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The subject of interest is:
waterpipe, water-pipe, nargile, narghile, arguileh, arguile, shisha, sheesha, chichi, hubble bubble, hubbly bubbly, goza, hookah, bong
| Title Sort descending | Pub Year | Author | SearchLink |
|---|---|---|---|
| Effect of waterpipe tobacco smoke exposure during lactation on learning and memory of offspring rats: Role of oxidative stress | 2019 | Read more... | |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Life Sciences
Periodical, Abbrev.
Life Sci.
Pub Date Free Form
Volume
Issue
Start Page
Other Pages
Notes
Place of Publication
ISSN/ISBN
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
Links
Book Title
Database
Publisher
Elsevier
Data Source
google
Authors
Al-Sawalha, Nour, Alzoubi, Karem, Khabour, Omar, Alyacoub, Weam, Almahmood, Yehya
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Effect of waterpipe tobacco smoking on airway inflammation in murine model of asthma | 2017 | Read more... | |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Inhalation toxicology
Periodical, Abbrev.
Inhal.Toxicol.
Pub Date Free Form
Volume
29
Issue
2
Start Page
46
Other Pages
52
Notes
Place of Publication
ISSN/ISBN
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
Links
Book Title
Database
Publisher
Taylor & Francis
Data Source
google
Authors
Al-Sawalha, Nour A, Migdadi, Ala’a M, Alzoubi, Karem H, Khabour, Omar F, Qinna, Nidal A
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Effect of waterpipe tobacco smoking on airway inflammation in murine model of asthma | 2017 | Read more... | |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Inhalation toxicology
Periodical, Abbrev.
Inhal.Toxicol.
Pub Date Free Form
Volume
29
Issue
2
Start Page
46
Other Pages
52
Notes
Place of Publication
ISSN/ISBN
Accession Number
Language
SubFile
DOI
Output Language
Unknown(0)
PMID
Abstract
Descriptors
Links
Book Title
Database
Publisher
Taylor & Francis
Data Source
google
Authors
Al-Sawalha, Nour A, Migdadi, Ala’a M, Alzoubi, Karem H, Khabour, Omar F, Qinna, Nidal A
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic review and network meta-analysis | 2012 | School of Health and Population Sciences, University of Birmingham, Birmingham, UK. | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Health technology assessment (Winchester, England)
Periodical, Abbrev.
Health Technol.Assess.
Pub Date Free Form
Volume
16
Issue
38
Start Page
1
Other Pages
205, iii-v
Notes
LR: 20150203; GR: 08/60/01/Department of Health/United Kingdom; GR: G0800800/Medical Research Council/United Kingdom; GR: G0802413/Medical Research Council/United Kingdom; GR: HTA/08/60/01/Department of Health/United Kingdom; JID: 9706284; ppublish
Place of Publication
England
ISSN/ISBN
2046-4924; 1366-5278
Accession Number
PMID: 23046909
Language
eng
SubFile
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.3310/hta16380 [doi]
Output Language
Unknown(0)
PMID
23046909
Abstract
BACKGROUND: Smoking is harmful to health. On average, lifelong smokers lose 10 years of life, and about half of all lifelong smokers have their lives shortened by smoking. Stopping smoking reverses or prevents many of these harms. However, cessation services in the NHS achieve variable success rates with smokers who want to quit. Approaches to behaviour change can be supplemented with electronic aids, and this may significantly increase quit rates and prevent a proportion of cases that relapse. OBJECTIVE: The primary research question we sought to answer was: What is the effectiveness and cost-effectiveness of internet, pc and other electronic aids to help people stop smoking? We addressed the following three questions: (1) What is the effectiveness of internet sites, computer programs, mobile telephone text messages and other electronic aids for smoking cessation and/or reducing relapse? (2) What is the cost-effectiveness of incorporating internet sites, computer programs, mobile telephone text messages and other electronic aids into current nhs smoking cessation programmes? and (3) What are the current gaps in research into the effectiveness of internet sites, computer programs, mobile telephone text messages and other electronic aids to help people stop smoking? DATA SOURCES: For the effectiveness review, relevant primary studies were sought from The Cochrane Library [Cochrane Central Register of Controlled Trials (CENTRAL)] 2009, Issue 4, and MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), Health Management Information Consortium (HMIC) (Ovid) and Cumulative Index to Nursing and Allied Health Literature (CINAHL) (EBSCOhost) from 1980 to December 2009. In addition, NHS Economic Evaluation Database (NHS EED) and Database of Abstracts of Reviews of Effects (DARE) were searched for information on cost-effectiveness and modelling for the same period. Reference lists of included studies and of relevant systematic reviews were examined to identify further potentially relevant studies. Research registries of ongoing studies including National Institute for Health Research (NIHR) Clinical Research Network Portfolio Database, Current Controlled Trials and ClinicalTrials.gov were also searched, and further information was sought from contacts with experts. REVIEW METHODS: Randomised controlled trials (RCTs) and quasi-RCTs evaluating smoking cessation