradiologists blinded to the assigned treatment reviewed static and dynamic X-ray films with digital calipers to assess fusion status according to the presence of continuous bridging bone across the transverse processes as well as the amount of residual motion evident at the level of interest. Oswestry Disability Index surveys and SF-36 questionnaires were used to assess clinical outcomes. RESULTS: At the 48-month time point, complete radiographic and clinical data were available for 22 of 36 patients (16 OP-1 Putty and 6 autograft) and 25 of 36 patients (18 OP-1 Putty and 7 autograft), respectively. Radiographic evidence of a solid arthrodesis was present in 11 of 16 OP-1 Putty patients (68.8%) and 3 of 6 autograft patients (50%). Clinically successful outcomes defined as at least a 20% improvement in preoperative Oswestry scores were experienced by 14 of 19 OP-1 Putty patients (73.7%) and 4 of 7 autograft patients (57.1%); these clinical findings were corroborated by similar increases in SF-36 scores. The respective overall success rates of the OP-1 Putty and autograf Descriptors Adult, Aged, Aged, 80 and over, Bone Morphogenetic Proteins/therapeutic use, Female, Follow-Up Studies, Humans, Ilium/transplantation, Lumbosacral Region, Male, Middle Aged, Pilot Projects, Postoperative Complications, Spinal Fusion/methods, Spinal Stenosis/surgery, Spondylolisthesis/surgery, Transplantation, Autologous, Treatment Outcome Links Book Title Database Publisher Data Source Authors Vaccaro,A. R., Whang,P. G., Patel,T., Phillips,F. M., Anderson,D. G., Albert,T. J., Hilibrand,A. S., Brower,R. S., Kurd,M. F., Appannagari,A., Patel,M., Fischgrund,J. S. Original/Translated Title URL Date of Electronic 20070525 PMCID Editors
Determination of benzene, toluene, ethylbenzene, xylenes in water at sub-ng l-1 levels by solid-phase microextraction coupled to cryo-trap gas chromatography-mass spectrometry	2007	Department of Chemistry, National Chung Hsing University, Taichung 40227, Taiwan, ROC. mrlee@drgon.nchu.edu.tw	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Chemosphere Periodical, Abbrev. Chemosphere Pub Date Free Form Nov Volume 69 Issue 9 Start Page 1381 Other Pages 1387 Notes LR: 20131121; JID: 0320657; 0 (Benzene Derivatives); 0 (Water Pollutants, Chemical); 0 (Xylenes); 3FPU23BG52 (Toluene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene); 2006/12/26 [received]; 2007/05/01 [revised]; 2007/05/03 [accepted]; 2007/06/19 [aheado Place of Publication England ISSN/ISBN 0045-6535; 0045-6535 Accession Number PMID: 17582460 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI S0045-6535(07)00615-7 [pii] Output Language Unknown(0) PMID 17582460 Abstract A trace analytical method of benzene, toluene, ethylbenzene and xylenes (BTEX) in water has been developed by using headspace solid-phase microextraction (HS-SPME) coupled to cryo-trap gas chromatography-mass spectrometry (GC-MS). The chromatographic peak shape for BTEX was improved by using cryo-trap equipment. The HS-SPME experimental procedures to extract BTEX from water were optimized with a 75 microm carboxen/polydimethylsiloxane (CAR/PDMS)-coated fiber at a sodium chloride concentration of 267 g l(-1), extraction for 15 min at 25 degrees C and desorption at 290 degrees C for 2 min. Good linearity was verified in a range of 0.0001-50 microg l(-1) for each analyte (r(2)=0.996-0.999). The limits of detection (LODs) of BTEX in water reached at sub-ng l(-1) levels. LODs of benzene, toluene, ethylbenzene, m/p-xylene and o-xylene were 0.04, 0.02, 0.05, 0.01 and 0.02 ng l(-1), respectively. The proposed analytical method was successfully used for the quantification of trace BTEX in ground water. The results indicate that HS-SPME coupled to cryo-trap GC-MS is an effective tool for analysis of BTEX in water samples at the sub-ng l(-1) level. Descriptors Benzene/analysis, Benzene Derivatives/analysis, Environmental Monitoring/methods, Freezing, Gas Chromatography-Mass Spectrometry/methods, Reproducibility of Results, Sensitivity and Specificity, Solid Phase Microextraction, Toluene/analysis, Water Pollutants, Chemical/analysis, Xylenes/analysis Links Book Title Database Publisher Data Source Authors Lee,M. R., Chang,C. M., Dou,J. Original/Translated Title URL Date of Electronic 20070619 PMCID Editors

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