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Gender difference in gastro-esophageal reflux diseases 2016 Kiyotaka Asanuma, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi Prefecture 980-8574, Japan.; Kiyotaka Asanuma, Katsunori Iijima, Tooru Shimosegawa, Division of Gastroenterology, To
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
World journal of gastroenterology
Periodical, Abbrev.
World J.Gastroenterol.
Pub Date Free Form
7-Feb
Volume
22
Issue
5
Start Page
1800
Other Pages
1810
Notes
LR: 20160210; JID: 100883448; OID: NLM: PMC4724611; OTO: NOTNLM; 2015/06/25 [received]; 2015/10/07 [revised]; 2015/12/30 [accepted]; ppublish
Place of Publication
United States
ISSN/ISBN
2219-2840; 1007-9327
Accession Number
PMID: 26855539
Language
eng
SubFile
Journal Article; Review; IM
DOI
10.3748/wjg.v22.i5.1800 [doi]
Output Language
Unknown(0)
PMID
26855539
Abstract
The incidence of esophageal adenocarcinoma (EAC) has risen sharply in western countries over the past 4 decades. This type of cancer is considered to follow a transitional process that goes from gastro-esophageal reflux disease (GERD) to Barrett's esophagus (BE, a metaplastic condition of the distal esophagus), a precursor lesion and ultimately adenocarcinoma. This spectrum of GERD is strongly predominant in males due to an unidentified mechanism. Several epidemiologic studies have described that the prevalence of GERD, BE and EAC in women is closely related to reproductive status, which suggests a possible association with the estrogen level. Recently, we revealed in an in vivo study that the inactivation of mast cells by the anti-inflammatory function of estrogen may account for the gender difference in the GERD spectrum. Other studies have described the contribution of female steroid hormones to the gender difference in these diseases. Estrogen is reported to modulate the metabolism of fat, and obesity is a main risk factor of GERDs. Moreover, estrogen could confer esophageal epithelial resistance to causative refluxate. These functions of estrogen might explain the approximately 20-year delay in the incidence of BE and the subsequent development of EAC in women compared to men, and this effect may be responsible for the male predominance. However, some observational studies demonstrated that hormone replacement therapy exerts controversial effects in GERD patients. Nevertheless, the estrogen-related endocrine milieu may prevent disease progression toward carcinogenesis in GERD patients. The development of innovative alternatives to conventional acid suppressors may become possible by clarifying the mechanisms of estrogen.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Asanuma,K., Iijima,K., Shimosegawa,T.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC4724611
Editors
Gender differences in health conditions and socio-economic status of adults with congenital heart disease in a developing country 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Cardiol Young
Periodical, Abbrev.
Cardiol.Young
Pub Date Free Form
Volume
23
Issue
2
Start Page
209
Other Pages
18
Notes
ID: 22717060
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
BACKGROUND: Providing appropriate care for adults with congenital heart disease requires the evaluation of their current situation. There is limited research in Iran about these patients, particularly in relation to gender differences in the demographic/socio-economic and lifestyle factors, as well as disease parameters. MATERIALS AND METHODS: The sample consisted of 347 congenital heart disease patients in the age group of 18­64 years, including 181 women, assessed by an analytical cross-sectional study. The patients were recruited from the two major heart hospitals in Tehran. Data were collected using questionnaires. RESULTS: The mean age of the patients was 33.24 years. Women were more often married and more often had offspring than men (p
Descriptors
Links
http://dx.doi.org/10.1017/S1047951112000625
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Eslami,Bahareh, Sundin,Orjan, Macassa,Gloria, Reza Khankeh, Hamid, Soares,Joaquim J.F.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Gender differences in patterns and correlates of khat and tobacco use 2013
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine Tob Res
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Volume
15
Issue
6
Start Page
1130
Other Pages
5
Notes
ID: 23197767
Place of Publication
ISSN/ISBN
Accession Number
Language
en
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
INTRODUCTION: Although research suggests gender differences in patterns of tobacco use, whether gender moderates concurrent use of tobacco and other substances remains unclear. In some parts of Africa and the Middle East, tobacco is often accompanied with khat (Catha edulis), a widely used substance in these regions. The concurrent use of tobacco and khat may represent a public health burden spreading to other countries in Europe and North America. METHOD: A total of 189 participants (69 women) khat users and smokers in Yemen were asked to complete questionnaires that focused on patterns of khat and tobacco use. Chi-square tests, analyses of variance, and correlational analyses were conducted. RESULTS: Reported frequency and intensity of khat and tobacco use were greater among men than in women. Also, reported number of cigarettes smoked during a khat session was higher among men than among women, whereas frequency of waterpipe use during the session was greater among women than among men. Smoking status (daily or occasional) was positively associated with khat use in women only. Age of onset of khat use was inversely related to the number of cigarettes smoked during a khat session and with intensity of khat chewing. The majority of participants reported that they had thought about and have attempted to quit khat and tobacco use. CONCLUSIONS: The results provide evidence for gender differences in patterns of concurrent use of tobacco and khat. Identifying determinants of tobacco and khat use may be useful in reducing the risk of their negative health outcomes.
