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Polymeric ionic liquid modified stainless steel wire as a novel fiber for solid-phase microextraction	2013	Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of separation science Periodical, Abbrev. J.Sep.Sci. Pub Date Free Form Jan Volume 36 Issue 2 Start Page 369 Other Pages 375 Notes CI: (c) 2012; JID: 101088554; 0 (Ionic Liquids); 0 (Polymers); 0 (Water Pollutants, Chemical); 12597-68-1 (Stainless Steel); 2012/07/07 [received]; 2012/08/28 [revised]; 2012/09/11 [accepted]; ppublish Place of Publication Germany ISSN/ISBN 1615-9314; 1615-9306 Accession Number PMID: 23335459 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1002/jssc.201200644 [doi] Output Language Unknown(0) PMID 23335459 Abstract A polymeric ionic liquid modified stainless steel wire for solid-phase microextraction was reported. Mercaptopropyl-functionalized stainless steel wire that was formed by co-condensation of tetramethoxysilane and 3-mercaptopropyltrimethoxysilane via a sol-gel process, which is followed by in situ surface radical chain-transfer polymerization of 1-vinyl-3-octylimidazolium hexafluorophosphate to result in polymeric ionic liquid modified stainless steel wire. The fiber surface was characterized by field emission scanning electron microscope equipped with energy dispersive X-ray analysis. Coupled with GC, extraction performance of the fiber was tested with phenols and polycyclic aromatic hydrocarbons as model analytes. Effects of extraction and desorption conditions were investigated systematically in our work. RSDs for single-fiber repeatability and fiber-to-fiber reproducibility were less than 7.34 and 16.82%, respectively. The calibration curves were linear in a wide range for all analytes and the detection limits were in the range of 10-60 ng L(-1) . Two real water samples from the Yellow River and local waterworks were applied to test the as-established solid-phase microextraction-GC method with the recoveries of samples spiked at 10 mug L(-1) ranged from 83.35 to 119.24%. The fiber not only exhibited excellent extraction efficiency, but also very good rigidity, stability and durability. Descriptors Links Book Title Database Publisher WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Data Source Authors Xu,L., Jia,J., Feng,J., Liu,J., Jiang,S. Original/Translated Title URL Date of Electronic PMCID Editors
Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence	2009	Department of Digestive Tract Diseases, Medical University of Lodz. anna.mokrowiecka@umed.lodz.pl	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Periodical, Abbrev. Pol.Merkur Lekarski Pub Date Free Form May Volume 26 Issue 155 Start Page 385 Other Pages 389 Notes LR: 20151119; JID: 9705469; 0 (Biomarkers, Tumor); ppublish Place of Publication Poland ISSN/ISBN 1426-9686; 1426-9686 Accession Number PMID: 19606680 Language pol SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 19606680 Abstract The incidence of esophageal adenocarcinoma (ADC) has been increasing rapidly over the past few decades. Gastro-esopageal reflux disease (GERD), Barrett's esophagus (BE) and Barrett-associated dysplasia are a risk factor for esophageal cancer, but endoscopic surveillance have only a limited influence on cancer mortality. There is a great need to find molecular biomarkers predicting increased progression risk in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence to improve risk assessment and stratification of patients to surveillance program. AIM OF THE STUDY: To evaluate the polymorphism and prevalence of loss of heterozygosity (LOH) of APC tumor suppressor gene in mataplasia, dysplasia and adenocarcinoma. MATERIAL AND METHODS: In esophageal mucosal samples of 79 patients with: GERD (n=33), BE (n=27), BE+dysplasia (n=8) and ADC (n=11) we have studied LOH of APC tumor suppressor gene using PCR-restriction fragment length polymorphism (RFLP). A 133 bp fragment, spanning exon 11 of the APC gene was amplified, and Rsal digestion of the PCR product defined the alleles as either homozygous 133 bp (Rsa(-/-)) or 87 and 46 bp (Rsa(+/+)) fragments, and heterozygous (Rsa(+/-)) exhibiting the three fragments. Control peripheral blood cell DNA samples have been collected from 60 normal healthy subjects. RESULTS: Among 79 patients, there were 16 heterozygous (20%) for APC gene. In 16 informative heterozygous LOH was detected in 7 cases: 2/5 with GERD, 3/7--with BE, 1/2--with BE+dysplasia and 1/2--with ADC. There were no statistical differences between studied