WTS database

Title	Pub Year	Author	SearchLink Sort descending
Determinants of hookah use among high school students	2011	Department of Family and Preventive Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. waldelaimy@ucsd.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Jul Volume 13 Issue 7 Start Page 565 Other Pages 572 Notes LR: 20151119; JID: 9815751; 2011/03/31 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 21454909 Language eng SubFile Comparative Study; Journal Article; IM DOI 10.1093/ntr/ntr041 [doi] Output Language Unknown(0) PMID 21454909 Abstract INTRODUCTION: Hookah use is increasing among young people, but there are limited data on its use among high school-age populations. We examined hookah use initiation, prevalence, cessation, and psychosocial risk factors of hookah use among high school students. METHODS: A cross-sectional survey of 689 students from three high schools in San Diego County was used to compare characteristics of hookah ever-users to nonusers and factors associated with current and former hookah use. RESULTS: Hookah ever-use in the study population was 26.1%, previous month hookah use was 10.9%, and current hookah use was 10.3%. Most students first learned about hookah from friends (50.3%) or saw a hookah lounge (20.9%). Students believed hookah to be more socially acceptable than cigarettes and less harmful than cigarettes, cigars, and smokeless tobacco. Hookah ever-users were significantly more likely than nonusers to have smoked cigarettes, to know of a hookah lounge in their community, and to believe hookah is safer and more socially acceptable than cigarettes. In comparison to former users, current users were more likely to have recently smoked a cigarette, to know of a hookah lounge in their community, and to believe hookah is more socially acceptable than cigarettes. CONCLUSIONS: Hookah use is becoming a commonly acceptable behavior among adolescents, and risk perception is a significant factor. Presence of hookah lounges are associated with increased hookah use among high school students and should be a target of further regulation. Descriptors Links Book Title Database Publisher Data Source Authors Smith,J.R., Novotny,T.E., Edland,S.D., Hofstetter,C.R., Lindsay,S.P., Al-Delaimy,W.K. Original/Translated Title URL Date of Electronic 20110331 PMCID Editors
Nicotine dependence among Chinese city dwellers: a population-based cross-sectional study	2011	Center for Tobacco Control Research, Zhejiang University School of Medicine, Yuhangtang Road, Hangzhou, Zhejiang, China. ytingzhongyang@yahoo.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Jul Volume 13 Issue 7 Start Page 556 Other Pages 564 Notes LR: 20151119; JID: 9815751; 2011/03/31 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 21454911 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1093/ntr/ntr040 [doi] Output Language Unknown(0) PMID 21454911 Abstract INTRODUCTION: Although nicotine addiction is thought to be the primary driver of tobacco smoking, few studies have examined nicotine dependence among Chinese mainland smokers. METHODS: A population-based cross-sectional study was designed. Subjects (4735) aged 15 years and older residents were drawn from six cities in China through a multistage systematic sampling procedure. Nicotine dependence of respondents was assessed in a face-to-face interview using the 6-item Mandarin Chinese version of the Fagerstrom Test for Nicotine Dependence (FTND). A multilevel regression model, accounting for cluster sampling, was used to identify correlates of dependence. RESULTS: Among females, only 4.2% (n = 115) were smokers (2.5% daily, 1.7% occasional). Subsequent analysis focused on males, of whom 50.8% (n = 1477) were smokers (38.9% daily, 11.9% occasional). The average FTND score was 2.89 (95% CI: 2.77-3.01) among all current smokers. Daily smokers had a significantly higher FTND score (3.49, 95% CI: 3.35-3.63) than occasional smokers (1.12, 95% CI: 0.98-1.26) (p /= 4. Among daily smokers, FTND scores were negatively associated with age at smoking initiation, education, and self-efficacy for quitting smoking. FTND was associated (negatively) with income among occasional smokers only. There were regional differences in FTND scores among daily smokers. CONCLUSIONS: Cigarette smoking is highly prevalent among Chinese males but rare among Chinese females. Occasional smoking is also common among males. Only 3.3% of occasional male smokers appear dependent by FTND criteria. Dependence varies by smoking history and demographics. These findings have implications for design and implementation of smoking cessation interventions. Descriptors Links Book Title Database Publisher Data Source Authors Yang,T., Shiffman,S., Rockett,I.R., Cui,X., Cao,R. Original/Translated Title URL Date of Electronic 20110331 PMCID Editors
