WTS database

Title	Pub Year	Author Sort ascending	SearchLink
Lung function and exposure to workplace second-hand smoke during exemptions from smoking ban legislation: an exposure-response relationship based on indoor PM2.5 and urinary cotinine levels	2011	The University of Hong Kong, 5/F William MW Mong Block, 21 Sassoon Road, Pokfulam, Hong Kong, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Thorax Periodical, Abbrev. Thorax Pub Date Free Form Jul Volume 66 Issue 7 Start Page 615 Other Pages 623 Notes LR: 20131121; JID: 0417353; 0 (Air Pollutants, Occupational); 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); K5161X06LL (Cotinine); 2011/05/06 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3296; 0040-6376 Accession Number PMID: 21551212 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1136/thx.2011.160291 [doi] Output Language Unknown(0) PMID 21551212 Abstract BACKGROUND: The effects of workplace second-hand smoke (SHS) on lung function remain uncertain because of a lack of objective measures for SHS exposures. OBJECTIVE: To determine whether an exposure-response association exists between lung function and two different markers of SHS based on indoor fine particulate (PM(2.5)) and urinary cotinine levels in non-smoking catering workers. DESIGN: A cross-sectional study during a 1.5-year exemption of licensed catering premises from smoke-free legislation. Participants 186 non-smoking catering workers aged 18-65 years in Hong Kong were recruited. A declared non-smoking status was accepted in workers with exhaled breath carbon monoxide levels 175 mug/m(3)) with FEV(1) -0.072 (95% CI -0.123 to -0.021), -0.078 (95% CI -0.132 to -0.024), -0.101 (95% CI -0.187 to -0.014); FEF(25-75) -0.368 (95% CI -0.660 to -0.077), -0.489 (95% CI -0.799 to -0.179), -0.597 (95% CI -0.943 to -0.251); and FEV(1)/FVC (%) -2.9 (95% CI -4.8 to -1.0), -3.2 (95% CI -5.1 to -1.4) and -4.4 (95% CI -7.4 to -1.3), respectively. Urinary cotinine was associated positively with indoor PM(2.5) but negatively with lung function. Consistently lower values for lung function per unit increase of indoor PM(2.5) were found. CONCLUSION: Lung function is inversely associated with workplace SHS. Workplace exemptions and delays in implementing smoke-free policies and current moves to relax legislation are a major threat to the health of workers. Descriptors Links Book Title Database Publisher Data Source Authors Lai,H.K., Hedley,A.J., Repace,J., So,C., Lu,Q.Y., McGhee,S.M., Fielding,R., Wong,C.M. Original/Translated Title URL Date of Electronic 20110506 PMCID Editors
Particulate matter and carbon monoxide multiple regression models using environmental characteristics in a high diesel-use area of Baguio City, Philippines	2007	The University of Georgia (UGA), College of Public Health, Department of Environmental Health Science, Athens, Georgia, GA 30602-2102, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Science of the total environment Periodical, Abbrev. Sci.Total Environ. Pub Date Free Form 1-Aug Volume 381 Issue 3-Jan Start Page 47 Other Pages 58 Notes LR: 20131121; JID: 0330500; 0 (Air Pollutants); 0 (Gasoline); 0 (Particulate Matter); 0 (Vehicle Emissions); 7U1EE4V452 (Carbon Monoxide); 2006/09/12 [received]; 2007/02/20 [revised]; 2007/03/02 [accepted]; 2007/05/03 [aheadofprint]; ppublish Place of Publication Netherlands ISSN/ISBN 0048-9697; 0048-9697 Accession Number PMID: 17481696 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI S0048-9697(07)00303-8 [pii] Output Language Unknown(0) PMID 17481696 Abstract In Baguio City, Philippines, a mountainous city of 252,386 people where 61% of motor vehicles use diesel fuel, ambient particulate matter 0.05) from either rush hour PM(2.5) concentration (morning=98+/-7 microg/m3; afternoon=107+/-5 microg/m3) due to nocturnal inversions in spite of a 100% increase in automotive density during rush hours. Early morning street-level CO (3.0+/-1.7 ppm) differed from morning rush hour (4.1+/-2.3 ppm) (p=0.039) and afternoon rush hour (4.5+/-2.2 ppm) (p=0.007). Additionally, PM(2.5), PM(10), CO, nitrogen dioxide (NO2) and select volatile organic compounds were continuously measured at a