WTS database

Title Sort descending	Pub Year	Author	SearchLink
Medical students' attitudes towards tobacco smoking at the first and sixth year of their studies 2002-2008	2009	Klinika Alergologii Gdanskiego Uniwersytetu Medycznego, Gdansk. asieminska@amg.gda.pl	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pneumonologia i alergologia polska Periodical, Abbrev. Pneumonol.Alergol.Pol. Pub Date Free Form Volume 77 Issue 4 Start Page 371 Other Pages 379 Notes LR: 20151119; JID: 9302892; CIN: Pneumonol Alergol Pol. 2010;78(2):176-81; author reply 182-5. PMID: 20306430; ppublish Place of Publication Poland ISSN/ISBN 0867-7077; 0867-7077 Accession Number PMID: 19722142 Language pol SubFile English Abstract; Journal Article; IM DOI Output Language Unknown(0) PMID 19722142 Abstract INTRODUCTION: Smoking habit among medical students indicates that studying of medicine does not sufficiently protect from tobacco use. The aim of the study was an analysis of medical students' attitudes towards smoking during at the first and sixth year of their studies. MATERIAL AND METHODS: A questionnaire on tobacco smoking was distributed among medical students of the study year 2002-2008 at the first and sixth year of their studies. The questionnaire used on sixth year included additional questions which enabled to assess changes in students' attitudes towards smoking during studies, to know respondents opinion on teaching of diagnostics and treatment of tobacco dependence (TD), and to know how they evaluated their knowledge on this issue. The numbers of students who participated at two points of the study were 287 and 175 respectively. RESULTS: Students of VI year significantly less frequently smoked cigarettes regularly than at the beginning of the medical education (13% v. 21%; p=0.022). However, 20% of smokers started smoking during studies. The rate of smokers declaring not to be embarrassed by their smoking habit was significantly lower among sixth-year students in comparison to population of first-year students (31% v. 70%; p=0.0006), as well as the rates of those who declared the will to quit smoking (91% v. 61%), and those who wished to undergo treatment for TD (54% v. 22%) were significantly higher (p=0.013 and p=0.001, respectively). Over a half (57%) of sixth-year students claimed that they had no knowledge on the diagnostics and treatment of TD or their knowledge on this issue was poor/very poor, and in opinion of 43% of students medical curriculum was not a good source of knowledge on TD. CONCLUSIONS: Medical studies induce positive students' attitudes towards smoking. However, a proportion of individuals start smoking during studies, what may suggest dominance of genetic influences on smoking initiation in this period of life. In sixth-year students' opinion medical studies are not a sufficient source of knowledge on TD. Descriptors Adult, Attitude to Health, Chi-Square Distribution, Female, Health Behavior, Humans, Male, Poland/epidemiology, Prevalence, Sex Distribution, Smoking/epidemiology/prevention & control/psychology, Socioeconomic Factors, Students, Medical/psychology/statistics & numerical data, Surveys and Questionnaires, Time Factors, Tobacco Use Disorder/epidemiology/prevention & control/psychology, Universities, Young Adult Links Book Title Database Publisher Data Source Authors Sieminska,A., Jassem-Bobowicz,J. M., Uherek,M., Wilanowski,T., Nowak,R., Jassem,E. Original/Translated Title Postawy wobec palenia tytoniu wsrod studentow I i VI roku medycyny z rocznika studiow 2002-2008 URL Date of Electronic PMCID Editors
Medicinal plants of Cariris Velhos, Paraiba, Part II: Subclass Magnoliidae, Caryophyllidae, Dilleniidae and Rosidae	1996	De Fatima Agra, M., Lab. de Tecnologia Farmaceutica, Universidade Federal de Paraiba, 58.051-970 Joao Pessoa, PB, Brazil	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Revista Brasileira de Farmacia Periodical, Abbrev. REV.BRAS.FARM. Pub Date Free Form 1996/ Volume 77 Issue 3 Start Page 97 Other Pages 102 Notes Place of Publication ISSN/ISBN 0370-372X Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract The present work is a ethnomedicinal survey of the plant species of the Rosidae, Dilleniidae, Caryophyllidae and Magnoliidae subclass found in the 'Cariris Velhos'. The information collected was obtained by interviewing the 'raizeiros' and vendors of medicinal plants, and also includes a bibliographic and herbaria (JPB, EAN, IPA) survey. The voucher specimens are deposited in the JPB Herbarium. A list of the 101 plant species