Descriptors
Links
Book Title
Database
MEDLINE; http://www.globalhealthlibrary.net/
Publisher
Data Source
Authors
Nakajima,Motohiro, al'Absi, Mustafa, Dokam,Anisa, Alsoofi,Mohammed, Khalil,Najat Sayem, Al Habori, Molham
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Gender differences in smoking behavior among adolescents in Saudi Arabia 2007 Faculty of Medicine, King Fahad Medical City, College of Applied Medicine, King Saud University, PO Box 59048 Riyadh 11525, Kingdom of Saudi Arabia. Abdallaali63@hotmail.com
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Saudi medical journal
Periodical, Abbrev.
Saudi Med.J.
Pub Date Free Form
Jul
Volume
28
Issue
7
Start Page
1102
Other Pages
1108
Notes
LR: 20141120; JID: 7909441; ppublish
Place of Publication
Saudi Arabia
ISSN/ISBN
0379-5284; 0379-5284
Accession Number
PMID: 17603720
Language
eng
SubFile
Comparative Study; Journal Article; IM
DOI
20060965' [pii]
Output Language
Unknown(0)
PMID
17603720
Abstract
OBJECTIVE: To describe and assess gender differences in current cigarette smokers' according to certain variables including prevalence, access to tobacco, knowledge and attitude, environmental tobacco smoke, cessation of smoking, tobacco related advertisements, and education on tobacco in school among adolescents in grades 7-12 in Tabuk, Saudi Arabia. METHODS: A random sample of schools in Tabuk city was obtained using a 2-stage cluster, in April 2005. A total of 16 governmental schools were selected. Within the schools, 48 classes were selected, targeting grades was 7 to 12. An anonymous, self-administered questionnaire was used to select 1,505 participants, with 96% response rate. RESULTS: Out of 1,505 students, 22.3% (34% males, 11.1% females) were current cigarette smokers (students who had smoked on one or more days in the 30 days preceding the survey), and 5.8% (11.1% males, 0.7% females) were daily smokers. There were significant gender differences concerning source of cigarettes, usual place of smoke, intensity of smoking, knowledge on addiction of tobacco, exposure to education on tobacco, attitudes, and exposure to tobacco smoke in public places. While no significant gender differences were found with respect to age of initiation, knowledge of health hazards of tobacco, exposure to media, desire to quit, or exposure to tobacco smoke at home. CONCLUSION: For the suppression of the use of tobacco by adolescents in Saudi Arabia differential intervention strategies and policies in males and females are needed, such as reducing youth access to cigarettes-in addition to intensive school and community anti-tobacco programs.
Descriptors
Adolescent, Child, Female, Humans, Male, Psychology, Adolescent, Saudi Arabia, Sex Factors, Smoking, Smoking Cessation
Links
Book Title
Database
Publisher
Data Source
Authors
Abdalla,A. M., Al-Kaabba,A. F., Saeed,A. A., Abdulrahman,B. M., Raat,H.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Gender differences influence overweight smokers' experimentation with electronic nicotine delivery systems 2015 Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States. Electronic address: dstrong@ucsd.edu.; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States.; Department
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Addictive Behaviors
Periodical, Abbrev.
Addict.Behav.