downtown, third-story monitoring station along a busy roadway for 11 days. Twenty-four-hour average ambient concentrations were: PM(2.5)=72.9+/-21 microg/m3; CO=2.61+/-0.6 ppm; NO2=27.7+/-1.6 ppb; benzene=8.4+/-1.4 microg/m3; ethylbenzene=4.6+/-2.0 microg/m3; p-xylene=4.4+/-1.9 microg/m3; m-xylene=10.2+/-4.4 microg/m3; o-xylene=7.5+/-3.2 microg/m3. The multiple regression models suggest that traffic and wind in Baguio City, Philippines significantly affect street-level pollution concentrations. Ambient PM(2.5) levels measured are above USEPA daily (65 microg/m3) and Filipino/USEPA annual standards (15 microg/m3) with concentrations of a magnitude rarely seen in most countries except in areas where local topography plays a significant role in air pollution entrapment. The elevated pollution concentrations present and the diesel-rich nature of motor vehicle emissions are important pertaining to human exposure and health information and as such warrant public health concern. Descriptors Air Pollutants/analysis, Carbon Monoxide/analysis, Environmental Monitoring, Gasoline, Linear Models, Particle Size, Particulate Matter/analysis, Philippines, Vehicle Emissions/analysis Links Book Title Database Publisher Data Source Authors Cassidy,B. E., Alabanza-Akers,M. A., Akers,T. A., Hall,D. B., Ryan,P. B., Bayer,C. W., Naeher,L. P. Original/Translated Title URL Date of Electronic 20070503 PMCID Editors
Effect of in-office bleaching agents on the color changes of stained ceromers and direct composite resins	2014	The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University , Wuhan , PR China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta Odontologica Scandinavica Periodical, Abbrev. Acta Odontol.Scand. Pub Date Free Form Nov Volume 72 Issue 8 Start Page 1032 Other Pages 1038 Notes JID: 0370344; 0 (Coffee); 0 (Composite Resins); 0 (Dental Materials); 0 (Drug Combinations); 0 (Gradia); 0 (Peroxides); 0 (Polyvinyls); 0 (Silicates); 0 (Tea); 0 (Tooth Bleaching Agents); 0 (ceramage); 0 (ceromer); 0 (tooth-bleaching agent, Opalescence); Place of Publication England ISSN/ISBN 1502-3850; 0001-6357 Accession Number PMID: 25196263 Language eng SubFile Comparative Study; Journal Article; D; IM DOI 10.3109/00016357.2014.946962 [doi] Output Language Unknown(0) PMID 25196263 Abstract PURPOSE: To evaluate the effect of two in-office bleaching agents on the color changes of two ceromers (Ceramage and Adoro SR) and one direct composite resin (Gradia Direct Anterior) after staining by tea and coffee. MATERIALS AND METHODS: Twenty-four disk-shaped specimens were fabricated for each resin material and randomly divided into three groups (n = 8). The specimens were immersed in tea, coffee or deionized water, respectively, for 7 days. Each group was then equally divided into two sub-groups (n = 4), which were subjected to two in-office bleaching agents (BEYOND and Opalescence Boost), respectively. The color of the specimens was measured by a spectrophotometer at baseline, after staining and after bleaching. The color differences (DeltaE values) between baseline and after treatments were calculated. RESULTS: Statistical analysis indicated that the staining solution had significant influence on the color change of resin composites tested (p 2.0). There was no statistically significant difference between BEYOND and Opalescence Boost in stains removal from discolored resins (p = 0.550). The color changes in DeltaE value between baseline and after bleaching were less than 2.0 for all resin composite groups. CONCLUSIONS: Tea solution produces severe discoloration of three resin composites tested. The two in-office bleaching agents can effectively remove the stains from two ceromers and one direct composite resin tested in this study. Descriptors Links Book Title Database Publisher Data Source Authors Xing,W., Jiang,T., Liang,S., Sa,Y., Wang,Z., Chen,X., Wang,Y. Original/Translated Title URL Date of Electronic 20140908 PMCID Editors