and their ethnomedicinal uses are presented. The subclass Rosideae is predominant with 61 species, (ca. 60%). More popular references of several species including Amburana caerensis (Fr. Allemao) A.C. Smith., Ziziphus joazeiro Mart., Bauhinia cheilanta (Bong.) Steud., Myracrodruon urundeuva Fr. Allemao and Syderoxylon obtusifolium (Roemer and Schultes) Penn. are cited. Descriptors unindexed drug, article, ethnopharmacology, medicinal plant, phytochemistry, phytotherapy Links Book Title Plantas medicinais nos Cariris Velhos, Paraiba, Parte II: Subclasses Magnoliidae, Caryophyllidae, Dilleniidae e Rosidae Database Embase Publisher Data Source Embase Authors De Fatima Agra,M., Locatelli,E., Rocha,E. A., Baracho,G. S., Formiga,S. C. Original/Translated Title URL Date of Electronic PMCID Editors
Meeting Postpartum Women's Family Planning Needs Through Integrated Family Planning and Immunization Services: Results of a Cluster-Randomized Controlled Trial in Rwanda	2016	FHI 360, Durham, NC, USA.; FHI 360, Durham, NC, USA.; FHI 360, Durham, NC, USA.; FHI 360, Durham, NC, USA.; Institute for Reproductive Health, Kigali, Rwanda.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Global health, science and practice Periodical, Abbrev. Glob.Health.Sci.Pract. Pub Date Free Form 25-Mar Volume 4 Issue 1 Start Page 73 Other Pages 86 Notes LR: 20160403; CI: (c) Dulli et al.; JID: 101624414; OID: NLM: PMC4807750; 2015/09/29 [received]; 2016/01/20 [accepted]; 2016/03 [ppublish]; 2016/02/22 [aheadofprint]; epublish Place of Publication United States ISSN/ISBN 2169-575X; 2169-575X Accession Number PMID: 27016545 Language eng SubFile Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; IM DOI 10.9745/GHSP-D-15-00291 [doi] Output Language Unknown(0) PMID 27016545 Abstract OBJECTIVE: The primary objective of this study was to test the effectiveness of integrating family planning service components into infant immunization services to increase modern contraceptive method use among postpartum women. METHODS: The study was a separate sample, parallel, cluster-randomized controlled trial. Fourteen randomly selected primary health facilities were equally allocated to intervention (integrated family planning and immunization services at the same time and location) and control groups (standard immunization services only). At baseline (May-June 2010), we interviewed postpartum women attending immunization services for their infant aged 6 to 12 months using a structured questionnaire. A separate sample of postpartum women was interviewed 16 months later after implementation of the experimental health service intervention. We used linear mixed regression models to test the study hypothesis that postpartum women attending immunization services for their infants aged 6-12 months in the intervention facilities will be more likely to use a modern contraceptive method than postpartum women attending immunization services for their infants aged 6-12 months in control group facilities. RESULTS: We interviewed and analyzed data for 825 women from the intervention group and 829 women from the control group. Results showed the intervention had a statistically significant, positive effect on modern contraceptive method use among intervention group participants compared with control group participants (regression coefficient, 0.15; 90% confidence interval [CI], 0.04 to 0.26). Although we conducted a 1-sided significance test, this effect was also significant at the 2-sided test with alpha = .05. Among those women who did not initiate a contraceptive method, awaiting the return of menses was the most common reason cited for non-use of a method. Women in both study groups overwhelmingly supported the concept of integrating family planning service components into infant immunization services (97.9% in each group), and service data collected during the intervention period did not indicate that the intervention had any negative effect on infant immunization service uptake. CONCLUSION: Integrating family planning service components into infant immunization services can be an acceptable and effective strategy to increase contraceptive use among postpartum women. Additional research is needed to examine the extent to which this integration strategy can be replicated in other health care settings. Future research should also explore persistent misconceptions regarding the relationship between return of menses and return to fertility during the postpartum period. Descriptors Links Book Title Database Publisher Data Source Authors Dulli,L.S., Eichleay,M., Rademacher,K., Sortijas,S., Nsengiyumva,T. Original/Translated Title URL Date of Electronic 20160325 PMCID PMC4807750 Editors