groups (NS). Distribution of the three alleles, Rsa(+/-), Rsa(+/+), and Rsa(-/-) was: 38, 47 and 15% in the healthy individuals, 25%, 25% and 50%--in GERD patients, 29%, 41% and 29%--in BE, 36%, 45% and 18% in BE+dysplasia and 25%, 67% and 8% in ADC patients, respectively. The frequency of heterozygous cases in control group was significantly higher than in patients group (p = 0.018), whereas Rsa (-/-) were the most frequent in patients group (p = 0.008). Rsa (-/-) were seen significantly more often in GERD compared to ADC patients (p = 0.005), in opposite to Rsa (+/+), which were significantly more frequent in ADC vs. GERD (p = 0.007). CONCLUSIONS: APC gene inactivation concerns minority of patients with esophageal adenocarcinoma, however, its detection indicates higher risk of progression to ADC. APC alternations appear to be early in GERD-BE-dysplasia-ADC sequence. The specific polymorphism may identify patients with high risk of progression into BE. Descriptors Adenocarcinoma/genetics/pathology, Adult, Aged, Barrett Esophagus/genetics/pathology, Biomarkers, Tumor/analysis, Disease Progression, Esophageal Neoplasms/genetics/pathology, Esophagus/pathology, Female, Gastric Mucosa/pathology, Gastroesophageal Reflux/genetics/pathology, Genes, APC, Heterozygote, Humans, Hyperplasia, Loss of Heterozygosity/genetics, Male, Metaplasia, Middle Aged, Polymorphism, Genetic, Precancerous Conditions/genetics Links Book Title Database Publisher Data Source Authors Mokrowiecka,A., Wierzchniewska-Lawska,A., Smolarz,B., Romanowicz-Makowska,H., Malecka-Panas,E. Original/Translated Title Polimorfizm/utrata heterozygotycznosci genu APC w sekwencji GERD-przelyk barretta-dysplazja-rak gruczolowy przelyku URL Date of Electronic PMCID Editors
Polyneuropathy due to lead poisoning from water pipes	1968	Dagnino, N.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Sistema nervoso Periodical, Abbrev. Sist.Nerv. Pub Date Free Form / Volume 20 Issue 6 Start Page 417 Other Pages 420 Notes Place of Publication ISSN/ISBN 0049-0636 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract Descriptors water, adult, article, case report, electromyography, finger, human, lead poisoning, leg, male, motor dysfunction, paresthesia, pathology, peripheral neuropathy, radial nerve Links Book Title Polineuropatia da saturnismo idrico. Database MEDLINE Publisher Data Source Embase Authors Dagnino,N., Badino,R. Original/Translated Title URL Date of Electronic PMCID Editors
Polyphasic approach to bacterial dynamics during the ripening of Spanish farmhouse cheese, using culture-dependent and -independent methods	2008	Departamento de Microbiologia, Facultad de Ciencias, Fuentenueva s/n, 18071 Granada, Spain. mmartine@ugr.es	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Applied and Environmental Microbiology Periodical, Abbrev. Appl.Environ.Microbiol. Pub Date Free Form Sep Volume 74 Issue 18 Start Page 5662 Other Pages 5673 Notes LR: 20140903; JID: 7605801; 0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S); OID: NLM: PMC2547036; 2008/07/25 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1098-5336; 0099-2240 Accession Number PMID: 18658288 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1128/AEM.00418-08 [doi] Output Language Unknown(0) PMID 18658288 Abstract We studied the dynamics of the microbial population during ripening of Cueva de la Magaha cheese using a combination of classical and molecular techniques. Samples taken during ripening of this Spanish goat's milk cheese in which Lactococcus lactis and Streptococcus thermophilus were used as starter cultures were analyzed. All bacterial isolates were clustered by using randomly amplified polymorphic DNA (RAPD) and identified by 16S rRNA gene sequencing, species-specific PCR, and multiplex PCR. Our results indicate that the majority of the 225 strains isolated and enumerated on solid media during the ripening period were nonstarter lactic acid bacteria, and Lactobacillus paracasei was the most abundant species. Other Lactobacillus species, such as Lactobacillus plantarum and Lactobacillus parabuchneri, were also detected at the beginning and end of ripening, respectively. Non-lactic-acid bacteria, mainly Kocuria and Staphylococcus strains, were also detected at the end of the ripening period. Microbial community dynamics determined by temporal temperature gradient gel electrophoresis provided a more precise estimate of the distribution of bacteria and enabled us to detect Lactobacillus curvatus and the starter bacteria S. thermophilus and