programmes that utilise computer, internet, mobile telephone or other electronic aids in adult smokers were included in the effectiveness review. Relevant studies of other design were included in the cost-effectiveness review and supplementary review. Pair-wise meta-analyses using both random- and fixed-effects models were carried out. Bayesian mixed-treatment comparisons (MTCs) were also performed. A de novo decision-analytical model was constructed for estimating the cost-effectiveness of interventions. Expected value of perfect information (EVPI) was calculated. Narrative synthesis of key themes and issues that may influence the acceptability and usability of electronic aids was provided in the supplementary review. RESULTS: This effectiveness review included 60 RCTs/quasi-RCTs reported in 77 publications. Pooled estimate for prolonged abstinence [relative risk (RR) = 1.32, 95% confidence interval (CI) 1.21 to 1.45] and point prevalence abstinence (RR = 1.14, 95% CI 1.07 to 1.22) suggested that computer and other electronic aids increase the likelihood of cessation compared with no intervention or generic self-help materials. There was no significant difference in effect sizes between aid to cessation studies (which provide support to smokers who are ready to quit) and cessation induction studies (which attempt to encourage a cessation attempt in smokers who are not yet ready to quit). Results from MTC also showed small but significant intervention effect (time to relapse, mean hazard ratio 0.87, 95% credible interval 0.83 to 0.92). Cost-threshold analyses indicated some form of elect
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Chen,Y.F., Madan,J., Welton,N., Yahaya,I., Aveyard,P., Bauld,L., Wang,D., Fry-Smith,A., Munafo,M.R.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
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| Effectiveness of a proactive mail-based alcohol Internet intervention for university students: dismantling the assessment and feedback components in a randomized controlled trial | 2012 | Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden. preben.bendtsen@liu.se | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
31-Oct
Volume
14
Issue
5
Start Page
e142
Other Pages
Notes
LR: 20150222; ISRCTN/ISRCTN24735383; GR: WT086516MA/Wellcome Trust/United Kingdom; JID: 100959882; OID: NLM: PMC3510746; 2012/01/20 [received]; 2012/07/11 [accepted]; 2012/05/29 [revised]; epublish
Place of Publication
Canada
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 23113955
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.2062 [doi]
Output Language
Unknown(0)
PMID
23113955
Abstract
BACKGROUND: University students in Sweden routinely receive proactive mail-based alcohol Internet interventions sent from student health services. This intervention provides personalized normative feedback on alcohol consumption with suggestions on how to decrease drinking. Earlier feasibility trials by our group and others have examined effectiveness in simple parallel-groups designs. OBJECTIVE: To evaluate the effectiveness of electronic screening and brief intervention, using a randomized controlled trial design that takes account of baseline assessment reactivity (and other possible effects of the research process) due to the similarity between the intervention and assessment content. The design of the study allowed for exploration of the magnitude of the assessment effects per se. METHODS: This trial used a dismantling design and randomly assigned 5227 students to 3 groups: (1) routine practice assessment and feedback, (2) assessment-only without feedback, and (3) neither assessment nor feedback. At baseline all participants were blinded to study participation, with no contact being made with group 3. We approached students 2 months later to participate in a cross-sectional alcohol survey. All interventions were fully automated and did not have any human involvement. All data used in the analysis were based on self-assessment using questionnaires. The participants were unaware that they were participating in a trial and thus were also blinded to which group they were randomly assigned. RESULTS: Overall, 44.69% (n = 2336) of those targeted for study completed follow-up. Attrition was similar in groups 1 (697/1742, 40.01%) and 2 (737/1742, 42.31% retained) and lower in group 3 (902/1743, 51.75% retained). Intention-to-treat analyses among all participants regardless of their baseline drinking status revealed no differences between groups in all alcohol parameters at the 2-month follow-up. Per-protocol analyses of groups 1 and 2 among those who accepted the email intervention (36.2% of the students who were offered the intervention in group 1 and 37.3% of the students in group2 ) and who were risky drinkers at baseline (60.7% follow-up rate in group 1 and 63.5% in group 2) suggested possible small beneficial effects on weekly consumption attributable to feedback. CONCLUSIONS: This approach to outcome evaluation is highly conservative, and small benefits may follow the actual uptake of feedback intervention in students who are risky drinkers, the precise target group. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number (ISRCTN): 24735383; http://www.controlled-trials.com/ISRCTN24735383 (Archived by WebCite at http://www.webcitation.org/6Awq7gjXG).
