WTS database

Title	Pub Year	Author Sort ascending	SearchLink
Barrett's esophagus: a surgical disease	1999	Department of Surgery, University of California, San Francisco, San Francisco, California 94143-0788, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Periodical, Abbrev. J.Gastrointest.Surg. Pub Date Free Form Jul-Aug Volume 3 Issue 4 Start Page 397 Other Pages 403; discussion 403-4 Notes LR: 20041117; JID: 9706084; ppublish Place of Publication UNITED STATES ISSN/ISBN 1091-255X; 1091-255X Accession Number PMID: 10482692 Language eng SubFile Journal Article; IM DOI S1091255X99800560 [pii] Output Language Unknown(0) PMID 10482692 Abstract Barrett's metaplasia can develop in patients with gastroesophageal reflux disease (GERD), and metaplasia can evolve into dysplasia and adenocarcinoma. The optimal treatment for Barrett's metaplasia and dysplasia is still being debated. The study reported herein was designed to assess the following: (1) the incidence of Barrett's metaplasia among patients with GERD; (2) the ability of laparoscopic fundoplication to control symptoms in patients with Barrett's metaplasia; (3) the results of esophagectomy in patients with high-grade dysplasia; and (4) the character of endoscopic follow-up programs of patients with Barrett's disease being managed by physicians throughout a large geographic region (northern California). Five-hundred thirty-five patients evaluated between October 1989 and February 1997 at the University of California San Francisco Swallowing Center had a diagnosis of GERD established by upper gastrointestinal series, endoscopy, manometry, and pH monitoring. Thirty-eight symptomatic patients with GERD and Barrett's metaplasia underwent laparoscopic fundoplication. Eleven other consecutive patients with high-grade dysplasia underwent transhiatal esophagectomies. Barrett's metaplasia was present in 72 (13%) of the 535 patients with GERD. The following results were achieved in patients who underwent laparoscopic fundoplication (n = 38): Heartburn resolved in 95% of patients, regurgitation in 93% of patients, and cough in 100% of patients. With regard to transhiatal esophagectomy (n = 11), the average duration of the operation was 339 +/- 89 minutes. The only significant complications were two esophageal anastomotic leaks, both of which resolved without sequelae. Mean hospital stay was 14 +/- 5 days. There were no deaths. The specimens showed high-grade dysplasia in seven patients and invasive adenocarcinoma (undiagnosed preoperatively) in four (36%). These results can be summarized as follows: (1) Barrett's metaplasia was present in 13% of patients with GERD being evaluated at a busy diagnostic center; (2) laparoscopic fundoplication was highly successful in controlling symptoms of GERD in patients with Barrett's metaplasia; (3) in patients with high-grade dysplasia esophagectomy was performed safely (invasive cancer had eluded preoperative endoscopic biopsies in one third of these patients); and (4) even though periodic endoscopic examination of Barrett's disease is universally recommended, this was actually done in fewer than two thirds of patients being managed by a large number of independent physicians in this geographic area. Descriptors Adenocarcinoma/pathology, Adult, Aged, Aged, 80 and over, Anastomosis, Surgical/adverse effects, Barrett Esophagus/etiology/pathology/surgery, California, Cough/therapy, Esophageal Neoplasms/pathology, Esophagectomy/adverse effects, Esophagoscopy, Esophagus/pathology, Female, Follow-Up Studies, Fundoplication, Gastroesophageal Reflux/complications, Heartburn/therapy, Humans, Hydrogen-Ion Concentration, Incidence, Laparoscopy, Length of Stay, Male, Manometry, Metaplasia, Middle Aged, Monitoring, Ambulatory, Time Factors Links Book Title Database Publisher Data Source Authors Patti,M. G., Arcerito,M., Feo,C. V., Worth,S., De Pinto,M., Gibbs,V. C., Gantert,W., Tyrrell,D., Ferrell,L. F., Way,L. W. Original/Translated Title URL Date of Electronic PMCID Editors
