WTS database

Title	Pub Year	Author Sort descending	SearchLink
AAPI youth tobacco use: a comparative analysis of current cigarette use data from the Florida, Texas, and National Youth Tobacco Surveys	2001	Division of Health Care Management, School of Allied Health Sciences, 223 Ware Rhaney Bldg., Florida A&M University, Tallahassee, FL 32307, USA. kershawj@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Asian American and Pacific Islander journal of health Periodical, Abbrev. Asian Am.Pac.Isl.J.Health. Pub Date Free Form Winter-Spring Volume 9 Issue 1 Start Page 25 Other Pages 33 Notes LR: 20151119; JID: 9417466; ppublish Place of Publication United States ISSN/ISBN 1072-0367; 1072-0367 Accession Number PMID: 11720411 Language eng SubFile Comparative Study; Journal Article; IM DOI Output Language Unknown(0) PMID 11720411 Abstract OBJECTIVES: The objectives of this study were to compile data on Asian American and Pacific Islander (AAPI) youth tobacco use in Florida and conduct comparisons with state and national data. This research will contribute to reducing the gap in information regarding current smoking prevalence among AAPI youth in Florida and provide direct comparisons with another state (Texas) and National Youth Tobacco Survey (NYTS) data on AAPI youth. METHODS: Current cigarette use data from the Florida Youth Tobacco Surveys conducted in 1998, 1999, and 2000 were examined for trends in AAPI and state prevalence rates. AAPI data from Florida's baseline 1998 youth tobacco survey were compared to Texas data after applying a common set of data preparation edits. AAPI data from the NYTS were also compared to Florida's AAPI youth population. FINDINGS: Current cigarette use for AAPI students in Florida was generally below the overall prevalence rates among Florida's public middle or high school students. In 1998, current smoking prevalence among Texas AAPI middle and high school students was 18.7% compared to 19.4% among Florida students. Among high school students, the NYTS found that 21.2% of AAPI students were current cigarette smokers nationally in comparison to 21.7% of AAPI high school youth in Florida. In middle school, the current smoking prevalence among AAPI students was 5.5% in the NYTS as compared to 9.4% in Florida. The NYTS data in particular highlight the magnitude of the increasing trend of cigarette smoking among AAPI youth as they progress through the high school grades. CONCLUSIONS: Of all the racial/ethnic groups in Florida, only AAPIs did not have a significant decline in current cigarette use. While the Florida Tobacco Pilot Program has implemented many worthwhile initiatives, the anti-tobacco interventions do not appear to have exerted a noticeable effect on AAPI youth. Descriptors Adolescent, Asian Americans/statistics & numerical data, Child, Female, Florida/epidemiology, Humans, Male, Population Surveillance, Prevalence, Smoking/ethnology/trends, Surveys and Questionnaires, Texas/epidemiology, United States/epidemiology Links Book Title Database Publisher Data Source Authors Kershaw,J. M. Original/Translated Title URL Date of Electronic PMCID Editors
Promotion of waterpipe tobacco use, its variants and accessories in young adult newspapers: a content analysis of message portrayal	2015	Division of Health Promotion and Behavior, School of Public Health, Georgia State University, Atlanta, GA 30033, USA and Department of Behavioral and Community Health, School of Public Health, University of Maryland, College Park, MD 20742-2611, USA kster	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Health education research Periodical, Abbrev. Health Educ.Res. Pub Date Free Form Feb Volume 30 Issue 1 Start Page 152 Other Pages 161 Notes LR: 20160715; CI: (c) The Author 2014; GR: 1R03CA159909-01A1/CA/NCI NIH HHS/United States; GR: P20 MD006737/MD/NIMHD NIH HHS/United States; GR: R03 CA159909/CA/NCI NIH HHS/United States; GR: R21 CA180934/CA/NCI NIH HHS/United States; GR: R24 HD041041/HD/N Place of Publication England ISSN/ISBN 1465-3648; 0268-1153 Accession Number PMID: 24957675 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; T DOI 10.1093/her/cyu035 [doi] Output Language Unknown(0) PMID 24957675 Abstract The objective of our study was to identify waterpipe tobacco smoking advertisements and those that promoted a range of products and accessories used to smoke waterpipe tobacco. The content of these advertisements was analyzed to understand the messages portrayed about waterpipe tobacco smoking in young adult (aged 18-30) newspapers. The study methods include monitoring of six newspapers targeting young adults from four major cities in the Southeastern United States over a 