Pub Date Free Form
Oct
Volume
49
Issue
Start Page
20
Other Pages
25
Notes
LR: 20151001; CI: Copyright (c) 2015; GR: T32 HL079891/HL/NHLBI NIH HHS/United States; JID: 7603486; NIHMS696056; OID: NLM: NIHMS696056; OID: NLM: PMC4478105; OTO: NOTNLM; 2014/08/28 [received]; 2015/04/28 [revised]; 2015/05/04 [accepted]; 2015/05/09 [ahe
Place of Publication
England
ISSN/ISBN
1873-6327; 0306-4603
Accession Number
PMID: 26036665
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.addbeh.2015.05.003 [doi]
Output Language
Unknown(0)
PMID
26036665
Abstract
INTRODUCTION: Overweight and obese tobacco users possess increased risk of cancer, diabetes, heart disease and chronic tobacco-related disease. Efforts to prevent tobacco-related health risk in this comorbid population would be informed by better understanding and monitoring of trends in the concurrent use of electronic nicotine delivery systems (ENDS) among smokers in the US marketplace. METHOD: The California Longitudinal Smokers Study (CLSS) established a cohort of current cigarette smokers in 2011 who were surveyed for tobacco use and health behavior at baseline and again in 2012 at follow-up. RESULTS: We observed a large increase in reported experimentation with ENDS. As hypothesized, overweight or obese smokers were more likely to report experimentation with ENDS, an increase that was also observed among women. Experimentation with ENDS was not associated with a reduction in use of cigarettes or a decrease in cigarette dependence in this high risk population of smokers. CONCLUSIONS: Continued surveillance of this vulnerable population is needed to better understand how experimentation with new ENDS products may impact health, facilitate switching to non-combustible tobacco or facilitate persistent cigarette dependence.
Descriptors
Links
Book Title
Database
Publisher
. Published by Elsevier Ltd
Data Source
Authors
Strong,D.R., Myers,M., Linke,S., Leas,E., Hofstetter,R., Edland,S., Al-Delaimy,W.K.
Original/Translated Title
URL
Date of Electronic
20150509
PMCID
PMC4478105
Editors
Generation of resistance to amphotericin B and caspofungin in Candida spp.: experimental study 2009
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of chemotherapy (Florence, Italy)
Periodical, Abbrev.
J.Chemother.
Pub Date Free Form
Aug
Volume
21
Issue
4
Start Page
467
Other Pages
469
Notes
LR: 20131121; JID: 8907348; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); F0XDI6ZL63 (caspofungin); ppublish
Place of Publication
Italy
ISSN/ISBN
1973-9478; 1120-009X
Accession Number
PMID: 19622473
Language
eng
SubFile
Letter; IM
DOI
10.1179/joc.2009.21.4.467 [doi]
Output Language
Unknown(0)
PMID
19622473
Abstract
Descriptors
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Candida/drug effects/growth & development, Dose-Response Relationship, Drug, Drug Resistance, Fungal, Echinocandins/pharmacology, Humans, Microbial Sensitivity Tests
Links
Book Title
Database
Publisher
Data Source
Authors
Soler,L., Pastor,E., Rodriguez,J. C., Ruiz,M., Lopez,P., Cremades,R., Royo,G.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Genetic analysis of strawberry fruit aroma and identification of O-methyltransferase FaOMT as the locus controlling natural variation in mesifurane content 2012 Instituto Andaluz de Investigacion y Formacion Agraria y Pesquera, Centro de Churriana, 29140 Malaga, Spain.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Plant Physiology
Periodical, Abbrev.
Plant Physiol.
Pub Date Free Form
Jun
Volume
159
Issue
2
Start Page
851
Other Pages
870
Notes
LR: 20150225; GENBANK/JQ322651; GENBANK/JQ322652; GENBANK/JQ322653; GENBANK/JQ322654; GENBANK/JQ322655; GENBANK/JQ322656; GENBANK/JQ322657; GENBANK/JQ322658; GENBANK/JQ322659; JID: 0401224; 0 (Flavoring Agents); 0 (Furans); 0 (Volatile Organic Compounds);
Place of Publication
United States
ISSN/ISBN
1532-2548; 0032-0889
Accession Number
PMID: 22474217
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1104/pp.111.188318 [doi]
Output Language
Unknown(0)
PMID
22474217
Abstract
Improvement of strawberry (Fragaria x ananassa) fruit flavor is an important goal in breeding programs. To investigate genetic factors controlling this complex trait, a strawberry mapping population derived from genotype '1392', selected for its superior flavor, and '232' was profiled for volatile compounds over 4 years by headspace solid phase microextraction coupled to gas chromatography and mass spectrometry. More than 300 volatile compounds were detected, of which 87 were identified by comparison of mass spectrum and retention time to those of pure standards. Parental line '1392' displayed higher volatile levels than '232', and these and many other compounds with similar levels in both parents segregated in the progeny. Cluster analysis grouped the volatiles into distinct chemically related families and revealed a complex metabolic network underlying volatile production in strawberry fruit. Quantitative trait loci (QTL) detection was carried out over 3 years based on a double pseudo-testcross strategy. Seventy QTLs covering 48 different volatiles were detected, with several of them being stable over time and mapped as major QTLs. Loci controlling gamma-decalactone and mesifurane content were mapped as qualitative traits. Using a candidate gene approach we have assigned genes that are likely responsible for several of the QTLs. As a proof of concept we show that one homoeolog of the O-methyltransferase gene (FaOMT) is the locus responsible for the natural variation of mesifurane content. Sequence analysis identified 30 bp in the promoter of this FaOMT homoeolog containing putative binding sites for basic/helix-loop-helix, MYB, and BZIP transcription factors. This polymorphism fully cosegregates with both the presence of mesifurane and the high expression of FaOMT during ripening.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Zorrilla-Fontanesi,Y., Rambla,J.L., Cabeza,A., Medina,J.J., Sanchez-Sevilla,J.F., Valpuesta,V., Botella,M.A., Granell,A., Amaya,I.
