WTS database

Title	Pub Year	Author Sort descending	SearchLink
In vitro activity of antifungal combinations against Candida albicans biofilms	2010	Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Wahringer Gurtel 18-20, 1090 Vienna, Austria.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Journal of antimicrobial chemotherapy Periodical, Abbrev. J.Antimicrob.Chemother. Pub Date Free Form Feb Volume 65 Issue 2 Start Page 271 Other Pages 274 Notes LR: 20131125; JID: 7513617; 0 (Antifungal Agents); 0 (Echinocandins); 0 (Triazoles); 6TK1G07BHZ (posaconazole); 7XU7A7DROE (Amphotericin B); F0XDI6ZL63 (caspofungin); 2009/12/08 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1460-2091; 0305-7453 Accession Number PMID: 19996142 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1093/jac/dkp429 [doi] Output Language Unknown(0) PMID 19996142 Abstract OBJECTIVES: The aim of the present study was to evaluate the in vitro activity and synergism of the combinations of amphotericin B/caspofungin and amphotericin B/posaconazole against Candida albicans, grown either as planktonic cells or in biofilms. METHODS: Ten C. albicans bloodstream isolates used in this study were collected from intensive care patients admitted to the Vienna University Hospital between 2006 and 2007. Chequerboard tests were employed to determine the efficacy of the antifungal combinations amphotericin B/caspofungin and amphotericin B/posaconazole against both planktonic cells and biofilms. C. albicans biofilms were prepared using the static microtitre plate model. The activity of antifungal combination therapy was determined by visual reading for planktonic cells and using the XTT assay for biofilms. RESULTS: For Candida biofilms the median MIC was 4 mg/L for amphotericin B and caspofungin, and >256 mg/L for posaconazole. The combination amphotericin B/posaconazole yielded synergism [fractional inhibitory concentration index (FICI) <0.26], whereas amphotericin B/caspofungin yielded indifferent interaction only (FICI 0.75-1.25) against all isolates when grown in biofilms. Under planktonic conditions, synergism was demonstrable for the combination amphotericin B/caspofungin against 4 of the 10 isolates, whereas the combination of caspofungin/posaconazole was indifferent against all tested isolates. CONCLUSIONS: We showed that MICs for planktonic and biofilm forms of C. albicans were much lower when treated with an antifungal combination than when treated with single agents. The combination of amphotericin B/posaconazole yielded synergism against Candida biofilms, whereas amphotericin B/caspofungin yielded indifferent interaction. Descriptors Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Austria, Biofilms/drug effects, Candida albicans/drug effects/isolation & purification, Candidiasis/microbiology, Drug Synergism, Echinocandins/pharmacology, Fungemia/microbiology, Humans, Intensive Care Units, Microbial Sensitivity Tests, Triazoles/pharmacology Links Book Title Database Publisher Data Source Authors Tobudic,S., Kratzer,C., Lassnigg,A., Graninger,W., Presterl,E. Original/Translated Title URL Date of Electronic 20091208 PMCID Editors
Relation of exercise capacity with lung volumes before and after 6-minute walk test in subjects with COPD	2014	Department of Internal Medicine II, University Hospital of Ulm, Ulm, Germany. thomas.wibmer@gmx.de.; Department of Internal Medicine II, University Hospital of Ulm, Ulm, Germany.; Department of Internal Medicine II, University Hospital of Ulm, Ulm, German	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Respiratory care Periodical, Abbrev. Respir.Care Pub Date Free Form Nov Volume 59 Issue 11 Start Page 1687 Other Pages 1695 Notes CI: Copyright (c) 2014; JID: 7510357; OTO: NOTNLM; 2014/09/23 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1943-3654; 0020-1324 Accession Number PMID: 25249649 Language eng SubFile Journal Article; IM DOI 10.4187/respcare.03082 [doi] Output Language Unknown(0) PMID 25249649 Abstract INTRODUCTION: There is growing evidence that exercise-induced variation in lung volumes is an important source of ventilatory limitation and is linked to exercise intolerance in COPD. The aim of this study was to compare the correlations of walk distance and lung volumes measured before and after a 6-min walk test (6MWT) in subjects