A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia	2015	Department of Surgery, Trinity Center for Health Sciences, St. James's Hospital and Trinity College Dublin, Dublin, Ireland.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Periodical, Abbrev. Dis.Esophagus Pub Date Free Form Feb-Mar Volume 28 Issue 2 Start Page 121 Other Pages 126 Notes CI: (c) 2014; JID: 8809160; Adenocarcinoma Of Esophagus; OTO: NOTNLM; 2014/01/15 [aheadofprint]; ppublish Place of Publication United States ISSN/ISBN 1442-2050; 1120-8694 Accession Number PMID: 24428806 Language eng SubFile Journal Article; Research Support, Non-U.S. Gov't; IM DOI 10.1111/dote.12166 [doi] Output Language Unknown(0) PMID 24428806 Abstract Barrett's esophagus (BE) arising from chronic gastro-oesophageal reflux (GERD) is the main pathologic precursor of esophageal adenocarcinoma (EAC). The risk of progression to high-grade dysplasia (HGD) and EAC is unclear, and recent population studies from Denmark and Northern Ireland suggest that this has been overestimated in the past. No data exist from the Republic of Ireland. A detailed clinical, endoscopic, and pathologic database was established in one center as a proposed pilot for a national registry, and initial and follow-up data were abstracted by a data manager. One thousand ninety-three patients were registered, 60 patients with HGD were excluded, leaving 1033, with a median age of 59 and 2 : 1 male to female ratio, and 3599 person-years of follow-up. The overall incidence of HGD/EAC was 1.33% per year overall, 0.85% if the first year is excluded. Within the first year after index endoscopy, 18 cases of HGD or EAC were identified, and 30 following the first year. Low-grade dysplasia (LGD) on index endoscopy was associated with an incidence of progression of 6.5% per year, and 3.1% when tertiary referrals were excluded. These data provide important demographic and clinical information on the population of Irish patients with BE, with incidence rates of progression higher than recently published population-based registry series, perhaps relating to sampling and pathological assessment. Low-grade dysplasia on initial biopsy is a significant proxy marker of risk of progression. Descriptors Links Book Title Database Publisher International Society for Diseases of the Esophagus Data Source Authors Picardo,S.L., O'Brien,M.P., Feighery,R., O'Toole,D., Ravi,N., O'Farrell,N.J., O'Sullivan,J.N., Reynolds,J.V. Original/Translated Title URL Date of Electronic 20140115 PMCID Editors
Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment	2010	Department of Surgery, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL 60153, USA.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Surgery Periodical, Abbrev. Surgery Pub Date Free Form Oct Volume 148 Issue 4 Start Page 737 Other Pages 44; discussion 744-5 Notes LR: 20141203; CI: Copyright (c) 2010; GR: T32 AA013527/AA/NIAAA NIH HHS/United States; GR: T32 AA013527-08/AA/NIAAA NIH HHS/United States; GR: T32 AA013527-09/AA/NIAAA NIH HHS/United States; JID: 0417347; NIHMS279574; OID: NLM: NIHMS279574; OID: NLM: PMC3 Place of Publication United States ISSN/ISBN 1532-7361; 0039-6060 Accession Number PMID: 20727564 Language eng SubFile Journal Article; AIM; IM DOI 10.1016/j.surg.2010.07.011 [doi] Output Language Unknown(0) PMID 20727564 Abstract BACKGROUND: Gastroesophageal reflux disease (GERD) is thought to be a risk factor for the development or progression of chronic rejection after lung transplantation. However, the prevalence of GERD and its risk factors, including esophageal dysmotility, hiatal hernia and delayed gastric emptying after lung transplantation, are still unknown. In addition, the prevalence of Barrett's esophagus, a known complication of GERD, has not been determined in these patients. The purpose of this study was to determine the prevalence and extent of GERD, as well as the frequency of these risk factors and complications of GERD in lung transplant patients. METHODS: Thirty-five consecutive patients underwent a combination of esophageal function testing, upper endoscopy, barium swallow, and gastric emptying scan after lung transplantation. RESULTS: In this patient population, the prevalence