L. lactis, which were not isolated. Surprisingly, the bacterium most frequently found using culture-dependent analysis, L. paracasei, was scarcely detected by this molecular approach. Finally, we studied the composition of the lactobacilli and their evolution by using length heterogeneity PCR. Descriptors Animals, Biodiversity, Cheese/microbiology, Colony Count, Microbial, DNA Fingerprinting, DNA, Bacterial/genetics, Ecosystem, Electrophoresis, Gel, Pulsed-Field, Food Microbiology, Genotype, Goats, Lactococcus/classification/genetics/growth & development, Milk/microbiology, Polymerase Chain Reaction, RNA, Ribosomal, 16S/genetics, Random Amplified Polymorphic DNA Technique, Species Specificity, Streptococcus thermophilus/growth & development, Time Factors Links Book Title Database Publisher Data Source Authors Martin-Platero,A. M., Valdivia,E., Maqueda,M., Martin-Sanchez,I., Martinez-Bueno,M. Original/Translated Title URL Date of Electronic 20080725 PMCID PMC2547036 Editors
Polyphasic study of the spatial distribution of microorganisms in Mexican pozol, a fermented maize dough, demonstrates the need for cultivation-independent methods to investigate traditional fermentations	1999	Laboratoire de Biotechnologie Microbienne Tropicale, Institut de Recherche pour le Developpement, F-34032 Montpellier cedex 1, France. Frederic.Ampe@mpl.ird.fr	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Applied and Environmental Microbiology Periodical, Abbrev. Appl.Environ.Microbiol. Pub Date Free Form Dec Volume 65 Issue 12 Start Page 5464 Other Pages 5473 Notes LR: 20140615; GENBANK/AF138777; GENBANK/AF138778; GENBANK/AF138779; GENBANK/AF138780; GENBANK/AF138781; GENBANK/AF138782; GENBANK/AF138783; GENBANK/AF138784; GENBANK/AF138785; GENBANK/AF138786; GENBANK/AF138787; GENBANK/AF138788; JID: 7605801; 0 (DNA, Bac Place of Publication UNITED STATES ISSN/ISBN 0099-2240; 0099-2240 Accession Number PMID: 10584005 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI Output Language Unknown(0) PMID 10584005 Abstract The distribution of microorganisms in pozol balls, a fermented maize dough, was investigated by a polyphasic approach in which we used both culture-dependent and culture-independent methods, including microbial enumeration, fermentation product analysis, quantification of microbial taxa with 16S rRNA-targeted oligonucleotide probes, determination of microbial fingerprints by denaturing gradient gel electrophoresis (DGGE), and 16S ribosomal DNA gene sequencing. Our results demonstrate that DGGE fingerprinting and rRNA quantification should allow workers to precisely and rapidly characterize the microbial assemblage in a spontaneous lactic acid fermented food. Lactic acid bacteria (LAB) accounted for 90 to 97% of the total active microflora; no streptococci were isolated, although members of the genus Streptococcus accounted for 25 to 50% of the microflora. Lactobacillus plantarum and Lactobacillus fermentum, together with members of the genera Leuconostoc and Weissella, were the other dominant organisms. The overall activity was more important at the periphery of a ball, where eucaryotes, enterobacteria, and bacterial exopolysacharide producers developed. Our results also showed that the metabolism of heterofermentative LAB was influenced in situ by the distribution of the LAB in the pozol ball, whereas homolactic fermentation was controlled primarily by sugar limitation. We propose that starch is first degraded by amylases from LAB and that the resulting sugars, together with the lactate produced, allow a secondary flora to develop in the presence of oxygen. Our results strongly suggest that cultivation-independent methods should be used to study traditional fermented foods. Descriptors Agriculture/methods, Bacteria/classification/genetics/isolation & purification, DNA Fingerprinting, DNA, Bacterial/genetics, DNA, Ribosomal/genetics, Fermentation, Mexico, Polymerase Chain Reaction, RNA, Bacterial/genetics, RNA, Ribosomal, 16S/genetics, Zea mays/microbiology Links Book Title Database Publisher Data Source Authors Ampe,F., ben Omar,N., Moizan,C., Wacher,C., Guyot,J. P. Original/Translated Title URL Date of Electronic PMCID PMC91745 Editors