The association between obesity and GERD: a review of the epidemiological evidence	2008	The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA. hasheme@bcm.tmc.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Digestive diseases and sciences Periodical, Abbrev. Dig.Dis.Sci. Pub Date Free Form Sep Volume 53 Issue 9 Start Page 2307 Other Pages 2312 Notes LR: 20140912; GR: R01 CA116845/CA/NCI NIH HHS/United States; GR: R01 CA116845-03/CA/NCI NIH HHS/United States; JID: 7902782; RF: 50; NIHMS176037; OID: NLM: NIHMS176037; OID: NLM: PMC2827866; 2008/05/23 [received]; 2008/06/18 [accepted]; 2008/07/24 [aheado Place of Publication United States ISSN/ISBN 0163-2116; 0163-2116 Accession Number PMID: 18651221 Language eng SubFile Journal Article; Meta-Analysis; Review; AIM; IM DOI 10.1007/s10620-008-0413-9 [doi] Output Language Unknown(0) PMID 18651221 Abstract The current epidemics of obesity and gastroesophageal reflux disease (GERD)-related disorders have generated much interest in studying the association between them. Results of multiple studies indicate that obesity satisfies several criteria for a causal association with GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. An increase in GERD symptoms has been shown to occur in individuals who gain weight but continue to have a body mass index (BMI) in the normal range, contributing to the epidemiological evidence for a possible dose-response relationship between BMI and increasing GERD. Data are less clear on the relationship between Barrett's esophagus (BE) and obesity. However, when considered separately, abdominal obesity seems to explain a considerable part of the association with GERD, including BE. Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications. Descriptors Barrett Esophagus/epidemiology/physiopathology, Body Mass Index, Esophageal Neoplasms/epidemiology/physiopathology, Esophagitis/epidemiology/physiopathology, Gastroesophageal Reflux/epidemiology/physiopathology, Humans, Obesity/epidemiology/physiopathology, Risk Factors Links Book Title Database Publisher Data Source Authors El-Serag,H. Original/Translated Title URL Date of Electronic 20080724 PMCID PMC2827866 Editors
Patterns of combustible tobacco use in U.S. young adults and potential response to graphic cigarette health warning labels	2015	The Schroeder Institute for Tobacco Research and Policy Studies, Legacy, Washington, DC, USA; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: avillanti@legacyforhealth.or	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Mar Volume 42 Issue Start Page 119 Other Pages 125 Notes CI: Copyright (c) 2014; GR: HHSN271201100027C/PHS HHS/United States; JID: 7603486; OTO: NOTNLM; 2014/05/16 [received]; 2014/10/03 [revised]; 2014/11/14 [accepted]; 2014/11/21 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1873-6327; 0306-4603 Accession Number PMID: 25437268 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; IM DOI 10.1016/j.addbeh.2014.11.011 [doi] Output Language Unknown(0) PMID 25437268 Abstract In the evolving landscape of tobacco use, it remains unclear how tobacco control efforts should be designed and promoted for maximum impact. The current study links the identification of latent classes of young adult combustible tobacco users with anticipated responses to graphic health warning labels (HWLs). Data were collected in January 2012 using an online address-based panel as part of the Legacy Young Adult Cohort Study, and analyses were conducted in 2013. Latent class analyses identified five groups of tobacco users in a national sample of 4,236 young adults aged 18-34years: (1) little cigar/cigarillo/bidi (LCC) and hookah users (4%); (2) nonusers, open to smoking (3%); (3) daily smokers who self-identify as "smokers" (11%); (4) nondaily, light smokers who self-identify as "social or occasional smokers" (9%); and (5) nonusers closed to smoking (73%). Of the nonusers closed to smoking, 23% may be better characterized as at risk for tobacco initiation. Results indicate differences in the potential effectiveness of HWLs across classes. Compared to the daily "smokers," LCC and hookah users (RRR=2.35) and nonusers closed to smoking (RRR=2.33) were more than twice as likely to report that new graphic HWLs would make them think about not smoking. This study supports the potential of graphic HWLs to prevent young nonusers from using tobacco products. It suggests that the extension of prominent HWLs to other tobacco products, including LCCs and hookah tobacco, may also serve a prevention function. Descriptors Links Book Title Database Publisher Elsevier Ltd Data Source Authors Villanti,A.C., Pearson,J.L., Cantrell,J., Vallone,D.M., Rath,J.M. Original/Translated Title URL Date of Electronic 20141121 PMCID Editors