6-month period. A total of 87 advertisements were found; 73.5% (64) were distinct and content analyzed. The study results showed that of the advertisements analyzed, 25% advertised waterpipe tobacco smoking, 54.7% featured waterpipe tobacco smoking and other tobacco use, 14.1% featured non-tobacco waterpipe variants (i.e. vaporizers), and 6.3% featured waterpipe apparatus accessories (e.g. charcoal, hoses). The sociability (34%) and sensuality (29.7%) of waterpipe smoking were promoted themes. Alternative to cigarette use messages (3.1%), and harm-reduction messages (17.1%) emphasized that smoking waterpipe tobacco using the featured accessory or waterpipe variant was a healthier experience than cigarette smoking. The study concluded that the messages that promoted waterpipe tobacco smoking to young adults are parallel to those used to promote cigarette use. Tobacco control professionals should continue to monitor young adult newspapers as a source of waterpipe-related advertising. Descriptors Links Book Title Database Publisher . Published by Oxford University Press Data Source Authors Sterling,K.L., Fryer,C.S., Majeed,B., Duong,M.M. Original/Translated Title URL Date of Electronic 20140623 PMCID PMC4296886 Editors
Biomarkers in neuroendocrine tumors	2013	Division of Hematology Oncology, Tufts Cancer Center. Boston, MA 02111, USA. dr.marvin.duque@hotmail.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full JOP : Journal of the pancreas Periodical, Abbrev. JOP Pub Date Free Form 10-Jul Volume 14 Issue 4 Start Page 372 Other Pages 376 Notes LR: 20151119; JID: 101091810; 0 (Biomarkers, Tumor); 0 (Chromogranin A); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.10.1 (Receptor, IGF Type 1); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); 2013/06/ Place of Publication Italy ISSN/ISBN 1590-8577; 1590-8577 Accession Number PMID: 23846930 Language eng SubFile Journal Article; IM DOI 10.6092/1590-8577/1692 [doi] Output Language Unknown(0) PMID 23846930 Abstract Neuroendocrine tumors are a heterogeneous group of tumors with cells of neuroendocrine differentiation that arise from diverse anatomic sites with varying morphologic and clinical features. Since the natural history and prognosis varies widely between individual neuroendocrine tumor types, there is a critical need to identify accurate prognostic and predictive biomarkers and markers predictive of therapeutic efficacy. To date, plasma chromogranin-A levels have generally been accepted as the most useful biomarker, despite the fact that there are substantial concerns in sensitivity and discrepancies in measurement techniques. As a consequence, considerable attention has been focused upon the development of novel biomarkers that can be utilized with more clinical efficacy than chromogranin-A. In addition to amplifying the diagnostic/prognostic landscape, the need to calibrate the efficacy of biological targeted therapy has further accelerated the development of molecular biomarkers. At the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, Chou et al. (Abstract #e15151) presented data that chromogranin A levels can be monitored during treatment to predict clinical outcome. Modlin et al. (Abstract #4137), demonstrated a promising novel biomarker, serum multi-transcript molecular signature. Grande et al. (Abstract #4140), Heetfield et al. (Abstract #e15071) and Casanovas et al. (Abstract #4139) described sVEGFR2, p-mTOR and IGF1R as molecular markers with potential for use in targeted therapy trials. The authors review and summarize these abstracts in this article. Descriptors Links Book Title Database Publisher Data Source Authors Duque,M., Modlin,I.M., Gupta,A., Saif,M.W. Original/Translated Title URL Date of Electronic 20130710 PMCID Editors
Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men	2008	Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Mailstop E-37, 1600 Clifton Road NE, Atlanta, GA 30333, USA. wdj0@cdc.gov	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Cochrane database of systematic reviews Periodical, Abbrev. Cochrane Database Syst.Rev. Pub Date Free Form 16-Jul Volume (3):CD001230. doi Issue 3 Start Page CD001230 Other Pages Notes LR: 20130628; JID: 100909747; RF: 245; epublish Place of Publication England ISSN/ISBN 1469-493X; 1361-6137 Accession Number PMID: 18646068 Language eng SubFile Journal Article; Meta-Analysis; Review; IM DOI 10.1002/14651858.CD001230.pub2 [doi] Output Language Unknown(0) PMID 18646068 Abstract BACKGROUND: Men who have sex with men (MSM) remain at great risk for HIV infection. Program planners and policy makers need descriptions of interventions and quantitative estimates of