Polythiophene/hexagonally ordered silica nanocomposite coating as a solid-phase microextraction fiber for the determination of polycyclic aromatic hydrocarbons in water	2014	Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of separation science Periodical, Abbrev. J.Sep.Sci. Pub Date Free Form Jan Volume 37 Issue 2-Jan Start Page 120 Other Pages 126 Notes CI: (c) 2013; JID: 101088554; 0 (Polycyclic Hydrocarbons, Aromatic); 0 (Water Pollutants, Chemical); 7631-86-9 (Silicon Dioxide); OTO: NOTNLM; 2013/08/23 [received]; 2013/11/02 [revised]; 2013/11/03 [accepted]; 2013/12/12 [aheadofprint]; ppublish Place of Publication Germany ISSN/ISBN 1615-9314; 1615-9306 Accession Number PMID: 24243551 Language eng SubFile Evaluation Studies; Journal Article; IM DOI 10.1002/jssc.201300937 [doi] Output Language Unknown(0) PMID 24243551 Abstract A highly porous fiber coated with polythiophene/hexagonally ordered silica nanocomposite was prepared for solid-phase microextraction (SPME). The prepared nanomaterial was immobilized onto a stainless-steel wire for the fabrication of the SPME fiber. Polythiophene/hexagonally ordered silica nanocomposite fibers were used for the extraction of some polycyclic aromatic hydrocarbons from water samples. The extracted analytes were transferred to the injection port of a gas chromatograph using a laboratory-designed SPME device. The results obtained prove the ability of the polythiophene/hexagonally ordered silica material as a new fiber for the sampling of organic compounds from water samples. This behavior is due most probably to the increased surface area of the polythiophene/hexagonally ordered silica nanocomposite. A one-at-a-time optimization strategy was applied for optimizing the important extraction parameters such as extraction temperature, extraction time, ionic strength, stirring rate, and desorption temperature and time. Under the optimum conditions, the LOD of the proposed method is 0.1-3 pg/mL for analysis of polycyclic aromatic hydrocarbons from aqueous samples, and the calibration graphs were linear in a concentration range of 0.001-20 ng/mL (R(2) > 0.990) for most of the polycyclic aromatic hydrocarbons. The single fiber repeatability and fiber-to-fiber reproducibility were less than 8.6 and 19.1% (n = 5), respectively. Descriptors Links Book Title Database Publisher WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Data Source Authors Abolghasemi,M.M., Yousefi,V. Original/Translated Title URL Date of Electronic 20131212 PMCID Editors
Polytobacco Use Among College Students	2016		Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine Tob Res Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Volume 18 Issue 2 Start Page 163 Other Pages 9 Notes ID: 25770131 Place of Publication ISSN/ISBN Accession Number Language en SubFile DOI Output Language Unknown(0) PMID Abstract INTRODUCTION: Use of more than one tobacco product among college students is increasing in popularity, leading to nicotine addiction and additional health risks. The study (1) examined polytobacco use patterns among college students who had ever used tobacco; and (2) assessed the sociodemographic and personal factors associated with current polytobacco use, compared to current single product use and former tobacco use among college students. METHODS: Of 10,000 randomly selected college students from a large public university in the Southeast, a sample of 1593 students age 18 or older completed an online survey assessing tobacco use and attitudes. Ever tobacco users were included in this study (n = 662, or 41.6% of survey completers). RESULTS: About 15% of ever users reported current polytobacco use, and more than 70% of polytobacco users smoked cigars, little cigars, or clove cigarettes in combination with one or more products. Cigarettes were the most commonly-used product among single users, followed by hookah. Males, underclassmen, and students with greater acceptance of cigarette use were more likely to be polytobacco users. Race/ethnicity was marginally related to polyuse status, with white/non-Hispanics 28% less likely to be polytobacco users versus single product users. CONCLUSIONS: Polytobacco users were more likely than single users to consume emerging tobacco products, (ie, hookah and electronic cigarettes). Males, underclassmen, and racial/ethnic minorities were more at risk for polytobacco use. As young people are particularly prone to nicotine addiction, there is a need to further investigate polytobacco use among college students. Descriptors Links http://dx.doi.org/10.1093/ntr/ntv056 Book Title Database MEDLINE; http://www.globalhealthlibrary.net/ Publisher Data Source Authors Butler,Karen M., Ickes,Melinda J., Rayens,Mary Kay, Wiggins,Amanda T., Hahn,Ellen J. Original/Translated Title URL Date of Electronic PMCID Editors