e-Cigarette awareness, use, and harm perceptions in US adults	2012	The Schroeder Institute for Tobacco Research and Policy Studies at Legacy, Washington, DC 20036, USA. jpearson@legacyforhealth.org	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Public Health Periodical, Abbrev. Am.J.Public Health Pub Date Free Form Sep Volume 102 Issue 9 Start Page 1758 Other Pages 1766 Notes LR: 20160708; GR: F31 DA030016/DA/NIDA NIH HHS/United States; GR: F31 DA030016-01/DA/NIDA NIH HHS/United States; JID: 1254074; 6M3C89ZY6R (Nicotine); NIHMS410314; OID: NLM: NIHMS410314; OID: NLM: PMC3474361; 2012/07/19 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1541-0048; 0090-0036 Accession Number PMID: 22813087 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; AIM; IM DOI 10.2105/AJPH.2011.300526 [doi] Output Language Unknown(0) PMID 22813087 Abstract OBJECTIVES: We estimated e-cigarette (electronic nicotine delivery system) awareness, use, and harm perceptions among US adults. METHODS: We drew data from 2 surveys conducted in 2010: a national online study (n = 2649) and the Legacy Longitudinal Smoker Cohort (n = 3658). We used multivariable models to examine e-cigarette awareness, use, and harm perceptions. RESULTS: In the online survey, 40.2% (95% confidence interval [CI] = 37.3, 43.1) had heard of e-cigarettes, with awareness highest among current smokers. Utilization was higher among current smokers (11.4%; 95% CI = 9.3, 14.0) than in the total population (3.4%; 95% CI = 2.6, 4.2), with 2.0% (95% CI = 1.0, 3.8) of former smokers and 0.8% (95% CI = 0.35, 1.7) of never-smokers ever using e-cigarettes. In both surveys, non-Hispanic Whites, current smokers, young adults, and those with at least a high-school diploma were most likely to perceive e-cigarettes as less harmful than regular cigarettes. CONCLUSIONS: Awareness of e-cigarettes is high, and use among current and former smokers is evident. We recommend product regulation and careful surveillance to monitor public health impact and emerging utilization patterns, and to ascertain why, how, and under what conditions e-cigarettes are being used. Descriptors Links Book Title Database Publisher Data Source Authors Pearson,J.L., Richardson,A., Niaura,R.S., Vallone,D.M., Abrams,D.B. Original/Translated Title URL Date of Electronic 20120719 PMCID PMC3474361 Editors
Perceived discrimination and health-related quality of life among Arabs and Jews in Israel: a population-based survey	2010	The School of Public Health, Faculty of Social Welfare and Health Studies, University of Haifa, Israel. ornaepel@research.haifa.ac.il	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full BMC public health Periodical, Abbrev. BMC Public Health Pub Date Free Form 27-May Volume 10 Issue Start Page 282 Other Pages 2458-10-282 Notes LR: 20151119; JID: 100968562; OID: NLM: PMC2891650; 2009/03/15 [received]; 2010/05/27 [accepted]; 2010/05/27 [aheadofprint]; epublish Place of Publication England ISSN/ISBN 1471-2458; 1471-2458 Accession Number PMID: 20507564 Language eng SubFile Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1186/1471-2458-10-282 [doi] Output Language Unknown(0) PMID 20507564 Abstract BACKGROUND: Studies have shown that perceived discrimination may be associated with impaired health. The aim of this study was to assess the levels of perceived discrimination on the basis of origin and ethnicity and measure the association with health in three population groups in Israel: non-immigrant Jews, immigrants from the former Soviet Union, and Arabs. METHODS: A cross sectional random telephone survey was performed in 2006 covering 1,004 Israelis aged 35-65; of these, 404 were non-immigrant Jews, 200 were immigrants from the former Soviet Union and 400 were Arabs, the final number for regression analysis was 952. Respondents were asked