intervention effects to make informed decisions concerning prevention funding and research. The number of intervention strategies for MSM that have been examined with strong research designs has increased substantially in the past few years. OBJECTIVES: 1. To locate and describe outcome studies evaluating the effects of behavioral HIV prevention interventions for MSM.2. To summarize the effectiveness of these interventions in reducing unprotected anal sex.3. To identify study characteristics associated with effectiveness.4. To identify gaps and indicate future research, policy, and practice needs. SEARCH STRATEGY: We searched electronic databases, current journals, manuscripts submitted by researchers, bibliographies of relevant articles, conference proceedings, and other reviews for published and unpublished reports from 1988 through December 2007. We also asked researchers working in HIV prevention about new and ongoing studies. SELECTION CRITERIA: Studies were considered in scope if they examined the effects of behavioral interventions aimed at reducing risk for HIV or STD transmission among MSM. We reviewed studies in scope for criteria of outcome relevance (measurement of at least one of a list of behavioral or biologic outcomes, e.g., unprotected sex or incidence of HIV infections) and methodologic rigor (randomized controlled trials or certain strong quasi-experimental designs with comparison groups). DATA COLLECTION AND ANALYSIS: We used fixed and random effects models to summarize rate ratios (RR) comparing intervention and control groups with respect to count outcomes (number of occasions of or partners for unprotected anal sex), and corresponding prevalence ratios (PR) for dichotomous outcomes (any unprotected anal sex vs. none). We used published formulas to convert effect sizes and their variances for count and dichotomous outcomes where necessary. We accounted for intraclass correlation (ICC) in community-level studies and adjusted for baseline conditions in all studies. We present separate results by intervention format (small group, individual, or community-level) and by type of intervention delivered to the comparison group (minimal or no HIV prevention in the comparison condition versus standard or other HIV prevention in the comparison condition). We examine rate ratios stratified according to characteristics of participants, design, implementation, and intervention content. For small group and individual-level interventions we used a stepwise selection process to identify a multivariable model of predictors of reduction in occasions of or partners for unprotected anal sex. We used funnel plots to examine publication bias, and Q (a chi-squared statistic with degrees of freedom = number of interventions minus 1) to test for heterogeneity. MAIN RESULTS: We found 44 studies evaluating 58 interventions with 18,585 participants. Formats included 26 small group interventions, 21 individual-level interventions, and 11 community-level interventions. Sixteen of the 58 interventions focused on HIV-positives. The 40 interventions that were measured against minimal to no HIV prevention intervention reduced occasions of or partners for unprotected anal sex by 27% (95% confidence interval [CI] = 15% to 37%). The other 18 interventions reduced unprotected anal sex by 17% beyond changes observed in standard or other interventions (CI = 5% to 27%). Intervention effects were statistically homogeneous, and no independent variable was statistically significantly associated with intervention effects at alpha=.05. However, a multivariable model selected by backward stepwise elimination identified four study characteristics associated with reduction in occasions of or partners for unprotected anal sex among small group and individual-level interventi Descriptors HIV Infections/prevention & control/transmission, Health Knowledge, Attitudes, Practice, Homosexuality, Male, Humans, Male, Randomized Controlled Trials as Topic, Risk-Taking, Safe Sex, Sexually Transmitted Diseases/prevention & control Links Book Title Database Publisher Data Source Authors Johnson,W. D., Diaz,R. M., Flanders,W. D., Goodman,M., Hill,A. N., Holtgrave,D., Malow,R., McClellan,W. M. Original/Translated Title URL Date of Electronic 20080716 PMCID Editors
Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species	2008	Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form May Volume 52 Issue 5 Start Page 1884 Other Pages 1887 Notes LR: 20140904; JID: 0315061; 0 (Antifungal Agents); 7XU7A7DROE (Amphotericin B); OID: NLM: PMC2346666; 2008/02/19 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1098-6596; 0066-4804 Accession Number PMID: 18285487 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1128/AAC.01473-07 [doi] Output Language Unknown(0) PMID 18285487 Abstract Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms. Descriptors Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Biofilms/drug effects/growth & development, Candida/cytology/drug effects/growth & development, Drug Resistance, Fungal, Species Specificity Links Book Title Database Publisher Data Source Authors Al-Dhaheri,R. S., Douglas,L. J. Original/Translated Title URL Date of Electronic 20080219 PMCID PMC2346666 Editors
In vitro biofilm characterization and activity of antifungal agents alone and in combination against sessile and planktonic clinical Candida albicans isolates	2007	Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Diagnostic microbiology and infectious disease Periodical, Abbrev. Diagn.Microbiol.Infect.Dis. Pub Date Free Form Mar Volume 57 Issue 3 Start Page 277 Other Pages 281 Notes LR: 20141120; JID: 8305899; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Peptides, Cyclic); 0 (Pyrimidines); 0 (Triazoles); F0XDI6ZL63 (caspofungin); JFU09I87TR (Voriconazole); 2006/08/04 [received]; 2006/09/12 [revised]; 2006/09/15 [accepted]; 2006/12/01 Place of Publication United States ISSN/ISBN 0732-8893; 0732-8893 Accession Number PMID: 17141454 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI S0732-8893(06)00370-1 [pii] Output Language Unknown(0) PMID 17141454 Abstract Thirty clinical isolates of Candida albicans were collected from blood or other sterile site infections. Biofilm dry weight and metabolic activity were measured for each isolate. Planktonic and sessile antifungal susceptibilities of each isolate were determined for amphotericin B deoxycholate, caspofungin, and voriconazole. Sessile susceptibilities were determined for the combination of caspofungin/voriconazole. No significant differences in biofilm dry weight or metabolic activity were found between bloodstream and other invasive isolates. Planktonic MIC90 values and sessile MIC90 (SMIC90) values were 0.25 and 2, 0.06 and >256, and 0.5 and 2 microg/mL for amphotericin, voriconazole, and caspofungin, respectively. The SMIC90 of the combination of caspofungin/voriconazole against sessile isolates was 0.5/2 microg/mL. Therefore, the source of invasive C. albicans clinical isolates did not affect in vitro biofilm formation. Susceptibility to antifungal agents decreased when C. albicans was associated with biofilm, and the combination of caspofungin/voriconazole did not appear to provide enhanced activity compared with caspofungin alone. Descriptors Antifungal Agents/pharmacology, Biofilms/drug effects, Candida albicans/drug effects/physiology, Drug Therapy, Combination, Echinocandins, Humans, Microbial Sensitivity Tests/methods, Peptides, Cyclic/pharmacology, Pyrimidines/pharmacology, Triazoles/pharmacology, Voriconazole Links Book Title Database Publisher Data Source Authors Shuford,J. A., Piper,K. E., Steckelberg,J. M., Patel,R. Original/Translated Title URL Date of Electronic 20061201 PMCID Editors
Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins	2002	Division of Infectious Diseases, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Jun Volume 46 Issue 6 Start Page 1773 Other Pages 1780 Notes LR: 20140612; GR: AI-36219/AI/NIAID NIH HHS/United States; GR: AI07024/AI/NIAID NIH HHS/United States; GR: AI35097-03/AI/NIAID NIH HHS/United States; GR: P30 CA43703-12/CA/NCI NIH HHS/United States; JID: 0315061; 0 (Anti-Bacterial Agents); 0 (Antifungal A Place of Publication United States ISSN/ISBN 0066-4804; 0066-4804 Accession Number PMID: 12019089 Language eng SubFile Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; IM DOI Output Language Unknown(0) PMID 12019089 Abstract Biofilms, likely the predominant mode of device-related microbial infection, exhibit resistance to antimicrobial agents. Evidence suggests that Candida biofilms have dramatically reduced susceptibility to antifungal drugs. We examined antifungal susceptibilities of Candida albicans and Candida parapsilosis biofilms grown on a bioprosthetic model. In addition to conventional agents, we determined if new antifungal agents (triazoles, amphotericin B lipid formulations, and echinocandins) have activities against Candida biofilms. We also explored effects of preincubation of C. albicans cells with subinhibitory concentrations (sub-MICs) of drugs to see if they could modify subsequent biofilm formation. Finally, we used confocal scanning laser microscopy (CSLM) to image planktonic- and biofilm-exposed blastospores to examine drug effects on cell structure. Candida biofilms were formed on silicone elastomer