with COPD. METHODS: Forty-five subjects with stable COPD (mean pre-bronchodilator FEV1: 47 +/- 18% predicted) underwent a 6MWT. Body plethysmography was performed immediately pre- and post-6MWT. RESULTS: Correlations were generally stronger between 6-min walk distance and post-6MWT lung volumes than between 6-min walk distance and pre-6MWT lung volumes, except for FEV1. These differences in Pearson correlation coefficients were significant for residual volume expressed as percent of total lung capacity (-0.67 vs -0.58, P = .043), percent of predicted residual volume expressed as percent of total lung capacity (-0.68 vs -0.59, P = .026), inspiratory vital capacity (0.65 vs 0.54, P = .019), percent of predicted inspiratory vital capacity (0.49 vs 0.38, P = .037), and percent of predicted functional residual capacity (-0.62 vs -0.47, P = .023). CONCLUSIONS: In subjects with stable COPD, lung volumes measured immediately after 6MWT are more closely related to exercise limitation than baseline lung volumes measured before 6MWT, except for FEV1. Therefore, pulmonary function testing immediately after exercise should be included in future studies on COPD for the assessment of exercise-induced ventilatory constraints to physical performance that cannot be adequately assessed from baseline pulmonary function testing at rest. Descriptors Links Book Title Database Publisher by Daedalus Enterprises Data Source Authors Wibmer,T., Rudiger,S., Kropf-Sanchen,C., Stoiber,K.M., Rottbauer,W., Schumann,C. Original/Translated Title URL Date of Electronic 20140923 PMCID Editors
Smoking among Lebanese medical students: Prevalence and attitudes	2016	Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.; Department of Internal Medicine, American University of Beiru	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of thoracic medicine Periodical, Abbrev. Ann.Thorac.Med. Pub Date Free Form Jul-Sep Volume 11 Issue 3 Start Page 183 Other Pages 190 Notes LR: 20160814; JID: 101280721; OID: NLM: PMC4966220; OTO: NOTNLM; ppublish Place of Publication India ISSN/ISBN 1817-1737; 1998-3557 Accession Number PMID: 27512507 Language eng SubFile Journal Article DOI 10.4103/1817-1737.185757 [doi] Output Language Unknown(0) PMID 27512507 Abstract INTRODUCTION: The tobacco epidemic is a major public health threat facing the world. Tobacco dependence is recognized as the greatest preventable cause of disease and death. Medical students are in key position influencing future tobacco cessation programs. OBJECTIVES: The primary objective of this study is to evaluate the prevalence of smoking among medical students across Lebanon and their smoking attitudes. It also investigates their attitude toward smoking, showing where they really stand on this major public health issue. This study helps better tackle anti-smoking campaigns among both physicians and patients. METHODS: This cross-sectional study was conducted by sending a questionnaire to currently enrolled medical students at all seven medical schools in Lebanon. The 32-item questionnaire was used, comprised three sections assessing sociodemographic characteristics, smoking habits, and attitudes toward smoking among Lebanese medical students. The questionnaire was launched online on Limesurvey to retain anonymity. The data were then transferred to Statistical Package for Social Sciences for analysis. Data were expressed as percentages for discrete variables and as mean +/- standard deviation for continuous variables. RESULTS: One hundred sixty-three complete responses remained of the 182 obtained responses. Forty-two of the total 163 students identified themselves as either daily or occasional smokers yielding a prevalence of 25.8%. Smokers were less likely to ask patients about their smoking habit and to counsel them about smoking cessation. Almost one-third of smokers felt that they had no obligations toward the society. CONCLUSION: Approximately 1 in 4 Lebanese medical students is a smoker. Students who smoke are less likely to ask patients about their smoking habits and to counsel them on smoking cessation. This is a major drawback in the fight against tobacco. This calls for better education of our future doctors on smoking cessation to decrease the smoking burden on our Lebanese society and worldwide. Descriptors Links Book Title Database Publisher Data Source Authors Chidiac,A., Tamim,H., Kanso,M., Tfayli,A. Original/Translated Title URL Date of Electronic PMCID PMC4966220 Editors
The allure of the waterpipe: a narrative review of factors affecting the epidemic rise in waterpipe smoking among young persons globally	2015	Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.; School of Public Health, University of Memphis, Memphis, Tennessee, USA.; Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.; Faculty of Health Scie	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco control Periodical, Abbrev. Tob.Control Pub Date Free Form Mar Volume 24 Suppl 1 Issue Start Page i13 Other Pages i21 Notes LR: 20150319; CI: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.; JID: 9209612; 059QF0KO0R (Water); OID: NLM: PMC434597 Place of Publication England ISSN/ISBN 1468-3318; 0964-4563 Accession Number PMID: 25618895 Language eng SubFile Journal Article; Review; IM DOI 10.1136/tobaccocontrol-2014-051906 [doi] Output Language Unknown(0) PMID 25618895 Abstract OBJECTIVE: The objective of this narrative review is to highlight the determinants of the epidemic rise in waterpipe tobacco smoking (WTS) among youth globally. The Ecological Model of Health Promotion (EMHP) was the guiding framework for the review. DATA SOURCES: The following electronic databases were searched: Cochrane library, MEDLINE, EMBASE, PsycINFO, Web of Science and CINAHL Plus with Full Text. Search terms included waterpipe and its many variant terms. STUDY SELECTION: Articles were included if they were published between 1990 and 2014, were in English, were available in full text and included the age group 10-29 years. DATA EXTRACTION: Articles which analysed determinants of WTS at any of the levels of the EMHP were retained regardless of methodological rigour: 131 articles are included. Articles were coded in a standard template that abstracted methods as well as results. DATA SYNTHESIS: The review found that methodologies used to assess determinants of WTS among youth were often conventional and lacked rigor: 3/4 of the studies were cross-sectional surveys and most enrolled non-representative samples. Within the framework, the review identified determinants of WTS at the intrapersonal, interpersonal, organisational, community and policy levels. CONCLUSIONS: The review suggests potential interventions to control WTS among youth, with emphasis on creative utilisation of social media, and tobacco control policies that include the specificities of WTS. The review further suggests the need for rigorous qualitative work to better contextualise determinants, and prospective observational and experimental studies that track and manipulate them to assess their viability as intervention targets. Descriptors Links Book Title Database Publisher Data Source Authors Akl,E.A., Ward,K.D., Bteddini,D., Khaliel,R., Alexander,A.C., Lotfi,T., Alaouie,H., Afifi,R.A. Original/Translated Title URL Date of Electronic 20150124 PMCID PMC4345979 Editors
Antifungal susceptibility to amphotericin B, fluconazole, voriconazole, and flucytosine in Candida bloodstream isolates from 15 tertiary hospitals in Korea	2012	Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of laboratory medicine Periodical, Abbrev. Ann.Lab.Med. Pub Date Free Form Nov Volume 32 Issue 6 Start Page 426 Other Pages 428 Notes LR: 20150222; JID: 101571172; 0 (Antifungal Agents); 0 (Pyrimidines); 0 (Triazoles); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); D83282DT06 (Flucytosine); JFU09I87TR (Voriconazole); OID: NLM: PMC3486937; OTO: NOTNLM; 2012/06/07 [received]; 2012 Place of Publication Korea (South) ISSN/ISBN 2234-3814; 2234-3806 Accession Number PMID: 23130342 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.3343/alm.2012.32.6.426 [doi] Output Language Unknown(0) PMID 23130342 Abstract The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMerieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea. Descriptors Links Book Title Database Publisher Data Source Authors Jung,S.I., Shin,J.H., Choi,H.J., Ju,M.Y., Kim,S.H., Lee,W.G., Park,Y.J., Lee,K., Korean Study Group for Candidemia Original/Translated Title URL Date of Electronic 20121017 PMCID PMC3486937 Editors