Flavored waters: influence of ingredients on antioxidant capacity and terpenoid profile by HS-SPME/GC-MS	2011	Requimte/Faculdade de Farmacia, Universidade do Porto, Porto, Portugal.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of Agricultural and Food Chemistry Periodical, Abbrev. J.Agric.Food Chem. Pub Date Free Form 11-May Volume 59 Issue 9 Start Page 5062 Other Pages 5072 Notes LR: 20131121; JID: 0374755; 0 (Antioxidants); 0 (Flavoring Agents); 0 (Terpenes); 059QF0KO0R (Water); 2011/04/04 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1520-5118; 0021-8561 Accession Number PMID: 21462928 Language eng SubFile Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1021/jf1048244 [doi] Output Language Unknown(0) PMID 21462928 Abstract The antioxidant profiles of 39 water samples (29 flavored waters based on 10 natural waters) and 6 flavors used in their formulation (furnished by producers) were determined. Total phenol and flavonoid contents, reducing power, and DPPH radical scavenging activity were the optical techniques implemented and included in the referred profile. Flavor extracts were analyzed by HS-SPME/GC-MS to obtain the qualitative and quantitative profiles of the volatile fraction of essential oils. Results pointed out a higher reducing power (0.14-11.8 mg of gallic acid/L) and radical scavenging activity (0.29-211.5 mg Trolox/L) of flavored waters compared with the corresponding natural ones, an interesting fact concerning human health. Bioactive compounds, such as polyphenols, were present in all samples (0.5-359 mg of gallic acid/L), whereas flavonoids were not present either in flavored waters or in flavors. The major components of flavor extracts were monoterpenes, such as citral, alpha-limonene, carveol, and alpha-terpineol. Descriptors Links Book Title Database Publisher Data Source Authors Barroso,M.F., Noronha,J.P., Delerue-Matos,C., Oliveira,M.B. Original/Translated Title URL Date of Electronic 20110404 PMCID Editors
Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains	2011	Department of Medical Microbiology, University Medical Centre Utrecht, the Netherlands. m.leversteinvhall@umcutrecht.nl	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Periodical, Abbrev. Clin.Microbiol.Infect. Pub Date Free Form Jun Volume 17 Issue 6 Start Page 873 Other Pages 880 Notes CI: 2011 The Authors. Clinical Microbiology and Infection; 2011; JID: 9516420; EC 3.5.2.6 (beta-Lactamases); 2011/04/04 [aheadofprint]; ppublish Place of Publication France ISSN/ISBN 1469-0691; 1198-743X Accession Number PMID: 21463397 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1111/j.1469-0691.2011.03497.x [doi] Output Language Unknown(0) PMID 21463397 Abstract Intestinal carriage of extended-spectrum beta-lactamase (ESBL) -producing bacteria in food-producing animals and contamination of retail meat may contribute to increased incidences of infections with ESBL-producing bacteria in humans. Therefore, distribution of ESBL genes, plasmids and strain genotypes in Escherichia coli obtained from poultry and retail chicken meat in the Netherlands was determined and defined as 'poultry-associated' (PA). Subsequently, the proportion of E. coli isolates with PA ESBL genes, plasmids and strains was quantified in a representative sample of clinical isolates. The E. coli were derived from 98 retail chicken meat samples, a prevalence survey among poultry, and 516 human clinical samples from 31 laboratories collected during a 3-month period in 2009. Isolates were analysed using an ESBL-specific microarray, sequencing of ESBL genes, PCR-based replicon typing of plasmids, plasmid multi-locus sequence typing (pMLST) and strain genotyping (MLST). Six ESBL genes were defined as PA (bla(CTX-M-1) , bla(CTX-M-2) , bla(SHV-2) , bla(SHV-12) , bla(TEM-20) , bla(TEM-52) ): 35% of the human isolates contained PA ESBL genes and 19% contained PA ESBL genes located on IncI1 plasmids that were genetically indistinguishable from those obtained from poultry (meat). Of these ESBL genes, 86% were bla(CTX-M-1) and bla(TEM-52) genes, which were also the predominant genes in poultry (78%) and retail chicken meat (75%). Of the retail meat samples, 94% contained ESBL-producing isolates of which 39% belonged to E. coli genotypes also present in human samples. These findings are suggestive for transmission of ESBL genes, plasmids and E. coli isolates from poultry to humans, most likely through the food chain. Descriptors Links Book Title Database Publisher European Society of Clinical Microbiology and Infectious Diseases Data Source Authors Leverstein-van Hall,M.A., Dierikx,C.M., Cohen Stuart,J., Voets,G.M., van den Munckhof,M.P., van Essen-Zandbergen,A., Platteel,T., Fluit,A.C., van de Sande-Bruinsma,N., Scharinga,J., Bonten,M.J., Mevius,D.J., National ESBL surveillance group Original/Translated Title URL Date of Electronic 20110404 PMCID Editors
Affecting perceptions of harm and addiction among college waterpipe tobacco smokers	2011	Duke University School of Nursing, 307 Trent Dr., Durham, NC 27710, USA. Isaac.Lipkus@Duke.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Jul Volume 13 Issue 7 Start Page 599 Other Pages 610 Notes LR: 20160527; GR: P30 DA023026/DA/NIDA NIH HHS/United States; GR: P30 DA023026/DA/NIDA NIH HHS/United States; GR: R01 CA114389/CA/NCI NIH HHS/United States; JID: 9815751; OID: NLM: PMC3129239; 2011/04/06 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 21471304 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; IM DOI 10.1093/ntr/ntr049 [doi] Output Language Unknown(0) PMID 21471304 Abstract INTRODUCTION: The spread of waterpipe tobacco use among youth may be due in part to perceptions that waterpipe tobacco use is safer than other tobacco products, such as cigarettes. In two pilot studies, we sought to modify college waterpipe smokers' perceived risks and worry about waterpipe tobacco smoking. METHODS: We conducted two web-based studies that varied whether college waterpipe users received information on (a) spread of and use of flavored tobacco in waterpipe and (b) harms of waterpipe smoking. Study 1 (N = 91) tested the "incremental" effects on perceptions of risk and worry of adding information about harms of waterpipe smoking to information on the spread of waterpipe and use of flavorings in the tobacco. Study 2 (N = 112) tested the effects on perceptions of risk and worry of reviewing information about harms of waterpipe smoking compared to a no information control group. In Study 1 only, we assessed as part of a 6-month follow-up (n = 70) the percentage of participants who reported no longer using waterpipe. RESULTS: Pooling data from both studies, participants who received information about the harms of waterpipe smoking reported greater perceived risk and worry about harm and addiction and expressed a stronger desire to quit. In Study 1, 62% of participants in the experimental group versus 33% in the control group reported having stopped waterpipe use. CONCLUSIONS: These are the first studies to show that perceptions of addiction and harm from waterpipe use can be modified using minimally intensive interventions; such interventions show promise at decreasing waterpipe use. Descriptors Links Book Title Database Publisher Data Source Authors Lipkus,I.M., Eissenberg,T., Schwartz-Bloom,R.D., Prokhorov,A.V., Levy,J. Original/Translated Title URL Date of Electronic 20110406 PMCID PMC3129239 Editors