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Bendtsen,P., McCambridge,J., Bendtsen,M., Karlsson,N., Nilsen,P.
Original/Translated Title
URL
Date of Electronic
20121031
PMCID
PMC3510746
Editors
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| Effectiveness of a rural sanitation programme on diarrhoea, soil-transmitted helminth infection, and child malnutrition in Odisha, India: a cluster-randomised trial | 2014 | Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: tclasen@emory.edu.; Faculty | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Lancet.Global health
Periodical, Abbrev.
Lancet Glob.Health.
Pub Date Free Form
Nov
Volume
2
Issue
11
Start Page
e645
Other Pages
53
Notes
CI: Copyright (c) 2014; ClinicalTrials.gov/NCT01214785; JID: 101613665; 0 (Soil); CIN: Lancet Glob Health. 2015 Jan;3(1):e17. PMID: 25539961; CIN: Lancet Glob Health. 2015 Jan;3(1):e16. PMID: 25539960; CIN: Lancet Glob Health. 2014 Nov;2(11):e619-20. PMID
Place of Publication
England
ISSN/ISBN
2214-109X; 2214-109X
Accession Number
PMID: 25442689
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/S2214-109X(14)70307-9 [doi]
Output Language
Unknown(0)
PMID
25442689
Abstract
BACKGROUND: A third of the 2.5 billion people worldwide without access to improved sanitation live in India, as do two-thirds of the 1.1 billion practising open defecation and a quarter of the 1.5 million who die annually from diarrhoeal diseases. We aimed to assess the effectiveness of a rural sanitation intervention, within the context of the Government of India's Total Sanitation Campaign, to prevent diarrhoea, soil-transmitted helminth infection, and child malnutrition. METHODS: We did a cluster-randomised controlled trial between May 20, 2010, and Dec 22, 2013, in 100 rural villages in Odisha, India. Households within villages were eligible if they had a child younger than 4 years or a pregnant woman. Villages were randomly assigned (1:1), with a computer-generated sequence, to undergo latrine promotion and construction or to receive no intervention (control). Randomisation was stratified by administrative block to ensure an equal number of intervention and control villages in each block. Masking of participants was not possible because of the nature of the intervention. However, households were not told explicitly that the purpose of enrolment was to study the effect of a trial intervention, and the surveillance team was different from the intervention team. The primary endpoint was 7-day prevalence of reported diarrhoea in children younger than 5 years. We did intention-to-treat and per-protocol analyses. This trial is registered with ClinicalTrials.gov, number NCT01214785. FINDINGS: We randomly assigned 50 villages to the intervention group and 50 villages to the control group. There were 4586 households (24,969 individuals) in intervention villages and 4894 households (25,982 individuals) in control villages. The intervention increased mean village-level latrine coverage from 9% of households to 63%, compared with an increase from 8% to 12% in control villages. Health surveillance data were obtained from 1437 households with children younger than 5 years in the intervention group (1919 children younger than 5 years), and from 1465 households (1916 children younger than 5 years) in the control group. 7-day prevalence of reported diarrhoea in children younger than 5 years was 8.8% in the intervention group and 9.1% in the control group (period prevalence ratio 0.97, 95% CI 0.83-1.12). 162 participants died in the intervention group (11 children younger than 5 years) and 151 died in the control group (13 children younger than 5 years). INTERPRETATION: Increased latrine coverage is generally believed to be effective for reducing exposure to faecal pathogens and preventing disease; however, our results show that this outcome cannot be assumed. As efforts to improve sanitation are being undertaken worldwide, approaches should not only meet international coverage targets, but should also be implemented in a way that achieves uptake, reduces exposure, and delivers genuine health gains. FUNDING: Bill & Melinda Gates Foundation, International Initiative for Impact Evaluation (3ie), and Department for International Development-backed SHARE Research Consortium at the London School of Hygiene & Tropical Medicine.