and quantified by tetrazolium and dry weight (DW) assays. Susceptibility testing of fluconazole, nystatin, chlorhexidine, terbenafine, amphotericin B (AMB), and the triazoles voriconazole (VRC) and ravuconazole revealed resistance in all Candida isolates examined when grown as biofilms, compared to planktonic forms. In contrast, lipid formulations of AMB (liposomal AMB and AMB lipid complex [ABLC]) and echinocandins (caspofungin [Casp] and micafungin) showed activity against Candida biofilms. Preincubation of C. albicans cells with sub-MIC levels of antifungals decreased the ability of cells to subsequently form biofilm (measured by DW; P < 0.0005). CSLM analysis of planktonic and biofilm-associated blastospores showed treatment with VRC, Casp, and ABLC resulted in morphological alterations, which differed with each agent. In conclusion, our data show that Candida biofilms show unique susceptibilities to echinocandins and AMB lipid formulations. Descriptors Amphotericin B/administration & dosage/pharmacology, Anti-Bacterial Agents/pharmacology, Antifungal Agents/administration & dosage/pharmacology, Biofilms/drug effects, Candida/drug effects/ultrastructure, Culture Media, Drug Resistance, Microbial, Echinocandins, Fungal Proteins, Liposomes, Microbial Sensitivity Tests, Microscopy, Confocal, Peptides, Peptides, Cyclic, Polyenes/pharmacology, Prosthesis-Related Infections/microbiology, Triazoles/pharmacology Links Book Title Database Publisher Data Source Authors Kuhn,D. M., George,T., Chandra,J., Mukherjee,P. K., Ghannoum,M. A. Original/Translated Title URL Date of Electronic PMCID PMC127206 Editors
Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species	2007	Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Sep Volume 51 Issue 9 Start Page 3081 Other Pages 3088 Notes LR: 20140904; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Tetrazolium Salts); 117038-70-7 (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazoliu m hydroxide); F0XDI6ZL63 (caspofungin); OID: NLM: PMC2043224; 2007/0 Place of Publication United States ISSN/ISBN 0066-4804; 0066-4804 Accession Number PMID: 17591847 Language eng SubFile Journal Article; IM DOI AAC.00676-07 [pii] Output Language Unknown(0) PMID 17591847 Abstract The paradoxical growth (PG) of Candida sp. biofilms in the presence of high caspofungin (CAS) concentrations was previously unknown. We sought to characterize the PG at supra-MICs of CAS among clinical Candida sp. isolates grown as biofilms in 96-well polystyrene microtiter plates. The MICs of CAS were determined for 30 clinical Candida sp. isolates (4 Candida albicans, 6 C. tropicalis, 7 C. parapsilosis, 8 C. orthopsilosis, and 5 C. metapsilosis isolates) when they were grown as planktonic cells and biofilms and were defined as the lowest drug concentrations that resulted in a prominent decrease in growth and a 50% reduction in metabolic activity, respectively. PG was defined as a resurgence of growth (>50% of that in the drug-free growth control well) at drug concentrations above the MIC. With the exception of C. tropicalis, all isolates displayed PG more frequently when they were grown as biofilms than when they grown as planktonic cells. PG was undetectable among C. metapsilosis isolates in planktonic cell MIC tests but was present in 100% of the isolates in biofilm MIC tests. The drug concentration and the number of drug dilutions supporting PG were higher for biofilms than for planktonic cells. Microscopic changes in cell morphology were observed among both planktonic and biofilm cells with PG. Specifically, the accumulation of enlarged, globose cells was associated with PG, and we hypothesize that CAS-induced changes in the cell wall composition may be the explanation. Descriptors Antifungal Agents/pharmacology, Biofilms/drug effects, Candida/drug effects/growth & development/physiology, Candidiasis/microbiology, Echinocandins/pharmacology, Microbial Sensitivity Tests, Risk, Tetrazolium Salts Links Book Title Database Publisher Data Source Authors Melo,A. S., Colombo,A. L., Arthington-Skaggs,B. A. Original/Translated Title URL Date of Electronic 20070625 PMCID PMC2043224 Editors