Increasing prevalence of smoke-free homes and decreasing rates of sudden infant death syndrome in the United States: an ecological association study	2012	Center for Global Tobacco Control, Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, USA. ibehm@hsph.harvard.edu.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Jan Volume 21 Issue 1 Start Page 6 Other Pages 11 Notes JID: 9209612; 0 (Tobacco Smoke Pollution); 2011/04/07 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 21474502 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1136/tc.2010.041376 [doi] Output Language Unknown(0) PMID 21474502 Abstract PURPOSE: This study utilises an ecological design to analyse the relation between concurrent temporal trends in sudden infant death syndrome (SIDS) rates and prevalence of smoke-free households with infants in the USA, controlling for an important risk factor, infant supine sleep position. METHODS: Annual state-specific SIDS cases were computed using period linked birth/infant death files; the prevalence of 100% smoke-free homes with infants using Tobacco Use Supplement to the Current Population Survey data, and percentage of infants in supine sleep position from National Infant Sleep Position data, for years 1995-2006. Incidence rate ratios relating trends in SIDS cases and risk factors were determined using time-series negative binomial regression. Population-level health effects were assessed with secondhand smoke (SHS) exposure population attributable fractions and excess attributable SIDS deaths. RESULTS: For every 1% absolute increase in the prevalence of smoke-free homes with infants, SIDS rates decreased 0.4% from 1995 to 2006, controlling for supine sleep position. Nationally, it is possible that 20% of the 1326 total SIDS cases were attributable to childhood SHS exposure at home in 2006 with potentially 534 fewer infant deaths attributable to SHS exposure in 2006 than in 1995, owing to an increasing prevalence of 100% smoke-free homes with infants. Cumulatively, 4402 (lower 95% CI) to 6406 (upper 95% CI) excess SIDS cases may have been attributable to SHS exposure in the home over the 12-year study period. CONCLUSIONS: The uptake of voluntary restrictions on smoking inside the home may present a public health benefit for infants in their first year of life. In light of inherent ecological study design limitations, these results warrant further individual level research linking postnatal SHS exposure and SIDS. Descriptors Links Book Title Database Publisher Data Source Authors Behm,I., Kabir,Z., Connolly,G.N., Alpert,H.R. Original/Translated Title URL Date of Electronic 20110407 PMCID Editors
Optimization of a novel method for determination of benzene, toluene, ethylbenzene, and xylenes in hair and waste water samples by carbon nanotubes reinforced sol-gel based hollow fiber solid phase microextraction and gas chromatography using factorial ex	2011	Department of Chemistry, Payame Noor University, Tehran, Iran. zarrin eshaghi@yahoo.com	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of chromatography.A Periodical, Abbrev. J.Chromatogr.A Pub Date Free Form 27-May Volume 1218 Issue 21 Start Page 3400 Other Pages 3406 Notes LR: 20151119; CI: Copyright (c) 2011; JID: 9318488; 0 (Benzene Derivatives); 0 (Nanotubes, Carbon); 0 (Water Pollutants, Chemical); 451W47IQ8X (Sodium Chloride); 2011/01/02 [received]; 2011/03/16 [revised]; 2011/03/17 [accepted]; 2011/04/12 [aheadofprint] Place of Publication Netherlands ISSN/ISBN 1873-3778; 0021-9673 Accession Number PMID: 21489540 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1016/j.chroma.2011.03.043 [doi] Output Language Unknown(0) PMID 21489540 Abstract A novel design of solid phase microextraction fiber containing carbon nanotube reinforced sol-gel which was protected by polypropylene hollow fiber (HF-SPME) was developed for pre-concentration and determination of BTEX in environmental waste water and human hair samples. The method validation was included and satisfying results with high pre-concentration factors were obtained. In the present study orthogonal array experimental design (OAD) procedure with OA(16) (4(4)) matrix was applied to study the effect of four factors influencing the HF-SPME method efficiency: stirring speed, volume of adsorption organic solvent, extraction and desorption time of the sample solution, by which the effect of each factor was estimated using individual contributions as response functions in the screening process. Analysis of variance (ANOVA) was employed for estimating the main significant factors and their percentage contributions in extraction. Calibration curves were plotted using ten spiking levels of BTEX in the concentration ranges of 0.02-30,000ng/mL with correlation coefficients (r) 0.989-0.9991 for analytes. Under the optimized extraction conditions, the method showed good linearity (0.3-20,000ng/L), repeatability, low limits of detections (0.49-0.7ng/L) and excellent pre-concentration factors (185-1872). The best conditions which were estimated then applied for the analysis of BTEX compounds in the real samples. Descriptors Links Book Title Database Publisher Elsevier B.V Data Source Authors Es'haghi,Z., Ebrahimi,M., Hosseini,M.S. Original/Translated Title URL Date of Electronic 20110412 PMCID Editors