Menopausal age, related factors and climacteric symptoms in Libyan women	2013	Departments of Pharmacology, Faculty of Pharmacy, Tripoli University, Tripoli, Libya.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Climacteric : the journal of the International Menopause Society Periodical, Abbrev. Climacteric Pub Date Free Form Feb Volume 16 Issue 1 Start Page 179 Other Pages 184 Notes LR: 20151119; JID: 9810959; 0 (Coffee); 0 (Tea); 2012/07/04 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1473-0804; 1369-7137 Accession Number PMID: 22762366 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.3109/13697137.2012.682107 [doi] Output Language Unknown(0) PMID 22762366 Abstract OBJECTIVE: Studies of the menopause have received much attention recently as fluctuating hormone levels are known to influence a woman's mood and well-being. The present study aimed to evaluate the onset of natural menopause in Libyan women together with the prevalence of postmenopause-related symptoms experienced. METHOD: A cross-sectional survey was conducted in Tripoli city, from October 2008 to June 2009; 91 women were recruited from urban and rural areas. Data were collected using a structured questionnaire and included a number of lifestyle variables. RESULTS: The mean age of participants was 53 years, and the median age at menopause for postmenopausal women was 47 years. Out of 20 possible symptoms, the mean number of symptoms was 8.36. The most frequent symptoms were hot flushes and aching in muscles and joints (74.4%). Increasing level of education was positively associated with more symptoms, and increased tea or coffee consumption resulted in fewer symptoms. Of the total subjects, 8.1% reported no symptoms. In the four domains, 87.2% reported physical symptoms, 83.7% reported psychosocial symptoms, 76.6% reported vasomotor symptoms and 48.8% reported sexual symptoms. Our data showed that the most common disease associated with the frequency of menopausal symptoms was osteoarthritis, followed by hypertension, heart diseases and diabetes mellitus. CONCLUSION: The age of menopause in Libyan women, as in other developing countries, is less than the median age reported for Western women. The menopausal women experienced various symptoms and morbidities as part of a normal life stage, and their quality of life was negatively affected by these symptoms. Descriptors Links Book Title Database Publisher Data Source Authors Taher,Y.A., Ben Emhemed,H.M., Tawati,A.M. Original/Translated Title URL Date of Electronic 20120704 PMCID Editors
Menopausal symptoms and quality of life in Turkish women in the climacteric period	2014	Department of Fundamentals of Nursing, Ege University Faculty of Nursing , Bornova-Izmir , Turkey.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Climacteric : the journal of the International Menopause Society Periodical, Abbrev. Climacteric Pub Date Free Form Dec Volume 17 Issue 6 Start Page 705 Other Pages 712 Notes LR: 20151119; JID: 9810959; OTO: NOTNLM; 2014/08/17 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1473-0804; 1369-7137 Accession Number PMID: 24884351 Language eng SubFile Journal Article; IM DOI 10.3109/13697137.2014.929108 [doi] Output Language Unknown(0) PMID 24884351 Abstract OBJECTIVES: The purpose of this study is to determine the frequency of menopausal symptoms in Turkish women and the impact of these symptoms and related factors on the quality of life. METHODS: The sample in this cross-sectional study consisted of 1030 women, aged 40-59 years. The researcher collected the data at the women's homes via the face-to-face interview method using the Menopause-Specific Quality of Life (MENQOL) questionnaire and a questionnaire developed and drawn up in line with the literature. RESULTS: The mean age (+/- standard deviation) of the women participating in the study was 48.58 +/- 5.61 years and their mean menopausal age was 46.4 +/- 4.4 years. While the most frequently experienced menopausal symptoms in the study were feeling tired and worn out (79.2%), aches in the muscles and joints (79.1%) and low backache (77.8%), the least experienced symptom was an increase in facial hair (28.3%). Significant differences were found between the subdomain mean scores on the MENQOL according to menopausal periods (p = 0.000). Significant differences were detected in all subdomain mean scores of the MENQOL questionnaire according to age groups, perception of income, education, parity and body mass index (p Descriptors Links Book Title Database Publisher Data Source Authors Ceylan,B., Ozerdogan,N. Original/Translated Title URL Date of Electronic 20140817 PMCID Editors