Polytobacco Use of Cigarettes, Cigars, Chewing Tobacco, and Snuff Among US Adults	2016	Institute for Health & Aging, School of Nursing, University of California, San Francisco, CA; hai-yen.sung@ucsf.edu.; Institute for Health & Aging, School of Nursing, University of California, San Francisco, CA;; Institute for Health & Aging, School of Nu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form May Volume 18 Issue 5 Start Page 817 Other Pages 826 Notes LR: 20160410; CI: (c) The Author 2015; GR: 1P50CA180890/CA/NCI NIH HHS/United States; GR: P50 CA180890/CA/NCI NIH HHS/United States; JID: 9815751; 2015/03/03 [received]; 2015/06/26 [accepted]; 2015/06/30 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 26136525 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; IM DOI 10.1093/ntr/ntv147 [doi] Output Language Unknown(0) PMID 26136525 Abstract INTRODUCTION: Tobacco use prevalence has been commonly estimated on a product by product basis and the extent of polytobacco use among current users of each tobacco product is not well understood. This study aimed to examine the prevalence, trends, and correlates of polytobacco use among current users of cigarettes, cigars, chewing tobacco, and snuff in US adults aged >/=18. METHODS: We used pooled data from the 1998, 2000, 2005, and 2010 Cancer Control Supplements of the National Health Interview Survey (N = 123 399 adults). Multivariate logistic regression models were estimated to determine significant factors associated with polytobacco use. RESULTS: In 2010, the prevalence of polytobacco use was 8.6% among current cigarette smokers, 50.3% among current cigar users, 54.8% among current chewing tobacco users, and 42.5% among current snuff users. After controlling for other covariates, gender and race/ethnicity did not show consistent associations with poly-use across these four groups of current tobacco users; however, a positive association of young adulthood, less than high school education, and binge drinking with poly-use was consistently found among all these groups. CONCLUSIONS: Polytobacco use is extremely popular among current users of non-cigarette tobacco products. Polytobacco use patterns differ across sociodemographic subpopulations, and the gender and racial/ethnic profiles in poly-users vary across different groups of current tobacco users. Tobacco control strategies need to consider the interrelationships in the use of different tobacco products and the diverse profiles of poly-users in order to develop tailored tobacco prevention and intervention policies to further reduce the burden of tobacco use. Descriptors Links Book Title Database Publisher . Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco Data Source Authors Sung,H.Y., Wang,Y., Yao,T., Lightwood,J., Max,W. Original/Translated Title URL Date of Electronic 20150630 PMCID Editors
Polytobacco, marijuana, and alcohol use patterns in college students: A latent class analysis	2016	Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, United States.; Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emor	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Aug Volume 59 Issue Start Page 58 Other Pages 64 Notes LR: 20160527; CI: Copyright (c) 2016; GR: K05 AA021143/AA/NIAAA NIH HHS/United States; GR: R01 CA179422/CA/NCI NIH HHS/United States; JID: 7603486; NIHMS777025; OID: NLM: NIHMS777025 [Available on 08/01/17]; OID: NLM: PMC4846569 [Available on 08/01/17]; O Place of Publication England ISSN/ISBN 1873-6327; 0306-4603 Accession Number PMID: 27074202 Language eng SubFile Journal Article; IM DOI 10.1016/j.addbeh.2016.03.034 [doi] Output Language Unknown(0) PMID 27074202 Abstract Limited research has examined polysubstance use profiles among young adults focusing on the various tobacco products currently available. We examined use patterns of various tobacco products, marijuana, and alcohol using data from the baseline survey of a multiwave longitudinal study of 3418 students aged 18-25 recruited from seven U.S. college campuses. We assessed sociodemographics, individual-level factors (depression; perceptions of harm and addictiveness,), and sociocontextual factors (parental/friend use). We conducted a latent class analysis and multivariable logistic regression to examine correlates of class membership (Abstainers were referent group). Results indicated five classes: Abstainers (26.1% per past 4-month use), Alcohol only users (38.9%), Heavy polytobacco users (7.3%), Light polytobacco users (17.3%), and little cigar and cigarillo (LCC)/hookah/marijuana co-users (10.4%). The most stable was LCC/hookah/marijuana