Original/Translated Title
URL
Date of Electronic
20120403
PMCID
PMC3375946
Editors
Genetic characterisation of extended-spectrum beta-lactamases in Escherichia coli isolated from retail chicken products including CTX-M-9 containing isolates: a food safety risk factor 2012 Centre of Studies of Animal and Veterinary Sciences, Vila Real, Portugal.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
British poultry science
Periodical, Abbrev.
Br.Poult.Sci.
Pub Date Free Form
Volume
53
Issue
6
Start Page
747
Other Pages
755
Notes
JID: 15740290R; 0 (Escherichia coli Proteins); 0 (beta-Lactams); EC 3.5.2.- (CTX-M-9 protein, E coli); EC 3.5.2.6 (beta-Lactamases); ppublish
Place of Publication
England
ISSN/ISBN
1466-1799; 0007-1668
Accession Number
PMID: 23398418
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1080/00071668.2012.740554 [doi]
Output Language
Unknown(0)
PMID
23398418
Abstract
1. Bacterial resistance to beta-lactam antibiotics has risen dramatically in Escherichia coli from food animals. In a previous study, 29 randomly selected chicken products, collected in Portugal, were analysed for the presence of extended-spectrum beta-lactamases (ESBLs)-producing E. coli; and during this study the genetic characterisation of ESBLs genes was investigated. 2. The presence of genes encoding TEM, OXA, SHV, and CTX-M type beta-lactamases was studied by PCR followed by sequencing. Additionally, other mechanisms of antimicrobial resistance, phylogenetic groups and the presence of virulence determinants were evaluated among the isolates. 3. beta-lactamases genes were identified as follows: bla (CTX-M-14) (n = 4), bla (CTX-M-1) (n = 2), bla (CTX-M-9) (n = 4) and bla (TEM-52) (n = 13). Mutations at positions -42, -18, -1, and +58 of ampC promoter region were identified in 4 non-ESBL-producing isolates. The tet(A) or tet(B) genes were identified in all tetracycline-resistant isolates; the aadA gene detected in 8 of 10 streptomycin-resistant isolates; the aac(3)-II gene in all gentamicin-resistant isolates; the cmlA gene in the chloramphenicol-resistant isolate; and sul1 and/or sul2 and/or sul3 genes were found in all trimethoprim-sulfamethoxazole-resistant isolates. The intI1 gene was detected in 8 trimethoprim-sulfamethoxazole-resistant isolates and the intI2 gene in 4 isolates; one gene cassette arrangements were identified among class 1 integrons (dfrA1 + aadA1) and among the class 2 integrons (dfrA1 + sat2 + aadA1). Among cefotaxime-resistant isolates, 16 belonged to A or B1 phylogenetic groups, while 11 isolates were classified into the D or B2 phylogroups. At least one virulence-associated gene (aer, fimA, or papC) was detected in 74.1% of the cefotaxime-resistant isolates. 4. Because ESBLs-producing bacteria are resistant to a broad range of beta-lactams, infections caused by these organisms complicate therapy and limit treatment options.
Descriptors
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Book Title
Database
Publisher
Data Source
Authors
Silva,N., Costa,L., Goncalves,A., Sousa,M., Radhouani,H., Brito,F., Igrejas,G., Poeta,P.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Genetic characterization of extended-spectrum beta-lactamases in Escherichia coli isolates of pigs from a Portuguese intensive swine farm 2010 Center of Genetics and Biotechnology/Institute for Biotechnology and Bioengineering, University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Foodborne pathogens and disease
Periodical, Abbrev.