Descriptors
Links
Book Title
Database
Publisher
Clasen et al. Open Access article distributed under the terms of CC BY-NC-ND. Published by .
Data Source
Authors
Clasen,T., Boisson,S., Routray,P., Torondel,B., Bell,M., Cumming,O., Ensink,J., Freeman,M., Jenkins,M., Odagiri,M., Ray,S., Sinha,A., Suar,M., Schmidt,W.P.
Original/Translated Title
URL
Date of Electronic
20141009
PMCID
Editors
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| Effectiveness of a stepped primary care smoking cessation intervention: cluster randomized clinical trial (ISTAPS study) | 2011 | Subdireccio General de Promocio de la Salut, Direccio General de Salut Publica, Departament de Salut, Barcelona, Spain. carmen.cabezas@gencat.cat | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Addiction (Abingdon, England)
Periodical, Abbrev.
Addiction
Pub Date Free Form
Sep
Volume
106
Issue
9
Start Page
1696
Other Pages
1706
Notes
LR: 20151119; CI: (c) 2011 The Authors, Addiction (c) 2011; ClinicalTrials.gov/NCT00125905; JID: 9304118; 0 (Antidepressive Agents, Second-Generation); 0 (Chewing Gum); 0 (Nicotinic Agonists); 01ZG3TPX31 (Bupropion); 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Car
Place of Publication
England
ISSN/ISBN
1360-0443; 0965-2140
Accession Number
PMID: 21561497
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.1111/j.1360-0443.2011.03491.x [doi]
Output Language
Unknown(0)
PMID
21561497
Abstract
AIM: To evaluate the effectiveness in primary care of a stepped smoking cessation intervention based on the transtheoretical model of change. DESIGN: Cluster randomized trial; unit of randomization: basic care unit (family physician and nurse who care for the same group of patients); and intention-to-treat analysis. SETTING: All interested basic care units (n = 176) that worked in 82 primary care centres belonging to the Spanish Preventive Services and Health Promotion Research Network in 13 regions of Spain. PARTICIPANTS: A total of 2,827 smokers (aged 14-85 years) who consulted a primary care centre for any reason, provided written informed consent and had valid interviews. MEASUREMENTS: The outcome variable was the 1-year continuous abstinence rate at the 2-year follow-up. The main variable was the study group (intervention/control). Intervention involved 6-month implementation of recommendations from a Clinical Practice Guideline which included brief motivational interviews for smokers at the precontemplation-contemplation stage, brief intervention for smokers in preparation-action who do not want help, intensive intervention with pharmacotherapy for smokers in preparation-action who want help and reinforcing intervention in the maintenance stage. Control group involved usual care. Among others, characteristics of tobacco use and motivation to quit variables were also collected. FINDINGS: The 1-year continuous abstinence rate at the 2-year follow-up was 8.1% in the intervention group and 5.8% in the control group (P = 0.014). In the multivariate logistic regression, the odds of quitting of the intervention versus control group was 1.50 (95% confidence interval = 1.05-2.14). CONCLUSIONS: A stepped smoking cessation intervention based on the transtheoretical model significantly increased smoking abstinence at a 2-year follow-up among smokers visiting primary care centres.