co-users (77.3% classified as such in past 30-day and 4-month timeframes), followed by Heavy polytobacco users (53.2% classified consistently). Relative to Abstainers, Heavy polytobacco users were less likely to be Black and have no friends using alcohol and perceived harm of tobacco and marijuana use lower. Light polytobacco users were older, more likely to have parents using tobacco, and less likely to have friends using tobacco. LCC/hookah/marijuana co-users were older and more likely to have parents using tobacco. Alcohol only users perceived tobacco and marijuana use to be less socially acceptable, were more likely to have parents using alcohol and friends using marijuana, but less likely to have friends using tobacco. These findings may inform substance use prevention and recovery programs by better characterizing polysubstance use patterns. Descriptors Links Book Title Database Publisher Elsevier Ltd Data Source Authors Haardorfer,R., Berg,C.J., Lewis,M., Payne,J., Pillai,D., McDonald,B., Windle,M. Original/Translated Title URL Date of Electronic 20160402 PMCID PMC4846569 Editors
Polyvascular extracoronary atherosclerotic disease in patients with coronary artery disease	2009	Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Collegium Medicum, The John Paul II Hospital, Krakow, Poland. tadeuszprzewlocki@op.pl	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Kardiologia polska Periodical, Abbrev. Kardiol.Pol. Pub Date Free Form Aug Volume 67 Issue 8A Start Page 978 Other Pages 984 Notes LR: 20140730; JID: 0376352; ppublish Place of Publication Poland ISSN/ISBN 0022-9032; 0022-9032 Accession Number PMID: 19784902 Language eng SubFile Journal Article; IM DOI Output Language Unknown(0) PMID 19784902 Abstract BACKGROUND: Cardiovascular diseases are the number one killer in the developed countries, accounting for approximately half of all deaths, with the leading causes being myocardial infarction and ischaemic stroke. In line with the ageing population, the prevalence of coronary artery disease (CAD), lower extremity peripheral arterial disease (PAD), supra-aortic arterial disease (SAD) and renal stenosis (RAS) is increasing. Polyvascular atherosclerosis (PVA) coexisting in several territories has an adverse effect on cardiovascular morbidity and mortality. AIM: To determine prevalence, coexistence and predictors of significant PAD, SAD and RAS in patients with suspected CAD. METHODS: Based on angiography, the frequency of coexisting CAD, SAD, PAD and RAS (stenosis > or =50%) was determined in 687 (487 male) consecutive patients, aged 63.5 +/- 9.1 years, referred for coronary angiography. RESULTS: Significant CAD was found in 545 (79.3%) patients (1-vessel in 164; 2-vessel in 157; 3-vessel in 224). SAD, RAS and PAD were found in 136 (19.8%), 55 (8%), and 103 (15%) patients, respectively. Of the 545 patients with confirmed CAD, 346 (63.5%) had stenoses limited to coronary arteries. 2-, 3- and 4-level PVA was found in 130 (23.8%), 61 (11.2%) and 8 (1.5%) patients, respectively. Of the 142 patients without CAD, 127 (89.4%) had no significant stenoses elsewhere, 12 (8.5%) had 1 extracoronary territory and 3 (2.1%) had 2-territory involvement. Backward stepwise binary logistic regression analysis showed the following independent predictors of at least 2-level PVA: 2- and 3-vessel CAD (p or = 1.3 ml/dl (p or = 1.3 ml/dl (p 1.3 mg/dl; and 1.9-fold, 2.4-fold and 2-fold in patients with hyperlipidaemia, smokers and women, respectively. CONCLUSIONS: Significant atherosclerosis in extracoronary arterial territories is present in 36% of patients with documented CAD. With advancing PVA, accumulation of atherosclerosis risk factors, previous atherothrombotic events and more severe CAD is observed. Descriptors Adult, Aged, Aortic Stenosis, Supravalvular/diagnosis/epidemiology, Comorbidity, Coronary Angiography, Coronary Artery Disease/diagnosis/epidemiology, Female, Humans, Hypertension, Renal/epidemiology, Intermittent Claudication/epidemiology, Logistic Models, Male, Middle Aged, Peripheral Vascular Diseases/diagnosis/epidemiology, Poland/epidemiology, Prevalence, Renal Artery Obstruction/epidemiology, Risk Assessment, Severity of Illness Index, Smoking/epidemiology Links Book Title Database Publisher Data Source Authors Przewlocki,T., Kablak-Ziembicka,A., Kozanecki,A., Rzeznik,D., Pieniazek,P., Musialek,P., Piskorz,A., Sokolowski,A., Roslawiecka,A., Tracz,W. Original/Translated Title URL Date of Electronic PMCID Editors

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