In vitro analyses of the combination of high-dose doxycycline and antifungal agents against Candida albicans biofilms	2009	Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM 87108, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full International journal of antimicrobial agents Periodical, Abbrev. Int.J.Antimicrob.Agents Pub Date Free Form Oct Volume 34 Issue 4 Start Page 326 Other Pages 332 Notes LR: 20140603; GR: T32 AI007538/AI/NIAID NIH HHS/United States; JID: 9111860; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL63 (caspofungin); N12000U13O (Doxycycline); 2009/01/18 [received]; 2009/0 Place of Publication Netherlands ISSN/ISBN 1872-7913; 0924-8579 Accession Number PMID: 19515537 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI 10.1016/j.ijantimicag.2009.04.011 [doi] Output Language Unknown(0) PMID 19515537 Abstract The potential of antifungal agents used as antimicrobial lock therapy (ALT) for the conservative management of catheter-related candidemia has not been fully defined. We sought to determine the antifungal effect of high-dose doxycycline (DOX), alone or in combination with standard concentrations of amphotericin B (AMB), caspofungin (CAS) or fluconazole (FLC), against biofilms formed by Candida albicans in vitro. DOX alone (at 2048 microg/mL and 1024 microg/mL) demonstrated up to an 85% reduction of the metabolic activity of the C. albicans biofilm. Regardless of the concentration tested, FLC alone showed minimal activity (mean 22.9% reduction) against the C. albicans biofilm. When DOX 2048 microg/mL was used in combination with FLC, antifungal activity also increased up to 85%, suggesting an additive effect. DOX 128 microg/mL in combination with FLC demonstrated synergy (mean 58.3% reduction). The combination of DOX 2048 microg/mL or 512 microg/mL and AMB was superior to AMB alone at low concentrations (0.25-0.03125 microg/mL). However, DOX 128 microg/mL was antagonistic in combination with low concentrations of AMB. Maximal efficacy against the biofilm was observed with CAS at 8-0.25 microg/mL compared with FLC and AMB alone. A paradoxical effect (PE) occurred with CAS at 16 microg/mL, which showed a marked reduction in antifungal activity compared with lower concentrations of CAS. CAS at 16 microg/mL in combination with either DOX 2048 microg/mL or 512 microg/mL resulted in attenuation of the PE. These findings suggest that a high-dose DOX-based ALT strategy in combination with traditional antifungal agents may be useful for the treatment of C. albicans biofilms. Descriptors Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Biofilms/drug effects, Candida albicans/drug effects, Dose-Response Relationship, Drug, Doxycycline/administration & dosage/pharmacology, Drug Interactions, Drug Therapy, Combination, Echinocandins/pharmacology, Fluconazole/pharmacology, Humans, Microbial Sensitivity Tests Links Book Title Database Publisher Data Source Authors Miceli,M. H., Bernardo,S. M., Lee,S. A. Original/Translated Title URL Date of Electronic 20090609 PMCID Editors
Prevalence and Predictors of Gastroesophageal Reflux Complications in Community Subjects	2016	Division of Internal Medicine, Mayo Clinic, Rochester, MN, USA.; Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.; Division of Biomedical Statistics and Informatics, Mayo Clinic,	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Digestive diseases and sciences Periodical, Abbrev. Dig.Dis.Sci. Pub Date Free Form 10-Aug Volume Issue Start Page Other Pages Notes LR: 20160811; JID: 7902782; OTO: NOTNLM; 2016/04/19 [received]; 2016/07/22 [accepted]; 2016/08/10 [aheadofprint]; aheadofprint Place of Publication ISSN/ISBN 1573-2568; 0163-2116 Accession Number PMID: 27510751 Language ENG SubFile JOURNAL ARTICLE DOI 10.1007/s10620-016-4266-3 [doi] Output Language Unknown(0) PMID 27510751 Abstract BACKGROUND: Predictors of erosive esophagitis (EE) and Barrett's esophagus (BE) and the influence of number of risk factors in the community are not well defined. METHODS: Rates of BE and EE among community residents identified in a randomized screening trial were defined. The risk of EE and BE associated with single and multiple risk factors (gender, age, GERD, Caucasian ethnicity, ever tobacco use, excess alcohol use, family history of BE or EAC, and central obesity) was analyzed. RESULTS: Sixty-eight (33 %) of 205 subjects had EE and/or BE. BE prevalence was 7.8 % with dysplasia present in 1.5 %. Rates were comparable between subjects with and without GERD. Male sex and central obesity were independent risk factors. The odds of EE or BE were 3.7 times higher in subjects with three or four risk factors and 5.7 times higher in subjects with five or more risk factors compared with those with two or less factors. CONCLUSIONS: EE and BE are prevalent in the community regardless of the presence of GERD. Risk appeared to be additive, increasing substantially with three or more risk factors. Descriptors Links Book Title Database Publisher Data Source Authors Crews,N.R., Johnson,M.L., Schleck,C.D., Enders,F.T., Wongkeesong,L.M., Wang,K.K., Katzka,D.A., Iyer,P.G. Original/Translated Title URL Date of Electronic 20160810 PMCID Editors

E-mail