about their perceived experiences with discrimination in seven different areas. Quality of life, both physical and mental were measured by the Short Form 12. RESULTS: Perceived discrimination on the basis of origin was highest among immigrants. About 30% of immigrants and 20% of Arabs reported feeling discriminated against in areas such as education and employment. After adjusting for socioeconomic variables, discrimination was associated with poor physical health among non-immigrant Jews (OR = 0.42, CI = 0.19, 0.91) and immigrants (OR = 0.51, CI = 0.27, 0.94), but not among Arabs. Poor mental health was significantly associated with discrimination only among non-immigrant Jews (OR = 0.42, CI = 0.18, 0.96). CONCLUSIONS: Perceived discrimination seemed high in both minority populations in Israel (Arabs and immigrants) and needs to be addressed as such. However, discrimination was associated with physical health only among Jews (non-immigrants and immigrants), and not among Arabs. These results may be due to measurement artifacts or may be a true phenomenon, further research is needed to ascertain the results. Descriptors Adult, Aged, Arabs/psychology/statistics & numerical data, Cross-Sectional Studies, Emigrants and Immigrants/psychology/statistics & numerical data, Female, Health Status Indicators, Humans, Israel, Jews/psychology/statistics & numerical data, Male, Middle Aged, Odds Ratio, Prejudice, Quality of Life/psychology, Regression Analysis, Surveys and Questionnaires, USSR/ethnology Links Book Title Database Publisher Data Source Authors Epel,O. B., Kaplan,G., Moran,M. Original/Translated Title URL Date of Electronic 20100527 PMCID PMC2891650 Editors
Relationship between right-to-left shunts and cutaneous decompression illness	2001	The Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical science (London, England : 1979) Periodical, Abbrev. Clin.Sci.(Lond) Pub Date Free Form May Volume 100 Issue 5 Start Page 539 Other Pages 542 Notes LR: 20041117; JID: 7905731; ppublish Place of Publication England ISSN/ISBN 0143-5221; 0143-5221 Accession Number PMID: 11294694 Language eng SubFile Journal Article; IM DOI Output Language Unknown(0) PMID 11294694 Abstract The presence of a large right-to-left shunt is associated with neurological decompression illness after non-provocative dives, as a result of paradoxical gas embolism. A small number of observations suggest that cutaneous decompression illness is also associated with a right-to-left shunt, although an embolic aetiology of a diffuse rash is more difficult to explain. We performed a retrospective case--control comparison of the prevalence and sizes of right-to-left shunts determined by contrast echocardiography performed blind to history in 60 divers and one caisson worker with a history of cutaneous decompression illness, and 123 historical control divers. We found that 47 (77.0%) of the 61 cases with cutaneous decompression illness had a shunt, compared with 34 (27.6%) of 123 control divers (P<0.001). The size of the shunts in the divers with cutaneous decompression illness was significantly greater than in the controls. Thus 30 (49.2%) of the 61 cases with cutaneous decompression illness had a large shunt at rest, compared with six (4.9%) of the 123 controls (P<0.001). During closure procedures in 17 divers who had cutaneous decompression illness, the mean diameter of the foramen ovale was 10.9 mm. Cutaneous decompression illness occurred after dives that were provocative or deep in subjects without shunts, but after shallower and non-provocative dives in those with shunts. The latter individuals are at increased risk of neurological decompression illness. We conclude that cutaneous decompression illness has two pathophysiological mechanisms. It is usually associated with a large right-to-left shunt, when the mechanism is likely to be paradoxical gas embolism with peripheral amplification when bubble emboli invade tissues supersaturated with nitrogen. Cutaneous decompression illness can also occur in individuals without a shunt. In these subjects, the mechanism might be bubble emboli passing through an 'overloaded' lung filter or autochthonous bubble formation. Descriptors Case-Control Studies, Decompression Sickness/etiology, Female, Heart Septal Defects, Atrial/complications/surgery/ultrasonography, Humans, Male, Retrospective Studies, Skin Diseases/etiology, Valsalva Maneuver/physiology Links Book Title Database Publisher Data Source Authors Wilmshurst,P. T., Pearson,M. J., Walsh,K. P., Morrison,W. L., Bryson,P. Original/Translated Title URL Date of Electronic PMCID Editors
