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Diethyl 2,6-dihy-droxy-4-(3-nitro-phen-yl)-2,6-bis-(trifluoro-meth-yl)piperidine-3,5-dica rboxyl-ate 2012
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Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
1-Feb
Volume
68
Issue
Pt 2
Start Page
o400
Other Pages
1
Notes
JID: 101089178; OID: NLM: PMC3275076; 2011/12/16 [received]; 2011/12/23 [accepted]; 2012/01/14 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 22347021
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536811055346 [doi]
Output Language
Unknown(0)
PMID
22347021
Abstract
In the title compound, C(19)H(20)F(6)N(2)O(8), the eth-oxy and ethyl groups are disordered over two sets of sites, with occupancy ratios of 0.212 (18):0.788 (18) and 0.746 (6):0.254 (6), respectively. The piperidine ring adopts a chair conformation. In the mol-ecule, intra-molecular O-Hcdots, three dots, centeredO hydrogen bonds form two S(6) ring motifs. In the crystal, mol-ecules are linked via O-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds, forming dimers.
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Database
Publisher
Data Source
Authors
Fun,H.K., Arshad,S., Reddy,B.P., Vijayakumar,V., Sarveswari,S.
Original/Translated Title
URL
Date of Electronic
20120114
PMCID
PMC3275076
Editors
2-(8-Bromo-imidazo[1,2-a]pyridin-2-yl)-N'-[(E)-4-diethyl-amino-2-hy-droxy-benzyl- idene]acetohydrazide dihydrate 2012
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Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
1-Mar
Volume
68
Issue
Pt 3
Start Page
o816
Other Pages
7
Notes
JID: 101089178; OID: NLM: PMC3297878; 2012/02/15 [received]; 2012/02/15 [accepted]; 2012/02/24 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 22412681
Language
eng
SubFile
Journal Article
DOI
10.1107/S160053681200685X [doi]
Output Language
Unknown(0)
PMID
22412681
Abstract
In the title compound, C(20)H(22)BrN(5)O(2).2H(2)O, the Schiff base mol-ecule exists in an E conformation with respect to the acyclic C=N bond. An S(6) ring motif is formed via an intra-molecular O-Hcdots, three dots, centeredN hydrogen bond. The dihedral angle between the imidazo[1,2-a]pyridine system and the benzene ring is 84.62 (5) degrees . In the crystal, N-Hcdots, three dots, centeredO, O-Hcdots, three dots, centeredO, O-Hcdots, three dots, centeredN, C-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredBr hydrogen bonds link the mol-ecules into a three-dimensional network. The crystal packing is further stabilized by C-Hcdots, three dots, centeredpi and pi-pi inter-actions [centroid-centroid distance = 3.5365 (7) A].
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Book Title
Database
Publisher
Data Source
Authors
Fun,H.K., Loh,W.S., Shenvi,S., Isloor,A.M., Hegde,G.
Original/Translated Title
URL
Date of Electronic
20120224
PMCID
PMC3297878
Editors
N-(2-{[5-Bromo-2-(morpholin-4-yl)pyrimidin-4-yl]sulfan-yl}-4-meth-oxy-phen-yl)-4- methyl-benzene-sulfonamide 2012
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Print(0)
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Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
1-Aug
Volume
68
Issue
Pt 8
Start Page
o2590
Other Pages
1
Notes
LR: 20130304; JID: 101089178; OID: NLM: PMC3415028; 2012/07/19 [received]; 2012/07/24 [accepted]; 2012/07/28 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 22905015
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536812033375 [doi]
Output Language
Unknown(0)
PMID
22905015
Abstract
In the title compound, C(22)H(23)BrN(4)O(4)S(2), the benzene rings bridged by the sulfonamide group are tilted relative to each other by 68.9 (1) degrees and the dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 69.7 (1) degrees . The mol-ecular conformation is stabilized by a weak intra-molecular pi-pi stacking inter-action between the pyrimidine and the 4-methylbenzene rings [centroid-centroid distance = 3.934 (2) A]. The morpholine ring adopts a chair conformation and is disordered over two positions with an occupancy ratio of 0.853 (6):0.147 (6). In the crystal, mol-ecules are linked by N-Hcdots, three dots, centeredO hydrogen bonds into chains extending along the a axis and further, through C-Hcdots, three dots, centeredN and C-Hcdots, three dots, centeredO inter-actions, into a three-dimensional supramolecular structure.
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Database
Publisher
Data Source
Authors
Kant,R., Gupta,V.K., Kapoor,K., Kumar,M., Mallesha,L., Sridhar,M.A.
Original/Translated Title
URL
Date of Electronic
20120728
PMCID
PMC3415028
Editors
3-[4-(3,4-Dimethyl-5,5-dioxo-2H,4H-pyrazolo-[4,3-c][1,2]benzothia-zin-2-yl)phen-y l]-2-hy-droxy-1-mesitylprop-2-en-1-one hexane hemisolvate 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
1-Feb
Volume
68
Issue
Pt 2
Start Page
o460
Other Pages
1
Notes
LR: 20130227; JID: 101089178; OID: NLM: PMC3275214; 2011/12/02 [received]; 2012/01/07 [accepted]; 2012/01/18 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 22347070
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536812000712 [doi]
Output Language
Unknown(0)
PMID
22347070
Abstract
In the title compound, C(29)H(27)N(3)O(4)S.0.5C(6)H(14), the heterocyclic thia-zine ring adopts a half-chair conformation with the S and N atoms displaced by 0.500 (5) and 0.229 (5) A, respectively, on opposite sides from the mean plane formed by the remaining ring atoms. The mean planes of the pyrazole ring and the benzene ring bonded to it form a dihedral angle of 35.76 (11) degrees and an intra-molecular O-Hcdots, three dots, centeredO hydrogen bond ocurs. The crystal structure features O-Hcdots, three dots, centeredO and C-Hcdots, three dots, centeredO hydrogen bonds. There is a half-mol-ecule of hexane in the asymmetric unit lying about an inversion center. It is disordered over two sets of sites with occupancy factors 0.590 (9) and 0.410 (9).
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Database
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Data Source
Authors
Bukhari,M.H., Ahmad,M., Siddiqui,H.L., Gul,S., Parvez,M.
Original/Translated Title
URL
Date of Electronic
20120118
PMCID
PMC3275214
Editors
N-[4-(4-Bromo-phen-yl)thia-zol-2-yl]-4-(piperidin-1-yl)butanamide 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Acta crystallographica.Section E, Structure reports online
Periodical, Abbrev.
Acta Crystallogr.Sect.E.Struct.Rep.Online
Pub Date Free Form
1-Jun
Volume
68
Issue
Pt 6
Start Page
o1665
Other Pages
Notes
JID: 101089178; OID: NLM: PMC3379262; 2012/04/28 [received]; 2012/04/29 [accepted]; 2012/05/12 [epublish]; ppublish
Place of Publication
United States
ISSN/ISBN
1600-5368; 1600-5368
Accession Number
PMID: 22719460
Language
eng
SubFile
Journal Article
DOI
10.1107/S1600536812019204 [doi]
Output Language
Unknown(0)
PMID
22719460
Abstract
In the title compound, C(18)H(22)BrN(3)OS, the piperidine ring adopts a chair conformation. The mean plane of the thia-zole ring forms dihedral angles of 23.97 (10) and 75.82 (10) degrees with the mean planes of its adjacent benzene and piperidine rings, respectively. An intra-molecular N-Hcdots, three dots, centeredN hydrogen bond generates an S(7) ring motif in the mol-ecule. In the crystal, no significant inter-moelcular hydrogen bonds are observed, but a weak pi-pi inter-action with a centroid-centroid distance of 3.8855 (13) A occurs.
Descriptors
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Book Title
Database
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Data Source
Authors
Ghabbour,H.A., Kadi,A.A., El-Subbagh,H.I., Chia,T.S., Fun,H.K.
Original/Translated Title
URL
Date of Electronic
20120512
PMCID
PMC3379262
Editors
Hookah smoking, nass chewing, and oesophageal squamous cell carcinoma in Kashmir, India 2012
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Print(0)
Ref Type
Journal Article
Periodical, Full
Br J Cancer
Periodical, Abbrev.