Descriptors
Links
Book Title
Database
Publisher
Society for the Study of Addiction
Data Source
Authors
Cabezas,C., Advani,M., Puente,D., Rodriguez-Blanco,T., Martin,C., ISTAPS Study Group
Original/Translated Title
URL
Date of Electronic
20110722
PMCID
Editors
|
|||
| Effectiveness of a web-based brief alcohol intervention and added value of normative feedback in reducing underage drinking: a randomized controlled trial | 2010 | Department of Developmental Psychopathology, Behavioural Science Institute, Radboud University, Nijmegen, Netherlands. r.spijkerman@pwo.ru.nl | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
19-Dec
Volume
12
Issue
5
Start Page
e65
Other Pages
Notes
LR: 20150205; JID: 100959882; OID: NLM: PMC3057308; 2010/01/08 [received]; 2010/11/04 [accepted]; 2010/11/04 [revised]; epublish
Place of Publication
United States
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 21169172
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.1465 [doi]
Output Language
Unknown(0)
PMID
21169172
Abstract
BACKGROUND: Current insights indicate that Web-based delivery may enhance the implementation of brief alcohol interventions. Previous research showed that electronically delivered brief alcohol interventions decreased alcohol use in college students and adult problem drinkers. To date, no study has investigated the effectiveness of Web-based brief alcohol interventions in reducing alcohol use in younger populations. OBJECTIVE: The present study tested 2 main hypotheses, that is, whether an online multicomponent brief alcohol intervention was effective in reducing alcohol use among 15- to 20-year-old binge drinkers and whether inclusion of normative feedback would increase the effectiveness of this intervention. In additional analyses, we examined possible moderation effects of participant's sex, which we had not a priori hypothesized. METHOD: A total of 575 online panel members (aged 15 to 20 years) who were screened as binge drinkers were randomly assigned to (1) a Web-based brief alcohol intervention without normative feedback, (2) a Web-based brief alcohol intervention with normative feedback, or (3) a control group (no intervention). Alcohol use and moderate drinking were assessed at baseline, 1 month, and 3 months after the intervention. Separate analyses were conducted for participants in the original sample (n = 575) and those who completed both posttests (n = 278). Missing values in the original sample were imputed by using the multiple imputation procedure of PASW Statistics 18. RESULTS: Main effects of the intervention were found only in the multiple imputed dataset for the original sample suggesting that the intervention without normative feedback reduced weekly drinking in the total group both 1 and 3 months after the intervention (n =575, at the 1-month follow-up, beta = -.24, P = .05; at the 3-month follow-up, beta = -.25, P = .04). Furthermore, the intervention with normative feedback reduced weekly drinking only at 1 month after the intervention (n=575, beta = -.24, P = .008). There was also a marginally significant trend of the intervention without normative feedback on responsible drinking at the 3-month follow-up (n =575, beta = .40, P =.07) implying a small increase in moderate drinking at the 3-month follow-up. Additional analyses on both datasets testing our post hoc hypothesis about a possible differential intervention effect for males and females revealed that this was the case for the impact of the intervention without normative feedback on weekly drinking and moderate drinking at the 1-month follow-up (weekly drinking for n = 278, beta = -.80, P = .01, and for n = 575, beta = -.69, P = .009; moderate drinking for n = 278, odds ratio [OR] = 3.76, confidence interval [CI] 1.05 - 13.49, P = .04, and for n = 575, OR = 3.00, CI = 0.89 - 10.12, P = .08) and at the 3-month follow-up (weekly drinking for n = 278, beta = -.58, P = .05, and for n = 575, beta = -.75, P = .004; moderate drinking for n = 278, OR = 4.34, CI = 1.18 - 15.95, P = .04, and for n = 575, OR = 3.65, CI = 1.44 - 9.25, P = .006). Furthermore, both datasets showed an interaction effect between the intervention with normative feedback and participant's sex on weekly alcohol use at the 1-month follow-up (for n = 278, beta = -.74, P =.02, and for n = 575, beta = -.64, P =.01) and for moderate drinking at the 3-month follow-up (for n = 278, OR = 3.10, CI = 0.81 - 11.85, P = .07, and for n = 575, OR = 3.00, CI = 1.23 - 7.27, P = .01). Post hoc probing indicated that males who received the intervention showed less weekly drinking and were more likely to drink moderately at 1 month and at 3 months following the intervention. For females, the interventions yielded no effects: the intervention without normative feedback even showed a small unfavorable effect at the 1-month follow-up. CONCLUSION: The present study demonstrated that exposure to a Web-based brief alcohol intervention generated a decrease in weekly drinking among 15- to 20-year-o
Descriptors
Adolescent, Adolescent Behavior/psychology, Alcohol Drinking/epidemiology/therapy, Alcohol-Related Disorders/prevention & control/therapy, Computer-Assisted Instruction/statistics & numerical data, Counseling, Female, Health Behavior, Health Education/methods/statistics & numerical data, Humans, Internet/utilization, Male, Patient Compliance/statistics & numerical data, Program Evaluation, Self-Help Groups, Students/psychology/statistics & numerical data, Therapy, Computer-Assisted/methods/statistics & numerical data, Treatment Outcome
Links
Book Title
Database
Publisher
Data Source
Authors
Spijkerman,R., Roek,M. A., Vermulst,A., Lemmers,L., Huiberts,A., Engels,R. C.