Modelling the Structure and Dynamics of Biological Pathways	2016	The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, Midlothian, Scotland, United Kingdom.; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full PLoS biology Periodical, Abbrev. PLoS Biol. Pub Date Free Form 10-Aug Volume 14 Issue 8 Start Page e1002530 Other Pages Notes JID: 101183755; 2016/08 [ecollection]; 2016/08/10 [epublish]; epublish Place of Publication United States ISSN/ISBN 1545-7885; 1544-9173 Accession Number PMID: 27509052 Language eng SubFile Journal Article; IM DOI 10.1371/journal.pbio.1002530 [doi] Output Language Unknown(0) PMID 27509052 Abstract There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. Here, we present a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system's dynamics. We present example pathway models that illustrate of the power of approach to depict a diverse range of systems. Descriptors Links Book Title Database Publisher Data Source Authors O'Hara,L., Livigni,A., Theo,T., Boyer,B., Angus,T., Wright,D., Chen,S.H., Raza,S., Barnett,M.W., Digard,P., Smith,L.B., Freeman,T.C. Original/Translated Title URL Date of Electronic 20160810 PMCID Editors
Both environmental tobacco smoke and personal smoking is related to asthma and wheeze in teenagers	2011	The OLIN Study Group, Sunderby Central Hospital of Norrbotten, Lulea, Sweden. linnea.hedman@nll.se	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Thorax Periodical, Abbrev. Thorax Pub Date Free Form Jan Volume 66 Issue 1 Start Page 20 Other Pages 25 Notes JID: 0417353; 0 (Tobacco Smoke Pollution); 2010/11/03 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3296; 0040-6376 Accession Number PMID: 21047869 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1136/thx.2010.143800 [doi] Output Language Unknown(0) PMID 21047869 Abstract BACKGROUND: Environmental tobacco smoke (ETS) has been reported as a significant risk factor for childhood asthma. Among adults, personal smoking is a major cause of respiratory symptoms and diseases. The effects of these exposures on the prevalence of asthma and wheeze among teenagers are less well known. OBJECTIVE: The aim was to study the independent and combined effects of ETS and personal smoking on the prevalence of asthma and wheeze in teenagers. METHODS: A longitudinal study of asthma and allergic diseases in schoolchildren has been in progress in Northern Sweden since 1996. All children aged 7-8 years in three municipalities were invited and 3430 (97%) participants have been followed by annual questionnaires. At the age 16-17 years, 82% of the initial participants took part in the 2005 survey. RESULTS: Prevalence of physician-diagnosed asthma, ever wheeze and current wheeze was significantly higher among those exposed to maternal ETS and among daily smokers. In multivariate analyses, maternal ETS was a significant risk factor for physician-diagnosed asthma and ever wheeze (OR 1.3-1.5) and personal daily smoking for current wheeze (OR 2.0). ORs for asthma and ever wheeze were highest among daily smokers who were also exposed to maternal ETS with ORs of 1.7 and 2.5, respectively. A significant dose-response association between number of cigarettes/day and the prevalence of wheeze was also found. CONCLUSIONS: Both ETS and personal smoking were significantly related to asthma and wheeze in teenagers. Maternal ETS exposure was associated with lifetime symptoms, but daily smoking among the teenagers was more strongly related to current symptoms. Descriptors Links Book Title Database Publisher Data Source Authors Hedman,L., Bjerg,A., Sundberg,S., Forsberg,B., Ronmark,E. Original/Translated Title URL Date of Electronic 20101103 PMCID Editors

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