A pilot clinical trial of varenicline for smoking cessation in black smokers	2011	Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA. nnollen@kumc.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Periodical, Abbrev. Nicotine Tob.Res. Pub Date Free Form Sep Volume 13 Issue 9 Start Page 868 Other Pages 873 Notes LR: 20151119; GR: P60MD003422/MD/NIMHD NIH HHS/United States; JID: 9815751; 0 (Benzazepines); 0 (Nicotinic Agonists); 0 (Quinoxalines); W6HS99O8ZO (Varenicline); OID: NLM: PMC3203399; 2011/04/15 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1469-994X; 1462-2203 Accession Number PMID: 21498427 Language eng SubFile Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1093/ntr/ntr063 [doi] Output Language Unknown(0) PMID 21498427 Abstract INTRODUCTION: Varenicline, a first-line non-nicotine medication, has not been evaluated in Black smokers, and limited attention has been paid to pharmacotherapy adherence in smoking cessation trials. This pilot study estimated quit rates for Black smokers treated with varenicline and tested a behavioral intervention to aid varenicline adherence. METHODS: Seventy-two Black smokers (>10 cigarettes per day; cpd) were randomly assigned to adherence support (AS; n = 36) or standard care (n = 36). All participants received 3 months of varenicline and a single counseling session focused on making a quit plan. AS participants received 5 additional counseling sessions to encourage medication use. Outcome measures included salivary cotinine, and carbon monoxide confirmed smoking abstinence, reductions in self-reported cpd, and pill counts of varenicline adherence at Months 1, 2, and 3. RESULTS: Sixty-one participants (84.7%) completed follow-up at Month 3. Participants were female (62.5%), 46.8 years of age, and smoked 16.3 cpd. No treatment group differences were found on the smoking or adherence outcome measures (p > .05). Collapsing across treatment, varenicline adherence was adequate (86.1%), yet despite a reduction of 12.2 (6.5) cpd from baseline to Month 3 (p < 0.001), only 23.6% were confirmed quit at Month 3. Participants who were quit at Month 3 had higher varenicline adherence rates (95.8%) than those who continued to smoke (80.8%, p </= .05). CONCLUSIONS: Studies are needed to examine the efficacy of varenicline among Black smokers. Interventions to facilitate adherence to pharmacotherapy warrant further attention as adherence is linked to improved tobacco abstinence. Descriptors Adult, African Americans, Behavior Therapy, Benzazepines/administration & dosage, Combined Modality Therapy, Counseling/methods, Female, Humans, Male, Medication Adherence, Middle Aged, Nicotinic Agonists/administration & dosage, Pilot Projects, Quinoxalines/administration & dosage, Smoking Cessation/ethnology/methods, Tobacco Use Disorder/drug therapy/ethnology, United States, Varenicline Links Book Title Database Publisher Data Source Authors Nollen,N. L., Cox,L. S., Nazir,N., Ellerbeck,E. F., Owen,A., Pankey,S., Thompson,N., Ahluwalia,J. S. Original/Translated Title URL Date of Electronic 20110415 PMCID PMC3203399 Editors