of GERD was 51% and 22% in those who had been retransplanted. Of patients with GERD,36% had ineffective esophageal motility (IEM), compared with 6% of patients without GERD (P = .037). No patient demonstrated hiatal hernia on barium swallow. The prevalence of delayed gastric emptying was 36%. The prevalence of biopsy-confirmed Barrett's esophagus was 12%. CONCLUSION: Our study shows that, after lung transplantation, more than half of patients had GERD, and that GERD was more common after retransplantation. IEM and delayed gastric emptying are frequent in patients with GERD. Hiatal hernia is rare. The prevalence of Barrett's esophagus is not negligible. We conclude that GERD is highly prevalent after lung transplantation, and that delayed gastric emptying and Barrett's esophagus should always be suspected after lung transplantation because they are common risks factors and complications of GERD. Descriptors Adult, Barrett Esophagus/epidemiology, Female, Gastroesophageal Reflux/diagnosis/epidemiology/etiology/physiopathology, Humans, Lung Transplantation, Male, Middle Aged, Prevalence, Risk Factors, Young Adult Links Book Title Database Publisher Mosby, Inc Data Source Authors Davis,C. S., Shankaran,V., Kovacs,E. J., Gagermeier,J., Dilling,D., Alex,C. G., Love,R. B., Sinacore,J., Fisichella,P. M. Original/Translated Title URL Date of Electronic 20100821 PMCID PMC3066258 Editors
Epidemiology of esophageal cancer, especially adenocarcinoma of the esophagus and esophagogastric junction	2000	Department of Surgery, Hospital Clinic y Provincial, University of Barcelona Medical School, Spain.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Recent results in cancer research.Fortschritte der Krebsforschung.Progres dans les recherches sur le cancer Periodical, Abbrev. Recent Results Cancer Res. Pub Date Free Form Volume 155 Issue Start Page 1 Other Pages 14 Notes LR: 20150828; JID: 0044671; RF: 82; ppublish Place of Publication GERMANY ISSN/ISBN 0080-0015; 0080-0015 Accession Number PMID: 10693234 Language eng SubFile Journal Article; Review; IM DOI Output Language Unknown(0) PMID 10693234 Abstract The incidence of adenocarcinoma of the esophagus and esophagogastric junction (EGJ) has been increasing over the past 15 years in western countries. Surgical series and population-based studies show that, by 1994, adenocarcinomas of the esophagus accounted for half of all esophageal cancer among white men. The causes of this increase in incidence remain to be elucidated. Esophageal adenocarcinomas and a portion of EGJ adenocarcinomas arise from long and short segments of specialized intestinal metaplasia (Barrett's esophagus). The prevalence of long segments of Barrett's esophagus (> 3 cm) in patients having endoscopy for reflux symptoms is 3%, and 1% in those undergoing endoscopy for any clinical indication. However, a silent majority of patients with Barrett's esophagus remain unrecognized in the general population and may not be diagnosed unless adenocarcinoma develops. Recent studies document a rise in the diagnosis of specialized intestinal metaplasia of the cardia. Nearly all these patients have associated carditis, and Helicobacter pylori infection has been linked to this condition. The possible origin of EGJ adenocarcinomas in the sequence carditis--specialized intestinal metaplasia needs to be clarified. Smoking and obesity are additional risk factors for adenocarcinoma of the esophagus and EGJ. Current data does not confirm H. pylori as a risk factor for cancer of the EGJ. Descriptors Adenocarcinoma/epidemiology/etiology/genetics, Barrett Esophagus/epidemiology/genetics, Esophageal Neoplasms/epidemiology/etiology/genetics, Esophagogastric Junction/pathology, Helicobacter Infections/complications, Humans, Incidence, Life Style Links Book Title Database Publisher Data Source Authors Pera,M. Original/Translated Title URL Date of Electronic PMCID Editors