Menthol cigarette and marijuana use among adolescents	2013	Department of Psychiatry, Yale University School of Medicine, New Haven, CT;	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Dec Volume 15 Issue 12 Start Page 2094 Other Pages 2099 Notes LR: 20151119; GR: P50 DA009241/DA/NIDA NIH HHS/United States; GR: P50 DA09421/DA/NIDA NIH HHS/United States; GR: R01DA026450/DA/NIDA NIH HHS/United States; JID: 9815751; 1490-04-6 (Menthol); OID: NLM: PMC3888180; 2013/07/24 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 23884319 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1093/ntr/ntt102 [doi] Output Language Unknown(0) PMID 23884319 Abstract INTRODUCTION: Menthol cigarette and marijuana use among adolescents is high; however, little is known about dual use in this age. Thus, we examined these rates among 2 samples of adolescents in Connecticut. METHODS: Study 1 examined a school-wide survey assessing variables related to cigarettes and marijuana among high school students (N = 837 [13% smokers]), and Study 2 examined these factors using baseline data of high school-aged, treatment-seeking, daily cigarette smokers prior to quitting (N = 132). RESULTS: In Study 1, lifetime marijuana use among all adolescents was 33% and past 30-day marijuana use was 21%. Among cigarette smokers, 55% reported smoking menthol cigarettes, 84% reported lifetime marijuana use, and 66% reported past 30-day marijuana use. Multivariate-adjusted logistic regression models indicated that cigarette smokers, when compared with nonsmokers, had greater rates of lifetime (odds ratio [OR] = 10.91) and past 30-day marijuana use (OR = 10.44). Among smokers, use of menthol cigarettes, when compared with use of nonmenthol cigarettes, was associated with greater lifetime (OR = 5.05) but not past 30-day marijuana use. In Study 2 with daily smokers, 59% of adolescents reported use of menthol cigarettes and 66% reported past 30-day marijuana use. Compared with nonmenthol cigarette smokers, menthol cigarette smokers were more likely to report past 30-day marijuana use (OR = 2.44). CONCLUSIONS: Cigarette smoking is associated with marijuana use, and among smokers, menthol cigarette smoking further increased the odds of marijuana use. More research on the dual use of marijuana and tobacco is needed to inform prevention and treatment of substance use. Descriptors Links Book Title Database Publisher Data Source Authors Kong,G., Singh,N., Camenga,D., Cavallo,D., Krishnan-Sarin,S. Original/Translated Title URL Date of Electronic 20130724 PMCID PMC3888180 Editors
Menthol cigarette smoking among lesbian, gay, bisexual, and transgender adults	2015	Center for Tobacco Control Research and Education, University of California, San Francisco, California. Electronic address: atfall2@uky.edu.; Institute for Pharmaceutical Outcomes and Policy, University of Kentucky, Lexington, Kentucky.; Office on Smoking	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full American Journal of Preventive Medicine Periodical, Abbrev. Am.J.Prev.Med. Pub Date Free Form Jan Volume 48 Issue 1 Start Page 93 Other Pages 97 Notes LR: 20160101; CI: Copyright (c) 2015; GR: CC999999/Intramural CDC HHS/United States; JID: 8704773; 1490-04-6 (Menthol); 6M3C89ZY6R (Nicotine); HHSPA695400; OID: NLM: HHSPA695400; OID: NLM: PMC4454462; 2014/03/03 [received]; 2014/06/20 [revised]; 2014/07/2 Place of Publication Netherlands ISSN/ISBN 1873-2607; 0749-3797 Accession Number PMID: 25245795 Language eng SubFile Journal Article; IM DOI 10.1016/j.amepre.2014.07.044 [doi] Output Language Unknown(0) PMID 25245795 Abstract BACKGROUND: Menthol can mask the harshness and taste of tobacco, making menthol cigarettes easier to use and increasing their appeal among vulnerable populations. The tobacco industry has targeted youth, women, and racial minorities with menthol cigarettes, and these groups smoke menthol cigarettes at higher rates. The tobacco industry has also targeted the lesbian, gay, bisexual, and transgender (LGBT) communities with tobacco product marketing. PURPOSE: To assess current menthol cigarette smoking by sexual orientation among a nationally representative sample of U.S. adults. METHODS: Data were obtained from the 2009-2010 National Adult Tobacco Survey, a national landline and cellular