Incremental efficacy of adding bupropion to the nicotine patch for smoking cessation in smokers with a recent history of alcohol dependence: results from a randomized, double-blind, placebo-controlled study	2011	Univeristy of Massachusetts School of Medicine, Worcester, MA 01655, USA. david.kalman@umassmed.edu	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Drug and alcohol dependence Periodical, Abbrev. Drug Alcohol Depend. Pub Date Free Form 1-Nov Volume 118 Issue 3-Feb Start Page 111 Other Pages 118 Notes LR: 20151119; CI: Published by Elsevier Ireland Ltd.; GR: K01-DA-019446/DA/NIDA NIH HHS/United States; GR: R01 DA017370-06/DA/NIDA NIH HHS/United States; GR: R01-DA11713-01/DA/NIDA NIH HHS/United States; JID: 7513587; 0 (Nicotinic Agonists); 01ZG3TPX31 (B Place of Publication Ireland ISSN/ISBN 1879-0046; 0376-8716 Accession Number PMID: 21507585 Language eng SubFile Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; IM DOI 10.1016/j.drugalcdep.2011.03.005 [doi] Output Language Unknown(0) PMID 21507585 Abstract AIMS: The primary aim of this study was to compare the efficacy of smoking cessation treatment using a combination of nicotine patch and bupropion vs. nicotine patch and placebo bupropion. A secondary aim was to investigate whether the efficacy of bupropion is moderated by belief about whether one is receiving active or placebo medication. METHODS: Participants were recruited from a residential substance abuse treatment program and the community. We randomly assigned 148 smokers with between 2 and 12 months of alcohol abstinence to nicotine patch plus bupropion or nicotine patch plus placebo. All participants also received seven counseling sessions. RESULTS: At follow up, differences between medication conditions were not significant. Seven-day point prevalence quit rates in the patch plus bupropion vs. patch plus placebo conditions at week 24 were 6% and 11%, respectively. Differences between groups on prolonged abstinence and time to first smoking lapse were also not significant. However, among participants who received bupropion, those who accurately "guessed" that they were receiving bupropion were more likely to remain abstinent than those who incorrectly believed they were receiving placebo. CONCLUSIONS: Findings do not support combining nicotine patch and bupropion for smoking cessation in this population. However, findings support previous studies suggesting the importance of assessing the blind in smoking cessation studies and its possible moderating effect on medication efficacy. Future directions for enhancing smoking cessation outcome in these smokers include investigations of intensive behavioral and pharmacological interventions, including studies of potential interactions between individual genetic differences and medication efficacy. Descriptors Links Book Title Database Publisher Data Source Authors Kalman,D., Herz,L., Monti,P., Kahler,C.W., Mooney,M., Rodrigues,S., O'Connor,K. Original/Translated Title URL Date of Electronic 20110419 PMCID PMC3142284 Editors
Effects of fluconazole, amphotericin B, and caspofungin on Candida albicans biofilms under conditions of flow and on biofilm dispersion	2011	Department of Biology, South Texas Center for Emerging Infectious Diseases,The University of Texas at San Antonio, San Antonio, Texas 78249, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Antimicrobial Agents and Chemotherapy Periodical, Abbrev. Antimicrob.Agents Chemother. Pub Date Free Form Jul Volume 55 Issue 7 Start Page 3591 Other Pages 3593 Notes LR: 20150204; GR: R21AI080930/AI/NIAID NIH HHS/United States; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL63 (caspofungin); OID: NLM: PMC3122381; 2011/04/25 [aheadofprint]; ppublis Place of Publication United States ISSN/ISBN 1098-6596; 0066-4804 Accession Number PMID: 21518839 Language eng SubFile Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM DOI 10.1128/AAC.01701-10 [doi] Output Language Unknown(0) PMID 21518839 Abstract We have examined the effect of continuous perfusion with antifungals on Candida albicans biofilms under conditions of flow, closely mimicking physiological conditions encountered within patients. Biofilms displayed high levels of resistance to fluconazole, and this antifungal exerted minor effects on dispersion levels. Amphotericin B proved effective in reducing viability of cells within the biofilms and dispersion, but only at high concentrations. Under flow conditions, caspofungin exhibited potent activity against biofilms and drastically reduced biofilm dispersion. Descriptors Links Book Title Database Publisher Data Source Authors Uppuluri,P., Srinivasan,A., Ramasubramanian,A., Lopez-Ribot,J.L. Original/Translated Title URL Date of Electronic 20110425 PMCID PMC3122381 Editors

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