Impact and duration of brief surgeon-delivered smoking cessation advice on attitudes regarding nicotine dependence and tobacco harms for patients with peripheral arterial disease	2016	Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; VA Outcomes Group, White River Junction, VT. Electronic address: Karina.A.Newhall@hitchcock.org.; Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH.; Sectio	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Annals of Vascular Surgery Periodical, Abbrev. Ann.Vasc.Surg. Pub Date Free Form 10-Aug Volume Issue Start Page Other Pages Notes LR: 20160813; CI: Published by Elsevier Inc.; JID: 8703941; 2016/02/06 [received]; 2016/05/31 [revised]; 2016/06/03 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1615-5947; 0890-5096 Accession Number PMID: 27521828 Language ENG SubFile JOURNAL ARTICLE DOI S0890-5096(16)30599-4 [pii] Output Language Unknown(0) PMID 27521828 Abstract BACKGROUND: Despite the recognized benefits of smoking cessation, many clinicians question if a brief smoking cessation intervention can help dedicated smokers with peripheral arterial disease understand nicotine dependence and harms related to smoking. We investigated the impact and durability of a multi-modal smoking cessation intervention on patient attitudes regarding nicotine dependence and the health effects of smoking. METHODS: We conducted a pilot cluster randomized trial of a brief smoking cessation intervention at eight vascular surgery practices between September 1, 2014 and August 31, 2015. Compared with control sites, patients at intervention sites received protocolized brief cessation counseling, medications and referrals to a quitline. After their clinic visit and again at 3 months, participants completed a brief survey about patient attitudes regarding nicotine dependence and the health effects of smoking. Responses to questions were analyzed using Chi2 and student's t-tests. RESULTS: All trial participants (n=156) complete the initial survey, and 75 (45%) participants completed the follow-up survey. Intervention and control patients both reported a greater than 30-pack-year history (80% vs 90%, p=0.07) and previous failed quit attempts (77% vs 78%, p=0.8). Compared to usual care, patients in the intervention group were more likely to describe hearing advice to quit from their surgeon (98% vs. 77%, p Descriptors Links Book Title Database Publisher Data Source Authors Newhall,K., Suckow,B., Spangler,E., Brooke,B.S., Schanzer,A., Tan,T., Burnette,M., Edelen,M.O., Farber,A., Goodney,P., VAPOR investigators (complete list in Appendix) Original/Translated Title URL Date of Electronic 20160810 PMCID Editors
A bizarre case of penetrating trauma	1986	Department of Surgery, American University of Beirut Medical Center, P.O. Box 113-6044, Beirut	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Pediatric surgery international Periodical, Abbrev. Pediatr.Surg.Int. Pub Date Free Form 1986/ Volume 1 Issue 4 Start Page 252 Other Pages 253 Notes Place of Publication ISSN/ISBN 0179-0358 Accession Number Language SubFile DOI Output Language Unknown(0) PMID Abstract An unusual case of penetrating trauma to the trunk by a water pipe during a car accident is presented. The only serious internal injury was an avulsion of the lower pole of the spleen, which was suture-repaired successfully after debridement. The line of management since admission is discussed. Follow-up after 1 year shows an asymptomatic and normally functioning young man. Descriptors radioisotope, accident, adolescent, bone, case report, diaphragm, diaphragm perforation, human, injury, respiratory system, rib fracture, spleen, spleen injury, surgery, therapy Links Book Title Database Embase Publisher Data Source Embase Authors Slim,M. S., Srouji,M. N., Sankari,M., Georgi,B. Original/Translated Title URL Date of Electronic PMCID Editors