Original/Translated Title
URL
Date of Electronic
20101219
PMCID
PMC3057308
Editors
|
|||
| Effectiveness of a web-based cognitive-behavioral tool to improve mental well-being in the general population: randomized controlled trial | 2012 | Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom. john.powell@phc.ox.ac.uk | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
31-Dec
Volume
15
Issue
1
Start Page
e2
Other Pages
Notes
LR: 20151119; ISRCTN/ISRCTN48134476; GR: PDA/02/06/096/Department of Health/United Kingdom; JID: 100959882; OID: NLM: PMC3636304; 2012/06/26 [received]; 2012/10/04 [accepted]; 2012/10/02 [revised]; epublish
Place of Publication
Canada
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 23302475
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; IM
DOI
10.2196/jmir.2240 [doi]
Output Language
Unknown(0)
PMID
23302475
Abstract
BACKGROUND: Interventions to promote mental well-being can bring benefits to the individual and to society. The Internet can facilitate the large-scale and low-cost delivery of individually targeted health promoting interventions. OBJECTIVE: To evaluate the effectiveness of a self-directed Internet-delivered cognitive-behavioral skills training tool in improving mental well-being in a population sample. METHODS: This was a randomized trial with a waiting-list control. Using advertisements on a national health portal and through its mailing list, we recruited 3070 participants aged 18 or over, resident in England, and willing to give their email address and access a fully automated Web-based intervention. The intervention (MoodGYM) consisted of 5 interactive modules that teach cognitive-behavioral principles. Participants in the intervention arm received weekly email reminders to access the intervention. The control group received access to the intervention after the trial was completed and received no specific intervention or email reminders. Outcomes were assessed by using self-completion questionnaires. The primary outcome was mental well-being measured with the Warwick-Edinburgh Mental Well-being Scale (WEMWBS). Secondary outcomes were Center for Epidemiologic Studies Depression scale (CES-D) depression scores, Generalized Anxiety Disorder 7-item scale (GAD-7) anxiety scores, EuroQol Group 5-Dimension Self-Report Questionnaire (EQ-5D) quality of life scores, physical activity, and health service use. All outcomes were measured at baseline, and at 6- and 12-week follow-ups. RESULTS: A total of 1529 (49.80%) participants completed final follow-up at 12 weeks. Retention was 73.11% (1123/1536) in the control arm and 26.47% (406/1534) in the intervention arm. No relationship between baseline measures and withdrawal could be established. The analysis of WEMWBS mental well-being scores using a linear mixed model for repeated measures showed no difference between intervention and control group at baseline (difference -0.124 points, 95% CI -0.814 to 0.566), and significant improvements for the intervention group at 6 weeks (2.542 points, 95% CI 1.693-3.390) and at 12 weeks (2.876 points, 95% CI 1.933-3.819). The model showed a highly significant (P<.001 intervention="" by="" time="" interaction="" effect.="" there="" were="" also="" significant="" improvements="" in="" self-rated="" scores="" of="" depression="" and="" anxiety.="" given="" the="" high="" level="" attrition="" a="" sensitivity="" analysis="" with="" imputed="" missing="" values="" was="" undertaken="" that="" showed="" positive="" effect="" intervention.="" conclusions:="" participants="" allocated="" to="" arm="" had="" an="" average="" increase="" approximately="" points="" on="" wemwbs="" scale="" compared="" no="" for="" control="" group.="" three="" this="" is="" one-third="" standard="" deviation.="" low-cost="" automated="" designed="" shift="" population="" distribution="" mental="" well-being="" small="" difference="" per="" individual="" could="" yield="" major="" benefit="" terms.="" common="" other="" web-based="" interventions="" rates="" attrition.="" further="" work="" needed="" improve="" acceptability="" evaluate="" against="" placebo="" disaggregate="" from="" trial="" registration:="" international="" randomised="" controlled="" number="" register="" isrctn="" http:="" webcite="" at="">
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Powell,J., Hamborg,T., Stallard,N., Burls,A., McSorley,J., Bennett,K., Griffiths,K.M., Christensen,H.
Original/Translated Title
URL
Date of Electronic
20121231
PMCID
PMC3636304
Editors
|
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| Effectiveness of a web-based self-help intervention for symptoms of depression, anxiety, and stress: randomized controlled trial | 2008 | FPP, Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. a.van.straten@psy.vu.nl | Read more... |
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Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical Internet research
Periodical, Abbrev.