Br.J.Cancer
Pub Date Free Form
Volume
107
Issue
9
Start Page
1618
Other Pages
23
Notes
ID: 23033008
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
BACKGROUND: Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case-control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ESCC are common, to investigate the association of hookah smoking, nass use, and several other habits with ESCC. METHODS: We recruited 702 histologically confirmed ESCC cases and 1663 hospital-based controls, individually matched to the cases for age, sex, and district of residence from September 2008 to January 2012. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Ever-hookah smoking (OR=1.85; 95% CI, 1.41-2.44) and nass chewing (OR=2.88; 95% CI, 2.06-4.04) were associated with ESCC risk. These associations were consistent across different measures of use, including intensity, duration, and cumulative amount of use, and after excluding ever users of the other product and cigarette smokers. Our results also suggest an increased risk of ESCC associated with ever-gutka chewing and -bidi smoking. However, the latter associations were based on small number of participants. CONCLUSION: This study shows that hookah and nass use are associated with ESCC risk. As prevalence of hookah use seems to be increasing among young people worldwide, these results may have relevance not only for the regions in which hookah use has been a traditional habit, but also for other regions, including western countries.
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Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Dar,N A., Bhat,G A., Shah,I A., Iqbal,B., Makhdoomi,M A., Kakhdoomi,M A., Nisar,I., Rafiq,R., Iqbal,S T., Bhat,A B., Nabi,S., Shah,S A., Shafi,R., Masood,A., Lone,M M., Zargar,S A., Najar,M S., Islami,F., Boffetta,P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
The detrimental danger of Water-Pipe (Hookah) transcends the hazardous consequences of general health to the driving behavior 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
J Transl Med
Periodical, Abbrev.
Pub Date Free Form
Volume
10
Issue
Start Page
126
Other Pages
126
Notes
ID: 22709610
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
OBJECTIVE: To determine whether the consumption of tobacco used in Water-Pipe by drivers increases the risk of a motor vehicle collision as a consequence of hypoxia. DESIGN: Analytical case-control study. DATA SOURCES: Seventy exclusive Water-Pipe smokers (Experimental Group--EG)--mean age ± SD: 29.47 ± 10.45 years; mean number of weekly WPS, (6.9 ± 3.7); mean duration of WPS (WPS) is (7.5 ± 2.1 years)--and thirty non-smoker (Control Group--CG; mean age ± SD: 36.33 ± 13.92 years) were recruited during 2011 from two Arab villages located in the Galilee, northern Israel. METHODS: We performed a case-control study exclusively among Water-Pipe smokers with an appropriate non smokers control group. Demographic questionnaire, Pulse Oxymeter for blood oxygenation measure and a driver simulator for measuring various participants driving behaviors were utilized. Statistical analysis for analyzing the different variables, Pearson's x2 analysis for the comparison of categorical variables, continuous variable is compared using Student's t-test and for testing the correlation between the different variables and bivariate correlation analysis were applied. RESULTS: In the (EG) following WPS, we observed increase in the pulse rate--from 80 to 95 (t = 11.84, p
Descriptors
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Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Elias,Wafa, Assy,Nimer, Elias,Ibrahim, Toledo,Tomer, Yassin,Mustafa, Bowirrat,Abdalla
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
US health policy related to hookah tobacco smoking 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Am J Public Health
Periodical, Abbrev.
Am.J.Public Health
Pub Date Free Form
Volume
102
Issue
9
Start Page
e47
Other Pages
51
Notes
ID: 22827447
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
OBJECTIVES: Although US cigarette smoking is decreasing, hookah tobacco smoking (HTS) is an emerging trend associated with substantial toxicant exposure. We assessed how a representative sample of US tobacco control policies may apply to HTS. METHODS: We examined municipal, county, and state legal texts applying to the 100 largest US cities. We developed a summary policy variable that distinguished among cities on the basis of how current tobacco control policies may apply to HTS and used multinomial logistic regression to determine associations between community-level sociodemographic variables and the policy outcome variable. RESULTS: Although 73 of the 100 largest US cities have laws that disallow cigarette smoking in bars, 69 of these cities have exemptions that allow HTS; 4 of the 69 have passed legislation specifically exempting HTS, and 65 may permit HTS via generic tobacco retail establishment exemptions. Cities in which HTS may be exempted had denser populations than cities without clean air legislation. CONCLUSIONS: Although three fourths of the largest US cities disallow cigarette smoking in bars, nearly 90% of these cities may permit HTS via exemptions. Closing this gap in clean air regulation may significantly reduce exposure to HTS.