Current status of Barrett's esophagus research in Asia	2011	Department of Internal Medicine, E-Da Hospital and I-Shou University, Kaohsiung County, Taiwan.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of gastroenterology and hepatology Periodical, Abbrev. J.Gastroenterol.Hepatol. Pub Date Free Form Feb Volume 26 Issue 2 Start Page 240 Other Pages 246 Notes LR: 20150325; CI: (c) 2011; GR: CZB/4/709/Chief Scientist Office/United Kingdom; GR: ZIA CP010136-15/Intramural NIH HHS/United States; JID: 8607909; NIHMS256182; OID: NLM: NIHMS256182; OID: NLM: PMC3026914; ppublish Place of Publication Australia ISSN/ISBN 1440-1746; 0815-9319 Accession Number PMID: 21155883 Language eng SubFile Journal Article; Review; IM DOI 10.1111/j.1440-1746.2010.06529.x [doi] Output Language Unknown(0) PMID 21155883 Abstract In Western countries, the epidemiology of esophageal cancer has changed considerably over the past decades with a rise in the ratio of adenocarcinoma to squamous cell carcinoma. Although the prevalence of gastroesophageal reflux is increasing in Asia, the prevalences of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have remained low in most Asian countries. The Asian Barrett's Consortium recently conducted a review of published studies on BE from Asia to assess the current status of BE research in Asia, and to recommend potential areas for future BE research in the region. Differences in study design, enrolled population, and endoscopic biopsy protocols used have led to substantial variability in the reported BE prevalence (0.06% to 19.9%) across Asia. In particular, some Japanese studies used diagnostic criteria that differed considerably from what was used in most Asian studies. As in Western countries, increased age, male sex, tobacco smoking, reflux symptoms, and erosive esophagitis have been found to be risk factors for BE in several case-control studies from Asia. The Prague C and M criteria, developed to provide better interobserver reliability in diagnosis and grading of BE, are currently under extensive evaluation in the Asian population. There is a need for standardized protocols for endoscopic and histopathologic diagnosis before initiating collaborative projects to identify etiologic determinants of BE and its ensuing malignant transformation. At present, data regarding the management and long-term outcome of BE are extremely limited in Asia. More studies of BE in this geographic area are warranted. Descriptors Links Book Title Database Publisher Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd Data Source Authors Chang,C.Y., Cook,M.B., Lee,Y.C., Lin,J.T., Ando,T., Bhatia,S., Chow,W.H., El-Omar,E.M., Goto,H., Li,Y.Q., McColl,K., Reddy,N., Rhee,P.L., Sharma,P., Sung,J.J., Ghoshal,U., Wong,J.Y., Wu,J.C., Zhang,J., Ho,K.Y., Asian Barrett's Consortium Original/Translated Title URL Date of Electronic PMCID PMC3026914 Editors
Barrett esophagus in Asia: same disease with different pattern	2014	Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.; Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Clinical endoscopy Periodical, Abbrev. Clin.Endosc. Pub Date Free Form Jan Volume 47 Issue 1 Start Page 15 Other Pages 22 Notes LR: 20140624; JID: 101576886; OID: NLM: PMC3928486; OTO: NOTNLM; 2013/12/01 [received]; 2013/12/16 [revised]; 2014/01/02 [accepted]; 2014/01/24 [epublish]; ppublish Place of Publication Korea (South) ISSN/ISBN 2234-2400; 2234-2400 Accession Number PMID: 24570879 Language eng SubFile Journal Article; Review DOI 10.5946/ce.2014.47.1.15 [doi] Output Language Unknown(0) PMID 24570879 Abstract Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia. Descriptors Links Book Title Database Publisher Data Source Authors Lee,H.S., Jeon,S.W. Original/Translated Title URL Date of Electronic 20140124 PMCID PMC3928486 Editors
Clinical features of patients with infections caused by Candida guilliermondii and Candida fermentati and antifungal susceptibility of the isolates at a medical centre in Taiwan, 2001-10	2013	Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full The Journal of antimicrobial chemotherapy Periodical, Abbrev. J.Antimicrob.Chemother. Pub Date Free Form Nov Volume 68 Issue 11 Start Page 2632 Other Pages 2635 Notes JID: 7513617; 0 (Antifungal Agents); OTO: NOTNLM; 2013/06/13 [aheadofprint]; ppublish Place of Publication England ISSN/ISBN 1460-2091; 0305-7453 Accession Number PMID: 23766486 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1093/jac/dkt214 [doi] Output Language Unknown(0) PMID 23766486 Abstract OBJECTIVES: This study was intended to analyse the clinical characteristics and outcomes of patients with infections due to Candida guilliermondii complex and evaluate in vitro susceptibilities of the isolates. METHODS: We searched the Mycology Database of the National Taiwan University Hospital and identified patients with infections due to C. guilliermondii complex from 2001 to 2010. Isolates were identified to species level by two yeast identification systems and restriction fragment length polymorphism of the riboflavin synthetase gene. MICs of nine antifungal agents were determined using the Sensititre YeastOne system (Trek Diagnostic Systems) and were interpreted by breakpoints (BPs) for three echinocandins and epidemiological cut-off values (ECVs) for the other agents. RESULTS: Fifty-two patients with infections due to C. guilliermondii complex were evaluated. The majority (90%, n = 47) of the isolates were C. guilliermondii, followed by Candida fermentati (10%, n = 5). Among them, 42 (81%) were isolated from blood cultures. Among the 52 patients, 27 (52%) had underlying malignancy and 15 (29%) had undergone abdominal surgery. The 30 day mortality rates among patients with C. guilliermondii and C. fermentati infections were 45% and 60%, respectively. Among C. guilliermondii isolates, 98%, 100% and 98% were susceptible to caspofungin, micafungin and anidulafungin, respectively, by BPs. Nearly all (96%-100%) C. guilliermondii isolates belonged to wild-type for the other agents by ECVs. All five C. fermentati were susceptible to three echinocandins and belonged to wild-type for the other agents. CONCLUSIONS: The currently used antifungal agents exhibited good in vitro activities against C. guilliermondii complex isolates. Descriptors Links Book Title Database Publisher Data Source Authors Chen,C.Y., Huang,S.Y., Tang,J.L., Tsay,W., Yao,M., Ko,B.S., Chou,W.C., Tien,H.F., Hsueh,P.R. Original/Translated Title URL Date of Electronic 20130613 PMCID Editors
Association of esophageal inflammation, obesity and gastroesophageal reflux disease: from FDG PET/CT perspective	2014	Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Nuclear Medicine and Cardiology Division of Cardiovascular Medical Cen	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full PloS one Periodical, Abbrev. PLoS One Pub Date Free Form 18-Mar Volume 9 Issue 3 Start Page e92001 Other Pages Notes LR: 20151119; JID: 101285081; 0Z5B2CJX4D (Fluorodeoxyglucose F18); OID: NLM: PMC3958434; 2014 [ecollection]; 2013/11/22 [received]; 2014/02/15 [accepted]; 2014/03/18 [epublish]; epublish Place of Publication United States ISSN/ISBN 1932-6203; 1932-6203 Accession Number PMID: 24642729 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1371/journal.pone.0092001 [doi] Output Language Unknown(0) PMID 24642729 Abstract OBJECTIVE: Gastroesophageal reflux disease (GERD) is associated with bothersome symptoms and neoplastic progression into Barrett's esophagus and esophageal adenocarcinoma. We aim to determine the correlation between GERD, esophageal inflammation and obesity with 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). METHODS: We studied 458 subjects who underwent a comprehensive health check-up, which included an upper gastrointestinal endoscopy, FDG PET/CT and complete anthropometric measures. GERD symptoms were evaluated with Reflux Disease Questionnaire. Endoscopically erosive esophagitis was scored using the Los Angeles classification system. Inflammatory activity, represented by standardized uptake values (SUVmax) of FDG at pre-determined locations of esophagus, stomach and duodenum, were compared. Association between erosive esophagitis, FDG activity and anthropometric evaluation, including body mass index (BMI), waist circumference, visceral and subcutaneous adipose tissue volumes were analyzed. RESULTS: Subjects with erosive esophagitis (n = 178, 38.9%) had significantly higher SUVmax at middle esophagus (2.69+/-0.74 vs. 2.41+/-0.57, P<.001 and="" esophagogastric="" junction="" vs.="" p="" marginally="" higher="" at="" upper="" esophageal="" sphincter="" but="" not="" in="" stomach="" or="" duodenum.="" the="" severity="" of="" erosive="" esophagitis="" correlated="" with="" suvmax="" subjects="" barrett="" esophagus="" had="" highest="" middle="" junction.="" heartburn="" positively="" oesophagus="" .262="" using="" multivariate="" regression="" analyses="" age="" .027="" total="" cholesterol="" level="" .003="" alcohol="" drinking="" .03="" subcutaneous="" adipose="" tissue="" bmi="" waist="" circumference="" were="" independently="" associated="" respective="" locations.="" conclusions:="" inflammation="" demonstrated="" by="" fdg="" pet="" correlates="" endoscopic="" findings="" symptomatology="" gerd.="" obesity="" markers="" both="" visceral="" general="" are="" independent="" determinants="" inflammation.=""> Descriptors Links Book Title Database Publisher Data Source Authors Wu,Y.W., Tseng,P.H., Lee,Y.C., Wang,S.Y., Chiu,H.M., Tu,C.H., Wang,H.P., Lin,J.T., Wu,M.S., Yang,W.S. Original/Translated Title URL Date of Electronic 20140318 PMCID PMC3958434 Editors
Interobserver reliability in the endoscopic diagnosis and grading of Barrett's esophagus: an Asian multinational study	2010	Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Endoscopy Periodical, Abbrev. Endoscopy Pub Date Free Form Sep Volume 42 Issue 9 Start Page 699 Other Pages 704 Notes LR: 20150325; CI: Copyright Georg Thieme Verlag KG Stuttgart . New York.; GR: ZIA CP010136-15/Intramural NIH HHS/United States; JID: 0215166; NIHMS256200; OID: NLM: NIHMS256200; OID: NLM: PMC3000217; 2010/08/30 [epublish]; ppublish Place of Publication Germany ISSN/ISBN 1438-8812; 0013-726X Accession Number PMID: 20806154 Language eng SubFile Journal Article; Multicenter Study; IM DOI 10.1055/s-0030-1255629 [doi] Output Language Unknown(0) PMID 20806154 Abstract BACKGROUND AND STUDY AIM: The establishment of precise and valid diagnostic criteria is important for any disease. We determined the interobserver reliability in the endoscopic diagnosis and grading of Barrett's esophagus. PATIENTS AND METHODS: Video clips of endoscopy in 21 patients with/without Barrett's esophagus were used for training (n = 3) and for diagnosis/grading (n = 18) of Barrett's esophagus by endoscopists from seven hospitals in Asia. Barrett's esophagus was graded using the Prague C & M Criteria whereby the circumferential extent of the Barrett's segment (C value), maximum extent of Barrett's segment (M value), location of the gastroesophageal junction, and location of the diaphragmatic hiatus were scored. The intraclass correlation coefficients (ICC) were calculated as a measure of interobserver reliability. RESULTS: A total of 34 endoscopists participated. ICC values for the scores of the C value, M value, location of the gastroesophageal junction, and location of the diaphragmatic hiatus were: 0.92 (95 % confidence interval [CI] 0.88 - 0.97), 0.94 (95 %CI 0.90 - 0.98), 0.86 (95 %CI 0.78 - 0.94), and 0.81 (95 %CI 0.71 - 0.92), respectively, indicating excellent interobserver agreement. The differences in region/country, endoscopists' experience, case volume of participating centers, or primary practice type had no significant effect on the reliability. The ICC values for recognition of Barrett's esophagus of > or = 1 cm were 0.90 (95 %CI 0.80 - 1.00) and 0.92 (95 %CI 0.87 - 0.98) for the C and M values, respectively, whereas the corresponding ICC values for Barrett's segment of < 1 cm were 0.18 (95 %CI 0.03 - 0.32) and 0.21 (95 %CI 0.00 - 0.51), respectively. CONCLUSIONS: Despite the uncommon occurrence of Barrett's esophagus in Asia, our endoscopists exhibited excellent agreement in the endoscopic diagnosis and grading of Barrett's esophagus using the Prague C & M Criteria. However, in view of the low interobserver reliability in recognizing Barrett's segments of < 1 cm, future studies in Asia should take this into account when selecting the study population. Descriptors Asia, Barrett Esophagus/diagnosis/pathology, Clinical Competence/statistics & numerical data, Esophagoscopy/standards, Humans, Observer Variation, Reproducibility of Results Links Book Title Database Publisher Data Source Authors Lee,Y. C., Cook,M. B., Bhatia,S., Chow,W. H., El-Omar,E. M., Goto,H., Lin,J. T., Li,Y. Q., Rhee,P. L., Sharma,P., Sung,J. J., Wong,J. Y., Wu,J. C., Ho,K. Y., Asian Barrett's Consortium Original/Translated Title URL Date of Electronic 20100830 PMCID PMC3000217 Editors

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