Diagnosis and management of gastroesophageal reflux disease	2014	Department of Surgery and Orthopedy, School of Medicine, Sao Paulo State University, Botucatu, SP, Brazil.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery Periodical, Abbrev. Arq Bras.Cir.Dig. Pub Date Free Form Jul-Sep Volume 27 Issue 3 Start Page 210 Other Pages 215 Notes LR: 20160228; JID: 9100283; OID: NLM: PMC4676378; 2013/12/06 [received]; 2014/05/08 [accepted]; ppublish Place of Publication Brazil ISSN/ISBN 2317-6326; 0102-6720 Accession Number PMID: 25184775 Language eng; por SubFile Journal Article; Review; IM DOI S0102-67202014000300210 [pii] Output Language Unknown(0) PMID 25184775 Abstract INTRODUCTION: Gastroesophageal reflux disease (GERD) is probably one of the most prevalent diseases in the world that also compromises the quality of life of the affected significantly. Its incidence in Brazil is 12%, corresponding to 20 million individuals. OBJECTIVE: To update the GERD management and the new trends on diagnosis and treatment, reviewing the international and Brazilian experience on it. METHOD: The literature review was based on papers published on Medline/Pubmed, SciELO, Lilacs, Embase and Cochrane crossing the following headings: gastroesophageal reflux disease, diagnosis, clinical treatment, surgery, fundoplication. RESULTS: Various factors are involved on GERD physiopathology, the most important being the transient lower esophageal sphincter relaxation. Clinical manifestations are heartburn, regurgitation (typical symptoms), cough, chest pain, asthma, hoarseness and throat clearing (atypical symptoms), which may be followed or not by typical symptoms. GERD patients may present complications such as peptic stenosis, hemorrhage, and Barrett's esophagus, which is the most important predisposing factor to adenocarcinoma. The GERD diagnosis must be based on the anamnesis and the symptoms must be evaluated in terms of duration, intensity, frequency, triggering and relief factors, pattern of evolution and impact on the patient's quality of life. The diagnosis requires confirmation with different exams. The goal of the clinical treatment is to relieve the symptoms and surgical treatment is indicated for patients who require continued drug use, with intolerance to prolonged clinical treatment and with GERD complications. CONCLUSION: GERD is a major digestive health problem and affect 12% of Brazilian people. The anamnesis is fundamental for the diagnosis of GERD, with special analysis of the typical and atypical symptoms (duration, intensity, frequency, triggering and relief factors, evolution and impact on the life quality). High digestive endoscopy and esophageal pHmetry are the most sensitive diagnosctic methods. The clinical treatment is useful in controlling the symptoms; however, the great problem is keeping the patients asymptomatic over time. Surgical treatment is indicated for patients who required continued drug use, intolerant to the drugs and with complicated forms of GERD. Descriptors Links Book Title Database Publisher Data Source Authors Henry,M.A. Original/Translated Title URL Date of Electronic PMCID PMC4676378 Editors
N-(2-{[5-Bromo-2-(piperidin-1-yl)pyrimidin-4-yl]sulfan-yl}-4-meth-oxy-phen-yl)ben zene-sulfonamide	2012	Department of Studies in Physics, Manasagangotri, University of Mysore, Mysore 570 006, India.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 1-Nov Volume 68 Issue Pt 11 Start Page o3209 Other Pages 10 Notes LR: 20130418; JID: 101089178; OID: NLM: PMC3515297; 2012/10/08 [received]; 2012/10/22 [accepted]; 2012/10/27 [epublish]; ppublish Place of Publication United States ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 23284517 Language eng SubFile Journal Article DOI 10.1107/S1600536812043668 [doi] Output Language Unknown(0) PMID 23284517 Abstract The title compound, C(22)H(23)BrN(4)O(3)S(2), crystallizes with two mol-ecules, A and B, in the asymmetric unit. In one of these, the meth-oxy group is disordered over two sets of sites in a 0.565 (9):0.435 (9) ratio. The benzene rings bridged by the sulfonamide group are tilted relative to each other by 37.4 (1) and 56.1 (1) degrees in mol-ecules A and B, respectively, while the dihedral angles between the sulfur-bridged pyrimidine and benzene rings are 72.4 (1) and 70.2 (1) degrees for A and B, respectively. The piperidine ring adopts a chair conformation in both mol-ecules. In the crystal, inversion dimers linked by pairs of N-Hcdots, three dots, centeredN hydrogen bonds occur for both A and B; the dimers are linked into [010] chains by C-Hcdots, three dots, centeredO hydrogen bonds. The crystal structure also features inversion-generated aromatic pi-pi stacking inter-actions between the pyrimidine rings for both mol-ecules [centroid-centroid distances = 3.412 (2) (mol-ecule A) and 3.396 (2) A (mol-ecule B)]. Descriptors Links Book Title Database Publisher Data Source Authors Kumar,M., Mallesha,L., Sridhar,M.A., Kapoor,K., Gupta,V.K., Kant,R. Original/Translated Title URL Date of Electronic 20121027 PMCID PMC3515297 Editors