Descriptors
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482044/?tool=pubmed
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Primack,Brian A., Hopkins,Maggie, Hallett,Cynthia, Carroll,Mary V., Zeller,Mitchell, Dachille,Kathleen, Kim,Kevin H., Fine,Michael J., Donohue,Julie M.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Dependence on tobacco and nicotine products: a case for product-specific assessment 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine Tob Res
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Volume
14
Issue
11
Start Page
1382
Other Pages
90
Notes
ID: 22459798
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
The International Classification of Diseases and the Diagnostic and Statistical Manual for diagnosing tobacco/nicotine dependence emphasize the dependence-producing drug nicotine. These diagnostic tools have been challenged on grounds of poor predictive validity, and they do not differentiate across various forms of nicotine-containing products. In fact, nicotine-containing products (e.g., tobacco cigarettes, smokeless tobacco ST], waterpipe, electronic cigarettes ECIGs], and nicotine replacement NR] products) have very different characteristics both in terms of sensory and behavioral involvement and also in pharmacokinetic and pharmacodynamic effects. For example, a cigarette and a nicotine patch are very different on almost every one of these dimensions. When ability to stop using a nicotine/tobacco product is used as a criterion for dependence, success rates vary considerably across products: Tobacco cigarette cessation is more difficult than ST cessation that in turn is more difficult than NR product cessation. Based on these results, we hypothesize that there is a continuum of dependence as much as there is a continuum of harm, with tobacco cigarettes and NR products on opposite ends of both continua and other products (waterpipe and ECIGs) somewhere in between. In order to capture more precisely the dependence produced by both nicotine and its administration forms, product-specific instruments may be required. The pros and cons of this approach are discussed.
Descriptors
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Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Fagerström, Karl, Eissenberg,Thomas
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Bladder cancer, a review of the environmental risk factors 2012
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Environ Health
Periodical, Abbrev.
Environ.Health
Pub Date Free Form
Volume
11 Suppl 1
Issue
Start Page
S11
Other Pages
S11
Notes
ID: 22759493
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
BACKGROUND: Many epidemiological studies and reviews have been performed to identify the causes of bladder cancer. The aim of this review is to investigate the links between various environmental risk factors and cancer of the bladder. METHODS: A systematic literature search was performed using PubMed, Science Direct, Scopus, Scholar Google and Russian Google databases to identify reviews and epidemiological studies on bladder cancer risk factors associated with the environment published between 1998 and 2010. Only literature discussing human studies was considered. RESULTS: Smoking, mainly cigarette smoking, is a well known risk factor for various diseases, including bladder cancer. Another factor strongly associated with bladder cancer is exposure to arsenic in drinking water at concentrations higher than 300 µg/l. The most notable risk factor for development of bladder cancer is occupational exposure to aromatic amines (2-naphthylamine, 4-aminobiphenyl and benzidine) and 4,4'-methylenebis(2-chloroaniline), which can be found in the products of the chemical, dye and rubber industries as well as in hair dyes, paints, fungicides, cigarette smoke, plastics, metals and motor vehicle exhaust. There are also data suggesting an effect from of other types of smoking besides cigarettes (cigar, pipe, Egyptian waterpipe, smokeless tobacco and environmental tobacco smoking), and other sources of arsenic exposure such as air, food, occupational hazards, and tobacco. Other studies show that hairdressers and barbers with occupational exposure to hair dyes experience enhanced risk of bladder cancer. For example, a study related to personal use of hair dyes demonstrates an elevated bladder cancer risk for people who used permanent hair dyes at least once a month, for one year or longer. CONCLUSION: Smoking, in particular from cigarettes, exposure to arsenic in drinking water, and occupational exposure to aromatic amines and 4,4'-methylenebis(2-chloroaniline) are well known risk factors for various diseases including bladder cancer. Although the number of chemicals related to occupational exposure is still growing, it is worth noting that it may take several years or decades between exposure and the subsequent cancer.
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Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Letasiová, Silvia, Medve'ová, Alzbeta, Sovcíková, Andrea, Dusinská, Mária, Volkovová, Katarína, Mosoiu,Claudia, Bartonová, Alena
Original/Translated Title
URL
Date of Electronic
PMCID
Editors