J.Med.Internet Res.
Pub Date Free Form
25-Mar
Volume
10
Issue
1
Start Page
e7
Other Pages
Notes
LR: 20140904; ISRCTN/ISRCTN14881571; JID: 100959882; OID: NLM: PMC2483843; 2007/07/10 [received]; 2008/01/04 [accepted]; 2007/12/20 [revised]; epublish
Place of Publication
United States
ISSN/ISBN
1438-8871; 1438-8871
Accession Number
PMID: 18364344
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; IM
DOI
10.2196/jmir.954 [doi]
Output Language
Unknown(0)
PMID
18364344
Abstract
BACKGROUND: Self-help therapies are often effective in reducing mental health problems. We developed a new Web-based self-help intervention based on problem-solving therapy, which may be used for people with different types of comorbid problems: depression, anxiety, and work-related stress. OBJECTIVE: The aim was to study whether a Web-based self-help intervention is effective in reducing depression, anxiety, and work-related stress (burnout). METHODS: A total of 213 participants were recruited through mass media and randomized to the intervention (n = 107) or a waiting list control group (n = 106). The Web-based course took 4 weeks. Every week an automated email was sent to the participants to explain the contents and exercises for the coming week. In addition, participants were supported by trained psychology students who offered feedback by email on the completed exercises. The core element of the intervention is a procedure in which the participants learn to approach solvable problems in a structured way. At pre-test and post-test, we measured the following primary outcomes: depression (CES-D and MDI), anxiety (SCL-A and HADS), and work-related stress (MBI). Quality of life (EQ-5D) was measured as a secondary outcome. Intention-to-treat analyses were performed. RESULTS: Of the 213 participants, 177 (83.1%) completed the baseline and follow-up questionnaires; missing data were statistically imputed. Of all 107 participants in the intervention group, 9% (n = 10) dropped out before the course started and 55% (n = 59) completed the whole course. Among all participants, the intervention was effective in reducing symptoms of depression (CES-D: Cohen's d = 0.50, 95% confidence interval (CI) 0.22-0.79; MDI: d = 0.33, 95% CI 0.03-0.63) and anxiety (SCL-A: d = 0.42, 95% CI 0.14-0.70; HADS: d = 0.33, 95% CI 0.04-0.61) as well as in enhancing quality of life (d = 0.31, 95% CI 0.03-0.60). Moreover, a higher percentage of patients in the intervention group experienced a significant improvement in symptoms (CES-D: odds ratio [OR] = 3.5, 95% CI 1.9-6.7; MDI: OR = 3.7, 95% CI 1.4-10.0; SCL-A: OR = 2.1, 95% CI 1.0-4.6; HADS: OR = 3.1, 95% CI 1.6-6.0). Patients in the intervention group also recovered more often (MDI: OR = 2.2; SCL-A: OR = 2.0; HADS < 8), although these results were not statistically significant. The course was less effective for work-related stress, but participants in the intervention group recovered more often from burnout than those in the control group (OR = 4.0, 95% CI 1.2-13.5). CONCLUSIONS: We demonstrated statistically and clinically significant effects on symptoms of depression and anxiety. These effects were even more pronounced among participants with more severe baseline problems and for participants who fully completed the course. The effects on work-related stress and quality of life were less clear. To our knowledge, this is the first trial of a Web-based, problem-solving intervention for people with different types of (comorbid) emotional problems. The results are promising, especially for symptoms of depression and anxiety. Further research is needed to enhance the effectiveness for work-related stress. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number (ISRCTN) 14881571.
Descriptors
Adult, Anxiety/epidemiology/prevention & control, Burnout, Professional/epidemiology/prevention & control, Comorbidity, Confidence Intervals, Depression/epidemiology/prevention & control, Female, Health Knowledge, Attitudes, Practice, Humans, Internet/utilization, Male, Middle Aged, Netherlands, Odds Ratio, Patient Education as Topic/methods/statistics & numerical data, Patient Participation/methods, Professional-Patient Relations, Program Evaluation, Referral and Consultation/statistics & numerical data, Self-Help Groups/statistics & numerical data, Social Support, Therapy, Computer-Assisted/statistics & numerical data
Links
Book Title
Database
Publisher
Data Source
Authors
van Straten,A., Cuijpers,P., Smits,N.
Original/Translated Title
URL
Date of Electronic
20080325
PMCID
PMC2483843
Editors
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