telephone survey of non-institutionalized U.S. adults aged >/=18 years, to compare current menthol cigarette smoking between LGBT (n=2,431) and heterosexual/straight (n=110,841) adults. Data were analyzed during January-April 2014 using descriptive statistics and logistic regression adjusted for sex, age, race, and educational attainment. RESULTS: Among all current cigarette smokers, 29.6% reported usually smoking menthol cigarettes in the past 30 days. Menthol use was significantly higher among LGBT smokers, with 36.3% reporting that the cigarettes they usually smoked were menthol compared to 29.3% of heterosexual/straight smokers (p Descriptors Links Book Title Database Publisher American Journal of Preventive Medicine Data Source Authors Fallin,A., Goodin,A.J., King,B.A. Original/Translated Title URL Date of Electronic 20140919 PMCID PMC4454462 Editors
Menthol cigarettes and indicators of tobacco dependence among adolescents	2007	University of Medicine and Dentistry of New Jersey, School of Public Health, 317 George Street, Suite 209, New Brunswick, New Jersey 08901, USA. olivia.wackowski@umdnj.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Addictive Behaviors Periodical, Abbrev. Addict.Behav. Pub Date Free Form Sep Volume 32 Issue 9 Start Page 1964 Other Pages 1969 Notes LR: 20151119; JID: 7603486; 1490-04-6 (Menthol); 2006/07/19 [received]; 2006/11/17 [revised]; 2006/12/14 [accepted]; 2006/12/22 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 0306-4603; 0306-4603 Accession Number PMID: 17229528 Language eng SubFile Journal Article; IM DOI S0306-4603(06)00403-5 [pii] Output Language Unknown(0) PMID 17229528 Abstract OBJECTIVES: This study examines measures of nicotine dependence among adolescent menthol and non-menthol cigarette smokers in a nationally representative sample. METHODS: We examined rates of menthol smoking and measures of nicotine dependence among 1345 current established smokers in grades 9-12 who participated in the 2004 National Youth Tobacco Survey. Logistic regression was used to generate an adjusted odds ratio (OR) for menthol smoking for four measures of nicotine dependence, controlling for demographic characteristics and smoking patterns. RESULTS: Approximately 46% of all current established cigarette smokers were menthol smokers. Menthol smokers had 2.6 and 1.6 greater odds than non-menthol smokers for reporting that they could go for less than 1 h before feeling like they need a cigarette and that they experience cravings after not smoking for a while, respectively. CONCLUSIONS: Menthol cigarette smoking was associated with two dependence measures and may be more addictive than regular cigarettes in young smokers. Future research should continue to explore relationships between dependency and menthol use as well as the high prevalence of menthol use among adolescents. Descriptors Adolescent, Age Factors, Female, Humans, Male, Menthol, Prevalence, Severity of Illness Index, Surveys and Questionnaires, Tobacco Use Disorder/epidemiology Links Book Title Database Publisher Data Source Authors Wackowski,O., Delnevo,C. D. Original/Translated Title URL Date of Electronic 20061222 PMCID Editors
Menthol cigarettes, race/ethnicity, and biomarkers of tobacco use in U.S. adults: the 1999-2010 National Health and Nutrition Examination Survey (NHANES)	2013	Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. mijones@jhsph.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Periodical, Abbrev. Cancer Epidemiol.Biomarkers Prev. Pub Date Free Form Feb Volume 22 Issue 2 Start Page 224 Other Pages 232 Notes LR: 20151119; GR: R03 CA153959/CA/NCI NIH HHS/United States; GR: R03CA153959/CA/NCI NIH HHS/United States; GR: T32 HL007024/HL/NHLBI NIH HHS/United States; GR: T32HL007024/HL/NHLBI NIH HHS/United States; JID: 9200608; 0 (4-(methylnitrosamino)-1-(3-pyridyl Place of Publication United States ISSN/ISBN 1538-7755; 1055-9965 Accession Number PMID: 23250935 Language eng SubFile Comparative Study; Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1158/1055-9965.EPI-12-0912 [doi] Output Language Unknown(0) PMID 23250935 Abstract BACKGROUND: In the United States, cigarette flavorings are banned, with the exception of menthol. The cooling effects of menthol could facilitate the absorption of tobacco toxicants. We examined levels of biomarkers of tobacco exposure among U.S. smokers of menthol and nonmenthol cigarettes. METHODS: We studied 4,603 White, African-American, and Mexican-American current smokers 20 years of age or