Crystal structure of 3-benzoyl-2-[(5-bromo-2-hydroxy-3-meth-oxy-benzyl-idene)amino]-4,5,6,7-tetra-hydr o-benzo[b]thio-phene	2015	Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India.; Department of Chemistry, Keene State College, 229 Main Street, Keene, NH 03435-2001, USA.; Department of Studies in Chemistry, University of Mysore, Manasaga	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Crystallographic communications Periodical, Abbrev. Acta Crystallogr.E.Crystallogr.Commun. Pub Date Free Form 17-Jan Volume 71 Issue Pt 2 Start Page 176 Other Pages 179 Notes LR: 20150418; JID: 101648987; OID: NLM: PMC4384575; OTO: NOTNLM; 2015/02/01 [ecollection]; 2014/12/31 [received]; 2015/01/06 [accepted]; 2015/01/17 [epublish]; epublish Place of Publication England ISSN/ISBN 2056-9890 Accession Number PMID: 25878812 Language eng SubFile Journal Article DOI 10.1107/S2056989015000195 [doi] Output Language Unknown(0) PMID 25878812 Abstract In the cyclo-hexene ring of the title compound, C23H20BrNO3S, the -(CH2)4- atoms are positionally disordered [occupancy ratio = 0.753 (6):0.247 (6)]. The ring has a half-chair conformation for both the major and minor components. The dihedral angles between the mean plane of the thio-phene ring and those of the benzene and phenyl rings are 35.2 (4) and 57.7 (3) degrees , respectively. The planes of the two aryl rings are twisted with respect to each other by 86.4 (6) degrees . In the mol-ecule, there is an O-Hcdots, three dots, centeredN hydrogen bond forming an S(6) ring motif. In the crystal, mol-ecules are linked via C-Hcdots, three dots, centeredO hydrogen bonds, forming chains parallel to [100]. Descriptors Links Book Title Database Publisher Data Source Authors Kaur,M., Jasinski,J.P., Yathirajan,H.S., Glidewell,C., Byrappa,K. Original/Translated Title URL Date of Electronic 20150117 PMCID PMC4384575 Editors
1-(2-Amino-6-methyl-pyrimidin-4-yl)-N,N-dimethyl-piperidin-4-aminium chloride	2012	Department of Studies and Research in Chemistry, Tumkur University, Tumkur, Karnataka 572 103, India.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Acta crystallographica.Section E, Structure reports online Periodical, Abbrev. Acta Crystallogr.Sect.E.Struct.Rep.Online Pub Date Free Form 1-Dec Volume 68 Issue Pt 12 Start Page o3371 Other Pages Notes LR: 20130418; JID: 101089178; OID: NLM: PMC3588967; 2012/11/10 [received]; 2012/11/11 [accepted]; 2012/11/17 [epublish]; ppublish Place of Publication United States ISSN/ISBN 1600-5368; 1600-5368 Accession Number PMID: 23476203 Language eng SubFile Journal Article DOI 10.1107/S1600536812046533 [doi] Output Language Unknown(0) PMID 23476203 Abstract In the title mol-ecular salt, C12H22N5(+).Cl(-), the cation is protonated at the dimethyl-substituted tertiary N atom. The piperidine ring adopts a chair conformation with the exocyclic N-C bond in an equatorial orientation. The dihedral angle between the piperidine ring (all atoms) and the pyrimidine ring is 14.00 (1) degrees . In the crystal, the ions are connected by N-Hcdots, three dots, centeredN hydrogen bonds, forming inversion dimers, which are further connected by N-Hcdots, three dots, centeredCl hydrogen bonds. Aromatic pi-pi stacking inter-actions [centroid-centroid separation = 3.4790 (9) A] are also observed in the structure. Descriptors Links Book Title Database Publisher Data Source Authors Sreenivasa,S., Manojkumar,K.E., Suchetan,P.A., Srinivasan,T., Palakshamurthy,B.S., Velmurgan,D. Original/Translated Title URL Date of Electronic 20121117 PMCID PMC3588967 Editors

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