Foodborne Pathog.Dis.
Pub Date Free Form
Dec
Volume
7
Issue
12
Start Page
1569
Other Pages
1573
Notes
JID: 101120121; 0 (Escherichia coli Proteins); 0 (Genetic Markers); EC 3.5.2.- (beta-lactamase TEM-3); EC 3.5.2.6 (beta-Lactamases); 2010/08/12 [aheadofprint]; ppublish
Place of Publication
United States
ISSN/ISBN
1556-7125; 1535-3141
Accession Number
PMID: 20704503
Language
eng
SubFile
Journal Article; IM
DOI
10.1089/fpd.2010.0598 [doi]
Output Language
Unknown(0)
PMID
20704503
Abstract
There is a great concern by the emergence and the wide dissemination of extended-spectrum beta-lactamases (ESBLs) among animal Escherichia coli isolates. We intended to determinate the carriage level and type of ESBLs in E. coli obtained from fecal samples from pigs raised on an intensive pig farm in Portugal; further to characterize other associated resistance genes and their plasmid content, the phylogenetic groups, and the clonal relationship of ESBL-positive isolates. Sixty-five fecal samples were seeded in Levine media supplemented with cefotaxime for E. coli recovery. Susceptibility to 16 antimicrobial agents was performed by disk diffusion agar. ESBL-phenotypic detection was carried out by double-disk test; and the presence of the genes encoding TEM, OXA, SHV, and CTX-M type beta-lactamases was studied by polymerase chain reaction and sequencing. Other mechanisms of antimicrobial resistance and phylogenetic groups were also determined. Clonal relationship was performed by pulsed-field gel electrophoresis. ESBL-producing E. coli isolates were detected in 16 fecal samples, and one isolate per sample was studied. The CTX-M-1 type ESBL was detected in the 16 isolates. The gene encoding TEM-1 was identified to be associated with eight CTX-M-1-positive isolates. The tet(A) gene was found in 12 of 14 tetracycline-resistant isolates, and the aadA or strA-strB genes were found in the streptomycin-resistant isolates. Fourteen and two ESBL-containing isolates belonged to A and B1 phylogenetic groups, respectively. Clonal relationship of ESBL-containing isolates identified seven unrelated patterns. Swine represent an important reservoir of ESBL-containing E. coli isolates, especially of the CTX-M-1 type.
Descriptors
Animals, Drug Resistance, Bacterial, Electrophoresis, Gel, Pulsed-Field, Escherichia coli/drug effects/enzymology/growth & development/isolation & purification, Escherichia coli Proteins/genetics, Feces/microbiology, Genes, MDR, Genetic Markers, Microbial Sensitivity Tests, Plasmids/genetics, Polymerase Chain Reaction, Portugal, Swine/microbiology, beta-Lactamases/genetics
Links
Book Title
Database
Publisher
Data Source
Authors
Goncalves,A., Torres,C., Silva,N., Carneiro,C., Radhouani,H., Coelho,C., Araujo,C., Rodrigues,J., Vinue,L., Somalo,S., Poeta,P., Igrejas,G.
Original/Translated Title
URL
Date of Electronic
20100812
PMCID
Editors
Genetic risk assessment in hookah smokers. 2000 Yadav, J.S., Department of Zoology, Kurukshetra University, India.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Cytobios
Periodical, Abbrev.
Cytobios
Pub Date Free Form
/
Volume
101
Issue
397
Start Page
101
Other Pages
113
Notes
Place of Publication
ISSN/ISBN
0011-4529
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
The genotoxic effect of hookah smoke was investigated on somatic chromosomes of 35 occupationally nonexposed male hookah smokers. These were compared with an equal number of nonsmokers matched with respect to age, sex, drug intake, if any, and socio-economic status. The mitotic index (MI), chromosomal aberrations (CA), sister chromatid exchanges (SCE) and satellite associations (SA) were analysed. All the parameters showed a significant increase (p < 0.01) in the smokers compared with control individuals, viz MI, 3.88-5.41; CA, 0.94-2.22; SCE, 3.59-5.66; and SA, 5.2-8.65. A distinct time and dose effect relationship was observed. Hookah smoke is thus, both clastogenic and genotoxic for human beings.
Descriptors
adult, aged, article, drug effect, human, human chromosome, India, male, middle aged, mitosis, mutagen testing, plant, risk assessment, smoking, tobacco
Links
Book Title
Database
MEDLINE
Publisher
Data Source
Embase
Authors
Yadav,J. S., Thakur,S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors