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Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles 2013 School of Life Sciences, SRTM University, Nanded, MS 431606, India.
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Journal Article
Periodical, Full
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Periodical, Abbrev.
Braz.J.Infect.Dis.
Pub Date Free Form
Jul-Aug
Volume
17
Issue
4
Start Page
395
Other Pages
400
Notes
CI: Copyright (c) 2013; JID: 9812937; 0 (Antifungal Agents); 0 (Azoles); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 886U3H6UFF (Chloroquine); F0XDI6ZL63 (caspofungin); OTO: NOTNLM; 2012/07/26 [received]; 2012/10/31 [revised]; 2012/11/01 [accepted]; 2
Place of Publication
Brazil
ISSN/ISBN
1678-4391; 1413-8670
Accession Number
PMID: 23602464
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.bjid.2012.11.002 [doi]
Output Language
Unknown(0)
PMID
23602464
Abstract
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic assay were confirmed by scanning electron microscopy. The interactions between chloroquine and four antifungal drugs were determined by calculating fractional inhibitory concentration indices. Azole resistance in biofilms was reverted significantly (p
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Book Title
Database
Publisher
Elsevier Editora Ltda
Data Source
Authors
Shinde,R.B., Raut,J.S., Chauhan,N.M., Karuppayil,S.M.
Original/Translated Title
URL
Date of Electronic
20130418
PMCID
Editors
On the role of abnormal DL(CO) in ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI 2013 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
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Print(0)
Ref Type
Journal Article
Periodical, Full
Thorax
Periodical, Abbrev.
Thorax
Pub Date Free Form
Aug
Volume
68
Issue
8
Start Page
752
Other Pages
759
Notes
LR: 20151119; GR: CIF#97687/Canadian Institutes of Health Research/Canada; JID: 0417353; 0 (Antimetabolites); 206GF3GB41 (Helium); 7U1EE4V452 (Carbon Monoxide); OTO: NOTNLM; 2013/04/19 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1468-3296; 0040-6376
Accession Number
PMID: 23604381
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1136/thoraxjnl-2012-203108 [doi]
Output Language
Unknown(0)
PMID
23604381
Abstract
BACKGROUND: The functional effects of abnormal diffusing capacity for carbon monoxide (DLCO) in ex-smokers without chronic obstructive pulmonary disease (COPD) are not well understood. OBJECTIVE: We aimed to evaluate and compare well established clinical, physiological and emerging imaging measurements in ex-smokers with normal spirometry and abnormal DLCO with a group of ex-smokers with normal spirometry and DLCO and ex-smokers with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I COPD. METHODS: We enrolled 38 ex-smokers and 15 subjects with stage I COPD who underwent spirometry, plethysmography, St George's Respiratory Questionnaire (SGRQ), 6 min Walk Test (6MWT), x-ray CT and hyperpolarised helium-3 ((3)He) MRI. The 6MWT distance (6MWD), SGRQ scores, (3)He MRI apparent diffusion coefficients (ADC) and CT attenuation values below -950 HU (RA950) were evaluated. RESULTS: Of 38 ex-smokers without COPD, 19 subjects had abnormal DLCO with significantly worse ADC (p=0.01), 6MWD (p=0.008) and SGRQ (p=0.01) but not RA950 (p=0.53) compared with 19 ex-smokers with normal DLCO. Stage I COPD subjects showed significantly worse ADC (p=0.02), RA950 (p=0.0008) and 6MWD (p=0.005), but not SGRQ (p=0.59) compared with subjects with abnormal DLCO. There was a significant correlation for (3)He ADC with SGRQ (r=0.34, p=0.02) and 6MWD (r=-0.51, p=0.0002). CONCLUSIONS: In ex-smokers with normal spirometry and CT but abnormal DLCO, there were significantly worse symptoms, 6MWD and (3)He ADC compared with ex-smokers with normal DLCO, providing evidence of the impact of mild or early stage emphysema and a better understanding of abnormal DLCO and hyperpolarised (3)He MRI in ex-smokers without COPD.
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Database
Publisher
Data Source
Authors
Kirby,M., Owrangi,A., Svenningsen,S., Wheatley,A., Coxson,H.O., Paterson,N.A., McCormack,D.G., Parraga,G.
Original/Translated Title
URL
Date of Electronic
20130419
PMCID
Editors
Change of secondhand smoke levels in a public hospital in Budapest after implementation of anti-smoking policy in 2011 2013 Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Radiologiai es Onkoterapias Klinika, Budapest, Ulloi ut 78/A 1082.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Orvosi hetilap
Periodical, Abbrev.
Orv.Hetil.
Pub Date Free Form
28-Apr
Volume
154
Issue
17
Start Page
658
Other Pages
664
Notes
JID: 0376412; 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
Hungary
ISSN/ISBN
0030-6002; 0030-6002
Accession Number
PMID: 23608313
Language
hun
SubFile
English Abstract; Journal Article; IM
DOI
10.1556/OH.2013.29594 [doi]
Output Language
Unknown(0)
PMID
23608313
Abstract
INTRODUCTION: Our previous 2009 study demonstrated high secondhand smoke levels throughout a public hospital in Budapest. AIM: To compare changes in indoor air pollution level between 2009 and 2012, before and after the Hungarian anti-smoking policy legislation adopted in 2011. METHODS: TSI SidePak AM510 Personal Aerosol Monitor was used. RESULTS: In-patient care department PM2.5 levels declined by 92% from 87.7 mug/m3 to 6.9 mug/m3. Non-patient care area PM2.5 level increased by 67% from 64.8 mug/m3 to 108.0 mug/m3. The increase was driven entirely by a large increase in the level in public toilets. Excluding these, there was a 83% drop in PM2.5 in non-patient care areas from 64.8 mug/m3 to 11.1 mug/m3. CONCLUSIONS: PM2.5 decreased significantly due to the 2011 law. However, smoking still occurred in the hospital, albeit in less frequently visited areas. A stricter enforcement of this beneficial law is needed to reach a comprehensive smoke-free hospital environment.
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Authors
Tarnoki,D.L., Tarnoki,A.D., Csathy,L., Travers,M.J.
Original/Translated Title
Dohanyfust-koncentracio valtozasa egy budapesti kozkorhazban a nemdohanyzok vedelmet celzo 2011-es torvenyt kovetoen
URL
Date of Electronic
PMCID
Editors
CO exposure and puff topography are associated with Lebanese waterpipe dependence scale score 2013 Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan;
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Oct
Volume
15
Issue
10
Start Page
1782
Other Pages
1786
Notes
LR: 20150427; GR: R01 DA025659/DA/NIDA NIH HHS/United States; GR: R01CA120142/CA/NCI NIH HHS/United States; GR: R01DA025659/DA/NIDA NIH HHS/United States; GR: R03TW008371./TW/FIC NIH HHS/United States; JID: 9815751; 0 (Tobacco Smoke Pollution); 7U1EE4V452
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 23616231
Language
eng
SubFile
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; IM
DOI
10.1093/ntr/ntt049 [doi]
Output Language
Unknown(0)
PMID
23616231
Abstract
INTRODUCTION: Waterpipe tobacco smoking involves self-administration of the dependence-producing drug nicotine. Few studies have examined if dependence in waterpipe smokers influences toxicant exposure and smoking behavior. METHOD: Current waterpipe tobacco smokers were categorized based on Lebanese Waterpipe Dependence Scale-11 (LWDS-11) score (LWDS-11: LOW 13; N = 59). Participants abstained from smoking for 12 hr and then completed a single 30-min waterpipe tobacco smoking episode. Expired-air carbon monoxide (CO) was measured before and 5 min after smoking and puff topography was measured during smoking. RESULTS: Total mean smoking time was 30.9 min (SD = 3.5) and did not differ significantly by LWDS-11 score. CO boost was greater for participants in the HIGH versus LOW groups (62.3 vs. 43.6 ppm, p
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Data Source
Authors
Alzoubi,K.H., Khabour,O.F., Azab,M., Shqair,D.M., Shihadeh,A., Primack,B., Eissenberg,T.
Original/Translated Title
URL
Date of Electronic
20130424
PMCID
PMC3842104
Editors
Impact of temperature and storage duration on the chemical and odor quality of military packaged water in polyethylene terephthalate bottles 2013 Department of Preventive Medicine and Biometrics, 4301 Jones Bridge Road, Uniformed Services University of Health Sciences, Bethesda, MD 20814 USA. Michael.Greifenstein@us.army.mil
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Science of the total environment
Periodical, Abbrev.
Sci.Total Environ.
Pub Date Free Form
1-Jul
Volume
456-457
Issue
Start Page
376
Other Pages
383
Notes
CI: Copyright (c) 2013; JID: 0330500; 0 (Drinking Water); 0 (Polyethylene Terephthalates); 0 (Water Pollutants, Chemical); 2013/01/06 [received]; 2013/03/06 [revised]; 2013/03/25 [accepted]; 2013/04/30 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1879-1026; 0048-9697
Accession Number
PMID: 23624011
Language
eng
SubFile
Journal Article; IM
DOI
10.1016/j.scitotenv.2013.03.092 [doi]
Output Language
Unknown(0)
PMID
23624011
Abstract
The impact of temperature and storage time on military packaged water (MPW) quality was examined at four temperatures (23.0 degrees C to 60.0 degrees C) for 120 days. Polyethylene terephthalate (PET) bottles were filled in California and Afghanistan with unbuffered water treated by reverse osmosis. The US military's water pH long-term potability standard was exceeded, and US Food and Drug Administration (USFDA) and US Environmental Protection Agency (USEPA) drinking water pH and odor intensity limits were also exceeded. During a 70 day exposure period, Port Hueneme MPW total organic carbon and total trihalomethane levels increased from
Descriptors
Links
Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Greifenstein,M., White,D.W., Stubner,A., Hout,J., Whelton,A.J.
Original/Translated Title
URL
Date of Electronic
20130430
PMCID
Editors
Relationship between amount of cigarette smoking and coronary atherosclerosis on coronary CTA in asymptomatic individuals 2013 Division of Cardiovascular Imaging, Department of Radiology, Seoul National University Bundang Hospital, Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The international journal of cardiovascular imaging
Periodical, Abbrev.
Int.J.Cardiovasc.Imaging
Pub Date Free Form
Jun
Volume
29 Suppl 1
Issue
Start Page
21
Other Pages
28
Notes
JID: 100969716; 2013/03/15 [received]; 2013/04/19 [accepted]; 2013/04/27 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1875-8312; 1569-5794
Accession Number
PMID: 23624929
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1007/s10554-013-0224-8 [doi]
Output Language
Unknown(0)
PMID
23624929
Abstract
Current smoking is a powerful independent predictor of coronary atherosclerosis in asymptomatic individuals. Many researchers have suggested a cigarette dose-response relationship between smoking and subclinical coronary atherosclerosis. Our study purposes were (a) to investigate the prevalence and plaque characteristics of coronary atherosclerosis in asymptomatic smokers and (b) to assess the cigarette dose-response relationship between smoking and subclinical coronary atherosclerosis using coronary CT angiography (CTA). We consecutively enrolled 7,104 self-referred asymptomatic subjects who underwent coronary CTA as part of a general health evaluation. Current smokers (n = 1,784) were categorized according to total pack years (TPY) with four grades (A, 0.1-10; B, 10-20; C, 20-30; D, >30), smoking duration (SD, years) with four grades (A, 0.1-10; B, 10-20; C, 20-30; D, >30), and number of cigarettes per day (CPD) with four grades (A, 1-20; B, 10-20; C, 20-40; D, >40). After adjusting for other cardiovascular risk factors, adjusted odds ratios for current smokers versus never-smokers as a control group were estimated for the presence of plaques, significant stenosis, and non-calcified plaques (NCP). Current smokers had a statistically significant higher prevalence of any plaque, significant stenosis, NCP, and coronary artery calcium score >100 than never-smokers. According to each categorization of TPY, SD, and CPD, the subclinical coronary atherosclerosis risk increased as grades increased in asymptomatic current smokers relative to never-smokers after adjusting for variable clinical and chemical risk factors. Our study suggests a cigarette dose-response relationship between current smoking and coronary atherosclerosis in asymptomatic individuals.
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Database
Publisher
Data Source
Authors
Kim,J.A., Chun,E.J., Lee,M.S., Kim,K.J., Choi,S.I.
Original/Translated Title
URL
Date of Electronic
20130427
PMCID
Editors
Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia 2013 Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia, rimkhlifi@yahoo.fr.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environmental science and pollution research international
Periodical, Abbrev.
Environ.Sci.Pollut.Res.Int.
Pub Date Free Form
Nov
Volume
20
Issue
11
Start Page
8282
Other Pages
8294
Notes
JID: 9441769; 0 (Environmental Pollutants); 0R0008Q3JB (Chromium); 7OV03QG267 (Nickel); CIN: Environ Sci Pollut Res Int. 2013 Nov;20(11):8297. PMID: 23975708; CIN: Environ Sci Pollut Res Int. 2013 Nov;20(11):8295-6. PMID: 23807563; 2012/10/08 [received];
Place of Publication
Germany
ISSN/ISBN
1614-7499; 0944-1344
Accession Number
PMID: 23625117
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1007/s11356-013-1466-7 [doi]
Output Language
Unknown(0)
PMID
23625117
Abstract
Chronic exposure to chromium (Cr) and nickel (Ni) has long been recognized as being capable to increase head and neck cancer (HNC) incidence among exposed human populations. This study represents the first biomonitoring of Cr and Ni exposure in Tunisia and focuses on a possible association with HNC risk. The aim of the present study was to evaluate the concentrations of Cr and Ni in the blood of HNC patients and controls. Metals blood levels of 169 HNC patients and 351 controls were determined using a Perkin-Elmer Analyst 800 Atomic Absorption Spectrometer. Mean blood levels of Cr and Ni in HNC cases (52.15 and 111.60 mug/L, respectively) were significantly higher than those of controls (37.04 and 30.50 mug/L, respectively). Cases' blood levels of Cr and Ni were significantly higher than those of controls after controlling for the other risk factors of HNC, including smoking, shisha consumption, occupational exposure, and nearby environment (P
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Khlifi,R., Olmedo,P., Gil,F., Feki-Tounsi,M., Chakroun,A., Rebai,A., Hamza-Chaffai,A.
Original/Translated Title
URL
Date of Electronic
20130428
PMCID
Editors
School-based programmes for preventing smoking 2013 Department of Family Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada. rthomas@ucalgary.ca.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Cochrane database of systematic reviews
Periodical, Abbrev.
Cochrane Database Syst.Rev.
Pub Date Free Form
30-Apr
Volume
(4):CD001293. doi
Issue
4
Start Page
CD001293
Other Pages
Notes
LR: 20160602; JID: 100909747; epublish
Place of Publication
England
ISSN/ISBN
1469-493X; 1361-6137
Accession Number
PMID: 23633306
Language
eng
SubFile
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.1002/14651858.CD001293.pub3 [doi]
Output Language
Unknown(0)
PMID
23633306
Abstract
BACKGROUND: Helping young people to avoid starting smoking is a widely endorsed public health goal, and schools provide a route to communicate with nearly all young people. School-based interventions have been delivered for close to 40 years. OBJECTIVES: The primary aim of this review was to determine whether school smoking interventions prevent youth from starting smoking. Our secondary objective was to determine which interventions were most effective. This included evaluating the effects of theoretical approaches; additional booster sessions; programme deliverers; gender effects; and multifocal interventions versus those focused solely on smoking. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), the Cochrane Tobacco Addiction Group's Specialised Register, MEDLINE, EMBASE, PsycINFO, ERIC, CINAHL, Health Star, and Dissertation Abstracts for terms relating to school-based smoking cessation programmes. In addition, we screened the bibliographies of articles and ran individual MEDLINE searches for 133 authors who had undertaken randomised controlled trials in this area. The most recent searches were conducted in October 2012. SELECTION CRITERIA: We selected randomised controlled trials (RCTs) where students, classes, schools, or school districts were randomised to intervention arm(s) versus a control group, and followed for at least six months. Participants had to be youth (aged 5 to 18). Interventions could be any curricula used in a school setting to deter tobacco use, and outcome measures could be never smoking, frequency of smoking, number of cigarettes smoked, or smoking indices. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed studies for inclusion, extracted data and assessed risk of bias. Based on the type of outcome, we placed studies into three groups for analysis: Pure Prevention cohorts (Group 1), Change in Smoking Behaviour over time (Group 2) and Point Prevalence of Smoking (Group 3). MAIN RESULTS: One hundred and thirty-four studies involving 428,293 participants met the inclusion criteria. Some studies provided data for more than one group.Pure Prevention cohorts (Group 1) included 49 studies (N = 142,447). Pooled results at follow-up at one year or less found no overall effect of intervention curricula versus control (odds ratio (OR) 0.94, 95% confidence interval (CI) 0.85 to 1.05). In a subgroup analysis, the combined social competence and social influences curricula (six RCTs) showed a statistically significant effect in preventing the onset of smoking (OR 0.49, 95% CI 0.28 to 0.87; seven arms); whereas significant effects were not detected in programmes involving information only (OR 0.12, 95% CI 0.00 to 14.87; one study), social influences only (OR 1.00, 95% CI 0.88 to 1.13; 25 studies), or multimodal interventions (OR 0.89, 95% CI 0.73 to 1.08; five studies). In contrast, pooled results at longest follow-up showed an overall significant effect favouring the intervention (OR 0.88, 95% CI 0.82 to 0.96). Subgroup analyses detected significant effects in programmes with social competence curricula (OR 0.52, 95% CI 0.30 to 0.88), and the combined social competence and social influences curricula (OR 0.50, 95% CI 0.28 to 0.87), but not in those programmes with information only, social influence only, and multimodal programmes.Change in Smoking Behaviour over time (Group 2) included 15 studies (N = 45,555). At one year or less there was a small but statistically significant effect favouring controls (standardised mean difference (SMD) 0.04, 95% CI 0.02 to 0.06). For follow-up longer than one year there was a statistically nonsignificant effect (SMD 0.02, 95% CI -0.00 to 0.02).Twenty-five studies reported data on the Point Prevalence of Smoking (Group 3), though heterogeneity in this group was too high for data to be pooled.We were unable to analyse data for 49 studies (N = 152,544).Subgroup analyses (Pure Prevention cohorts only) demonstrated that at longe
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Thomas,R.E., McLellan,J., Perera,R.
Original/Translated Title
URL
Date of Electronic
20130430
PMCID
Editors
Coronary computed tomography angiography-adapted Leaman score as a tool to noninvasively quantify total coronary atherosclerotic burden 2013 Cardiology Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal, paraujogoncalves@yahoo.co.uk.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The international journal of cardiovascular imaging
Periodical, Abbrev.
Int.J.Cardiovasc.Imaging
Pub Date Free Form
Oct
Volume
29
Issue
7
Start Page
1575
Other Pages
1584
Notes
JID: 100969716; 2013/04/19 [received]; 2013/04/24 [accepted]; 2013/05/01 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1875-8312; 1569-5794
Accession Number
PMID: 23636301
Language
eng
SubFile
Journal Article; IM
DOI
10.1007/s10554-013-0232-8 [doi]
Output Language
Unknown(0)
PMID
23636301
Abstract
To describe a coronary computed tomography angiography (CCTA)-adapted Leaman score (CT-LeSc) as a tool to quantify total coronary atherosclerotic burden with information regarding localization, type of plaque and degree of stenosis and to identify clinical predictors of a high coronary atherosclerotic burden as assessed by the CT-LeSc. Single center prospective registry including a total of 772 consecutive patients undergoing CCTA (Dual-source CT) from April 2011 to March 2012. For the purpose of this study, 581 stable patients referred for suspected coronary artery disease (CAD) without previous myocardial infarction or revascularization procedures were included. Pre-test CAD probability was determined using both the Diamond-Forrester extended CAD consortium method (DF-CAD consortium model) and the Morise score. Cardiovascular risk was assessed with the HeartScore. The cut-off for the 3rd tercile (CT-LeSc >/=8.3) was used to define a population with a high coronary atherosclerotic burden. The median CT-LeSc in this population (n = 581, 8,136 coronary segments evaluated; mean age 57.6 +/- 11.1; 55.8 % males; 14.6 % with diabetes) was 2.2 (IQR 0-6.8). In patients with CAD (n = 341), the median CT-LeSc was 5.8 (IQR 3.2-9.6). Among patients with nonobstructive CAD, most were classified in the lowest terciles (T1, 43.0 %; T2, 36.1 %), but 20.9 % were in the highest tercile (T3). The majority of the patients with obstructive CAD were classified in T3 (78.2 %), but 21.8 % had a CT-LeSc in lower terciles (T1 or T2). The independent predictors of a high CT-LeSc were: Male sex (OR 1.73; 95 % CI 1.04-2.90) diabetes (OR 2.91; 95 % CI 1.61-5.23), hypertension (OR 2.54; 95 % CI 1.40-4.63), Morise score >/= 16 (OR 1.97; 95 % CI 1.06-3.67) and HeartScore >/= 5 (OR 2.42; 95 % CI 1.41-4.14). We described a cardiac CT adapted Leaman score as a tool to quantify total (obstructive and nonobstructive) coronary atherosclerotic burden, reflecting the comprehensive information about localization, degree of stenosis and type of plaque provided by CCTA. Male sex, hypertension, diabetes, a HeartScore >/=5 % and a Morise score >/= 16 were associated with a high coronary atherosclerotic burden, as assessed by the CT-LeSc. About one fifth of the patients with nonobstructive CAD had a CT-LeSc in the highest tercile, and this could potentially lead to a reclassification of the risk profile of this subset of patients identified by CCTA, once the prognostic value of the CT-LeSc is validated.
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Authors
de Araujo Goncalves,P., Garcia-Garcia,H.M., Dores,H., Carvalho,M.S., Jeronimo Sousa,P., Marques,H., Ferreira,A., Cardim,N., Campante Teles,R., Raposo,L., Mesquita Gabriel,H., Sousa Almeida,M., Aleixo,A., Mota Carmo,M., Pereira Machado,F., Mendes,M.
Original/Translated Title
URL
Date of Electronic
20130501
PMCID
Editors
Relationship between chronic obstructive pulmonary disease and subclinical coronary artery disease in long-term smokers 2013 Department of Cardiology, Section 2012, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
European heart journal cardiovascular Imaging
Periodical, Abbrev.
Eur.Heart J.Cardiovasc.Imaging
Pub Date Free Form
Dec
Volume
14
Issue
12
Start Page
1159
Other Pages
1166
Notes
LR: 20160511; JID: 101573788; OTO: NOTNLM; 2013/05/02 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
2047-2412; 2047-2404
Accession Number
PMID: 23639550
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ehjci/jet057 [doi]
Output Language
Unknown(0)
PMID
23639550
Abstract
AIMS: Cardiovascular conditions are reported to be the most frequent cause of death in patients with chronic obstructive pulmonary disease (COPD). However, it remains unsettled whether severity of COPD per se is associated with coronary artery disease (CAD) independent of traditional cardiovascular risk factors. The aim of this study was to examine the relationship between the presence and severity of COPD and the amount of coronary artery calcium deposit, an indicator of CAD and cardiac risk, in a large population of current and former long-term smokers. METHODS AND RESULTS: In this cross-sectional study, long-term smokers without clinically manifested CAD were recruited from the Danish Lung Cancer Screening Trial and classified according to lung function by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Coronary artery calcium deposit as a measure of subclinical CAD and cardiac risk was evaluated with multi detector computed tomography and the Agatston coronary artery calcium score (CACS). Participants were categorized into five CACS risk classification groups according to the CACS. The population (n = 1535) consisted of 41% participants without COPD, 28% with mild, and 31% with moderate-to-severe COPD (n = 46 with severe COPD). In addition to age, male gender, hypertension, hypercholesterolaemia, and continued smoking, COPD according to GOLD classification were independent predictors of a higher CACS risk classification group in multivariable analysis [odds ratio (OR): 1.28 (1.01-1.63) and OR: 1.32 (1.05-1.67), for mild and moderate-to-severe COPD, respectively, compared with no COPD]. CONCLUSION: COPD in long-term smokers is independently correlated with the CACS, while COPD severity per se does not show a dose-response relationship.
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Authors
Rasmussen,T., Kober,L., Pedersen,J.H., Dirksen,A., Thomsen,L.H., Stender,S., Brodersen,J., Groen,J., Ashraf,H., Kofoed,K.F.
Original/Translated Title
URL
Date of Electronic
20130502
PMCID
Editors