older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2010 and had data on cigarette type and serum cotinine, blood cadmium, and blood lead concentrations. Urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) (NNAL) was studied in 1,607 participants with available measures. RESULTS: A total of 3,210 (74.3%) participants smoked nonmenthol cigarettes compared with 1,393 (25.7%) participants who smoked menthol cigarettes. The geometric mean concentrations comparing smokers of nonmenthol with menthol cigarettes were 163.1 versus 175.9 ng/mL for serum cotinine; 0.95 versus 1.02 mug/L for blood cadmium; 1.87 versus 1.75 mug/dL for blood lead; and 0.27 versus 0.23 ng/mL for urine NNAL. After multivariable adjustment, the ratios [95% confidence interval (CI)] comparing smokers of menthol with nonmenthol cigarettes were 1.03 (0.95-1.11) for cotinine, 1.10 (1.04-1.16) for cadmium, 0.95 (0.90-1.01) for lead, and 0.81 (0.65-1.01) for NNAL. CONCLUSIONS: In a representative sample of U.S. adult smokers, current menthol cigarette use was associated with increased concentration of blood cadmium, an established carcinogen and highly toxic metal, but not with other biomarkers. IMPACT: These findings provide information regarding possible differences in exposure to toxic constituents among menthol cigarette smokers compared with nonmenthol cigarette smokers. Descriptors Links Book Title Database Publisher Data Source Authors Jones,M.R., Apelberg,B.J., Tellez-Plaza,M., Samet,J.M., Navas-Acien,A. Original/Translated Title URL Date of Electronic 20121218 PMCID PMC3565051 Editors
Merkel Cell Carcinoma: rising incidence in the East of England	2016	Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.; National Cancer Registration Service, Public Health England, Cambridge, UK.; Department of Pathology, Norfolk and Norwich University Hospital, Norwich, UK.; Department of De	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of the European Academy of Dermatology and Venereology : JEADV Periodical, Abbrev. J.Eur.Acad.Dermatol.Venereol. Pub Date Free Form 12-Aug Volume Issue Start Page Other Pages Notes LR: 20160812; CI: (c) 2016; JID: 9216037; 2016/03/31 [received]; 2016/05/19 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1468-3083; 0926-9959 Accession Number PMID: 27515234 Language ENG SubFile JOURNAL ARTICLE DOI 10.1111/jdv.13828 [doi] Output Language Unknown(0) PMID 27515234 Abstract BACKGROUND: Merkel Cell Carcinoma (MCC) is an infrequent but highly aggressive skin cancer. Five-year survival rates are poor, as there are high rates of metastases at primary diagnoses. Recurrences are also common. There is controversy about actual incidence rates which vary considerably between developed countries with majority populations of fair skin types. OBJECTIVES: We report the age-standardized incidence rates of MCC for both males and females from the East of England, and use linear regression analyses to estimate numbers of cases for 2020 and 2025 to aid healthcare planning and allocation of resources. METHODS: All cases of MCC diagnosed histopathologically between 1st January 2004 and 31st December 2013 were extracted from the databases of the Eastern Office, National Cancer Registration Service, Public Health England, and the Pathology department of the Norfolk and Norwich University Hospital, which serves as the tertiary referral centre for the region. Age-standardization incidence rate calculations (ASIs) and linear regression analyses were performed. RESULTS: The ASIs for males and females were 0.70 and 1.08 per 100 000 person-years respectively. The total age-adjusted incidence rate was therefore 1.78 per 100 000 person-years. The ratio of female: male disease was 3:2. The total number of cases for this region over the time period studied was 73. There has been a threefold increase over this period. Estimated cases for this region are 17 in 2020, and 22 in 2025. Estimated UK cases for 2020 are 920, and 1134 in 2025. CONCLUSIONS: MCC is increasing steadily in the East of England, and has risen threefold over the last 10 years and is similar to the highest reported rates from Western Australia. These data are 12-fold higher than previous UK estimates, and suggest that the incidence rate is also rising in other regions of the UK. Descriptors Links Book Title Database Publisher European Academy of Dermatology and Venereology Data Source Authors Goon,P.K., Greenberg,D.C., Igali,L., Levell,N.J. Original/Translated Title URL Date of Electronic 20160812 PMCID Editors

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